4,582 results match your criteria Bowen Disease


Monitoring tumour burden and therapeutic response through analysis of circulating tumour DNA and extracellular RNA in multiple myeloma patients.

Leukemia 2019 Apr 16. Epub 2019 Apr 16.

Myeloma Research Group, Australian Centre for Blood Diseases, Alfred Hospital-Monash University, Melbourne, VIC, Australia.

Monitoring tumour burden and therapeutic response through analyses of circulating cell-free tumour DNA (ctDNA) and extracellular RNA (exRNA) in multiple myeloma (MM) patients were performed in a Phase Ib trial of 24 relapsed/refractory patients receiving oral azacitidine in combination with lenalidomide and dexamethasone. Mutational characterisation of paired BM and PL samples at study entry identified that patients with a higher number of mutations or a higher mutational fractional abundance in PL had significantly shorter overall survival (OS) (p = 0.005 and p = 0. Read More

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http://dx.doi.org/10.1038/s41375-019-0469-xDOI Listing

A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: new insights for improved secondary prophylaxis strategies.

J Antimicrob Chemother 2019 Apr 15. Epub 2019 Apr 15.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.

Background: Benzathine benzylpenicillin G (BPG) is recommended as secondary prophylaxis to prevent recurrence of acute rheumatic fever and subsequent rheumatic heart disease (RHD). Following intramuscular injection, BPG is hydrolysed to benzylpenicillin. Little is known of the pharmacokinetics of benzylpenicillin following BPG in populations at risk of RHD. Read More

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http://dx.doi.org/10.1093/jac/dkz076DOI Listing
April 2019
2 Reads

METHYL AMINOLEVULINATE-BASED PHOTODYNAMIC THERAPY OF BOWEN´S DISEASE: OBSERVATIONAL STUDY OF 21 LESIONS.

Photodiagnosis Photodyn Ther 2019 Apr 12. Epub 2019 Apr 12.

Private clinic of Dr. Alberdi, Madrid, Spain.

Background: Although surgical removal is the treatment of choice in Bowen's disease (BD), there are cases in which by age, comorbidities, use of anticoagulants, location, cosmetic result, or size, it is preferable to use other alternative treatments such as cryotherapy, 5-fluorouracil cream, imiquimod 5% cream or photodynamic therapy (PDT). Efficacy of PDT in BD is supported by substantial research and clinical data.

Objectives: This study aimed to evaluate the long term effectiveness of methyl aminolevulinate-PDT (MAL/PDT) on a wide range of Bowen lesions in different locations and sizes. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.04.011DOI Listing

Diagnosis of Rhinocerebral Mucormycosis by Treatment of Cavernous Right Internal Carotid Artery Occlusion With Mechanical Thrombectomy: Special Case Presentation and Literature Review.

Front Neurol 2019 26;10:264. Epub 2019 Mar 26.

Department of Neurosurgery, Arrowhead Regional Medical Center, Colton, CA, United States.

Mucormycosis is a rapidly progressive, angioinvasive fungal infection that has a predilection for the paranasal sinuses and adjacent mucosa. Rhinocerebral mucormycosis (RCM) is the most common form and is known to invade the skull base and its associated blood vessels-leading to mycotic aneurysms, ischemic infarcts, and intracerebral hemorrhage. There are documented cases of mechanical thrombectomy in ischemic stroke due to RCM, however, there are no known cases that were diagnosed primarily by histological and pathological analysis of the embolus. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00264
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http://dx.doi.org/10.3389/fneur.2019.00264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443639PMC
March 2019
3 Reads

Combined the simple shaving with photodynamic therapy for refractory Bowen disease.

Photodiagnosis Photodyn Ther 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Xiangya <-- -->Hospital, Central South University, 87, Xiangya Road, Changsha, 41008, Hunan, China. Electronic address:

Bowen Disease (BD), also known as squamous cell carcinoma in situ, requires actively treatments. Photodynamic therapy (PDT) has been widely recommended to treat for BD. However, there are still a few BD patients with poor efficacy and recurrence after PDT treatment. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.04.001DOI Listing

Non-invasive imaging techniques for the diagnosis of Bowen's disease: Three case reports.

Oncol Lett 2019 May 27;17(5):4094-4101. Epub 2019 Feb 27.

Department of Dermatology, 'Prof. N. Paulescu' National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania.

Bowen's disease (BD) is a relatively frequent non-melanoma skin cancer occurring mostly in elderly people. Until now, the usual way to establish the diagnosis is histopathological examination of a skin biopsy. Dermoscopy and reflectance confocal microscopy (RCM) are modern alternative methods that can be used as quick and non-invasive diagnostic techniques and as follow-up instruments in cases in which a conservative treatment is chosen for the management of BD. Read More

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http://dx.doi.org/10.3892/ol.2019.10079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444281PMC
May 2019
4 Reads
0.987 Impact Factor

Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study.

Dermatology 2019 Apr 2:1-6. Epub 2019 Apr 2.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland,

Background: Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge.

Objective: To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors.

Methods: Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Read More

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http://dx.doi.org/10.1159/000496539DOI Listing
April 2019
4 Reads

Nail Squamous Cell Carcinoma: A Hidden High-risk HPV Reservoir for Sexually Transmitted Infections.

J Am Acad Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Human papillomavirus (HPV) causes cervical cancer, anal cancer, vulvar cancer, vaginal cancer, penile cancer and oropharyngeal cancer. SCC in the genital region in particular is recognized to be caused by HPV infection, and intraepithelial lesions of the penis and vulva are termed penile intraepithelial neoplasia (PIN) and vulvar intraepithelial neoplasia (VIN), respectively. Although SCC of the nail apparatus is recognized as being associated with high-risk HPVs, it is not well-known in general medicine, and its analysis has been insufficient. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.070DOI Listing
March 2019
2 Reads

Transcriptional Analysis of the Human IgE-Expressing Plasma Cell Differentiation Pathway.

Front Immunol 2019 11;10:402. Epub 2019 Mar 11.

Asthma UK Centre, Allergic Mechanisms in Asthma, King's College London, London, United Kingdom.

IgE is secreted by plasma cells (PCs) and is central to allergic disease. Using an tonsil B cell culture system, which mimics the Th2 responses , we have recently characterized the development pathway of human IgE-expressing PCs. In this system, as in mice, we reported the predisposition of IgE-expressing B cells to differentiate into PCs. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421273PMC
March 2019
1 Read

Pregnancy outcomes in women with cardiovascular disease: evolving trends over 10 years in the ESC Registry Of Pregnancy And Cardiac disease (ROPAC).

Eur Heart J 2019 Mar 25. Epub 2019 Mar 25.

Department of Cardiology, University of East Anglia, Faculty of Medicine, Norwich Research Park, Norwich, UK.

Aims: Reducing maternal mortality is a World Health Organization (WHO) global health goal. Although maternal deaths due to haemorrhage and infection are declining, those related to heart disease are increasing and are now the most important cause in western countries. The aim is to define contemporary diagnosis-specific outcomes in pregnant women with heart disease. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz136DOI Listing
March 2019
9 Reads

Burden of skin disease in two remote primary healthcare centres in northern and central Australia.

Intern Med J 2019 Mar;49(3):396-399

Menzies School of Health Research, Darwin, Northern Territory, Australia.

The burden of skin infections across all age groups in remote Australian Indigenous communities is currently unknown. In a retrospective audit of 439 residents from two remote communities presenting to health clinics, skin conditions were the most common reason for presentation (1603/7392, 22%) and 330/439 (75%) residents presented at least once with a skin infection. Skin infections are an under-appreciated and dominant reason for presentation to primary healthcare centres in these indigenous communities and public health campaigns to address this should incorporate all age groups. Read More

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http://dx.doi.org/10.1111/imj.14222DOI Listing
March 2019
1 Read

Cutaneous Bowen's Disease: an Analysis of 182 Cases according To Age, Sex, and Anatomical Site from an Italian Center.

Open Access Maced J Med Sci 2019 Feb 20;7(4):696-697. Epub 2019 Feb 20.

Department of Dermatology, University of Naples Federico II, Naples, Italy.

Bowen's disease (BD), also known as squamous cell carcinoma in situ, is a type of non-melanocytic intraepidermal malignancy characterised by a slowly enlarging erythematous to pink, scaly patch or plaque with irregular and well-demarcated borders. These lesions are usually persistent and progressive; it has been estimated that in general population around 3% to 5% of Bowen's disease transform into invasive squamous cell carcinoma. This report describes our experience with cutaneous BD and assesses the differences found about age, sex and anatomical site. Read More

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http://dx.doi.org/10.3889/oamjms.2019.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420931PMC
February 2019

Giant Bowen's Disease on the Face: Case Report and Review of the Literature.

Open Access Maced J Med Sci 2019 Feb 22;7(4):606-609. Epub 2019 Feb 22.

University Clinic of Dermatology, Ss. Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Giant Bowen's disease is a rare and unusual clinical manifestation. Presenting as extensive scaly erythematous patch or plaque, it gives rise to a wide spectrum of dermatological differential diagnoses.

Case Presentation: We report a patient with giant Bowen's disease on the face that was successfully treated with topical 5 % imiquimod. Read More

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http://dx.doi.org/10.3889/oamjms.2019.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420943PMC
February 2019
2 Reads

Complex immune responses and molecular reactions to pathogens and disease in a desert reptile ().

Ecol Evol 2019 Mar 18;9(5):2516-2534. Epub 2019 Feb 18.

Department of Biology Pennsylvania State University University Park Pennsylvania.

Immune function plays an important role in an animal's defense against infectious disease. In reptiles, immune responses may be complex and counterintuitive, and diagnostic tools used to identify infection, such as induced antibody responses are limited. Recent studies using gene transcription profiling in tortoises have proven useful in identifying immune responses to various intrinsic and extrinsic stressors. Read More

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http://doi.wiley.com/10.1002/ece3.4897
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http://dx.doi.org/10.1002/ece3.4897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405529PMC
March 2019
4 Reads

Identifying the unmet information and support needs of women with autoimmune rheumatic diseases during pregnancy planning, pregnancy and early parenting: mixed-methods study.

BMC Rheumatol 2018 27;2:21. Epub 2018 Jul 27.

1Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK.

Background: Autoimmune rheumatic diseases (ARDs) such as inflammatory arthritis and Lupus, and many of the treatments for these diseases, can have a detrimental impact on fertility and pregnancy outcomes. Disease activity and organ damage as a result of ARDs can affect maternal and foetal outcomes. The safety and acceptability of hormonal contraceptives can also be affected. Read More

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https://bmcrheumatol.biomedcentral.com/articles/10.1186/s419
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http://dx.doi.org/10.1186/s41927-018-0029-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390539PMC
July 2018
2 Reads

Dementia worry in middle-aged and older adults in Germany: sociodemographic, health-related and psychological correlates.

Eur J Ageing 2019 Mar 28;16(1):39-52. Epub 2018 Feb 28.

2Zentrum für Kinder-und Jugendmedizin, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany.

"Dementia worry" (DW; i.e., concern about developing dementia) is highly prevalent in the general population. Read More

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http://dx.doi.org/10.1007/s10433-018-0462-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397106PMC

Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

Department of Dermatology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, 67100 L'Aquila, Italy.

The role of telomere biology and telomerase activation in skin cancers has been investigated in melanoma and basal cell carcinoma but limited evidence is available for cutaneous squamous cell carcinoma (cSCC). We will review the current knowledge on the role of telomere and telomerase pathway in cSCC pathogenesis. At the somatic level, both long and short telomere lengths have been described in cSCC. Read More

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http://dx.doi.org/10.3390/ijms20061333DOI Listing
March 2019
1 Read

Rapidly Progressive Intracranial Vasculopathy in Graft Versus Host Disease.

J Stroke Cerebrovasc Dis 2019 Mar 13. Epub 2019 Mar 13.

Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

After allogenic hematopoietic stem cell transplantation, cerebrovascular complications are uncommon, occurring in approximately 2%, and typically due to coagulopathy or infection. Graft versus host disease has been rarely reported to affect the central nervous system but these cases typically describe leukoencephalopathy, encephalitis, or perivascular infiltrates or vasculitis with subcortical ischemia or hemorrhage. We report a previously undescribed noninflammatory vasculopathy causing multifocal intracranial arterial occlusions and cerebral infarctions in a man following allogenic hematopoietic stem cell transplantation for chronic lymphocytic leukemia, which we propose to be a central nervous system manifestation of graft versus host disease. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.017DOI Listing
March 2019
1 Read

Successful Treatment for Extensive Bowen's Disease using Daylight-mediated Photodynamic Therapy.

Acta Derm Venereol 2019 Mar 14. Epub 2019 Mar 14.

Department of Dermatology, CHRU Tours, FR-37044 Tours Cedex 9, France.

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http://dx.doi.org/10.2340/00015555-3174DOI Listing
March 2019
3.025 Impact Factor

Ki-67 and p16 Immunostaining Differentiates Pagetoid Bowen Disease From "Microclonal" Seborrheic Keratosis.

Am J Clin Pathol 2019 Mar 10. Epub 2019 Mar 10.

Department of Dermatology and University of California, San Francisco.

Objectives: We observed keratoses with "clonal" nests present as numerous tiny collections, in which cells in "pagetoid" array are found, a configuration we termed microclonal seborrheic keratosis (MSK). To better distinguish MSK from pagetoid Bowen disease (PBD), we investigated use of immunohistochemical staining.

Methods: Biopsy specimens of 26 MSKs, 17 PBDs, and 11 borderline cases were reviewed for histopathology and stained with p53, Ki-67, and p16. Read More

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http://dx.doi.org/10.1093/ajcp/aqz001DOI Listing
March 2019
1 Read

Distribution of high-risk α-genus human papillomavirus genotypes impacts cutaneous neoplasms.

J Eur Acad Dermatol Venereol 2019 Mar 5. Epub 2019 Mar 5.

Department of Dermatology and Allergology, University Hospital of Munich LMU, Munich, Germany.

Background: High-risk α-genus human papillomaviruses (α-HPVs) are linked to cervical and genital carcinomas; however, their correlation with cutaneous squamous cell carcinoma (cuSCC) or premalignant skin lesions remains controversial.

Objective: We evaluated the contribution of high-risk α-HPV to the occurrence of cuSCC, Bowen's disease and actinic keratosis (AK), and the distribution of high-risk α-HPV genotypes in these cutaneous tumours.

Methods: HPV genotypes were determined using a commercial PCR-based microarray on skin tissue samples collected from 76 [38 young (<60 years) and 38 elderly (>60 years)] cuSCC, 34 Bowen's disease, 48 AK patients and 10 young controls. Read More

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http://dx.doi.org/10.1111/jdv.15547DOI Listing
March 2019
4 Reads

Efficacy of an Adjuvanted Middle East Respiratory Syndrome Coronavirus Spike Protein Vaccine in Dromedary Camels and Alpacas.

Viruses 2019 Mar 2;11(3). Epub 2019 Mar 2.

Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80521, USA.

MERS-CoV is present in dromedary camels throughout the Middle East and Africa. Dromedary camels are the primary zoonotic reservoir for human infections. Interruption of the zoonotic transmission chain from camels to humans, therefore, may be an effective strategy to control the ongoing MERS-CoV outbreak. Read More

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http://dx.doi.org/10.3390/v11030212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466352PMC
March 2019
3.279 Impact Factor

Clonal highlights: Clonal seborrheic keratoses often demonstrates p16 expression.

J Cutan Pathol 2019 Mar 3. Epub 2019 Mar 3.

Department of Pathology, Loyola University Medical Center, Maywood, Illinois.

Background: At times, distinguishing Bowen disease (BD) and benign seborrheic keratosis (SK) is histologically challenging, especially when SK shows clonal features (clonal seborrheic keratosis [CSK]). While p16 is often reported as positive in BD and negative in SK, p16 expression in CSK is rarely studied. Here we investigate p16 immunohistochemistry in CSK, SK, and BD. Read More

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http://dx.doi.org/10.1111/cup.13449DOI Listing
March 2019
1 Read

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gena Roschupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Read More

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019
15 Reads
29.352 Impact Factor

Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population.

mSphere 2019 02 27;4(1). Epub 2019 Feb 27.

Department of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences, Pennsylvania State University, State College, Pennsylvania, USA

More than 14,000 neonates are infected with herpes simplex virus (HSV) annually. Approximately half display manifestations limited to the skin, eyes, or mouth (SEM disease). The rest develop invasive infections that spread to the central nervous system (CNS disease or encephalitis) or throughout the infected neonate (disseminated disease). Read More

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http://dx.doi.org/10.1128/mSphere.00590-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393728PMC
February 2019
3 Reads

Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure.

PLoS Negl Trop Dis 2019 02 27;13(2):e0006851. Epub 2019 Feb 27.

The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, United States of America.

Burkholderia pseudomallei causes melioidosis, a common source of pneumonia and sepsis in Southeast Asia and Northern Australia that results in high mortality rates. A caprine melioidosis model of aerosol infection that leads to a systemic infection has the potential to characterize the humoral immune response. This could help identify immunogenic proteins for new diagnostics and vaccine candidates. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411198PMC
February 2019

Misoprostol is superior to combined omeprazole-sucralfate for the treatment of equine gastric glandular disease.

Equine Vet J 2019 Feb 26. Epub 2019 Feb 26.

School of Veterinary Medicine and Science, University of Nottingham, Loughborough, UK.

Background: Previous studies have demonstrated a poor response to healing of gastric glandular lesions with oral omeprazole and other medications.

Objectives: To evaluate the efficacy of two novel treatments (misoprostol [M] and combined omeprazole-sucralfate [OS]) in horses for gastric glandular disease.

Study Design: Prospective, clinical study. Read More

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http://dx.doi.org/10.1111/evj.13087DOI Listing
February 2019
1 Read

In-transit recurrence of Merkel cell carcinoma associated with Bowen's disease: The first reported case successfully treated by avelumab.

J Dermatol 2019 Feb 27. Epub 2019 Feb 27.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

A 65-year-old Japanese man presented with a dome-shaped nodule, the base of which was contiguous with a dull brown plaque, on the left leg. After local excision of the cutaneous lesion and left inguinal lymph node dissection, several dermal and subcutaneous nodules developed successively on the left lower extremity. Hematoxylin-eosin staining of the primary cutaneous lesion demonstrated uniform neoplastic cells arranged in a trabecular pattern extending from the dermis to subcutis. Read More

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http://dx.doi.org/10.1111/1346-8138.14829DOI Listing
February 2019
2 Reads

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition.

Front Mol Biosci 2019 8;6. Epub 2019 Feb 8.

Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, United States.

The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid. Quinolinic acid (QUIN) is an excitotoxic agonist at the NMDA receptor, and has been shown to be elevated in neurodegenerative diseases such as Alzheimer's Disease and Huntington's Disease. Read More

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http://dx.doi.org/10.3389/fmolb.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376250PMC
February 2019

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults.

J Vis Exp 2019 Feb 8(144). Epub 2019 Feb 8.

Department of Kinesiology and Applied Physiology, University of Delaware.

A real-time locating system (RTLS) can be used to track the walking activity of institutionalized older adults in long-term care who are at risk for wandering behaviors. The benefits of a RTLS are objective and continuous measurements of activity. Self-report methods of activity, especially wandering, by health care staff are vulnerable to floor effects and recall bias, and continuous clinical or research observation over the long-term can be time-consuming and expensive. Read More

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http://dx.doi.org/10.3791/58834DOI Listing
February 2019

Autologous Hematopoietic Cell Transplantation for Treatment-Refractory Relapsing Multiple Sclerosis: Position Statement from the American Society for Blood and Marrow Transplantation.

Biol Blood Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Multiple sclerosis (MS) is a chronic, disabling, immune-mediated, demyelinating and degenerative disease of the central nervous system. Approved disease-modifying therapies may be incompletely effective in some patients with highly active relapsing disease and high risk of disability. The use of immunoablative or myeloablative therapy followed by autologous hematopoietic cell transplantation (AHCT) has been investigated in retrospective studies, clinical trials, and meta-analyses/systematic reviews as an approach to address this unmet clinical need. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10838791193013
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http://dx.doi.org/10.1016/j.bbmt.2019.02.014DOI Listing
February 2019
6 Reads

Acute Colitis Drives Tolerance by Persistently Altering the Epithelial Barrier and Innate and Adaptive Immunity.

Inflamm Bowel Dis 2019 Feb 22. Epub 2019 Feb 22.

Centre for Nutrition and Gastrointestinal Disease, Adelaide Medical School, University of Adelaide & South Australian Health and Medical Research Institute, Adelaide, Australia.

Background: Inflammatory bowel disease (IBD) has a remitting and relapsing disease course; however, relatively little is understood regarding how inflammatory damage in acute colitis influences the microbiota, epithelial barrier, and immune function in subsequent colitis.

Methods: Mice were administered trinitrobenzene sulphonic acid (TNBS) via enema, and inflammation was assessed 2 days (d2) or 28 days (d28) later. Colitis was reactivated in some mice by re-treating at 28 days with TNBS and assessing 2 days later (d30). Read More

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https://academic.oup.com/ibdjournal/advance-article/doi/10.1
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http://dx.doi.org/10.1093/ibd/izz011DOI Listing
February 2019
3 Reads

Comparing web-based video interventions to enhance university student willingness to donate organs: A randomized controlled trial.

Clin Transplant 2019 Apr 13;33(4):e13506. Epub 2019 Mar 13.

Center for Reducing Health Disparities, MetroHealth Campus of Case Western Reserve University, Cleveland, Ohio.

Background: The efficacy of video interventions to increase organ donation willingness remains unclear.

Methods: Three-arm web-based randomized controlled trial involving 2261 students at 3 northeastern Ohio universities. Intervention students watched a live-action (n = 755) or animated (n = 753) donation video. Read More

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http://dx.doi.org/10.1111/ctr.13506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474353PMC

Comparing provider and patient views of issues for low-resourced breast cancer patients.

Psychooncology 2019 Feb 20. Epub 2019 Feb 20.

Department of Bioethics and Humanities, University of Washington, Seattle, Washington.

Objective: The purpose of this study was to compare provider and patient views from the same clinical settings on issues raised by low-socioeconomic status (SES) breast cancer survivors.

Methods: We conducted qualitative interviews among two groups: low-SES breast cancer survivors (n = 37) and medical personnel (ie, physicians, nurses, and navigators; n = 8) who interact and serve with these patients from two geographically distinct low-resourced clinical settings. These semistructured qualitative interviews used grounded theory to identify several potential themes, such as finances, resources, and medical care. Read More

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http://dx.doi.org/10.1002/pon.5035DOI Listing
February 2019
2 Reads

Evaluation of the impact of shigellosis exclusion policies in childcare settings upon detection of a shigellosis outbreak.

BMC Infect Dis 2019 Feb 19;19(1):172. Epub 2019 Feb 19.

National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, H24-11, Atlanta, GA, 30329-4027, USA.

Background: In the event of a shigellosis outbreak in a childcare setting, exclusion policies are typically applied to afflicted children to limit shigellosis transmission. However, there is scarce evidence of their impact.

Methods: We evaluated five exclusion policies: Children return to childcare after: i) two consecutive laboratory tests (either PCR or culture) do not detect Shigella, ii) a single negative laboratory test (PCR or culture) does not detect Shigella, iii) seven days after beginning antimicrobial treatment, iv) after being symptom-free for 24 h, or v) 14 days after symptom onset. Read More

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http://dx.doi.org/10.1186/s12879-019-3796-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379933PMC
February 2019
2 Reads

Serum MicroRNAs as Biomarkers in Hepatitis C: Preliminary Evidence of a MicroRNA Panel for the Diagnosis of Hepatocellular Carcinoma.

Int J Mol Sci 2019 Feb 17;20(4). Epub 2019 Feb 17.

Hepatic Fibrosis Group, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, QLD 4006, Australia.

Early diagnosis of cirrhosis and hepatocellular carcinoma (HCC) due to chronic Hepatitis C (CHC) remain clinical priorities. In this pilot study, we assessed serum microRNA (miRNA) expression to distinguish cirrhosis and HCC, alone and in combination with the aminotransferase-to-platelet ratio (APRI), Fibrosis 4 (FIB-4), and alpha-fetoprotein (AFP). Sixty CHC patients were subdivided into 3 cohorts: Mild disease (fibrosis stage F0-2; = 20); cirrhosis ( = 20); and cirrhosis with HCC ( = 20). Read More

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http://dx.doi.org/10.3390/ijms20040864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412219PMC
February 2019
2.862 Impact Factor

Diets Enriched with Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet with a Western Fatty Acid Profile in Adults with Central Adiposity.

J Nutr 2019 Mar;149(3):471-478

Departments of Food and Human Nutritional Sciences, Winnipeg, MB, Canada.

Background: Novel oils high in monounsaturated fatty acids (MUFAs) and low in saturated fatty acids (SFAs) are an alternative to partially hydrogenated oils high in trans-unsaturated fatty acids. There is widespread use of high-MUFA oils across the food industry; however, limited knowledge of their cardiovascular impact exists.

Objectives: We investigated the effects of diets containing canola oil, high-oleic acid canola oil (HOCO), and a control oil blend (diet formulated to emulate a Western fat profile) on lipids, lipoproteins, and apolipoproteins (apos), as secondary outcomes of the trial. Read More

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http://dx.doi.org/10.1093/jn/nxy307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398388PMC
March 2019
3 Reads

Relationship between dermoscopy and pathology in a case of clonal-type pigmented Bowen's disease: Observation with vertical-view dermoscopy.

J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Osaka Police Hospital, Osaka, Japan.

Pigmented Bowen's disease (pBD) is a subtype of Bowen's disease, which presents clinically as a well-circumscribed, hyperpigmented plaque. Its clinical manifestations are not fully characterized, and differential diagnoses include various pigmented skin lesions. Dermoscopy could be useful for the diagnosis, although nothing has been reported on the dermoscopic features of clonal-type pBD. Read More

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http://dx.doi.org/10.1111/1346-8138.14814DOI Listing
February 2019
1 Read

Current status and future recommendations for feral swine disease surveillance in the United States.

J Anim Sci 2019 Feb 5. Epub 2019 Feb 5.

Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

USDA APHIS Wildlife Services (WS) responded to the recognized threat of feral swine as a pathogen reservoir as early as 2004 through opportunistic sampling of animals harvested by its operational component to curtail swine damage to agriculture and property. Initially, pseudorabies and swine brucellosis were of most concern, as both serve as a potential threat to the domestic swine industry and the latter also possesses zoonotic implications. In 2006, classical swine fever, a foreign animal disease (FAD), became the main driver for feral swine pathogen surveillance. Read More

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http://dx.doi.org/10.1093/jas/skz054DOI Listing
February 2019
5 Reads

Comparison of Herpes Simplex Virus 1 Strains Circulating in Finland Demonstrates the Uncoupling of Whole-Genome Relatedness and Phenotypic Outcomes of Viral Infection.

J Virol 2019 Apr 3;93(8). Epub 2019 Apr 3.

Department of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, USA

A majority of adults in Finland are seropositive carriers of herpes simplex viruses (HSV). Infection occurs at epithelial or mucosal surfaces, after which virions enter innervating nerve endings, eventually establishing lifelong infection in neurons of the sensory or autonomic nervous system. Recent data have highlighted the genetic diversity of HSV-1 strains and demonstrated apparent geographic patterns in strain similarity. Read More

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http://dx.doi.org/10.1128/JVI.01824-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450105PMC

Evidence for Household Transmission of Rotavirus in the United States, 2011-2016.

J Pediatric Infect Dis Soc 2019 Feb 7. Epub 2019 Feb 7.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Rotavirus is a leading cause of acute gastroenteritis (AGE) in children and is highly transmissible. In this study, we assessed the presence of AGE in household contacts (HHCs) of pediatric patients with laboratory-confirmed rotavirus.

Methods: Between December 2011 and June 2016, children aged 14 days to 11 years with AGE were enrolled at 1 of 7 hospitals or emergency departments as part of the New Vaccine Surveillance Network. Read More

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https://academic.oup.com/jpids/advance-article/doi/10.1093/j
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http://dx.doi.org/10.1093/jpids/piz004DOI Listing
February 2019
9 Reads

Development of FamilyTalk: an Intervention to Support Communication and Educate Families About Colorectal Cancer Risk.

J Cancer Educ 2019 Feb 9. Epub 2019 Feb 9.

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.

IFamily members of individuals with colorectal cancer (CRC) may be at increased risk of developing the disease. However, the majority of CRC can be prevented through colonoscopy screening and family members may not be aware if they are recommended to pursue earlier screening because of their family history of CRC. As such, tools must be developed to effectively communicate potential changes to the recommended age for colonoscopy screening and other important CRC-related information to family members. Read More

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http://dx.doi.org/10.1007/s13187-019-1484-3DOI Listing
February 2019
2 Reads

Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model.

Chemotherapy 2018 7;63(5):284-292. Epub 2019 Feb 7.

Discipline of Physiology, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Background: The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered efforts to deliver effective supportive care interventions, particularly for gastrointestinal (GI) toxicity. Matrix metalloproteinases (MMPs) have been implicated in both tumor growth and GI toxicity, and as such MMP inhibitors present as a novel therapeutic avenue to simultaneously enhance treatment efficacy and reduce toxicity.

Objectives: The aim of this study was to determine the efficacy of an MMP-9/12 inhibitor, AZD3342, on tumor growth and GI toxicity in a rat model. Read More

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http://dx.doi.org/10.1159/000495470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425820PMC
March 2019
1 Read

Bowen disease with invasive mucin-secreting sweat gland differentiation: Report of a case and review of the literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Central Zone (Halifax), Halifax, Nova Scotia, Canada.

Bowen disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically, these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. Read More

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http://dx.doi.org/10.1111/cup.13437DOI Listing
February 2019
3 Reads

The causes of nail apparatus pigmentation presenting to a melanoma screening clinic a prospective study.

Clin Exp Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Dermatology Unit, Royal Victoria Infirmary, Newcastle Upon Tyne, UK.

Background: Advanced stage primary cutaneous malignant melanoma (PCMM) has a high mortality. PCMM may affect any area of the skin, including the nail apparatus (malignant melanoma or subungual melanoma). Although nail apparatus malignant melanoma (NAMM) is rare, delayed diagnosis carries a poor prognosis. Read More

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http://doi.wiley.com/10.1111/ced.13897
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http://dx.doi.org/10.1111/ced.13897DOI Listing
January 2019
8 Reads

Long-term efficacy of photodynamic therapy with methyl aminolevulinate in treating Bowen's disease in clinical practice: A retrospective cohort study (2006-2017).

Photodermatol Photoimmunol Photomed 2019 Jan 28. Epub 2019 Jan 28.

Departments of Dermatology, Hospital Costa del Sol, Marbella, Spain.

Background: Photodynamic treatment with methyl aminolevulinate (MAL-PDT) is considered an effective and highly recommended treatment for Bowen's disease. However, its long-term efficacy remains to be established, as significant differences have been reported in this respect.

Objective: The aim of the present study was to describe the results of a retrospective analysis of patients with Bowen's disease treated with MAL-PDT during the period 2006-17 at the Costa del Sol Hospital (Marbella, Spain). Read More

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http://dx.doi.org/10.1111/phpp.12453DOI Listing
January 2019