Search our Database of Scientific Publications and Authors

I’m looking for a

    82 results match your criteria Brachioradial Pruritus

    1 OF 2

    Application of an 8% capsaicin patch normalizes epidermal TRPV1 expression but not the decreased intraepidermal nerve fibre density in patients with brachioradial pruritus.
    J Eur Acad Dermatol Venereol 2018 Feb 10. Epub 2018 Feb 10.
    Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
    Background: Topical capsaicin shows efficacy in the treatment of brachioradial pruritus (BRP); however, its mechanisms of action remain unclear.

    Objective: The effect of capsaicin on the epidermis (i.e. Read More

    Aprepitant for the Treatment of Chronic Refractory Pruritus.
    Biomed Res Int 2017 19;2017:4790810. Epub 2017 Sep 19.
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Chronic pruritus is a difficult condition to treat and is associated with several comorbidities, including insomnia, depression, and decreased quality of life. Treatment for chronic itch includes corticosteroids, antihistamines, and systemic therapies such as naltrexone, gabapentin, UV light therapy, and immunomodulatory treatments, including azathioprine, methotrexate, and cellcept. However, some patients still remain refractory to conventional therapy. Read More

    Brachioradial Pruritus and Notalgia Paraesthetica: A Comparative Observational Study of Clinical Presentation and Morphological Pathologies.
    Acta Derm Venereol 2018 Jan;98(1):82-88
    Center for Chronic Pruritus, Department of Dermatology, University Hospital Münster, Von- Esmarch-Str. 58, DE-48149 Münster, Germany.
    Brachioradial pruritus (BRP) and notalgia paraesthetica (NP) represent 2 of the most common neuropathic itch syndromes. A total of 58 consecutive patients presenting at the Center for Chronic Pruritus, University Hospital Münster, were analysed with regard to clinical presentation, anatomical and morphological pathologies, impairment in quality of life, and response to treatment with topical capsaicin. Patients with BRP reported stinging and burning more often than those with NP. Read More

    Impact of drug therapy on brachioradial pruritus.
    An Bras Dermatol 2017 Mar-Apr;92(2):281-282
    Department of Dermatology, Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.
    Few studies have described therapeutic options in brachioradial pruritus. We describe a cross-sectional study of brachioradial pruritus patients treated in an outpatient unit. We reviewed medical records and interviewed brachioradial pruritus patients without indication for decompressive surgery, in order to access the perceptions of intensity of pruritus prior to treatment and response to therapy. Read More

    Pregabalin treatment of three cases with brachioradial pruritus.
    Dermatol Ther 2017 Mar 6;30(2). Epub 2017 Feb 6.
    Department of Physical Medicine and Rehabilitation, Dr. Siyami Ersek Thorax and Cardiaovascular Surgery Training and Research Hospital, İstanbul, Turkey.
    Brachioradial pruritus (BRP) is a rare type of chronic pruritus that usually localized at the dorsolateral part of the forearms. Itching, burning, or pain are common symptoms at the involved areas. The etiological factors are still unknown but sun exposure and/or cervical spine lesions seem to be trigerring or precipiting factors. Read More

    Clinical, epidemiological and therapeutic profile of patients with brachioradial pruritus in a reference service in dermatology.
    An Bras Dermatol 2016 Jul-Aug;91(4):549-51
    Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.
    This is a cross-sectional study, conducted from May to November/2014, in a dermatology reference unit, through review of medical records and interviews. In a sample of 49 patients with brachioradial pruritus, we observed higher prevalence of Caucasian (81.6%) and women (73. Read More

    Brachioradial Pruritus as a Harbinger of Syrinx in Chronic Spinal Cord Injury: A Case Report.
    PM R 2017 Mar 18;9(3):311-313. Epub 2016 Aug 18.
    McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX(†).
    This case describes a 56-year-old man with known thoracic spinal cord injury undergoing evaluation for a pruritic rash on the dorsolateral aspect of his forearms with no upper extremity neuromuscular symptoms. Common diagnoses were considered and treated with little success. The diagnosis of brachioradial pruritus (BRP) was made, and evaluation for possible causes revealed a large cervicothoracic syrinx. Read More

    Cost-effectiveness of an 8% Capsaicin Patch in the Treatment of Brachioradial Pruritus and Notalgia Paraesthetica, Two Forms of Neuropathic Pruritus.
    Acta Derm Venereol 2017 01;97(1):71-76
    Department of Dermatology and Venereology , University Hospital Münster,, DE-48149 Münster, Germany.
    In brachioradial pruritus and notalgia paraesthetica, the 8% capsaicin patch is a novel and effective, but cost-intense, therapy. Routine data for 44 patients were collected 6 months retrospectively and prospectively to first patch application. The cost to health insurance and the patient, and patient-reported outcomes were analysed (visual analogue scale, numerical rating scale, verbal rating scale for pruritus symptoms, Dermatological Life Quality Index, and Patient Benefit Index). Read More

    Cutaneous manifestations in neuro-oncology: clinically relevant tumor and treatment associated dermatologic findings.
    Semin Oncol 2016 06 23;43(3):401-7. Epub 2016 Feb 23.
    Department of Neurology, Wake Forest School of Medicine, Winston Salem, NC; Department of Neurology and Oncology, Johns Hopkins School of Medicine, Baltimore, MD.
    Skin findings are a rare but important aspect of the evaluation and management of patients with tumors of the nervous system. Skin findings have the highest prevalence in genetic tumor syndromes termed neuro-genodermatoses, which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and tuberous sclerosis. Skin changes are observed in patients with non-syndromic nervous system malignancy, often as a result of pharmacotherapy. Read More

    Neurocutaneous disease: Neurocutaneous dysesthesias.
    J Am Acad Dermatol 2016 Feb;74(2):215-28; quiz 229-30
    Department of Dermatology, University of Missouri, Columbia, Missouri. Electronic address:
    Dysesthesia is a generic term for a cutaneous symptom--such as pruritus, burning, tingling, stinging, anesthesia, hypoesthesia, tickling, crawling, cold sensation, or even pain--without a primary cutaneous condition in a well-defined location that is often caused by nerve trauma, impingement, or irritation. There are multiple types of dysesthesias depending on the body location and the nerves involved. While location, exact symptoms, and etiologies might vary, the underlying theme is that these conditions are of neurologic origin and have dermatologic consequences. Read More

    Brachioradial pruritus in a patient with cervical disc herniation and Parsonage-Turner syndrome.
    An Bras Dermatol 2015 May-Jun;90(3):401-2. Epub 2015 Jun 1.
    Centro Hospitalar do Porto, Porto, Portugal.
    Brachioradial pruritus is a chronic sensory neuropathy of unknown etiology which affects the skin of the shoulders, arms and forearms on the insertion of the brachioradialis muscle. We describe the case of a 60-year old woman recently diagnosed with multiple myeloma who refers paresis, severe pruritus and itching lesions on the right arm with 6 months of evolution. Investigation led to a diagnosis of Brachioradial pruritus consequent to the presence of cervical disc herniation and Parsonage-Turner syndrome. Read More

    NK-1 Antagonists and Itch.
    Handb Exp Pharmacol 2015 ;226:237-55
    Department of Dermatology, Competence Center Chronic Pruritus, University Hospital of Münster, Von-Esmarch-Strasse 58, 48149, Münster, Germany,
    Substance P (SP) is an important mediator of pro-inflammatory mechanisms in the skin. It targets multiple cells such as keratinocytes, mast cells, and fibroblasts which are involved in the cutaneous generation of pruritus. This suggests that SP is an interesting target for therapy. Read More

    Delayed, transient, postsolar truncal pruritus: a report of two cases.
    Clin Exp Dermatol 2014 Aug 1;39(6):726-7. Epub 2014 Jul 1.
    Welsh Institute of Dermatology, University Hospital of Wales, Cardiff, UK.
    We present two cases of a rare clinical condition presenting as a delayed and transient pruritus of the trunk following sun exposure. These cases differ from previously reported conditions such as brachioradial pruritus because of the transient nature and anatomical location of the itching. These two cases extend the clinical spectrum of sun-induced pruritus. Read More

    Similarities between neuropathic pruritus sites and lichen simplex chronicus sites.
    Isr Med Assoc J 2014 Feb;16(2):88-90
    Background: Localized itch of non-pruritoceptive origin is often neuropathic and may be referred to as neuropathic itch syndrome.

    Objectives: To describe the results of nerve conduction studies in patients with anogenital pruritus, brachioradial pruritus and scalp dysesthesia, and compare these sites to typical sites of lichen simplex chronicus (LSC).

    Methods: The study summarizes previously published data combined with unpublished data of patients with scalp dysesthesia. Read More

    [Secondary generalized brachioradial pruritus. An uncommon but easy-to-use differential diagnostic approach to generalized pruritus].
    Hautarzt 2014 Jan;65(1):56-8
    Kompetenzzentrum Chronischer Pruritus (KCP), Klinik für Hautkrankheiten, Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland,
    Brachioradial pruritus is a neuropathic form of chronic pruritus and mostly localized on the forearms. We report on a patient whose pruritus generalized 4 months after beginning on the forearms. The mechanism that leads to generalization is still unknown; multiplier factors may be involved. Read More

    Brachioradial pruritus: Mayo Clinic experience over the past decade.
    Br J Dermatol 2013 Nov;169(5):1007-15
    Mayo Medical School, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, U.S.A.
    Background: Brachioradial pruritus (BRP) is a fascinating condition that is seen increasingly often, but any additional data from retrospective observational studies can still enhance our understanding.

    Objectives: To review our experience at the Mayo Clinic with patients presenting with BRP.

    Methods: We retrospectively reviewed the clinical records of patients diagnosed with BRP between 1999 and 2011. Read More

    The neurology of itch.
    Brain 2014 Feb 22;137(Pt 2):313-22. Epub 2013 Jun 22.
    Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0114, USA.
    Research over the past 15 years has helped to clarify the anatomy and physiology of itch, the clinical features of neuropathic itch syndromes and the scientific underpinning of effective treatments. Two itch-sensitive pathways exist: a histamine-stimulated pathway that uses mechanically insensitive C-fibres, and a cowhage-stimulated pathway primarily involving polymodal C-fibres. Interactions with pain continue to be central to explaining various aspects of itch. Read More

    Scalp dysesthesia related to cervical spine disease.
    JAMA Dermatol 2013 Feb;149(2):200-3
    Department of Dermatology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
    Background: Scalp dysesthesia is characterized by abnormal sensations of the scalp in the absence of any other unusual physical examination findings. The pathogenesis of this condition is unknown but has been reported in the setting of underlying psychiatric disorders. Other localized pruritic syndromes, including brachioradial pruritus and notalgia paresthetica, have been associated with pathologic conditions of the spine and have been successfully treated with gabapentin. Read More

    Neuropathic itch: diagnosis and management.
    Dermatol Ther 2013 Mar-Apr;26(2):104-9
    Department of Psychosomatics and Psychotherapy, Competence Center of Chronic Pruritus, University Hospital Münster, 48149 Münster, Germany.
    Chronic pruritus (CP) is a frequent symptom in the general population; in 8% of all patients, it has a neuropathic origin. CP is of neuropathic origin when nerve fiber damage is responsible for the symptom. The damage can be caused by compression or degeneration of the nerve fibers in the skin or extracutaneous in peripheral nerves or the central nervous system. Read More

    Brachioradial pruritus -- descriptive analysis of Brazilian case series.
    J Dtsch Dermatol Ges 2013 Jun 2;11(6):530-5. Epub 2013 Jan 2.
    Dermatology Service of Instituto Lauro de Souza Lima, Brazil.
    Background: The epidemiology and clinical features of brachioradial pruritus are variably described in the literature. We sought to analyze these features in a large group of Brazilian patients.

    Patients And Methods: In a descriptive, observational study, we identified all patients with a final diagnosis of brachioradial pruritus seen over a one-year period and re-trospectively reviewed their records. Read More

    [Brachioradial pruritus effectively treated with gabapentin].
    Ugeskr Laeger 2012 Jun;174(26):1830-1
    Hudafdeling I og Allergicentret, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.
    Brachioradial pruritus is a characteristic clinical condition with a deep intense itching, tingling or burning sensation localized to the dorsolateral part of the upper extremities. The symptoms occur primarily in the late summer in fair skin type people who are extensively sun-exposed. The condition is difficult to treat and does not respond to topical steroids and antihistamines. Read More

    Gabapentin for pruritus in palliative care.
    Am J Hosp Palliat Care 2013 Mar 2;30(2):192-6. Epub 2012 May 2.
    Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
    Itch/pruritus can be very distressing in palliative care population and often is difficult to treat. Conventional antihistamines lack efficacy. Cutaneous and central pathogenesis of itch is extremely complex and unclear, making its treatment challenging. Read More

    Neuropathic itch.
    Semin Cutan Med Surg 2011 Jun;30(2):87-92
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
    Chronic itch can be caused by dysfunctions of itch-sensing neurons that produce sensory hallucinations of pruritogenic stimuli. The cellular and molecular mechanisms are still unknown. All neurological disease categories have been implicated, and neurological causes should be considered for patients with otherwise-unexplained itch. Read More

    Brachioradial pruritus as a result of cervical spine pathology: the results of a magnetic resonance tomography study.
    J Am Acad Dermatol 2011 Oct 8;65(4):756-62. Epub 2011 Jun 8.
    Department of Neurology, University Hospital Münster, Münster, Germany.
    Background: Brachioradial pruritus (BRP) describes a rare form of itching occurring at the dorsolateral part of the forearms. Recent case reports suggest that BRP may be attributed to cervical lesions or spine neoplasms.

    Objective: We sought to determine the incidence of cervical spine changes in BRP and to correlate the localization of spinal lesions with the dermatomal presence of pruritus. Read More

    Systematic review of topical capsaicin in the treatment of pruritus.
    Int J Dermatol 2010 Aug;49(8):858-65
    Complementary Medicine, Peninsula Medical School, University of Exeter and Plymouth, Exeter, UK.
    Objective: To determine the efficacy of topical capsaicin in treating pruritus in any medical condition.

    Data Sources: Cochrane library, Medline, Embase, Cinahl and Amed, up to April 2008. No language restrictions. Read More

    Role of spinal neurotransmitter receptors in itch: new insights into therapies and drug development.
    CNS Neurosci Ther 2011 Dec 15;17(6):742-9. Epub 2010 Oct 15.
    Department of Dermatology, University of California, San Francisco, CA 94143-0660, USA.
    Targets for antipruritic therapies are now expanding from the skin to the central nervous system. Recent studies demonstrate that various neuronal receptors in the spinal cord are involved in pruritus. The spinal opioid receptor is one of the best-known examples. Read More

    Brachioradial pruritus successfully treated with gabapentin.
    J Dermatol 2010 Jul;37(7):662-5
    Faculty of Medicine, Department of Dermatology, Suleyman Demirel University, Isparta, Turkey.
    Brachioradial pruritus (BRP) is a mysterious entity characterized by localized pruritus of the dorsolateral aspect of the arm. The precise etiology of BRP remains unknown, but sun exposure and/or cervical spine lesions seem to be triggering or at least aggravating factors. Many treatment alternatives including non-steroidal anti-inflammatory drugs, topical capsaicin, topical corticosteroids, photoprotection, carbamazepine and acupuncture have been used with different success rates. Read More

    Self-healing photo-neuropathy and cervical spinal arthrosis in four sisters with brachioradial pruritus.
    J Brachial Plex Peripher Nerve Inj 2009 Nov 17;4:21. Epub 2009 Nov 17.
    The cause of brachioradial pruritus (a localized itching on the arms or shoulders) is controversial. The role of sun and cervical spine disease has been discussed. This is a report on four sisters suffering from brachioradial pruritus recurring every summer. Read More

    A C-fiber-mediated neuropathic brachioradial pruritus.
    J Neurosurg 2010 Jul;113(1):118-21
    Brain Research Centre Antwerp for Innovative & Interdisciplinary Neuromodulation and Department of Neurosurgery, University Hospital Antwerp, Edegem, Belgium.
    A 56-year-old man presented to the outpatient clinic with a 3-year history of itch within the innervation territory of C-6 of the left arm. Sudden neck movements induced intermittent paresthesias in the same dermatome. No dermatological diseases, allergies, or trauma to the affected extremity or the spine or a history of familial pruritus were reported. Read More

    [Brachioradial pruritus revealing an ependymoma].
    Ann Dermatol Venereol 2009 May 25;136(5):435-7. Epub 2009 Apr 25.
    Service de dermatologie, CHU de Brest, 29609 Brest cedex, France.
    Background: Brachioradial pruritus is a rare form of pruritus localised to one or more brachioradial dermatomes, initially classified as a photodermatosis but which in fact is generally brought on by nervous compression. We report a case of a brachioradial pruritus revealing an intramedullary tumour.

    Patients And Methods: A 53-year-old man had presented pruritus for seven years under the left clavicle, then on the left forearm followed by the right forearm. Read More

    [Brachioradial pruritus as a symptom of cervical radiculopathy].
    Actas Dermosifiliogr 2008 Nov;99(9):719-22
    Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.
    Brachioradial pruritus is characterized by the presence of pruritus on the lateral aspect of the arms. The etiology of this enigmatic entity is the subject of some debate some authors claim that brachioradial pruritus is a photodermatosis whereas others attribute it to the presence of underlying cervical radiculopathy. In these case reports, we present our experience with brachioradial pruritus and discuss the role of underlying neuropathy in its etiology and that of other types of localized pruritus such as notalgia paresthetica, anogenital pruritus, and burning mouth syndrome. Read More

    A case of neuropathic brachioradial pruritus caused by cervical disc herniation.
    Nat Clin Pract Neurol 2008 Jun 6;4(6):338-42. Epub 2008 May 6.
    Department of Neurological Pain Research and Therapy, Christian-Albrechts University of Kiel, Kiel, Germany.
    Background: A 64-year-old woman presented to an outpatient clinic with a 2-year history of itch, burning sensation and intermittent paresthesias within the innervation territory of the sixth cervical nerve root on the right dorsal forearm. No dermatological diseases, trauma to the affected extremity or the spine, or familial pruritus were reported.

    Investigations: Dermatological examination, skin biopsy, laser Doppler imaging, neurological physical examination and cervical MRI scan. Read More

    Neuropathic and psychogenic itch.
    Dermatol Ther 2008 Jan-Feb;21(1):32-41
    Department of Dermatology, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
    Neuropathic and psychogenic itch are two entities that have not been well studied. Neuropathic itch is related to pathology located at any point along the afferent pathway of the nervous system. It could be related to damage to the peripheral nervous system, such as in postherpetic neuropathy, brachioradial pruritus, notalgia paresthetica, and in central nervous system damage as a result of spinal cord tumors and demyelinization diseases such as multiple sclerosis. Read More

    Brachioradial pruritus: a case report and review of the literature.
    Cutis 2008 Jan;81(1):37-40
    Department of Surgery, Mercer University School of Medicine, Macon, Georgia, USA.
    Brachioradial pruritus is an enigmatic pruritic sensation that characteristically involves the proximal lateral forearm of middle-aged women residing in tropical to temperate climates. There are often no associated cutaneous signs. The pathophysiology has been debated but is believed to involve UV radiation and/or cervical spine disease. Read More

    Recent advances in pathophysiology and current management of itch.
    Ann Acad Med Singapore 2007 Sep;36(9):788-92
    Faculty of Medicine, National University of Singapore, Singapore.
    The neurophysiology of itch, the dominant symptom of skin disease, has previously received scant attention. Recent advances in the neurophysiology and molecular basis of itch include the use of microneurography to demonstrate the existence of a subset of itch-dedicated afferent C neurons distinct from neurons which transmit pain; use of functional positron emission tomography (PET) and magnetic resonance imaging (MRI) of the brain to reveal an itch-specific activation matrix, and new evidence of a functional "dialogue" between C neuron terminals and dermal mast cells in which recently described proteinase-activated receptor type 2 (PAR2) and transient receptor potential vanilloid 1 (TRPV1) receptors, proteases and endovanilloids play a major role. As a necessary prerequisite to diagnosis and management, a pathophysiologically based classification of itch is proposed. Read More

    Brachioradial pruritus--a peculiar neuropathic disorder.
    Clin Neurol Neurosurg 2006 Dec 19;108(8):803-5. Epub 2006 Jan 19.
    Department of Neurology, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
    The case is presented of a middle-aged woman who suffered from lancinating itch on the dorsolateral aspect of the upper arm after a loco-regional injury, first on the right and later on the left side. Brachioradial pruritus (BRP) was diagnosed. Neurophysiologic examination was compatible with a neuropathy at the C5-C6 level, while a negative nerve root block supported an additional central impact. Read More

    Familial brachioradial pruritus.
    Br J Dermatol 2005 Nov;153(5):1016-8
    Department of Dermatology, University Hospital, SE-221 85 Lund, Sweden.
    Background: The cause of brachioradial pruritus (a localized itching on the arms or shoulders) is controversial. A hereditary form of this condition has not been reported.

    Objectives: To describe the occurrence of brachioradial pruritus in several members of one family. Read More

    1 OF 2