Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models.
- Amelia Muhs,
- James T Lyles,
- Corey P Parlet,
- Kate Nelson,
- Jeffery S Kavanaugh,
- Alexander R Horswill,
- Cassandra L Quave
Sci Rep 2017 Feb 10;7:42275. Epub 2017 Feb 10.
Center for the Study of Human Health, Emory University, 550 Asbury Circle, Candler Library 107E, Atlanta, Georgia, USA.
Widespread antibiotic resistance is on the rise and current therapies are becoming increasingly limited in both scope and efficacy. Methicillin-resistant Staphylococcus aureus (MRSA) represents a major contributor to this trend. Quorum sensing controlled virulence factors include secreted toxins responsible for extensive damage to host tissues and evasion of the immune system response; they are major contributors to morbidity and mortality. Read More