4,816 results match your criteria Bowen Disease


Retrospective clinical trial experimentally validates glioblastoma genome-wide pattern of DNA copy-number alterations predictor of survival.

APL Bioeng 2020 Jun 15;4(2):026106. Epub 2020 May 15.

Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

Modeling of genomic profiles from the Cancer Genome Atlas (TCGA) by using recently developed mathematical frameworks has associated a genome-wide pattern of DNA copy-number alterations with a shorter, roughly one-year, median survival time in glioblastoma (GBM) patients. Here, to experimentally test this relationship, we whole-genome sequenced DNA from tumor samples of patients. We show that the patients represent the U. Read More

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http://dx.doi.org/10.1063/1.5142559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229984PMC

Mobile Phone Use in the Management of Diabetes in Nigeria: A New Potential Weapon.

West Afr J Med 2020 Jul-Aug;37(3):201-208

Department of Medicine, Endocrinology, Diabetes & Metabolism Unit, Enugu State University of Science and Technology, Enugu, Enugu State, Nigeria.

Diabetes Mellitus (DM) is one of the leading chronic diseases in low- and middle-income countries globally including Nigeria The morbidities and mortalities associated with diabetes especially in Nigeria, have remained unacceptably high compared to many other nations. It has become one of the leading causes of stroke, blindness, heart attack and end-stage kidney disease. Most deaths occur in those below 60 years of age, the productive segments of the population. Read More

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Pathogen reduction of SARS-CoV-2 virus in plasma and whole blood using riboflavin and UV light.

PLoS One 2020 29;15(5):e0233947. Epub 2020 May 29.

Infectious Disease Research Center, Colorado State University, Fort Collins, Colorado, United States of America.

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has recently been identified as the causative agent for Coronavirus Disease 2019 (COVID-19). The ability of this agent to be transmitted by blood transfusion has not been documented, although viral RNA has been detected in serum. Exposure to treatment with riboflavin and ultraviolet light (R + UV) reduces blood-borne pathogens while maintaining blood product quality. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233947PLOS

Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.

Brain 2020 May 28. Epub 2020 May 28.

Departments of Physiology and Cell Biology, Brain and Cognitive Sciences, The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Repetitive mild traumatic brain injury in American football players has garnered increasing public attention following reports of chronic traumatic encephalopathy, a progressive tauopathy. While the mechanisms underlying repetitive mild traumatic brain injury-induced neurodegeneration are unknown and antemortem diagnostic tests are not available, neuropathology studies suggest a pathogenic role for microvascular injury, specifically blood-brain barrier dysfunction. Thus, our main objective was to demonstrate the effectiveness of a modified dynamic contrast-enhanced MRI approach we have developed to detect impairments in brain microvascular function. Read More

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http://dx.doi.org/10.1093/brain/awaa140DOI Listing

Daylight photodynamic therapy for Bowen's disease.

An Bras Dermatol 2020 May 11. Epub 2020 May 11.

Department of Dermatology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

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http://dx.doi.org/10.1016/j.abd.2019.11.012DOI Listing

Allopurinol and valproic acid improve cardiac triglyceride and Na-K-ATPase activity independent of circulating aldosterone in female rats with glucose intolerance.

Arch Physiol Biochem 2020 May 23:1-7. Epub 2020 May 23.

Department of Physiology, HOPE Cardiometabolic Research Team, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.

Studies have shown that cardiac triglyceride accumulation and impaired Na-K-ATPase activity are linked to diabetes- related cardiovascular disease, particularly in women. We hypothesised that allopurinol (ALL) and valproic acid (VPA) treatment would improve cardiac triglyceride and Na-K-ATPase activity independent of circulating aldosterone in Combined Oral Contraceptive (COC)-induced dysglycemia Rats received COC (1.0 μg ethinylestradiol and 5. Read More

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http://dx.doi.org/10.1080/13813455.2020.1767148DOI Listing

Treatment Patterns Among Patients with Multiple Sclerosis Initiating Second-Line Disease-Modifying Therapy.

Adv Ther 2020 May 20. Epub 2020 May 20.

IBM Watson Health, Cambridge, MA, USA.

Objective: Disease-modifying therapies (DMTs) can reduce multiple sclerosis (MS) relapse rates; however, effectiveness of treatments may vary. It is important to understand real-world treatment patterns in the context of MS relapses. We describe MS relapses related to treatment patterns among patients who switch treatment after their first DMT. Read More

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http://dx.doi.org/10.1007/s12325-020-01367-1DOI Listing

Human papillomavirus 16-positive penile Bowen's disease involving the distal urethra: A case report.

SAGE Open Med Case Rep 2020 13;8:2050313X20918985. Epub 2020 May 13.

Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

A 79-year-old man visited our hospital with a chief complaint of erythema around the urethral orifice of the glans, and a diagnosis of penile Bowen's disease was made by penile skin biopsy. Initially, local tumor resection with skin grafting from the femoral skin was performed. However, histopathological examination revealed a positive urethral margin of tumor. Read More

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http://dx.doi.org/10.1177/2050313X20918985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223195PMC

Psychosocial aspects of periodontal disease diagnosis and treatment: A qualitative study.

J Clin Periodontol 2020 May 19. Epub 2020 May 19.

Department of Oral Sciences, Faculty of Dentistry, University of Otago, New Zealand.

Aims: Patient-reported outcomes have attracted interest as there has been a shift from clinician-centric endpoints. This qualitative study aimed to develop an understanding of the psychosocial impact of periodontitis and its treatment.

Materials And Methods: Fourteen adults were asked to document their experiences of untreated periodontitis and non-surgical periodontal therapy at a university clinic, using written or audio-recorded diaries. Read More

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http://dx.doi.org/10.1111/jcpe.13309DOI Listing

Comparison of skin biopsy sample processing and storage methods on high dimensional immune gene expression using the Nanostring nCounter system.

Diagn Pathol 2020 May 15;15(1):57. Epub 2020 May 15.

School of Medical Science and Menzies Health Institute QLD, Griffith University, Gold Coast, Queensland, 4222, Australia.

Background: Digital multiplex gene expression profiling is overcoming the limitations of many tissue-processing and RNA extraction techniques for the reproducible and quantitative molecular classification of disease. We assessed the effect of different skin biopsy collection/storage conditions on mRNA quality and quantity and the NanoString nCounter™ System's ability to reproducibly quantify the expression of 730 immune genes from skin biopsies.

Methods: Healthy human skin punch biopsies (n = 6) obtained from skin sections from four patients undergoing routine abdominoplasty were subject to one of several collection/storage protocols, including: i) snap freezing in liquid nitrogen and transportation on dry ice; ii) RNAlater (ThermoFisher) for 24 h at room temperature then stored at - 80 °C; iii) formalin fixation with further processing for FFPE blocks; iv) DNA/RNA shield (Zymo) stored and shipped at room temperature; v) placed in TRIzol then stored at - 80 °C; vi) saline without RNAse for 24 h at room temperature then stored at - 80 °C. Read More

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http://dx.doi.org/10.1186/s13000-020-00974-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229590PMC

Understanding the Return of Genomic Sequencing Results Process: Content Review of Participant Summary Letters in the eMERGE Research Network.

J Pers Med 2020 May 13;10(2). Epub 2020 May 13.

Genomic Medicine Institute, Geisinger, Danville, PA 17822, USA.

A challenge in returning genomic test results to research participants is how best to communicate complex and clinically nuanced findings to participants in a manner that is scalable to the large numbers of participants enrolled. The purpose of this study was to examine the features of genetic results letters produced at each Electronic Medical Records and Genomics (eMERGE3) Network site to assess their readability and content. Letters were collected from each site, and a qualitative analysis of letter content and a quantitative analysis of readability statistics were performed. Read More

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http://dx.doi.org/10.3390/jpm10020038DOI Listing

Vaccine Candidate Brucella melitensis 16M Is Safe in a Pregnant Sheep Model and Confers Protection.

mSphere 2020 May 13;5(3). Epub 2020 May 13.

College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA

As a natural host species for , pregnant sheep offer an ideal model to evaluate vaccine candidates for safety. strain Rev. 1 has been used almost exclusively to prevent brucellosis in small ruminants, but it causes abortions when given to pregnant animals. Read More

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http://dx.doi.org/10.1128/mSphere.00120-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227765PMC

Distinguishing Between Dermatologic Disorders of the Face, Nasal Planum, and Ears: Great Lookalikes in Feline Dermatology.

Authors:
Kimberly Coyner

Vet Clin North Am Small Anim Pract 2020 Jul 6;50(4):823-882. Epub 2020 May 6.

Dermatology Clinic for Animals, 8300 Quinault Drive NE, Suite A, Lacey, WA 98516, USA. Electronic address:

Facial dermatitis in cats can be caused by a broad range of infectious, allergic, immune-mediated and neoplastic disorders with very different treatments and prognoses. Baseline dermatologic diagnostics (skin scrapings for mites, cytology for infection and to characterize inflammatory infiltrate, and dermatophyte culture) are required, as well as possible further diagnostics, including therapeutic trials for parasites and feeding a hypoallergenic diet, bacterial culture, and skin biopsies for histopathology in order to achieve a diagnosis. Clinical presentations of diseases affecting different parts of the feline face are presented and discussed. Read More

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http://dx.doi.org/10.1016/j.cvsm.2020.03.008DOI Listing

COVID-19 and paediatric health services: A survey of paediatric physicians in Australia and New Zealand.

J Paediatr Child Health 2020 May 4. Epub 2020 May 4.

Infectious Diseases Department, Perth Children's Hospital, Perth, Western Australia, Australia.

Aims: COVID-19 is now a global pandemic. At the time of survey, fewer than 150 children in Australia and New Zealand had documented infection. The aim of this study was to assess attitudes, readiness and confidence in the early stages of the COVID-19 pandemic through an online survey of paediatric physicians and sub-specialists across Australia and New Zealand. Read More

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http://dx.doi.org/10.1111/jpc.14903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267532PMC

Prevalence of the EGFR T790M and other resistance mutations in the Australian population and histopathological correlation in a small subset of cases.

Pathology 2020 Jun 28;52(4):410-420. Epub 2020 Apr 28.

Histopathology Department, Douglass Hanly Moir Pathology, Macquarie Park, NSW, Australia; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia; Sydney Medical School, University of Sydney, NSW, Australia.

We sought to review the prevalence of EGFR T790M and other EGFR mutations associated with either proven or probable tyrosine kinase inhibitor (TKI) resistance in the Australasian lung cancer population and to perform histopathological correlation in a subset of cases. Retrospective statistical analysis was performed on a set of targeted lung cancer gene mutation tests (FIND IT gene panel) performed at Sonic Healthcare during 2018 and early 2019. A total of 1833 lung adenocarcinoma tumour samples underwent somatic mutation testing. Read More

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http://dx.doi.org/10.1016/j.pathol.2020.03.003DOI Listing

SF3B1-mutant myelodysplastic syndrome as a distinct disease subtype - A Proposal of the International Working Group for the Prognosis of Myelodysplastic Syndromes (IWG-PM).

Blood 2020 Apr 29. Epub 2020 Apr 29.

University of Pavia, Pavia, Italy.

The 2016 revision of the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues is characterized by a closer integration of morphology and molecular genetics. Notwithstanding, the myelodysplastic syndrome (MDS) with isolated del(5q) remains so far the only MDS subtype defined by a genetic abnormality. About half of MDS patients carry somatic mutations in spliceosome genes, with SF3B1 being the most commonly mutated one. Read More

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http://dx.doi.org/10.1182/blood.2020004850DOI Listing

CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets.

Int J Mol Sci 2020 Apr 24;21(8). Epub 2020 Apr 24.

Molecular Medicine Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

Sarcomas represent one of the most challenging tumor types to treat due to their diverse nature and our incomplete understanding of their underlying biology. Recent work suggests cyclin-dependent kinase (CDK) pathway activation is a powerful driver of sarcomagenesis. CDK proteins participate in numerous cellular processes required for normal cell function, but their dysregulation is a hallmark of many pathologies including cancer. Read More

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http://dx.doi.org/10.3390/ijms21083018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215455PMC

The Exceptional Responders Initiative: Feasibility of A National Cancer Institute Pilot Study.

J Natl Cancer Inst 2020 Apr 27. Epub 2020 Apr 27.

Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD.

Background: Tumor molecular profiling from patients experiencing exceptional responses to systemic therapy may provide insights into cancer biology and improve treatment tailoring. This pilot study evaluates the feasibility of identifying exceptional responders retrospectively, obtaining pre-exceptional response treatment tumor tissues, and analyzing them with state-of-the-art molecular analysis tools to identify potential molecular explanations for responses.

Methods: Exceptional response was defined as partial (PR) or complete (CR) response to a systemic treatment with population PR or CR rate < 10%, or an unusually long response (e. Read More

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http://dx.doi.org/10.1093/jnci/djaa061DOI Listing

Definitive Chemoradiotherapy for Locally Advanced, Lymph-node Positive, Nonmetastatic Penile Squamous Cell Carcinoma.

Clin Genitourin Cancer 2020 Mar 3. Epub 2020 Mar 3.

Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT. Electronic address:

Introduction: Locally advanced penile cancer is rare, with few reported studies on the therapeutic role of chemoradiotherapy. We sought to characterize the efficacy and toxicity of definitive chemoradiotherapy for locally advanced, node-positive, squamous cell carcinoma of the penis.

Materials And Methods: Six patients who had refused or were ineligible for surgical resection of clinically staged node-positive squamous cell penile cancer were treated with definitive chemoradiotherapy using either weekly cisplatin or 2 cycles of mitomycin C/5-fluorouracil. Read More

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http://dx.doi.org/10.1016/j.clgc.2020.02.007DOI Listing
March 2020
1.693 Impact Factor

Successful treatment for multiple Bowen's disease using photodynamic therapy: A case report.

Photodiagnosis Photodyn Ther 2020 Apr 21:101783. Epub 2020 Apr 21.

Department of Dermatology, Huadong Hospital, Fudan University, Shanghai 200040, PR China. Electronic address:

Bowen's disease, also named squamous cell carcinoma in situ, is usually treated by surgical excision. However, surgery could cause scars and influence joint function. It is also not suitable to patients with large area of lesions or multiple lesions. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101783DOI Listing

Rotavirus Vaccine is Effective Against Rotavirus Gastroenteritis Resulting in Outpatient Care: Results from the MAAGE Study.

Clin Infect Dis 2020 Apr 23. Epub 2020 Apr 23.

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA.

Background: Rotavirus is a common cause of severe pediatric acute gastroenteritis (AGE). Two vaccines are licensed in the United States and have demonstrated high effectiveness against moderate to severe disease. However, fewer data are available on rotavirus vaccine effectiveness (VE) against milder disease. Read More

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http://dx.doi.org/10.1093/cid/ciaa466DOI Listing

Proteomics: An emerging approach for the diagnosis and classification of cutaneous squamous cell carcinoma and its precursors.

J Dermatol Sci 2020 Apr 7. Epub 2020 Apr 7.

Centre for Translational Skin Research, The University of Sydney, Westmead, Australia; Department of Dermatology, Westmead Hospital, Westmead, Australia. Electronic address:

Cutaneous squamous cell carcinoma (cSCC) and its precursors, actinic keratosis (AK) and Bowen's disease (BD), are the most common types of keratinocytic skin lesions (KSL) which account for the majority of non-melanoma skin cancer lethality. Currently, clinical and histopathological criteria are used for the diagnosis, classification and therapeutic intervention of KSLs, however discrepancies exist between the clinical presentations and histologic analyses of these lesions, making the diagnosis difficult. The identification of biomarkers as companion diagnostics for accurately stratifying KSL types is required to support the paradigm shift in current cancer care to personalised, precision medicine and ameliorate the negative impact of misdiagnoses or delayed diagnoses on patient outcome. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2020.03.008DOI Listing

Inactivation of severe acute respiratory syndrome coronavirus 2 in plasma and platelet products using a riboflavin and ultraviolet light-based photochemical treatment.

Vox Sang 2020 Apr 20. Epub 2020 Apr 20.

Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Background And Objective: Severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is a member of the coronavirus family. Coronavirus infections in humans are typically associated with respiratory illnesses; however, viral RNA has been isolated in serum from infected patients. Coronaviruses have been identified as a potential low-risk threat to blood safety. Read More

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http://dx.doi.org/10.1111/vox.12937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264728PMC

Reliability of multimodal MRI brain measures in youth at risk for mental illness.

Brain Behav 2020 Apr 18:e01609. Epub 2020 Apr 18.

Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada.

Introduction: A new generation of large-scale studies is using neuroimaging to investigate adolescent brain development across health and disease. However, imaging artifacts such as head motion remain a challenge and may be exacerbated in pediatric clinical samples. In this study, we assessed the scan-rescan reliability of multimodal MRI in a sample of youth enriched for risk of mental illness. Read More

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http://dx.doi.org/10.1002/brb3.1609DOI Listing

Naturally occurring modified ribonucleosides.

Wiley Interdiscip Rev RNA 2020 Apr 16:e1595. Epub 2020 Apr 16.

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.

The chemical identity of RNA molecules beyond the four standard ribonucleosides has fascinated scientists since pseudouridine was characterized as the "fifth" ribonucleotide in 1951. Since then, the ever-increasing number and complexity of modified ribonucleosides have been found in viruses and throughout all three domains of life. Such modifications can be as simple as methylations, hydroxylations, or thiolations, complex as ring closures, glycosylations, acylations, or aminoacylations, or unusual as the incorporation of selenium. Read More

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http://dx.doi.org/10.1002/wrna.1595DOI Listing

Bowen disease with matrical differentiation: report of an exceptional histopathologic presentation.

J Cutan Pathol 2020 Apr 16. Epub 2020 Apr 16.

Dermatopathology Bodensee, Friedrichshafen, Germany.

Matrical differentiation is the distinctive feature of pilomatricoma and other purely matrical adnexal neoplasms; additionally, foci of matrical differentiation have been also described in hybrid cysts of Gardner syndrome, as well as in a wide variety of benign and malignant cutaneous tumors, including basal cell carcinoma. We report an exceptional case of Bowen disease exhibiting multiple foci of matrical differentiation, as confirmed by means of immunohistochemical studies. Several types of divergent, non-squamous differentiation have been exceptionally reported in cutaneous squamous cell carcinoma in situ (cSCCIS), including sebaceous, mucinous/glandular, poroid, tricholemmal, and neuroendocrine differentiation; matrical differentiation may be added to this list. Read More

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http://dx.doi.org/10.1111/cup.13714DOI Listing

Geographic Differences in COVID-19 Cases, Deaths, and Incidence - United States, February 12-April 7, 2020.

Authors:

MMWR Morb Mortal Wkly Rep 2020 Apr 17;69(15):465-471. Epub 2020 Apr 17.

Community transmission of coronavirus disease 2019 (COVID-19) was first detected in the United States in February 2020. By mid-March, all 50 states, the District of Columbia (DC), New York City (NYC), and four U.S. Read More

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http://dx.doi.org/10.15585/mmwr.mm6915e4DOI Listing

evolution of herpes simplex virus 1 (HSV-1) reveals selection for syncytia and other minor variants in cell culture.

Virus Evol 2020 Jan 12;6(1):veaa013. Epub 2020 Apr 12.

Departments of Biology, and Biochemistry and Molecular Biology, The Huck Institutes of the Life Sciences, and Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA, USA.

The large dsDNA virus herpes simplex virus 1 (HSV-1) is considered to be genetically stable, yet it can rapidly evolve in response to strong selective pressures such as antiviral treatment. Deep sequencing has revealed that clinical and laboratory isolates of this virus exist as populations that contain a mixture of minor alleles or variants, similar to many RNA viruses. The classic virology approach of plaque purifying virus creates a genetically homogenous population, but it is not clear how closely this represents the mixed virus populations found in nature. Read More

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http://dx.doi.org/10.1093/ve/veaa013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151645PMC
January 2020

Triple collision tumor comprising Merkel cell carcinoma with an unusual immunophenotype, squamous cell carcinoma in situ, and basal cell carcinoma.

J Cutan Pathol 2020 Apr 3. Epub 2020 Apr 3.

Division of Dermatology, University of Louisville School of Medicine, Louisville, Kentucky, USA.

Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine cancer which almost always exhibits the cytokeratin (CK)20+/thyroid transcription factor (TTF)-1- immunophenotype. MCC may occur concurrently with squamous cell carcinoma, Bowen disease, and/or basal cell carcinoma (BCC), with some evidence that MCCs which occur in conjunction with other neoplasms exhibit different immunophenotypes compared to pure MCC cases. We present a case of CK20-/TTF-1+ MCC concurrent with Bowen disease and BCC, and discuss possible differences in the pathogenesis of pure vs combined MCC. Read More

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http://dx.doi.org/10.1111/cup.13698DOI Listing

Enhanced visualization of blood and pigment in multispectral skin dermoscopy.

Skin Res Technol 2020 Mar 29. Epub 2020 Mar 29.

Department of Dermatology, KU Leuven, Leuven, Belgium.

Background And Objectives: Dermoscopy has proven its value in the diagnosis of skin cancer and, therefore, is well established in daily dermatology practice. Up until now, analogue white light dermoscopy is the standard. Multispectral dermoscopy is based on illumination of the skin with narrowband light sources with different wavelengths. Read More

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http://dx.doi.org/10.1111/srt.12859DOI Listing

Conversational topics of social media messages associated with state-level mental distress rates.

J Ment Health 2020 Apr 30;29(2):234-241. Epub 2020 Mar 30.

Office of Strategy and Innovation, National Center for Injury Prevention and Control, U.S. Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.

Upstream public health indicators of poor mental health in the United States (U.S.) are currently measured by national telephone-based surveys; however, results are delayed by 1-2 years, limiting real-time assessment of trends. Read More

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http://dx.doi.org/10.1080/09638237.2020.1739251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217347PMC

Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) - United States, February 12-March 16, 2020.

Authors:

MMWR Morb Mortal Wkly Rep 2020 Mar 27;69(12):343-346. Epub 2020 Mar 27.

Globally, approximately 170,000 confirmed cases of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) have been reported, including an estimated 7,000 deaths in approximately 150 countries (1). On March 11, 2020, the World Health Organization declared the COVID-19 outbreak a pandemic (2). Data from China have indicated that older adults, particularly those with serious underlying health conditions, are at higher risk for severe COVID-19-associated illness and death than are younger persons (3). Read More

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http://dx.doi.org/10.15585/mmwr.mm6912e2DOI Listing

A rare case of Bowen's disease of the nipple: Literature review and management pathway.

Breast J 2020 Mar 24. Epub 2020 Mar 24.

Department of Plastic, Reconstructive and Burns Surgery, Royal North Shore Hospital, St Leonards, NSW, Australia.

Introduction: Bowen's disease or squamous cell carcinoma in situ is a precursor malignant neoplasm restricted to the epidermis. Clinically and histologically, Bowen's disease of the nipple can resemble Paget's disease. It is crucial to differentiate between the two with immunohistological staining in order to provide the appropriate treatment. Read More

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http://dx.doi.org/10.1111/tbj.13824DOI Listing

NS4/5 mutations enhance flavivirus Bamaga virus infectivity and pathogenicity in vitro and in vivo.

PLoS Negl Trop Dis 2020 03 23;14(3):e0008166. Epub 2020 Mar 23.

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.

Flaviviruses such as yellow fever, dengue or Zika viruses are responsible for significant human and veterinary diseases worldwide. These viruses contain an RNA genome, prone to mutations, which enhances their potential to emerge as pathogens. Bamaga virus (BgV) is a mosquito-borne flavivirus in the yellow fever virus group that we have previously shown to be host-restricted in vertebrates and horizontally transmissible by Culex mosquitoes. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089401PMC

Bowen's disease.

BMJ 2020 Mar 20;368:m813. Epub 2020 Mar 20.

Nottingham NHS Treatment Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.

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http://dx.doi.org/10.1136/bmj.m813DOI Listing

Imaging findings of Bowen's disease: A comparison between ultrasound biomicroscopy and conventional high-frequency ultrasound.

Skin Res Technol 2020 Mar 20. Epub 2020 Mar 20.

Department of Medical Ultrasound, Shanghai Skin Disease Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.

Objectives: To compare the imaging findings of Bowen's disease (BD) between ultrasound biomicroscopy (UBM) and conventional high-frequency ultrasound (HFUS).

Methods: A total of 29 pathologically proven BD lesions in 28 patients were retrospectively enrolled in the study, and all were after surgery. All the lesions were imaged with both UBM and HFUS. Read More

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http://dx.doi.org/10.1111/srt.12849DOI Listing
March 2020
1.536 Impact Factor

Decreased Susceptibility to Azithromycin in Clinical Shigella Isolates Associated with HIV and Sexually Transmitted Bacterial Diseases, Minnesota, USA, 2012-2015.

Emerg Infect Dis 2020 Apr;26(4):667-674

Shigellosis outbreaks caused by Shigella with decreased susceptibility to azithromycin (DSA-Shigella) among men who have sex with men (MSM) have been reported worldwide. We describe sexual health indicators and antimicrobial drug resistance for shigellosis cases in Minnesota, USA. We analyzed a sample of isolates received during 2012-2015 and cross-referenced cases with the Minnesota Department of Health Sexually Transmitted Disease Database to ascertain patients' HIV status and recent chlamydia, gonorrhea, and syphilis infections. Read More

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http://dx.doi.org/10.3201/eid2604.191031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101095PMC

Diagnostic Clues for Pagetoid Bowen's Disease.

Indian J Dermatol 2020 Mar-Apr;65(2):167-169

Department of Dermatology, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan. E-mail:

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http://dx.doi.org/10.4103/ijd.IJD_362_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059465PMC

Incidence rates of health outcomes of interest among Chinese children exposed to selected vaccines in Yinzhou Electronic Health Records: A population-based retrospective cohort study.

Vaccine 2020 Apr 13;38(18):3422-3428. Epub 2020 Mar 13.

School of Public Health, Fudan University 138 Yi Xue Yuan Road, Shanghai 200032, China. Electronic address:

Introduction: Oral poliovirus vaccine (OPV) and diphtheria-tetanus-acellular pertussis vaccine (DTaP) are widely used in China while Haemophilus influenzae type b vaccines (Hib) and a DTaP, inactivated poliovirus (IPV) andHib polysaccharide conjugated to tetanus protein (PRP ~ T) combined vaccine (DTaP-IPV//PRP ~ T) have lower coverage. There are limited safety data on these vaccines in Chinese pediatric populations.

Methods: To estimate incidence rates (IRs) of health outcomes of interest (HOIs) among children exposed to OPV, DTaP, Hib, and DTaP-IPV//PRP ~ T, we conducted a retrospective cohort study using a population-based electronic health record (EHR) database in Yinzhou district, Ningbo City. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.013DOI Listing

When to suspect a non-melanoma skin cancer.

BMJ 2020 Mar 11;368:m692. Epub 2020 Mar 11.

Department of Dermatology, Nottingham NHS Treatment Centre, Nottingham NG7 2FT, UK.

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http://dx.doi.org/10.1136/bmj.m692DOI Listing

Variant Interpretation for Dilated Cardiomyopathy: Refinement of the American College of Medical Genetics and Genomics/ClinGen Guidelines for the DCM Precision Medicine Study.

Circ Genom Precis Med 2020 Apr 11;13(2):e002480. Epub 2020 Mar 11.

Division of Human Genetics, Department of Internal Medicine (A.M., D.D.K., E.J., C.S., J.M., T.A., R.E.H.), The Ohio State University, Columbus.

Background: The hypothesis of the Dilated Cardiomyopathy Precision Medicine Study is that most dilated cardiomyopathy has a genetic basis. The study returns results to probands and, when indicated, to relatives. While both the American College of Medical Genetics and Genomics/Association for Molecular Pathology and ClinGen's -cardiomyopathy specifications provide relevant guidance for variant interpretation, further gene- and disease-specific considerations were required for dilated cardiomyopathy. Read More

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http://dx.doi.org/10.1161/CIRCGEN.119.002480DOI Listing

Evaluation for Skin Cancer and Precancer in Patients With Vitiligo Treated With Long-term Narrowband UV-B Phototherapy.

JAMA Dermatol 2020 Mar 11. Epub 2020 Mar 11.

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea.

Importance: Narrowband UV-B (NBUVB) phototherapy has been the mainstay in the treatment of vitiligo, but its long-term safety in terms of photocarcinogenesis has not been established.

Objectives: To investigate the risks of skin cancer and precancerous lesions among patients with vitiligo undergoing NBUVB phototherapy, based on the number of NBUVB phototherapy sessions.

Design, Setting, And Participants: This nationwide population-based retrospective cohort study enrolled 60 321 patients with vitiligo 20 years or older between January 1, 2007, and December 31, 2017. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.0218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066522PMC

Effects of Inactivated Vaccination on Molokai-Origin Wild Pigs Experimentally Infected with Virulent .

Pathogens 2020 Mar 7;9(3). Epub 2020 Mar 7.

SaBio Instituto de Investigación en Recursos Cinegéticos IREC, University Castilla la Mancha & CSIC, 13003 Ciudad Real, Spain.

The wild pig population on Molokai, Hawaii, USA is a possible reservoir for bovine tuberculosis, caused by , and has been implicated in decades past as the source of disease for the island's domestic cattle. Heat-inactivated vaccines have been effective for reducing disease prevalence in wild boar in Spain and could prove useful for managing in Molokai wild pigs. We designed an experiment to test this vaccine in wild pigs of Molokai genetics. Read More

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http://dx.doi.org/10.3390/pathogens9030199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157231PMC

Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale.

Kidney Int Rep 2020 Mar 13;5(3):278-288. Epub 2019 Dec 13.

Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Introduction: Much of the higher risk for end-stage kidney disease (ESKD) in African American individuals relates to ancestry-specific variation in the apolipoprotein L1 gene (). Relative to kidneys from European American deceased-donors, kidneys from African American deceased-donors have shorter allograft survival and African American living-kidney donors more often develop ESKD. The National Institutes of Health (NIH)-sponsored Long-term Kidney Transplantation Outcomes Network (APOLLO) is prospectively assessing kidney allograft survival from donors with recent African ancestry based on donor and recipient genotypes. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056919PMC

Malignant circumscribed acral hypokeratosis.

JAAD Case Rep 2020 Mar 19;6(3):214-216. Epub 2020 Feb 19.

Dermatopathology Partners of Knoxville, Knoxville, Tennessee.

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http://dx.doi.org/10.1016/j.jdcr.2020.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033305PMC

Bowen disease of the nail apparatus with HPV16 positivity and resolution with human papillomavirus vaccination.

Br J Dermatol 2020 Mar 9. Epub 2020 Mar 9.

Department of Dermatology, School of Medicine, Eulji University, Daejeon, Republic of Korea.

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http://dx.doi.org/10.1111/bjd.18945DOI Listing

Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection.

PLoS Pathog 2020 Mar 5;16(3):e1008298. Epub 2020 Mar 5.

Pathogen & Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, United States of America.

Although acute melioidosis is the most common outcome of Burkholderia pseudomallei infection, we have documented a case, P314, where disease severity lessened with time, and the pathogen evolved towards a commensal relationship with the host. In the current study, we used whole-genome sequencing to monitor this long-term symbiotic relationship to better understand B. pseudomallei persistence in P314's sputum despite intensive initial therapeutic regimens. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077878PMC

Photodynamic therapy in combination with surgery for the treatment of an extensive squamous cell carcinoma in situ - a case report.

Photodiagnosis Photodyn Ther 2020 Feb 29:101700. Epub 2020 Feb 29.

Sao Carlos Institute of Physics, University of Sao Paulo, Brazil; Hagler Fellow, Texas A&M University, College Station, TX, USA.

The combination of multiple sessions of Photodynamic therapy (PDT) and surgery have been used to treat extensive superficial lesion of squamous cell carcinoma in situ. Methyl aminolevulinate (MAL) mediated PDT was applied to reduce the tumoral area and a small surgical removal was performed to complete elimination of the lesion. The reduction of the tumor area avoided the need for a skin graft application as well as possible postoperative complications, offering a more favorable cosmetic outcome. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101700DOI Listing
February 2020

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants.

Nat Commun 2020 02 25;11(1):1044. Epub 2020 Feb 25.

Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, UK.

The inclusion of familial myeloid malignancies as a separate disease entity in the revised WHO classification has renewed efforts to improve the recognition and management of this group of at risk individuals. Here we report a cohort of 86 acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) families with 49 harboring germline variants in 16 previously defined loci (57%). Whole exome sequencing in a further 37 uncharacterized families (43%) allowed us to rationalize 65 new candidate loci, including genes mutated in rare hematological syndromes (ADA, GP6, IL17RA, PRF1 and SEC23B), reported in prior MDS/AML or inherited bone marrow failure series (DNAH9, NAPRT1 and SH2B3) or variants at novel loci (DHX34) that appear specific to inherited forms of myeloid malignancies. Read More

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http://dx.doi.org/10.1038/s41467-020-14829-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042299PMC
February 2020
10.742 Impact Factor

Akt Pathway Inhibitors.

Curr Top Med Chem 2020 ;20(10):883-900

Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA 30341, United States.

Cancer is a devastating disease that has plagued humans from ancient times to this day. After decades of slow research progress, promising drug development, and the identification of new targets, the war on cancer was launched, in 1972. The P13K/Akt pathway is a growth-regulating cellular signaling pathway, which in many human cancers is over-activated. Read More

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http://dx.doi.org/10.2174/1568026620666200224101808DOI Listing
January 2020