167 results match your criteria Botanical Dermatology


Cannabidiol Protects Human Skin Keratinocytes from Hydrogen-Peroxide-Induced Oxidative Stress via Modulation of the Caspase-1-IL-1β Axis.

J Nat Prod 2021 May 6. Epub 2021 May 6.

Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, United States.

Preclinical and clinical studies support cannabidiol (CBD)'s antioxidant and anti-inflammatory effects, which are linked to its skin protective effects, but there have been limited mechanistic studies reported. Herein we evaluated CBD's protective effects against hydrogen peroxide (HO)-induced oxidative stress in human keratinocyte HaCaT cells and explored its possible mechanism(s) of action. CBD (10 μM) protected HaCaT cells by alleviating HO (200 μM)-induced cytotoxicity (by 11. Read More

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Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging-A Systematic Review.

Cells 2021 Apr 6;10(4). Epub 2021 Apr 6.

2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, 15-276 Bialystok, Poland.

Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic causative factors of aging. Intrinsic aging is related to compromised cellular proliferative capacity, and may be accelerated by harmful environmental influences with the greatest significance of ultraviolet radiation exposure, contributing not only to premature aging, but also to skin carcinogenesis. The overall skin cancer burden and steadily increasing global antiaging market provide an incentive for searching novel targets to improve skin resistance against external injury. Read More

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The Effect of Herbal Medicinal Products on Psoriasis-Like Keratinocytes.

Biomolecules 2021 Mar 2;11(3). Epub 2021 Mar 2.

Research Center skinitial, Department of Dermatology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation of keratinocytes and expression of pro-inflammatory cytokines in the epidermis. New biological drugs were developed for the systemic treatment of moderate to severe psoriasis. However, products for the topical treatment of mild psoriasis are still required. Read More

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A comprehensive review of the therapeutic potential of α-arbutin.

Phytother Res 2021 Mar 16. Epub 2021 Mar 16.

Khoy University of Medical Sciences, Khoy, Iran.

Cosmetic dermatology preparations such as bleaching agents are ingredients with skin-related biological activities for increasing and improving skin beauty. The possibility of controlling skin hyperpigmentation disorders is one of the most important research goals in cosmetic preparations. Recently, cosmetics containing herbal and botanical ingredients have attracted many interests for consumers of cosmetic products because these preparations are found safer than other preparations with synthetic components. Read More

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Autophagy 2021 Jan 8;17(1):1-382. Epub 2021 Feb 8.

University of Crete, School of Medicine, Laboratory of Clinical Microbiology and Microbial Pathogenesis, Voutes, Heraklion, Crete, Greece; Foundation for Research and Technology, Institute of Molecular Biology and Biotechnology (IMBB), Heraklion, Crete, Greece.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Read More

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January 2021

A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases.

Case Rep Dermatol Med 2021 4;2021:6659943. Epub 2021 Feb 4.

Strategic Solutions, Inc., Bozeman, MT, USA.

. Current approved medications for hair loss, such as topical minoxidil and oral finasteride, may have suboptimal efficacy or side effects precluding continued use in some patients. Thus, we report an evaluation of the efficacy, safety, and tolerability of a new topical botanical formulation -GASHEE containing over 12 phytoactive ingredients that affect multiple targets in the cascade of pathophysiologic events that cause hair loss. Read More

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February 2021

Nature-based botanical facial oil oxidative stress protection.

J Cosmet Dermatol 2021 Feb 21;20(2):522-525. Epub 2020 Dec 21.

Chapel Hill Dermatology, Chapel Hill, NC, USA.

Introduction: UV-induced oxidative skin stress leads to cutaneous photoaging. The objective of these 2 studies was to evaluate a nature-based botanical facial oil for the ability to decrease UV-induced oxidative skin stress.

Methods: 22 females were enrolled in the UVA study, and 10 females were enrolled in the UVB study. Read More

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February 2021

Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia.

Skin Appendage Disord 2020 Nov 23;6(6):329-337. Epub 2020 Aug 23.

Department of Dermatology, University of California, Irvine, Irvine, California, USA.

Saw palmetto (SP), a botanical extract with antiandrogenic properties, has gained commercial popularity for its purported benefits on hair regrowth. To summarize published evidence on the efficacy, safety, and tolerability of supplements containing SP in the treatment of alopecia, we conducted a PubMed, Google Scholar, and Cochrane database search using the following terms: (saw palmetto and hair loss), (saw palmetto and androgenetic alopecia), and (saw palmetto and natural supplement and alopecia). Five randomized clinical trials (RCTs) and 2 prospective cohort studies demonstrated positive effects of topical and oral supplements containing SP (100-320 mg) among patients with androgenetic alopecia (AGA) and telogen effluvium. Read More

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November 2020

Fragrance- and Botanical-Related Allergy and Associated Concomitant Reactions: A Retrospective Analysis of the North American Contact Dermatitis Group Data 2007-2016.

Dermatitis 2021 Jan-Feb 01;32(1):42-52

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles.

Importance: When fragrance- and botanical-related (F/BR) allergy is identified, concomitant reaction (CR) frequencies can help direct avoidance recommendations.

Objective: This study aimed to determine the CR rates for F/BR allergens.

Design: A retrospective cross-sectional analysis of the North American Contact Dermatitis Group data 2007-2016 was conducted. Read More

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December 2020

The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic Review.

J Clin Aesthet Dermatol 2020 Aug 1;13(8):23-27. Epub 2020 Aug 1.

Dr. Ezekwe is with the University of Mississippi Medical School in Jackson, Mississippi.

Central centrifugal cicatricial alopecia (CCCA), a scarring alopecia that commonly affects women of African descent, can be challenging to manage, and there are limited treatment modalities available. The use of natural ingredients for nonscarring hair loss has gained popularity among patients, but has not been previously studied for CCCA. We sought to review clinical studies evaluating the use of natural ingredients in the treatment of CCCA. Read More

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For the love of color: Plant colors and the dermatologist.

Indian J Dermatol Venereol Leprol 2020 Nov-Dec;86(6):622-629

Department of Dermatology, Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry University, Puducherry, India.

Humans have been anointing their skin with natural colorants since antiquity. Before the advent of modern cosmetics, tattoos and hair dyes, the spectacular colors in plants served as a palette for humanity's fascination with color. Skin, hair, nails, teeth and clothing have been altered with botanical colorants for centuries. Read More

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October 2020

Ethnomedicinal uses, phytochemistry and dermatological effects of Hippophae rhamnoides L.: A review.

J Ethnopharmacol 2021 Feb 2;266:113434. Epub 2020 Oct 2.

School of Pharmaceutical Sciences, Shoolini University, P.O. Box 9, Solan, Himachal Pradesh, 173229, India. Electronic address:

Ethnopharmacological Relevance: Hippophae rhamnoides L. (family- Elaeagnaceae, common name- Sea buckthorn) is a flowering shrub native to cold temperate regions of Eurasia. Berries, seeds, and leaves of the plant are widely used as a folk medicine for the treatment of hypertension, oedema, inflammation, tissue-regeneration, skin-grafts, burns/injury, wounds, and ulcers. Read More

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February 2021

Antimicrobial and mechanism of antagonistic activity of sp. A2 against pathogenic fungus and bacteria: The implication on honey's regulatory mechanism on host's microbiota.

Food Sci Nutr 2020 Sep 20;8(9):4857-4867. Epub 2020 Jul 20.

Department of Microbiology WU Lien-Teh Institute Harbin Medical University Harbin China.

Honey is thought to act against microbes and regulates microbiota balance, and this is mainly attributed to the enzymatic production of hydrogen peroxide, high osmolarity, and nonperoxidase factors, for example, lysozyme and botanical sources of nectar, while the effect of honey's probiotic is recently considered. The study of honey as source of beneficial microbes is understudied. The purpose of this study was to screen for the beneficial microorganisms in honey with antagonistic property against important pathogens and the mechanism of antimicrobial activity and thus play a beneficial role as probiotics. Read More

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September 2020

Dermatological applications of the flavonoid phloretin.

Eur J Pharmacol 2020 Dec 21;889:173593. Epub 2020 Sep 21.

Programa de Pós-Graduação Em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address:

Botanical molecules are known to have the ability to counteract ultraviolet radiation-induced skin damage. The interest in the development of natural compound-based products for the prevention of solar ultraviolet radiation-induced skin photoaging, melasma, and photocarcinogenesis has been increasing. Recently, the flavonoid phloretin has attracted the attention of researchers in the dermatological field for application in cosmetics and therapeutics. Read More

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December 2020

Pentagalloyl glucose from Schinus terebinthifolia inhibits growth of carbapenem-resistant Acinetobacter baumannii.

Sci Rep 2020 09 18;10(1):15340. Epub 2020 Sep 18.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA.

The rise of antibiotic resistance has necessitated a search for new antimicrobials with potent activity against multidrug-resistant gram-negative pathogens, such as carbapenem-resistant Acinetobacter baumannii (CRAB). In this study, a library of botanical extracts generated from plants used to treat infections in traditional medicine was screened for growth inhibition of CRAB. A crude extract of Schinus terebinthifolia leaves exhibited 80% inhibition at 256 µg/mL and underwent bioassay-guided fractionation, leading to the isolation of pentagalloyl glucose (PGG), a bioactive gallotannin. Read More

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September 2020

Quantifying synergy in the bioassay-guided fractionation of natural product extracts.

PLoS One 2020 14;15(8):e0235723. Epub 2020 Aug 14.

Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, United States of America.

Mixtures of drugs often have greater therapeutic value than any of their constituent drugs alone, and such combination therapies are widely used to treat diseases such as cancer, malaria, and viral infections. However, developing useful drug mixtures is challenging due to complex interactions between drugs. Natural substances can be fruitful sources of useful drug mixtures because secondary metabolites produced by living organisms do not often act in isolation in vivo. Read More

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September 2020

A Clerodane Diterpene from Resensitizes Methicillin-Resistant to β-Lactam Antibiotics.

ACS Infect Dis 2020 07 29;6(7):1667-1673. Epub 2020 Jun 29.

Emory University, Department of Dermatology, 615 Michael Street, Whitehead 105L, Atlanta, Georgia 30322, United States.

The rise of antibiotic resistance presents a significant healthcare challenge and precludes the use of many otherwise valuable antibiotics. One potential solution to this problem is the use of antibiotics in combination with resistance-modifying agents, compounds that act synergistically with existing antibiotics to resensitize previously resistant bacteria. In this study, 12(),16ξ-dihydroxycleroda-3,13-dien-15,16-olide, a clerodane diterpene isolated from the medicinal plant , was found to synergize with oxacillin against methicillin-resistant s. Read More

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Clinical effects of date palm (Phoenix dactylifera L.): A systematic review on clinical trials.

Complement Ther Med 2020 Jun 14;51:102429. Epub 2020 May 14.

Department of Persian Medicine, School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Purpose: The aim of present study was to review and categorize the clinical trials investigating the clinical effects of different botanical parts of dates compared with any controls.

Methods: All clinical trials (randomized, pilot, quasi-experimental, cross-over. and non-randomized clinical trials) evaluating the clinical effects of date palm from 2000 until August 2019 in English and Persian languages were included in this systematic review. Read More

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Cytoprotective effects of a proprietary red maple leaf extract and its major polyphenol, ginnalin A, against hydrogen peroxide and methylglyoxal induced oxidative stress in human keratinocytes.

Food Funct 2020 Jun;11(6):5105-5114

Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA. and School of Biotechnology and Health Sciences, Wuyi University, International Healthcare Innovation Institute (Jiangmen), Jiangmen 529020, Guangdong, China.

Phytochemicals from functional foods are common ingredients in dietary supplements and cosmetic products for anti-skin aging effects due to their antioxidant activities. A proprietary red maple (Acer rubrum) leaf extract (Maplifa™) and its major phenolic compound, ginnalin A (GA), have been reported to show antioxidant, anti-melanogenesis, and anti-glycation effects but their protective effects against oxidative stress in human skin cells remain unknown. Herein, we investigated the cytoprotective effects of Maplifa™ and GA against hydrogen peroxide (H2O2) and methylglyoxal (MGO)-induced oxidative stress in human keratinocytes (HaCaT cells). Read More

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Phenolic-enriched maple syrup extract protects human keratinocytes against hydrogen peroxide and methylglyoxal induced cytotoxicity.

Dermatol Ther 2020 05 3;33(3):e13426. Epub 2020 May 3.

Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA.

Reactive carbonyl species including methylglyoxal (MGO) are oxidation metabolites of glucose and precursors of advanced glycation end products (AGEs). They are important mediators of cellular oxidative stress and exacerbate skin complications. Published data supports that certain phenolic compounds can exert cellular protective effects by their antioxidant activity. Read More

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Trichloroacetic acid model to accurately capture the efficacy of treatments for postinflammatory hyperpigmentation.

Arch Dermatol Res 2020 Dec 6;312(10):725-730. Epub 2020 Apr 6.

Department of Dermatology, Henry Ford Hospital, 3031 West Grand Blvd, Detroit, MI, 48202, USA.

Postinflammatory hyperpigmentation (PIH) occurs following cutaneous injury and is common following resolution of acne especially in patients with skin of color. The objective of this study was to further validate a trichloroacetic acid (TCA)-induced PIH model and compare it to acne-induced PIH using topical bakuchiol, a botanical extract that has been shown to have antimicrobial, anti-inflammatory, antioxidant, and antiacne properties. A prospective, non-randomized clinical trial was conducted on subjects with skin phototypes IV-VI with a history of acne-induced PIH. Read More

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December 2020

Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial.

J Cosmet Dermatol 2020 Mar 24;19(3):671-676. Epub 2020 Jan 24.

Master of Science Program in Anti-Aging & Regenerative Medicine, College of Integrative Medicine, Dhurakij Pundit University, Bangkok, Thailand.

Background: Skin aging has many manifestations such as wrinkles, uneven skin tone, and dryness. Both intrinsic and extrinsic factors, especially ultraviolet light-induced oxidative radicals, contribute to the etiology of aging. Human skin requires both water- and lipid-soluble nutrient components, including hydrophilic and lipophilic antioxidants. Read More

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Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

Sci Immunol 2020 01 3;5(43). Epub 2020 Jan 3.

Columbia University Vagelos College of Physicians and Surgeons, Department of Dermatology, New York, NY 10032, USA.

During industrialization, humans have been exposed to increasing numbers of foreign chemicals. Failure of the immune system to tolerate drugs, cosmetics, and other skin products causes allergic contact dermatitis, a T cell-mediated disease with rising prevalence. Models of αβ T cell response emphasize T cell receptor (TCR) contact with peptide-MHC complexes, but this model cannot readily explain activation by most contact dermatitis allergens, which are nonpeptidic molecules. Read More

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January 2020

Skin lightening effect of natural extracts coming from Senegal botanical biodiversity.

Int J Dermatol 2020 Feb 4;59(2):178-183. Epub 2019 Nov 4.

Unité de Technologie et Valorisation Alimentaire, Centre d'Analyses et de Recherche, Université Saint-Joseph, Beirut, Lebanon.

Background: Skin depigmentation is increasingly oriented toward plant extracts because of harmfulness of depigmenting active ingredients used in cosmetics and dermatology. Reconstructed human pigmented epidermis (RHPE) is the closest in vitro model to human skin and offers the possibility to test the global depigmenting effect of a plant extract. These co-cultures of keratinocytes and melanocytes are the most advanced and newest models for testing depigmentation, and until now very few studies have been done with these cultures. Read More

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February 2020

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms.

Microbiome 2019 09 14;7(1):133. Epub 2019 Sep 14.

Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.

Background: The interplay between hosts and their associated microbiome is now recognized as a fundamental basis of the ecology, evolution, and development of both players. These interdependencies inspired a new view of multicellular organisms as "metaorganisms." The goal of the Collaborative Research Center "Origin and Function of Metaorganisms" is to understand why and how microbial communities form long-term associations with hosts from diverse taxonomic groups, ranging from sponges to humans in addition to plants. Read More

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September 2019

Correction: Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells.

Oncotarget 2019 May 21;10(36):3430. Epub 2019 May 21.

Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi, Taiwan.

[This corrects the article DOI: 10.18632/oncotarget.16058. Read More

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Complementary and alternative therapy for pediatric acne: A review of botanical extracts, dietary interventions, and oral supplements.

Pediatr Dermatol 2019 Sep 23;36(5):596-601. Epub 2019 Jun 23.

Division of Dermatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Many supplements and products containing botanical extracts are marketed to patients for the treatment of acne vulgaris. Additionally, increasing attention has been paid to the role of diet in acne vulgaris. Studies on this topic including pediatric patients are limited, with variable efficacy data. Read More

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September 2019

Wound healing with botanicals: A review and future perspectives.

Curr Dermatol Rep 2018 Dec 25;7(4):287-295. Epub 2018 Oct 25.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA, United States.

Purpose Of Review: Botanicals have long played a crucial role in the management of chronic and infected wounds, yet the mechanistic basis of these therapies remains largely poorly understood by modern science.

Recent Findings: Studies have begun to unveil the mechanistic bases of botanical therapies for wound healing, but more work is necessary. Most notably, investigation into the growing conditions, postharvest treatment and pharmacological preparation of these botanicals has demonstrated their importance in terms of the chemical makeup and pharmacological activity of the final product used in pre-clinical and clinical studies. Read More

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December 2018

Extract Protects Mouse Skin from UVB Radiation via Attenuating Collagen Disruption and Inflammation.

Int J Mol Sci 2019 Mar 21;20(6). Epub 2019 Mar 21.

Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Korea.

In recent years, the use of botanical agents to prevent skin damage from solar ultraviolet (UV) irradiation has received considerable attention. is known to exert anti-inflammatory and antioxidant activities. This study investigated photoprotective properties of an extract (OJE) against UVB-induced skin damage in ICR mice. Read More

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