948 results match your criteria Boutonneuse Fever


Mediterranean spotted fever and peripheral facial nerve palsy: a rare neurological complication.

Int J Infect Dis 2022 Apr 30;117:15-17. Epub 2022 Jan 30.

Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; IHU-Méditerranée Infection, Marseille, France. Electronic address:

Mediterranean spotted fever (MSF) caused by the bacterium Rickettsia conorii is one of the oldest known tick-borne diseases. It is transmitted by the brown dog tick Rhipicephalus sanguineus and occurs mainly in the Mediterranean area. MSF usually presents with a skin rash, high fever, and characteristic eschar at the site of the tick bite. Read More

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Fatal Case of Mediterranean Spotted Fever Associated with Septic Shock, Iran.

Emerg Infect Dis 2022 02;28(2):485-488

A fatal case of Mediterranean spotted fever associated with septic shock was reported in a 61-year-old man living in a village in southeastern Iran. The patient had a history of tick bite a few days before symptom onset. Phylogenetic analysis confirmed infection by Rickettsia conorii subspecies israelensis. Read More

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February 2022

[Diplopia and fever].

Rev Med Interne 2022 04 14;43(4):265-266. Epub 2022 Jan 14.

Médecine interne et polyvalente post-urgences, CHU de Nîmes, Nîmes, France. Electronic address:

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Clinical case report: Not all rickettsiosis are mediterranean spotted fever.

Enferm Infecc Microbiol Clin (Engl Ed) 2022 01 31;40(1):44-45. Epub 2021 Oct 31.

Servicio de Pediatría, Hospital Universitario de Getafe, Madrid, Spain.

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January 2022

Confirmation of Rickettsia conorii Subspecies indica Infection by Next-Generation Sequencing, Shandong, China.

Emerg Infect Dis 2021 10;27(10):2691-2694

We describe 3 similar cases of rickettsial disease that occurred after tick bites in a mountainous rural area of Shandong Province, China. Next-generation sequencing indicated the etiologic agent of 1 patient was Rickettsia conorii subspecies indica. This agent may be more widely distributed across China than previously thought. Read More

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October 2021

A severe case of Israeli spotted fever with pleural effusion in Italy.

Infection 2022 Feb 9;50(1):269-272. Epub 2021 Sep 9.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127, Palermo, Italy.

Background: The most common Italian rickettsiosis is Mediterranean Spotted Fever (MSF). MSF is commonly associated with a symptom triad consisting of fever, cutaneous rash, and inoculation eschar. The rash is usually maculopapular but, especially in severe presentations, may be petechial. Read More

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February 2022

Concomitant Mediterranean spotted fever and systemic lupus erythematosus: a rare case report.

Pan Afr Med J 2021 19;38:377. Epub 2021 Apr 19.

Department of Internal Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia.

Infections are an important cause of morbidity and mortality in Systemic Lupus Erythematosus (SLE). Mediterranean spotted fever (MSF) is a tick-borne disease caused by Rickettsia conorii. This infection is endemic in Tunisia with summer seasonality. Read More

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[Mediterranean spotted fever in immunosuppressed patients].

Semergen 2021 May-Jun;47(4):e31-e32. Epub 2020 Oct 24.

Medicina Familiar y Comunitaria, Centro de Salud Valencia Alfahuir. Departamento Valencia Clínico Malvarrosa, Valencia, España.

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December 2021

Acute disseminated encephalomyelitis due to Rickettsia conorii infection.

S Afr Med J 2021 Mar 31;111(4):307-308. Epub 2021 Mar 31.

Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated acute inflammatory demyelinating disorder, which typically occurs after viral infections or immunisation. We present a case of a man with acute Rickettsia conorii infection whose diagnosis was delayed. He presented with fever, headache, an eschar and an acute paraplegia. Read More

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Renal Involvement in Mediterranean Spotted Fever: Clinical and Histopathological Data.

Med Princ Pract 2021 29;30(4):369-375. Epub 2021 Mar 29.

Department of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University, Plovdiv, Bulgaria.

Objective: Mediterranean spotted fever (MSF) is a tick-borne rickettsial infection endemic to the Mediterranean coastline countries. As a result of growing tourism, imported cases have been registered in many nonendemic countries and regions. We present clinical laboratory parameters and histopathological data on renal impairment in patients with MSF. Read More

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Recent advances in understanding tick and rickettsiae interactions.

Parasite Immunol 2021 05 15;43(5):e12830. Epub 2021 Apr 15.

Center for Molecular and Cellular Biosciences, School of Biological. Environmental, and Earth Sciences, University of Southern Mississippi, Hattiesburg, MS, USA.

Ticks are haematophagous arthropods with unique molecular mechanisms for digesting host blood meal while acting as vectors for various pathogens of public health significance. The tick's pharmacologically active saliva plays a fundamental role in modulating the host's immune system for several days to weeks, depending on the tick species. The vector tick has also developed sophisticated molecular mechanisms to serve as a competent vector for pathogens, including the spotted fever group (SFG) rickettsiae. Read More

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Mediterranean spotted fever associated with leucocytoclastic vasculitis and acute pancraeatitis.

BMJ Case Rep 2021 Feb 23;14(2). Epub 2021 Feb 23.

Laniado Hospital, Sanz Medical Centre, Netanya, Israel.

A young healthy gardener became febrile with abdominal pain, nausea, vomiting and diarrhoea followed by palpable purpura, mostly on the legs and buttocks with associated arthralgia. Dehydration, azotemia and hyponatraemia resolved with fluid replacement. Tests demonstrated acute pancreatitis, hepatitis, thrombocytopenia, microscopic haematuria and proteinuria. Read More

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February 2021

[Septic shock by Rickettsia conorii].

Med Clin (Barc) 2021 11 6;157(10):498-499. Epub 2021 Jan 6.

Servicio de Medicina Intensiva, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

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November 2021

Mediterranean spotted fever in child and adult patients: investigation from an endemic region in Bulgaria.

Cent Eur J Public Health 2020 Sep;28(3):187-192

Medical University, Plovdiv, Bulgaria.

Objectives: Mediterranean spotted fever (MSF) is a tick-borne endemic disease caused by Rickettsia conorii conorii and transmitted to humans by the brown dog tick Rhipicephalus sanguineus. It is characterized by fever, maculopapular rash and a tick bite skin lesion "tache noire". The disease affects all age groups and usually has mild to moderate course. Read More

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September 2020

[Mediterranean spotted fever or DEBONEL?]

An Pediatr (Engl Ed) 2020 12 18;93(6):429. Epub 2020 Jul 18.

Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Barcelona, España.

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December 2020

Early Findings of Rickettsioses in Morocco.

J Vector Borne Dis 2020 Jul-Sep;57(3):281-283

Department of Internal Medicine, University Hospital of Fez, Fez, Morocco.

Background & Objectives: Rickettsioses are zoonoses transmitted to humans by arthropods. They are due to strict intracellular bacteria belonging to the family Rickettsiaceae. Our purpose is to present the clinical and paraclinical characteristics of 14 new cases diagnosed in Al-Hoceima region, Morocco; indeed, the patients associated a diagnosis of Mediterranean Spotted Fever (MSF). Read More

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December 2021

Survival of Rickettsia conorii in artificially contaminated whole and leukoreduced canine blood units during the storage period.

Parasit Vectors 2020 Apr 21;13(1):118. Epub 2020 Apr 21.

Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, PD, Italy.

Background: The ability of tick-borne agents to survive in stored blood bags is a key factor for their transmissibility by blood transfusion. The aim of this study was to evaluate the survival and potential infectivity of Rickettsia conorii (RC) in artificially contaminated canine whole blood (WB) and in leukoreduced whole blood (LR-WB) during the storage period.

Methods: RC was cultured on L929 cells. Read More

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Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections.

Am J Pathol 2020 02 16;190(2):306-322. Epub 2020 Jan 16.

Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas; Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas; Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas. Electronic address:

Mediterranean spotted fever is a reemerging acute tick-borne infection produced by the α-proteobacterium, Rickettsia conorii. Rickettsia conorii infects vascular endothelial cells producing disseminated plasma leakage, manifesting as nonspecific fever, headache, and maculopapular rash. Because there are no available tests of early infection, Mediterranean spotted fever is often undiagnosed and untreated, resulting in significant mortality. Read More

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February 2020

Spatial and temporal trends of Mediterranean spotted fever in Spain, 2005-2015.

Ticks Tick Borne Dis 2020 03 3;11(2):101353. Epub 2019 Dec 3.

Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública CIBERESP), Spain; National Centre for Epidemiology, Instituto de Salud Carlos III, Calle De Melchor Fernández Almagro, 5, 28029, Madrid, Spain.

Background: Mediterranean spotted fever (MSF) is a zoonotic disease caused by Rickettsia conorii and transmitted by Rhipicephalus sanguineus sensu lato. The aim of this study is to understand the epidemiology and trends regarding the disease in Spain, based on notifications to the Spanish National Epidemiology Surveillance Network (RENAVE) and the National Hospital Discharge Database (CMBD) between 2005 and 2015.

Methods: We carried out a retrospective cross-sectional study of the cases and the outbreaks reported to the RENAVE and of those found in the CMBD between January 1, 2005 and December 31, 2015. Read More

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South African Tick Bite Fever: An Overview.

Dermatopathology (Basel) 2019 Apr-Jun;6(2):70-76. Epub 2019 Jun 26.

School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

The rickettsiae are a diverse group of vector-borne zoonotic bacterial pathogens. The two common spotted fever diseases in existence in southern Africa are boutonneuse fever-like tick bite fever (TBF), caused by , and African TBF, caused by . This review addresses demographic, epidemiological, clinical, diagnostic, therapeutic, and preventive aspects of TBF in the southern African context, including a discussion of the dermatopathological findings and potential diagnostic pitfalls. Read More

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[Fever and eruption in 2 neighbors].

Aten Primaria 2020 05 19;52(5):355-356. Epub 2019 Sep 19.

Centro de Salud Calahorra, Calahorra, La Rioja, España.

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Rickettsial infections of the central nervous system.

PLoS Negl Trop Dis 2019 08 29;13(8):e0007469. Epub 2019 Aug 29.

Aix-Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU Mediterranée-Infection, Marseille, France.

As a result of migrations and globalization, people may face a possible increase in the incidence of central nervous system rickettsial infections (CNS R). These diseases, caused by Rickettsia species and transmitted to humans by arthropod bites, are putatively lethal. However, the diagnosis of CNS R is challenging and often delayed due to their nonspecific clinical presentation and the strict intracellular nature of rickettsiae. Read More

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Seroprevalences of Rickettsia conorii, Ehrlichia canis and Coxiella burnetii in Dogs from Montenegro.

Acta Parasitol 2019 Dec 6;64(4):769-778. Epub 2019 Dec 6.

Department of Infectious Animal Diseases and Bee Diseases, Faculty of Veterinary Medicine, University of Belgrade, Belgrade, Serbia.

Purpose: The incidence of vector-borne zoonoses has been increasing in Europe as a result of global climate change, and rickettsioses are a significant etiologic entity among these infections. The objective of this study was to investigate the seroprevalences of Rickettsia conorii, Ehrlichia canis and Coxiella burnetii in dogs in Montenegro.

Methods: The seroepidemiological study covered 259 dogs, of which 155 were owned dogs suspected of infection with agents of rickettsial aetiology from the continental (Podgorica) or five coastal municipalities of Montenegro (Budva, Herceg Novi, Kotor, Ulcinj and Bar), and 104 dogs were from a public shelter in Podgorica. Read More

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December 2019

[Retrospective serological diagnostics of spotted fever group rickettsioses in high risk areas of Rickettsia conorii subsp. Caspia infection.]

Klin Lab Diagn 2019 ;64(6):354-359

N.F. Gamaleya National Research Center for Epidemiology and Microbiology, 123098, Moscow, Russia.

723 blood sera from 537 patients of Regional Infectious Clinical Hospital, Astrakhan were obtained during high activity period of Rhipicephalus ticks (May-September 2015) and retrospectively studied for IgG/IgM to antigen of spotted fever group (SFG) Rickettsia. IgG and/or IgM to Rickettsia conorii were detected in 145 sera from 130 patients, and antibodies to R. sibirica (group-specific) were detected in 143 sera from 145. Read More

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Mediterranean spotted fever in the elderly: a prospective cohort study.

Eur J Clin Microbiol Infect Dis 2019 Jul 11;38(7):1333-1337. Epub 2019 Apr 11.

Infectious Diseases Unit, Internal Medicine Service, Hospital de Terrassa (Consorci Sanitari de Terrassa), Ctra. Torrebonica s/n, 08227, Terrassa, Spain.

The objective of this study is to evaluate the characteristics and outcome of elderly patients with Mediterranean spotted fever (MSF). This study was a prospective observational cohort study of all adult cases with confirmed MSF treated in a teaching hospital (1984-2015) to compare the characteristics of elderly patients (> 65 years) with younger adults. We identified 263 adult patients with MSF, and 53 (20. Read More

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Risk factors for bacterial zoonotic pathogens in acutely febrile patients in Mpumalanga Province, South Africa.

Zoonoses Public Health 2019 08 11;66(5):458-469. Epub 2019 Mar 11.

Division of Public Health Surveillance and Response, Division of the National Health Laboratory Service, National Institute for Communicable Diseases, Johannesburg, South Africa.

Endemic zoonoses, such as Q fever and spotted fever group (SFG) rickettsiosis, are prevalent in South Africa, yet often undiagnosed. In this study, we reviewed the demographics and animal exposure history of patients presenting with acute febrile illness to community health clinics in Mpumalanga Province to identify trends and risk factors associated with exposure to Coxiella burnetii, the causative agent of Q fever, and infection by SFG Rickettsia spp. Clinical and serological data and questionnaires elucidating exposure to animals and their products were obtained from 141 acutely febrile patients between 2012 and 2016. Read More

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Global Transcriptomic Profiling of Pulmonary Gene Expression in an Experimental Murine Model of Infection.

Genes (Basel) 2019 03 8;10(3). Epub 2019 Mar 8.

Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Mediterranean spotted fever develops from an infection with , an obligate intracellular, Gram-negative, endotheliotropic, and tick-transmitted bacterial pathogen, and is an acute, febrile illness that can progress to life-threatening complications if not diagnosed and treated early with effective antibiotics. Despite significant morbidity and mortality, little is known about changes in gene expression that determine the host responses during in vivo infection. We have investigated the transcriptional landscape of host lungs as a prominently affected organ system in an established murine model of infection by RNA-sequencing. Read More

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[Macular atrophy secondary to bilateral involvement in Mediterranean spotted fever].

J Fr Ophtalmol 2019 Feb 22;42(2):e47-e50. Epub 2019 Jan 22.

Service d'ophtalmologie, hôpital Militaire d'Instruction Mohamed V, 10010 Rabat, Maroc.

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February 2019

[Mediterranean spotted fever in a 3-year-old boy treated with doxycycline].

An Pediatr (Engl Ed) 2020 Apr 17;92(4):247-248. Epub 2019 Jan 17.

Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, España.

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