480,271 results match your criteria Bowel Trauma


A multimodal (FACILE) classification for optical diagnosis of inflammatory bowel disease associated neoplasia.

Endoscopy 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology, HSK Hospital, Wiesbaden, Germany.

Background:  Characterization of colonic lesions in inflammatory bowel disease (IBD) remains challenging. We developed an endoscopic classification of visual characteristics to identify colitis-associated neoplasia using multimodal advanced endoscopic imaging (Frankfurt Advanced Chromoendoscopic IBD LEsions [FACILE] classification).

Methods:  The study was conducted in three phases: 1) development - an expert panel defined endoscopic signs and predictors of dysplasia in IBD and, using multivariable logistic regression created the FACILE classification; 2) validation - using 60 IBD lesions from an image library, two assessments of diagnostic accuracy for neoplasia were performed and interobserver agreement between experts using FACILE was determined; 3) reproducibility - the reproducibility of the FACILE classification was tested in gastroenterologists, trainees, and junior doctors after completion of a training module. Read More

View Article
December 2018

Assessment of Bowel Inflammation and Strictures by Magnetic Resonance Enterography in Long-term Crohn´s Disease.

J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Akershus University Hospital, Lørenskog, Norway.

Background: Crohns disease (CD) is a chronic inflammation in the gut that often progresses to fibrosis. Magnetic Resonance Enterography (MRE) is an important diagnostic tool in evaluating CD. We aimed to assess the prevalence of inflammation and stricturing disease in patients with long-term CD and investigate associations with clinical factors. Read More

View Article
December 2018

Redefining the practical utility of blood transcriptome biomarkers in inflammatory bowel diseases.

J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.

Department of Genetics, Maria Sklodowska-Curie Institute - Oncology Centre, Warsaw, Poland.

Background And Aims: The study investigates the practical utility of whole blood gene expression profiling to diagnose inflammatory bowel diseases (IBDs).

Methods: The discovery cohorts included 102 and 51 pediatric IBD patients and controls, and 95 and 46 adult IBD patients and controls, respectively. The replication cohorts included 447 and 76 pediatric IBD patients and controls, and 271 and 108 adult IBD patients and controls, respectively. Read More

View Article
December 2018
1 Read

1,25‑Dihydroxyvitamin D regulates macrophage polarization and ameliorates experimental inflammatory bowel disease by suppressing miR-125b.

Int Immunopharmacol 2018 Dec 9;67:106-118. Epub 2018 Dec 9.

Department of Immunology, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China; Key Laboratory of Tumor Prevention and Treatment of Heilongjiang Province, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China; Institute of Neural Tissue Engineering, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China. Electronic address:

Macrophages are highly plastic cells. Depending on stimulation, macrophages rapidly polarize to functionally distinct phenotypes that are involved in the pathogenesis of inflammatory bowel disease (IBD). 1,25‑Dihydroxyvitamin D (1,25(OH)D) has immunomodulatory activity, and 1,25(OH)D deficiency is correlated with autoimmune diseases, especially IBD. Read More

View Article
December 2018

Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Johns Hopkins University School of Medicine.

Objectives: The gut microbiome is believed to play a role in the susceptibility to and treatment of Clostridium difficile infections (CDIs). It is, however, unknown whether the gut microbiome is also affected by asymptomatic C difficile colonization. Our study aimed to evaluate the fecal microbiome of children based on C difficile colonization, and CDI risk factors, including antibiotic use and comorbid inflammatory bowel disease (IBD). Read More

View Article
December 2018

Social Stress Affects Colonic Inflammation, the Gut Microbiome, and Short Chain Fatty Acid Levels and Receptors.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Center for Microbial Pathogenesis, The Research Institute, Nationwide Children's Hospital, Columbus, OH, United States.

Objectives: Gastrointestinal disorders, such as inflammatory bowel diseases (IBD) and functional gastrointestinal disorders (FGID), involve disrupted homeostatic interactions between the microbiota and the host. Both disorders are worsened during stress, and in laboratory mice, stress exposure has been shown to change the composition of the gut microbiome. Stress-induced changes to the microbiome exacerbate intestinal inflammation and alter intestinal motility in mice. Read More

View Article
December 2018

Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Section of Pediatric Gastroenterology and Nutrition, Texas Children's Hospital, Baylor College of Medicine, Children's Nutrition and Research Center, Houston, TX.

Fecal microbiota transplantation (FMT) is becoming part of the treatment algorithms against recurrent Clostridium difficile infection (rCDI) both in adult and pediatric gastroenterology practice. With our increasing recognition of the critical role the microbiome plays in human health and disease, FMT is also being considered as a potential therapy for other disorders, including inflammatory bowel disease (Crohn disease, ulcerative colitis), graft versus host disease, neuropsychiatric diseases, and metabolic syndrome. Controlled trials with FMT for rCDI have not been performed in children, and numerous clinical and regulatory considerations have to be considered when using this untraditional therapy. Read More

View Article
December 2018

[Operative treatment of acute mesenteric ischaemia].

Magy Seb 2018 Dec;71(4):149-154

Általános, Ér- és Plasztikai Sebészeti Osztály, Markusovszky Egyetemi Oktatókórház 9700 Szombathely, Markusovszky Lajos u. 5.

Introduction: The incidence of acute mesenteric ischemia (AMI) appears to be increasing due to aging in the population with increasing prevalence of comorbidities. Despite the wide-scale availability of diagnostic technologies, the timely detection and correct treatment are not ensured. This is due to the fact that the required CT angiography is not immediately performed and that vascular surgical reconstruction can be performed within the short ischemic tolerance window of the bowels amounting 4-6 hours. Read More

View Article
December 2018

THE ONSET OF CLINICAL MANIFESTATIONS IN INFLAMMATORY BOWEL DISEASE PATIENTS.

Arq Gastroenterol 2018 Jul-Sep;55(3):290-295

Universidade do Estado da Bahia, Departamento de Ciências da Vida, Salvador, BA, Brasil.

Background: The diagnosis of inflammatory bowel disease is often delayed because of the lack of an ability to recognize its major clinical manifestations.

Objective: Our study aimed to describe the onset of clinical manifestations in inflammatory bowel disease patients.

Methods: A cross-sectional study. Read More

View Article
October 2017

IMPACT OF SMALL BOWEL CAPSULE ENDOSCOPY IN IRON DEFICIENCY ANEMIA: INFLUENCE OF PATIENT'SAGE ON DIAGNOSTIC YIELD.

Arq Gastroenterol 2018 Jul-Sep;55(3):242-246

Hospital Senhora da Oliveira, Departamento de Gastroenterologia, Guimarães, Portugal.

Background: Iron deficiency anemia remains one of the main indications to perform small bowel capsule endoscopy. Literature suggests that diagnostic yield is influenced by patient's age but with conflicting results regarding age cutoff.

Objective: We aimed to clarify the differences in diagnostic yield and incidence of specific findings according to age. Read More

View Article
February 2018

VITAMIN D DEFICIENCY AMONG INFLAMMATORYBOWEL DISEASE PATIENTS IN ARGENTINA: A CROSS-SECTIONAL STUDY.

Arq Gastroenterol 2018 Jul-Sep;55(3):216-220

Gastroenterology Department, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.

Background: An association has been established between low serum values of vitamin D and inflammatory bowel disease. There is a lack of evidence on whether this association is still observed in regions where sun exposure throughout the year is higher.

Objective: To compare the prevalence of vitamin D deficiency between inflammatory bowel disease patients and healthy controls. Read More

View Article
January 2018

INFLAMMATORY BOWEL DISEASE: IMPACT ON SCORES OF QUALITY OF LIFE, DEPRESSION AND ANXIETY IN PATIENTS ATTENDING A TERTIARY CARE CENTER IN BRAZIL.

Arq Gastroenterol 2018 Jul-Sep;55(3):202-207

Programa de Pós-Graduação: Ciências da Gastroenterologia e Hepatologia, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Background: Inflammatory bowel disease frequently affects patients at working age, compromising their quality of life in several levels: physical, psychological, familial and social. Few studies have evaluated the impact of Inflammatory bowel disease on quality of life, anxiety and depression in Brazilian patients.

Objective: Evaluate quality of life and its correlation with psychological aspects of patients with inflammatory bowel disease through the Inflammatory Bowel Disease Questionnaire and Hospital Anxiety and Depression Scale. Read More

View Article
November 2017

LATE IMPACT OF THE LAPAROSCOPIC TREATMENT OF DEEP INFILTRATING ENDOMETRIOSIS WITH SEGMENTAL COLORECTAL RESECTION.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1406. Epub 2018 Dec 6.

Medical School, University of Southern Santa Catarina, Palhoça.

Background: Deep infiltrating colorectal endometriosis may severely affect the quality of life and fertility of patients. Although segmental resection is a therapeutic option that provides positive outcomes in the management of symptoms, its functional effects are still unproven.

Aim: Assess the late impact of the laparoscopic approach in treating deep infiltrating endometriosis with segmental colorectal resection. Read More

View Article
December 2018

The Inhibitory Role of M2000 (β-D-Mannuronic Acid) on Expression of Toll-like Receptor 2 and 4 in HT29 Cell Line.

Recent Pat Inflamm Allergy Drug Discov 2018 Dec 11. Epub 2018 Dec 11.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran. Iran.

Background/objectives: Anti-inflammatory agents play a crucial role in controlling inflammatory diseases such as Inflammatory Bowel Disease (IBD) but their use is restricted due to their vast side effects. M2000 (β-D-mannuronic Acid) is a new immunomodulatory drug. According to the capacity of M2000 in suppressing some molecules involved in Toll Like Receptors (TLRs) signaling and reducing oxidative stress we hypothesize that, this molecule may have a potential role in decreasing inflammatory responses in IBD. Read More

View Article
December 2018

Detection of Anti-neutrophil Cytoplasmic Antibodies (ANCA) by Indirect Immunofluorescence.

Methods Mol Biol 2019 ;1901:47-62

Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, The Netherlands.

The eventual presence of anti-neutrophil cytoplasmic antibodies (ANCA) can initially be screened with indirect immunofluorescence (IIF). The majority of laboratories that facilitate ANCA testing use commercial kits. Although in-house assays are not encouraged in routine clinical laboratories, knowledge on the methodological aspects of the assay remains of importance. Read More

View Article
January 2019
1 Read

Pancreaticoduodenectomy with Mesocaval Shunt for Locally Advanced Pancreatic Adenocarcinoma.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1484, Houston, TX, USA.

Introduction: Patients with locally advanced pancreatic cancer (LAPC) represent a challenging group to treat, given the involvement of major vascular structures. In selected patients with favorable biology, temporary mesocaval shunt can facilitate the resection and allow for a safer procedure with enhanced exposure to the superior mesenteric vessels.

Methods: We present a video of a pancreaticoduodenectomy (PD) with temporary mesocaval shunt with left internal jugular (LIJ) vein conduit. Read More

View Article
December 2018

Technical variations and feasibility of transanal ileal pouch-anal anastomosis for ulcerative colitis and inflammatory bowel disease unclassified across continents.

Tech Coloproctol 2018 Dec 11. Epub 2018 Dec 11.

Cedars Sinai Medical Center, 8737 Beverly Blvd. Suite 101, Los Angeles, CA, 90048, USA.

Purpose: Initial reports of transanal ileal pouch-anal anastomosis (taIPAA) suggest safety and feasibility compared with transabdominal IPAA. The purpose of this study was to evaluate differences in technique and results of taIPAA in three centers performing taIPAA across two continents.

Methods: Prospective IPAA registries from three institutions in the US and Europe were queried for patients undergoing taIPAA. Read More

View Article
December 2018

What abdominal radiologists should know about extragenital endometriosis-associated neuropathy.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiology, Hospital Sírio-Libanês, Adma Jafet, 91, Bela Vista, São Paulo, SP, 01308-050, Brazil.

Purpose: The aim of this study is to provide an overview of endometriosis-associated neuropathy and to review main anatomical concepts of intrapelvic peripheral nerves.

Methods: In this pictorial essay, we review the anatomy of pelvic nerves and imaging features of endometriosis-associated neuropathy. We also evaluate clinical findings, imaging features, and outcome of seven patients with endometriosis-associated neuropathy. Read More

View Article
December 2018

Successful medical treatment for a Crohn's disease patient with a perforation by a second-generation patency capsule.

Endosc Int Open 2018 Dec 10;6(12):E1436-E1438. Epub 2018 Dec 10.

Division of Gastroenterology and Hematology/Oncology Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.

 Symptomatic capsule retention is a very rare adverse event following patency capsule, and the vast majority of cases are resolved without either surgical or endoscopic intervention. We herein describe a rare case of small bowel perforation after swallowing a patency capsule in a 37-year-old man suspected of having Crohn's disease. Read More

View Article
December 2018

Effect of Quercetin Monoglycosides on Oxidative Stress and Gut Microbiota Diversity in Mice with Dextran Sodium Sulphate-Induced Colitis.

Authors:
Zhu Hong Meiyu Piao

Biomed Res Int 2018 12;2018:8343052. Epub 2018 Nov 12.

Department of Gastroenterology and Hepatology, Tianjin Medical University, General Hospital, Tianjin 300052, China.

The pathogenesis of inflammatory bowel disease (IBD) is linked to an intricate association of environmental, microbial, and host-related factors. This study examined the potential effects of dietary addition of two preparations from onion, one comprising quercetin aglycone alone (Q: 0.15% polyphenols, quercetin aglycone:quercetin monoglycosides, 98:2) and another comprising quercetin aglycone with monoglycosides (Q+MQ: 0. Read More

View Article
November 2018

Impact of an In-House Pediatric Surgery Unit and Human Milk Centered Enteral Nutrition on Necrotizing Enterocolitis.

Biomed Res Int 2018 13;2018:5042707. Epub 2018 Nov 13.

EKO Children's Hospital, Oberhausen, Witten/Herdecke University, Germany.

The importance for mortality and morbidity of an in-house pediatric surgery unit for premature infants with necrotizing enterocolitis (NEC) remains undefined. Data on 389 consecutive very low birth weight infants with a birth weight <1250 g admitted between 2009 and 2014 was retrospectively analyzed in two almost identical neonatal intensive care units. Epidemiological data (n=172 and n=217, respectively) were comparable. Read More

View Article
November 2018

Homozygosity for the SCN10A Polymorphism rs6795970 Is Associated With Hypoalgesic Inflammatory Bowel Disease Phenotype.

Front Med (Lausanne) 2018 27;5:324. Epub 2018 Nov 27.

Division of Gastroenterology & Hepatology, Department of Medicine, Penn State College of Medicine, Hershey, PA, United States.

Hypoalgesic inflammatory bowel disease (IBD), a condition in which patients with active disease do not perceive and/or report abdominal pain, is associated with serious complications and there is a lack of cost-effective, reliable diagnostic methods to identify "at-risk" patients. The voltage-gated sodium channels (VGSC's), Na1.7, Na1. Read More

View Article
November 2018

Radiation recall myelitis following paclitaxel chemotherapy: The first reported case.

J Radiosurg SBRT 2018 ;5(4):331-334

Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.

Introduction: Stereotactic body radiotherapy (SBRT) of the spine has become an increasingly utilized modality in the United States, most commonly for metastatic disease (McClelland et al., 2017). Spinal SBRT in patients with spinal instrumentation has been sparsely examined. Read More

View Article
January 2018

Safety of dual biological therapy in Crohn's disease: a case series of vedolizumab in combination with other biologics.

BMJ Open Gastroenterol 2018 9;5(1):e000243. Epub 2018 Nov 9.

Department of Medicine, Division of Gastroenterology, University of California, San Francisco, San Francisco, California, USA.

Uncertainty exists regarding safety and efficacy of dual biological therapy (DBT) in inflammatory bowel disease. We present four cases of DBT in Crohn's disease. Three patients had refractory disease non-responsive to biological monotherapy or combination therapy with immunomodulators. Read More

View Article
November 2018

School-related experience and performance with inflammatory bowel disease: results from a cross-sectional survey in 675 children and their parents.

BMJ Open Gastroenterol 2018 24;5(1):e000236. Epub 2018 Nov 24.

Division of Epidemiology and Biometry, Medical Faculty, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Objective: We describe school performance and experience in children with inflammatory bowel disease (IBD) across Germany and Austria. Predictors of compromised performance and satisfaction were evaluated to identify subgroups of increased risk.

Design: This cross-sectional analysis was based on a postal survey in children aged 10-15 with Crohn's disease, ulcerative colitis or unclassified IBD and their families. Read More

View Article
November 2018

Origin, Differentiation, and Function of Intestinal Macrophages.

Front Immunol 2018 27;9:2733. Epub 2018 Nov 27.

Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.

Macrophages are increasingly recognized as essential players in the maintenance of intestinal homeostasis and as key sentinels of the intestinal immune system. However, somewhat paradoxically, they are also implicated in chronic pathologies of the gastrointestinal tract, such as inflammatory bowel disease (IBD) and are therefore considered potential targets for novel therapies. In this review, we will discuss recent advances in our understanding of intestinal macrophage heterogeneity, their ontogeny and the potential factors that regulate their origin. Read More

View Article
November 2018

The Development of Patient-Reported Outcome Measures in Inflammatory Bowel Disease.

Gastroenterol Hepatol (N Y) 2018 Nov;14(11):658-661

Professor University of Michigan School of Medicine Ann Arbor, Michigan.

View Article
November 2018

A predictive algorithm to identify genes that discriminate individuals with fibromyalgia syndrome diagnosis from healthy controls.

J Pain Res 2018 21;11:2981-2990. Epub 2018 Nov 21.

Symptoms Biology Unit, National Institute of Nursing Research (NINR), Bethesda, MD, USA.

Objectives: Fibromyalgia syndrome (FMS) is a chronic and often debilitating condition that is characterized by persistent fatigue, pain, bowel abnormalities, and sleep disturbances. Currently, there are no definitive prognostic or diagnostic biomarkers for FMS. This study attempted to utilize a novel predictive algorithm to identify a group of genes whose differential expression discriminated individuals with FMS diagnosis from healthy controls. Read More

View Article
November 2018

Associations between the R139C polymorphism and susceptibility to thiopurine-induced leukopenia in Asians: a meta-analysis.

Onco Targets Ther 2018 23;11:8309-8317. Epub 2018 Nov 23.

Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China,

Background And Aim: Despite several studies being conducted to examine the associations between the R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. This meta-analysis determined the risk of thiopurine-induced leukopenia conferred by the R139C polymorphism.

Materials And Methods: All eligible studies published in English up to May 2018 were identified by searching PubMed, Web of Science, Embase, and the Cochrane Library. Read More

View Article
November 2018

Pelvic Exenteration Put into Therapeutical and Palliative Perspective: It Is Worth to Try.

Indian J Surg Oncol 2018 Dec 20;9(4):552-557. Epub 2018 Jul 20.

22nd Department of Surgery, Attikon Hospital, University of Athens Medical School, 1 Rimini Str, 124 10 Chaidari, Greece.

Pelvic exenteration (PE) is one of the most drastic operations in surgical oncology, associated with severe morbidity and mortality. The objective of our study was to review our experience of PE in terms of surgical characteristics, complications, and overall survival. All patients who had PE surgery between January 1999 and December 2015 were identified. Read More

View Article
December 2018

Outcome of Bowel Resection in Women with Advanced Ovarian Carcinoma.

Indian J Surg Oncol 2018 Dec 20;9(4):511-518. Epub 2018 Jul 20.

1Department of Gynaecologic Oncology, CMC Hospital, Vellore, 632004 India.

To evaluate the mortality and morbidity related to bowel resection in women with advanced ovarian carcinoma. Retrospective case series of 47 women with stage III and IV carcinoma ovary who underwent bowel resection, over the period of 5 years from Jan 2011 to Dec 2015. The risk factors for perioperative morbidity and death were determined by regression analysis. Read More

View Article
December 2018

Transanal Total Mesorectal Excision for Treatment of Carcinoma in the Middle or Lower Third Rectum: the Technical Feasibility of the Procedure, Pathological Results, and Clinical Outcome.

Indian J Surg Oncol 2018 Dec 4;9(4):442-451. Epub 2018 Aug 4.

3Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.

We are trying to illustrate operative, short-term, and pathological outcomes of transanal total mesorectal excision (TaTME) as a surgical procedure for patients who are suffering cancer in the lower or middle rectum. This study included 25 consecutive patients who underwent TaTME for the mid and low cancer rectum. The primary outcome measures included frequency of postoperative (PO) bleeding, leakage, ileus, days to regain bowel function, days for Foley's removal, and erectile function. Read More

View Article
December 2018

Faecal immunochemical tests (FIT) versus colonoscopy for surveillance after screening and polypectomy: a diagnostic accuracy and cost-effectiveness study.

Gut 2018 Dec 11. Epub 2018 Dec 11.

Cancer Screening and Prevention Research Group (CSPRG), Department of Surgery and Cancer, Imperial College London, London, UK.

Objective: The English Bowel Cancer Screening Programme (BCSP) recommends 3 yearly colonoscopy surveillance for patients at intermediate risk of colorectal cancer (CRC) postpolypectomy (those with three to four small adenomas or one ≥10 mm). We investigated whether faecal immunochemical tests (FITs) could reduce surveillance burden on patients and endoscopy services.

Design: Intermediate-risk patients (60-72 years) recommended 3 yearly surveillance were recruited within the BCSP (January 2012-December 2013). Read More

View Article
December 2018

Soluble transferrin receptor and soluble transferrin receptor/log ferritin index in diagnosis of iron deficiency anemia in pediatric inflammatory bowel disease.

Dig Liver Dis 2018 Nov 22. Epub 2018 Nov 22.

Department of Pediatrics and Gastroenterology, Medical University of Lublin, Lublin, Poland.

Background: There is no single reliable marker of iron homeostasis in inflammatory bowel disease.

Aims: To determine diagnostic usefulness of soluble transferrin receptor and soluble transferrin receptor/log ferritin index in iron deficiency anemia in children with inflammatory bowel disease.

Methods: We assessed soluble transferrin receptor in serum and calculated soluble transferrin receptor/log ferritin index in 75 children with inflammatory bowel disease. Read More

View Article
November 2018

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke.

J Neuroinflammation 2018 Dec 11;15(1):339. Epub 2018 Dec 11.

Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, China.

Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx. Read More

View Article
December 2018

Acute mesenteric venous thrombosis in a pregnant woman at 35 weeks of gestation: a case report and review of the literature.

BMC Pregnancy Childbirth 2018 Dec 11;18(1):487. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Background: Mesenteric venous thrombosis (MVT) is an infrequent thrombotic event that can cause devastating intestinal hemorrhagic ischemia. The mortality rate among patients with acute MVT ranges from 20 to 50%. Occurrence of MVT in pregnancy is quite rare. Read More

View Article
December 2018

Immunotherapeutic Effects of β-D Mannuronic Acid on IL-4, GATA3, IL-17 and RORC Gene Expression in the PBMC of Patients with Inflammatory Bowel Diseases.

Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):308-317. Epub 2018 Aug 12.

Department of Immunology, School of Public Health, International Campus, Tehran University of Medical Sciences, Tehran, Iran.

Inflammatory bowel diseases (IBD) are chronic relapsing immune-mediated disorders that result from an aberrant immunological response. IBD comprises of Crohn's disease (CD) and ulcerative colitis (UC). The precise aetiology of IBD has not been fully understood, however, recent studies support the hypothesis that patients with IBD have a dysregulated immune response to endogenous bacteria in the gastrointestinal tract (GIT). Read More

View Article
August 2018
1.013 Impact Factor

Intestinal Microbiome, Small Intestinal Bacterial Overgrowth and Inflammatory Bowel Diseases - What are the Connections?

Curr Health Sci J 2015 Jul-Sep;41(3):197-203. Epub 2015 Jan 29.

Department of Gastroenterology, Hepatology, Digestive Endoscopy, Fundeni Clinical Institute, Bucharest, Romania.

IBD (inflammatory bowel diseases) represent chronic idiopathic inflammatory diseases, prone to relapse in the digestive tract; it is estimated that they result from the interaction of the intestinal microbiome with the intestinal immune system. The inflammatory microbiome exerts multiple beneficial roles. Perhaps the central element to developing IBD is dysbiosis; there is still an incompletely established association between intestinal microbiome changes in patients with IBD and SIBO (small intestinal bacterial overgrowth). Read More

View Article
January 2015

Brain MRI Lesions are Related to Bowel Incontinence in Multiple Sclerosis.

J Neuroimaging 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Background And Purpose: Bowel incontinence in multiple sclerosis might be associated with specific lesion sites. This study intended to determine associations between bowel incontinence and cerebral multiple sclerosis lesions using a voxel-wise lesion symptom mapping analysis.

Methods: We conducted a retrospective study of multiple sclerosis patients with self-reported bowel incontinence and matched controls. Read More

View Article
December 2018
1 Read

Same day versus next day antroduodenal manometry results in children with upper gastrointestinal symptoms: A prospective study.

Neurogastroenterol Motil 2018 Dec 11:e13521. Epub 2018 Dec 11.

Center for Motility and Gastrointestinal Functional Disorders, Division of Gastroenterology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: We evaluated the changes in antroduodenal manometry (ADM) parameters and interpretation when the test is performed the day of catheter placement and the following day.

Methods: Catheter was placed endoscopically under anesthesia and recorded on day 1 and repeated on day 2. Study parameters including antrum and small bowel motility index (MI) during fasting, meal, postprandial, erythromycin (EES), and octreotide (OCT) challenge phases, the presence of the phase III of the migrating motor complex (MMC), visual postprandial response, and study interpretation were compared between both days. Read More

View Article
December 2018
1 Read

Exosomes as a novel cell-free therapeutic approach in gastrointestinal diseases.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cell communication through extracellular vesicles (EVs) has been defined for many years and it is not limited only to neighboring cells, but also distant ones in organisms receive these signals. These vesicles are secreted from the variety of cells and are composed of a distinctive component such as proteins, lipids, and nucleic acids. EVs have different classified subgroups regarding their cell origin, in this context, exosomes are the most appealing particles in cell biology, especially clinical in recent years and are represented as novel therapeutic agents with numerous advantages alongside and/or over cell therapy. Read More

View Article
December 2018
1 Read

Role of Inflammasomes in the Development of Gastrointestinal Diseases.

Exp Suppl 2018 ;108:235-268

Sammons Cancer Center, Baylor Simmons Transplant Institute, Dallas, TX, USA.

Many diseases of the gastrointestinal tract have been attributed to chronic inflammation, and a few have identified the role of inflammasomes in their pathogenesis. Inflammasomes are a group of protein complexes comprising of several intracellular proteins that link the sensing of microbial products and metabolic stress to the proteolytic activation of the proinflammatory cytokines. Recent studies have implicated activation of several families of NOD-like receptors (NLRs) which are major components of inflammasomes in the development and exacerbation of many diseases of human systems. Read More

View Article
January 2018

Efficacy and safety of lanreotide in Korean patients with metastatic, well-differentiated gastroenteropancreatic-neuroendocrine tumors: a retrospective analysis.

Invest New Drugs 2018 Dec 10. Epub 2018 Dec 10.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Lanreotide autogel is a long-acting somatostatin analogue with proven efficacy and safety in patients with well-differentiated (WD) gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) in a prior randomized phase III trial (CLARINET). However, the CLARINET study only enrolled patients with Ki-67 index <10%, and few patients of Asian ethnicity were included. We retrospectively analyzed the efficacy and safety of lanreotide in Korean patients with GEP-NETs in the daily practice setting. Read More

View Article
December 2018
1 Read

A propensity score matched comparison of intracorporeal and extracorporeal techniques for robotic-assisted sigmoidectomy in an enhanced recovery pathway.

J Robot Surg 2018 Dec 10. Epub 2018 Dec 10.

Division of Colon and Rectal Surgery, St. Joseph Mercy Hospital, Ann Arbor, 5325 Elliott Dr., Suite #104, Ann Arbor, MI, 48106, USA.

Intracorporeal options for sigmoid resection have been recently developed but not extensively evaluated. This study was designed to assess outcomes comparing intracorporeal and extracorporeal techniques for robotic-assisted sigmoid resection in an established enhanced recovery pathway. This is a retrospective comparison of intracorporeal and extracorporeal techniques for robotic-assisted sigmoid resection for benign and malignant disease. Read More

View Article
December 2018
1 Read

Impact of Long-Course Neoadjuvant Radiation on Postoperative Low Anterior Resection Syndrome and Quality of Life in Rectal Cancer: Post Hoc Analysis of a Randomized Controlled Trial.

Ann Surg Oncol 2018 Dec 7. Epub 2018 Dec 7.

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Background: Neoadjuvant radiation is recommended for locally advanced rectal cancer, with proven benefit in local control but not in disease-free survival. However, the impact of long-course radiation on postoperative bowel function and quality of life (QOL) remains controversial. This study aimed to investigate the impact of long-course neoadjuvant radiation on bowel function and QOL, and to identify risk factors for severe bowel dysfunction. Read More

View Article
December 2018

Microbiome and Gut Dysbiosis.

Exp Suppl 2018 ;109:459-476

Department of Gastroenterology of Medical School, University of Sao Paulo, São Paulo, Brazil.

The gastrointestinal (GI) tract is the residence of trillions of microorganisms that include bacteria, archaea, fungi and viruses. The collective genomes of whole microbial communities (microbiota) integrate the gut microbiome. Up to 100 genera and 1000 distinct bacterial species were identified in digestive tube niches. Read More

View Article
January 2018

Surgical outcomes of patients treated with ustekinumab vs. vedolizumab in inflammatory bowel disease: a matched case analysis.

Int J Colorectal Dis 2018 Dec 10. Epub 2018 Dec 10.

Department of Colorectal Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.

Aim: The association between preoperative use of monoclonal antibodies in inflammatory bowel disease (IBD) patients and postoperative complications is controversial, especially for the latest approved biologics, ustekinumab and vedolizumab, where data is limited. We hypothesized that ustekinumab-treated patients would have a similar overall postoperative complication rate as vedolizumab-treated patients. The aim of this study was to compare postoperative complications in patients receiving preoperative ustekinumab vs. Read More

View Article
December 2018

IBDoc Canadian User Performance Evaluation.

Inflamm Bowel Dis 2018 Dec 8. Epub 2018 Dec 8.

Department of Gastroenterology, University of British Columbia, Vancouver, Canada.

Background: Fecal calprotectin (FC) is a stool biomarker that has been shown to be sensitive and specific for mucosal inflammation in patients with inflammatory bowel disease (IBD). The test is limited by the requirement for patients to collect and return stool samples. A home-based FC test may improve test adherence. Read More

View Article
December 2018

Local Stem Cell Therapy for Crohn's Perianal Fistulae.

Inflamm Bowel Dis 2018 Dec 11. Epub 2018 Dec 11.

Center for Inflammatory Bowel Disease, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, Ohio, USA.

View Article
December 2018

Acupuncture in Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Gastroenterology, Hepatology & Nutrition, Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.

Scientific research into the effects and mechanisms of acupuncture for gastrointestinal diseases including inflammatory bowel disease has been rapidly growing in the past several decades. In this review, we discuss the history, theory, and methodology of acupuncture and review potentially beneficial mechanisms of action of acupuncture for managing inflammatory bowel disease. Acupuncture has been shown to decrease disease activity and inflammation via increase of vagal activity in inflammatory bowel disease. Read More

View Article
December 2018