Search our Database of Scientific Publications and Authors

I’m looking for a

    4265 results match your criteria Bowen Disease

    1 OF 86

    Pigmented Bowen's disease associated with high-risk HPV simulating melanoma of the hand.
    An Bras Dermatol 2017 Sep-Oct;92(5):686-688
    Private clinic - Piracicaba (SP), Brazil.
    Bowen's disease is an in situ squamous cell carcinoma of the skin with only 2% of pigmented cases reported. It is clinically characterized by papules and plaques of blackened surface that may be caused either by sun damage - usually in photoexposed areas in elderly individuals - or by human papillomavirus infection - usually in the anogenital region of young adults. Dermoscopic aspects of Bowen's disease are discussed for over a decade, but with no definitive criteria that would lead to a definitive diagnosis. Read More

    Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers.
    Eur J Dermatol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
    In mouse skin models, mast cells have been shown to express vitamin D receptor (VDR) that can mediate the immunosuppressive effects of ultraviolet B radiation and vitamin D3. However, VDR activation leads to the expression of CYP24A1, a hydroxylase that can inactivate vitamin D3 metabolites. To examine immunoreactivity to VDR and CYP24A1 in mast cells from normal human skin, keratinocyte skin cancers, and disorders of chronic inflammation. Read More

    Actinic keratosis area and severity index (AKASI) is associated with the incidence of squamous cell carcinoma.
    J Eur Acad Dermatol Venereol 2017 Nov 8. Epub 2017 Nov 8.
    CentroDerm Clinic, Heinz-Fangman-Straße 57, Wuppertal, Germany.
    Background: Actinic keratoses (AKs) are commonly diagnosed clinically. Actinic keratosis area and severity index (AKASI) is a new easy-to-use tool to assess the severity of AK on the head.

    Objective: To determine the association between chronically UV-induced tumours such as basal cell carcinomas (BCC) or squamous cell carcinomas (SCC) and AKASI. Read More

    A Zika Vaccine Targeting NS1 Protein Protects Immunocompetent Adult Mice in a Lethal Challenge Model.
    Sci Rep 2017 Nov 7;7(1):14769. Epub 2017 Nov 7.
    Geovax, Smyrna, GA, United States.
    Zika virus (ZIKV) is a mosquito-borne flavivirus that has rapidly extended its geographic range around the world. Its association with abnormal fetal brain development, sexual transmission, and lack of a preventive vaccine have constituted a global health concern. Designing a safe and effective vaccine requires significant caution due to overlapping geographical distribution of ZIKV with dengue virus (DENV) and other flaviviruses, possibly resulting in more severe disease manifestations in flavivirus immune vaccinees such as Antibody-Dependent Enhancement (ADE, a phenomenon involved in pathogenesis of DENV, and a risk associated with ZIKV vaccines using the envelope proteins as immunogens). Read More

    Factors Influencing Squamous Cell Carcinoma In Situ Recurrence and Implications for Treatment Choice.
    Dermatol Surg 2017 Nov 6. Epub 2017 Nov 6.
    *Department of Internal Medicine, University of Hawaii, Honolulu, Hawaii; †Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
    Background: Numerous treatment modalities have been reported for squamous cell carcinoma in situ (SCCIS). Risk factors for recurrence have not been systematically reviewed.

    Objective: To systematically review and summarize the data on risk factors that contribute to recurrence of SCCIS. Read More

    Cyclin D1 promoter -56 and -54bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen's disease.
    J Dermatol Sci 2017 Oct 31. Epub 2017 Oct 31.
    Department of Dermatology, Kaohsiung Medical University and Hospital, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, Kaohsiung Medical University and Hospital, Kaohsiung, Taiwan; National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Electronic address:
    Background: Patients with arsenic-induced Bowen's disease (As-BD) are at risk of developing invasive cancers in the skin, lung, and urinary bladder. However, a longitudinal follow-up study on the association between As-BD and invasive cancers is still lacking.

    Objectives: This study aims to investigate the underlying molecular mechanisms of this malignant progression in the skin and internal organs. Read More

    Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments.
    Trends Microbiol 2017 Oct 30. Epub 2017 Oct 30.
    Levy Center for Oral Health, Department of Orthodontics, Divisions of Pediatric Dentistry and Community of Oral Health, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA. Electronic address:
    Biofilms are microbial communities embedded within an extracellular matrix, forming a highly organized structure that causes many human infections. Dental caries (tooth decay) is a polymicrobial biofilm disease driven by the diet and microbiota-matrix interactions that occur on a solid surface. Sugars fuel the emergence of pathogens, the assembly of the matrix, and the acidification of the biofilm microenvironment, promoting ecological changes and concerted multispecies efforts that are conducive to acid damage of the mineralized tooth tissue. Read More

    Reticulated acanthoma with sebaceous differentiation mimicking melanoma.
    Dermatol Pract Concept 2017 Jul 31;7(3):35-37. Epub 2017 Jul 31.
    Department of Dermatology, Mogi das Cruzes University, Mogi das Cruzes, Brazil.
    Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. Read More

    EVOLVE: The Australian Rheumatology Association's 'top five' list of investigations and interventions doctors and patients should question.
    Intern Med J 2017 Oct 28. Epub 2017 Oct 28.
    NHMRC Senior Principal Research Fellow; Director, Monash Department of Clinical Epidemiology, Cabrini Institute; and Professor, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
    Background: The EVOLVE (evaluating evidence. enhancing efficiencies) initiative aims to drive safer, higher-quality patient care through identifying and reducing low-value practices.

    Aims: To determine the Australian Rheumatology Association's (ARA's) 'top 5' list of low-value practices. Read More

    Fecal bacterial communities of wild-captured and stranded green turtles (Chelonia mydas) on the Great Barrier Reef.
    FEMS Microbiol Ecol 2017 Oct 23. Epub 2017 Oct 23.
    James Cook University, College of Public Health, Medical and Veterinary Sciences; Hajee Mohammad Danesh Science and Technology University, Faculty of Veterinary and Animal Sciences.
    Green turtles ( Chelonia mydas ) are endangered marine herbivores that break down food particles, primarily sea grasses, through microbial fermentation. However, the microbial community and its role in health and disease are still largely unexplored. In this study, we investigated and compared the fecal bacterial communities of eight wild-captured green turtles to four stranded turtles in the central Great Barrier Reef (GBR) regions that include Bowen and Townsville. Read More

    Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease.
    Alzheimers Dement (N Y) 2017 Jun 24;3(2):166-176. Epub 2017 Feb 24.
    Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
    Introduction: Diagnosis of Alzheimer's disease (AD) in vivo, by molecular imaging of amyloid or tau, is constrained because similar changes can be found in brains of cognitively normal individuals. Butyrylcholinesterase (BChE), which becomes associated with these structures in AD, could elevate the accuracy of AD diagnosis by focusing on BChE pathology in the cerebral cortex, a region of scant BChE activity in healthy brain.

    Methods: N-methylpiperidin-4-yl 4-[(123)I]iodobenzoate, a BChE radiotracer, was injected intravenously into B6SJL-Tg(APPSwFlLon, PSEN1∗M146 L∗L286 V) 6799Vas/Mmjax (5XFAD) mice and their wild-type (WT) counterparts for comparative single photon emission computed tomography (SPECT) studies. Read More

    Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.
    J Natl Cancer Inst 2017 Nov;109(11)
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD; Department of Epidemiology and Cancer Control, Division of Cancer Survivorship, Department of Oncology, Department of Biostatistics, Hartwell Center for Bioinformatics and Biotechnology, and Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN; Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD; Departments of Medicine, Pediatrics, and Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY; Section of Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, University of Chicago, Chicago, IL; Nationwide Children's Hospital and the Ohio State University School of Medicine, Columbus, OH; Department of Pediatrics, University of Minnesota, Minneapolis, MN; Information Management Services, Inc., Calverton, MD; Cancer Prevention and Clinical Statistics Programs and Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Genetics and Department of Radiation Physics, The University of Texas at MD Anderson Cancer Center, Houston, TX; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL.
    Background: Childhood cancer survivors treated with chest-directed radiotherapy have substantially elevated risk for developing breast cancer. Although genetic susceptibility to breast cancer in the general population is well studied, large-scale evaluation of breast cancer susceptibility after chest-directed radiotherapy for childhood cancer is lacking.

    Methods: We conducted a genome-wide association study of breast cancer in female survivors of childhood cancer, pooling two cohorts with detailed treatment data and systematic, long-term follow-up: the Childhood Cancer Survivor Study and St. Read More

    Cell-based therapeutic strategies for multiple sclerosis.
    Brain 2017 11;140(11):2776-2796
    Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
    The availability of multiple disease-modifying medications with regulatory approval to treat multiple sclerosis illustrates the substantial progress made in therapy of the disease. However, all are only partially effective in preventing inflammatory tissue damage in the central nervous system and none directly promotes repair. Cell-based therapies, including immunoablation followed by autologous haematopoietic stem cell transplantation, mesenchymal and related stem cell transplantation, pharmacologic manipulation of endogenous stem cells to enhance their reparative capabilities, and transplantation of oligodendrocyte progenitor cells, have generated substantial interest as novel therapeutic strategies for immune modulation, neuroprotection, or repair of the damaged central nervous system in multiple sclerosis. Read More

    Pre-vaccine circulating group a rotavirus strains in under 5 years children with acute diarrhea during 1999-2013 in Cameroon.
    Virology (Lond) 2017 Aug 25;1(4). Epub 2017 Jul 25.
    Centers for Disease Control and Prevention, Atlanta, GA, USA.
    The aim of this review was to assess all the studies on rotavirus G and P characterization during the pre-vaccine period (1999-2013) in Cameroon to have a better basis for post-vaccine introduction evaluations. A retrospective study was done through a comprehensive review of published (PubMed, Google Scholar) and accessible unpublished data on rotavirus G and P genotypes circulating in five regions of Cameroon. Descriptive data were expressed as frequencies tables and proportions. Read More

    SELECT-2: a Phase II, double-blind, randomised, placebo-controlled study to assess the efficacy of selumetinib plus docetaxel as a second-line treatment for patients with advanced or metastatic non-small cell lung cancer.
    Ann Oncol 2017 Oct 3. Epub 2017 Oct 3.
    Lowe Center for Thoracic Oncology and the Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston MA, USA.
    Background: Combination of selumetinib plus docetaxel provided clinical benefit in a previous Phase II trial for patients with KRAS-mutant advanced non-small cell lung cancer (NSCLC). The Phase II SELECT-2 trial investigated safety and efficacy of selumetinib plus docetaxel for patients with advanced or metastatic NSCLC.

    Patients And Methods: Patients who had disease progression after first-line anti-cancer therapy were randomised (2:2:1) to selumetinib 75 mg BID plus docetaxel 60 mg/m2 or 75 mg/m2 (SEL+DOC 60; SEL+DOC 75), or placebo plus docetaxel 75 mg/m2 (PBO+DOC 75). Read More

    Comparative Metabolomics of Mycoplasma bovis and Mycoplasma gallisepticum Reveals Fundamental Differences in Active Metabolic Pathways and Suggests Novel Gene Annotations.
    mSystems 2017 Sep-Oct;2(5). Epub 2017 Oct 10.
    Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia.
    Mycoplasmas are simple, but successful parasites that have the smallest genome of any free-living cell and are thought to have a highly streamlined cellular metabolism. Here, we have undertaken a detailed metabolomic analysis of two species, Mycoplasma bovis and Mycoplasma gallisepticum, which cause economically important diseases in cattle and poultry, respectively. Untargeted gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry analyses of mycoplasma metabolite extracts revealed significant differences in the steady-state levels of many metabolites in central carbon metabolism, while (13)C stable isotope labeling studies revealed marked differences in carbon source utilization. Read More

    Evaluation of shedding, tissue burdens, and humoral immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence vaccine strain Rev. 1.
    PLoS One 2017 13;12(10):e0185823. Epub 2017 Oct 13.
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America.
    Brucella melitensis is the causative agent of brucellosis in small ruminants and is of considerable economic and public health importance in many countries worldwide. The control of disease in humans depends on the control of disease in livestock; however, few counties with endemic B. melitensis infection have been able to successfully eradicate this pathogen. Read More

    Advances in the understanding and management of mucositis during stem cell transplantation.
    Curr Opin Support Palliat Care 2017 Dec;11(4):341-346
    aAdelaide Medical School, University of Adelaide bCentre for Nutrition and Gastrointestinal Disease, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
    Purpose Of Review: Mucositis is a severe and common side effect of anticancer treatments, with an incidence of between 40 and 80% depending on the cytotoxic regimen used. The most profound mucositis burden is experienced during conditioning regimens for hematopoietic stem cell transplant (HSCT), where the use of highly mucotoxic agents with or without total body irradiation leads to serious damage throughout the alimentary tract. Currently, the assessment and management of both oral and gastrointestinal mucositis lack authoritative guideline, with recommendations only achieved in narrow clinical scenarios. Read More

    Application of Theranostics in Oncology.
    Adv Exp Med Biol 2017 ;989:119-128
    Department of Nursing, Technological Educational Institute of Athens, Athens, Greece.
    In recent years, due to the development of nanotechnology new horizons in treatment and diagnosis of cancer open up. Development of nano-systems for simultaneous transfer of active substances and imaging of tumor regions gathers an important amount of scientific interest. This new category of nano-systems is called Theranostics. Read More

    Individual risk assessment in MDS in the era of genomic medicine.
    Semin Hematol 2017 Jul 24;54(3):133-140. Epub 2017 Aug 24.
    Department of Haematology, Leeds Teaching Hospitals, St. James's Institute of Oncology, Beckett Street, Leeds UK.
    Assessment of risk for patients with myelodysplastic syndromes has evolved from pure morphological bone marrow assessment to a series of validated prognostic scoring systems whose 'risk' assessment is of death (overall survival) or disease progression (AML transformation). The revised International Prognostic Scoring System (2012) improved the precision for prognosis but did not consider patient-specific factors such as comorbidity and performance status, which have a clear impact on outcome, particularly in lower-risk MDS. The improved understanding of MDS biology predominantly through genomic mutational analysis, flow cytometry and gene expression profiling poses a question regarding incorporation of these parameters into the existing scoring systems. Read More

    Total Long-Chain n-3 Fatty Acid Intake and Food Sources in the United States Compared to Recommended Intakes: NHANES 2003-2008.
    Lipids 2017 Nov 27;52(11):917-927. Epub 2017 Sep 27.
    Department of Nutritional Sciences, The University of Arizona, 1177 E. 4th St., 309 Shantz Bldg, Tucson, AZ, 85721, USA.
    The American Heart Association recommends consuming fish (particularly oily fish) at least two times per week, which would provide ≈ 0.5 g/day of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) for cardiovascular disease risk reduction. Previous analyses indicate that this recommendation is not being met; however, few studies have assessed different ethnicities, subpopulations requiring additional n-3 fatty acid intake (i. Read More

    The Multidimensional Therapeutic Potential of Targeting the Brain Oxytocin System for the Treatment of Substance Use Disorders.
    Curr Top Behav Neurosci 2017 Sep 24. Epub 2017 Sep 24.
    Department of Behavioural and Molecular Neurobiology, Regensburg Center of Neuroscience, University of Regensburg, 93053, Regensburg, Germany.
    The neuropeptide oxytocin is released both into the blood and within the brain in response to reproductive stimuli, such as birth, suckling and sex, but also in response to social interaction and stressors. Substance use disorders, or addictions, are chronic, relapsing brain disorders and are one of the major causes of global burden of disease. Unfortunately, current treatment options for substance use disorders are extremely limited and a treatment breakthrough is sorely needed. Read More

    Epidermodysplasia verruciformis: three case reports and a brief review.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 09;26(3):59-61
    Department of Dermatology, Safdarjung Hospital, New Delhi, India.
    Epidermodyplasia verruciformis (EV) is a rare heritable disease that is characterized by an increased susceptibility to infection with specific human papillomavirus (HPV) types due to a defect in cell-mediated immune response to HPV infection. Widespread infection with HPV is responsible for the development of wart-like lesions and pityriasis versicolor-like spots. These individuals have a lifelong risk of developing cutaneous malignancies, especially Bowen's disease and squamous cell carcinoma, mainly in sun-exposed parts. Read More

    Trends in utilization and costs of BRCA testing among women aged 18-64 years in the United States, 2003-2014.
    Genet Med 2017 Sep 21. Epub 2017 Sep 21.
    Office of Public Health Genomics; Center for Surveillance, Epidemiology and Laboratory Services, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
    PurposeWe examined 12-year trends in BRCA testing rates and costs in the context of clinical guidelines, national policies, and other factors.MethodsWe estimated trends in BRCA testing rates and costs from 2003 to 2014 for women aged 18-64 years using private claims data and publicly reported revenues from the primary BRCA testing provider.ResultsThe percentage of women with zero out-of-pocket payments for BRCA testing increased during 2013-2014, after 7 years of general decline, coinciding with a clarification of Affordable Care Act coverage of BRCA genetic testing. Read More

    Polydactylous Bowen's Disease in an Immunocompromised Patient: Resolution of All Lesions After Mohs Surgery on a Single Lesion.
    Dermatol Surg 2017 Sep 19. Epub 2017 Sep 19.
    Brody School of Medicine, East Carolina University, Greenville, North Carolina Department of Dermatology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina Coastal Carolina Pathology, Wilmington, North Carolina Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

    Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure.
    Sci Rep 2017 Sep 13;7(1):11487. Epub 2017 Sep 13.
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
    Vδ2(+) γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria. The role of these cells in mediating clinical immunity (i. Read More

    Comparison of three multiplex gastrointestinal platforms for the detection of gastroenteritis viruses.
    J Clin Virol 2017 Oct 1;95:66-71. Epub 2017 Sep 1.
    Division of Viral Diseases, National Center for Immunizations and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address:
    Background: Viruses are major etiological agents of childhood gastroenteritis. In recent years, several molecular platforms for the detection of viral enteric pathogens have become available.

    Objective/study Design: We evaluated the performance of three multiplex platforms including Biofire's Gastrointestinal Panel (FilmArray), Luminex xTAG(®) Gastrointestinal Pathogen Panel (GPP), and the TaqMan Array Card (TAC) for the detection of five gastroenteritis viruses using a coded panel of 300 archived stool samples. Read More

    Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent Urinary Tract Infection.
    Sci Rep 2017 Sep 8;7(1):11039. Epub 2017 Sep 8.
    Institutes of Cell & Molecular Biosciences and Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
    The identification of the host defence peptides as target effectors in the innate defence of the uro-genital tract creates new translational possibilities for immunomodulatory therapies, specifically vaginal therapies to treat women suffering from rUTI, particularly those carrying the TLR5_C1174T SNP. Urinary tract infections (UTIs) are a microbial disease reported worldwide. Women are particularly susceptible with many suffering debilitating recurrent (r) infections. Read More

    Clinical, histological, and immunohistochemical markers of resistance to Methyl-aminolevulinate Photodynamic therapy in Bowen's disease.
    Br J Dermatol 2017 Sep 8. Epub 2017 Sep 8.
    Department of Dermatology. Hospital, San Jorge. Huesca, Spain.
    Bowen's disease (BD) is an intraepidermic squamous cell carcinoma (SCC), which principally appears on photoexposed areas.(1) Methyl-aminolevulinate (MAL) photodynamic therapy (PDT) is an excellent option for the treatment of BD (strength of recommendation, A; quality of evidence, 1). However, despite good response rates, some tumors prove non-responsive due to primary or acquired resistance. Read More

    A phase I trial of azacitidine and nanoparticle albumin bound paclitaxel in patients with advanced or metastatic solid tumors.
    Oncotarget 2017 Aug 26;8(32):52413-52419. Epub 2016 Dec 26.
    Department of Medicine, Division of Oncology, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT, USA.
    Background: Secreted protein acidic and rich in cysteine (SPARC), an albumin-binding protein, is downregulated by hypermethylation in many cancers. Hypomethylating agents such as azacitidine can upregulate SPARC in tumors, which may enhance the accumulation of albumin-bound drugs at tumor site. The objectives of this phase I trial was to determine the safety and maximum tolerated dose and to assess any clinical activity of the combination of azacytidine and weekly nanoparticle-albumin-bound (nab®) paclitaxel. Read More

    BRCA Genetic Testing and Receipt of Preventive Interventions Among Women Aged 18-64 Years with Employer-Sponsored Health Insurance in Nonmetropolitan and Metropolitan Areas - United States, 2009-2014.
    MMWR Surveill Summ 2017 Sep 8;66(15):1-11. Epub 2017 Sep 8.
    Office of Public Health Genomics, Division of Public Health Information Dissemination, Center for Surveillance, Epidemiology, and Laboratory Services, CDC, Atlanta, Georgia.
    Problem/condition: Genetic testing for breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) gene mutations can identify women at increased risk for breast and ovarian cancer. These testing results can be used to select preventive interventions and guide treatment. Differences between nonmetropolitan and metropolitan populations in rates of BRCA testing and receipt of preventive interventions after testing have not previously been examined. Read More

    Congenital heart disease: A primer for the pediatric neuropsychologist.
    Child Neuropsychol 2017 Sep 6:1-44. Epub 2017 Sep 6.
    h Department of Pediatrics , Children's Hospital Colorado, University of Colorado School of Medicine , Aurora , CO , USA.
    Congenital heart disease (CHD) affects millions of people worldwide, including over one million children in the United States. Approximately 25% of children born with CHD require intensive surgical intervention within the first year of life. Despite improved rates of survival into adulthood - rates that exceed 90% in the modern era - children and adolescents with CHD remain at risk for neurological injury and a range of neurobehavioral and psychosocial challenges that pose a threat to quality of life across the lifespan. Read More

    Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen-progestin therapy.
    Arch Physiol Biochem 2017 Sep 3:1-10. Epub 2017 Sep 3.
    a Cardiovascular Research Laboratory, Department of Physiology , University of Ilorin, Ilorin, Nigeria.
    Context: Cigarette smoking is considered to be a major risk factor for the development of diabetes and cardiovascular disease. Oestrogen-progestin combined oral contraceptive (COC) use has been associated with adverse cardiometabolic events.

    Objective: We hypothesized that nicotine would ameliorate insulin resistance (IR) that is accompanied by decreased cardiac glycogen synthase kinase-3 (GSK-3) and plasminogen activator inhibitor-1 (PAI-1). Read More

    Taking the defensive: Immune control of Zika virus infection.
    Virus Res 2017 Sep 1. Epub 2017 Sep 1.
    Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, 30322, USA; Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, 30329, USA; Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA. Electronic address:
    ZIKV is a neurotropic mosquito-borne flavivirus that has recently emerged in the Americas and is a pathogen of significant public health concern across the world. ZIKV was first isolated in Uganda in 1947 and remained dormant in Africa and Asia for decades, with sporadic outbreaks characterized by a mild self-limiting disease in humans. The emergence of ZIKV in the Americas corresponded with enhanced disease severity and congenital Zika syndrome, a phenotype characterized by severe microcephaly, brain anomalies, ocular anomalies, congenital contractures and neurological impairments. Read More

    Characterization of enamel caries lesions in rat molars using synchrotron X-ray microtomography.
    J Synchrotron Radiat 2017 Sep 18;24(Pt 5):1056-1064. Epub 2017 Aug 18.
    Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
    Dental caries is a ubiquitous infectious disease with a nearly 100% lifetime prevalence. Rodent caries models are widely used to investigate the etiology, progression and potential prevention or treatment of the disease. To explore the suitability of these models for deeper investigations of intact surface zones during enamel caries, the structures of early-stage carious lesions in rats were characterized and compared with previous reports on white spot enamel lesions in humans. Read More

    Shuttle walk tests in people with COPD who demonstrate exercise-induced oxygen desaturation: An analysis of test repeatability and cardiorespiratory responses.
    Chron Respir Dis 2017 Jan 1:1479972317729051. Epub 2017 Jan 1.
    1 Discipline of Physiotherapy, Faculty of Health Sciences, The University of Sydney, Lidcombe, New South Wales, Australia.
    Exercise-induced oxygen desaturation (EID) is prevalent in people with chronic obstructive pulmonary disease (COPD). This article reports a sub-analysis from a randomized controlled trial (RCT) in people with COPD and EID (COPD/EID). The primary aim, in people with COPD/ EID, was to determine the repeatability of the distance and time walked in the incremental shuttle walk test (ISWT) and endurance shuttle walk test (ESWT), respectively. Read More

    Preliminary Results of the Adoption and Application of the Integrated Comprehensive Care Bundle Care Program When Treating Patients with Chronic Obstructive Pulmonary Disease.
    Can Respir J 2017 7;2017:7049483. Epub 2017 Aug 7.
    Programs for Assessment of Technology in Health, The Research Institute of St. Joe's Hamilton, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
    Background: St. Joseph's Health System has implemented an integrated comprehensive care bundle care (ICC) program with the hopes that it would improve patients' care while reducing overall costs. The aim of this analysis was to evaluate the performance of the ICC program within patients admitted with chronic pulmonary obstructive disease (COPD). Read More

    The investigation of interferences in immunoassay.
    Clin Biochem 2017 Aug 26. Epub 2017 Aug 26.
    Department of Chemical Pathology, The Canberra Hospital, Canberra, ACT 2605, Australia; Australian National University Medical School, Canberra, ACT 2601, Australia.
    Immunoassay procedures have a wide application in clinical medicine and as such are used throughout clinical biochemistry laboratories both for urgent and routine testing. Clinicians and laboratory personnel are often presented with immunoassay results which are inconsistent with clinical findings. Without a high index of suspicion interferences will often not be suspected. Read More

    Subclonal Evolution of Cancer-Related Gene Mutations in p53 Immunopositive Patches in Human Skin.
    J Invest Dermatol 2017 Aug 24. Epub 2017 Aug 24.
    Dermatopharmacology, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, Hampshire, UK; Department of Dermatology, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, UK. Electronic address:
    Normal sun-exposed skin contains numerous epidermal patches that stain positive for p53 protein (p53 immunopositive patches, PIPs), which are considered potential early precursors of skin cancer. Although the TP53 gene is mutated in many PIPs, it is unclear whether PIPs contain any other cancer-related mutations. Here we report that PIPs, predominantly <3,000 p53 immunopositive cells in size, within normal chronically exposed skin contain mutations in multiple genes that are mutated in cutaneous squamous cell cancers. Read More

    Evaluation of the quality of life in patients with arsenic keratosis.
    Cutan Ocul Toxicol 2017 Aug 25:1-5. Epub 2017 Aug 25.
    f Department of Biology, Faculty of Arts and Science , Dumlupinar University , Kutahya , Turkey.
    Background: Chronic exposure to inorganic arsenic is an important public health problem and leads to hyperpigmentation, hyperkeratosis, Bowen's disease and non-melanoma skin cancers in humans. Arsenic keratosis is the most common skin change that is associated with arsenic exposure. It may be an indicator of arsenic induced health hazards. Read More

    Coupling gene-based and classic veterinary diagnostics improves interpretation of health and immune function in the Agassiz's desert tortoise (Gopherus agassizii).
    Conserv Physiol 2017 16;5(1):cox037. Epub 2017 Jun 16.
    US Geological Survey, Western Ecological Research Center, Las Vegas Field Station, 160 N. Stephanie Street, Henderson, NV 89074, USA.
    The analysis of blood constituents is a widely used tool to aid in monitoring of animal health and disease. However, classic blood diagnostics (i.e. Read More

    What's new in dermoscopy of Bowen's disease: two new dermoscopic signs and its differential diagnosis.
    Int J Dermatol 2017 Oct 22;56(10):1022-1025. Epub 2017 Aug 22.
    Department of Dermatology, the 1st Affiliated Hospital of Dalian Medical University, Dalian, China.
    Background: Clinical and dermoscopic features of Bowen's disease (BD) show great diversity. Some lesions of BD are often difficult to be differentiated from seborrheic keratosis, actinic keratosis, lichen planus-like keratosis, etc. It is necessary to fully describe the dermoscopic features of the disease, considering differential diagnosis. Read More

    A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product.
    BMC Public Health 2017 Aug 22;17(1):673. Epub 2017 Aug 22.
    British American Tobacco (Investments) Limited, Research and Development, Regents Park Road, Southampton, SO15 8TL, UK.
    Background: Smoking is a leading cause of numerous human disorders including lung cancer, chronic obstructive pulmonary disease, and atherosclerotic cardiovascular disease. The development of modified risk tobacco products (MRTPs) has been suggested as a possible way to reduce the risks of tobacco smoking by reducing exposure to cigarette smoke toxicants. This study is designed to investigate whether biomarkers of such exposure are reduced when smokers switch from smoking commercial cigarettes to using either a novel or a commercially-available tobacco heating product (THP). Read More

    Adult Orbital and Adnexal Xanthogranulomatous Disease.
    Asia Pac J Ophthalmol (Phila) 2017 Sep-Oct;6(5):435-443. Epub 2017 Aug 22.
    Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
    Purpose: Adult xanthogranulomatous disease of the orbit and ocular adnexa is a rare disease that can cause serious morbidity and mortality. Ophthalmologists are commonly the first clinicians to come in contact with affected patients and an understanding of the clinical features is essential.

    Design: We present a retrospective case series of patients seen in the oculoplastic unit of a large tertiary referral hospital over a 20-year period. Read More

    MicroRNAs as biomarkers in chronic kidney disease.
    Curr Opin Nephrol Hypertens 2017 Nov;26(6):460-466
    Wales Kidney Research Unit, School of Medicine, University Hospital Wales, Cardiff University, Cardiff, UK.
    Purpose Of Review: This review summarizes recent data supporting the concept that urinary microRNAs are a useful new class of biomarker. They may improve capacity to stratify patients with chronic kidney disease according to risk of progression, and may also inform about response to therapy.

    Recent Findings: MicroRNAs are present, stable and readily quantifiable in tissues and body fluids, including urine, and have widespread importance as regulators in the kidney. Read More

    The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission.
    Tuberculosis (Edinb) 2017 Sep 14;106:91-98. Epub 2017 Jul 14.
    Department of Microbiology, Immunology and Pathology, Colorado State University, Campus Delivery 1682, Fort Collins, CO 80523, USA. Electronic address:
    In endemic countries more than 20% of tuberculosis (TB) cases are in infants and children. Current animal models study TB during adulthood but animal models for infant TB are scarce. Here we propose that minipigs can be used as an animal model to study adult, adolescent and infant TB including natural transmission. Read More

    1 OF 86