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    Dementia worry: a psychological examination of an unexplored phenomenon.
    Eur J Ageing 2012 Dec 22;9(4):275-284. Epub 2012 Sep 22.
    Department of Psychological Ageing Research, Institute of Psychology, Heidelberg University, Heidelberg, Germany.
    According to recent surveys, dementia worry (DW) is a widespread phenomenon in mid-life and old age, at least in Western populations. DW has been shown to be only loosely related to sociodemographic factors. Unfortunately, the concept of DW has found only very little conceptual and empirical attention in previous research. Read More

    MicroRNAs as biomarkers in chronic kidney disease.
    Curr Opin Nephrol Hypertens 2017 Aug 12. Epub 2017 Aug 12.
    Wales Kidney Research Unit, School of Medicine, University Hospital Wales, Cardiff University, Cardiff, UK.
    Purpose Of Review: This review summarizes recent data supporting the concept that urinary microRNAs are a useful new class of biomarker. They may improve capacity to stratify patients with chronic kidney disease according to risk of progression, and may also inform about response to therapy.

    Recent Findings: MicroRNAs are present, stable and readily quantifiable in tissues and body fluids, including urine, and have widespread importance as regulators in the kidney. Read More

    The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission.
    Tuberculosis (Edinb) 2017 Sep 14;106:91-98. Epub 2017 Jul 14.
    Department of Microbiology, Immunology and Pathology, Colorado State University, Campus Delivery 1682, Fort Collins, CO 80523, USA. Electronic address:
    In endemic countries more than 20% of tuberculosis (TB) cases are in infants and children. Current animal models study TB during adulthood but animal models for infant TB are scarce. Here we propose that minipigs can be used as an animal model to study adult, adolescent and infant TB including natural transmission. Read More

    Risk factors for development of melanoma brain metastasis and disease progression: a single-center retrospective analysis.
    Melanoma Res 2017 Aug 10. Epub 2017 Aug 10.
    Departments of aDermatology bSurgery cMedicine dRadiation Oncology eOncological Sciences fHuntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
    Melanoma metastasis to the brain is associated with a poor prognosis. We sought to determine patient demographics and primary tumor factors associated with the development of brain metastasis (BM) and survival. We also investigated whether the BM detection setting (routine screening vs. Read More

    Genital Bowen's Disease in a Bulgarian Patient: Complete Remission after Surgical Approach.
    Open Access Maced J Med Sci 2017 Jul 21;5(4):545-546. Epub 2017 Jul 21.
    "Onkoderma" - Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26 blvd., Sofia, Bulgaria.
    A 60-year-old male patient presented with complaints of persistent red to a brown-colored plaque on his scrotum, with duration of approximately three years. The patient had been treated with oral and topical antifungals for inguinal tinea for several months and after that with topical corticosteroids for eczema for several more months. None of the regimens achieved any therapeutic effect. Read More

    Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements.
    Arch Toxicol 2017 Aug 3. Epub 2017 Aug 3.
    Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center Vienna, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.
    Arsenic is one of the most important human carcinogens and environmental pollutants. However, the evaluation of the underlying carcinogenic mechanisms is challenging due to the lack of suitable in vivo and in vitro models, as distinct interspecies differences in arsenic metabolism exist. Thus, it is of high interest to develop new experimental models of arsenic-induced skin tumorigenesis in humans. Read More

    [The Dutch College of General Practitioners practice guideline 'Suspicious skin lesions'].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1897
    *Namens de NHG-werkgroep Verdachte huidafwijkingen, waarvan de leden aan het eind van dit artikel vermeld staan.
    - The Dutch College of General Practitioners practice guideline 'Suspicious skin lesions' provides recommendations for diagnosis, treatment and referral for the most common premalignant and malignant skin disorders.- The practice guideline includes a flowchart which starts by looking at the colour and surface of the skin lesion to direct the general practitioner to the most likely diagnosis.- In case of strong suspicion of squamous cell carcinoma, keratoacanthoma or melanoma and in case of basal cell carcinoma or Bowen's disease with high-risk characteristics, the general practitioner will refer the patient to a dermatologist. Read More

    A Multicenter Nominal Group Study to Rank Outcomes Important to Patients, and Their Representation in Existing Composite Outcome Measures for Psoriatic Arthritis.
    J Rheumatol 2017 Aug 1. Epub 2017 Aug 1.
    From the Royal National Hospital for Rheumatic Diseases; Department of Pharmacy and Pharmacology, University of Bath; PsAZZ Psoriatic Arthritis Support Group, Bath; University of the West of England, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, UK; St. Vincent's University Hospital and the Conway Institute, University College Dublin (UCD), Dublin, Ireland; Department of Medical Humanities, Patient Research Partner, VU University Medical Centre, Amsterdam, the Netherlands; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. This report is from independent research funded by the National Institute for Health Research (Programme Grants for Applied Research, Early detection to improve outcome in patients with undiagnosed psoriatic arthritis, RP-PG-1212-20007). W. Tillett, MBChB PhD, Royal National Hospital for Rheumatic Diseases, and Department of Pharmacy and Pharmacology, University of Bath; E. Dures, MSc, PhD, University of the West of England; S. Hewlett, FRCN, PhD, MA, University of the West of England; P.S. Helliwell, MA, MD, LIRMM, University of Leeds; O. FitzGerald, MD, FRCPI, FRCP (UK), St. Vincent's University Hospital and the Conway Institute, UCD; M. Brooke, Patient Research Partner, Chair, PsAZZ Psoriatic Arthritis Support Group; J. James, Patient Research Partner; J. Lord, Patient Research Partner; C. Bowen, Patient Research Partner; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, VU University Medical Centre; A. Orbai, MD, Division of Rheumatology, Johns Hopkins University School of Medicine; N. McHugh, MD, FRCP, FRCPath, Royal National Hospital for Rheumatic Diseases, and Department of Pharmacy and Pharmacology, University of Bath. Address correspondence to Dr. W. Tillett, Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath, BA11RL, UK. E-mail: Accepted for publication May 18, 2017.
    Objective: To rank outcomes identified as important to patients with psoriatic arthritis (PsA) and examine their representation in existing composite measures.

    Methods: Seven nominal group technique (NGT) meetings took place at 4 hospital sites. Two sorting rounds were conducted to generate a shortlist of outcomes followed by a group discussion and final ranking. Read More

    Lobulated Bowen's Disease with a Clear Cell Change.
    Ann Dermatol 2017 Aug 21;29(4):487-490. Epub 2017 Jun 21.
    Department of Dermatology, School of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea.
    Bowen's disease usually manifests as a slowly enlarging erythematous scaly patch or plaque. An uncommon variant of Bowen's disease showing a verrucous appearance has been reported and a distinct variant with a prominent clear cell change on histopathology, in addition to a verrucous surface change, was also reported. We describe novel form of Bowen's disease having a cerebriform appearance and showing histopathologically a significant clear cell change and propose that the clinical term "lobulated Bowen's disease" would be compatible for the description of this unique clinical variant. Read More

    Dosimetric evaluation of a commercial proton spot scanning Monte-Carlo dose algorithm: comparisons against measurements and simulations.
    Phys Med Biol 2017 Jul 27. Epub 2017 Jul 27.
    Department of Radiation Oncology, University of Washington, Seattle, Washington, UNITED STATES.
    Purpose: RaySearch Americas Inc. (NY) has introduced a commercial Monte Carlo dose algorithm (RS-MC) for routine clinical use in proton spot scanning. In this report, we provide a validation of this algorithm against phantom measurements and simulations in GATE/GEANT4 software package. Read More

    A subset of high Gleason grade prostate carcinomas contain a large burden of prostate cancer syndecan-1 positive stromal cells.
    Prostate 2017 Jul 26. Epub 2017 Jul 26.
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.
    Background: There is a pressing need to identify prognostic and predictive biomarkers for prostate cancer to aid treatment decisions in both early and advanced disease settings. Syndecan-1, a heparan sulfate proteoglycan, has been previously identified as a potential prognostic biomarker by multiple studies at the tissue and serum level. However, other studies have questioned its utility. Read More

    Butyrylcholinesterase-knockout reduces fibrillar β-amyloid and conserves (18)FDG retention in 5XFAD mouse model of Alzheimer's disease.
    Brain Res 2017 Sep 17;1671:102-110. Epub 2017 Jul 17.
    Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada; Biomedical Translational Imaging Centre, Halifax, Nova Scotia, Canada; Department of Chemistry and Physics, Mount St. Vincent University, Halifax, Nova Scotia B3M 2J6, Canada; Department of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address:
    Alzheimer's disease (AD) is the most common neurodegenerative disorder causing dementia. One hallmark of the AD brain is the deposition of β-amyloid (Aβ) plaques. AD is also a state of cholinergic dysfunction and butyrylcholinesterase (BChE) associates with Aβ pathology. Read More

    A Preclinical Study in Rhesus Macaques for Cystic Fibrosis to Assess Gene Transfer and Transduction by AAV1 and AAV5 with a Dual-Luciferase Reporter System.
    Hum Gene Ther Clin Dev 2017 Jul 19. Epub 2017 Jul 19.
    6 Department of Medicine, Johns Hopkins University , Baltimore, Maryland.
    Cystic fibrosis (CF) is an autosomal recessive disease that is potentially treatable by gene therapy. Since the identification of the gene encoding CF transmembrane conductance regulator, a number of preclinical and clinical trials have been conducted using the first generation of adeno-associated virus, AAV2. All these studies showed that AAV gene therapy for CF is safe, but clinical benefit was not clearly demonstrated. Read More

    Medialization Laryngoplasty in the Elderly: Outcomes and Expectations.
    Otolaryngol Head Neck Surg 2017 Jul 1:194599817718783. Epub 2017 Jul 1.
    1 Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
    Objective To describe the profile and outcomes of elderly patients undergoing medialization laryngoplasty for vocal cord paralysis. Study Design Case series with retrospective review. Setting Tertiary care hospital. Read More

    Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
    Nat Genet 2017 Jul 17. Epub 2017 Jul 17.
    Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
    We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10(-4)) in 35,962 independent samples using de novo genotyping and imputed genotypes. Read More

    Risk of persistent or recurrent cervical neoplasia in patients with 'pure' adenocarcinoma-in-situ (AIS) or mixed AIS and high-grade cervical squamous neoplasia (cervical intra-epithelial neoplasia grades 2 and 3 (CIN 2/3)): a population-based study.
    BJOG 2017 Jul 5. Epub 2017 Jul 5.
    Institute for Health Research, University of Notre Dame Australia, Fremantle, WA, Australia.
    Objective: To compare outcomes of patients with pure adenocarcinoma-in-situ (AIS) and mixed AIS/CIN 2/3 lesions including the incidence of AIS persistence, recurrence and progression to adenocarcinoma.

    Design: Retrospective cohort study.

    Setting: Statewide population in Western Australia. Read More

    Are scabies and impetigo "normalised"? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections.
    PLoS Negl Trop Dis 2017 Jul 3;11(7):e0005726. Epub 2017 Jul 3.
    Department of Infectious Diseases, Princess Margaret Hospital for Children, Perth, Western Australia.
    Background: Complications of scabies and impetigo such as glomerulonephritis and invasive bacterial infection in Australian Aboriginal children remain significant problems and the overall global burden of disease attributable to these skin infections remains high despite the availability of effective treatment. We hypothesised that one factor contributing to this high burden is that skin infection is under-recognised and hence under-treated, in settings where prevalence is high.

    Methods: We conducted a prospective, cross-sectional study to assess the burden of scabies, impetigo, tinea and pediculosis in children admitted to two regional Australian hospitals from October 2015 to January 2016. Read More

    Urologic Dermatology: a Review.
    Curr Urol Rep 2017 Aug;18(8):62
    Virginia Mason Medical Center, Seattle, WA, USA.
    Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

    Phasor-FLIM as a Screening Tool for the Differential Diagnosis of Actinic Keratosis, Bowen's Disease, and Basal Cell Carcinoma.
    Anal Chem 2017 Aug 18;89(15):8104-8111. Epub 2017 Jul 18.
    Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University , Shenzhen, Guangdong 518060, China.
    The aim of this study was to distinguish basal cell carcinoma (BCC) from actinic keratosis (AK) and Bowen's disease (BD) by fluorescence lifetimes of hematoxylin and eosin (H&E) and phasor analysis. Pseudocolor images of average fluorescence lifetime (τm) exhibited more contrast than conventional bright field and/or fluorescence images of H&E-stained sections. The mean values (μ) of τm distribution (τmμ) in three layers of skin were first explored for comparison with the corresponding layers of AK, BD, and BCC. Read More

    AQP3 small interfering RNA and PLD2 small interfering RNA inhibit the proliferation and promote the apoptosis of squamous cell carcinoma.
    Mol Med Rep 2017 Aug 23;16(2):1964-1972. Epub 2017 Jun 23.
    Department of Dermatology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang 310007, P.R. China.
    Aquaporin 3 (AQP3) and phospholipase D2 (PLD2) are abnormally expressed and/or localized in squamous cell carcinoma (SCC). AQP3 transports glycerol to PLD2 for the synthesis of lipid second messenger, which can mediate the effect of the AQP3/PLD2 signaling module in the regulation of keratinocyte proliferation and differentiation. However, the role of the AQP3/PLD2 signaling module in the pathogenesis of SCC remains to be fully elucidated. Read More

    Novel TMC8 splice site mutation in epidermodysplasia verruciformis and review of HPV infections in patients with the disease.
    J Eur Acad Dermatol Venereol 2017 Jun 24. Epub 2017 Jun 24.
    Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
    Background: Epidermodysplasia verruciformis (EV) is a genodermatosis leading to infections with cutaneous HPV, persistent plane warts and a high rate of non-melanoma skin cancer (NMSC). Biallelic loss-of-function mutations in TMC6 and TMC8 are known to be causative.

    Objective: The aim of this study was to report EV-causing mutations in four patients with EV and to give an overview of all described patients with EV. Read More

    Bowen's disease: Two case reports of a giant and dwarf lesions.
    J Cancer Res Ther 2017 Apr-Jun;13(2):371-373
    Department of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.
    Bowen's disease is a form of intraepidermal squamous cell carcinoma (SCC). It usually presents as a well-demarcated, slow growing erythematous patch, or plaque with a scaly or crusted surface. The size of the tumor varies from a few millimeters to several centimeters. Read More

    Lichenoid keratosis is frequently misdiagnosed as basal cell carcinoma.
    Clin Exp Dermatol 2017 Aug 21;42(6):663-666. Epub 2017 Jun 21.
    Department of Dermatology, Sir Charles Gairdner Hospital, Nedlands, Perth, WA, Australia.
    Lichenoid keratosis (LK), also known as benign lichenoid keratosis or lichen planus-like keratosis, is a solitary, pink to red-brown scaly plaque representing a host immunological response to a variety of precursor lesions. LK is often misdiagnosed as a dermatological malignancy owing to its clinical resemblance to basal cell carcinoma (BCC) or Bowen disease. We performed a retrospective analysis of the pathology records of a series of LK lesions with reference to the demographic features and accuracy of clinical diagnosis. Read More

    Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study.
    Alzheimers Dement 2017 Jun 15. Epub 2017 Jun 15.
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
    Introduction: There may be biologically relevant heterogeneity within typical late-onset Alzheimer's dementia.

    Methods: We analyzed cognitive data from people with incident late-onset Alzheimer's dementia from a prospective cohort study. We determined individual averages across memory, visuospatial functioning, language, and executive functioning. Read More

    Retrospective evaluation of exposure to natural UV radiation: experiences with the online UV history tool in a field study.
    J Dtsch Dermatol Ges 2017 Jun;15(6):610-619
    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine at the University of Erlangen-Nuremberg (FAU), Erlangen, Germany.
    Background: Cutaneous squamous cell carcinoma and multiple actinic keratoses can be recognized as occupational diseases if the site affected has been subjected to additional occupational UV exposure of at least 40 %. An online UV history tool that allows for the quantification of occupational and recreational UV doses was now tested in a field study.

    Patients And Methods: Ninety-nine patients with nonmelanoma skin cancer were examined. Read More

    Assessment of functional liver reserve: old and new in 99mTc-sulfur colloid scintigraphy.
    Nucl Med Commun 2017 Jul;38(7):577-586
    aDepartment of Radiology, School of Medicine, Division of Nuclear Medicine bDepartment of Radiation Oncology, School of Medicine, University of Washington, Seattle, Washington, USA.
    Purpose: A semiquantitative assessment of hepatic reticuloendothelial system function using colloidal particles scintigraphy has been proposed previously as a surrogate for liver function evaluation. In this article, we present an updated method for the overall assessment of technetium-99m (Tc)-sulfur colloid (SC) biodistribution that combines information from planar and attenuation-corrected Tc-SC single-photon emission computed tomography (SPECT) images. The imaging protocol described here was developed as an easy-to-implement method to assess overall and regional liver function changes associated with chronic liver disease. Read More

    Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease.
    PLoS One 2017 5;12(6):e0178987. Epub 2017 Jun 5.
    Department of Molecular Hepatology, Centenary Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
    Background And Aim: Circulating fibroblast activation protein (cFAP) is a constitutively active enzyme expressed by activated fibroblasts that has both dipeptidyl peptidase and endopeptidase activities. We aimed to assess the correlation between cFAP activity and antigen levels and to compare variations in levels.

    Methods: In plasma of 465 control individuals, 368 patients with coronary heart disease (CHD) and 102 hepatitis C virus (HCV) infected patients with severe liver disease before and after liver transplant, cFAP activity levels were measured with a newly developed cFAP activity assay. Read More

    Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy.
    N Engl J Med 2017 07 3;377(4):338-351. Epub 2017 Jun 3.
    From the Institute of Cancer and Genomic Sciences, University of Birmingham (N.D.J.), and University Hospital Birmingham (A.Z.), Birmingham, the Institute of Cancer Research (J.S.B., D.P.D., G.A.), Medical Research Council Clinical Trials Unit at University College London (M.R. Spears, C.L.A., C.G., C.B., M.K.B.P., M.R. Sydes), King's College London and Guy's and St. Thomas' NHS Foundation Trust (S.C.), and Royal Marsden NHS Foundation Trust (C.C.P.), London, Salford Royal NHS Foundation Trust, Salford (N.W.C.), Cardiff University School of Medicine (M.D.M.) and Velindre Cancer Centre (J.F.L.), Cardiff, Gloucestershire Royal Hospital (A.W.S.R.) and Gloucestershire Hospitals NHS Foundation Trust (J.B.), Gloucester, University of Glasgow, Glasgow (R.J.J., J.M.R.), St. James's University Hospital, Leeds (W.R.C.), University Hospital of North-Midlands, Stoke-on-Trent (F.A.), Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter (S.A.), Rosemere Cancer Centre, Royal Preston Hospital, Preston (A.J.B.), Dorset Cancer Centre, Poole Hospital, Poole (S.B.), Royal Derby Hospital, Derby (P.C.), Weston Park Hospital, Sheffield (C.F.), Portsmouth Oncology Centre, Queen Alexandra Hospital, Portsmouth (J.G.), Musgrove Park Hospital, Taunton (E.G.), Hull and East Yorkshire Hospitals NHS Trust, Hull (M.H.), Mount Vernon Cancer Centre, Northwood (P.J.H.), Clatterbridge Cancer Centre, Wirral (Z.I.M.), Brighton and Sussex University Hospitals NHS Trust (F.M.) and Sussex Cancer Centre, Royal Sussex County Hospital (A.R.), Brighton, NHS Highland, Inverness (N.M.), Royal Surrey County Hospital, Guildford (J.M.-K.), Northern Ireland Cancer and Queens University, Belfast (J.O.), Lancashire Teaching Hospitals NHS Trust, Preston (O.P.), Churchill Hospital, Oxford (A.P.), Shrewsbury and Telford Hospitals NHS Trust, Shrewsbury (N.N.S.), East Kent Hospitals NHS Trust, Canterbury (C.T.), Swansea University College of Medicine, Swansea (J. Wagstaff), and Christie NHS Foundation Trust, Manchester (J. Wylie) - all in the United Kingdom; and the Department of Medical Oncology, Kantonsspital St. Gallen, St. Gallen (S.G.), and University Hospital of Lausanne, Lausanne (D.R.B.) - both in Switzerland. Two of the authors (D.M., R.M.) were unaffiliated lay members of the STAMPEDE investigators.
    Background: Abiraterone acetate plus prednisolone improves survival in men with relapsed prostate cancer. We assessed the effect of this combination in men starting long-term androgen-deprivation therapy (ADT), using a multigroup, multistage trial design.

    Methods: We randomly assigned patients in a 1:1 ratio to receive ADT alone or ADT plus abiraterone acetate (1000 mg daily) and prednisolone (5 mg daily) (combination therapy). Read More

    mHealth App for Risk Assessment of Pigmented and Nonpigmented Skin Lesions-A Study on Sensitivity and Specificity in Detecting Malignancy.
    Telemed J E Health 2017 May 31. Epub 2017 May 31.
    6 Department of Dermatology and Allergology, Ludwig-Maximilian University , Munich, Germany .
    Background: With the advent of smartphone devices, an increasing number of mHealth applications that target melanoma identification have been developed, but none addresses the general context of melanoma and nonmelanoma skin cancer identification.

    Introduction: In this study a smartphone application using fractal and classical image analysis for the risk assessment of skin lesions is systematically evaluated to determine its sensitivity and specificity in the diagnosis of melanoma and nonmelanoma skin cancer along with actinic keratosis and Bowen's disease.

    Materials And Methods: In the Department of Dermatology, Catharina Hospital Eindhoven, The Netherlands, 341 melanocytic and nonmelanocytic lesions were imaged using SkinVision app; 239 underwent histopathological examination, while the rest of 102 lesions were clinically diagnosed as clearly benign and not removed. Read More

    The immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection.
    BMC Immunol 2017 May 19;18(1):27. Epub 2017 May 19.
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Drive S.W., Atlanta, GA, 30310, USA.
    Background: We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the molecular and biochemical mechanism underlying the superior immunostimulatory property of IL-10 deficient DCs we performed proteomic analysis on protein profiles from Chlamydia-pulsed wild-type (WT) and IL-10(-/-) DCs to identify differentially expressed proteins with immunomodulatory properties.

    Results: The results showed that alpha enolase (ENO1), a metabolic enzyme involved in the last step of glycolysis was significantly upregulated in Chlamydia-pulsed IL-10(-/-) DCs compared to WT DCs. Read More

    Diagnostic Criteria in Intraepithelial Pagetoid Neoplasms: A Histopathologic Study and Evaluation of Select Features in Paget Disease, Bowen Disease, and Melanoma In Situ.
    Am J Dermatopathol 2017 Jun;39(6):419-427
    *Demonstrator at the Dermatology Department, Kasralainy Faculty of Medicine, Cairo, University, Egypt; †Visiting Research Fellow, Ackerman Academy of Dermatopathology, New York, NY; ‡Attending Dermatologist, Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangdong Provincial Dermatology Hospital, China; §Junior Specialist, Department of Dermatology, University of California, Irvine, CA; ¶Attending Dermatologist, Department of Dermatology, Jose R. Reyes Memorial Medical Center, Manila; ‖Medical Student, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ; #Professor of Biostatistics, Department of Biostatistics and Epidemiology, National Cancer Institute, Cairo University, Cairo, Egypt; **Dermatopathologist, Dermpath Diagnostics New York, Port Chester, NY; and ††Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC.
    Background: Paget disease, Bowen disease, and malignant melanoma in situ are intraepidermal neoplasms, characterized by the presence of pagetoid scatter of atypical cells in the epidermis. This study reviewed the frequency of select histologic criteria to validate their usefulness in the histologic distinction between these entities.

    Methods: One hundred forty-four specimens with the diagnosis of Bowen disease, 144 specimens with Paget disease (mammary and extramammary), and 144 specimens with malignant melanoma in situ were examined microscopically to define frequencies of select histologic criteria present in each disease. Read More

    Clinical, histological and therapeutic features of Bowen's disease.
    Rom J Morphol Embryol 2017 ;58(1):33-40
    Department of Plastic Surgery and Reconstructive Microsurgery, Emergency Clinical Hospital of Bucharest, Romania;
    Squamous cell carcinoma (SCC) in situ or Bowen's disease (BD) is a slowly progressive malignancy. However, cases of regression have been reported. Recent reviews cover only certain aspects of this disease; therefore, this paper's aim is to cover all the relevant aspects for medical practice, such as clinical, histological and therapeutic details. Read More

    Comparison of the incidence of skin cancers in patients on dialysis and after kidney transplantation.
    Postepy Dermatol Alergol 2017 Apr 13;34(2):138-142. Epub 2017 Apr 13.
    Department of Nephrology, Jagiellonian University Medical College, Krakow, Poland.
    Introduction: Kidney transplant (KTx) patients on immunosuppressive therapy are predisposed to the development of infections and cancers.

    Aim: To compare the incidence and type of malignant skin lesions in kidney transplant patients and the dialyzed population based on the initiated dermatologic screening.

    Material And Methods: The study included 598 patients: 486 kidney transplant recipients and 112 patients on maintenance dialysis. Read More

    Increased Risk for Meningococcal Disease among Men who have Sex with Men in the United States, 2012-2015.
    Clin Infect Dis 2017 May 13. Epub 2017 May 13.
    Centers for Disease Control and Prevention.
    Background: Several clusters of serogroup C meningococcal disease among men who have sex with men (MSM) have been reported in the United States in recent years. The epidemiology and risk of meningococcal disease among MSM is not well-described.

    Methods: All meningococcal disease cases among men aged 18-64 years reported to the National Notifiable Disease Surveillance System between January 2012 and June 2015 were reviewed. Read More

    In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using dynamic optical coherence tomography.
    J Eur Acad Dermatol Venereol 2017 May 14. Epub 2017 May 14.
    CMB/Collegium Medicum Berlin, Berlin, Germany.
    Background: A clear distinction between actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC) cannot reliably be made by clinical and dermoscopic evaluation alone. Dynamic optical coherence tomography (D-OCT) is a novel angiographic variant of OCT that allows for non-invasive, in vivo evaluation of the cutaneous microvascular morphology.

    Objective: To investigate the microvascular structures of AK, BD and invasive SCC using D-OCT in order to gain insights into the microvascular morphology of lesions in the spectrum of keratinocyte skin cancers. Read More

    Expression of PD-L1 in keratoacanthoma and different stages of progression in cutaneous squamous cell carcinoma.
    Cancer Immunol Immunother 2017 May 13. Epub 2017 May 13.
    Skin Cancer Center of the Department of Dermatology, St. Josef Hospital, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.
    Background: Programmed cell death 1 (PD-1) and its ligands (PD-L1) play a major role in the immune responses of a variety of cancers.

    Objectives: To investigate the expression of PD-L1 in different progression forms of cutaneous squamous cell carcinoma (cSCC) and keratoacanthoma (KA).

    Methods: We performed immunohistochemical staining of 21 KA, 26 actinic keratoses (AK), 20 Bowen´s diseases (BD), and 26 high-risk cSCC. Read More

    miR-21 Promotes Fibrogenesis in Peritoneal Dialysis.
    Am J Pathol 2017 Jul 9;187(7):1537-1550. Epub 2017 May 9.
    Wales Kidney Research Unit, Division of Infection and Immunity, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom. Electronic address:
    Peritoneal dialysis (PD) is a life-saving form of renal replacement therapy for those with end-stage kidney disease. Mesothelial cells (MCs) line the peritoneal cavity and help define peritoneal response to treatment-associated injury, a major reason for treatment failure. miRNAs are important regulators, but their roles in peritoneal fibrosis are largely unknown. Read More

    Selumetinib Plus Docetaxel Compared With Docetaxel Alone and Progression-Free Survival in Patients With KRAS-Mutant Advanced Non-Small Cell Lung Cancer: The SELECT-1 Randomized Clinical Trial.
    JAMA 2017 05;317(18):1844-1853
    Respiratory Oncology Unit, Department of Respiratory Diseases, University Hospital Katholieke Universiteit Leuven, Leuven, Belgium.
    Importance: There are no specifically approved targeted therapies for the most common genomically defined subset of non-small cell lung cancer (NSCLC), KRAS-mutant lung cancer.

    Objective: To compare efficacy of the mitogen-activated protein kinase kinase (MEK) inhibitor selumetinib + docetaxel with docetaxel alone as a second-line therapy for advanced KRAS-mutant NSCLC.

    Design, Setting, And Participants: Multinational, randomized clinical trial conducted at 202 sites across 25 countries from October 2013 through January 2016. Read More

    Patients with non-viral liver disease have a greater tumor burden and less curative treatment options when diagnosed with hepatocellular carcinoma.
    World J Gastroenterol 2017 Apr;23(15):2763-2770
    Waled Mohsen, Marcia Rodov, Emilia Prakoso, Barbara Charlton, David G Bowen, David J Koorey, Nicholas A Shackel, Geoffrey W McCaughan, Simone I Strasser, AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney NSW 2050, Australia.
    Aim: To assess the impact of underlying liver disease etiology on the presenting features and outcomes in a large cohort of patients with hepatocellular carcinoma (HCC).

    Methods: A prospective database of all patients with HCC was established from 1998 to March 2012. One thousand and seventy-eight patients were categorized into three groups, based on the etiology of their liver disease: hepatitis B virus (HBV), hepatitis C virus (HCV) and non-viral liver disease (NVLD). Read More

    Clonal Seborrheic Keratosis Versus Pagetoid Bowen Disease: Histopathology and Role of Adjunctive Markers.
    Am J Dermatopathol 2017 Jun;39(6):433-439
    *Department of Pathology, St. John's Medical College, Bengaluru, India; and †Department of Dermatopathology, Dermatologikum Hamburg, Hamburg, Germany.
    Clonal seborrheic keratosis (CSK) and pagetoid Bowen disease (squamous cell carcinoma in situ) (PBD) share similar histological features making it sometimes difficult to differentiate the 2. The study group included 29 and 13 cases of CSK and PBD, respectively. Both groups were examined histopathologically (suprabasal mitotic figures, broad rete ridges, crowding of nuclei, nuclear pleomorphism, necrotic keratinocytes, parakeratosis, and dermal inflammation) and immunohistochemically (CK10, Ki-67, and p16). Read More

    Pathogen-Specific Burden of Outpatient Diarrhea in Infants in Nepal: A Multisite Prospective Case-Control Study.
    J Pediatric Infect Dis Soc 2017 May 4. Epub 2017 May 4.
    Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia.
    Background.: Nonsevere diarrheal disease in Nepal represents a large burden of illness. Identification of the specific disease-causing pathogens will help target the appropriate control measures. Read More

    Comparative analysis of the predicted secretomes of Rosaceae scab pathogens Venturia inaequalis and V. pirina reveals expanded effector families and putative determinants of host range.
    BMC Genomics 2017 May 2;18(1):339. Epub 2017 May 2.
    The New Zealand Institute for Plant & Food Research Limited (PFR), Auckland, New Zealand.
    Background: Fungal plant pathogens belonging to the genus Venturia cause damaging scab diseases of members of the Rosaceae. In terms of economic impact, the most important of these are V. inaequalis, which infects apple, and V. Read More

    Expert consensus document: Echocardiography and lung ultrasonography for the assessment and management of acute heart failure.
    Nat Rev Cardiol 2017 Jul 27;14(7):427-440. Epub 2017 Apr 27.
    Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
    Echocardiography is increasingly recommended for the diagnosis and assessment of patients with severe cardiac disease, including acute heart failure. Although previously considered to be within the realm of cardiologists, the development of ultrasonography technology has led to the adoption of echocardiography by acute care clinicians across a range of specialties. Data from echocardiography and lung ultrasonography can be used to improve diagnostic accuracy, guide and monitor the response to interventions, and communicate important prognostic information in patients with acute heart failure. Read More

    A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines.
    Sci Rep 2017 Apr 21;7:46426. Epub 2017 Apr 21.
    Infectious Disease Research Institute, 1616 Eastlake Ave E., Seattle WA 98103, USA.
    Since 1997, highly pathogenic avian influenza viruses of the H5N1 subtype have been transmitted from avian hosts to humans. The severity of H5N1 infection in humans, as well as the sporadic nature of H5N1 outbreaks, both geographically and temporally, make generation of an effective vaccine a global public health priority. An effective H5N1 vaccine must ultimately provide protection against viruses from diverse clades. Read More

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