Curr Urol Rep 2017 Aug;18(8):62

Virginia Mason Medical Center, Seattle, WA, USA.

Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

J Low Genit Tract Dis 2017 Jul;21(3):e30-e32

1Department of Pathology and Laboratory Medicine, Wexner Medical Center at The Ohio State University, Columbus, OH; and 2Department of Obstetrics and Gynecology, Wexner Medical Center at The Ohio State University, Columbus, OH.

Ann Dermatol Venereol 2017 Mar 20;144(3):220-224. Epub 2017 Jan 20.

Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.

G Ital Dermatol Venereol 2016 Sep 6. Epub 2016 Sep 6.

Clinica Dermatologica, La Sapienza University of Rome, Rome, Italy -

Pathologists who find ectopic glands on the glans and/or on the prepuce, often describe them as Tyson's glands. In this regard, the term Tyson's glands can be replaced by two different descriptive expressions: papillomatosis corona penis and ectopic sebaceous glands. A 15-year old Caucasian male patient presented to our Institute with multiple and asymptomatic circular skin colored-to-yellowish papules at the level of the foreskin, also affecting the shaft of the penis, where they assumed a linear feature. Read More

Postepy Dermatol Alergol 2016 Apr 16;33(2):146-8. Epub 2016 May 16.

Department of Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Proc (Bayl Univ Med Cent) 2016 Apr;29(2):198-9

Texas A&M Health Science Center College of Medicine, Temple, Texas (Fletcher, Ramamurthi, Parekh) and Department of Dermatology, Baylor Scott & White, Temple, Texas (Fletcher, Parekh).

Epidermolytic hyperkeratosis is a histological reaction pattern seen in a variety of disease processes, including epidermolytic ichthyosis, Vorner's epidermolytic palmoplantar keratoderma, epidermal nevus, and solitary epidermolytic acanthoma. Here we present the case of a 59-year-old woman with multiple asymptomatic papules on her vulva. Clinical differential diagnoses included condyloma acuminata, seborrheic keratoses, bowenoid papulosis, adnexal tumors, and papular acantholytic dyskeratosis. Read More

Australas J Dermatol 2017 May 8;58(2):86-92. Epub 2016 Mar 8.

Department of Dermatology, Mater Misericordiae Hospital, Brisbane, Queensland, Australia.

Penile intraepithelial neoplasia (PIN), or penile squamous cell carcinoma in situ, is a rare disease and may be associated with high morbidity and mortality. In an attempt to avoid surgical intervention, which may result in poor cosmetic and functional outcomes for patients, many non-invasive treatments have been trialled with variable success rates. This review summarises the available literature describing the use of topical imiquimod for PIN. Read More

J Cutan Pathol 2016 Apr 10;43(4):347-53. Epub 2016 Feb 10.

Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.

Background: The GATA family of transcription factors is an essential regulator of cellular proliferation and differentiation. In the skin, GATA-3 is critical for epidermal stratification and maintenance of barrier function. A role for GATA-3 in the development of human cutaneous squamous cell carcinoma (SCC) is not known. Read More

Dermatol Pract Concept 2015 Oct 31;5(4):39-42. Epub 2015 Oct 31.

Ackerman Academy of Dermatopathology, New York, NY, USA.

Indian J Sex Transm Dis 2015 Jul-Dec;36(2):223-5

Department of Pathology, Melaka Manipal Medical College, Manipal, Karnataka, India.

An Bras Dermatol 2015 May-Jun;90(3):397-9. Epub 2015 Jun 1.

Complexo Hospitalar Padre Bento de Guarulhos, Guarulhos, SP, Brazil.

Traumatic neuromas are tumors resulting from hyperplasia of axons and nerve sheath cells after section or injury to the nervous tissue. We present a case of this tumor, confirmed by anatomopathological examination, in a male patient with history of circumcision. Knowledge of this entity is very important in achieving the differential diagnosis with other lesions that affect the genital area such as condyloma acuminata, bowenoid papulosis, lichen nitidus, sebaceous gland hyperplasia, achrochordon and pearly penile papules. Read More

Indian J Dermatol Venereol Leprol 2015 Mar-Apr;81(2):219-20

Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, Zhejiang Province, People's Republic of China.

Am J Dermatopathol 2015 Jun;37(6):462-8

*Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; †Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan; ‡Department of Cosmetic Applications and Management, Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan; and §Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan.

The bowenoid transformation of seborrheic keratosis (SK) has rarely been reported. The purpose of this study is to identify their diagnostic immunohistochemical features and association with human papillomavirus (HPV) infection. Skin biopsy specimens of the phenomenon were retrieved from 2001 to 2010. Read More

Pathologe 2015 Feb;36(1):16-29

Heinz-Werner-Seifert-Institut für Dermatopathologie, Trierer-Str. 70-72, 53115, Bonn, Deutschland.

Actinic (solar) keratosis is an intraepidermal squamous neoplasm of sun-damaged skin and by far the most frequent neoplastic skin lesion. A subdivison into three grades has been proposed with increasing acceptance not least because of the therapeutic consequences. The transition to invasive squamous cell carcinoma is reported in 5-10 % and with immunosuppression in 30 % of patients. Read More

Dermatol Pract Concept 2014 Oct 31;4(4):61-3. Epub 2014 Oct 31.

Dermatology Section, Instituto de Investigaciones Médicas "A. Lanari", University of Buenos Aires, Argentina.

Bowenoid papulosis (BP) corresponds to an in situ squamous cell carcinoma (SCC) located in the anogenital region. It is related to HPV, and presents with gray-brown elevated papules or plaques. A biopsy is needed to confirm the diagnosis; however, dermoscopy may be useful to differentiate this disease from other conditions, such as genital warts, seborrheic keratosis and lichen planus. Read More

J Drugs Dermatol 2014 Aug;13(8):901-2

Br J Dermatol 2014 Oct 30;171(4):779-85. Epub 2014 Sep 30.

Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Background: The association between human papillomavirus (HPV) and squamous cell carcinoma (SCC) has been reported; however, the prevalence of HPV infection varies, and the clinical characteristics of HPV-positive cases remain unknown.

Objectives: To elucidate the frequency of HPV infection in a series of Japanese patients with SCC and to identify the characteristics of HPV-positive cases.

Methods: We evaluated 38 patients with SCC treated at our department. Read More

Ann Dermatol 2014 Jun 12;26(3):381-4. Epub 2014 Jun 12.

Department of Dermatology, Yeungnam University College of Medicine, Daegu, Korea.

Bowenoid papulosis (BP) is a disease that mainly occurs in sexually active young adults. The patients present with multiple pigmented papular lesions with a verrucous surface on the anogenital area. Although extragenital BP is usually associated with concomitant genital involvement, a few cases of isolated extragenital BP have been reported. Read More

J Dermatol 2014 Jun;41(6):545-6

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

A 24-year-old healthy Japanese female was diagnosed as having bowenoid papulosis in the genital area. The histopathological findings revealed acanthosis, papillomatosis, dyskeratotic cells and clumping cells with mild atypical nuclei. Human papillomavirus type 16 was detected in the lesion. Read More

Int J STD AIDS 2014 Aug 14;25(9):615-26. Epub 2014 May 14.

Department of Dermatology, Havenziekenhuis, Rotterdam, The Netherlands.

Balanoposthitis can be caused by a disparate range of conditions affecting the penile skin. This guideline concentrates on a selected group of conditions and offers recommendations on the diagnostic tests and treatment regimens needed for the effective management of balanoposthitis. Read More

Dermatol Online J 2014 Apr 16;20(4):22337. Epub 2014 Apr 16.

Saudi Aramco Medical Services Organization, Saudi Arabia.

Patients with HIV have higher risk of developing squamous cell carcinoma of the skin given the increased risk of HPV infection, which alters cell proliferation and apoptosis [1]. Pigmented Bowen's disease is an uncommon form of squamous cell carcinoma in-situ characterized by pigmented lesions that can clinically mimic superficial spreading melanoma, pigmented basal cell carcinoma, melanocytic nevus, Bowenoid papulosis, and seborrheic keratosis. Read More

Curr Probl Dermatol 2014 13;45:92-7. Epub 2014 Mar 13.

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Keratinocytes react to human papillomavirus (HPV) infection by proliferation resulting in different clinical manifestations ranging from flat warts to common warts and cauliflower-like or filiform warts. The clinical presentation may vary according to the HPV type and anatomical site. Although warts are usually a self-limiting disease, some HPV subtypes may induce malignant changes. Read More

Ann Dermatol Venereol 2014 Mar 6;141(3):181-5. Epub 2013 Dec 6.

Service de dermatologie, CHU de Poitiers, 2, rue de la Milétrie, 86000 Poitiers, France.

Background: Pain is the main adverse effect of photodynamic therapy (PDT) and few effective analgesic methods are currently available. Our aim was to evaluate the efficacy of hypnoanalgesia with the use of PDT.

Patients And Methods: Between August 2011 and February 2013, a hypnoanalgesia session was proposed to patients requiring PTD for the treatment of (pre)carcinomatous lesions. Read More

J Dermatol 2014 Apr 24;41(4):337-9. Epub 2014 Feb 24.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

We herein report a case of pigmented condyloma acuminatum in the genital region. A histopathological examination revealed keratinocyte proliferation, papillomatosis and basal pigmentation. Cellular atypia was rarely observed. Read More

Eur J Dermatol 2013 Sep-Oct;23(5):729-30

Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

Biomed Res Int 2013 19;2013:421205. Epub 2013 Aug 19.

Department of Pathology, College of Medicine, Hallym University Sacred Heart Hospital, 896 Pyungchon-Dong, Dongan-Ku, Anyang 431-070, Republic of Korea.

Human papillomavirus (HPV) infection has been demonstrated in some of the nonmelanoma skin cancers as well as in precancerous lesions. Multiple infections of mucosal high-risk HPV may contribute to the onset of digital Bowen's disease through, if any, digital-genital transmission. We screened for the presence of the mucosal HPV DNA in patients with extragenital Bowen's disease (n = 30), squamous cell carcinoma (n = 11), bowenoid papulosis (n = 9), verrucous carcinoma (n = 1), actinic keratosis (n = 5), and basal cell carcinoma (n = 5). Read More

Dermatol Online J 2013 May 15;19(5):18185. Epub 2013 May 15.

A healthy 28-year-old man presented with a 3 month history of multiple papules on the penis that was confirmed as bowenoid papulosis by biopsy. He declined any therapy, but complete resolution was noted 3 months later without any intervention. Read More

Clin Dermatol 2013 Jul-Aug;31(4):362-73

Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, 34098 Istanbul, Turkey.

Anogenital malignancies and premalignancies are an important personal/public health problem due to their effects on individuals' physical, mental, and sexual health. Also, due to their etiological association with human papillomavirus (HPV) infection, anogenital malignancies and premalignancies constitute an immense public health burden. In addition to HPV infection, immunosuppression, HIV infection, chronic dermatoses, such as lichen sclerosis, previous radiotherapy and chemotherapy treatments, and smoking, are the other important etiopathologic factors in the development of anogenital malignancies and premalignancies. Read More

J Am Acad Dermatol 2013 Sep 21;69(3):444-9. Epub 2013 May 21.

Ackerman Academy of Dermatopathology, New York, New York 10016, USA.

Background: The histopathological and clinical overlapping features between condyloma acuminata and bowenoid papulosis can present a diagnostic challenge and we sought to determine if immunochemistry can be helpful in this setting.

Objective: In this study, we evaluate the specificity and sensitivity of p16 immunohistochemistry in condyloma and bowenoid papulosis lesions compared with uninvolved perilesional skin and discuss the possible clinical implications.

Methods: A total of 36 skin biopsy specimens (24 samples of condyloma and 12 samples of bowenoid papulosis with adjacent uninvolved perilesional skin) were stained with an antibody to p16 protein. Read More

Internist (Berl) 2013 Jun;54(6):671-82

Klinik für Dermatologie, Venerologie und Allergologie, Hauttumorcentrum, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Precancerous skin lesions and carcinomas in situ of the skin represent the early stages of epithelial skin tumors. There is no invasive tumor growth, so the basement membrane is completely intact. These lesions show a wide variation of clinical and histological appearances on the skin or mucosa. Read More

Actas Dermosifiliogr 2013 Dec 30;104(10):932-4. Epub 2013 Jan 30.

Servicio de Dermatología, Hospital Municipal de Badalona, Badalona Serveis Assistencials, Barcelona, España. Electronic address:

Actas Dermosifiliogr 2013 Dec 21;104(10):934-6. Epub 2013 Jan 21.

Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, España. Electronic address:

J Cutan Pathol 2013 Feb;40(2):209-10

Acta Histochem 2013 May 6;115(4):339-43. Epub 2012 Oct 6.

Department of Dermatology, The Third Affiliated Hospital of Suzhou University, Jiangsu, Changzhou 213003, China.

Human papillomavirus (HPV) incorporates high-risk HPV (hrHPV) and low-risk HPV (lrHPV) subtypes according to its contribution to oncogenesis. Different HPV subtypes could regulate the cell cycle of infected cells at different levels. To date, the expression of cyclin D1 and cyclin E in Bowenoid papulosis (BP) tissues and its association with HPV infection still remains elusive. Read More

Photochem Photobiol Sci 2013 Jan;12(1):158-65

Piergiacomo Calzavara-Pinton, Department of Dermatology, University of Brescia, Piazzale Spedali Civili 1, I-25123 Brescia, Italy.

Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) has been suggested as a useful treatment option in a number of skin tumors, other than approved indications, and infections. However, evidence is poor because it is mainly supported by isolated case reports or small case series, often with conflicting results. To assess the effectiveness, tolerability and safety of off-label MAL-PDT in daily clinical practice in 20 Italian hospitals, a retrospective observational study of medical records of patients treated for off-label oncologic and infectious skin conditions was carried out. Read More

Acta Derm Venereol 2013 Mar;93(2):228-9

Int J Dermatol 2012 Jul;51(7):804-8

Department of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan.

Background: Human papillomavirus (HPV) is known to cause cervical cancer. Because it has been detected in lesions of Bowenoid papulosis, Bowen's disease, and Bowen's carcinoma, HPV infection has been implicated in the pathogenesis of these diseases.

Methods: A 44-year-old man was diagnosed clinicopathologically with Bowen's carcinoma of the right great toe. Read More

Am J Dermatopathol 2012 Dec;34(8):813-7

Department of Dermatology, Clinical Center for Infectious Skin Diseases, No.1 Hospital of Wuhan, Wuhan, Hubei Province, China.

In the present study, we aim to evaluate the application potential of a combined assay of human telomerase reverse transcriptase (hTERT) and E6 oncoprotein in screening the virus-infected keratinocytes with higher telomerase activity in human papillomaviruses (HPV) 16- and 18-related bowenoid papulosis (BP). HPV16/18 DNA in BP (n = 123) was identified by in situ hybridization, the expression of hTERT and E6 in HPV16/18-related BP (n = 68) was determined by immunohistochemistry. We demonstrated that the expression of hTERT correlated well with that of E6 oncoprotein in HPV16/18-related BP lesions (Spearman rho = 0. Read More

Eur J Dermatol 2012 Mar-Apr;22(2):267-8

J Dermatol 2012 Oct 5;39(10):862-3. Epub 2012 Jan 5.

Ann Dermatol 2011 Nov 3;23(4):493-6. Epub 2011 Nov 3.

Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea.

We report the case of a 23-year-old woman who developed bowenoid papulosis of the vulva and subsequent periungual Bowen's disease. She had a history of a long standing periungual wart on her right thumb before the outbreak of periungual Bowen's disease. By HPV DNA chip, human papillomavirus (HPV) 11, 18 and 31 were identified from the periungual lesions, and HPV 11, 18 and 33 from the vulvar lesion. Read More

J Dermatol 2012 Jul 5;39(7):646-9. Epub 2011 Dec 5.

Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):145-54

St John's Institute of Dermatology, St Thomas Hospital, London, UK.

Human papillomaviruses (HPVs) are small DNA viruses of the papovavirus family, with more than 100 types already described. Their importance in human disease cannot be overemphasized because these agents are among the most common pathogens in cutaneous infectious diseases and are very important in a subset of predominantly, but not exclusively, genital squamous-cell carcinomas. HPVs can be associated with a variety of cutaneous as well as mucosal manifestations. Read More

Prog Urol 2011 Mar;21 Suppl 2:S50-2

Service d'Urologie, CHU d'Angers, 4 rue Larrey, 49933 Angers Cedex, France.

Penile squamous cell carcinoma is a highly evolving tumor. Thus an early diagnosis is a major matter in order to avoid tumoral spread and mutilating surgery. Intra-epithelial neoplasia is a carcinoma in situ involving a disorganized cytological structure and intraepithelial architecture without any change on the derma. Read More

Cutis 2010 Dec;86(6):278, 295-6

Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA.

J Eur Acad Dermatol Venereol 2011 Aug 28;25(8):885-95. Epub 2011 Jan 28.

Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Anogenital pre-malignancies and malignancies are frequently encountered. Aetiopathogenetically, human papillomavirus (HPV) infection plays a critical role. However, there is a variable degree of association of HPV infection with the development of anogenital malignancies. Read More

Med Glas (Zenica) 2010 Aug;7(2):89-95

University Department of Dermatology and Venereology, Zagreb University Hospital Centre and Zagreb University School of Medicine, Zagreb, Croatia.

Anogenital infections caused by Human papillomavirus (HPV) are the most frequently diagnosed sexually transmitted infections of viral origin and up to 150 HPV DNA types have been recognized so far. Anogenital warts (condylomata acuminata) are the most common lesions presented in men, however, during the last decade the other HPV-associated exaggerated lesions such as condylomata plana, penile, scrotal, and anal intraepithelial neoplasias, as well as the penile, urine bladder and prostate cancer have been studied somewhat more extensively. The clinical variations might range from clinically invisible, asymptomatic lesions to the bizarre forms of giant condyloma of Buschke-Löwenstein type, including Bowenoid papulosis, Mb. Read More

Eur J Dermatol 2010 Nov-Dec;20(6):819-20. Epub 2010 Oct 26.

Mod Pathol 2011 Jan 17;24(1):90-7. Epub 2010 Sep 17.

Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA.

The inherent longetivity of stem cells causes them to be susceptible to multiple genetic hits. Thus, it is not surprising that stem cells are implicated in the etiopathogenesis of select cutaneous neoplasms. However, most studies to date are restricted to the use of a single marker (p63, cytokeratin-15 or cytokeratin-19) and do not appear to compare distribution of stem cell markers in a spectrum of cutaneous in situ versus invasive epithelial malignancies. Read More

BMC Cancer 2010 Mar 27;10:118. Epub 2010 Mar 27.

Department of Dermatology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, Tokyo, 113-8603, Japan.

Background: The clinical course of human papillomavirus (HPV) associated with Bowenoid papulosis and condyloma acuminatum of anogenital tumors are still unknown. Here we evaluated molecules that are relevant to cellular proliferation and regulation of apoptosis in HPV associated anogenital tumors.

Methods: We investigated the levels of telomerase activity, and inhibitor of apoptosis proteins (IAPs) family (c-IAP1, c-IAP2, XIAP) and c-Myc mRNA expression levels in 20 specimens of Bowenoid papulosis and 36 specimens of condyloma acuminatum in anogenital areas. Read More