5,299 results match your criteria Bowen Disease

Bowen disease on multiple digits.

Indian J Dermatol Venereol Leprol 2022 May 9:1-2. Epub 2022 May 9.

Department of Dermatology and Venerology, Peking University First Hospital, Beijing China.

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Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection.

PLoS Pathog 2022 May 19;18(5):e1010437. Epub 2022 May 19.

Department of Biochemistry and Molecular Biology, Department of Biology, Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, United States of America.

Herpes simplex virus (HSV) causes chronic infection in the human host, characterized by self-limited episodes of mucosal shedding and lesional disease, with latent infection of neuronal ganglia. The epidemiology of genital herpes has undergone a significant transformation over the past two decades, with the emergence of HSV-1 as a leading cause of first-episode genital herpes in many countries. Though dsDNA viruses are not expected to mutate quickly, it is not yet known to what degree the HSV-1 viral population in a natural host adapts over time, or how often viral population variants are transmitted between hosts. Read More

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A double-blind, placebo-controlled, single-ascending-dose intravenous infusion study of rHIgM22 in subjects with multiple sclerosis immediately following a relapse.

Mult Scler J Exp Transl Clin 2022 Apr-Jun;8(2):20552173221091475. Epub 2022 Apr 26.

ONO Pharma, Rockville, MD.

Background: Recombinant human immunoglobulin M22 (rHIgM22) has promoted remyelination in animal models and was well tolerated in people with clinically stable multiple sclerosis.

Objective: Safety/tolerability of a single rHIgM22 dose was investigated following an acute relapse and to determine whether this enhanced CNS/CSF concentrations.

Methods: Adults (N = 27) with acute relapse were assigned to rHIgM22 (0. Read More

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(In)visible and (Un)heard? Older Adults as Guests on COVID-Related Political Talk Shows in Germany.

Innov Aging 2022 2;6(2):igac009. Epub 2022 Mar 2.

Department of Psychology, MSB Medical School Berlin, Berlin, Germany.

Background And Objectives: The coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected older adults. Despite calls to include older people in societal decision making, the extent to which older adults have participated in the pandemic-related public debate is unknown. This study investigated older adults' (65+ years) voice and visibility as guests on political talk shows as an important arena of public debate. Read More

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Muco-Cutaneous Infections in HIV Infected Children at a Nigerian Tertiary Hospital.

West Afr J Med 2022 Apr;39(4):362-368

Department of Paediatrics and Child Health, UniOsun Teaching Hospital, Osogbo, Osun State, Nigeria.

Background: Studies on mucous infections in HIV infected children are sparse. Cutaneous infections though common, vary in pattern and prevalence over time and location.

Objectives: To provide updates on the prevalence and pattern of muco-cutaneous infections among HIV infected children attending a Nigerian tertiary hospital and identify neglected muco-cutaneous infections. Read More

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Health equity in the implementation of genomics and precision medicine: A public health imperative.

Genet Med 2022 Apr 28. Epub 2022 Apr 28.

Office of Science, Centers for Disease Control and Prevention, Atlanta, GA.

Recent reviews have emphasized the need for a health equity agenda in genomics research. To ensure that genomic discoveries can lead to improved health outcomes for all segments of the population, a health equity agenda needs to go beyond research studies. Advances in genomics and precision medicine have led to an increasing number of evidence-based applications that can reduce morbidity and mortality for millions of people (tier 1). Read More

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Bowen disease on the dorsum of the foot associated with human papillomavirus type 16.

J Med Invest 2022 ;69(1.2):152-154

Department of Dermatology, Tokushima University Graduate School of BioMedical Science, Tokushima, Japan.

A 94 years old Japanese female was presented to our hospital with a skin lesion on her left foot. A physical examination found a markedly hyperkeratotic reddish-brown plaque, measuring 3 cm in diameter. A biopsy specimen showed prominent papillomatosis, hyperkeratosis, and atypical keratinocytes throughout the epidermis. Read More

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Incidence and Prevalence of Skin Cancers in South Korea from 2008 to 2016: A Nation-Wide Population Based Study.

Ann Dermatol 2022 Apr 24;34(2):105-109. Epub 2022 Mar 24.

Department of Dermatology, Dankook University College of Medicine, Cheonan, Korea.

Background: In South Korea, there have been few nationwide epidemiologic studies about premalignant actinic keratosis (AK), squamous cell carcinoma (Bowen's disease), nonmelanoma skin cancer (NMSC), malignant melanoma of the skin (MM), Kaposi's sarcoma (KS), connective and soft tissue cancers, or mycosis fungoides (MF).

Objective: Using a nationwide population-based study, we attempted to measure the incidence and the prevalence of the above-mentioned tumors in South Korea.

Methods: The database we used included all claims in the Korean National Health Insurance program and the Korean Medical Aid program from 2008 to 2016. Read More

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A systematic framework for prioritising burden of disease data required for vaccine development and implementation: the case for group A streptococcal diseases.

Clin Infect Dis 2022 Apr 19. Epub 2022 Apr 19.

CDC Foundation, Atlanta, Georgia, USA.

Vaccine development and implementation decisions need to be guided by accurate and robust burden of disease data. We developed an innovative systematic framework outlining the properties of such data that are needed to advance vaccine development and evaluation, and prioritise research and surveillance activities. We focus on four objectives: advocacy; regulatory oversight and licensure; policy and post-licensure evaluation; and post-licensure financing and identify key stakeholders and specific requirements for burden of disease data aligned with each objective. Read More

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Measurements of illuminance in simulated daylight photodynamic therapy.

Photodermatol Photoimmunol Photomed 2022 Apr 19. Epub 2022 Apr 19.

Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Simulated daylight photodynamic therapy (SDL-PDT) is a new treatment alternative for actinic keratosis. The aim of this study was to show how the illuminance that reaches the target skin area during SDL-PDT depends on the spatial positioning of the patient.

Methods: In this technical validation study, illuminance from the SDL-PDT system IndoorLux© was measured at different angles, directions, and distances from the light sources corresponding to potential target skin areas. Read More

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Digital Image Analysis-Based Evaluation of Claudin-1 and Claudin-7 Delocalization in Cutaneous Squamous Cell Carcinoma and in Its Precancerous State.

J Oncol 2022 6;2022:2750193. Epub 2022 Apr 6.

Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

Accumulating evidence has revealed that delocalization of the transmembrane proteins, Claudin-1 and Claudin-7, to the cytoplasm and/or nucleus occurs in various tumors. However, their subcellular distribution in terms of the membrane, cytoplasm, and nucleus and relationship with signaling pathways have not been elucidated during carcinogenesis. We first determined the expression of these proteins in the membrane, cytoplasm, and nucleus using ImageJ software and automatically collected the immunohistochemical quantification of dysplasia (actinic keratosis (AK)), carcinoma in situ (CIS; Bowen's disease (BD)), and invasive cutaneous squamous cell carcinoma (SCC) for digital image analysis (DIA). Read More

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Radiotherapy, Utilizing Volumetric Modulated Arc Therapy, for Extensive Skin Field Cancerization: A Retrospective Case Series Assessing Efficacy, Safety, and Cosmetic Outcomes at 12 Months After Treatment.

Case Rep Dermatol 2022 Jan-Apr;14(1):31-38. Epub 2022 Mar 10.

Specialist Connect Services, Brisbane, Queensland, Australia.

Extensive Skin Field Cancerization (ESFC) describes multiple actinic keratoses, with and without keratinocyte skin cancers. These areas are characterised by dysplastic keratoses, are prone to new malignancies, involve significant morbidity, have a poor cosmetic appearance, and impact negatively on quality of life. Available topical field therapies have limited durability of efficacy. Read More

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Risk-Factors for Exposure Associated With SARS-CoV-2 Detection After Recent Known or Potential COVID-19 Exposures Among Patients Seeking Medical Care at a Large Urban, Public Hospital in Fulton County, Georgia - A Cross-Sectional Investigation.

Front Public Health 2022 24;10:809356. Epub 2022 Mar 24.

Centers for Disease Control and Prevention, Atlanta, GA, United States.

We aimed to describe frequency of COVID-19 exposure risk factors among patients presenting for medical care at an urban, public hospital serving mostly uninsured/Medicare/Medicaid clients and risk factors associated with SARS-CoV-2 infection. Consenting, adult patients seeking care at a public hospital from August to November 2020 were enrolled in this cross-sectional investigation. Saliva, anterior nasal and nasopharyngeal swabs were collected and tested for SARS-CoV-2 using RT-PCR. Read More

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Prediction of disability-free survival in healthy older people.

Geroscience 2022 Apr 14. Epub 2022 Apr 14.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, Victoria, 3004, Australia.

Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4. Read More

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COVID-19 severity from Omicron and Delta SARS-CoV-2 variants.

Influenza Other Respir Viruses 2022 Apr 13. Epub 2022 Apr 13.

Division of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

The Omicron variant of SARS-CoV-2 achieved worldwide dominance in late 2021. Early work suggests that infections caused by the Omicron variant may be less severe than those caused by the Delta variant. We sought to compare clinical outcomes of infections caused by these two strains, confirmed by whole genome sequencing, over a short period of time, from respiratory samples collected from SARS-CoV-2 positive patients at a large medical center. Read More

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Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90.

Sci Rep 2022 Apr 12;12(1):6117. Epub 2022 Apr 12.

Institute for Systems Biology, Seattle, WA, USA.

Genetics play an important role in late-onset Alzheimer's Disease (AD) etiology and dozens of genetic variants have been implicated in AD risk through large-scale GWAS meta-analyses. However, the precise mechanistic effects of most of these variants have yet to be determined. Deeply phenotyped cohort data can reveal physiological changes associated with genetic risk for AD across an age spectrum that may provide clues to the biology of the disease. Read More

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Assessment of agreement using the equine glandular gastric disease grading system in 84 cases.

Vet Med Sci 2022 Apr 12. Epub 2022 Apr 12.

School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.

Introduction: Equine glandular gastric disease (EGGD) is a common condition causing signs of gastric pain although lesions are highly variable in their appearance. The only definitive method to diagnose EGGD ante-mortem is gastroscopy. The current recommended method for describing these lesions is the European College of Equine Internal Medicine (ECEIM) guidelines; however, repeatability between users is variable. Read More

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Effect of a Home-Based, Walking Exercise Behavior Change Intervention vs Usual Care on Walking in Adults With Peripheral Artery Disease: The MOSAIC Randomized Clinical Trial.

JAMA 2022 04;327(14):1344-1355

Department of Population Health Sciences, School of Life Course & Population Sciences, King's College London, London, United Kingdom.

Importance: Home-based walking exercise interventions are recommended for people with peripheral artery disease (PAD), but evidence of their efficacy has been mixed.

Objective: To investigate the effect of a home-based, walking exercise behavior change intervention delivered by physical therapists in adults with PAD and intermittent claudication compared with usual care.

Design, Setting, And Participants: Multicenter randomized clinical trial including 190 adults with PAD and intermittent claudication in 6 hospitals in the United Kingdom between January 2018 and March 2020; final follow-up was September 8, 2020. Read More

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Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice.

Sci Transl Med 2022 Apr 12:eabn1252. Epub 2022 Apr 12.

Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.

New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here we used a cell-free expression workflow to rapidly screen and optimize constructs containing multiple computationally designed miniprotein inhibitors of SARS-CoV-2. We found the broadest efficacy with a homo-trimeric version of the 75-residue angiotensin converting enzyme 2 (ACE2) mimic AHB2 (TRI2-2) designed to geometrically match the trimeric spike architecture. Read More

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Sources of dietary gluten in the first two years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: TEDDY study.

Am J Clin Nutr 2022 Apr 8. Epub 2022 Apr 8.

Department of Clinical Sciences, Lund University, Malmö Sweden.

Background: High gluten intake is associated with increased risk of celiac disease (CD) in children at genetic risk.

Objectives: To investigate if different dietary gluten sources up to age two years confer different risks of celiac disease autoimmunity (CDA) and CD in children at genetic risk.

Design: Three-day food records were collected at age six, nine, 12, 18 and 24 months from 2088 Swedish genetically at-risk children participating in a 15-year follow-up cohort study on type 1 diabetes and celiac disease. Read More

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Prevalence of Merkel Cell Polyomavirus in Normal and Lesional Skin: A Systematic Review and Meta-Analysis.

Front Oncol 2022 22;12:868781. Epub 2022 Mar 22.

Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, China.

The prevalence of Merkel cell polyomavirus(MCPyV) in Merkel cell carcinoma(MCC) and non-MCC skin lesions and its possible role in the etiology of other skin diseases remain controversial. To systematically assess the association between MCPyV infection and MCC, non-MCC skin lesions, and normal skin. For this systematic review and meta-analysis, a comprehensive search for eligible studies was conducted using Medline Ovid, Pubmed, Web of Science, and the Cochrane CENTRAL databases until August 2021; references were searched to identify additional studies. Read More

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Fluorescence kinetics study of twice laser irradiation based HpD-PDT for nonmelanoma skin cancer.

Lasers Surg Med 2022 Apr 7. Epub 2022 Apr 7.

Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: Hematoporphyrine injection (HpD)-based photodynamic therapy (HpD-PDT) has emerged as a promising cancer therapy. However, its tumor-targeting ability and metabolokinetics in nonmelanoma skin cancer (NMSC) have not been well explored. Importantly, photodynamic diagnosis is widely used for cancer lesion assessment and positioning to ensure effective therapy, while the photosensitizer metabolic kinetics study is utilized for biosafety assessment and light-protection instruction. Read More

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Missing Piece Study protocol: prospective surveillance to determine the epidemiology of group A streptococcal pharyngitis and impetigo in remote Western Australia.

BMJ Open 2022 Apr 6;12(4):e057296. Epub 2022 Apr 6.

Faculty of Health and Medical Sciences, The University of Western Australia, Perth, Western Australia, Australia.

Introduction: Group A β-haemolytic Streptococcus (GAS), a Gram-positive bacterium, causes skin, mucosal and systemic infections. Repeated GAS infections can lead to autoimmune diseases acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Aboriginal and Torres Strait Islander peoples in Australia have the highest rates of ARF and RHD in the world. Read More

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Malaria Parasitaemia and its Associated Factors among Febrile Children in a Tertiary Hospital in Southwest Nigeria.

West Afr J Med 2022 Mar;39(3):214-319

Department of Medicine, College of Health Sciences, Bowen University Teaching Hospital, Ogbomoso, Oyo State, Nigeria.

Background: Malaria is a parasitic disease of public health concern especially among children because of their vulnerability. Objective: The study sought to evaluate the prevalence and severity of malaria and to assess the factors associated with malaria parasitaemia among children.

Methods: This was a hospital-based cross-sectional observation study. Read More

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New insights into the genetic etiology of Alzheimer's disease and related dementias.

Nat Genet 2022 Apr 4;54(4):412-436. Epub 2022 Apr 4.

Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Read More

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Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle.

Nat Commun 2022 04 1;13(1):1748. Epub 2022 Apr 1.

School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.

The endoplasmic reticulum (ER) regulates cellular protein and lipid biosynthesis. ER dysfunction leads to protein misfolding and the unfolded protein response (UPR), which limits protein synthesis to prevent cytotoxicity. Chronic ER stress in skeletal muscle is a unifying mechanism linking lipotoxicity to metabolic disease. Read More

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Investigating the association between inpatient stroke therapy and disability, destination on discharge, length of stay and mortality: a prospective cohort study using the Sentinel Stroke National Audit Programme.

BMJ Open 2022 Apr 1;12(4):e059684. Epub 2022 Apr 1.

Stroke & Vascular Research Centre, School of Nursing, Midwifery & Social Work, The University of Manchester, Manchester, UK.

Objective: 'More is better' is a recognised mantra within stroke therapy, however, this has been developed in patients receiving long term rehabilitation. We investigated the relationship between amount of therapy received (from therapists and psychologists) and key patient outcomes during inpatient care.

Design: A secondary analysis of data from a prospective cohort study was performed. Read More

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eLearning significantly improves maternity professionals' knowledge of the congenital cytomegalovirus prevention guidelines.

Aust N Z J Obstet Gynaecol 2022 Mar 29. Epub 2022 Mar 29.

Royal Hospital for Women, Randwick, Western Australia, Australia.

Aims: Cytomegalovirus (CMV) is a preventable cause of neurodevelopmental disability. Australian guidelines recommend that pregnant women are informed about CMV to reduce their risk of infection; however, less than 10% of maternity health professionals routinely provide prevention advice. The aim was to develop and evaluate the effectiveness of an eLearning course for midwives to improve knowledge and confidence about CMV. Read More

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