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    4146 results match your criteria Bowen Disease

    1 OF 83

    A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines.
    Sci Rep 2017 Apr 21;7:46426. Epub 2017 Apr 21.
    Infectious Disease Research Institute, 1616 Eastlake Ave E., Seattle WA 98103, USA.
    Since 1997, highly pathogenic avian influenza viruses of the H5N1 subtype have been transmitted from avian hosts to humans. The severity of H5N1 infection in humans, as well as the sporadic nature of H5N1 outbreaks, both geographically and temporally, make generation of an effective vaccine a global public health priority. An effective H5N1 vaccine must ultimately provide protection against viruses from diverse clades. Read More

    Neutrophil-to-lymphocyte ratio as prognostic indicator in gastrointestinal cancers: a systematic review and meta-analysis.
    Oncotarget 2017 Mar 16. Epub 2017 Mar 16.
    Department of Oncology, University of Utah, Salt Lake City, Utah, USA.
    An accurate, time efficient, and inexpensive prognostic indicator is needed to reduce cost and assist with clinical decision making for cancer management. The neutrophil-to-lymphocyte ratio (NLR), which is derived from common serum testing, has been explored in a variety of cancers. We sought to determine its prognostic value in gastrointestinal cancers and performed a meta-analysis of published studies using the Meta-analysis Of Observational Studies in Epidemiology guidelines. Read More

    Determinaical disease: Synthesis of systematic reviews.
    Neurotoxicology 2017 Apr 11. Epub 2017 Apr 11.
    Brain Research Centre, Department of Medicine (Neurology), University of British Columbia, Vancouver, British Columbia, Canada.
    Systematic reviews were conducted to identify risk factors associated with the onset and progression of 14 neurological conditions, prioritized as a component of the National Population Health Study of Neurological Conditions. These systematic reviews provided a basis for evaluating the weight of evidence of evidence for risk factors for the onset and progression of the 14 individual neurological conditions considered. A number of risk factors associated with an increased risk of onset for more than one condition, including exposure to pesticides (associated with an increased risk of AD, amyotrophic lateral sclerosis, brain tumours, and PD; smoking (AD, MS); and infection (MS, Tourette syndrome). Read More

    Unique Case of Disseminated Plague With Multifocal Osteomyelitis.
    J Pediatric Infect Dis Soc 2017 Apr 4. Epub 2017 Apr 4.
    Division of Pediatric Infectious Diseases.
    Plague is a disease caused by Yersinia pestis. Septicemic and pneumonic plague have a high mortality rate if untreated. Here we describe the challenges of accurately diagnosing a nonfatal pediatric case of septicemic plague with involvement of multiple organs; to our knowledge, the first documented case of multifocal plague osteomyelitis. Read More

    Important malignant and new nail tumors.
    J Dtsch Dermatol Ges 2017 Apr;15(4):367-386
    Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland.
    The nail apparatus is an integral part of the functional unit of the digital tip. Although overall uncommon, all cells and tissues occurring in this area can give rise to neoplastic lesions. Given the special anatomical location, such tumors frequently show morphological and symptom-related differences compared to similar lesions located elsewhere on the skin. Read More

    Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work.
    J Dermatol 2017 Mar 31. Epub 2017 Mar 31.
    Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.
    A 79-year-old Japanese woman presented with an ulcerated, brown-red nodule in the center of a sharply demarcated, tan-brown plaque situated on the left side of her right breast. Histologically, the plaque demonstrated an acanthosis with an intraepidermal epithelioma of Borst-Jadassohn. Small oval nests of bland-appearing basophilic cells in the periphery gradually enlarged into nests of various sizes and irregular shapes, composed of densely cohesive, atypical basophilic cells above the central nodule. Read More

    Dietary patterns and non-communicable disease risk in Indian adults: secondary analysis of Indian Migration Study data.
    Public Health Nutr 2017 Apr 3:1-10. Epub 2017 Apr 3.
    1Department of Population Health,London School of Hygiene & Tropical Medicine,London WC1E 7HT,UK.
    Objective: Undernutrition and non-communicable disease (NCD) are important public health issues in India, yet their relationship with dietary patterns is poorly understood. The current study identified distinct dietary patterns and their association with micronutrient undernutrition (Ca, Fe, Zn) and NCD risk factors (underweight, obesity, waist:hip ratio, hypertension, total:HDL cholesterol, diabetes).

    Design: Data were from the cross-sectional Indian Migration Study, including semi-quantitative FFQ. Read More

    Fluorescence Spectroscopy as a tool to in vivo discrimination of distinctive skin disorders.
    Photodiagnosis Photodyn Ther 2017 Mar 28. Epub 2017 Mar 28.
    Medical School of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900 - Monte Alegre, Ribeirão Preto, SP, 14048-900, Brazil. Electronic address:
    Background: Fast and non-invasive analytical methods, as fluorescence spectroscopy, have potential applications to detect modifications of biochemical and morphologic properties of malignant tissues. In this study, we propose to analyze the fluorescence spectra using k-Nearest Neighbours algorithm (k-NN) and ratio of the fluorescence intensity (FI) to differentiate skin disorders of distinctive etiologies and morphologies.

    Materials And Methods: Laser-induced autofluorescence spectra upon excitation at 408nm were collected from basal cell carcinoma (BCC) subtypes (n=45/212 spectra), psoriasis (PS) (n=37/193 spectra) and Bowen's disease (BD) (n=04/19 spectra) lesions and respective normal skin at sun-exposed (EXP) and non-exposed (NEXP) sites of the same patient. Read More

    Fine-scale transition to lower bacterial diversity and altered community composition precedes shell disease in laboratory-reared juvenile American lobster.
    Dis Aquat Organ 2017 Mar;124(1):41-54
    Biology Department, University of Massachusetts Boston, Boston, MA 02125, USA.
    The American lobster Homarus americanus supports a valuable commercial fishery in the Northeastern USA and Maritime Canada; however, stocks in the southern portion of the lobster's range have shown declines, in part due to the emergence of shell disease. Epizootic shell disease is a bacterially induced cuticular erosion that renders even mildly affected lobsters unmarketable because of their appearance, and in more severe cases can cause mortality. Despite the importance of this disease, the associated bacterial communities have not yet been fully characterized. Read More


    Photon irradiation using a water bath technique for treatment of confluent carcinoma in situ of the hand, digits, and nail bed: a case report.
    J Med Case Rep 2017 Mar 30;11(1):86. Epub 2017 Mar 30.
    Department of Radiation Oncology, Lankenau Medical Center, 100 Lancaster Avenue, Wynnewood, PA, 19096, USA.
    Background: Confluent squamous cell carcinoma in situ, or Bowen's disease, involving the hand, digit, and nail bed is rare and represents a significant therapeutic challenge. Surgical excision is recommended as first-line treatment but in cases of extensive disease can lead to unacceptable functional morbidity or cosmetic outcomes. Radiation therapy has been shown to be equally efficacious to surgery in the treatment of carcinoma in situ but its use has historically been limited due to concerns regarding toxicity. Read More

    Potential role of the OVOL1-OVOL2 axis and c-Myc in the progression of cutaneous squamous cell carcinoma.
    Mod Pathol 2017 Mar 24. Epub 2017 Mar 24.
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    OVOL1 and OVOL2 are ubiquitously conserved genes encoding C2H2 zinc-finger transcription factors in mammals. They promote epithelial cell proliferation, differentiation, and mesenchymal-to-epithelial transition, coordinately mediated via the Wnt signaling pathway. We previously reported that human OVOL1 and OVOL2 were preferentially expressed in the normal epidermis and hair follicles as well as their tumors, and found that OVOL1 is upregulated in Bowen's disease and downregulated in cutaneous squamous cell carcinoma. Read More

    A systematic review of prognostic factors at the end of life for people with a hematological malignancy.
    BMC Cancer 2017 Mar 23;17(1):213. Epub 2017 Mar 23.
    Queensland University of Technology, Victoria Park Road, N Block, Brisbane, QLD, 4059, Australia.
    Background: Accurate prognosticating is needed when patients are nearing the end of life to ensure appropriate treatment decisions, and facilitate palliative care provision and transitioning to terminal care. People with a hematological malignancy characteristically experience a fluctuating illness trajectory leading to difficulties with prognosticating. The aim of this review was to identify current knowledge regarding 'bedside' prognostic factors in the final 3 months of life for people with a hematological malignancy associated with increased risk of mortality. Read More

    An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management.
    Mar Drugs 2017 Mar 14;15(3). Epub 2017 Mar 14.
    European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall Tr1 3HD, UK.
    Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world. It causes substantial human health, social, and economic impacts. The illness produces a complex array of gastrointestinal, neurological and neuropsychological, and cardiovascular symptoms, which may last days, weeks, or months. Read More

    Experiences of mobility for people living with rheumatoid arthritis who are receiving biologic drug therapy: implications for podiatry services.
    J Foot Ankle Res 2017 16;10:14. Epub 2017 Mar 16.
    Faculty of Health Sciences, University of Southampton, Highfield Campus Building 45, University Road, Southampton, Hampshire SO17 1BJ UK.
    Background: Despite significant advancements in new treatment modalities for rheumatoid arthritis with biological therapies, foot complications remain a disabling and common feature of the disease. In this study the aim was to explore and describe the personal experiences of people with rheumatoid arthritis in receipt of biologic treatments in a bid to understand the impact of this form of medication on their mobility.

    Methods: An interpretative phenomenological analysis (IPA) was undertaken to explore in depth the individual experience of rheumatoid disease through personal accounts of the patient journey spanning both 'before' and 'after' the instigation of biologic therapy. Read More

    Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells.
    Sci Rep 2017 Mar 22;7:45057. Epub 2017 Mar 22.
    Department of Dermatology, PEDEGO Research Unit, Oulu Center for Cell-Matrix Research, MRC Oulu, University of Oulu and Oulu University Hospital, Finland.
    Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We have studied the expression of laminin γ2, collagen XVII and integrin β4 in tissue microarray samples of squamous cell carcinoma (SCC) and its precursors, actinic keratosis and Bowen's disease. Read More

    Porokeratosis simulating Bowen's disease on dermoscopy.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):119-121
    Universidade de Pernambuco (UPE) - Recife (PE), Brazil.
    Porokeratosis is a disorder of epidermal keratinization characterized by the presence of annular hyperkeratotic plaques. Its etiopathogenesis is not yet fully understood, but a relationship with immunosuppression has been reported. Dermoscopic examination revealed a classic yellowish-white ring-like structure that resembled "volcanic crater contour" - the so-called cornoid lamella. Read More

    [A man with Bowen disease of the nail].
    Ned Tijdschr Geneeskd 2017 ;161(0):D933
    Catharina Ziekenhuis, afd. Dermatologie, Eindhoven.
    We describe a 40-year-old male patient with a 2-year history of a sensitive fingernail of the right hand. The nail had partly a rough surface, longitudinal cleavage and was brittle and vulnerable at the tip. Biopsy of the nail showed a Bowen disease (squamous cell carcinoma in situ) of the nail. Read More

    Development of the Physical activity and Your Nutrition for Cancer (PYNC) smartphone app for preventing breast cancer in women.
    Mhealth 2017 15;3. Epub 2017 Feb 15.
    Department of Clinical and Digital Health Sciences, College of Allied Health Sciences, Augusta University, Augusta, GA, USA.
    Background: In the U.S., breast cancer accounts for more cancer deaths in women than any site other than lung cancer. Read More

    Magnetic resonance imaging findings in children with spasmus nutans.
    J AAPOS 2017 Apr 8;21(2):127-130. Epub 2017 Mar 8.
    Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:
    Background: Spasmus nutans (SN) is a rare pediatric ophthalmologic syndrome characterized by nystagmus, head bobbing, and abnormal head positioning. Historically, SN has been associated with underlying optic pathway gliomas (OPG); however, evidence of this association is based primarily on a small number of isolated case reports. Prior retrospective analyses have found the rate of OPG to be <2%, but these studies only intermittently used neuroimaging with computed tomography, which has limited sensitivity for detection of small lesions in the optic pathway. Read More

    Clinical factors of response in patients with advanced ovarian cancer participating in early phase clinical trials.
    Eur J Cancer 2017 May 6;76:52-59. Epub 2017 Mar 6.
    Royal Marsden NHS Foundation Trust, Downs Road, London SM2 5PT, UK; The Institute of Cancer Research, Cotswold Road, London SM2 5NG, UK. Electronic address:
    Drug resistance to conventional anticancer therapies is almost inevitable in patients with advanced ovarian cancer (AOC), limiting their available treatment options. Novel phase I trial therapies within a dedicated drug development unit may represent a viable alternative; however, there is currently little evidence for patient outcomes in such patients. To address this, we undertook a retrospective review of patients with AOC allocated to phase I trials in the Drug Development Unit at Royal Marsden Hospital (RMH) between June 1998 and October 2010. Read More

    Donovanosis With Bowen Disease.
    Skinmed 2017 1;15(1):73-75. Epub 2017 Feb 1.
    Silver Oaks Multispecialty Hospital, Mohali, Punjab, India.
    A 45-year-old farmer presented with ulcers and plaques over his scrotum for the past 4 to 5 years. The condition started as a small lesion on the shaft of the penis, which improved with treatment; however, after 2 to 3 months, papulonodular lesions developed on the scrotum, which increased in size and subsequently broke down to form ulcers. He denied drug abuse but had a history of multiple unprotected sexual exposures. Read More

    Topical ingenol mebutate: a new treatment modality for multiple actinic keratoses and field cancerization.
    Anticancer Agents Med Chem 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatovenereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
    Background: Ingenol mebutate gel is a recent stirring weapon recommended for the treatment of multiple actinic keratoses (AKs) and field cancerization. This review brings a summary of recent data on the treatment of AKs with ingenol mebutate (IM) providing critical commentary with regard to drug&#039;s characteristics, drug&#039;s safety profile, treatment regimen, treatment outcome, patient compliance, AK recurrence, cost-effectiveness and cost-utility, as well as guidelines for the management of the treatment of AK.

    Method: We undertook a structured search of bibliographic databases for peer-reviewed scientific articles, including review articles, original research articles as well as case report articles based on inclusion/exclusion criteria. Read More

    Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) in the adolescent population.
    J Pediatr Urol 2017 Feb 17. Epub 2017 Feb 17.
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:
    Background: Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) has built on success and techniques of laparoscopic RPLND, with the added benefits of robotic technology. This paper demonstrates use of the da Vinci Xi(®) system for RA-RPLND in two adolescent patients.

    Methods: Case #1: A 17-year-old male presented with a left testicular mass and elevated alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG). Read More

    Preoperative Use of Clopidogrel Does Not Affect Outcomes for Femoral Neck Fractures Treated With Hemiarthroplasty.
    J Arthroplasty 2017 Feb 3. Epub 2017 Feb 3.
    Department of Orthopedics at Geisinger Medical Center, Danville, Pennsylvania.
    Background: The antiplatelet effect of clopidogrel on blood loss and perioperative complications after surgical intervention remains ambiguous. The purpose of this study was to determine if patients on clopidogrel before hemiarthroplasty for femoral neck fracture are predisposed to greater surgical bleeding and perioperative complications compared with those not taking clopidogrel before surgery.

    Methods: We conducted a review of our electronic medical record from 2006-2013 and identified 602 patients who underwent 623 hemiarthroplasty procedures for displaced femoral neck fracture, of which 54 cases (9%) were taking clopidogrel before hospital admission. Read More

    Topics in histopathology of sweat gland and sebaceous neoplasms.
    J Dermatol 2017 Mar;44(3):315-326
    Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki City, Japan.
    This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Read More

    Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis.
    JAMA Neurol 2017 Apr;74(4):459-469
    Haematology Department, Careggi University Hospital, Firenze, Italy.
    Importance: Autologous hematopoietic stem cell transplantation (AHSCT) may be effective in aggressive forms of multiple sclerosis (MS) that fail to respond to standard therapies.

    Objective: To evaluate the long-term outcomes in patients who underwent AHSCT for the treatment of MS in a large multicenter cohort.

    Design, Setting, And Participants: Data were obtained in a multicenter, observational, retrospective cohort study. Read More

    Molecular prevalence of Merkel cell polyomavirus in nonmelanoma skin cancer in a Brazilian population.
    Clin Exp Dermatol 2017 Feb 27. Epub 2017 Feb 27.
    Department of Clinical Medicine, Universidade Federal Fluminense, Hospital Universitário Antônio Pedro, Niterói, Rio de Janeiro, Brazil.
    Background: Merkel cell polyomavirus (MCPyV), a newly described oncogenic virus, has been found in association with tumours other than Merkel cell carcinoma (MCC). As yet, little is known about the involvement or influence of MCPyV on the development of these tumours and its prevalence in various populations.

    Aim: To assess the prevalence of MCPyV DNA in cases of nonmelanoma skin cancer (NMSC). Read More

    Photodynamic Therapy and Skin Appendage Disorders: A Review.
    Skin Appendage Disord 2017 Jan 8;2(3-4):166-176. Epub 2016 Dec 8.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. Read More

    Important Treatment Outcomes for Patients with Psoriatic Arthritis: A Multisite Qualitative Study.
    Patient 2017 Feb 22. Epub 2017 Feb 22.
    Royal National Hospital for Rheumatic Diseases, Bath, UK.
    Background: Psoriatic arthritis (PsA) is a variable and complex inflammatory condition. Symptoms can compromise physical function, reduce quality of life, and accrue significant health costs. Commonly used patient-reported outcomes largely reflect the professionals' perspective, however it is not known whether they capture what is important to patients. Read More

    A case of pigmented Bowen's disease.
    An Bras Dermatol 2017 Jan-Feb;92(1):124-125
    Pathology Department of the Federal University of São Paulo (Unifesp) - São Paulo (SP), Brazil.
    Pigmented Bowen's disease is a rare subtype of Bowen's disease. Clinically it presents as a slow-growing, well-defined, hyperpigmented plaque, and should be included as a differential diagnosis of other pigmented lesions. The authors describe a challenging case of pigmented Bowen's disease with non-diagnostic dermscopy findings. Read More

    Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides.
    Ann Dermatol 2017 Feb 3;29(1):79-82. Epub 2017 Feb 3.
    Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
    Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented with a 6-month history of asymptomatic multiple yellowish plaques on both legs. She had been diagnosed with mycosis fungoides 7 years ago and was treated with psoralen and ultraviolet A radiation (PUVA) therapy, narrow-band ultraviolet B (UVB) therapy, and acitretin for 5 years. Read More

    Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease.
    Alzheimers Dement 2017 Feb 21. Epub 2017 Feb 21.
    Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address:
    Introduction: Findings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits.

    Methods: We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators. Read More

    CD6 as a potential target for treating multiple sclerosis.
    Proc Natl Acad Sci U S A 2017 Mar 16;114(10):2687-2692. Epub 2017 Feb 16.
    Department of Immunology, Cleveland Clinic, Cleveland, OH 44195;
    CD6 was established as a marker of T cells more than three decades ago, and recent studies have identified CD6 as a risk gene for multiple sclerosis (MS), a disease in which autoreactive T cells are integrally involved. Nevertheless, the precise role of CD6 in regulating T-cell responses is controversial and its significance in the pathogenesis of various diseases remains elusive, partly due to the lack of animals engineered to alter expression of the CD6 gene. In this report, we found that CD6 KO mice showed decreased pathogenic T-cell responses, reduced spinal cord T-cell infiltration, and attenuated disease severity in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Read More

    Frequent Zika Virus Sexual Transmission and Prolonged Viral RNA Shedding in an Immunodeficient Mouse Model.
    Cell Rep 2017 Feb;18(7):1751-1760
    Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA. Electronic address:
    Circulation of Zika virus (ZIKV) was first identified in the Western hemisphere in late 2014. Primarily transmitted through mosquito bite, ZIKV can also be transmitted through sex and from mother to fetus, and maternal ZIKV infection has been associated with fetal malformations. We assessed immunodeficient AG129 mice for their capacity to shed ZIKV in semen and to infect female mice via sexual transmission. Read More

    Effectiveness of photodynamic therapy in refractory plaque-stage mycosis fungoides associated with Bowen's disease.
    Dermatol Ther 2017 Feb 15. Epub 2017 Feb 15.
    Department of Clinical-Surgical, Diagnostic and Pediatric Science, Institute of Dermatology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

    Effectiveness of photodynamic therapy in Bowen's disease: a retrospective observational study in 423 lesions.
    J Eur Acad Dermatol Venereol 2017 Feb 11. Epub 2017 Feb 11.
    Department of Dermatology and Venereology, Sahlgrenska University Hospital, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Background: Photodynamic therapy (PDT) is a well-known technique that is often used for treating superficial precancerous and cancerous skin lesions. However, only a handful of studies, with a relatively small number of treated lesions, have been carried out on the effectiveness of PDT for Bowen's disease (BD).

    Objectives: This study aimed to assess the effectiveness and recurrence risk of PDT in the treatment of BD. Read More

    Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease.
    PLoS One 2017 10;12(2):e0171480. Epub 2017 Feb 10.
    Liver Injury and Cancer, Centenary Institute, Camperdown, New South Wales, Australia.
    Canonical Hedgehog (Hh) signaling in vertebrate cells occurs following Smoothened activation/translocation into the primary cilia (Pc), followed by a GLI transcriptional response. Nonetheless, GLI activation can occur independently of the canonical Hh pathway. Using a murine model of liver injury, we previously identified the importance of canonical Hh signaling within the Pc+ liver progenitor cell (LPC) population and noted that SMO-independent, GLI-mediated signals were important in multiple Pc-ve GLI2+ intrahepatic populations. Read More

    Transethnic genome-wide scan identifies novel Alzheimer's disease loci.
    Alzheimers Dement 2017 Feb 7. Epub 2017 Feb 7.
    Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA. Electronic address:
    Introduction: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.

    Methods: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. Read More

    Outcome of Flap Surgeries in Dermatosurgical Unit at a Tertiary Care Centre in India with a Review of Literature.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):226-231
    Department of Dermatology, Bangalore Medical College and Research Institute, Victoria Hospital, Bengaluru, Karnataka, India.
    Introduction: Flap surgeries are an excellent choice for closing large defects following trauma, excision of carcinomas or removal of large lesions. This article is a prospective interventional study of various flap surgeries performed at a tertiary care centre with their outcome in dermatosurgical unit.

    Materials And Methods: A total of 35 flap surgeries performed from January 2012 to December 2014 formed part of the study. Read More

    High-dose immunosuppressive therapy and autologous HCT for relapsing-remitting MS.
    Neurology 2017 Feb 1;88(9):842-852. Epub 2017 Feb 1.
    From the Colorado Blood Cancer Institute (R.A.N.), Denver; Baylor College of Medicine (G.J.H.), Houston, TX; Ohio State University (M.K.R., S.M.D.), Columbus; MD Anderson Cancer Research Center (U.P.), Houston, TX; Rho, Inc. (K.C.S.), Chapel Hill, NC; National Institute of Allergy and Infectious Diseases (L.M.G.), National Institutes of Health, Bethesda, MD; Division of Brain Sciences (P.A.M.), Imperial College London, UK; City of Hope National Medical Center (H.O.), Duarte, CA; Immune Tolerance Network (P.H.S.), University of California San Francisco; University of Texas Southwestern (O.S.), Dallas; NeuroRx (D.L.A.), McGill University, Montreal, Canada; Fred Hutchinson Cancer Research Center (G.E.G.), University of Washington (M.H.W., A.W., G.H.K.); and Swedish Hospital Medical Center (J.D.B.), Seattle, WA.
    Objective: To evaluate the safety, efficacy, and durability of multiple sclerosis (MS) disease stabilization after high-dose immunosuppressive therapy (HDIT) and autologous hematopoietic cell transplantation (HCT).

    Methods: High-Dose Immunosuppression and Autologous Transplantation for Multiple Sclerosis (HALT-MS) is a phase II clinical trial of HDIT/HCT for patients with relapsing-remitting (RR) MS who experienced relapses with disability progression (Expanded Disability Status Scale [EDSS] 3.0-5. Read More

    Brain pathology of a patient 7years after autologous hematopoietic stem cell transplantation for multiple sclerosis.
    J Neurol Sci 2017 Feb 7;373:339-341. Epub 2017 Jan 7.
    University of Alberta, Department of Pathology, Edmonton, Alberta, Canada.
    Aggressive immunosuppression followed by autologous hematopoietic stem cell transplantation (aHSCT) can be an effective treatment for severe multiple sclerosis (MS), but not all stages of disease may benefit equally. The case of a 49-year-old woman with advanced secondary-progressive MS whose clinical course was not improved by aHSCT and who seven years after transplantation succumbed to complications of severe MS disease-related disability is presented. Autopsy findings of ongoing neurodegeneration despite only rare infiltrating T-lymphocytes illustrate that late MS disease may not represent a suitable disease stage for aHSCT. Read More

    Complete response to azacitidine priming and nab-paclitaxel in non-Hodgkin lymphoma resistant to biochemotherapy.
    Mol Clin Oncol 2017 Jan 23;6(1):122-124. Epub 2016 Nov 23.
    Department of Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake, UT 84112, USA.
    The standard of care for first-line therapy in diffuse large B-cell lymphoma (DLBCL) is the rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) regimen. For patients who fail to respond, have an incomplete response or relapse, numerous effective options exists besides salvage cisplatin-based regimen and autologous stem cell therapy. Even with this approach, the outcome remains very poor for this group of patients. Read More

    One year mirror-image study using paliperidone palmitate for relapse prevention of schizophrenia in four university hospitals in Canada.
    Schizophr Res 2017 Jan 21. Epub 2017 Jan 21.
    Department of pharmacy, Hôpital Maisonneuve-Rosemont, 5415 boulevard de l'Assomption, Montreal, Quebec H1T 2M4, Canada; Faculty of pharmacy, Université de Montréal, 2940 Chemin de la Polytechnique, Montreal, Quebec H3T 1J4, Canada.
    Background: Superiority of long acting injectable antipsychotics (LAI) over oral antipsychotics remains controversial and dependent on study design and inclusion criteria. Meta-analysis of 21 RCTs demonstrated no difference in their effectiveness, but meta-analysis of 25 mirror-image studies did. None of these included paliperidone palmitate (PP). Read More

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