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Clin Cosmet Investig Dermatol 2022 8;15:609-619. Epub 2022 Apr 8.

Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Purpose: Central centrifugal cicatricial alopecia (CCCA) is the most common cause of scarring alopecia in women of African descent. However, current treatments for CCCA, such as immunosuppressants and immunomodulatory pharmaceutical agents, have suboptimal efficacy and undesirable side effects. This case series reports the therapeutic effect of a new botanical formulation (Dr. Read More

Curr Pharm Biotechnol 2022 Mar 24. Epub 2022 Mar 24.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China.

Background: The medicinal properties of plants can be predicted by virtue of phylogenetic methods, which nevertheless has not been utilized to explore the regularity of skin related bioactivities of ethnomedicinal plants. We aim to investigate the distribution of skin efficacy of Asteraceae and Ranunculales plants on the species-level Tree of Life.

Methods: The clinical efficacy data of 551 ethnomedicinal species belonging to Ranunculales, as well as 579 ethnomedicinal species of Asteraceae, were systematically collected and collated; these therapeutic data fell into 15 categories, including skin disease/cosmeceutical. Read More

Front Pharmacol 2022 21;13:826716. Epub 2022 Feb 21.

Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Although platinum-based chemotherapeutics such as cisplatin are the cornerstone of treatment for ovarian cancer, their clinical application is profoundly limited due to chemoresistance and severe adverse effects. Sporoderm-broken spores of (SBSGL) have been reported to possess antitumor effects. However, the function and mechanism of SBSGL and its essential composition, ganoderic acid D (GAD), in the cisplatin therapy on ovarian cancer have yet to be investigated. Read More

J Cosmet Dermatol 2022 Mar 2. Epub 2022 Mar 2.

Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.

Background: Mutation in the lipase H (LIPH) gene is a main reason for autosomal recessive woolly hair (ARWH)/hypotrichosis. Although some studies reported that topical minoxidil could improve ARWH, an effective treatment method for this disease is still lacking.

Aim: We attempt to explore potential treatment options for ARWH. Read More

Dermatol Pract Concept 2022 Feb 1;12(1):e2022029. Epub 2022 Jan 1.

Department of Dermatology, McGovern Medical School at University of Texas Health Science Center at Houston, Houston, TX, USA.

Introduction: As no centralized database of acne supplements is available, we aimed to provide an overview of these products, with a focus on safety.

Objectives: The objectives of this study were to document the number, formulation, contents, and marketing strategies utilized by acne supplements sold online.

Methods: An online search was conducted between March and May 2020. Read More

Biology (Basel) 2022 Feb 20;11(2). Epub 2022 Feb 20.

Department of Food and Nutrition, Providence University, 200, Section 7, Taiwan Boulevard, Shalu District, Taichung City 43301, Taiwan.

Oyster shell waste has led to many problems, including displeasing odors, pollution of the seaside, and harm to the environment. Using calcined oyster shells as a natural preservative might solve the problem of oyster shell waste. We studied the use of calcined oyster shell powder (COSP) as a natural preservative for improving shrimp shelf-life over 12 days under refrigerated conditions. Read More

Cutis 2021 Nov;108(5):251-253

Ms. Flanagan is from the University of Massachusetts Chan Medical School, Worcester. Drs. Blankenship and Houk are from the Department of Dermatology, University of Massachusetts, Worcester.

Giant hogweed (Heracleum mantegazzianum) is an invasive flowering weed that can reach a height of 13 feet. Although it is the appearance of the plant that can draw attention, contact with the sap in combination with exposure to the sun can result in severe phytophotodermatitis. Due to the growing prevalence of giant hogweed, the number of cases of H mantegazzianum-associated phytophotodermatitis in the United States is increasing. Read More

Cutis 2021 Oct;108(4):212-214

Dr. Schwartzberg is from the Department of Medicine, Lehigh Valley Health Network, Allentown, Pennsylvania. Dr. Osswald is from the Department of Dermatology and Cutaneous Surgery, UT Health San Antonio, Texas. Dr. Elston is from the Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston.

Bloodroot (Sanguinaria canadensis) is a plant that historically has been used in medicine for its antimicrobial, antihypertensive, anti-inflammatory, and antineoplastic properties. In dermatology, bloodroot has been utilized for its cytotoxic effects; it has been marketed as black salve as an anticancer treatment, but it does not come without notable toxicities. Unwanted cosmetic outcomes and even irreversible scarring and premalignant conditions have been reported. Read More

Int J Food Sci Nutr 2022 Jun 31;73(4):460-470. Epub 2021 Oct 31.

School of Biotechnology and Health Sciences, Wuyi University, International Healthcare Innovation Institute (Jiangmen), Jiangmen, China.

Oleuropein (OLE) and hydroxytyrosol (HT) are dietary polyphenols with skin beneficial effects but their effects on skin-ageing-related enzymes are not clear. Herein, we evaluated their inhibitory effects on elastase and collagenase. OLE and HT (62. Read More

Biology (Basel) 2021 Oct 11;10(10). Epub 2021 Oct 11.

Department of Food and Nutrition, Providence University, 200, Section 7, Taiwan Boulevard, Shalu District, Taichung 43301, Taiwan.

Palmyra palm syrup, produced from flowers' sap, is rich in nutrients and minerals and has unique flavors. This study evaluated the in vitro antioxidant activity, physicochemical characteristics, and Maillard reaction products of palmyra palm syrup prepared by thermal and ultrafiltration processes. Palmyra palm syrup prepared by a thermal process had smaller L*, b* values, and larger a* values than that prepared by an ultrafiltration process. Read More

Contact Dermatitis 2022 01 25;86(1):67-69. Epub 2021 Oct 25.

BoDD-Botanical Dermatology Database, Penarth, UK.

J Cosmet Dermatol 2022 Jan 26;21(1):85-98. Epub 2021 Sep 26.

Department of Dermatology, Venereology and Leprosy, Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi, India.

Background: While a plethora of literature continues to be published on the role of nutritional agents both in lay press and indexed journals, the data is not on a firm footing and leaves the dermatologist in a quandry and the patient confused. The various agents include vitamins, minerals, amino acids, antioxidants, diets & gluten. A proper knowledge of the role of nutritional supplements in dermatological diseases can be a useful tool in advising the patients and in certain cases ameliorating the disorder. Read More

J Cosmet Dermatol 2022 May 21;21(5):2064-2072. Epub 2021 Jul 21.

Master of Science Program in Anti-Aging & Regenerative Medicine, College of Integrative Medicine, Dhurakij Pundit University, Bangkok, Thailand.

Background: Skin aging is one of the most concerning issues during the post-menopausal period. Despite the promising effects of hormonal therapy, there is still concerned about the long-term outcomes from the treatment. Therefore, nutraceuticals that contain estrogenic and antioxidative effects have gained a lot of attention as an alternative therapy for slowing down skin age-related changes in women after menopause. Read More

Plants (Basel) 2021 Jun 14;10(6). Epub 2021 Jun 14.

Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary.

Ingenol mebutate, isolated from , is an ingenane-type diterpenoid, primarily used for the topical treatment of actinic keratosis, a premalignant skin condition. The aim of our work was to investigate other species to find structurally similar diterpenes that can be used as alternatives to ingenol mebutate. Pharmacological investigation of , , , and revealed the potent keratinocyte (HPV-Ker cell line) inhibitory activity of these spurge species. Read More

Indian J Dermatol 2021 Mar-Apr;66(2):117-125

Department of Dermatology, Venereology, and Leprosy, Medical College and Hospitals, Kolkata, 88, College Street, Kolkata, West Bengal, India.

Topical antibacterials are commonly used for superficial pyodermas such as impetigo and treatment or prevention of infections following minor cuts, abrasions, burns, and surgical wounds. Several antibiotics and antiseptics are available for use in different indications. One of the major uses of topical antibacterials is acne in which benzoyl peroxide is the drug of the first choice either singly or in combination with antibiotics or retinoids. Read More

N Z Med J 2021 06 4;134(1536):86-99. Epub 2021 Jun 4.

Department of Medicine, University of Auckland, Auckland, New Zealand; Department of Dermatology, Auckland City Hospital, Auckland, New Zealand.

Background: Contact allergy to plants, particularly Compositae, presents with dermatitis and is diagnosed with skin patch testing. Sesquiterpene lactone mix is a common screening allergen for plant allergy. The rate of plant allergen sensitisation in New Zealand, which is affected by local horticultural factors, has not previously been documented. Read More

Cutis 2021 Apr;107(4):187-189

Rutgers New Jersey Medical School, Newark. Dr. Schwartz from the Departments of Dermatology, Pathology, Pediatrics, and Medicine. Mr. Janusz also is from Saint Joseph University, Philadelphia, Pennsylvania.

Phytophotodermatitis (PPD) is a toxic reaction resulting from contact with a photosensitizing botanical chemical followed by exposure to solar or artificial UV light. It may present with bizarre patterns and linear streaks due to a phototoxic agent splashing onto various cutaneous sites; thus, it affects the skin at points of contact and exposure to UV light. Individuals typically experience symptoms within 24 hours of exposure. Read More

J Nat Prod 2021 05 6;84(5):1563-1572. Epub 2021 May 6.

Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, United States.

Preclinical and clinical studies support cannabidiol (CBD)'s antioxidant and anti-inflammatory effects, which are linked to its skin protective effects, but there have been limited mechanistic studies reported. Herein we evaluated CBD's protective effects against hydrogen peroxide (HO)-induced oxidative stress in human keratinocyte HaCaT cells and explored its possible mechanism(s) of action. CBD (10 μM) protected HaCaT cells by alleviating HO (200 μM)-induced cytotoxicity (by 11. Read More

Cells 2021 04 6;10(4). Epub 2021 Apr 6.

2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, 15-276 Bialystok, Poland.

Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic causative factors of aging. Intrinsic aging is related to compromised cellular proliferative capacity, and may be accelerated by harmful environmental influences with the greatest significance of ultraviolet radiation exposure, contributing not only to premature aging, but also to skin carcinogenesis. The overall skin cancer burden and steadily increasing global antiaging market provide an incentive for searching novel targets to improve skin resistance against external injury. Read More

Biomolecules 2021 03 2;11(3). Epub 2021 Mar 2.

Research Center skinitial, Department of Dermatology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation of keratinocytes and expression of pro-inflammatory cytokines in the epidermis. New biological drugs were developed for the systemic treatment of moderate to severe psoriasis. However, products for the topical treatment of mild psoriasis are still required. Read More

Phytother Res 2021 Aug 16;35(8):4136-4154. Epub 2021 Mar 16.

Khoy University of Medical Sciences, Khoy, Iran.

Cosmetic dermatology preparations such as bleaching agents are ingredients with skin-related biological activities for increasing and improving skin beauty. The possibility of controlling skin hyperpigmentation disorders is one of the most important research goals in cosmetic preparations. Recently, cosmetics containing herbal and botanical ingredients have attracted many interests for consumers of cosmetic products because these preparations are found safer than other preparations with synthetic components. Read More

Autophagy 2021 Jan 8;17(1):1-382. Epub 2021 Feb 8.

University of Crete, School of Medicine, Laboratory of Clinical Microbiology and Microbial Pathogenesis, Voutes, Heraklion, Crete, Greece; Foundation for Research and Technology, Institute of Molecular Biology and Biotechnology (IMBB), Heraklion, Crete, Greece.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Read More

Case Rep Dermatol Med 2021 4;2021:6659943. Epub 2021 Feb 4.

Strategic Solutions, Inc., Bozeman, MT, USA.

. Current approved medications for hair loss, such as topical minoxidil and oral finasteride, may have suboptimal efficacy or side effects precluding continued use in some patients. Thus, we report an evaluation of the efficacy, safety, and tolerability of a new topical botanical formulation -GASHEE containing over 12 phytoactive ingredients that affect multiple targets in the cascade of pathophysiologic events that cause hair loss. Read More

J Cosmet Dermatol 2021 Feb 21;20(2):522-525. Epub 2020 Dec 21.

Chapel Hill Dermatology, Chapel Hill, NC, USA.

Introduction: UV-induced oxidative skin stress leads to cutaneous photoaging. The objective of these 2 studies was to evaluate a nature-based botanical facial oil for the ability to decrease UV-induced oxidative skin stress.

Methods: 22 females were enrolled in the UVA study, and 10 females were enrolled in the UVB study. Read More

Skin Appendage Disord 2020 Nov 23;6(6):329-337. Epub 2020 Aug 23.

Department of Dermatology, University of California, Irvine, Irvine, California, USA.

Saw palmetto (SP), a botanical extract with antiandrogenic properties, has gained commercial popularity for its purported benefits on hair regrowth. To summarize published evidence on the efficacy, safety, and tolerability of supplements containing SP in the treatment of alopecia, we conducted a PubMed, Google Scholar, and Cochrane database search using the following terms: (saw palmetto and hair loss), (saw palmetto and androgenetic alopecia), and (saw palmetto and natural supplement and alopecia). Five randomized clinical trials (RCTs) and 2 prospective cohort studies demonstrated positive effects of topical and oral supplements containing SP (100-320 mg) among patients with androgenetic alopecia (AGA) and telogen effluvium. Read More

Dermatitis 2021 Jan-Feb 01;32(1):42-52

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles.

Importance: When fragrance- and botanical-related (F/BR) allergy is identified, concomitant reaction (CR) frequencies can help direct avoidance recommendations.

Objective: This study aimed to determine the CR rates for F/BR allergens.

Design: A retrospective cross-sectional analysis of the North American Contact Dermatitis Group data 2007-2016 was conducted. Read More

J Clin Aesthet Dermatol 2020 Aug 1;13(8):23-27. Epub 2020 Aug 1.

Dr. Ezekwe is with the University of Mississippi Medical School in Jackson, Mississippi.

Central centrifugal cicatricial alopecia (CCCA), a scarring alopecia that commonly affects women of African descent, can be challenging to manage, and there are limited treatment modalities available. The use of natural ingredients for nonscarring hair loss has gained popularity among patients, but has not been previously studied for CCCA. We sought to review clinical studies evaluating the use of natural ingredients in the treatment of CCCA. Read More

Indian J Dermatol Venereol Leprol 2020 Nov-Dec;86(6):622-629

Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry University, Puducherry, India.

Humans have been anointing their skin with natural colorants since antiquity. Before the advent of modern cosmetics, tattoos and hair dyes, the spectacular colors in plants served as a palette for humanity's fascination with color. Skin, hair, nails, teeth and clothing have been altered with botanical colorants for centuries. Read More

J Ethnopharmacol 2021 Feb 2;266:113434. Epub 2020 Oct 2.

School of Pharmaceutical Sciences, Shoolini University, P.O. Box 9, Solan, Himachal Pradesh, 173229, India. Electronic address:

Ethnopharmacological Relevance: Hippophae rhamnoides L. (family- Elaeagnaceae, common name- Sea buckthorn) is a flowering shrub native to cold temperate regions of Eurasia. Berries, seeds, and leaves of the plant are widely used as a folk medicine for the treatment of hypertension, oedema, inflammation, tissue-regeneration, skin-grafts, burns/injury, wounds, and ulcers. Read More

Food Sci Nutr 2020 Sep 20;8(9):4857-4867. Epub 2020 Jul 20.

Department of Microbiology WU Lien-Teh Institute Harbin Medical University Harbin China.

Honey is thought to act against microbes and regulates microbiota balance, and this is mainly attributed to the enzymatic production of hydrogen peroxide, high osmolarity, and nonperoxidase factors, for example, lysozyme and botanical sources of nectar, while the effect of honey's probiotic is recently considered. The study of honey as source of beneficial microbes is understudied. The purpose of this study was to screen for the beneficial microorganisms in honey with antagonistic property against important pathogens and the mechanism of antimicrobial activity and thus play a beneficial role as probiotics. Read More