4,521 results match your criteria Bowen Disease


Comparison of HSV-1 strains circulating in Finland demonstrates the uncoupling of whole-genome relatedness and phenotypic outcomes of viral infection.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA

A majority of adults in Finland are seropositive carriers of herpes simplex viruses (HSV). Infection occurs at epithelial or mucosal surfaces, after which virions enter innervating nerve endings, eventually establishing lifelong infection in neurons of the sensory or autonomic nervous system. Recent data have highlighted the genetic diversity of HSV-1 strains, and demonstrated apparent geographic patterns in strain similarity. Read More

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http://dx.doi.org/10.1128/JVI.01824-18DOI Listing
February 2019

Multi-Year Evaluation of Commercial Soybean Cultivars for Resistance to Phytophthora sojae.

Plant Dis 2010 Mar;94(3):368-371

USDA-ARS and Department of Crop Sciences, University of Illinois, Urbana 61801.

Phytophthora sojae causes damping-off, root rot, and stem rot of soybean, particularly in poorly drained soils. Soybean cultivar resistance is one of the primary methods to control this disease, with Rps1c, Rps1k, and Rps1a being the most commonly used genes. The Varietal Information Program for Soybeans (VIPS) at the University of Illinois evaluates soybean cultivars for resistance to a number of diseases including Phytophthora root rot (PRR). Read More

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http://dx.doi.org/10.1094/PDIS-94-3-0368DOI Listing

Evidence for Household Transmission of Rotavirus in the United States, 2011-2016.

J Pediatric Infect Dis Soc 2019 Feb 7. Epub 2019 Feb 7.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Rotavirus is a leading cause of acute gastroenteritis (AGE) in children and is highly transmissible. In this study, we assessed the presence of AGE in household contacts (HHCs) of pediatric patients with laboratory-confirmed rotavirus.

Methods: Between December 2011 and June 2016, children aged 14 days to 11 years with AGE were enrolled at 1 of 7 hospitals or emergency departments as part of the New Vaccine Surveillance Network. Read More

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http://dx.doi.org/10.1093/jpids/piz004DOI Listing
February 2019

Development of FamilyTalk: an Intervention to Support Communication and Educate Families About Colorectal Cancer Risk.

J Cancer Educ 2019 Feb 9. Epub 2019 Feb 9.

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.

IFamily members of individuals with colorectal cancer (CRC) may be at increased risk of developing the disease. However, the majority of CRC can be prevented through colonoscopy screening and family members may not be aware if they are recommended to pursue earlier screening because of their family history of CRC. As such, tools must be developed to effectively communicate potential changes to the recommended age for colonoscopy screening and other important CRC-related information to family members. Read More

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http://dx.doi.org/10.1007/s13187-019-1484-3DOI Listing
February 2019
1 Read

Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model.

Chemotherapy 2019 Feb 7;63(5):284-292. Epub 2019 Feb 7.

Discipline of Physiology, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Background: The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered efforts to deliver effective supportive care interventions, particularly for gastrointestinal (GI) toxicity. Matrix metalloproteinases (MMPs) have been implicated in both tumor growth and GI toxicity, and as such MMP inhibitors present as a novel therapeutic avenue to simultaneously enhance treatment efficacy and reduce toxicity.

Objectives: The aim of this study was to determine the efficacy of an MMP-9/12 inhibitor, AZD3342, on tumor growth and GI toxicity in a rat model. Read More

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http://dx.doi.org/10.1159/000495470DOI Listing
February 2019
1 Read

Bowen Disease with Invasive Mucin-Secreting Sweat Gland Differentiation: Report of a Case and Review of the Literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Central Zone (Halifax), NS,, Canada.

Bowen Disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. Read More

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http://dx.doi.org/10.1111/cup.13437DOI Listing
February 2019
1 Read

The causes of nail apparatus pigmentation presenting to a melanoma screening clinic a prospective study.

Clin Exp Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Dermatology Unit, Royal Victoria Infirmary, Newcastle Upon Tyne, UK.

Background: Advanced stage primary cutaneous malignant melanoma (PCMM) has a high mortality. PCMM may affect any area of the skin, including the nail apparatus (malignant melanoma or subungual melanoma). Although nail apparatus malignant melanoma (NAMM) is rare, delayed diagnosis carries a poor prognosis. Read More

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http://doi.wiley.com/10.1111/ced.13897
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http://dx.doi.org/10.1111/ced.13897DOI Listing
January 2019
1 Read

Long-term efficacy of photodynamic therapy with methyl aminolevulinate in treating Bowen's disease in clinical practice: a retrospective cohort study (2006-2017).

Photodermatol Photoimmunol Photomed 2019 Jan 28. Epub 2019 Jan 28.

Departments of Dermatology, Statistics. Hospital Costa del Sol. Marbella, Spain.

Background: Photodynamic treatment with methyl aminolevulinate (MAL-PDT) is considered an effective and highly recommended treatment for Bowen's disease. However, its long-term efficacy remains to be established, as significant differences have been reported in this respect.

Objective: The aim of the present study is to describe the results of a retrospective analysis of patients with Bowen's disease treated with MAL-PDT during the period 2006-17 at the Costa del Sol Hospital (Marbella, Spain). Read More

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http://dx.doi.org/10.1111/phpp.12453DOI Listing
January 2019

Mast Cells Are a Marked Source for Complement C3 Products That Associate with Increased CD11b-Positive Cells in Keratinocyte Skin Carcinomas.

Cancer Invest 2019 Jan 28:1-12. Epub 2019 Jan 28.

a Department of Dermatology , Kuopio University Hospital, University of Eastern Finland , Kuopio , Finland.

By using immunohistochemistry and antibodies that identify complement C3c (in C3 and C3b) or CD11b receptor, we report that the proportion C3c mast cells and the number of CD11b cells are increased in basal cell carcinoma (BCC). Instead, only CD11b cells are increased in squamous cell carcinoma/Bowen's disease, and only slightly so in actinic keratosis. Only C3c mast cells are increased in psoriasis. Read More

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http://dx.doi.org/10.1080/07357907.2019.1565765DOI Listing
January 2019
1 Read

Septal hypertrophy and cell cycle re-entry in AD.

Aging (Albany NY) 2019 Jan;11(2):297-298

Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53705, USA.

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http://dx.doi.org/10.18632/aging.101777DOI Listing
January 2019

[Repair of skin and soft tissue defects of auricle and donor site with relay flap].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Jan;33(1):66-69

Department of Burn Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, 563003, P.R.China.

Objective: To investigate the effectiveness of relay flap on repairing skin and soft tissue defect of auricle and donor site.

Methods: Between May 2014 and January 2016, 10 patients with auricular tumor were repaired by relay flap. There were 4 males and 6 females with an average age of 35 years (range, 21-69 years). Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201807141
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http://dx.doi.org/10.7507/1002-1892.201807141DOI Listing
January 2019
5 Reads

A Case Series of Bowen's Disease Treated with the Combination of Cryosurgery and Ingenol Mebutate and Followed Up with Optical Coherence Tomography.

Case Rep Dermatol Med 2018 16;2018:9423949. Epub 2018 Dec 16.

Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Bowen's disease (BD) is a relatively rare squamous cell carcinoma (SCC) with a limited potential of becoming invasive. Ingenol mebutate (IM) was relatively successful for the treatment of BD lesions in small case series. Optical coherence tomography (OCT) is a promising method for the diagnosis of cutaneous keratinocytic carcinomas, including BD. Read More

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http://dx.doi.org/10.1155/2018/9423949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311265PMC
December 2018

Mumps outbreaks in ethnic subpopulations: what can we learn?

Lancet Infect Dis 2019 Feb 8;19(2):119-120. Epub 2019 Jan 8.

Wesfarmer's Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA 6009, Australia; Department of Infectious Diseases, Perth Children's Hospital, Nedlands WA 6009, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S14733099183065
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http://dx.doi.org/10.1016/S1473-3099(18)30652-2DOI Listing
February 2019
7 Reads

Regression Analysis of Protoporphyrin IX Measurements Obtained During Dermatological Photodynamic Therapy.

Cancers (Basel) 2019 Jan 10;11(1). Epub 2019 Jan 10.

European Centre for Environment and Human Health, University of Exeter Medical School, University of Exeter, Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall TR1 3HD, UK.

Photodynamic therapy (PDT) is a light activated drug therapy that can be used to treat a number of dermatological cancers and precancers. Improvement of efficacy is required to widen its application. Clinical protoporphyrin IX (PpIX) fluorescence data were obtained using a pre-validated, non-invasive imaging system during routine methyl aminolevulinate (MAL)-PDT treatment of 172 patients with licensed dermatological indications (37. Read More

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http://www.mdpi.com/2072-6694/11/1/72
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http://dx.doi.org/10.3390/cancers11010072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356372PMC
January 2019
7 Reads

Genome-wide discovery of somatic coding and non-coding mutations in pediatric endemic and sporadic Burkitt lymphoma.

Blood 2019 Jan 7. Epub 2019 Jan 7.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, United States.

Though generally curable with intensive chemotherapy in resource-rich settings, Burkitt lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa. Epstein-Barr virus (EBV) positivity is a feature in over 90% of cases in malaria-endemic regions and up to 30% elsewhere. However, the molecular features of BL have not been comprehensively evaluated when taking into account tumor EBV status or geographic origin. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-09
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http://dx.doi.org/10.1182/blood-2018-09-871418DOI Listing
January 2019
21 Reads
10.452 Impact Factor

Squamous Cell Carcinoma in Perineal, Perianal, and Gluteal Hidradenitis Suppurativa: Experience in 12 Patients.

Dermatol Surg 2018 Dec 24. Epub 2018 Dec 24.

Departments of Dermatology.

Background: Few reports describe squamous cell carcinoma (SCC) arising in hidradenitis suppurativa (HS).

Objective: The 2 objectives were (1) to describe the clinical characteristics, pathologic findings, and postoperative outcomes of SCC in HS and (2) to assess whether human papillomavirus (HPV) is involved in the pathogenesis.

Materials And Methods: Cases of SCC in HS were identified through institutional medical records (1976-2013) and the Rochester Epidemiology Project. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001713DOI Listing
December 2018
2 Reads

Successful Use of Quality Improvement Methodology to Reduce Inpatient Length of Stay in Bronchiolitis Through Judicious Use of Intermittent Pulse Oximetry.

Hosp Pediatr 2019 Feb 3;9(2):73-78. Epub 2019 Jan 3.

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background And Objectives: The American Academy of Pediatrics 2014 bronchiolitis guidelines recommend against the routine use of continuous pulse oximetry (CPO) because it has been implicated in prolonging the length of stay (LOS). At our institution, infants admitted with bronchiolitis were monitored by using CPO during the entire hospital stay and intermittent desaturations <90% appeared to delay discharge. This quality improvement initiative was designed to reduce the LOS by decreasing the use of CPO in stable infants with nonsevere bronchiolitis. Read More

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http://dx.doi.org/10.1542/hpeds.2018-0023DOI Listing
February 2019
4 Reads

Germ line TP53 mutation in a patient with multiple Bowen's disease.

J Dermatol 2018 Dec 28. Epub 2018 Dec 28.

Department of Dermatology, Toyama Prefectural Central Hospital, Toyama, Japan.

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http://dx.doi.org/10.1111/1346-8138.14744DOI Listing
December 2018
5 Reads

De novo malignancy in heart transplant recipients: A single center experience in Japan.

J Cardiol 2018 Dec 22. Epub 2018 Dec 22.

Department of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan. Electronic address:

Background: Because of aggressive immunosuppression, heart transplant recipients have a high risk of de novo malignancy, which is a major cause of death and worse prognosis, regardless of the type. However, the impact of de novo malignancy on Japanese heart transplant recipients is unknown.

Methods: We analyzed 103 Japanese heart transplant recipients over 18-years-old at the time of transplantation between April 1999 and April 2017. Read More

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http://dx.doi.org/10.1016/j.jjcc.2018.11.011DOI Listing
December 2018
2 Reads

Dermatoscopic findings of penile intraepithelial neoplasia: Bowenoid papulosis, Bowen disease and erythroplasia of Queyrat.

Australas J Dermatol 2018 Dec 25. Epub 2018 Dec 25.

Department of Dermatology, University College London Hospital, London, UK.

Background/objectives: The clinical diagnosis of penile intraepithelial neoplasia is challenging. No specific dermoscopic criteria for penile intraepithelial neoplasia have been described in the literature. This study aimed to describe and evaluate the dermoscopic features of penile intraepithelial neoplasia. Read More

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http://dx.doi.org/10.1111/ajd.12981DOI Listing
December 2018
7 Reads

Treatment, prevention and public health management of impetigo, scabies, crusted scabies and fungal skin infections in endemic populations: a systematic review.

Trop Med Int Health 2018 Dec 24. Epub 2018 Dec 24.

Menzies School of Health Research, Charles Darwin University, Casuarina, Australia.

We conducted a systematic review of the treatment, prevention and public health control of skin infections including impetigo, scabies, crusted scabies and tinea in resource-limited settings where skin infections are endemic. The aim is to inform strategies, guidelines and research to improve skin health in populations that are inequitably affected by infections of the skin and the downstream consequences of these. The systematic review is reported according to the PRISMA statement. Read More

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http://doi.wiley.com/10.1111/tmi.13198
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http://dx.doi.org/10.1111/tmi.13198DOI Listing
December 2018
14 Reads

A real-world comparison of relapse rates, healthcare costs and resource use among patients with multiple sclerosis newly initiating subcutaneous interferon beta-1a versus oral disease-modifying drugs.

Mult Scler J Exp Transl Clin 2018 Oct-Dec;4(4):2055217318819031. Epub 2018 Dec 17.

Health Economics & Outcomes Research, EMD Serono, Inc., USA.

Background: Administrative-claims data enable comparative effectiveness assessment using large numbers of patients treated in real-world settings.

Objective: To evaluate real-world relapses, healthcare costs and resource use in patients with MS newly initiating subcutaneous interferon beta-1a (sc IFNβ-1a) v. oral disease-modifying drugs (DMDs: dimethyl fumarate, fingolimod, teriflunomide). Read More

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http://dx.doi.org/10.1177/2055217318819031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299291PMC
December 2018

Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[]oxazol-2(3)-one (SN79) Derivatives.

J Pharmacol Exp Ther 2019 Feb 7;368(2):272-281. Epub 2018 Dec 7.

Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island (H.E.N., A.B.C., W.D.B.); Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, Mississippi (W.F.A., C.M., C.R.M.); and Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida (S.I., M.M., C.R.M.)

Sigma-2 receptors, recently identified as TMEM97, have been implicated in cancer and neurodegenerative disease. Structurally distinct sigma-2 receptor ligands induce cell death in tumor cells, linking sigma-2 receptors to apoptotic pathways. Recently, we reported that sigma-2 receptors can also stimulate glycolytic hallmarks, effects consistent with a prosurvival function and upregulation in cancer cells. Read More

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http://dx.doi.org/10.1124/jpet.118.253484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346378PMC
February 2019
2 Reads

Multimorbidity rehabilitation versus disease-specific rehabilitation in people with chronic diseases: a pilot randomized controlled trial.

Pilot Feasibility Stud 2018 29;4:181. Epub 2018 Nov 29.

1Department of Physiotherapy/Community Services, Western Health, 176 Furlong Road, St Albans, Victoria 3021 Australia.

Background: Multimorbidity (the co-existence of two or more chronic conditions in an individual) is a growing healthcare burden internationally; however, healthcare and disease management, including rehabilitation, is often delivered in single-disease siloes. The aims of this study were to (1) evaluate the safety and feasibility of multimorbidity rehabilitation compared to a disease-specific rehabilitation program in people with multimorbidity and (2) gather preliminary data regarding clinical outcomes and resource utilization to inform the design of future trials.

Methods: A pilot feasibility randomized controlled trial with concealed allocation, assessor blinding, and intention-to-treat analysis. Read More

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http://dx.doi.org/10.1186/s40814-018-0369-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267787PMC
November 2018
1 Read

Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands.

Int J Urol 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, University Medical Center Utrecht, Utrecht, the Netherlands.

Objective: To determine the incidence of penile intraepithelial neoplasia in the Netherlands using a nationwide histopathology registry and to discuss the nomenclature of premalignant penile lesions.

Methods: Data from patients in the Netherlands diagnosed with a premalignant penile lesion between January 1998 and December 2007 were collected from the nationwide histopathology registry (PALGA); this database covers all pathology reports of inhabitants in the Netherlands. The premalignant lesions included were erythroplasia of Queyrat; Bowen's disease; bowenoid papulosis; mild, moderate and severe dysplasia; and carcinoma in situ of the penis. Read More

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http://dx.doi.org/10.1111/iju.13871DOI Listing
December 2018
6 Reads

Acral and Multicentric Pigmented Bowen's Disease in HIV-Positive Patients: Report on Two Unusual Cases.

Indian J Dermatol 2018 Nov-Dec;63(6):506-508

Centro De Investigación En Enfermedades Infecciosas, Instituto Nacional De Enfermedades Respiratorias, Ismael Cosío Villegas, México City, México.

squamous cell carcinoma of the skin (SCCis or Bowen's disease) is a common intraepidermal cutaneous malignancy with a low invasive potential. Acral Bowen's disease is usually solitary, but multiple acral SCCis have been reported. Pigmented Bowen's disease is typically unilesional and characterized by a hyperpigmented plaque with a velvety of keratotic surface, which can eventually simulate melanoma clinically. Read More

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http://dx.doi.org/10.4103/ijd.IJD_47_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233036PMC
December 2018
3 Reads

Actinic keratosis and squamous cell carcinoma of the elderly

Rev Prat 2017 12;67(10):1084-1088

Service de gériatrie - plaies et cicatrisation, hôpital Rothschild, Assistance publique-Hôpitaux de Paris, Paris, France.

Actinic keratosis and squamous cell carcinoma in the elderly. The increase in life expectancy and the change in the habits of the population with respect to UV exposure have led to an increase in the incidence of actinic keratosis (AK) and squamous cell carcinoma (SCC). There is no specific recommendation for the "frail" elderly, but they would not differ much from the recommendations of the younger subjects. Read More

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December 2017
8 Reads

Neurodevelopmental outcomes of extremely preterm infants in New South Wales and the Australian Capital Territory.

J Paediatr Child Health 2018 Nov 30. Epub 2018 Nov 30.

Department of Newborn Care, Royal Hospital for Women, Sydney, New South Wales, Australia.

Aim: This study aimed to provide updated information on gestation-specific neurodevelopmental outcomes of extremely to very preterm infants 23-28 weeks' gestation admitted to neonatal intensive care units (NICUs).

Methods: This was a population-based retrospective cohort study of infants born between 23 and 28 weeks' gestation and admitted to a network of NICUs between 2007 and 2012 in a well-defined geographic area of New South Wales (NSW) and the Australian Capital Territory (ACT). Primary outcome was moderate to severe neurodevelopmental impairment. Read More

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http://dx.doi.org/10.1111/jpc.14323DOI Listing
November 2018
1 Read

Management factors and clinical implications of glandular and squamous gastric disease in horses.

J Vet Intern Med 2019 Jan 29;33(1):233-240. Epub 2018 Nov 29.

School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom.

Background: To date, risk factors for equine glandular gastric disease (EGGD) have not been described in Thoroughbred racehorses.

Objectives: To determine management factors associated with EGGD, identify clinical signs in affected horses, and compare these to equine squamous gastric disease (ESGD).

Animals: The study was carried out on 109 Thoroughbred racehorses from 8 training yards (3 in the United Kingdom and 5 in Australia). Read More

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http://dx.doi.org/10.1111/jvim.15350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335573PMC
January 2019
1 Read

Identification of expressed R-genes associated with leaf spot diseases in cultivated peanut.

Mol Biol Rep 2018 Nov 30. Epub 2018 Nov 30.

Department of Crop, Soil and Environmental Sciences, Auburn University, 258 Funchess Hall, Auburn, AL, 36849, USA.

Peanut (Arachis hypogaea L.) is an important food and oilseed crop worldwide. Yield and quality can be significantly reduced by foliar fungal diseases, such as early and late leaf spot diseases. Read More

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http://dx.doi.org/10.1007/s11033-018-4464-5DOI Listing
November 2018

Aggressive nutrition intervention reduces ascites and frequency of paracentesis in malnourished patients with cirrhosis and ascites.

JGH Open 2017 Nov 31;1(3):92-97. Epub 2017 Oct 31.

Liver Injury and Cancer Centenary Research Institute Sydney New South Wales Australia.

Background And Aim: Alterations in nutrient metabolism, nutritional requirements, and reduced dietary intakes are common in chronic liver disease (CLD). These result in malnutrition, sarcopenia, and exacerbate progression to decompensation and ascites. We aimed to investigate the effects of continuous tube feeding (TF) on nutritional status and levels of ascites in malnourished individuals with decompensated cirrhosis. Read More

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http://dx.doi.org/10.1002/jgh3.12016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206992PMC
November 2017
1 Read

Toll-like receptor/interleukin-1 domain innate immune signalling pathway genetic variants are candidate predictors for severe gastrointestinal toxicity risk following 5-fluorouracil-based chemotherapy.

Cancer Chemother Pharmacol 2018 Nov 24. Epub 2018 Nov 24.

Cancer Treatment Toxicities Group, Adelaide Medical School, Disciplines of Pharmacology and Physiology, University of Adelaide, Level 2, Helen Mayo South Building, Adelaide, SA, 5005, Australia.

Purpose: Severe gastrointestinal (GI) toxicity is a common adverse effect following 5-fluorouracil (5-FU)-based chemotherapy treatment. The presence of severe GI toxicity leads to treatment revisions, sub-optimal therapy outcomes, and decreases to patients' quality of life. There are no adequate predictors for 5-FU-induced severe GI toxicity risk. Read More

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http://dx.doi.org/10.1007/s00280-018-3729-yDOI Listing
November 2018
6 Reads

Model-Based and Model-Free Techniques for Amyotrophic Lateral Sclerosis Diagnostic Prediction and Patient Clustering.

Neuroinformatics 2018 Nov 20. Epub 2018 Nov 20.

Statistics Online Computational Resource, Department of Health Behavior and Biological Sciences, University of Michigan, Ann Arbor, MI, 48109, USA.

Amyotrophic lateral sclerosis (ALS) is a complex progressive neurodegenerative disorder with an estimated prevalence of about 5 per 100,000 people in the United States. In this study, the ALS disease progression is measured by the change of Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) score over time. The study aims to provide clinical decision support for timely forecasting of the ALS trajectory as well as accurate and reproducible computable phenotypic clustering of participants. Read More

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http://dx.doi.org/10.1007/s12021-018-9406-9DOI Listing
November 2018
10 Reads

Hepatitis B virus infection among sexually active individuals in Nigeria: a cross-sectional study.

Pan Afr Med J 2018 20;30:155. Epub 2018 Jun 20.

Department of Virology, College of Medicine University of Ibadan, Nigeria.

Introduction: Hepatitis B virus (HBV) infection is a major health challenge in sub-Saharan African countries. Chronic HBV infection is a risk factor for severe disease progression. Perinatal and sexual transmissions of Hepatitis B virus are the main routes of infection in HBV endemic countries like Nigeria. Read More

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http://www.panafrican-med-journal.com/content/article/30/155
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http://dx.doi.org/10.11604/pamj.2018.30.155.14886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235487PMC
December 2018
6 Reads

The Cancer Prevention Project of Philadelphia: preliminary findings examining diversity among the African diaspora.

Ethn Health 2018 Nov 19:1-17. Epub 2018 Nov 19.

a Cancer Prevention and Control Program , Fox Chase Cancer Center-Temple Health , Philadelphia , USA.

Objective: Cancer mortality inequity among persons of African Ancestry is remarkable. Yet, Black inclusion in cancer biology research is sorely lacking and warrants urgent attention. Epidemiologic research linking African Ancestry and the African Diaspora to disease susceptibility and outcomes is critical for understanding the significant and troubling health disparities among Blacks. Read More

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https://www.tandfonline.com/doi/full/10.1080/13557858.2018.1
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http://dx.doi.org/10.1080/13557858.2018.1548695DOI Listing
November 2018
10 Reads

Neutropenia in Barth syndrome: characteristics, risks, and management.

Curr Opin Hematol 2019 Jan;26(1):6-15

Department of Medicine, University of Washington, Seattle, Washington, USA.

Purpose Of Review: Barth syndrome (BTHS) is an X-linked disease characterized by defective remodeling of phospholipid side chains in mitochondrial membranes. Major features include neutropenia, dilated cardiomyopathy, motor delay and proximal myopathy, feeding problems, and constitutional growth delay. We conducted this review of neutropenia in BTHS to aid in the diagnosis of this disease, and to improve understanding of both the consequences of neutropenia and the benefits of treatment with granulocyte colony-stimulating factor (G-CSF). Read More

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http://dx.doi.org/10.1097/MOH.0000000000000472DOI Listing
January 2019
14 Reads

Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease.

Alzheimers Dement (Amst) 2018 22;10:595-598. Epub 2018 Sep 22.

NHLBI's Framingham Heart Study, Framingham, MA, USA.

Introduction: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein () locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C. Read More

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http://dx.doi.org/10.1016/j.dadm.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215982PMC
September 2018
11 Reads

Proportion of Violent Injuries Unreported to Law Enforcement.

JAMA Intern Med 2018 Nov 12. Epub 2018 Nov 12.

Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia.

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http://dx.doi.org/10.1001/jamainternmed.2018.5139DOI Listing
November 2018
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Multicentric Anogenital Bowen's Disease Treated with Imiquimod and CO Laser.

Skinmed 2018 9;16(5):333-335. Epub 2018 Nov 9.

Department of Dermatology, University of Tunis El Manar, Tunis, Tunisia.

A 53-year-old white woman presented to our clinic with skin lesions in the anogenital region that had persisted for 1 year. She had a past medical history of total vulvectomy for a vulvar localization of Bowen's disease. She was otherwise in good health, with no evidence of illness or immunosuppression. Read More

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November 2018
6 Reads

On "Multicentric Anogenital Bowen's Disease Treated with Imiquimod and CO Laser".

Skinmed 2018 9;16(5):299-300. Epub 2018 Nov 9.

Department of Dermatology, Rutgers - New Jersey Medical School, Newark, NJ.

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November 2018
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Automated CT Perfusion Prediction of Large Vessel Acute Stroke from Intracranial Atherosclerotic Disease.

Interv Neurol 2018 Oct 17;7(6):334-340. Epub 2018 May 17.

Emory University/Grady Memorial Hospital - Marcus Stroke and Neuroscience Center, Atlanta, Georgia, USA.

Background And Purpose: We have observed that large vessel occlusion acute strokes (LVOS) due to intracranial atherosclerotic disease (ICAD) present with more benign CT perfusion (CTP) profiles, which we presume to potentially represent enhanced collateralization compared to embolic LVOS. We aim to determine if CTP profiles can predict ICAD in LVOS.

Methods: Retrospective review of a prospectively collected interventional stroke database from September 2010 to March 2015. Read More

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https://www.karger.com/Article/FullText/487335
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http://dx.doi.org/10.1159/000487335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216702PMC
October 2018
9 Reads

Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease.

Noncoding RNA 2018 Nov 3;4(4). Epub 2018 Nov 3.

Wales Kidney Research Unit, Division of Infection and Immunity, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4XN, UK.

The kidneys play key roles in the maintenance of homeostasis, including fluid balance, blood filtration, erythropoiesis and hormone production. Disease-driven perturbation of renal function therefore has profound pathological effects, and chronic kidney disease is a leading cause of morbidity and mortality worldwide. Successive annual increases in global chronic kidney disease patient numbers in part reflect upward trends for predisposing factors, including diabetes, obesity, hypertension, cardiovascular disease and population age. Read More

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http://www.mdpi.com/2311-553X/4/4/30
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http://dx.doi.org/10.3390/ncrna4040030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315559PMC
November 2018
9 Reads

Dermatological conditions seen in renal transplant recipients in a Singapore tertiary hospital.

Singapore Med J 2018 Oct;59(10):519-523

Department of Dermatology, Singapore General Hospital, Singapore.

Introduction: Lifelong immunosuppression after renal transplant exerts effects on the recipients' skin, including skin infections, skin cancers and drug-induced skin disorders. Our study aimed to determine the epidemiology of skin conditions among renal transplant recipients in the largest tertiary hospital in Singapore.

Methods: We reviewed the medical records of kidney transplant recipients at Singapore General Hospital, Singapore, between 1 January 2003 and 31 December 2013. Read More

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http://dx.doi.org/10.11622/smedj.2018126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199188PMC
October 2018
10 Reads

International consensus on quality standards for brain health-focused care in multiple sclerosis.

Mult Scler 2018 Nov 1:1352458518809326. Epub 2018 Nov 1.

Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK.

Background:: Time matters in multiple sclerosis (MS). Irreversible neural damage and cell loss occur from disease onset. The MS community has endorsed a management strategy of prompt diagnosis, timely intervention and regular proactive monitoring of treatment effectiveness and disease activity to improve outcomes in people with MS. Read More

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http://dx.doi.org/10.1177/1352458518809326DOI Listing
November 2018
3 Reads

Hypomelanotic melanoma simulating pigmented Bowen's disease and its challenging dermoscopic features.

J Dermatol 2018 Oct 24. Epub 2018 Oct 24.

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1111/1346-8138.14687DOI Listing
October 2018

Impaired osteocyte maturation in the pathogenesis of renal osteodystrophy.

Kidney Int 2018 Nov;94(5):1002-1012

Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. Electronic address:

Pediatric renal osteodystrophy is characterized by skeletal mineralization defects, but the role of osteoblast and osteocyte maturation in the pathogenesis of these defects is unknown. We evaluated markers of osteocyte maturation and programmed cell death in iliac crest biopsy samples from pediatric dialysis patients and healthy controls. We evaluated the relationship between numbers of fibroblast growth factor 23 (FGF23)-expressing osteocytes and histomorphometric parameters of skeletal mineralization. Read More

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http://dx.doi.org/10.1016/j.kint.2018.08.011DOI Listing
November 2018
2 Reads

Prevalence, impact and specialised treatment of urinary incontinence in women with chronic lung disease.

Physiotherapy 2019 03 30;105(1):114-119. Epub 2018 Jul 30.

Physiotherapy Department, The Alfred Hospital, Melbourne, Victoria, Australia; La Trobe/Alfred Health Clinical School, Melbourne, Victoria, Australia; Institute for Breathing and Sleep, Bowen Centre, Austin Hospital, Heidelberg, Victoria, Australia.

Objectives: To determine in women with clinically stable chronic lung disease (CLD) and healthy women; (1) prevalence of urinary incontinence; (2) risk factors for urinary incontinence; (3) effects of a standard course of specialised physiotherapy treatment (PT) in women with CLD.

Design: Prospective prevalence study; PT study in CLD subgroup.

Setting: Tertiary metropolitan public hospital. Read More

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http://dx.doi.org/10.1016/j.physio.2018.07.006DOI Listing
March 2019
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Housing: A Case for The Medicalization of Poverty.

J Law Med Ethics 2018 Sep;46(3):588-594

B. Cameron Webb, M.D., J.D., is an Assistant Professor in the University of Virginia School of Medicine, where he is the Director of Health Policy and Equity for the Department of Public Health Sciences and a Hospitalist in the Department of Medicine. Dayna Bowen Matthew, J.D., Ph.D., is the William L. Matheson and Robert M. Morgenthau Distinguished Professor of Law and the F. Palmer Weber Research Professor of Civil Liberties and Human Rights at the University of Virginia School of Law. She holds an appointment in the School of Medicine's Department of Public Health Sciences.

"Medicalization" has been a contentious notion since its introduction centuries ago. While some scholars lamented a medical overreach into social domains, others hailed its promise for social justice advocacy. Against the backdrop of a growing commitment to health equity across the nation, this article reviews historical interpretations of medicalization, offers an application of the term to non-biologic risk factors for disease, and presents the case of housing the demonstrate the great potential of medicalizing poverty. Read More

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http://journals.sagepub.com/doi/10.1177/1073110518804201
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http://dx.doi.org/10.1177/1073110518804201DOI Listing
September 2018
8 Reads