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    1 OF 87

    Multi-state Syphilis Outbreak among American Indians, 2013-2015.
    Sex Transm Dis 2018 Feb 13. Epub 2018 Feb 13.
    Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
    This article summarizes a multi-state outbreak of heterosexual syphilis, including 134 cases of syphilis in adults and adolescents and at least two cases of congenital syphilis, which occurred on an American Indian reservation in the United States during 2013-2015. In addition to providing salient details about the outbreak, the article seeks to document the case-finding and treatment activities undertaken, their relative success or failure, and the lessons learned from a coordinated, multiagency response. Of 134 adult cases of syphilis, 40% were identified by enhanced, interagency contact tracing and partner services; 26% through symptomatic testing; and 16% through screening of asymptomatic individuals as the result of an electronic medical record (EMR) screening prompt. Read More

    Cryosurgery + 5% 5-Fluorouracil for Treatment of Superficial Basal Cell Carcinoma and Bowen's Disease.
    J Cutan Med Surg 2018 Feb 1:1203475418758973. Epub 2018 Feb 1.
    2 Department of Medicine, Division of Dermatology, University of Alberta, Edmonton, AB, Canada.
    Background: Superficial basal cell carcinoma (sBCC) and squamous cell carcinoma in situ (SCCis) are 2 types of nonmelanoma skin cancers (NMSCs) that are amenable to treatment with topical 5-fluorouracil, cryosurgery, or topical imiquimod, among other destructive and surgical modalities. There are few studies examining the effectiveness of combination therapy with 5% 5-fluorouracil and cryosurgery for the treatment of sBCC and SCCis.

    Objectives: Our objective was to study the clinical cure rate achieved with the regimen of cryosurgery and a 3-week course of 5% 5-fluorouracil in the treatment of biopsy-proven sBCC and SCCis. Read More

    Photodiagnosis Photodyn Ther 2018 Feb 15. Epub 2018 Feb 15.
    Department of Dermatology, Hospital Central de la Cruz Roja, Madrid, Spain.
    Background: Photodynamic therapy (PDT) is a good option for the treatment of Bowen's disease (BD) but, BD occasionally develops into a squamous cell carcinoma (SCC) after PDT.

    Objective: Find predictors of aggressiveness of BD after PDT METHODS: Two biopsies of patients with BD treated with PDT with progression to SCC within three months were selected for immunohistochemical (IHC) studies. Conventional PDT was applied. Read More

    West Nile and St. Louis encephalitis viral genetic determinants of avian host competence.
    PLoS Negl Trop Dis 2018 Feb 15;12(2):e0006302. Epub 2018 Feb 15.
    Division of Vector-Borne Diseases, Arboviral Disease Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America.
    West Nile virus (WNV) and St. Louis encephalitis (SLEV) virus are enzootically maintained in North America in cycles involving the same mosquito vectors and similar avian hosts. However, these viruses exhibit dissimilar viremia and virulence phenotypes in birds: WNV is associated with high magnitude viremias that can result in mortality in certain species such as American crows (AMCRs, Corvus brachyrhynchos) whereas SLEV infection yields lower viremias that have not been associated with avian mortality. Read More

    The role of reflectance confocal microscopy in a case of Bowen's disease difficult to diagnose.
    Dermatol Pract Concept 2018 Jan 31;8(1):63-65. Epub 2018 Jan 31.
    Department of Dermatology, Faculty of Medicine, University of Ege, Izmir, Turkey.
    There have been limited reports describing reflectance confocal microscopy (RCM) features of Bowen's disease (BD). Herein, we describe the RCM features of a pigmented BD with atypical dermoscopic features, mimicking a melanoma. This case highlights the importance of RCM in a challenging BD. Read More

    Iron-Insensitive Quantitative Assessment of Subcortical Gray Matter Demyelination in Multiple Sclerosis Using the Macromolecular Proton Fraction.
    AJNR Am J Neuroradiol 2018 Feb 8. Epub 2018 Feb 8.
    Multiple Sclerosis Center (P.R., A.M., P.Q., L.K.J.H., B.G., J.D.B.), Swedish Neuroscience Institute, Seattle, Washington.
    Background And Purpose: Fast macromolecular proton fraction mapping is a recent quantitative MR imaging method for myelin assessment. The objectives of this study were to evaluate the macromolecular proton fraction as a measure of demyelination in subcortical GM structures in multiple sclerosis and assess a potential relationship between demyelination and excess iron deposition using the macromolecular proton fraction and T2* mapping.

    Materials And Methods: Macromolecular proton fraction and T2* maps were obtained from 12 healthy controls, 18 patients with relapsing-remitting MS, and 12 patients with secondary-progressive MS using 3T MR imaging. Read More

    The Integrated Genomic Landscape of Thymic Epithelial Tumors.
    Cancer Cell 2018 Feb;33(2):244-258.e10
    Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA. Electronic address:
    Thymic epithelial tumors (TETs) are one of the rarest adult malignancies. Among TETs, thymoma is the most predominant, characterized by a unique association with autoimmune diseases, followed by thymic carcinoma, which is less common but more clinically aggressive. Using multi-platform omics analyses on 117 TETs, we define four subtypes of these tumors defined by genomic hallmarks and an association with survival and World Health Organization histological subtype. Read More

    Quantum Language of MicroRNA: Application for New Cancer Therapeutic Targets.
    Methods Mol Biol 2018 ;1733:145-157
    Retroviral Genetics Group, Pharmaco-MicroRNA Genomics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan.
    MicroRNA (miRNA) is the noncoding gene: therefore, the miRNA gene inheritably controls protein gene expression through transcriptional and post-transcriptional levels. Aberrant expression of miRNA genes causes various human diseases, especially cancers. Although cancer is a complex disease, cancer/miRNA implication has yet been grasped from the perspective of miRNA profile in bed side. Read More

    Toward consensus reporting of radiation-induced liver toxicity in the treatment of primary liver malignancies: Defining clinically relevant endpoints.
    Pract Radiat Oncol 2017 Nov 4. Epub 2017 Nov 4.
    Department of Radiation Oncology, University of Washington, Seattle, Washington. Electronic address:
    Background: Our purpose was to define the most clinically relevant "nonclassic" radiation-induced liver disease (RILD) endpoints in cirrhotic patients receiving stereotactic body radiation therapy or proton beam therapy for primary liver cancer.

    Methods And Materials: We retrospectively collected pretreatment, detailed toxicity (≤6 months posttreatment), and outcomes data from 48 patients. Deaths were examined for association with RILD. Read More

    Association between empirically derived dietary patterns with blood lipids, fasting blood glucose and blood pressure in adults - the India migration study.
    Nutr J 2018 Feb 8;17(1):15. Epub 2018 Feb 8.
    London School of Hygiene and Tropical Medicine, London, UK.
    Background: Dietary patterns (DPs) in India are heterogenous. To date, data on association of indigenous DPs in India with risk factors of nutrition-related noncommunicable diseases (cardiovascular disease and diabetes), leading causes of premature death and disability, are limited. We aimed to evaluate the associations of empirically-derived DPs with blood lipids, fasting glucose and blood pressure levels in an adult Indian population recruited across four geographical regions of India. Read More

    A synthesis of the world's guidelines on photodynamic therapy for non-melanoma skin cancer.
    G Ital Dermatol Venereol 2018 Feb 7. Epub 2018 Feb 7.
    Department of Dermatology, Stirling Community Hospital, Stirling, UK -
    Photodynamic therapy (PDT), using topically administered photosensitizing agents, is widely approved as a treatment for certain nonmelanoma skin cancers. As a tissue-sparing non-surgical modality, there is great potential for PDT to enhance the choice of therapies available to treat, and potentially prevent, skin cancer. Treatment-specific guidelines have assessed the evidence for various photosensitizing agents and light sources, dosimetry, and evaluate reported adverse effects. Read More

    Disparities in severe shigellosis among adults - Foodborne diseases active surveillance network, 2002-2014.
    BMC Public Health 2018 02 7;18(1):221. Epub 2018 Feb 7.
    Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30333, USA.
    Background: Shigella causes approximately 500,000 illnesses, 6000 hospitalizations, and 40 deaths in the United States annually, but incidence and populations at risk for severe shigellosis among adults are unclear. This study describes severe shigellosis among US adults.

    Methods: We analyzed Foodborne Diseases Active Surveillance Network data for infections caused by Shigella among adults ≥18 years old during 2002-2014. Read More

    Photodynamic Therapy Activated by Intense Pulsed Light in the Treatment of Nonmelanoma Skin Cancer.
    Biomedicines 2018 Feb 7;6(1). Epub 2018 Feb 7.
    Skin Center, Dermo-Aesthetic Lasers Centers, 67051 Avezzano, Italy.
    Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) has proven to be a highly effective conservative method for the treatment of actinic keratosis (AK), Bowen's disease (BD), and superficial basal cell carcinoma (sBCC). PDT is traditionally performed in association with broad-spectrum continuous-wave light sources, such as red or blue light. Recently, intense pulsed light (IPL) devices have been investigated as an alternative light source for PDT in the treatment of nonmelanoma skin cancers (NMSC). Read More

    Raising the stakes: Loss of efflux-pump regulation decreases meropenem susceptibility in Burkholderia pseudomallei.
    Clin Infect Dis 2018 Jan 31. Epub 2018 Jan 31.
    Global and Tropical Health Division, Menzies School of Health Research, Tiwi, Northern Territory, Australia.
    Background: Burkholderia pseudomallei, the causative agent of the high-mortality disease melioidosis, is a Gram-negative bacterium that is naturally resistant to many antibiotics. There is no vaccine for melioidosis, and effective eradication is reliant on biphasic and prolonged antibiotic administration. The carbapenem drug, meropenem, is the current gold-standard option for treating severe melioidosis. Read More

    The NICE-GUT trial protocol: a randomised, placebo controlled trial of oral nitazoxanide for the empiric treatment of acute gastroenteritis among Australian Aboriginal children.
    BMJ Open 2018 02 1;8(2):e019632. Epub 2018 Feb 1.
    Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Subiaco, Australia.
    Introduction: Diarrhoeal disease is the second leading cause of death in children under 5 years globally, killing 525 000 annually. Australian Aboriginal and Torres Strait Islander (hereafter Aboriginal) children suffer a high burden of disease. Randomised trials in other populations suggest nitazoxanide accelerates recovery for children with, amoebiasis,gastroenteritis, as well as in cases where no enteropathogens are found. Read More

    Zoonotic pathogens from feral swine that pose a significant threat to public health.
    Transbound Emerg Dis 2018 Jan 31. Epub 2018 Jan 31.
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
    The natural fecundity of suids, great ability to adapt to new habitats and desire for local hunting opportunities leading to translocation of feral pigs to regions where they are not yet established have all been instrumental in the home range expansion of feral swine. Feral swine populations in the United States continue to expand, wreaking havoc on agricultural lands, further compromising threatened and endangered species, and posing a microbiological threat to humans, domestic livestock and companion animals. This manuscript thoroughly reviews zoonotic diseases of concern including brucellosis, bovine tuberculosis, leptospirosis, enteric pathogens, both Salmonella spp. Read More

    Clinical experience of ingenol mebutate gel for the treatment of Bowen's disease.
    J Dermatol 2018 Jan 31. Epub 2018 Jan 31.
    Department of Dermatology, Korea University College of Medicine, Seoul, Korea.
    There are only a few anecdotal case reports about Bowen's disease (BD) treated with ingenol mebutate (IM) gel but no clinical study has been published yet. The aim of this study was to evaluate the effectiveness of IM gel in the treatment of BD and to observe the therapeutic efficacy of IM alone or IM with ablative fractional laser pretreatment. Nineteen patients with BD or squamous cell carcinoma in situ confirmed by skin biopsy were enrolled. Read More

    Nutrition and Cardiovascular Disease-an Update.
    Curr Atheroscler Rep 2018 Jan 30;20(2). Epub 2018 Jan 30.
    Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA, 16802, USA.
    Purpose Of Review: This review summarizes recent developments in nutrition and cardiovascular disease (CVD) prevention.

    Recent Findings: Contemporary dietary guidance recommends healthy dietary patterns with emphasis on food-based recommendations because the totality of the diet (i.e. Read More

    Right ventricular involution: What can we learn from nature's model of compensated hypertrophy?
    J Thorac Cardiovasc Surg 2017 Dec 19. Epub 2017 Dec 19.
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah. Electronic address:
    Background: Right ventricular (RV) failure (RVF) is a vexing problem facing patients with various disease processes and carries a high mortality. RVF is a poorly understood phenomenon with limited treatment options. In mammalian fetal circulation, the right ventricle is the systemic ventricle. Read More

    Implementing Key Drivers for Diabetes Self-Management Education and Support Programs: Early Outcomes, Activities, Facilitators, and Barriers.
    Prev Chronic Dis 2018 Jan 25;15:E15. Epub 2018 Jan 25.
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.

    Pulsed-dye laser therapy for carcinoma in situ of the penis.
    Br J Dermatol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
    Carcinoma in situ (CIS) of the penis is a precancerous condition with a 5 to 10% risk for progression into an invasive penile squamous cell carcinoma (SCC). Clinical variants of genital CIS encompass bowenoid papulosis, erythroplasia of Queyrat and Bowen's disease. Treatment options of penile CIS include topical application of 5-fluorouracil (5-FU) or imiquimod, photodynamic therapy (PDT), ablative laser therapy, cryotherapy and surgery. Read More

    Surveillance for Tick-Borne Viruses Near the Location of a Fatal Human Case of Bourbon Virus (Family Orthomyxoviridae: Genus Thogotovirus) in Eastern Kansas, 2015.
    J Med Entomol 2018 Jan 20. Epub 2018 Jan 20.
    College of Veterinary Medicine, Kansas State University, Manhattan, KS.
    Bourbon virus (Family Orthomyxoviridae: Genus Thogotovirus) was first isolated from a human case-patient residing in Bourbon County, Kansas, who subsequently died. Before becoming ill in late spring of 2014, the patient reported several tick bites. In response, we initiated tick surveillance in Bourbon County and adjacent southern Linn County during spring and summer of 2015. Read More

    Development of a Multiplexed Microsphere PCR for Culture-Free Detection and Gram-Typing of Bacteria in Human Blood Samples.
    ACS Infect Dis 2018 Jan 31. Epub 2018 Jan 31.
    Division of Immunology, QIMR Berghofer Medical Research Institute , 300 Herston Road, Brisbane, Queensland 4006, Australia.
    Bloodstream infection is a significant clinical problem, particularly in vulnerable patient groups such as those undergoing chemotherapy and bone marrow transplantation. Clinical diagnostics for suspected bloodstream infection remain centered around blood culture (highly variable timing, in the order of hours to days to become positive), and empiric use of broad-spectrum antibiotics is therefore employed for patients presenting with febrile neutropenia. Gram-typing provides the first opportunity to target therapy (e. Read More

    Yersinia pestis Survival and Replication in Potential Ameba Reservoir.
    Emerg Infect Dis 2018 Feb;24(2):294-302
    Plague ecology is characterized by sporadic epizootics, then periods of dormancy. Building evidence suggests environmentally ubiquitous amebae act as feral macrophages and hosts to many intracellular pathogens. We conducted environmental genetic surveys and laboratory co-culture infection experiments to assess whether plague bacteria were resistant to digestion by 5 environmental ameba species. Read More

    A Comparison of the Local Flap and Skin Graft by Location of Face in Reconstruction after Resection of Facial Skin Cancer.
    Arch Craniofac Surg 2017 Dec 23;18(4):255-260. Epub 2017 Dec 23.
    Department of Plastic and Reconstructive Surgery, Institute of Health Sciences, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
    Background: Surgery for reconstruction of defects after surgery should be performed selectively and the many points must be considered. The authors conducted this study to compare the local flap and skin graft by facial location in the reconstruction after resection of facial skin cancer.

    Methods: The authors performed the study in patients that had received treatment in Department of Plastic Surgery, Gyeongsang National University. Read More

    A double-blind, placebo-controlled, single ascending-dose study of remyelinating antibody rHIgM22 in people with multiple sclerosis.
    Mult Scler J Exp Transl Clin 2017 Oct-Dec;3(4):2055217317743097. Epub 2017 Nov 21.
    Acorda Therapeutics Inc, Ardsley, NY, USA.
    Objective: The objective of this paper is to assess, in individuals with clinically stable multiple sclerosis (MS), the safety, tolerability, pharmacokinetics (PK) and exploratory pharmacodynamics of the monoclonal recombinant human antibody IgM22 (rHIgM22).

    Methods: Seventy-two adults with stable MS were enrolled in a double-blind, randomized, placebo-controlled, single ascending-dose, Phase 1 trial examining rHIgM22 from 0.025 to 2. Read More

    The Most Common Causes of Eye Pain at 2 Tertiary Ophthalmology and Neurology Clinics.
    J Neuroophthalmol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Ophthalmology and Visual Sciences (RCB, CC, KBS, BJK, JEAW, AVC, KBD), John A Moran Eye Center, Salt Lake City, Utah; Department of Neurology (RCB, CC, KBS, BJK, JEAW, AVC, KBD), University of Utah Health Sciences Center, Salt Lake City, Utah; Departments of Ophthalmology and Neurology (JK, KL, DS), University Hospital Zurich, University of Zurich, Zurich, Switzerland; Department of Ophthalmology and Neurosurgery (HK), University of California at Los Angeles, Los Angeles, California; and Department of Pharmacotherapy (JM), College of Pharmacy, University of Utah, Salt Lake City, Utah.
    Background: Eye pain is a common complaint, but no previous studies have determined the most common causes of this presenting symptom. Our objective was to determine the most common causes of eye pain in 2 ophthalmology and neurology departments at academic medical centers.

    Methods: This was a retrospective cross-sectional analysis and chart review at the departments of ophthalmology and neurology at the University Hospital Zurich (USZ), University of Zürich, Switzerland, and the University of Utah (UU), USA. Read More

    The international WAO/EAACI guideline for the management of hereditary angioedema - the 2017 revision and update.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Department of Medicine and Pediatrics, Penn State University, Hershey, PA, USA.
    Hereditary angioedema (HAE) is a rare disease and a serious health problem, globally and for affected patients and their families. The pathophysiological background is primarily a vascular reaction to an overshooting local production of bradykinin. Evidence-based recommendations are needed to inform and guide clinical decision makers. Read More

    Fight Fungi with Fungi: Antifungal Properties of the Amphibian Mycobiome.
    Front Microbiol 2017 14;8:2494. Epub 2017 Dec 14.
    Department of Biology, University of Massachusetts Boston, Boston, MA, United States.
    Emerging infectious diseases caused by fungal taxa are increasing and are placing a substantial burden on economies and ecosystems worldwide. Of the emerging fungal diseases, chytridomycosis caused by the fungus(hereafter) is linked to global amphibian declines. Amphibians have innate immunity, as well as additional resistance through cutaneous microbial communities. Read More

    5-fluorouracil chemowraps for the treatment of multiple actinic keratoses.
    Eur J Dermatol 2017 Dec;27(6):635-640
    Department of Dermatology, Nantes University Hospital; INSERM U1232, CIC Biothérapie, Nantes, France.
    Few satisfactory treatment options are available for widespread areas affected by multiple actinic keratoses (AKs). Our primary objective was to assess the response rate to weekly 5-fluorouracil (5-FU) chemowraps on widespread AK lesions, and secondarily to assess tolerability, the percentage of patients with recurrence and time to recurrence, the response rate for patients with associated Bowen's disease (BD), and the percentage of squamous cell carcinomas (SCCs) identified after treatment. We conducted an open study which included all the patients who had been treated with weekly 5-FU chemowraps in our department over the course of five years for areas of widespread AKs. Read More

    A 15-Year Old Burmese Girl With Hemoptysis: A Case Report.
    Open Forum Infect Dis 2017 23;4(4):ofx224. Epub 2017 Oct 23.
    Department of Microbiology, Pathwest QEII Laboratory, Perth, Australia.
    We report the case of a 15-year-old Burmese girl who presented with hemoptysis 3 years after immigrating to Australia with a background of previously treated pulmonary tuberculosis at 6 years of age. Cavitation in the right upper lobe had originally been identified on her baseline chest radiograph following arrival to Australia; extensive investigations were conducted thereafter to exclude causes of cavitary lung disease; these were negative.was finally diagnosed on serological grounds 3 years after this child's original presentation, with subsequent identification ofin sputum and in stool. Read More

    Subsequent non-melanoma skin cancers and impact of immunosuppression in liver transplant recipients.
    J Am Acad Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Hospices Civils de Lyon, Edouard Herriot Hospital, Department of Digestive Diseases, Lyon, France; Université Claude Bernard Lyon 1, Lyon, France. Electronic address:
    Background: Non-melanoma skin cancers (NMSC) are the most frequent cancers in solid organ transplant recipients, with a high rate of subsequent tumors.

    Objectives: To describe subsequent NMSC in a large cohort of liver transplant recipients (LTR) with long follow-up, and to analyze the factors influencing it, including immunosuppressive regimen.

    Methods: Ninety-eight LTR (76 male) with a personal post-transplant history of squamous-cell carcinoma (SCC), basal-cell carcinoma (BCC) or Bowen's disease were included, with a median follow-up of 12. Read More

    Emergence of G12 and G9 rotavirus genotypes in the Central African Republic, January 2014 to February 2016.
    BMC Res Notes 2018 Jan 5;11(1). Epub 2018 Jan 5.
    Institut Pasteur, Bangui, Central African Republic.
    Objectives: Rotavirus gastroenteritis is a major cause of death among children under 5 years globally. A rotavirus gastroenteritis surveillance program started in October 2011 in the Central African Republic (CAR) with the Surveillance Epidémiologique en Afrique Centrale (SURVAC) project. We present here genotyping results showing the emergence of G9 and G12 genotypes in Central African Republic. Read More

    Body Mass Index Affects Proximal Femoral but Not Acetabular Morphology in Adolescents Without Hip Pathology.
    J Bone Joint Surg Am 2018 Jan;100(1):66-74
    Departments of Orthopedic Surgery (E.N.N., P.E.M., G.B., and Y.-J.K.) and Radiology (S.D.B.), Boston Children's Hospital, Boston, Massachusetts.
    Background: Increased mechanical load secondary to a large body mass index (BMI) may influence bone remodeling. The purpose of this study was to investigate whether BMI is associated with the morphology of the proximal part of the femur and the acetabulum in a cohort of adolescents without a history of hip disorders.

    Methods: We evaluated pelvic computed tomographic (CT) images in 128 adolescents with abdominal pain without a history of hip pathology. Read More

    Vertical transmission of hepatitis C: Testing and health-care engagement.
    J Paediatr Child Health 2018 Jan 2. Epub 2018 Jan 2.
    Drug Health Services, Sydney Local Health District, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
    Aim: To investigate hepatitis C virus (HCV) testing patterns and engagement with health care for women positive for HCV antibodies (anti-HCV) in pregnancy and their children through pregnancy and the first 2 years of the child's life.

    Methods: At a large inner-city Australian hospital from 2010 to 2012, anti-HCV positive pregnant women were recruited into a cohort study from pregnancy to 2 years post-delivery. Maternal and child data were collected by questionnaire and medical record extraction. Read More

    Spectrum of Aortic Disease in the Giant Cell Arteritis Population.
    Am J Cardiol 2018 Feb 23;121(4):501-508. Epub 2017 Nov 23.
    Mayo Clinic Rochester, Division of Cardiovascular Disease, Rochester, Minnesota. Electronic address:
    We report the spectrum of aortic involvement in patients with giant cell arteritis (GCA) following review of medical records of 4,006 patients including those with imaging studies. A total of 1,450 patients (36%) had a confirmed diagnosis of GCA. Of these, 974 had aortic imaging. Read More

    Correlation of telomere length to malignancy potential in non-melanoma skin cancers.
    Oncol Lett 2018 Jan 26;15(1):393-399. Epub 2017 Oct 26.
    Department of Dermatology, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
    Telomeres are associated with cell fate and aging through their role in the cellular response to stress and growth stimulation resulting from previous cell divisions and DNA damage. Telomere shortening has been observed in most human cancers, and is known to be a feature of malignancy. The aim of this study is to clarify whether telomere length is related to the malignant potential of non-melanoma skin cancers. Read More

    Re-emerging and newly recognized sexually transmitted infections: Can prior experiences shed light on future identification and control?
    PLoS Med 2017 Dec 27;14(12):e1002474. Epub 2017 Dec 27.
    Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
    How do we spot the next sexually transmitted infection? Kyle Bernstein and colleagues look for lessons from past discovery. Read More

    Histology of Non-Melanoma Skin Cancers: An Update.
    Biomedicines 2017 Dec 20;5(4). Epub 2017 Dec 20.
    Department of Dermatology, Dipartimento di Medicina Interna e Specialità Mediche, La Sapienza University of Rome, 00161 Rome, Italy.
    Non-melanoma skin cancer (NMSC) is the most frequently diagnosed cancer in humans. Several different non-melanoma skin cancers have been reported in the literature, with several histologic variants that frequently cause important differential diagnoses with other cutaneous tumors basal cell carcinoma (BCC) is the most common malignant skin tumor, with different histologic variants that are associated with a greater or less aggressive behavior and that usually may be confused with other primitive skin tumors. Actinic keratosis, Bowen's disease, keratoacanthoma, and invasive squamous cell carcinoma (SCC) correspond to the other line of NMSC, that may have only local tumoral behavior, easy to treat and with local management (as in the case of actinic keratosis (AK), Bowen's disease, and keratoacanthoma) or a more aggressive behavior with a potential metastatic spread, as in case of invasive SCC. Read More

    Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess.
    Open Forum Infect Dis 2017 2;4(4):ofx232. Epub 2017 Nov 2.
    Menzies School of Health Research, Charles Darwin University, North Territory, Australia.
    Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A(GAS) is involved, is controversial. We conducted a systematic review of clinical trials and observational studies that address the utility of SXT for SSTI treatment, caused by either GAS or, including methicillin-resistant (MRSA). Read More

    Extramammary Paget's disease in an HIV-positive patient.
    Rom J Morphol Embryol 2017 ;58(3):1009-1015
    Department of Pathology, "Colentina" Clinical Hospital, Bucharest, Romania;
    Extramammary Paget's disease (EMPD) is an uncommon intraepithelial carcinoma usually found as an irregular, pruritic plaque on the apocrine-rich anogenital skin. Diagnosis of EMPD is challenging due to the rarity of the disease and the uncharacteristic clinical aspect and requires histopathological confirmation. We report the case of a 62-year-old human immunodeficiency virus (HIV)-positive male, which presents with a lesion of the left part of pubic area with clinical and dermatoscopic appearance suggestive for Bowen's disease but with histopathological diagnosis of EMPD. Read More

    From public health genomics to precision public health: a 20-year journey.
    Genet Med 2017 Dec 14. Epub 2017 Dec 14.
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
    In this paper, we review the evolution of the field of public health genomics in the United States in the past two decades. Public health genomics focuses on effective and responsible translation of genomic science into population health benefits. We discuss the relationship of the field to the core public health functions and essential services, review its evidentiary foundation, and provide examples of current US public health priorities and applications. Read More

    Toward Genetics-Driven Early Intervention in Dilated Cardiomyopathy: Design and Implementation of the DCM Precision Medicine Study.
    Circ Cardiovasc Genet 2017 Dec;10(6)
    From the Division of Human Genetics (D.D.K., A.M., R.E.H.) and Cardiovascular Division (R.E.H.), Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus; and Department of Bioethics & Humanities, University of Washington, Seattle (D.J.B., W.B.).
    Background: The cause of idiopathic dilated cardiomyopathy (DCM) is unknown by definition, but its familial subtype is considered to have a genetic component. We hypothesize that most idiopathic DCM, whether familial or nonfamilial, has a genetic basis, in which case a genetics-driven approach to identifying at-risk family members for clinical screening and early intervention could reduce morbidity and mortality.

    Methods: On the basis of this hypothesis, we have launched the National Heart, Lung, and Blood Institute- and National Human Genome Research Institute-funded DCM Precision Medicine Study, which aims to enroll 1300 individuals (600 non-Hispanic African ancestry, 600 non-Hispanic European ancestry, and 100 Hispanic) who meet rigorous clinical criteria for idiopathic DCM along with 2600 of their relatives. Read More

    Assessing stakeholder perceptions of the acceptability and feasibility of national scale-up for a dual HIV/syphilis rapid diagnostic test in Malawi.
    Sex Transm Infect 2017 Dec;93(S4):S59-S64
    Division of Sexually Transmitted Disease Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
    Objectives: The WHO recommends pregnant women receive both HIV and syphilis testing at their first antenatal care visit, as untreated maternal infections can lead to severe, adverse pregnancy outcomes. One strategy for increasing testing for both HIV and syphilis is the use of point-of-care (rapid) diagnostic tests that are simple, proven effective and inexpensive. In Malawi, pregnant women routinely receive HIV testing, but only 10% are tested for syphilis at their first antenatal care visit. Read More

    Early Results of States' Efforts to Support, Scale, and Sustain the National Diabetes Prevention Program.
    Prev Chronic Dis 2017 Dec 7;14:E130. Epub 2017 Dec 7.
    Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia.
    The Centers for Disease Control and Prevention (CDC) developed a cooperative agreement with health departments in all 50 states and the District of Columbia to strengthen chronic disease prevention and management efforts through the implementation of evidence-based strategies, such as CDC's National Diabetes Prevention Program. The National Diabetes Prevention Program supports organizations to deliver the year-long lifestyle change program that has been proven to prevent or delay the onset of type 2 diabetes among those at high risk. This article describes activities, barriers, and facilitators reported by funded states during the first 3 years (2013-2015) of a 5-year funding cycle. Read More

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