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    1 OF 88

    Clearance of human papillomavirus related anal condylomas after oral and endorectal multistrain probiotic supplementation in an HIV positive male: A case report.
    Medicine (Baltimore) 2018 Apr;97(16):e0329
    Department of Public Health and Infectious Diseases.
    Introduction: Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing. Biopsies of the anal mucosa led to the diagnosis of Bowen's disease and a subsequent pelvic magnetic resonance imaging (MRI) scan evidenced multiple reactive lymphoadenopathies and large intra-anal condylomas. The patient was treated with a complete excision of Bowen's lesion and with a 4 months course of supplementation with a high concentration multistrain probiotic formulation administered orally and by rectal instillation with the purpose to reduce local inflammation and to enhance local mucosal immunity. Read More

    Differential proteomic analysis of actinic keratosis, Bowen's disease and cutaneous squamous cell carcinoma by label-free LC-MS/MS.
    J Dermatol Sci 2018 Apr 10. Epub 2018 Apr 10.
    Centre for Translational Skin Research, The University of Sydney, Westmead, New South Wales, 2145, Australia; Department of Dermatology, Westmead Hospital, Westmead, New South Wales, 2145, Australia. Electronic address:
    Background: The boundaries between actinic keratosis (AK), Bowen's disease (BD), and cutaneous squamous cell carcinoma (cSCC) are sometimes not clear. Large-scale proteomic profiling studies of these lesions are also non-existent.

    Objective: To evaluate proteomic changes between normal epidermis, AK, BD and cSCC that could support a molecular classification and improve our understanding of disease progression. Read More

    Frequency of squamous cell carcinoma in situ (SCCIS) and SCC in re-excisions of biopsy-proven cutaneous SCCIS.
    Br J Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    University of Nottingham, School of Medicine Consultant Dermatologist and Mohs Surgeon Nottingham NHS Treatment Centre.
    Chang et al's important research letter has a headline figure of 3.3% of 726 biopsy proven squamous cell carcinoma in situ (SCCIS, Bowen's disease) being upstaged to SCC in subsequent excisions. This is in keeping with generally accepted figures of untreated SCCIS transformation to SCC of 3-5%. Read More

    Diagnostic accuracy of bioimpedance spectroscopy in patients with lymphedema: A retrospective cohort analysis.
    J Plast Reconstr Aesthet Surg 2018 Apr 9. Epub 2018 Apr 9.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA. Electronic address:
    Background: Bioimpedance spectroscopy (BIS) is used by healthcare specialists to diagnose lymphedema. BIS measures limb fluid content by assessing tissue resistance to the flow of electric current. However, there is debate regarding the validity of BIS in diagnosing early lymphedema. Read More

    Accuracy of dermoscopic criteria for the differentiation between superficial basal cell carcinoma and Bowen's disease.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Background: The dermoscopic features of superficial basal cell carcinoma (sBCC) and Bowen's disease (BD) have been extensively investigated and dermoscopy was shown to significantly improve their recognition. However, incorrectly diagnosed cases still exist, with a considerable number of sBCCs dermoscopically interpreted as BD. Our aim was to investigate the dermoscopic variability of sBCC and BD on different anatomic sites, to identify potent dermoscopic predictors for each diagnosis and to investigate the potential source of the inaccurate clinico-dermoscopic diagnosis of some sBCCs. Read More

    Laser-assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's Disease: a randomised intra-patient comparison between a continuous and a fractional ablative CO laser mode.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology, Ghent University Hospital, Belgium.
    Background: Laser-assisted photodynamic therapy is being explored as a method to enhance efficacy of photodynamic therapy (PDT).

    Objective: To compare a continuous (CL) and a fractional (FL) ablative CO laser-assisted methyl aminolevulinate PDT in the management of superficial basal cell carcinoma (sBCC) and Bowen's Disease (BD).

    Methods: Thirty treatment areas in fifteen patients with inoperable, histologically verified sBCC or BD, received CL or FL after intra-patient randomisation. Read More

    Pan Afr Med J 2018 2;29. Epub 2018 Jan 2.
    Service de Dermatologie, Hôpital Militaire Mohamed V, Rabat, Maroc.
    We here report the case of a16-year old patient, with no particular past medical history, presenting, with skin swelling at the level of the forefoot evolving for 02 years, at the Department of Dermatology. Clinical examination showed hard budding cutaneous mass painless on palpation covering the 2, the 3 and the 4, right toes, measuring 4 cm in large diameter. The remainder of the clinical examination was normal, without adenopathies. Read More

    An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.
    Cell 2018 Apr;173(2):400-416.e11
    Chan Soon-Shiong Institute of Molecular Medicine at Windber, Windber, PA 15963, USA. Electronic address:
    For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. Read More

    A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
    Cancer Cell 2018 Apr 2;33(4):690-705.e9. Epub 2018 Apr 2.
    Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:
    We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Read More

    The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.
    Cell Rep 2018 Apr;23(1):313-326.e5
    Urologic Oncology Branch, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA. Electronic address:
    Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Read More

    Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma.
    J Dermatol Sci 2018 Mar 16. Epub 2018 Mar 16.
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan. Electronic address:
    Background: Centrosomes contain two centrioles: a pre-existing mature centriole and a newly formed immature centriole. Each centriole is duplicated once within a cell cycle, which is crucial for proper centrosome duplication and cell division.

    Objective: To describe the centrosome duplication cycle in human epidermis, Bowen's disease (BD), and squamous cell carcinoma (SCC). Read More

    Pagetoid Bowen Disease Initially Misdiagnosed as Ectopic Extramammary Paget's Disease.
    Ann Dermatol 2018 Apr 21;30(2):218-221. Epub 2018 Feb 21.
    Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
    Pagetoid Bowen disease is a histological variant of Bowen disease which demonstrates large pale staining cells (pagetoid cells). It requires differential diagnosis from other cutaneous malignancies with similar patterns, such as extramammary Paget's disease (EMPD) and Pagetoid melanoma . Herein, we report a case of Pagetoid Bowen disease which was initially misdiagnosed as ectopic EMPD. Read More

    Psychological outcomes and surgical decisions after genetic testing in women newly diagnosed with breast cancer with and without a family history.
    Eur J Hum Genet 2018 Mar 30. Epub 2018 Mar 30.
    Familial Cancer Service, Westmead Hospital, Hawkesbury Road, Westmead, NSW, 2145, Australia.
    In patients with early breast cancer, personal and tumour characteristics other than family history are increasingly used to prompt genetic testing to guide women's cancer management (treatment-focused genetic testing, 'TFGT'). Women without a known strong family history of breast and/or ovarian may be more vulnerable to psychological sequelae arising from TFGT. We compared the impact of TFGT in women with (FH+) and without (FH-) a strong family history on psychological adjustment and surgical decisions. Read More

    Rotavirus surveillance in Pakistan during 2015-2016 reveals high prevalence of G12P[6].
    J Med Virol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.
    The G12 rotavirus genotype has emerged globally since their first detection in 1987 from the Philippines; however it remains a rare cause of gastroenteritis in Pakistan. Rotavirus surveillance conducted during 2015-2016, assessed 3446 children <5 years hospitalized for gastroenteritis and found 802 (23.2%) positive on ELISA. Read More

    Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!
    Dermatology 2017 22;233(6):482-488. Epub 2018 Mar 22.
    Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
    Background: Lower limbs represent an uncommon location for basal cell carcinoma (BCC) and only few reports have described dermoscopic features of BCC in this body site. Since BCCs of the lower limbs frequently display nonclassic BCC dermoscopic criteria, they can simulate other benign or malignant lesions.

    Objective: Our aim was to describe the dermoscopic features of BCC located on lower limbs and to define which criteria were more associated with their benign- or malignant-looking appearance. Read More

    Phototherapy with Light Emitting Diodes: Treating a Broad Range of Medical and Aesthetic Conditions in Dermatology.
    J Clin Aesthet Dermatol 2018 Feb 1;11(2):21-27. Epub 2018 Feb 1.
    Dr. Ablon is with the Ablon Skin Institute and Research Center in Manhattan Beach, California.
    Within the field of dermatology, advances in the use of light emitting diodes (LEDs) have led to their clinical application for a variety of medical and cosmetic uses. Of note, one phototherapy device has demonstrated beneficial effects over a range of clinical applications (Omnilux™; GlobalMed Technologies, Glen Ellen, California). The study included a literature review of published studies. Read More

    Glucose Monitoring Dermopathy.
    Skinmed 2018 1;16(1):74-75. Epub 2018 Feb 1.
    Division of Dermatology, Department of Medicine and Department of Pediatrics, Cooper Medical School of Rowan University, Marlton, NJ;
    A 75-year-old man had been monitoring his glucose using a blood glucose monitoring system at the same body site for at least 20 years (>7300 needlesticks). The asymptomatic skin lesion had been present for many years. He used the same site because it hurt less than the fingers and bled well. Read More

    Use of National Syphilis Surveillance Data to Develop a Congenital Syphilis Prevention Cascade and Estimate the Number of Potential Congenital Syphilis Cases Averted.
    Sex Transm Dis 2018 Mar 14. Epub 2018 Mar 14.
    Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
    Background: Recent increases in reported congenital syphilis have led to an urgent need to identify interventions that will have the greatest impact on congenital syphilis prevention. We sought to create a congenital syphilis prevention cascade using national syphilis surveillance data to (1) estimate the proportion of potential congenital syphilis cases averted with current prevention efforts, and (2) develop a classification framework to better describe why reported cases were not averted.

    Methods: We reviewed national syphilis and congenital syphilis case report data from 2016, including pregnancy status of all reported female syphilis cases and data on prenatal care, testing, and treatment status of mothers of reported congenital syphilis cases to derive estimates of the proportion of pregnant women with syphilis who received prenatal care, syphilis testing, and adequate syphilis treatment at least 30 days prior to delivery, as well as the proportion of potential congenital syphilis cases averted. Read More

    T follicular helper-like cells contribute to skin fibrosis.
    Sci Transl Med 2018 Mar;10(431)
    Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA.
    Systemic sclerosis (SSc) is a debilitating inflammatory and fibrotic disease that affects the skin and internal organs. Although the pathophysiology of SSc remains poorly characterized, mononuclear cells, mainly macrophages and T cells, have been implicated in inflammation and fibrosis. Inducible costimulator (ICOS), which is expressed on a subset of memory T helper (T) and T follicular helper (T) cells, has been shown to be increased in SSc and associated with disease pathology. Read More

    A Multivariable Prediction Model for Mortality in Individuals Admitted for Heart Failure.
    J Am Geriatr Soc 2018 Mar 6. Epub 2018 Mar 6.
    Center of Innovation in Long-term Services and Supports, Providence Veterans Affairs Medical Center, Providence, Rhode Island.
    Objectives: To derive and validate a 30-day mortality clinical prediction rule for heart failure based on admission data and prior healthcare usage. A secondary objective was to determine the discriminatory function for mortality at 1 and 2 years.

    Design: Observational cohort. Read More

    Hereditary cancer gene panel test reports: wide heterogeneity suggests need for standardization.
    Genet Med 2018 Mar 1. Epub 2018 Mar 1.
    Department of Bioethics and Humanities, University of Washington, Seattle, Washington, USA.
    PurposeLaboratory-generated genomic test reports are used to convey complex, and frequently multivariant or uncertain, information about disease risk to medical genetics professionals as well as to nonspecialist clinicians, patients, and family members. However, few guidelines exist to guide the content and format of genomic test reports, and little is known about variation in current reporting practices.MethodsWe conducted a structured content analysis of hereditary cancer gene panel test reports obtained from 16 United States-based CLIA-certified laboratories, including reports describing a variant of uncertain significance (VUS) only and reports with both a VUS and pathogenic or likely pathogenic (P/LP) test result. Read More

    Cutaneous horn: A mask to underlying malignancy.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S87-S90
    Department of Oral Pathology, Manubhai Patel Dental College, Vadodara, Gujarat, India.
    Cutaneous horns () are uncommon lesions consisting of keratotic material resembling that of an animal horn. It is a conical- or cylindrical-shaped excessive hyperkeratosis of variable size ranging from few millimeters to several centimeters with a variable in size and shape, such as cylindrical, conical, pointed, transversely or longitudinally corrugated, or curved like a ram's horn. The lesions typically occur in sun-exposed areas, particularly the face, ear, nose, forearms and dorsum of hands. Read More

    Multi-state Syphilis Outbreak among American Indians, 2013-2015.
    Sex Transm Dis 2018 Feb 13. Epub 2018 Feb 13.
    Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
    This article summarizes a multi-state outbreak of heterosexual syphilis, including 134 cases of syphilis in adults and adolescents and at least two cases of congenital syphilis, which occurred on an American Indian reservation in the United States during 2013-2015. In addition to providing salient details about the outbreak, the article seeks to document the case-finding and treatment activities undertaken, their relative success or failure, and the lessons learned from a coordinated, multiagency response. Of 134 adult cases of syphilis, 40% were identified by enhanced, interagency contact tracing and partner services; 26% through symptomatic testing; and 16% through screening of asymptomatic individuals as the result of an electronic medical record (EMR) screening prompt. Read More

    Cryosurgery + 5% 5-Fluorouracil for Treatment of Superficial Basal Cell Carcinoma and Bowen's Disease.
    J Cutan Med Surg 2018 Feb 1:1203475418758973. Epub 2018 Feb 1.
    2 Department of Medicine, Division of Dermatology, University of Alberta, Edmonton, AB, Canada.
    Background: Superficial basal cell carcinoma (sBCC) and squamous cell carcinoma in situ (SCCis) are 2 types of nonmelanoma skin cancers (NMSCs) that are amenable to treatment with topical 5-fluorouracil, cryosurgery, or topical imiquimod, among other destructive and surgical modalities. There are few studies examining the effectiveness of combination therapy with 5% 5-fluorouracil and cryosurgery for the treatment of sBCC and SCCis.

    Objectives: Our objective was to study the clinical cure rate achieved with the regimen of cryosurgery and a 3-week course of 5% 5-fluorouracil in the treatment of biopsy-proven sBCC and SCCis. Read More

    IMMUNOHISTOCHEMICAL INVESTIGATION OF PREDICTORS OF RESPONSE OR AGRESSIVITY OF BOWEN DISEASE AFTER PHOTODYNAMIC THERAPY.
    Photodiagnosis Photodyn Ther 2018 Feb 15. Epub 2018 Feb 15.
    Department of Dermatology, Hospital Central de la Cruz Roja, Madrid, Spain.
    Background: Photodynamic therapy (PDT) is a good option for the treatment of Bowen's disease (BD) but, BD occasionally develops into a squamous cell carcinoma (SCC) after PDT.

    Objective: Find predictors of aggressiveness of BD after PDT METHODS: Two biopsies of patients with BD treated with PDT with progression to SCC within three months were selected for immunohistochemical (IHC) studies. Conventional PDT was applied. Read More

    West Nile and St. Louis encephalitis viral genetic determinants of avian host competence.
    PLoS Negl Trop Dis 2018 Feb 15;12(2):e0006302. Epub 2018 Feb 15.
    Division of Vector-Borne Diseases, Arboviral Disease Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America.
    West Nile virus (WNV) and St. Louis encephalitis (SLEV) virus are enzootically maintained in North America in cycles involving the same mosquito vectors and similar avian hosts. However, these viruses exhibit dissimilar viremia and virulence phenotypes in birds: WNV is associated with high magnitude viremias that can result in mortality in certain species such as American crows (AMCRs, Corvus brachyrhynchos) whereas SLEV infection yields lower viremias that have not been associated with avian mortality. Read More

    The role of reflectance confocal microscopy in a case of Bowen's disease difficult to diagnose.
    Dermatol Pract Concept 2018 Jan 31;8(1):63-65. Epub 2018 Jan 31.
    Department of Dermatology, Faculty of Medicine, University of Ege, Izmir, Turkey.
    There have been limited reports describing reflectance confocal microscopy (RCM) features of Bowen's disease (BD). Herein, we describe the RCM features of a pigmented BD with atypical dermoscopic features, mimicking a melanoma. This case highlights the importance of RCM in a challenging BD. Read More

    Iron-Insensitive Quantitative Assessment of Subcortical Gray Matter Demyelination in Multiple Sclerosis Using the Macromolecular Proton Fraction.
    AJNR Am J Neuroradiol 2018 Apr 8;39(4):618-625. Epub 2018 Feb 8.
    Multiple Sclerosis Center (P.R., A.M., P.Q., L.K.J.H., B.G., J.D.B.), Swedish Neuroscience Institute, Seattle, Washington.
    Background And Purpose: Fast macromolecular proton fraction mapping is a recent quantitative MR imaging method for myelin assessment. The objectives of this study were to evaluate the macromolecular proton fraction as a measure of demyelination in subcortical GM structures in multiple sclerosis and assess a potential relationship between demyelination and excess iron deposition using the macromolecular proton fraction and T2* mapping.

    Materials And Methods: Macromolecular proton fraction and T2* maps were obtained from 12 healthy controls, 18 patients with relapsing-remitting MS, and 12 patients with secondary-progressive MS using 3T MR imaging. Read More

    The Integrated Genomic Landscape of Thymic Epithelial Tumors.
    Cancer Cell 2018 Feb;33(2):244-258.e10
    Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA. Electronic address:
    Thymic epithelial tumors (TETs) are one of the rarest adult malignancies. Among TETs, thymoma is the most predominant, characterized by a unique association with autoimmune diseases, followed by thymic carcinoma, which is less common but more clinically aggressive. Using multi-platform omics analyses on 117 TETs, we define four subtypes of these tumors defined by genomic hallmarks and an association with survival and World Health Organization histological subtype. Read More

    Quantum Language of MicroRNA: Application for New Cancer Therapeutic Targets.
    Methods Mol Biol 2018 ;1733:145-157
    Retroviral Genetics Group, Pharmaco-MicroRNA Genomics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan.
    MicroRNA (miRNA) is the noncoding gene: therefore, the miRNA gene inheritably controls protein gene expression through transcriptional and post-transcriptional levels. Aberrant expression of miRNA genes causes various human diseases, especially cancers. Although cancer is a complex disease, cancer/miRNA implication has yet been grasped from the perspective of miRNA profile in bed side. Read More

    Toward consensus reporting of radiation-induced liver toxicity in the treatment of primary liver malignancies: Defining clinically relevant endpoints.
    Pract Radiat Oncol 2017 Nov 4. Epub 2017 Nov 4.
    Department of Radiation Oncology, University of Washington, Seattle, Washington. Electronic address:
    Background: Our purpose was to define the most clinically relevant "nonclassic" radiation-induced liver disease (RILD) endpoints in cirrhotic patients receiving stereotactic body radiation therapy or proton beam therapy for primary liver cancer.

    Methods And Materials: We retrospectively collected pretreatment, detailed toxicity (≤6 months posttreatment), and outcomes data from 48 patients. Deaths were examined for association with RILD. Read More

    Association between empirically derived dietary patterns with blood lipids, fasting blood glucose and blood pressure in adults - the India migration study.
    Nutr J 2018 Feb 8;17(1):15. Epub 2018 Feb 8.
    London School of Hygiene and Tropical Medicine, London, UK.
    Background: Dietary patterns (DPs) in India are heterogenous. To date, data on association of indigenous DPs in India with risk factors of nutrition-related noncommunicable diseases (cardiovascular disease and diabetes), leading causes of premature death and disability, are limited. We aimed to evaluate the associations of empirically-derived DPs with blood lipids, fasting glucose and blood pressure levels in an adult Indian population recruited across four geographical regions of India. Read More

    A synthesis of the world's guidelines on photodynamic therapy for non-melanoma skin cancer.
    G Ital Dermatol Venereol 2018 Feb 7. Epub 2018 Feb 7.
    Department of Dermatology, Stirling Community Hospital, Stirling, UK -
    Photodynamic therapy (PDT), using topically administered photosensitizing agents, is widely approved as a treatment for certain nonmelanoma skin cancers. As a tissue-sparing non-surgical modality, there is great potential for PDT to enhance the choice of therapies available to treat, and potentially prevent, skin cancer. Treatment-specific guidelines have assessed the evidence for various photosensitizing agents and light sources, dosimetry, and evaluate reported adverse effects. Read More

    Disparities in severe shigellosis among adults - Foodborne diseases active surveillance network, 2002-2014.
    BMC Public Health 2018 02 7;18(1):221. Epub 2018 Feb 7.
    Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30333, USA.
    Background: Shigella causes approximately 500,000 illnesses, 6000 hospitalizations, and 40 deaths in the United States annually, but incidence and populations at risk for severe shigellosis among adults are unclear. This study describes severe shigellosis among US adults.

    Methods: We analyzed Foodborne Diseases Active Surveillance Network data for infections caused by Shigella among adults ≥18 years old during 2002-2014. Read More

    Photodynamic Therapy Activated by Intense Pulsed Light in the Treatment of Nonmelanoma Skin Cancer.
    Biomedicines 2018 Feb 7;6(1). Epub 2018 Feb 7.
    Skin Center, Dermo-Aesthetic Lasers Centers, 67051 Avezzano, Italy.
    Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) has proven to be a highly effective conservative method for the treatment of actinic keratosis (AK), Bowen's disease (BD), and superficial basal cell carcinoma (sBCC). PDT is traditionally performed in association with broad-spectrum continuous-wave light sources, such as red or blue light. Recently, intense pulsed light (IPL) devices have been investigated as an alternative light source for PDT in the treatment of nonmelanoma skin cancers (NMSC). Read More

    Raising the stakes: Loss of efflux-pump regulation decreases meropenem susceptibility in Burkholderia pseudomallei.
    Clin Infect Dis 2018 Jan 31. Epub 2018 Jan 31.
    Global and Tropical Health Division, Menzies School of Health Research, Tiwi, Northern Territory, Australia.
    Background: Burkholderia pseudomallei, the causative agent of the high-mortality disease melioidosis, is a Gram-negative bacterium that is naturally resistant to many antibiotics. There is no vaccine for melioidosis, and effective eradication is reliant on biphasic and prolonged antibiotic administration. The carbapenem drug, meropenem, is the current gold-standard option for treating severe melioidosis. Read More

    The NICE-GUT trial protocol: a randomised, placebo controlled trial of oral nitazoxanide for the empiric treatment of acute gastroenteritis among Australian Aboriginal children.
    BMJ Open 2018 02 1;8(2):e019632. Epub 2018 Feb 1.
    Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Subiaco, Australia.
    Introduction: Diarrhoeal disease is the second leading cause of death in children under 5 years globally, killing 525 000 annually. Australian Aboriginal and Torres Strait Islander (hereafter Aboriginal) children suffer a high burden of disease. Randomised trials in other populations suggest nitazoxanide accelerates recovery for children with , amoebiasis, gastroenteritis, as well as in cases where no enteropathogens are found. Read More

    Zoonotic pathogens from feral swine that pose a significant threat to public health.
    Transbound Emerg Dis 2018 Jan 31. Epub 2018 Jan 31.
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
    The natural fecundity of suids, great ability to adapt to new habitats and desire for local hunting opportunities leading to translocation of feral pigs to regions where they are not yet established have all been instrumental in the home range expansion of feral swine. Feral swine populations in the United States continue to expand, wreaking havoc on agricultural lands, further compromising threatened and endangered species, and posing a microbiological threat to humans, domestic livestock and companion animals. This manuscript thoroughly reviews zoonotic diseases of concern including brucellosis, bovine tuberculosis, leptospirosis, enteric pathogens, both Salmonella spp. Read More

    Clinical experience of ingenol mebutate gel for the treatment of Bowen's disease.
    J Dermatol 2018 Jan 31. Epub 2018 Jan 31.
    Department of Dermatology, Korea University College of Medicine, Seoul, Korea.
    There are only a few anecdotal case reports about Bowen's disease (BD) treated with ingenol mebutate (IM) gel but no clinical study has been published yet. The aim of this study was to evaluate the effectiveness of IM gel in the treatment of BD and to observe the therapeutic efficacy of IM alone or IM with ablative fractional laser pretreatment. Nineteen patients with BD or squamous cell carcinoma in situ confirmed by skin biopsy were enrolled. Read More

    Nutrition and Cardiovascular Disease-an Update.
    Curr Atheroscler Rep 2018 Jan 30;20(2). Epub 2018 Jan 30.
    Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA, 16802, USA.
    Purpose Of Review: This review summarizes recent developments in nutrition and cardiovascular disease (CVD) prevention.

    Recent Findings: Contemporary dietary guidance recommends healthy dietary patterns with emphasis on food-based recommendations because the totality of the diet (i.e. Read More

    Right ventricular involution: What can we learn from nature's model of compensated hypertrophy?
    J Thorac Cardiovasc Surg 2018 May 19;155(5):2024-2028.e1. Epub 2017 Dec 19.
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah. Electronic address:
    Background: Right ventricular (RV) failure (RVF) is a vexing problem facing patients with various disease processes and carries a high mortality. RVF is a poorly understood phenomenon with limited treatment options. In mammalian fetal circulation, the right ventricle is the systemic ventricle. Read More

    Implementing Key Drivers for Diabetes Self-Management Education and Support Programs: Early Outcomes, Activities, Facilitators, and Barriers.
    Prev Chronic Dis 2018 Jan 25;15:E15. Epub 2018 Jan 25.
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.

    Pulsed-dye laser therapy for carcinoma in situ of the penis.
    Br J Dermatol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
    Carcinoma in situ (CIS) of the penis is a precancerous condition with a 5 to 10% risk for progression into an invasive penile squamous cell carcinoma (SCC) . Clinical variants of genital CIS encompass bowenoid papulosis, erythroplasia of Queyrat and Bowen's disease. Treatment options of penile CIS include topical application of 5-fluorouracil (5-FU) or imiquimod, photodynamic therapy (PDT), ablative laser therapy, cryotherapy and surgery . Read More

    Surveillance for Tick-Borne Viruses Near the Location of a Fatal Human Case of Bourbon Virus (Family Orthomyxoviridae: Genus Thogotovirus) in Eastern Kansas, 2015.
    J Med Entomol 2018 Jan 20. Epub 2018 Jan 20.
    College of Veterinary Medicine, Kansas State University, Manhattan, KS.
    Bourbon virus (Family Orthomyxoviridae: Genus Thogotovirus) was first isolated from a human case-patient residing in Bourbon County, Kansas, who subsequently died. Before becoming ill in late spring of 2014, the patient reported several tick bites. In response, we initiated tick surveillance in Bourbon County and adjacent southern Linn County during spring and summer of 2015. Read More

    Development of a Multiplexed Microsphere PCR for Culture-Free Detection and Gram-Typing of Bacteria in Human Blood Samples.
    ACS Infect Dis 2018 Jan 31. Epub 2018 Jan 31.
    Division of Immunology, QIMR Berghofer Medical Research Institute , 300 Herston Road, Brisbane, Queensland 4006, Australia.
    Bloodstream infection is a significant clinical problem, particularly in vulnerable patient groups such as those undergoing chemotherapy and bone marrow transplantation. Clinical diagnostics for suspected bloodstream infection remain centered around blood culture (highly variable timing, in the order of hours to days to become positive), and empiric use of broad-spectrum antibiotics is therefore employed for patients presenting with febrile neutropenia. Gram-typing provides the first opportunity to target therapy (e. Read More

    Yersinia pestis Survival and Replication in Potential Ameba Reservoir.
    Emerg Infect Dis 2018 Feb;24(2):294-302
    Plague ecology is characterized by sporadic epizootics, then periods of dormancy. Building evidence suggests environmentally ubiquitous amebae act as feral macrophages and hosts to many intracellular pathogens. We conducted environmental genetic surveys and laboratory co-culture infection experiments to assess whether plague bacteria were resistant to digestion by 5 environmental ameba species. Read More

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