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Am J Phys Med Rehabil 2020 Jul 1. Epub 2020 Jul 1.

H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.

Objective: Clinical trials assessing the efficacy of botulinum toxin in treating recalcitrant lateral epicondylitis have demonstrated varied results and differed greatly in methodology. The objective of this systematic review is to demonstrate injection location as a significant contributor to outcome heterogeneity.

Design: Two reviewers independently conducted a systematic review using Scopus, Embase, and Pubmed for randomized controlled trials assessing botulinum toxin in the treatment of lateral epicondylitis. Read More

Clin Neuropharmacol 2020 Jun 30. Epub 2020 Jun 30.

Naval Postgraduate Dental School and Uniformed Services University of the Health Sciences, Postgraduate Dental College, Bethesda, MD.

Trigeminal neuralgia is a pain condition that is frequently misdiagnosed and challenging to manage. We present the case of a patient with trigeminal neuralgia with multiple misdiagnoses and poorly managed pain. Despite the presence of trigger zones both inside and outside her mouth, complete symptom resolution was ultimately achieved through onabotulinumtoxinA injections, delivered solely intraorally. Read More

Clin Pharmacol 2020 26;12:75-81. Epub 2020 Jun 26.

Department of Urology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Recent investigations showed that anticholinergic drugs could use for the management of storage symptoms after transurethral resection of the prostate (TURP). The use of intravesical botulinum toxin-A (BTX-A) for the management of overactive bladder is rapidly increasing. In this research, we assess the efficacy of BTX-A vs solifenacin in men suffering from bladder outlet obstruction-over active bladder (BOO-OAB) managed with TURP. Read More

Eur Urol Focus 2020 Jun 29. Epub 2020 Jun 29.

Department of Urology, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK. Electronic address:

Context: Botulinum toxin A (BTX-A) injections are effective in managing refractory overactive bladder (OAB). However, some patients exhibit a poor response and/or experience adverse events (AEs) such as voiding dysfunction necessitating clean intermittent self-catheterisation (CISC) and urinary tract infections (UTIs).

Objective: To systematically evaluate whether poor response/AEs to BTX-A for idiopathic OAB are predictable. Read More

BMC Pediatr 2020 Jul 2;20(1):324. Epub 2020 Jul 2.

Physiotherapy Program, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, 4229, Australia.

Background: Lower limb serial casting is commonly used therapeutically in paediatric clinical practice with some evidence to support its efficacy. This systematic review aimed to determine the effects of serial casting in isolation or combination with other therapies for the management of lower limb dysfunction in children with Cerebral Palsy (CP).

Methods: A systematic literature search was conducted in February 2019 across eight databases (PUBMED, EMBASE, CINAHL, PEDro, OTSeeker, Cochrane, Scopus and Proquest) using key terms 'Cerebral Palsy' and 'serial casting' and associated synonyms. Read More

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):456-469. Epub 2020 Jun 24.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: We investigated RNA sequencing-based transcriptome profiling and the transformation of mature osteoblasts into bone lining cells (BLCs) through a lineage tracing study to better understand the effect of mechanical unloading on bone loss.

Methods: Dmp1-CreERt2(+):Rosa26R mice were injected with 1 mg of 4-hydroxy-tamoxifen three times a week starting at postnatal week 7, and subjected to a combination of botulinum toxin injection with left hindlimb tenotomy starting at postnatal week 8 to 10. The animals were euthanized at postnatal weeks 8, 9, 10, and 12. Read More

Gait Posture 2020 Jun 20;80:347-360. Epub 2020 Jun 20.

Department of Orthopaedics, Queensland Children's Hospital, QLD 4101, Australia.

Background: The optimal management of impaired knee joint function in patients with cerebral palsy (CP) remains a significant and ongoing challenge in paediatric orthopaedic surgery.

Research Question: What are the clinical and functional outcomes after operative and non-operative orthopaedic interventions for knee joint impairment in patients with CP?

Methods: This systematic review and meta-analysis of orthopaedic interventions for the management of knee joint impairment in paediatric CP patients evaluated study-level data in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. We performed searches of the following electronic databases from their dates of inception to November 2019: Medline (Ovid), Embase (Ovid) and Pubmed. Read More

J Cosmet Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical and Preventive Technologies for Public Health Risk Management Nizhny Novgorod Research, Institute of Hygiene and Occupational Pathology of the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, 20 Semashko Str., Nizhny Novgorod, 603105, Russian Federation.

Recently, both doctors and patients, pay particular attention to aesthetic medical services quality as well as efficacy of aesthetic adjustment implemented. It is essential to ensure research, analysis and improving of botulinum toxin therapy quality, and provide patients' orientation on the adjustment schedule, which includes long-term observation period, in order to accomplish the expected goals and increase degree of satisfaction. Injections of medication like botulinum A toxin are highly-demanded in many types of aesthetic treatment. Read More

J Cutan Med Surg 2020 Jul 1:1203475420937963. Epub 2020 Jul 1.

36639 Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Background: Scars with poor cosmesis that develop after wound healing may affect normal life.

Objective: To assess the efficacy and safety of botulinum toxin type A (BTXA) in preventing postoperative hypertrophic scars or keloids.

Methods: A systematic review was performed by searching the PubMed, Cochrane Library, and EMBASE databases from their inception date up to February 2020 for randomized controlled trials (RCTs) evaluating the efficacy of BTXA in preventing hypertrophic scars or keloids. Read More

Neuropsychiatr Dis Treat 2020 12;16:1505-1518. Epub 2020 Jun 12.

Department of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Katowice, Poland.

Cerebral palsy (CP) is one of the most frequent causes of motor disability in children. According to the up-to-date definition, CP is a group of permanent disorders of the development of movement and posture, causing activity limitations that are attributed to non-progressive disturbances that occurred in the developing foetal or infant brain. The CP definition has evolved over time; the problem is aetiologically and clinically very heterogeneous. Read More

Ann Indian Acad Neurol 2020 May-Jun;23(3):344-347. Epub 2020 Jun 10.

Department of Neurosurgery, Teikyo University Mizonokuchi Hospital, Takatsu-ku, Kawasaki, Department of Neurosurgery, Saitama Neurosurgical Institute, Konosu, Saitama, Japan.

Objective: Onabotulinum toxin A (botulinum A toxin) is utilized to extend flexed extremities in spastic hemiparesis. Injection points are important to obtain a better effect. Injecting botulinum A toxin into the forearm muscles is a standard method for flexed wrist and fingers; however, we developed new injection points in the intrinsic muscles of the hand to acquire more reliable effect. Read More

Arch Oral Biol 2020 Jun 12;117:104817. Epub 2020 Jun 12.

Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Objectives: To investigate the effect and mechanism of botulinum neurotoxin type A (BoNT/A) in the modulation of orofacial nociception induced by orthodontic tooth movement in rats.

Methods: An orofacial nociception model was established in male Sprague-Dawley rats by ligating closed-coil springs between incisors and ipsilateral molars. There were two group sets of animals. Read More

Neurol Neurochir Pol 2020 ;54(3):218-219

Mayo Clinic Florida, 4500 San Pablo Rd S, 32224 Jacksonville, United States.

Introduction: Cervical dystonia is a form of focal dystonia characterised by tilting and turning of the head and neck. This can cause significant disability in affected patients. Botulinum toxin injections are the mainstay of therapy. Read More

J Pediatr 2020 Jun 26. Epub 2020 Jun 26.

Aerodigestive Center, Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Hepatology & Nutrition, Boston Children's Hospital, Boston, MA. Electronic address:

Objective: To determine the effectiveness of intrapyloric botulinum toxin injection (IPBI) for treatment of feeding disorders and associated gastrointestinal symptoms in very young children.

Study Design: A single-center retrospective study of patients 2 months to 5 years old who received IPBI at Boston Children's Hospital from May 2007 to June 2019 was performed. Charts were reviewed for demographic data, comorbidities, symptoms leading to IPBI, oral and tube feeding data, symptom improvement after IPBI, and need for repeat injections. Read More

Urology 2020 Jun 26. Epub 2020 Jun 26.

Department of Urology, Weill Cornell Medical College, New York, NY. Electronic address:

Acta Obstet Gynecol Scand 2020 Jun 29. Epub 2020 Jun 29.

Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Introduction: Botulinum toxin has proven therapeutic effects in alleviating pain in several myofascial disorders, with an expanding potential in chronic pelvic pain. The objective of this systematic review is to evaluate the efficacy and safety of botulinum toxin injection as an off-label treatment for female chronic pelvic pain.

Material And Methods: Using PRISMA guidelines, MEDLINE, EBM Reviews, PubMed, CINAHL, TRIP Database, EMBASE, Web of Science and gray literature were searched. Read More

J Voice 2020 Jun 25. Epub 2020 Jun 25.

Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Objective: Vocal process granuloma (VPG) has a varied treatment success rate and may frustrate patients and physicians due to poor outcomes. There is still a lack of standard protocols to manage VPG. This study aimed to review the efficiency of a standardized low-dose laryngeal electromyographic (LEMG)-guided botulinum toxin A (BTA) injection in intractable vocal granulomas. Read More

Acta Neurol Belg 2020 Jun 27. Epub 2020 Jun 27.

Department of Neurology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.

Oromandibular dystonia (OMD) is a clinically and etiologically heterogeneous form of focal dystonia with variable social and functional implications. The results of pharmacological treatment and botulinum toxin infiltrations are often unsatisfactory. We performed a systematic review on the effects of oral and dental appliances in patients with OMD. Read More

Urology 2020 Jun 24. Epub 2020 Jun 24.

J Cosmet Dermatol 2020 Jun 27. Epub 2020 Jun 27.

Center for Clinical and Cosmetic Research, 2925 Aventura Blvd., Suite 205, Aventura, FL, 33180, United States.

The globally devastating effects of COVID-19 breach not only the realm of public health, but of psychosocial interaction and communication as well, particularly with the advent of mask-wearing. Today, the mask has become a semi-permanent accessory to the face, blocking our ability to express and perceive each other's facial expressions by dividing it into a visible top-half and invisible bottom-half. This significantly restricts our ability to accurately interpret emotions based on facial expressions and strengthens our perceptions of negative emotions produced by frowning. Read More

Dermatol Ther (Heidelb) 2020 Jun 26. Epub 2020 Jun 26.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Introduction: Intradermal injection of botulinum toxin type A (BoNT/A) has been used off-label by many clinicians for face-lifting. Previous studies on abobotulinumtoxinA (ABO) (Dysport®; Ipsen Biopharm Ltd.) have demonstrated clinical efficacy in face-lifting when compared to normal saline solution (NSS). Read More

Reumatol Clin 2020 Jun 23. Epub 2020 Jun 23.

Rheumatology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia, Portugal.

Introduction: In systemic sclerosis (SSc), peripheral vasculopathy presents typically as Raynaud Phenomenon (RP) and Digital Ulceration (DU). Over the last decade, botulinum toxin (BT) has been reported effective in this scenario. Our goal was to review existing literature evaluating the efficacy of BT on RP/DU in SSc. Read More

Plast Reconstr Surg 2020 Jul;146(1):157-170

New York, N.Y. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Mount Sinai Hospital.

Background: Since their introduction to clinical medicine in 1989, botulinum toxin injections have been used for many indications. First used for nonsurgical management of strabismus, botulinum toxin injections are now widely used in plastic and reconstructive surgery for aesthetic indications; however, nonaesthetic indications of botulinum toxin have grown tremendously over the past two decades and span numerous specialties, including urology, dermatology, ophthalmology, otolaryngology, gynecology, plastic surgery, general surgery, and neurology. The present review aims to highlight nonaesthetic indications of botulinum toxin that are most relevant to the plastic surgeon with an emphasis on evidence-based practice. Read More

J Neurosurg Spine 2020 Jun 26:1-9. Epub 2020 Jun 26.

1Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; and.

Objective: Selective peripheral denervation (SPD) is a widely accepted surgery for medically refractory cervical dystonia (CD), but when SPD has failed, the available approaches are limited. The authors investigated the results from a cohort of CD patients treated with unilateral pallidotomy after unsatisfactory SPD.

Methods: The authors retrospectively analyzed patients with primary CD who underwent unilateral pallidotomy after SPD between April 2007 and August 2019. Read More

J Neural Transm (Vienna) 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

To explore the correlations of botulinum toxin (BT) therapy with dysphagia, we wanted to study a group of cervical dystonia (CD) patients with optimised BT therapy during a prolonged period of time to record their dysphagia frequency, severity and duration, to study potential risk factors and try to avoid it by BT application with ultrasound guidance. BT therapy of 75 CD patients (23 males, 52 females, age 60 ± 12 years, BT total dose 303.5 ± 101. Read More

Front Neurol 2020 10;11:513. Epub 2020 Jun 10.

Assistant Professor of Neurology, Department of Neurology, University of Missouri, Columbia, MO, United States.

Drooling related to bulbar weakness and dysfunction is a common concern in patients with neuromuscular disease. While there are numerous medications to manage sialorrhea, they are often limited by side effects and lack of efficacy. Botulinum toxin has shown to benefit ALS patients in a few studies, but there is scant data on the benefit in other neuromuscular conditions. Read More

Headache 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurology, St. Olav's University Hospital, Trondheim, Norway.

Background: The otic ganglion (OG) provides parasympathetic innervation to the cerebral circulation and cranial structures and may be involved in the pathophysiology of trigeminal autonomic headaches. This structure has never been targeted in any headache disorder.

Objective: To investigate the safety of injecting onabotulinumtoxin A (BTA) toward the OG in 10 patients with intractable chronic cluster headache and to collect efficacy data. Read More

Cureus 2020 May 22;12(5):e8235. Epub 2020 May 22.

Dermatology, University of Central Florida College of Medicine, Orlando, USA.

Raynaud's phenomenon (RP) is a relatively common syndrome occurring alone or in combination with autoimmune and inflammatory diseases. It is characterized by pain and ulceration due to vasospasm in response to cold and stress, most often affecting the digits. Although pharmacologic treatment for this condition exists, it is not always efficacious. Read More

Front Neurol 2020 2;11:378. Epub 2020 Jun 2.

Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.

While Botulinum NeuroToxin-A (BoNT-A) injections are frequently used to reduce the effects of hyperactive stretch reflexes in children with cerebral palsy (CP), the effects of this treatment vary strongly. Previous research, combining electromyography (EMG) with motion analysis, defined different patterns of stretch reflex muscle activation in muscles, those that reacted more to a change in velocity (velocity dependent -VD), and those that reacted more to a change in length (length dependent -LD). The aim of this study was to investigate the relation between the types of stretch reflex muscle activation in the semitendinosus with post-BoNT-A outcome as assessed passively and with 3D gait analysis in children with spastic CP. Read More

Front Neurosci 2020 4;14:325. Epub 2020 Jun 4.

Severe Developmental Disabilities Unit, Scientific Institute, IRCCS Eugenio Medea, Conegliano, Italy.

Hereditary spastic paraplegias (HSP) are a group of genetically and clinically heterogeneous neurologic disorders. Hereby we describe a relatively large group of patients (pts) affected by HSP studied at baseline (31 pts) and at follow-up (mean period 28.9 ± 8. Read More

J Pain Res 2020 3;13:1297-1304. Epub 2020 Jun 3.

Canadian Centre of Integrative Medicine, Toronto, ON, Canada.

Introduction: There is a paucity of long-term treatment benefit and safety data of botulinum toxin A (BTX-A) for cervical dystonia (CD) and myofascial neck pain syndrome (MPS). Additionally, the prevalence of adjunct modality uses during this period is unknown despite evolving practices.

Objective: To assess and compare treatment benefit, safety, and adjunct modality prevalences of long-term BTX-A injections between CD and MPS patients. Read More

J Child Neurol 2020 Jun 24:883073820931256. Epub 2020 Jun 24.

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Aims: To conduct a review of the literature on the use of botulinum toxin for the treatment of pediatric chronic migraine.

Methods: A review of the literature was performed using EMBASE, PubMed, and Cochrane/Ovid. Using our inclusion and exclusion criteria, we targeted any study, published before April 2020, evaluating the efficacy of botulinum toxin in migraineurs younger than 18 years. Read More

PM R 2020 Jun 23. Epub 2020 Jun 23.

Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Adjunct therapies are non-pharmacological treatments used with botulinum toxin (BoNT) injection that may improve spasticity outcomes. It has been suggested that physicians consider adjunct therapies as a part of comprehensive spasticity management. It is unclear which adjunct therapies are used by physicians in clinical practice. Read More

Surgery 2020 Jun 20. Epub 2020 Jun 20.

Unit of Abdominal Wall Surgery, Department of Digestive Surgery, "La Fe" Hospital, University of Valencia, Valencia, Spain.

Background: The goal of our study was to compare results in patients with large midline incisional hernia using modified anterior component separation versus preoperative botulinum toxin and following Rives repair, with a focus on surgical site occurrences, possibility of fascial closure, duration of hospital stay, and hernia recurrence rate.

Methods: From to March 2016 to June 2019, a prospective comparative study was performed in 80 consecutive patients with large midline incisional hernias and hernia transverse diameters between 11 and 17 cm under elective hernia repair at our tertiary center. Two groups were analyzed prospectively: 40 patients with preoperative botulinum toxin administration and following open Rives repair (botulinum toxin group) were compared with 40 patients who underwent open component separation during that period (component separation group). Read More

J Pediatr Surg 2020 May 23. Epub 2020 May 23.

Department of Urology, Guangdong Provincial Work Injury Rehabilitation Hospital, Guangzhou, China, 510440. Electronic address:

Objective: To evaluate the efficacy and safety of trigonal botulinum toxin A (BTX-A) injections for children with neurological detrusor overactivity (NDO) secondary to spinal cord injury (SCI).

Methods: From February 2012 to December 2018, children with NDO secondary to SCI were enrolled. All patients received 200U BTX-A intradetrusor injections including the trigone. Read More

Otolaryngol Head Neck Surg 2020 Jun 23:194599820931470. Epub 2020 Jun 23.

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, USA.

Objective: There is little consensus regarding the efficacy and safety of treatment options for cricopharyngeal (CP) achalasia. The purpose of this scoping review is to assess the literature regarding the various treatments for this disease.

Data Sources: PubMed was searched for all articles addressing treatment of adult CP achalasia between January 1990 and June 2019. Read More

Medicine (Baltimore) 2020 Jun;99(25):e20702

Third Ward of Neurology Department, First Affiliated Hospital of Jiamusi University, Jiamusi, China.

Background: This protocol aims to assess the efficacy and safety of Botulinum Toxin Type A (BTTA) for the treatment of neuropathic pain (NPP) in patients with spinal cord injury (SCI).

Methods: We will retrieve databases in Cochrane Library, EMBASE, MEDLINE, Excerpta Medica Database, PsychINFO, the Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from the beginning to the March 1, 2020. We will consider any potential studies on assessing the efficacy and safety of BTTA for the treatment of NPP in patients with SCI without limitations of language and publication status. Read More

J Pediatr Rehabil Med 2020 Jun 12. Epub 2020 Jun 12.

Department of Rehabilitation and Regenerative Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Recent studies have generally shown favorable outcomes for the use of botulinum toxin (BoNT) injections for the treatment of lower extremity spasticity in children with cerebral palsy. The randomized controlled trials and placebo trials are well described although even those and other studies show high variability in methodology for use of BoNT. This raises questions about which strategies are the most effective. Read More

J Pediatr Rehabil Med 2020 Jun 12. Epub 2020 Jun 12.

Botulinum toxins (BoNT) are a standard of care for spasticity management of children with a variety of neuromuscular (NM) conditions. BoNT relaxes skeletal muscles by inhibiting the release of acetylcholine from the neuromuscular junction (NMJ). As part of their training physiatrist become proficient in the targeted injections of BoNT into affected skeletal musculature. Read More

J Pediatr Rehabil Med 2020 Jun 12. Epub 2020 Jun 12.

Dis Esophagus 2020 Jun 22. Epub 2020 Jun 22.

Division of Gastroenterology and Hepatology, Mayo Clinic Arizona.

Distal esophageal spasm (DES) is a motility disorder characterized by premature contraction of the esophageal body during single swallows. It is thought to be due to impairment of esophageal inhibitory pathways, but studies to support this are limited. The normal response to multiple rapid swallows (MRS) is deglutitive inhibition of the esophageal body during the MRS sequence. Read More

Curr Drug Targets 2020 Jun 21. Epub 2020 Jun 21.

2ndDepartment of Urology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki. Greece.

Intravesical Botox has become a widespread treatment for patients with refractory overactive bladder. Further to its acknowledged efficacy, both physicians and patients must be fully aware of possible complications, such as urinary tract infections, incomplete bladder emptying or even urinary retention and possible need for intermittent selfcatheterizations, fatigue, muscle weakness, transient hematuria and autonomic dysreflexia. Careful patient selection, particularly in terms of comorbidities, caution with technical aspects of the procedure such as the use of fine specifically designed injection needles, treatment of baseline UTIs or bacteriuria, avoidance of bladder overfilling could be the main measures, in addition to rigorous patient follow-up, to minimize the risk of post-Botox UTIs, hematuria, autonomic dysreflexia, and retention. Read More

Int J Food Microbiol 2020 May 29;331:108697. Epub 2020 May 29.

Institute for Food Safety and Health (IFSH), 6502 South Archer Road, Bedford Park, IL, USA.

This research investigated the use of high-pressure processing (HPP) for inactivating vegetative pathogens and spoilage microbiota in fresh unfiltered coconut water (Cocos nucifera L) from nuts obtained from Florida and frozen CW from Brazil with pH >5.0 and storage at 4 °C. Additionally, CW was evaluated to determine if it supported the growth and toxin production of Clostridium botulinum with or without the use of HPP when stored at refrigeration temperatures. Read More

Handb Exp Pharmacol 2020 Jun 20. Epub 2020 Jun 20.

Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.

Botulinum toxin injection has been widely accepted by the urology and urogynecology medical communities as a safe and effective treatment for refractory urinary incontinence. There are two approved genitourinary indications for botulinum toxin. OnabotulinumtoxinA (onaBoNTA) 200 U for the treatment of urinary incontinence due to detrusor overactivity associated with a neurologic condition (e. Read More

Handb Exp Pharmacol 2020 Jun 20. Epub 2020 Jun 20.

Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA, USA.

Tremendous progress has been made in the past decades for the treatment of headache disorders. Chronic migraine is the most disabling type of headache and requires the use of acute and preventive medications, many of which are associated with adverse events that limit patient adherence. Botulinum toxin (BoNT) serotype A, a neurotoxin derived from certain strains of Clostridium, disrupts neuropeptide secretion and receptor translocation related to trigeminal nociception, thereby preventing pain sensitization through peripheral and possibly central mechanisms. Read More

Turk J Pediatr 2020 ;62(3):491-494

Department of Pediatric, Neurology, İzmir Katip Celebi University, İzmir.

Background: Dystonia is a common hyperkinetic movement disorder in children; however, making an early and definitive diagnosis of dystonia can sometimes be challenging for clinicians.

Case: Herein, we report a case of a 16 years-old girl presenting with laryngeal dystonia due to compound heterozygosity of a known pathogenic and a novel variant in the ATM gene. Serum alpha-fetoprotein level was elevated. Read More

J Cosmet Dermatol 2020 Jun 18. Epub 2020 Jun 18.

Department of Plastic and Reconstructive Surgery, College of Medicine, Yonsei University, Seoul, South Korea.

Background: Deviated noses and asymmetric nostrils can be corrected using corrective rhinoplasty. However, after proper correction, adjacent facial mimetic muscles can cause recurrence of asymmetry because of preoperative habits.

Objectives: We performed this study to investigate the effects on botulinum toxin on the prevention of recurrence of asymmetry after corrective rhinoplasty. Read More

Lasers Med Sci 2020 Jun 17. Epub 2020 Jun 17.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand.

Intradermal injections of botulinum toxin type A (BTX-A) have been used successfully to treat patients with primary palmoplantar hyperhidrosis (PPH). However, problems with local injections of BTX-A for palmar hyperhidrosis include injection pain and reduced palmar muscle strength. This case series describes three patients with PPH. Read More

Int Urogynecol J 2020 Jun 18. Epub 2020 Jun 18.

Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, 707, Sec. 3, Chung-Yang Rd., Hualien, Taiwan.

Introduction And Hypothesis: We report long-term changes in VUDS profiles of women with dysfunctional voiding and investigate potential predictors for treatment response.

Methods: Women with dysfunctional voiding and available VUDS data between November 1997 and June 2018 were enrolled for retrospective analysis. The patients were all treated with medication first. Read More

J Rehabil Med 2020 Jun 30;52(6):jrm00076. Epub 2020 Jun 30.

Blanquerna School of Health Science, Ramon Llull University, Barcelona, Spain.

Objectives: To investigate whether botulinum toxin type A (BTX-A) injection is more effective than radial extracorporeal shock wave therapy in reducing plantar flexor muscle spasticity in subjects with cerebral palsy.

Methods: A total of 68 subjects with cerebral palsy were randomly allocated to BTX-A injection (Group 1) or radial extracorporeal shock wave therapy (Group 2) (first experiment; E1). Outcome was evaluated using the Tardieu V1 and V3 stretches, at 3 weeks, 2 months (M2) and M3 after baseline. Read More