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    1 OF 354

    Dysfunctional Voiders-Medication Versus Urotherapy?
    Curr Urol Rep 2017 Feb;18(2):14
    Department of Urology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 3RCP, Iowa City, IA, 52242-1089, USA.
    Purpose Of Review: Dysfunctional voiding is defined as "habitual contraction of the urethral sphincter during voiding." Children with dysfunctional voiding remain a challenge, and the approach to and management of LUT dysfunction varies widely among programs and providers with the role of pharmacotherapy being ill defined.

    Recent Findings: Animated biofeedback is the current treatment modality of choice in children who are not responsive to standard urotherapy. Read More

    Botulinum toxin treatment for nocturnal calf cramps in patients with lumbar spinal stenosis: A randomized clinical trial.
    Arch Phys Med Rehabil 2017 Feb 13. Epub 2017 Feb 13.
    Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Objectives: To evaluate the clinical effectiveness of botulinum toxin (BTX) injection into the gastrocnemius muscles in lumbar spinal stenosis (LSS) patients with frequent nocturnal calf cramps (NCCs) DESIGN: Prospective randomized clinical trial SETTING: Outpatient department for interventional pain management.

    Participants: Fifty LSS patients with a frequency of NCCs ≥ once per week were enrolled.

    Intervention: Patients were randomly allocated to receive either conservative treatments plus gabapentin (Group GPN) or BTX injection (Group BTX). Read More

    Botulinum toxin type A reduces inflammatory hypernociception induced by arthritis in the temporomadibular joint of rats.
    Toxicon 2017 Feb 13. Epub 2017 Feb 13.
    Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Av Limeira, 901, Piracicaba, São Paulo, 13414-903, Brazil.
    Objective: This study aimed to investigate the antinociceptive effects of Botulinum toxin type A (BoNT-A) on persistent inflammatory hypernociception induced by arthritis in the temporomandibular joint (TMJ) of rats.

    Material And Methods: Wistar rats were induced to persistent inflammatory hypernociception in the left TMJ. Then, animals were treated with intra-TMJ injections of BoNT-A, using doses of 3. Read More

    The Subunit Principle in Scar Face Revision.
    J Craniofac Surg 2017 Feb 15. Epub 2017 Feb 15.
    Department of Plastic Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Facial scaring is considered one of the most difficult cosmetic problems for any plastic surgeon to solve. The condition is more difficult if the direction of the scar is not parallel to relaxed skin tension lines. Attempts to manage this difficult situation included revisions using geometric designs, Z plasties or W plasties to camouflage the straight line visible scaring. Read More

    A data-driven approach for evaluating multi-modal therapy in traumatic brain injury.
    Sci Rep 2017 Feb 16;7:42474. Epub 2017 Feb 16.
    San Francisco Veterans Affairs Medical Center, San Francisco, CA, United States.
    Combination therapies targeting multiple recovery mechanisms have the potential for additive or synergistic effects, but experimental design and analyses of multimodal therapeutic trials are challenging. To address this problem, we developed a data-driven approach to integrate and analyze raw source data from separate pre-clinical studies and evaluated interactions between four treatments following traumatic brain injury. Histologic and behavioral outcomes were measured in 202 rats treated with combinations of an anti-inflammatory agent (minocycline), a neurotrophic agent (LM11A-31), and physical therapy consisting of assisted exercise with or without botulinum toxin-induced limb constraint. Read More

    Anatomical insights of the palmaris brevis muscle for clinical procedures of the hand.
    Clin Anat 2017 Feb 16. Epub 2017 Feb 16.
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Center, Yonsei University College of Dentistry, Seoul, South Korea.
    Introduction: The purpose of the present study is to provide useful data for anatomists and clinicians by describing the topography of the palmaris brevis muscle, taking particular note of its morphology and distribution pattern of the nerve and artery.

    Materials And Methods: Forty-nine hands from adult cadavers were used in this study. Parameters with respect to the size, scale and location of the muscle were measured using a ultrasonography system, digital caliper and surgical microscope. Read More

    A Prospective Multicenter Double-blind Randomized Trial of Bladder Instillation of Liposome Formulation OnabotulinumtoxinA for Interstitial Cystitis/ Bladder Pain Syndrome.
    J Urol 2017 Feb 12. Epub 2017 Feb 12.
    Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan. Electronic address:
    Background: Intravesical instillation of liposomal-formulated botulinum toxin A (lipotoxin) has shown therapeutic effects on treatment of refractory overactive bladder without needle injections. We hereby assessed lipotoxin for the treatment of refractory interstitial cystitis/bladder pain syndrome (IC/BPS).

    Methods: This two-center, double-blind, randomized, placebo-controlled physician-initiated study enrolled patients with refractory IC/BPS. Read More

    The approach and management of bruxism in Alzheimer's disease: An under-recognized habit that concerns caregivers (innovative practice).
    Dementia (London) 2017 Jan 1:1471301217694249. Epub 2017 Jan 1.
    Department of Neurology, St. John's Medical College Hospital, India.
    Bruxism (teeth grinding) is an under-recognized cause of caregiver concern in patients with Alzheimer's disease. We report two cases of Alzheimer's disease with bruxism that caused significant distress to the caregivers. Patient data were collected from the case records of our hospital. Read More

    OnabotulinumtoxinA in urinary incontinence: Prospective Study of a Case Series.
    Actas Urol Esp 2017 Feb 10. Epub 2017 Feb 10.
    Departamento de Obstetricia y Ginecología, Complejo Hospitalario Universitario Insular Materno-Infantil Las Palmas de Gran Canaria, Las Palmas, España.
    Objective: To assess the safety and efficacy of a single intravesical injection of onabotulinumtoxinA (OnaBTA) for treating urge urinary incontinence (UUI) in women.

    Method: We performed a prospective case-series study of consecutive patients with refractory UUI treated with an intravesical injection of OnaBTA. The patients were administered 100 units of OnaBTA injected into the bladder wall following 4 weeks of flushing with anticholinergic agents or beta 3 agonists. Read More

    Treatment Concept for a Patient with a High Smile Line and Gingival Pigmentation: A Case Report.
    Int J Periodontics Restorative Dent 2017 Mar/Apr;37(2):e142-e148
    Today, innovative restorative materials and techniques allow for minimally invasive prosthetic procedures, which are paramount to the preservation of hard and soft dental tissues. An integrated approach combining dental and esthetic medical therapies could be useful to improve the quality of life of patients, improving function, esthetics, and self-confidence. Oral esthetics depends on several variables, including tooth visibility and proportions as well as healthy gingival tissues. Read More

    Management of oral secretions in neurological disease.
    Pract Neurol 2017 Feb 10. Epub 2017 Feb 10.
    Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
    Sialorrhoea is a common and problematic symptom that arises from a range of neurological conditions associated with bulbar or facial muscle dysfunction. Drooling can significantly affect quality of life due to both physical complications such as oral chapping, and psychological complications such as embarrassment and social isolation. Thicker, tenacious oral and pharyngeal secretions may result from the drying management approach to sialorrhoea. Read More

    Ultrastructural changes in human masseter muscles after botulinum neurotoxin a injection.
    Muscle Nerve 2017 Feb 10. Epub 2017 Feb 10.
    Plastic Surgery Hospital of Weifang Medical University, 288 Shenglidongjie Kuiwen Weifang, Shandong, China, 261042.
    Introduction: Botulinum neurotoxin A (BoNTA) has long been used as a therapeutic agent and has been widely accepted as a cosmetic agent in recent years. It can inhibit function and induce structural changes in skeletal muscle.

    Methods: Specimens of fresh dissected human masseter muscle were used to observe the ultrastructural changes that occurred at 6 and 12 months following BoNTA injection. Read More

    Botulinum toxin type A (BTX-A) in the treatment of facial myotonia in Schwartz-Jampel Syndrome.
    Muscle Nerve 2017 Feb 10. Epub 2017 Feb 10.
    Department of Neuroscience and Mental Health, Medical School of Bahia, Federal University of Bahia. Postal address: Praça XV de Novembro, s/n - Largo do Terreiro de Jesus, Salvador, Bahia, Brazil Zip code: 40025-010.

    Improvement of upper trunk posture during walking in hemiplegic patients after injections of botulinum toxin into the arm.
    Clin Biomech (Bristol, Avon) 2017 Jan 26;43:15-22. Epub 2017 Jan 26.
    Department of Neurology, University of Düsseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany.
    Background: It has been hypothesized that altered trunk movements during gait in post-stroke patients or children with cerebral palsy are compensatory to lower limb impairment. Improvement of trunk movements and posture after injections of botulinum toxin into the affected arm would be at variance with this hypothesis and hint towards a multifactorial trunk control deficit.

    Patients And Methods: Clinical gait analysis was performed in 11 consecutively recruited hemiplegic patients immediately before and 4weeks after a botulinum toxin type A-injection into the affected arm. Read More

    An investigation into quality of life improvement in patients undergoing microvascular decompression for hemifacial spasm.
    J Neurosurg 2017 Feb 10:1-9. Epub 2017 Feb 10.
    University of Pittsburgh School of Medicine.
    OBJECTIVE Hemifacial spasm (HFS) is a movement disorder characterized by involuntary spasms of the facial muscles, and it can negatively impact quality of life (QOL). This retrospective study and systematic review with meta-analysis was conducted to investigate the QOL in patients with HFS following intervention with microvascular decompression (MVD) and botulinum toxin (BT). METHODS In the retrospective analysis, a QOL questionnaire was administered to all patients undergoing MVD performed by a single surgeon. Read More

    Botox as an adjunct to lip repositioning for the management of excessive gingival display in the presence of hypermobility of upper lip and vertical maxillary excess.
    Dent Res J (Isfahan) 2016 Nov-Dec;13(6):478-483
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
    Background: Excessive gingival display (GD) is a frequent finding that can occur because of various intraoral or extraoral etiologies. This work describes the use of a mucosal repositioned flap for the management of a gummy smile associated with vertical maxillary excess (VME) and hypermobility of the upper lip followed by injection of Botox.

    Materials And Methods: Seven female patients in the age range of 17-25 years presented with a gummy smile. Read More

    Mechanism of motor coordination of masseter and temporalis muscles for increased masticatory efficiency in mice.
    J Oral Rehabil 2017 Feb 9. Epub 2017 Feb 9.
    Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
    The demand for the use of mice as animal models for elucidating the pathophysiologies and pathogeneses of oral motor disorders has been increasing in recent years, as more and more kinds of genetically modified mice that express functional disorders of the stomatognathic system become available. However, the fundamental characteristics of mouse jaw movements during mastication have yet to be fully elucidated. The purpose of this study was to investigate the roles of the masseter and temporalis muscles, and the mechanisms of motor coordination of these muscles for increasing masticatory efficiency in the closing phase in mice. Read More

    Effect of BTXA on Inhibiting Hypertrophic Scar Formation in a Rabbit Ear Model.
    Aesthetic Plast Surg 2017 Feb 8. Epub 2017 Feb 8.
    Department of Plastic Surgery, The Fourth Affiliated Hospital of Anhui Medical University, 372# Tun-Xi Road, Hefei, 230023, Anhui, China.
    Background: Hypertrophic scar (HS) is a refractory skin disease caused by major physical damage or other inflammation. Some reports found that botulinum toxin type A (BTXA) could be an alternative treatment of the HS. Therefore, the authors studied the effects of BTXA on the treatment of HS and the dose response of BTXA. Read More

    Assessing the immediate impact of botulinum toxin injection on impedance of spastic muscle.
    Med Eng Phys 2017 Feb 3. Epub 2017 Feb 3.
    Department of Physical Medicine and Rehabilitation, University of Texas Medical School at Houston, and TIRR Memorial Hermann Research Center, Houston, TX, USA ; Guangdong Work Injury Rehabilitation Center, Guangzhou, Guangdong Province, China.
    This study aimed to investigate the immediate impacts of Botulinum Toxin A (BoNT-A) injections on the inherent electrical properties of spastic muscles using a newly developed electrical impedance myography (EIM) technique. Impedance measures were performed before and after a BoNT-A injection in biceps brachii muscles of 14 subjects with spasticity. Three major impedance variables, resistance (R), reactance (X) and phase angle (θ) were obtained from three different configurations, and were evaluated using the conventional EIM frequency at 50kHz as well as multiple frequency analysis. Read More

    The WE-Study: does botulinum toxin A make walking easier in children with cerebral palsy?: Study protocol for a randomized controlled trial.
    Trials 2017 Feb 6;18(1):58. Epub 2017 Feb 6.
    Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
    Background: Intramuscular injections of botulinum toxin A (BoNT-A) have been a cornerstone in the treatment of spasticity for the last 20 years. In Norway, the treatment is now offered to two out of three children with spastic cerebral palsy (CP). However, despite its common use, the evidence for its functional effects is limited and inconclusive. Read More

    Botulinum toxin the poison that heals: A brief review.
    Natl J Maxillofac Surg 2016 Jan-Jun;7(1):10-16
    Department of Conservative Dentistry and Endodontics, ESIC Dental College and Hospital, New Delhi, India.
    Botulinum neurotoxins, causative agents of botulism in humans, are produced by Clostridium botulinum, an anaerobic spore-former Gram-positive bacillus. Botulinum neurotoxin poses a major bioweapon threat because of its extreme potency and lethality; its ease of production, transport, and misuse; and the need for prolonged intensive care among affected persons. This paper aims at discussing botulinum neurotoxin, its structure, mechanism of action, pharmacology, its serotypes and the reasons for wide use of type A, the various indications and contraindications of the use of botulinum neurotoxin and finally the precautions taken when botulinum neurotoxin is used as a treatment approach. Read More

    The Efficacy and Safety of OnabotulinumtoxinA or Solifenacin Compared with Placebo in Solifenacin-Naïve Patients with Refractory Overactive Bladder: Results from a Multicenter, Randomized, Double-Blind, Phase 3b Trial.
    J Urol 2017 Feb 1. Epub 2017 Feb 1.
    Ghent University, Ghent, Belgium.
    Purpose: This double-blind, randomized study compared the efficacy/safety of onabotulinumtoxinA or solifenacin versus placebo in overactive bladder patients with urinary incontinence who had an inadequate response to/were intolerant of an anticholinergic. A post-hoc analysis compared effects of onabotulinumtoxinA versus solifenacin.

    Materials And Methods: Solifenacin-naïve patients were randomized to onabotulinumtoxinA 100U, solifenacin 5mg (could escalate to 10mg at week 6 with predefined criteria), or placebo. Read More

    Protocol for a prospective observational study of cortical lower urinary tract control changes following intradetrusor injection of botulinum toxin-A in patients with multiple sclerosis.
    BMJ Open 2017 Feb 3;7(2):e013225. Epub 2017 Feb 3.
    Department of Urology, Methodist Hospital, Houston, Texas, USA.
    Introduction: Multiple sclerosis (MS) is a severe debilitating disease that affects patients' quality of life. Up to 90% of patients with MS will develop lower urinary tract dysfunction within the first 18 years of the disease. If oral pharmacotherapy with anticholinergics, behavioural modifications and pelvic floor physical therapy are unsuccessful, intradetrusor injection of botulinum toxin-A (OnaBotA; Botox Allergan, Dublin, Ireland) is a highly effective option for these patients. Read More

    Botulinum toxin in the management of head and neck disorders.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Dec 7. Epub 2016 Dec 7.
    Department of Oral Medicine and Radiology, New Horizon Dental College and Research Institute, Sakri, Bilaspur, India.
    Botulinum toxin is a polypeptide protoxin synthesized by Clostridium botulinum that results in localized reduction of muscle activity by inhibiting acetylcholine release at the neuromuscular junction. In 2004, the US Food and Drug Administration approved its application in the treatment of various medical conditions, such as facial wrinkles, strabismus, cervical dystonia, blepharospasm, and hyperhidrosis. Later, its application extended to improving dental esthetics and gummy smile. Read More

    Comparison Between Botulinum Toxin A Injection and Lacrimal Punctal Plugs for the Control of Post-LASIK Dry Eye Manifestations: A Prospective Study.
    Ophthalmol Ther 2017 Feb 2. Epub 2017 Feb 2.
    Ophthalmology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Introduction: Laser in situ keratomelieusis (LASIK) is one of the commonest refractive procedures performed nowadays. The dry eye problem is nearly universal in all patients after LASIK and it can be so annoying that the post-operative patient satisfaction is sometimes precluded. Conventional treatment includes the use of artificial tears. Read More

    [What role does botulinum toxin play in the treatment of benign prostatic hyperplasia?]
    Pan Afr Med J 2016 11;24:309. Epub 2016 Aug 11.
    Service d'Urologie A, CHU Ibn Sina, Rabat, Maroc.
    Botulinum toxin (BT) was first used in urology for the treatment of neuro-urological disorders such as bladder sphincter dyssynergia and incontinence due to neuropathic detrusor overactivity. Its action is now clearly demonstrated and it is now widely used in treating neurogenic neuropathic detrusor overactivity. May the botulinic toxin constitute an effective treatment for benign prostatic hyperplasia (BPH)? Intraprostatic BT injection has recently been investigated as a treatment for BPH. Read More

    Treatment of chronic pain associated with nocturnal bruxism with botulinum toxin. A prospective and randomized clinical study.
    J Clin Exp Dent 2017 Jan 1;9(1):e112-e117. Epub 2017 Jan 1.
    Consultant, Dept. of Oral Medicine, Head of preventive dental department, Dental Administration, Riyadh Health, Riyadh, Saudi Arabia.
    Background: To evaluate the role of botulinum toxin type A (BTX-A) in the treatment of pain associated with nocturnal bruxism.

    Material And Methods: Fifty subjects reporting nocturnal bruxism were recruited for a randomized clinical trial. Twenty five bruxers were injected with botulinum toxin in both masseters, and twenty five were treated with traditional methods of treating bruxism. Read More

    Functional Disorders of Constipation: Paradoxical Puborectalis Contraction and Increased Perineal Descent.
    Clin Colon Rectal Surg 2017 Feb;30(1):22-29
    Division of Colon & Rectal Surgery, Department of Surgery, University of South Alabama, Mobile, Alabama.
    Paradoxical puborectalis contraction (PPC) and increased perineal descent (IPD) are subclasses of obstructive defecation. Often these conditions coexist, which can make the evaluation, workup, and treatment difficult. After a thorough history and examination, workup begins with utilization of proven diagnostic modalities such as cinedefecography and anal manometry. Read More

    Positive outcomes with first onabotulinumtoxinA treatment persist long-term with repeat treatments in patients with neurogenic detrusor overactivity.
    BJU Int 2017 Jan 31. Epub 2017 Jan 31.
    Carolinas Rehabilitation, Charlotte, NC, USA.
    Objective: To examine whether response to first treatment with onabotulinumtoxinA is predictive of long-term treatment outcome in neurogenic detrusor overactivity (NDO) patients.

    Patients And Methods: NDO patients in a 3-year extension study (following a 52-week phase 3 study) received onabotulinumtoxinA 'as needed' based on fulfilment of prespecified retreatment criteria. This post-hoc analysis included patients who received only the 200U dose during the phase 3 and extension studies. Read More

    Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study.
    Neuropsychiatr Dis Treat 2017 10;13:127-132. Epub 2017 Jan 10.
    Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Thailand.
    Objective: This study aimed to identify possible improvements in disease-specific health-related quality of life (HRQoL) after multiple injections of botulinum toxin A over 24 weeks in Thai cervical dystonia (CD) patients.

    Materials And Methods: A 24-week prospective study comparing HRQoL of Thai CD patients before and after multiple injections of botulinum toxin A at 3-month intervals was performed. Disease-specific HRQoL was assessed by using the Cervical Dystonia Impact Profile-58 questionnaire (CDIP-58) and the Craniocervical Dystonia Questionnaire-24 (CDQ-24). Read More

    Cellular uptake of Clostridium botulinum C2 toxin requires acid sphingomyelinase activity.
    Infect Immun 2017 Jan 30. Epub 2017 Jan 30.
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro, Tokushima 770-8514, Japan.
    Clostridium botulinum C2 toxin consists of an enzyme component (C2I) and a binding component (C2II). Activated C2II (C2IIa) binds to a cell receptor, giving rise to lipid raft-dependent oligomerization, and then it assembles with C2I. The whole toxin complex is then endocytosed into the cytosol, resulting in destruction of the actin cytoskeleton and cell rounding. Read More

    Median canaliform nail dystrophy treated with a 1064-nm Q-switched Nd:YAG laser.
    J Cosmet Laser Ther 2017 Jan 31. Epub 2017 Jan 31.
    c Kangbuk Samsung Hospital, Sungkkyunkwan University School of Medicine , Dermatology , 108 Pyung-dong Gongro Gu, Seoul , 137-470 Korea(Republic of).
    Median canaliform nail dystrophy is an uncommon and idiopathic dystrophic change, typically appears as central, longitudinal groove or split involving one or both thumbnails. Various treatments including potent topical steroid, an intralesional injection of triamcinolone 2.5 to 3 mg/dL, medications for systemic treatment, and topical psoralen plus ultraviolet A (PUVA) have been tried to treat the disease. Read More

    Efficacy and durability of hyaluronic acid fillers for malar enhancement: a prospective, randomized, spilt-face clinical controlled trial.
    J Cosmet Laser Ther 2017 Jan 31. Epub 2017 Jan 31.
    a Department of Dermatology , College of Medicine, Kyung Hee University , Seoul , Korea.
    Various hyaluronic acid fillers can be used for facial attenuation and rejuvenation. The efficacy and durability of hyaluronic acid fillers are of major concern to dermatologists and patients. This study aimed to evaluate three dimensional morphology, tissue distribution, and changes in volume after injection of two different hyaluronic acid fillers. Read More

    Anatomical relationships of the procerus with the nasal ala and the nasal muscles: transverse part of the nasalis and levator labii superioris alaeque nasi.
    Surg Radiol Anat 2017 Jan 28. Epub 2017 Jan 28.
    Department of Anatomy, Institute for Translational and Clinical Research, Catholic Kwandong University College of Medicine, Room 503, Gangneung, South Korea.
    Purpose: The aim of this study was to clarify the anatomical relationship of the procerus with the nose, especially focusing on the transverse part of the nasalis, the nasal ala, and the levator labii superioris alaeque nasi (LLSAN).

    Materials And Methods: The 53 faces from Korean cadavers were examined anatomically.

    Results: The procerus originated from the superficial and deep layers in all specimens. Read More

    Familial hemifacial spasm of young-onset: Report of two cases.
    J Neurol Sci 2017 Feb 21;373:83-85. Epub 2016 Dec 21.
    Division of Neurology, Department of Neuroscience, Geneva University Hospitals, Geneva, Switzerland. Electronic address:
    Hemifacial spasm (HFS) is defined as an involuntary twitching of the hemifacial muscles supplied by the facial nerve. It is mostly attributed to a vascular compression with the facial nerve. Familial HFS has been described in less than 10% of cases of sporadic HFS and usually develops after the age of 40. Read More

    Combined therapy using botulinum toxin A and single-joint hybrid assistive limb for upper-limb disability due to spastic hemiplegia.
    J Neurol Sci 2017 Feb 28;373:182-187. Epub 2016 Dec 28.
    Department of Neurosurgery, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
    We investigated the combination of robot-assisted rehabilitation (RT) using a single-joint hybrid assistive limb (HAL-SJ) and botulinum toxin A (BTX-A) as therapy for paretic arm with spasticity in post-stroke patients. Participants were seven patients (4 females, 3 males; mean (±SD) age: 60.6±8. Read More

    Preoperative progressive pneumoperitoneum and botulinum toxin type A in patients with large incisional hernia.
    Hernia 2017 Jan 25. Epub 2017 Jan 25.
    Surgical Unit of Abdominall Wall, Department of Digestive Surgery, "La Fe" Universitary Hospital, University of Valencia, Avd. Fernando Abril Martorell 106, 46126, Valencia, Spain.
    Purpose: Combination of preoperative progressive pneumoperitoneum (PPP) and botulinum toxin type A (BT) has not been previously reported in the management of large incisional hernia (LIH).

    Methods: Observational study of 45 consecutive patients with LIH between June 2010 and July 2014. The diameters of the hernia sac, the volumes of the incisional hernia (VIH) and the abdominal cavity (VAC), and the VIH/VAC ratio were measured before and after PPP and BT using abdominal CT scan data. Read More

    Pyloric Therapies for Gastroparesis.
    Curr Treat Options Gastroenterol 2017 Jan 25. Epub 2017 Jan 25.
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, 300 Pasteur Drive Room H0206B, CA, MC 5244, Standford, USA.
    Opinion Statement: Gastroparesis is a syndrome that can be difficult to treat effectively and likely represents the common clinical presentation of multiple underlying mechanisms. One of these presumed mechanisms involves pyloric dysfunction, tied perhaps to spasm or fibrosis, manifesting as functional gastric outlet obstruction. Various diagnostic modalities have been used to better characterize this hypothesized abnormality, including most recently antroduodenal manometry and impedance planimetry. Read More

    Decompression endoscopic surgery for frontal secondary headache attributed to supraorbital and supratrochlear nerve entrapment: a comprehensive review.
    Eur Arch Otorhinolaryngol 2017 Jan 25. Epub 2017 Jan 25.
    Department of Otorhinolaryngology/Head and Neck Surgery, Center for Facial Plastic and Reconstructive Surgery, Diakonessen Hospital, Utrecht, The Netherlands.
    In the last decade, a new surgical treatment modality was developed for frontal secondary headache, based on the assumption that the trigger of this pain entity is the entrapment of peripheral sensory nerves. The surgery entails a procedure, where an endoscopic approach is used to decompress the supraorbital and supratrochlear nerve branches, which are entrapped by the periosteum in the region of the corrugator supercilii muscle. Candidates for the surgery define their headache as moderate to severe persistent daily pressure or tension, localized in the frontal area, sometimes accompanied by symptoms of nausea and photophobia mimicking a primary headache-migraine. Read More

    HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1.
    J Leukoc Biol 2017 Jan 25. Epub 2017 Jan 25.
    Department for Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany; and
    Neutrophil extravasation is a critical step of the innate immune system's response to inflammation. This multistep process is tightly regulated by adhesion and signaling molecules in the endothelium and neutrophils. Activation of the β2 integrin LFA-1 is critical for adhesion of leukocytes to postcapillary venules. Read More

    Botulinum toxin in spinal cord injury patients with neurogenic detrusor overactivity.
    J Exerc Rehabil 2016 Dec 31;12(6):624-631. Epub 2016 Dec 31.
    Department of Urology, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.
    Evidence for the efficacy and safety of intravesical onabotulinum toxin A (onabotA) injections has led to them being licensed in many countries, including Korea, for the treatment of patients with urinary incontinence due to neurogenic detrusor overactivity (NDO) resulting from spinal cord injury or multiple sclerosis who are refractory or intolerant to anticholinergic medications. OnabotA injections have an inhibitory effect on acetylcholine release for up to 10 months, with a recommended dose of 200 U. OnabotA treatment has a beneficial effect not only on urinary symptoms, but also on quality of life. Read More

    Integration of Osteopathic Manual Treatments in Management of Cervical Dystonia with Tremor: A Case Series.
    Tremor Other Hyperkinet Mov (N Y) 2017 11;7:435. Epub 2017 Jan 11.
    College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY, USA.
    Background: Cervical dystonia, also known as spasmodic torticollis, is a chronic disorder in which patients exhibit involuntary repetitive contractions of neck muscles resulting in abnormal postures or movements. Occasionally, there is also a dystonic head tremor. The underlying mechanisms for cervical dystonia and dystonic tremor are not clear, and treatments are limited. Read More

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