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    Lichenoid keratosis is frequently misdiagnosed as basal cell carcinoma.
    Clin Exp Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Dermatology, Sir Charles Gairdner Hospital, Nedlands, Perth, WA, Australia.
    Lichenoid keratosis (LK), also known as benign lichenoid keratosis or lichen planus-like keratosis, is a solitary, pink to red-brown scaly plaque representing a host immunological response to a variety of precursor lesions. LK is often misdiagnosed as a dermatological malignancy owing to its clinical resemblance to basal cell carcinoma (BCC) or Bowen disease. We performed a retrospective analysis of the pathology records of a series of LK lesions with reference to the demographic features and accuracy of clinical diagnosis. Read More

    Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study.
    Alzheimers Dement 2017 Jun 14. Epub 2017 Jun 14.
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
    Introduction: There may be biologically relevant heterogeneity within typical late-onset Alzheimer's dementia.

    Methods: We analyzed cognitive data from people with incident late-onset Alzheimer's dementia from a prospective cohort study. We determined individual averages across memory, visuospatial functioning, language, and executive functioning. Read More

    Retrospective evaluation of exposure to natural UV radiation: experiences with the online UV history tool in a field study.
    J Dtsch Dermatol Ges 2017 Jun;15(6):610-619
    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine at the University of Erlangen-Nuremberg (FAU), Erlangen, Germany.
    Background: Cutaneous squamous cell carcinoma and multiple actinic keratoses can be recognized as occupational diseases if the site affected has been subjected to additional occupational UV exposure of at least 40 %. An online UV history tool that allows for the quantification of occupational and recreational UV doses was now tested in a field study.

    Patients And Methods: Ninety-nine patients with nonmelanoma skin cancer were examined. Read More

    Assessment of functional liver reserve: old and new in 99mTc-sulfur colloid scintigraphy.
    Nucl Med Commun 2017 Jul;38(7):577-586
    aDepartment of Radiology, School of Medicine, Division of Nuclear Medicine bDepartment of Radiation Oncology, School of Medicine, University of Washington, Seattle, Washington, USA.
    Purpose: A semiquantitative assessment of hepatic reticuloendothelial system function using colloidal particles scintigraphy has been proposed previously as a surrogate for liver function evaluation. In this article, we present an updated method for the overall assessment of technetium-99m (Tc)-sulfur colloid (SC) biodistribution that combines information from planar and attenuation-corrected Tc-SC single-photon emission computed tomography (SPECT) images. The imaging protocol described here was developed as an easy-to-implement method to assess overall and regional liver function changes associated with chronic liver disease. Read More

    Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease.
    PLoS One 2017 5;12(6):e0178987. Epub 2017 Jun 5.
    Department of Molecular Hepatology, Centenary Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
    Background And Aim: Circulating fibroblast activation protein (cFAP) is a constitutively active enzyme expressed by activated fibroblasts that has both dipeptidyl peptidase and endopeptidase activities. We aimed to assess the correlation between cFAP activity and antigen levels and to compare variations in levels.

    Methods: In plasma of 465 control individuals, 368 patients with coronary heart disease (CHD) and 102 hepatitis C virus (HCV) infected patients with severe liver disease before and after liver transplant, cFAP activity levels were measured with a newly developed cFAP activity assay. Read More

    Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy.
    N Engl J Med 2017 Jun 3. Epub 2017 Jun 3.
    From the Institute of Cancer and Genomic Sciences, University of Birmingham (N.D.J.), and University Hospital Birmingham (A.Z.), Birmingham, the Institute of Cancer Research (J.S.B., D.P.D., G.A.), Medical Research Council Clinical Trials Unit at University College London (M.R. Spears, C.L.A., C.G., C.B., M.K.B.P., M.R. Sydes), King's College London and Guy's and St. Thomas' NHS Foundation Trust (S.C.), and Royal Marsden NHS Foundation Trust (C.C.P.), London, Salford Royal NHS Foundation Trust, Salford (N.W.C.), Cardiff University School of Medicine (M.D.M.) and Velindre Cancer Centre (J.F.L.), Cardiff, Gloucestershire Royal Hospital (A.W.S.R.) and Gloucestershire Hospitals NHS Foundation Trust (J.B.), Gloucester, University of Glasgow, Glasgow (R.J.J., J.M.R.), St. James's University Hospital, Leeds (W.R.C.), University Hospital of North-Midlands, Stoke-on-Trent (F.A.), Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter (S.A.), Rosemere Cancer Centre, Royal Preston Hospital, Preston (A.J.B.), Dorset Cancer Centre, Poole Hospital, Poole (S.B.), Royal Derby Hospital, Derby (P.C.), Weston Park Hospital, Sheffield (C.F.), Portsmouth Oncology Centre, Queen Alexandra Hospital, Portsmouth (J.G.), Musgrove Park Hospital, Taunton (E.G.), Hull and East Yorkshire Hospitals NHS Trust, Hull (M.H.), Mount Vernon Cancer Centre, Northwood (P.J.H.), Clatterbridge Cancer Centre, Wirral (Z.I.M.), Brighton and Sussex University Hospitals NHS Trust (F.M.) and Sussex Cancer Centre, Royal Sussex County Hospital (A.R.), Brighton, NHS Highland, Inverness (N.M.), Royal Surrey County Hospital, Guildford (J.M.-K.), Northern Ireland Cancer and Queens University, Belfast (J.O.), Lancashire Teaching Hospitals NHS Trust, Preston (O.P.), Churchill Hospital, Oxford (A.P.), Shrewsbury and Telford Hospitals NHS Trust, Shrewsbury (N.N.S.), East Kent Hospitals NHS Trust, Canterbury (C.T.), Swansea University College of Medicine, Swansea (J. Wagstaff), and Christie NHS Foundation Trust, Manchester (J. Wylie) - all in the United Kingdom; and the Department of Medical Oncology, Kantonsspital St. Gallen, St. Gallen (S.G.), and University Hospital of Lausanne, Lausanne (D.R.B.) - both in Switzerland. Two of the authors (D.M., R.M.) were unaffiliated lay members of the STAMPEDE investigators.
    Background Abiraterone acetate plus prednisolone improves survival in men with relapsed prostate cancer. We assessed the effect of this combination in men starting long-term androgen-deprivation therapy (ADT), using a multigroup, multistage trial design. Methods We randomly assigned patients in a 1:1 ratio to receive ADT alone or ADT plus abiraterone acetate (1000 mg daily) and prednisolone (5 mg daily) (combination therapy). Read More

    mHealth App for Risk Assessment of Pigmented and Nonpigmented Skin Lesions-A Study on Sensitivity and Specificity in Detecting Malignancy.
    Telemed J E Health 2017 May 31. Epub 2017 May 31.
    6 Department of Dermatology and Allergology, Ludwig-Maximilian University , Munich, Germany .
    Background: With the advent of smartphone devices, an increasing number of mHealth applications that target melanoma identification have been developed, but none addresses the general context of melanoma and nonmelanoma skin cancer identification.

    Introduction: In this study a smartphone application using fractal and classical image analysis for the risk assessment of skin lesions is systematically evaluated to determine its sensitivity and specificity in the diagnosis of melanoma and nonmelanoma skin cancer along with actinic keratosis and Bowen's disease.

    Materials And Methods: In the Department of Dermatology, Catharina Hospital Eindhoven, The Netherlands, 341 melanocytic and nonmelanocytic lesions were imaged using SkinVision app; 239 underwent histopathological examination, while the rest of 102 lesions were clinically diagnosed as clearly benign and not removed. Read More

    The immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection.
    BMC Immunol 2017 May 19;18(1):27. Epub 2017 May 19.
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Drive S.W., Atlanta, GA, 30310, USA.
    Background: We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the molecular and biochemical mechanism underlying the superior immunostimulatory property of IL-10 deficient DCs we performed proteomic analysis on protein profiles from Chlamydia-pulsed wild-type (WT) and IL-10(-/-) DCs to identify differentially expressed proteins with immunomodulatory properties.

    Results: The results showed that alpha enolase (ENO1), a metabolic enzyme involved in the last step of glycolysis was significantly upregulated in Chlamydia-pulsed IL-10(-/-) DCs compared to WT DCs. Read More

    Diagnostic Criteria in Intraepithelial Pagetoid Neoplasms: A Histopathologic Study and Evaluation of Select Features in Paget Disease, Bowen Disease, and Melanoma In Situ.
    Am J Dermatopathol 2017 Jun;39(6):419-427
    *Demonstrator at the Dermatology Department, Kasralainy Faculty of Medicine, Cairo, University, Egypt; †Visiting Research Fellow, Ackerman Academy of Dermatopathology, New York, NY; ‡Attending Dermatologist, Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangdong Provincial Dermatology Hospital, China; §Junior Specialist, Department of Dermatology, University of California, Irvine, CA; ¶Attending Dermatologist, Department of Dermatology, Jose R. Reyes Memorial Medical Center, Manila; ‖Medical Student, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ; #Professor of Biostatistics, Department of Biostatistics and Epidemiology, National Cancer Institute, Cairo University, Cairo, Egypt; **Dermatopathologist, Dermpath Diagnostics New York, Port Chester, NY; and ††Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC.
    Background: Paget disease, Bowen disease, and malignant melanoma in situ are intraepidermal neoplasms, characterized by the presence of pagetoid scatter of atypical cells in the epidermis. This study reviewed the frequency of select histologic criteria to validate their usefulness in the histologic distinction between these entities.

    Methods: One hundred forty-four specimens with the diagnosis of Bowen disease, 144 specimens with Paget disease (mammary and extramammary), and 144 specimens with malignant melanoma in situ were examined microscopically to define frequencies of select histologic criteria present in each disease. Read More

    Clinical, histological and therapeutic features of Bowen's disease.
    Rom J Morphol Embryol 2017 ;58(1):33-40
    Department of Plastic Surgery and Reconstructive Microsurgery, Emergency Clinical Hospital of Bucharest, Romania;
    Squamous cell carcinoma (SCC) in situ or Bowen's disease (BD) is a slowly progressive malignancy. However, cases of regression have been reported. Recent reviews cover only certain aspects of this disease; therefore, this paper's aim is to cover all the relevant aspects for medical practice, such as clinical, histological and therapeutic details. Read More

    Comparison of the incidence of skin cancers in patients on dialysis and after kidney transplantation.
    Postepy Dermatol Alergol 2017 Apr 13;34(2):138-142. Epub 2017 Apr 13.
    Department of Nephrology, Jagiellonian University Medical College, Krakow, Poland.
    Introduction: Kidney transplant (KTx) patients on immunosuppressive therapy are predisposed to the development of infections and cancers.

    Aim: To compare the incidence and type of malignant skin lesions in kidney transplant patients and the dialyzed population based on the initiated dermatologic screening.

    Material And Methods: The study included 598 patients: 486 kidney transplant recipients and 112 patients on maintenance dialysis. Read More

    Increased Risk for Meningococcal Disease among Men who have Sex with Men in the United States, 2012-2015.
    Clin Infect Dis 2017 May 13. Epub 2017 May 13.
    Centers for Disease Control and Prevention.
    Background: Several clusters of serogroup C meningococcal disease among men who have sex with men (MSM) have been reported in the United States in recent years. The epidemiology and risk of meningococcal disease among MSM is not well-described.

    Methods: All meningococcal disease cases among men aged 18-64 years reported to the National Notifiable Disease Surveillance System between January 2012 and June 2015 were reviewed. Read More

    In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using dynamic optical coherence tomography.
    J Eur Acad Dermatol Venereol 2017 May 14. Epub 2017 May 14.
    CMB/Collegium Medicum Berlin, Berlin, Germany.
    Background: A clear distinction between actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC) cannot reliably be made by clinical and dermoscopic evaluation alone. Dynamic optical coherence tomography (D-OCT) is a novel angiographic variant of OCT that allows for non-invasive, in vivo evaluation of the cutaneous microvascular morphology.

    Objective: To investigate the microvascular structures of AK, BD and invasive SCC using D-OCT in order to gain insights into the microvascular morphology of lesions in the spectrum of keratinocyte skin cancers. Read More

    Expression of PD-L1 in keratoacanthoma and different stages of progression in cutaneous squamous cell carcinoma.
    Cancer Immunol Immunother 2017 May 13. Epub 2017 May 13.
    Skin Cancer Center of the Department of Dermatology, St. Josef Hospital, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.
    Background: Programmed cell death 1 (PD-1) and its ligands (PD-L1) play a major role in the immune responses of a variety of cancers.

    Objectives: To investigate the expression of PD-L1 in different progression forms of cutaneous squamous cell carcinoma (cSCC) and keratoacanthoma (KA).

    Methods: We performed immunohistochemical staining of 21 KA, 26 actinic keratoses (AK), 20 Bowen´s diseases (BD), and 26 high-risk cSCC. Read More

    miR-21 Promotes Fibrogenesis in Peritoneal Dialysis.
    Am J Pathol 2017 Jul 9;187(7):1537-1550. Epub 2017 May 9.
    Wales Kidney Research Unit, Division of Infection and Immunity, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom. Electronic address:
    Peritoneal dialysis (PD) is a life-saving form of renal replacement therapy for those with end-stage kidney disease. Mesothelial cells (MCs) line the peritoneal cavity and help define peritoneal response to treatment-associated injury, a major reason for treatment failure. miRNAs are important regulators, but their roles in peritoneal fibrosis are largely unknown. Read More

    Selumetinib Plus Docetaxel Compared With Docetaxel Alone and Progression-Free Survival in Patients With KRAS-Mutant Advanced Non-Small Cell Lung Cancer: The SELECT-1 Randomized Clinical Trial.
    JAMA 2017 05;317(18):1844-1853
    Respiratory Oncology Unit, Department of Respiratory Diseases, University Hospital Katholieke Universiteit Leuven, Leuven, Belgium.
    Importance: There are no specifically approved targeted therapies for the most common genomically defined subset of non-small cell lung cancer (NSCLC), KRAS-mutant lung cancer.

    Objective: To compare efficacy of the mitogen-activated protein kinase kinase (MEK) inhibitor selumetinib + docetaxel with docetaxel alone as a second-line therapy for advanced KRAS-mutant NSCLC.

    Design, Setting, And Participants: Multinational, randomized clinical trial conducted at 202 sites across 25 countries from October 2013 through January 2016. Read More

    Patients with non-viral liver disease have a greater tumor burden and less curative treatment options when diagnosed with hepatocellular carcinoma.
    World J Gastroenterol 2017 Apr;23(15):2763-2770
    Waled Mohsen, Marcia Rodov, Emilia Prakoso, Barbara Charlton, David G Bowen, David J Koorey, Nicholas A Shackel, Geoffrey W McCaughan, Simone I Strasser, AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney NSW 2050, Australia.
    Aim: To assess the impact of underlying liver disease etiology on the presenting features and outcomes in a large cohort of patients with hepatocellular carcinoma (HCC).

    Methods: A prospective database of all patients with HCC was established from 1998 to March 2012. One thousand and seventy-eight patients were categorized into three groups, based on the etiology of their liver disease: hepatitis B virus (HBV), hepatitis C virus (HCV) and non-viral liver disease (NVLD). Read More

    Clonal Seborrheic Keratosis Versus Pagetoid Bowen Disease: Histopathology and Role of Adjunctive Markers.
    Am J Dermatopathol 2017 Jun;39(6):433-439
    *Department of Pathology, St. John's Medical College, Bengaluru, India; and †Department of Dermatopathology, Dermatologikum Hamburg, Hamburg, Germany.
    Clonal seborrheic keratosis (CSK) and pagetoid Bowen disease (squamous cell carcinoma in situ) (PBD) share similar histological features making it sometimes difficult to differentiate the 2. The study group included 29 and 13 cases of CSK and PBD, respectively. Both groups were examined histopathologically (suprabasal mitotic figures, broad rete ridges, crowding of nuclei, nuclear pleomorphism, necrotic keratinocytes, parakeratosis, and dermal inflammation) and immunohistochemically (CK10, Ki-67, and p16). Read More

    Pathogen-Specific Burden of Outpatient Diarrhea in Infants in Nepal: A Multisite Prospective Case-Control Study.
    J Pediatric Infect Dis Soc 2017 May 4. Epub 2017 May 4.
    Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
    Background.: Nonsevere diarrheal disease in Nepal represents a large burden of illness. Identification of the specific disease-causing pathogens will help target the appropriate control measures. Read More

    Comparative analysis of the predicted secretomes of Rosaceae scab pathogens Venturia inaequalis and V. pirina reveals expanded effector families and putative determinants of host range.
    BMC Genomics 2017 May 2;18(1):339. Epub 2017 May 2.
    The New Zealand Institute for Plant & Food Research Limited (PFR), Auckland, New Zealand.
    Background: Fungal plant pathogens belonging to the genus Venturia cause damaging scab diseases of members of the Rosaceae. In terms of economic impact, the most important of these are V. inaequalis, which infects apple, and V. Read More

    Expert consensus document: Echocardiography and lung ultrasonography for the assessment and management of acute heart failure.
    Nat Rev Cardiol 2017 Jul 27;14(7):427-440. Epub 2017 Apr 27.
    Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
    Echocardiography is increasingly recommended for the diagnosis and assessment of patients with severe cardiac disease, including acute heart failure. Although previously considered to be within the realm of cardiologists, the development of ultrasonography technology has led to the adoption of echocardiography by acute care clinicians across a range of specialties. Data from echocardiography and lung ultrasonography can be used to improve diagnostic accuracy, guide and monitor the response to interventions, and communicate important prognostic information in patients with acute heart failure. Read More

    A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines.
    Sci Rep 2017 Apr 21;7:46426. Epub 2017 Apr 21.
    Infectious Disease Research Institute, 1616 Eastlake Ave E., Seattle WA 98103, USA.
    Since 1997, highly pathogenic avian influenza viruses of the H5N1 subtype have been transmitted from avian hosts to humans. The severity of H5N1 infection in humans, as well as the sporadic nature of H5N1 outbreaks, both geographically and temporally, make generation of an effective vaccine a global public health priority. An effective H5N1 vaccine must ultimately provide protection against viruses from diverse clades. Read More

    Neutrophil-to-lymphocyte ratio as prognostic indicator in gastrointestinal cancers: a systematic review and meta-analysis.
    Oncotarget 2017 May;8(19):32171-32189
    Department of Oncology, University of Utah, Salt Lake City, Utah, USA.
    An accurate, time efficient, and inexpensive prognostic indicator is needed to reduce cost and assist with clinical decision making for cancer management. The neutrophil-to-lymphocyte ratio (NLR), which is derived from common serum testing, has been explored in a variety of cancers. We sought to determine its prognostic value in gastrointestinal cancers and performed a meta-analysis of published studies using the Meta-analysis Of Observational Studies in Epidemiology guidelines. Read More

    Determinants of neurological disease: Synthesis of systematic reviews.
    Neurotoxicology 2017 Apr 12. Epub 2017 Apr 12.
    Brain Research Centre, Department of Medicine (Neurology), University of British Columbia, Vancouver, British Columbia,Canada.
    Systematic reviews were conducted to identify risk factors associated with the onset and progression of 14 neurological conditions, prioritized as a component of the National Population Health Study of Neurological Conditions. These systematic reviews provided a basis for evaluating the weight of evidence of evidence for risk factors for the onset and progression of the 14 individual neurological conditions considered. A number of risk factors associated with an increased risk of onset for more than one condition, including exposure to pesticides (associated with an increased risk of AD, amyotrophic lateral sclerosis, brain tumours, and PD; smoking (AD, MS); and infection (MS, Tourette syndrome). Read More

    Unique Case of Disseminated Plague With Multifocal Osteomyelitis.
    J Pediatric Infect Dis Soc 2017 Apr 4. Epub 2017 Apr 4.
    Division of Pediatric Infectious Diseases.
    Plague is a disease caused by Yersinia pestis. Septicemic and pneumonic plague have a high mortality rate if untreated. Here we describe the challenges of accurately diagnosing a nonfatal pediatric case of septicemic plague with involvement of multiple organs; to our knowledge, the first documented case of multifocal plague osteomyelitis. Read More

    Important malignant and new nail tumors.
    J Dtsch Dermatol Ges 2017 Apr;15(4):367-386
    Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland.
    The nail apparatus is an integral part of the functional unit of the digital tip. Although overall uncommon, all cells and tissues occurring in this area can give rise to neoplastic lesions. Given the special anatomical location, such tumors frequently show morphological and symptom-related differences compared to similar lesions located elsewhere on the skin. Read More

    Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work.
    J Dermatol 2017 Mar 31. Epub 2017 Mar 31.
    Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.
    A 79-year-old Japanese woman presented with an ulcerated, brown-red nodule in the center of a sharply demarcated, tan-brown plaque situated on the left side of her right breast. Histologically, the plaque demonstrated an acanthosis with an intraepidermal epithelioma of Borst-Jadassohn. Small oval nests of bland-appearing basophilic cells in the periphery gradually enlarged into nests of various sizes and irregular shapes, composed of densely cohesive, atypical basophilic cells above the central nodule. Read More

    Dietary patterns and non-communicable disease risk in Indian adults: secondary analysis of Indian Migration Study data.
    Public Health Nutr 2017 Apr 3:1-10. Epub 2017 Apr 3.
    1Department of Population Health,London School of Hygiene & Tropical Medicine,London WC1E 7HT,UK.
    Objective: Undernutrition and non-communicable disease (NCD) are important public health issues in India, yet their relationship with dietary patterns is poorly understood. The current study identified distinct dietary patterns and their association with micronutrient undernutrition (Ca, Fe, Zn) and NCD risk factors (underweight, obesity, waist:hip ratio, hypertension, total:HDL cholesterol, diabetes).

    Design: Data were from the cross-sectional Indian Migration Study, including semi-quantitative FFQ. Read More

    Fluorescence Spectroscopy as a tool to in vivo discrimination of distinctive skin disorders.
    Photodiagnosis Photodyn Ther 2017 Mar 28. Epub 2017 Mar 28.
    Medical School of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900 - Monte Alegre, Ribeirão Preto, SP, 14048-900, Brazil. Electronic address:
    Background: Fast and non-invasive analytical methods, as fluorescence spectroscopy, have potential applications to detect modifications of biochemical and morphologic properties of malignant tissues. In this study, we propose to analyze the fluorescence spectra using k-Nearest Neighbours algorithm (k-NN) and ratio of the fluorescence intensity (FI) to differentiate skin disorders of distinctive etiologies and morphologies.

    Materials And Methods: Laser-induced autofluorescence spectra upon excitation at 408nm were collected from basal cell carcinoma (BCC) subtypes (n=45/212 spectra), psoriasis (PS) (n=37/193 spectra) and Bowen's disease (BD) (n=04/19 spectra) lesions and respective normal skin at sun-exposed (EXP) and non-exposed (NEXP) sites of the same patient. Read More

    Fine-scale transition to lower bacterial diversity and altered community composition precedes shell disease in laboratory-reared juvenile American lobster.
    Dis Aquat Organ 2017 03;124(1):41-54
    Biology Department, University of Massachusetts Boston, Boston, MA 02125, USA.
    The American lobster Homarus americanus supports a valuable commercial fishery in the Northeastern USA and Maritime Canada; however, stocks in the southern portion of the lobster's range have shown declines, in part due to the emergence of shell disease. Epizootic shell disease is a bacterially induced cuticular erosion that renders even mildly affected lobsters unmarketable because of their appearance, and in more severe cases can cause mortality. Despite the importance of this disease, the associated bacterial communities have not yet been fully characterized. Read More

    Photon irradiation using a water bath technique for treatment of confluent carcinoma in situ of the hand, digits, and nail bed: a case report.
    J Med Case Rep 2017 Mar 30;11(1):86. Epub 2017 Mar 30.
    Department of Radiation Oncology, Lankenau Medical Center, 100 Lancaster Avenue, Wynnewood, PA, 19096, USA.
    Background: Confluent squamous cell carcinoma in situ, or Bowen's disease, involving the hand, digit, and nail bed is rare and represents a significant therapeutic challenge. Surgical excision is recommended as first-line treatment but in cases of extensive disease can lead to unacceptable functional morbidity or cosmetic outcomes. Radiation therapy has been shown to be equally efficacious to surgery in the treatment of carcinoma in situ but its use has historically been limited due to concerns regarding toxicity. Read More

    Potential role of the OVOL1-OVOL2 axis and c-Myc in the progression of cutaneous squamous cell carcinoma.
    Mod Pathol 2017 Mar 24. Epub 2017 Mar 24.
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    OVOL1 and OVOL2 are ubiquitously conserved genes encoding C2H2 zinc-finger transcription factors in mammals. They promote epithelial cell proliferation, differentiation, and mesenchymal-to-epithelial transition, coordinately mediated via the Wnt signaling pathway. We previously reported that human OVOL1 and OVOL2 were preferentially expressed in the normal epidermis and hair follicles as well as their tumors, and found that OVOL1 is upregulated in Bowen's disease and downregulated in cutaneous squamous cell carcinoma. Read More

    A systematic review of prognostic factors at the end of life for people with a hematological malignancy.
    BMC Cancer 2017 Mar 23;17(1):213. Epub 2017 Mar 23.
    Queensland University of Technology, Victoria Park Road, N Block, Brisbane, QLD, 4059, Australia.
    Background: Accurate prognosticating is needed when patients are nearing the end of life to ensure appropriate treatment decisions, and facilitate palliative care provision and transitioning to terminal care. People with a hematological malignancy characteristically experience a fluctuating illness trajectory leading to difficulties with prognosticating. The aim of this review was to identify current knowledge regarding 'bedside' prognostic factors in the final 3 months of life for people with a hematological malignancy associated with increased risk of mortality. Read More

    An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management.
    Mar Drugs 2017 Mar 14;15(3). Epub 2017 Mar 14.
    European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall Tr1 3HD, UK.
    Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world. It causes substantial human health, social, and economic impacts. The illness produces a complex array of gastrointestinal, neurological and neuropsychological, and cardiovascular symptoms, which may last days, weeks, or months. Read More

    Experiences of mobility for people living with rheumatoid arthritis who are receiving biologic drug therapy: implications for podiatry services.
    J Foot Ankle Res 2017 16;10:14. Epub 2017 Mar 16.
    Faculty of Health Sciences, University of Southampton, Highfield Campus Building 45, University Road, Southampton, Hampshire SO17 1BJ UK.
    Background: Despite significant advancements in new treatment modalities for rheumatoid arthritis with biological therapies, foot complications remain a disabling and common feature of the disease. In this study the aim was to explore and describe the personal experiences of people with rheumatoid arthritis in receipt of biologic treatments in a bid to understand the impact of this form of medication on their mobility.

    Methods: An interpretative phenomenological analysis (IPA) was undertaken to explore in depth the individual experience of rheumatoid disease through personal accounts of the patient journey spanning both 'before' and 'after' the instigation of biologic therapy. Read More

    Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells.
    Sci Rep 2017 Mar 22;7:45057. Epub 2017 Mar 22.
    Department of Dermatology, PEDEGO Research Unit, Oulu Center for Cell-Matrix Research, MRC Oulu, University of Oulu and Oulu University Hospital, Finland.
    Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We have studied the expression of laminin γ2, collagen XVII and integrin β4 in tissue microarray samples of squamous cell carcinoma (SCC) and its precursors, actinic keratosis and Bowen's disease. Read More

    Porokeratosis simulating Bowen's disease on dermoscopy.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):119-121
    Universidade de Pernambuco (UPE) - Recife (PE), Brazil.
    Porokeratosis is a disorder of epidermal keratinization characterized by the presence of annular hyperkeratotic plaques. Its etiopathogenesis is not yet fully understood, but a relationship with immunosuppression has been reported. Dermoscopic examination revealed a classic yellowish-white ring-like structure that resembled "volcanic crater contour" - the so-called cornoid lamella. Read More

    [A man with Bowen disease of the nail].
    Ned Tijdschr Geneeskd 2017 ;161(0):D933
    Catharina Ziekenhuis, afd. Dermatologie, Eindhoven.
    We describe a 40-year-old male patient with a 2-year history of a sensitive fingernail of the right hand. The nail had partly a rough surface, longitudinal cleavage and was brittle and vulnerable at the tip. Biopsy of the nail showed a Bowen disease (squamous cell carcinoma in situ) of the nail. Read More

    Development of the Physical activity and Your Nutrition for Cancer (PYNC) smartphone app for preventing breast cancer in women.
    Mhealth 2017 15;3. Epub 2017 Feb 15.
    Department of Clinical and Digital Health Sciences, College of Allied Health Sciences, Augusta University, Augusta, GA, USA.
    Background: In the U.S., breast cancer accounts for more cancer deaths in women than any site other than lung cancer. Read More

    Magnetic resonance imaging findings in children with spasmus nutans.
    J AAPOS 2017 Apr 8;21(2):127-130. Epub 2017 Mar 8.
    Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:
    Background: Spasmus nutans (SN) is a rare pediatric ophthalmologic syndrome characterized by nystagmus, head bobbing, and abnormal head positioning. Historically, SN has been associated with underlying optic pathway gliomas (OPG); however, evidence of this association is based primarily on a small number of isolated case reports. Prior retrospective analyses have found the rate of OPG to be <2%, but these studies only intermittently used neuroimaging with computed tomography, which has limited sensitivity for detection of small lesions in the optic pathway. Read More

    Clinical factors of response in patients with advanced ovarian cancer participating in early phase clinical trials.
    Eur J Cancer 2017 May 6;76:52-59. Epub 2017 Mar 6.
    Royal Marsden NHS Foundation Trust, Downs Road, London SM2 5PT, UK; The Institute of Cancer Research, Cotswold Road, London SM2 5NG, UK. Electronic address:
    Drug resistance to conventional anticancer therapies is almost inevitable in patients with advanced ovarian cancer (AOC), limiting their available treatment options. Novel phase I trial therapies within a dedicated drug development unit may represent a viable alternative; however, there is currently little evidence for patient outcomes in such patients. To address this, we undertook a retrospective review of patients with AOC allocated to phase I trials in the Drug Development Unit at Royal Marsden Hospital (RMH) between June 1998 and October 2010. Read More

    Donovanosis With Bowen Disease.
    Skinmed 2017 1;15(1):73-75. Epub 2017 Feb 1.
    Silver Oaks Multispecialty Hospital, Mohali, Punjab, India.
    A 45-year-old farmer presented with ulcers and plaques over his scrotum for the past 4 to 5 years. The condition started as a small lesion on the shaft of the penis, which improved with treatment; however, after 2 to 3 months, papulonodular lesions developed on the scrotum, which increased in size and subsequently broke down to form ulcers. He denied drug abuse but had a history of multiple unprotected sexual exposures. Read More

    Topical ingenol mebutate: a new treatment modality for multiple actinic keratoses and field cancerization.
    Anticancer Agents Med Chem 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatovenereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
    Background: Ingenol mebutate gel is a recent stirring weapon recommended for the treatment of multiple actinic keratoses (AKs) and field cancerization. This review brings a summary of recent data on the treatment of AKs with ingenol mebutate (IM) providing critical commentary with regard to drug&#039;s characteristics, drug&#039;s safety profile, treatment regimen, treatment outcome, patient compliance, AK recurrence, cost-effectiveness and cost-utility, as well as guidelines for the management of the treatment of AK.

    Method: We undertook a structured search of bibliographic databases for peer-reviewed scientific articles, including review articles, original research articles as well as case report articles based on inclusion/exclusion criteria. Read More

    Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) in the adolescent population.
    J Pediatr Urol 2017 Apr 17;13(2):223-224. Epub 2017 Feb 17.
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:
    Background: Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) has built on success and techniques of laparoscopic RPLND, with the added benefits of robotic technology. This paper demonstrates use of the da Vinci Xi(®) system for RA-RPLND in two adolescent patients.

    Methods: Case #1: A 17-year-old male presented with a left testicular mass and elevated alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG). Read More

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