91 results match your criteria Brachioradial Pruritus


The use of dupilumab for the treatment of recalcitrant brachioradial pruritus.

JAAD Case Rep 2021 Apr 17;10:69-71. Epub 2021 Feb 17.

Department of Dermatology, University of California, San Francisco, California.

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Brachioradial pruritus in a patient with metastatic breast cancer to her cervical spine.

JAAD Case Rep 2020 Jul 5;6(7):619-621. Epub 2020 May 5.

Department of Dermatology, University of California, Irvine, California.

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[Clinical shortcuts in the differential diagnosis of pruritus].

Hautarzt 2020 Jul;71(7):493-499

Kompetenzzentrum Chronischer Pruritus (KCP), Klinik für Hautkrankheiten, Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland.

Chronic pruritus is a common and burdensome symptom in medicine. The care of patients with chronic pruritus is very complex not only because of the high prevalence, but also because of the multifactorial character of itch and the lack of approved therapies. In addition to the main patient need to alleviate the pruritus, patients wish to find the cause of chronic pruritus. Read More

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Disabling Pruritus in a Patient With Cervical Stenosis.

J Am Acad Orthop Surg Glob Res Rev 2020 03 9;4(3). Epub 2020 Mar 9.

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY.

Brachioradial pruritus is a rare condition characterized by chronic localized itching of the dorsolateral upper extremities. Although the exact pathophysiology is still unknown, cervical nerve compression is thought to be a cause. We present the case of a 56-year-old man with a 6-year history of disabling chronic bilateral upper extremity pruritus and pain as well as concurrent neck pain. Read More

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Brachioradial pruritus in a 52-year-old woman: A case report.

Case Rep Womens Health 2019 Oct 31;24:e00157. Epub 2019 Oct 31.

Beth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Boston, MA, United States.

Brachioradial pruritus is a specific subtype of neuropathic pruritus that commonly presents in women. This condition is a type of neurological itch that mostly involves the dorsal forearm. It is more common in fair-skinned females, is exacerbated by exposure to bright sunlight or ultraviolet radiation (UVR), and is associated with degenerative changes in the cervical spine. Read More

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October 2019

Treatment Refractory Brachioradial Pruritus Treated with Topical Amitriptyline and Ketamine.

Cureus 2019 Jul 10;11(7):e5117. Epub 2019 Jul 10.

Family Medicine, Largo Medical Center, Largo, USA.

Brachioradial pruritus is an uncommon chronic neurocutaneous condition that often presents as extreme itching, burning or tingling on the dorsolateral aspect of the arm. The lack of primary skin lesions in brachioradial pruritus in addition to its poorly established pathophysiology can often lead to both diagnostic and therapeutic challenges for many physicians. Here, we present a case of brachioradial pruritus and the unique combination of topical amitriptyline and ketamine as an effective therapy, including a brief review of the literature on similar such cases. Read More

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Peripheral Sensitization and Loss of Descending Inhibition Is a Hallmark of Chronic Pruritus.

J Invest Dermatol 2020 01 2;140(1):203-211.e4. Epub 2019 Jul 2.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, North Rhine-Westphalia, Germany. Electronic address:

Neurophysiological mechanisms leading to chronicity of pruritus are not yet fully understood and it is not known whether these mechanisms diverge between different underlying diseases of chronic pruritus (CP). This study aimed to detect such mechanisms in CP of various origins. A total of 120 patients with CP of inflammatory origin (atopic dermatitis), neuropathic origin (brachioradial pruritus), and chronic prurigo of nodular type, the latter as a model for chronic scratching, as well as 40 matched healthy controls participated in this study. Read More

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January 2020

Concurrent notalgia paresthetica and brachioradial pruritus associated with cervical degenerative disc disease.

Cutis 2018 Sep;102(3):185;186;189;190

Department of Orthopedic Surgery, St. Jude Heritage Medical Group, Fullerton, California, USA.

Notalgia paresthetica (NP) is a common, often refractory sensory neuropathic syndrome with the hallmark symptoms of localized pruritus and dysesthesia of the unilateral infrascapular region. Brachioradial pruritus (BRP) is similarly classified as a localized pruritus syndrome but of the upper extremities, typically one or both forearms. Notalgia paresthetica and BRP are both generally chronic, nonlethal, incurable conditions with intermittent remissions and exacerbation. Read More

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September 2018

Brachioradial pruritus treated with computed tomography-guided cervical nerve root block: A case series.

JAAD Case Rep 2018 Aug 25;4(7):640-644. Epub 2018 Jul 25.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.

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Application of an 8% capsaicin patch normalizes epidermal TRPV1 expression but not the decreased intraepidermal nerve fibre density in patients with brachioradial pruritus.

J Eur Acad Dermatol Venereol 2018 Sep 9;32(9):1535-1541. Epub 2018 Mar 9.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.

Background: Topical capsaicin shows efficacy in the treatment of brachioradial pruritus (BRP); however, its mechanisms of action remain unclear.

Objective: The effect of capsaicin on the epidermis (i.e. Read More

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September 2018

Aprepitant for the Treatment of Chronic Refractory Pruritus.

Biomed Res Int 2017 19;2017:4790810. Epub 2017 Sep 19.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Chronic pruritus is a difficult condition to treat and is associated with several comorbidities, including insomnia, depression, and decreased quality of life. Treatment for chronic itch includes corticosteroids, antihistamines, and systemic therapies such as naltrexone, gabapentin, UV light therapy, and immunomodulatory treatments, including azathioprine, methotrexate, and cellcept. However, some patients still remain refractory to conventional therapy. Read More

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Brachioradial Pruritus and Notalgia Paraesthetica: A Comparative Observational Study of Clinical Presentation and Morphological Pathologies.

Acta Derm Venereol 2018 Jan;98(1):82-88

Center for Chronic Pruritus, Department of Dermatology, University Hospital Münster, Von- Esmarch-Str. 58, DE-48149 Münster, Germany.

Brachioradial pruritus (BRP) and notalgia paraesthetica (NP) represent 2 of the most common neuropathic itch syndromes. A total of 58 consecutive patients presenting at the Center for Chronic Pruritus, University Hospital Münster, were analysed with regard to clinical presentation, anatomical and morphological pathologies, impairment in quality of life, and response to treatment with topical capsaicin. Patients with BRP reported stinging and burning more often than those with NP. Read More

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January 2018

Impact of drug therapy on brachioradial pruritus.

An Bras Dermatol 2017 Mar-Apr;92(2):281-282

Department of Dermatology, Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.

Few studies have described therapeutic options in brachioradial pruritus. We describe a cross-sectional study of brachioradial pruritus patients treated in an outpatient unit. We reviewed medical records and interviewed brachioradial pruritus patients without indication for decompressive surgery, in order to access the perceptions of intensity of pruritus prior to treatment and response to therapy. Read More

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October 2017

Pregabalin treatment of three cases with brachioradial pruritus.

Dermatol Ther 2017 Mar 6;30(2). Epub 2017 Feb 6.

Department of Physical Medicine and Rehabilitation, Dr. Siyami Ersek Thorax and Cardiaovascular Surgery Training and Research Hospital, İstanbul, Turkey.

Brachioradial pruritus (BRP) is a rare type of chronic pruritus that usually localized at the dorsolateral part of the forearms. Itching, burning, or pain are common symptoms at the involved areas. The etiological factors are still unknown but sun exposure and/or cervical spine lesions seem to be trigerring or precipiting factors. Read More

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Brachioradial pruritus in a 47-year-old woman treated with pregabalin.

G Ital Dermatol Venereol 2016 Dec;151(6):727-728

Section of Dermatology, Department of Biomedical Science and Human Oncology, Policlinico di Bari, Bari, Italy.

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December 2016

Clinical, epidemiological and therapeutic profile of patients with brachioradial pruritus in a reference service in dermatology.

An Bras Dermatol 2016 Jul-Aug;91(4):549-51

Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.

This is a cross-sectional study, conducted from May to November/2014, in a dermatology reference unit, through review of medical records and interviews. In a sample of 49 patients with brachioradial pruritus, we observed higher prevalence of Caucasian (81.6%) and women (73. Read More

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Brachioradial Pruritus as a Harbinger of Syrinx in Chronic Spinal Cord Injury: A Case Report.

PM R 2017 Mar 18;9(3):311-313. Epub 2016 Aug 18.

McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX(†).

This case describes a 56-year-old man with known thoracic spinal cord injury undergoing evaluation for a pruritic rash on the dorsolateral aspect of his forearms with no upper extremity neuromuscular symptoms. Common diagnoses were considered and treated with little success. The diagnosis of brachioradial pruritus (BRP) was made, and evaluation for possible causes revealed a large cervicothoracic syrinx. Read More

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Cost-effectiveness of an 8% Capsaicin Patch in the Treatment of Brachioradial Pruritus and Notalgia Paraesthetica, Two Forms of Neuropathic Pruritus.

Acta Derm Venereol 2017 01;97(1):71-76

Department of Dermatology and Venereology , University Hospital Münster,, DE-48149 Münster, Germany.

In brachioradial pruritus and notalgia paraesthetica, the 8% capsaicin patch is a novel and effective, but cost-intense, therapy. Routine data for 44 patients were collected 6 months retrospectively and prospectively to first patch application. The cost to health insurance and the patient, and patient-reported outcomes were analysed (visual analogue scale, numerical rating scale, verbal rating scale for pruritus symptoms, Dermatological Life Quality Index, and Patient Benefit Index). Read More

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January 2017

Cutaneous manifestations in neuro-oncology: clinically relevant tumor and treatment associated dermatologic findings.

Semin Oncol 2016 06 23;43(3):401-7. Epub 2016 Feb 23.

Department of Neurology, Wake Forest School of Medicine, Winston Salem, NC; Department of Neurology and Oncology, Johns Hopkins School of Medicine, Baltimore, MD.

Skin findings are a rare but important aspect of the evaluation and management of patients with tumors of the nervous system. Skin findings have the highest prevalence in genetic tumor syndromes termed neuro-genodermatoses, which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and tuberous sclerosis. Skin changes are observed in patients with non-syndromic nervous system malignancy, often as a result of pharmacotherapy. Read More

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Neurocutaneous disease: Neurocutaneous dysesthesias.

J Am Acad Dermatol 2016 Feb;74(2):215-28; quiz 229-30

Department of Dermatology, University of Missouri, Columbia, Missouri. Electronic address:

Dysesthesia is a generic term for a cutaneous symptom--such as pruritus, burning, tingling, stinging, anesthesia, hypoesthesia, tickling, crawling, cold sensation, or even pain--without a primary cutaneous condition in a well-defined location that is often caused by nerve trauma, impingement, or irritation. There are multiple types of dysesthesias depending on the body location and the nerves involved. While location, exact symptoms, and etiologies might vary, the underlying theme is that these conditions are of neurologic origin and have dermatologic consequences. Read More

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February 2016

Brachioradial pruritus in a patient with cervical disc herniation and Parsonage-Turner syndrome.

An Bras Dermatol 2015 May-Jun;90(3):401-2. Epub 2015 Jun 1.

Centro Hospitalar do Porto, Porto, Portugal.

Brachioradial pruritus is a chronic sensory neuropathy of unknown etiology which affects the skin of the shoulders, arms and forearms on the insertion of the brachioradialis muscle. We describe the case of a 60-year old woman recently diagnosed with multiple myeloma who refers paresis, severe pruritus and itching lesions on the right arm with 6 months of evolution. Investigation led to a diagnosis of Brachioradial pruritus consequent to the presence of cervical disc herniation and Parsonage-Turner syndrome. Read More

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NK-1 Antagonists and Itch.

Handb Exp Pharmacol 2015 ;226:237-55

Department of Dermatology, Competence Center Chronic Pruritus, University Hospital of Münster, Von-Esmarch-Strasse 58, 48149, Münster, Germany,

Substance P (SP) is an important mediator of pro-inflammatory mechanisms in the skin. It targets multiple cells such as keratinocytes, mast cells, and fibroblasts which are involved in the cutaneous generation of pruritus. This suggests that SP is an interesting target for therapy. Read More

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Capsaicin 8% cutaneous patch: a promising treatment for brachioradial pruritus?

Br J Dermatol 2015 Jun 13;172(6):1669-1671. Epub 2015 Apr 13.

Department of Dermatology, Competence Center Chronic Pruritus, University Hospital of Münster, Münster, Germany.

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Delayed, transient, postsolar truncal pruritus: a report of two cases.

Clin Exp Dermatol 2014 Aug 1;39(6):726-7. Epub 2014 Jul 1.

Welsh Institute of Dermatology, University Hospital of Wales, Cardiff, UK.

We present two cases of a rare clinical condition presenting as a delayed and transient pruritus of the trunk following sun exposure. These cases differ from previously reported conditions such as brachioradial pruritus because of the transient nature and anatomical location of the itching. These two cases extend the clinical spectrum of sun-induced pruritus. Read More

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The role of capsaicin in dermatology.

Prog Drug Res 2014 ;68:293-306

Neurogenic pain and pruritus are the common chief complaints at dermatology office visits. Unfortunately, they are also notoriously difficult conditions to treat. Topical capsaicin used as a single therapy or as an adjuvant offers a low-risk option for patients who do not achieve control on other therapies. Read More

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[Brachioradial pruritus revealing cervicomedullary astrocytoma and treated with 8% capsaicin patches].

Ann Dermatol Venereol 2014 May 24;141(5):374-5. Epub 2014 Feb 24.

Service de dermatologie, CHG de Montauban, 100, rue Léon-Cladel, BP 765, 82013 Montauban cedex, France.

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Similarities between neuropathic pruritus sites and lichen simplex chronicus sites.

Isr Med Assoc J 2014 Feb;16(2):88-90

Background: Localized itch of non-pruritoceptive origin is often neuropathic and may be referred to as neuropathic itch syndrome.

Objectives: To describe the results of nerve conduction studies in patients with anogenital pruritus, brachioradial pruritus and scalp dysesthesia, and compare these sites to typical sites of lichen simplex chronicus (LSC).

Methods: The study summarizes previously published data combined with unpublished data of patients with scalp dysesthesia. Read More

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February 2014

[Secondary generalized brachioradial pruritus. An uncommon but easy-to-use differential diagnostic approach to generalized pruritus].

Hautarzt 2014 Jan;65(1):56-8

Kompetenzzentrum Chronischer Pruritus (KCP), Klinik für Hautkrankheiten, Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland,

Brachioradial pruritus is a neuropathic form of chronic pruritus and mostly localized on the forearms. We report on a patient whose pruritus generalized 4 months after beginning on the forearms. The mechanism that leads to generalization is still unknown; multiplier factors may be involved. Read More

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January 2014