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Cureus 2022 May 3;14(5):e24712. Epub 2022 May 3.

Dermatology, Mayo Clinic, Rochester, USA.

Bowenoid papulosis is an uncommon skin disorder usually seen in the genital area and associated with human papillomavirus (HPV) infection. Clinically, patients usually present with solitary or multiple skin- to brown-colored papules. Plaque morphology of lesions and extragenital location are unusual. Read More

Photodiagnosis Photodyn Ther 2022 May 23:102918. Epub 2022 May 23.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Background: Bowenoid papulosis (BP) is a rare infectious skin disease that occurs in sexually active young people. BP is associated with human papillomavirus (HPV)16 and 18 infections, spreads through sexual contact, and tends to become cancerous. Currently, there are different BP treatment methods, and few reports on the efficacy of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) (ALA-PDT). Read More

Australas J Dermatol 2022 May 11. Epub 2022 May 11.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Genital keratotic lesions include bowenoid papulosis (BP), which histologically resembles squamous cell carcinoma in situ containing high-risk HPV, condyloma acuminatum (CA) that is a genital wart containing mostly low-risk HPV, and genital seborrheic keratosis (GSK), which is a benign epidermal tumour lacking a clear etiologic relationship with HPV. This study compared HPV genotype distributions among BP, CA and GSK and revealed that BP and GSK were related to high-risk HPV whereas CA was related to low-risk HPV. It is plausible that GSK is a distinct epidermal tumour often related to high-risk HPV rather than merely a senescent form of CA considering the overall discrepancy in the frequency distribution of HPV genotypes along with histopathological differences, and the detection of high-risk HPV in GSK alerts physicians to consider more active treatment and continued follow-ups. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2021 Sep;30(3):117-121

Department of Dermatology, School of Medicine, University of Patras, Patras, Greece.

In an attempt to raise awareness among physicians of the importance of early diagnosis and treatment of penile cancer and its precursor lesions, we report the unique case of a male patient with condylomata acuminata, Bowenoid papulosis, and squamous cell carcinoma, all HPV 16/18-positive, coexisting in his genital area. Read More

Turk Patoloji Derg 2022 ;38(1):54-59

Department of Dermatology &Venereology, Istanbul University, Istanbul Faculty of Medicine, ISTANBUL, TURKEY.

Secondary localized cutaneous amyloidosis is a histopathological finding seen in the dermis, in various benign, premalignant, and malignant skin conditions, without clinical significance. The real incidence is not known. We aimed to investigate the phenomenon of secondary localized cutaneous amyloidosis in Bowen's disease and Bowenoid papulosis. Read More

Photodiagnosis Photodyn Ther 2021 Dec 19;36:102448. Epub 2021 Jul 19.

Department of Dermatology, Kosin University College of Medicine, Busan, South Korea. Electronic address:

Dermatologists often encounter keratotic or warty lesions in the genital area. Establishing a clear diagnosis may seem challenging, particularly when the differential diagnosis includes bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum. This study aimed to compare the dermoscopic features of bowenoid papulosis (BP), seborrheic keratosis, and condyloma acuminatum in the genital area. Read More

Ann Dermatol 2020 Dec 11;32(6):512-515. Epub 2020 Nov 11.

Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Epidermolytic acanthoma (EA) is a rare benign tumor, which usually appears as a solitary small papule. However, there are a few case reports of multiple EA, most of which occurs on the genital area. Cases of multiple EA may mimic verruca vulgaris, condyloma accuminatum, seborrheic keratosis, and bowenoid papulosis, and therefore, can be easily misdiagnosed. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2021 Mar;30(1):39-41

Department of Dermatology and Venereology, Faculty of Medicine, Trakya University, Edirne, Turkey.

Bowenoid papulosis is an uncommon precancerous condition of the genitalia caused by oncogenic human papillomavirus types. It is seen in young, sexually active adults and histologically resembles Bowen's disease. Dermoscopy is useful in the diagnosis of both pigmented and non-pigmented skin lesions, but dermoscopic diagnostic accuracy criteria have not yet developed in diseases such as bowenoid papulosis and Bowen's disease. Read More

Int J Dermatol 2021 Jun 27;60(6):712-716. Epub 2021 Feb 27.

Mater Misericordiae Hospital, Brisbane, Queensland, Australia.

Background: Genital skin malignancies are a rare entity encountered by clinicians that may result in significant morbidity and mortality. Lack of familiarity or expertise in this area among clinicians can delay appropriate management of these conditions and may result in disease progression.

Methods: We performed a retrospective descriptive cohort study of male patients who received a genital skin biopsy reported by one major dermatopathology laboratory between January 2017 and December 2018 with a histological diagnosis of a premalignant or malignant condition. Read More

Int J STD AIDS 2021 04 12;32(5):388-395. Epub 2021 Feb 12.

Dermatology Department, University College Hospital, Chelsea and Westminster Hospital, London, UK.

Background: The pathogenesis of penile intraepithelial neoplasia (PeIN) is unclear but human papillomavirus (HPV) infection and polymorphisms in human leucocyte antigen (HLA).

Objectives: To examine the prevalence of HPV DNA and HLA in PeIN.

Methods: Adult Caucasian men with a clinical and histological diagnosis of PeIN, that is, Bowenoid papulosis (BP), Bowen's disease of penis (BDP) and erythroplasia of Queyrat (EQ) were selected and phenotyped from the clinical records. Read More

Gynecol Obstet Fertil Senol 2021 06 6;49(6):538-546. Epub 2020 Nov 6.

Institut Curie Saint-Cloud, 35, rue Dailly, 92210 Saint-Cloud, France; Université de Versailles-Saint-Quentin-en-Yvelines, UFR sciences de la santé, Versailles, France. Electronic address:

Vulvar carcinomas represent 4% of all gynaecological cancers with 838 new cases in France in 2018. The precursor lesions of vulvar carcinomas are differentiated vulvar intraepithelial lesion (dVIN) in a context of lichen sclerosus and vulvar high-grade squamous intraepithelial lesion (HSIL) link to human papillomavirus (HPV) infection. Three typical clinical forms of HSIL are described: the Bowenoid papulosis, the Bowen's disease and the confluent VIN. Read More

Photodiagnosis Photodyn Ther 2021 Mar 4;33:102078. Epub 2020 Nov 4.

Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou 510091, China.

Aims And Background: High-risk human papillomavirus (HR-HPV) infection has been confirmed to be highly related to diseases such as Bowenoid papulosis, cervical cancer, and cervical intraepithelial neoplasia. 5-aminolevulinic acid-mediated PDT (ALA-PDT) has been used in a variety of HR-HPV infection-related diseases. Dihydroartemisinin (DHA) is one of artemisinin derivatives, and has inhibitory effects on a variety of cancer cells. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Aug;45(8):988-993

Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410043, China.

Objectives: Reflection confocal microscopy (RCM) is commonly used to assist in the diagnosis of skin diseases. RCM has been found to be useful in the diagnosis of genital warts. The characteristics of genital warts under RCM are not specific. Read More

J Dermatolog Treat 2022 Mar 6;33(2):1047-1062. Epub 2020 Aug 6.

Department of Dermatology, University College London Hospitals, London, UK.

Introduction: Penile intraepithelial neoplasia (PeIN) is a histological term for precancerous penile lesions. PeIN is important due to the high morbidity and mortality associated with progression to penile squamous cell carcinoma (PSSC). But PeIN is rare, contributing to a limited evidence-base for the relative efficacy of available treatment options. Read More

Case Rep Dermatol 2020 May-Aug;12(2):98-106. Epub 2020 May 15.

Department of Medicine and Medical Specialties, University of Alcalá, Madrid, Spain.

Pigmented Bowen's disease is a rare variant of in situ squamous skin cell carcinoma. It mainly affects patients between 60 and 70 years of age. Its clinical features include well-demarcated, pigmented plaque arising in photo-exposed areas of the body. Read More

Photodermatol Photoimmunol Photomed 2020 05 27;36(3):251-253. Epub 2020 Feb 27.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Indian J Sex Transm Dis AIDS 2019 Jul-Dec;40(2):168-171

Department of Dermatology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India.

squamous cell carcinoma (SCC) of male and female genitalia can present as Bowen's disease (BD), erythroplasia of Queyrat, Bowenoid papulosis, Paget's disease, pseudoepitheliomatous keratotic, and micaceous balanitis. BD is SCC . It affects both skin and mucous membranes and has the potential to progress to invasive SCC. Read More

Indian J Sex Transm Dis AIDS 2019 Jul-Dec;40(2):97-104

Department of Skin and VD, Shree Krishna Hospital, Karamsad, Gujarat, India.

The spectrum of conditions affecting the penile skin is varied and ranges from simple, benign dermatoses to premalignant and malignant conditions. Anogenital malignancies and premalignancies are an important personal/public health problem due to their effects on individuals' physical, mental, and sexual health. Furthermore, due to their etiological association with human papillomavirus infection, anogenital malignancies, and premalignancies constitute an immense public health burden. Read More

Photodiagnosis Photodyn Ther 2020 Mar 20;29:101635. Epub 2019 Dec 20.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Background: Bowenoid papulosis is a polymorphic papular disease that occurs on the external genital area. We investigated the efficacy of 5-aminolevulinic acid-mediated photodynamic therapyin the treatment of Bowenoid papulosis.

Methods: We investigated 200 Bowenoid papulosis cases from the Department of Dermatology and Venereology of Nanfang Hospital in 2016-2018. Read More

Case Rep Dermatol 2019 Sep-Dec;11(3):310-316. Epub 2019 Nov 7.

Medical Department Cantabria Labs Difa Cooper, Caronno Pertusella, Italy.

Polyphenon E 10%, a green tea extract containing epigallocatechin gallate (EGCG) as the main active compound, is a topical formulation indicated for the treatment of genital warts. Polyphenon E has also shown to be very effective in the treatment of periungual and plane warts. Here, we report a dramatic clinical effect of topical treatment with polyphenon E in a subject with multiple "seborrheic keratosis-like" lesions of the genital area. Read More

J Cutan Pathol 2020 Mar 30;47(3):257-262. Epub 2019 Sep 30.

Department of Oral Medicine (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil.

Bowenoid papulosis (BPap) is an uncommon skin disorder linked to human papillomavirus (HPV) infection and characterized clinically by the presence of scattered papules or small plaques, multiple and pigmented, that involve the stratified squamous epithelium. Bowen disease (BD) is recognized as the main differential diagnosis of BPap. An 80-year old white woman was referred for the evaluation of multiple, brown verrucous papules measuring 3 to 4 mm in diameter on the right maxillary gingiva. Read More

Actas Dermosifiliogr (Engl Ed) 2020 Jan 25;111(1):76-77. Epub 2019 Sep 25.

Servicio de Dermatología, Hospital do Meixoeiro, EOXI, Vigo, Pontevedra, España.

Clin Colon Rectal Surg 2019 Sep 22;32(5):347-357. Epub 2019 Aug 22.

Department of Surgery, Centro de Educación Médica e Investigaciones clínicas, Buenos Aires, Argentina.

This article addresses the natural history of the human papilloma virus (HPV) infection to anal squamous intraepithelial lesions, and onto squamous cell carcinoma of the anus. This article provides overviews of the virology, pathophysiology, nomenclature, classification, historical terms, risk factors, clinical evaluation, differential diagnosis, and treatment of HPV infection and its sequelae. Read More

Int J STD AIDS 2019 04 4;30(5):522-525. Epub 2019 Feb 4.

Department of Dermatology & Venereology, Govt. Medical College, Thrissur, Kerala.

Bowenoid papulosis (BP) is a premalignant condition usually caused by oncogenic types of human papillomavirus (HPV) presenting clinically as warty genital papules. Adult T-cell leukaemia-lymphoma (ATLL) is a peripheral T-cell leukaemia-lymphoma caused by the retrovirus, human T-cell lymphotropic virus 1 (HTLV-1). We report a case of BP initially mistaken as genital warts; on detailed evaluation the patient had features of chronic immunosuppression. Read More

Australas J Dermatol 2019 Aug 25;60(3):e201-e207. Epub 2018 Dec 25.

Department of Dermatology, University College London Hospital, London, UK.

Background/objectives: The clinical diagnosis of penile intraepithelial neoplasia is challenging. No specific dermoscopic criteria for penile intraepithelial neoplasia have been described in the literature. This study aimed to describe and evaluate the dermoscopic features of penile intraepithelial neoplasia. Read More

J Dermatol 2019 Jun 20;46(6):e192-e193. Epub 2018 Dec 20.

Department of Dermatology, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.

Cutis 2018 Nov;102(5):E27-E29

Division of Anatomic Pathology, Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.

Int J Urol 2019 03 3;26(3):353-357. Epub 2018 Dec 3.

Department of Urology, University Medical Center Utrecht, Utrecht, the Netherlands.

Objective: To determine the incidence of penile intraepithelial neoplasia in the Netherlands using a nationwide histopathology registry and to discuss the nomenclature of premalignant penile lesions.

Methods: Data from patients in the Netherlands diagnosed with a premalignant penile lesion between January 1998 and December 2007 were collected from the nationwide histopathology registry (PALGA); this database covers all pathology reports of inhabitants in the Netherlands. The premalignant lesions included were erythroplasia of Queyrat; Bowen's disease; bowenoid papulosis; mild, moderate and severe dysplasia; and carcinoma in situ of the penis. Read More

J Dermatol 2019 Apr 11;46(4):e137-e138. Epub 2018 Sep 11.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.