1,046 results match your criteria Bosnian Journal Of Basic Medical Sciences[Journal]


Progress in research on childhood T-cell acute lymphocytic leukemia, Notch1 signaling pathway, and its inhibitors: A review.

Bosn J Basic Med Sci 2020 May 4. Epub 2020 May 4.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China; Department of Pediatrics, Affiliated Hospital of Southwest Medical University, Birth Defects Clinical Medical Research Center of Sichuan Province, Luzhou, China.

Childhood leukemia is a cancer seriously threatening children's life in China. The treatment of T-cell acute lymphocytic leukemia (T-ALL) is extremely difficult due to its early infiltration, poor sensitivity to chemotherapy, and susceptibility to drug resistance. At the same time, the traditional intensive chemotherapy regimens cause great damage to children, so it is highly important to search for the targeted drugs and develop precise individualized treatment of child patients. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4687DOI Listing

A three-dimensional computed tomography study to determine the ideal method for fluoroscopically-guided bone marrow aspiration from the iliac crest.

Bosn J Basic Med Sci 2020 May 11. Epub 2020 May 11.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA; Department of Pain Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Bone marrow aspiration (BMA) through the iliac crest is potentially unsafe due to the vicinity of neurovascular structures in the greater sciatic notch. Our objective was to investigate the safety of a recently described BMA technique, specifically a trajectory from the posterior superior iliac spine (PSIS) to the anterior inferior iliac spine (AIIS). We conducted a chart review of 260 patients, analyzing three-dimensional reconstructed computed tomography images of the pelvis and sacrum to validate that this new approach offers a wide safety margin from the greater sciatic notch. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4744DOI Listing

Clinical management of chronic mercury intoxication secondary to skin lightening products: A proposed algorithm.

Bosn J Basic Med Sci 2020 May 13. Epub 2020 May 13.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.

Mercury is a toxic substance that is commonly used in skin lightening products. Various effects on humans have been observed, which affect both users and non-users. Many cases reported delayed diagnosis and treatment, even after weeks of hospitalization. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4759DOI Listing

Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China.

Bosn J Basic Med Sci 2020 May 5. Epub 2020 May 5.

Department of Clinical Laboratory, Shengli Oil Field Central Hospital, Dongying, China.

Nocardia is a pathogen responsible for a variety of clinical infections. Here, we aimed to investigate the species distribution, clinical manifestations, and antimicrobial susceptibility of Nocardia species in two tertiary general hospitals over 3 years in China. In this retrospective study, a total of 27 Nocardia species were isolated from 27 individuals between January 2017 and December 2019. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4764DOI Listing

Respiratory depression in the post-anesthesia care unit: Mayo Clinic experience.

Bosn J Basic Med Sci 2020 May 13. Epub 2020 May 13.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.

The anesthesia recovery is a complex physiologic process as systems recover from the effects of surgery and anesthesia. Inadequate recovery of respiratory physiology can lead to severe hypoxemia-induced end-organ damage and even death. Emerging evidence suggests that signs of respiratory depression during early anesthesia recovery may portend increased risk for future severe adverse events. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4816DOI Listing

2020 consensus guideline for optimal approach to the diagnosis and treatment of HER2-positive breast cancer in Bosnia and Herzegovina.

Bosn J Basic Med Sci 2020 May 16. Epub 2020 May 16.

University Hospital Foča, Foča, Bosnia and Herzegovina.

The HERe2cure project, which involved a group of breast cancer experts, members of multidisciplinary tumor boards from healthcare institutions in Bosnia and Herzegovina, was initiated with the aim of defining an optimal approach to the diagnosis and treatment of HER2 positive breast cancer. After individual multidisciplinary consensus meetings were held in all oncology centers in Bosnia and Herzegovina, a final consensus meeting was held in order to reconcile the final conclusions discussed in individual meetings. Guidelines were adopted by consensus, based on the presentations and suggestions of experts, which were first discussed in a panel discussion and then agreed electronically between all the authors mentioned. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4846DOI Listing
May 2020
0.413 Impact Factor

Lessons Learned from COVID-19 Pandemic in Italy.

Bosn J Basic Med Sci 2020 May 16. Epub 2020 May 16.

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Italy.

Since the COVID-19 outbreak, Italy has been one of the most affected countries in Europe and the second for number of deaths. In this commentary, we discuss some lessons that we learned as healthcare providers working in a large public hospital during the pandemic, with a special focus on the importance of infection containment and early diagnosis, the role of swab, serological tests, home isolation and individual protection devices,  and the available therapies and management indications to better face a possible new outbreak in the near future. These comments should stimulate a more diffused, efficient and efficacious management of COVID-19 patients, also reducing the number of accesses to hospital emergency departments and the related spread of the infection. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4847DOI Listing

High MTHFR promoter methylation levels in men confer protection against ischemic stroke.

Bosn J Basic Med Sci 2020 Apr 29. Epub 2020 Apr 29.

Nanshan Center for Chronic Disease Control, Shenzhen, China.

The MTHFR gene encodes methylenetetrahydrofolate reductase required for the metabolism of homocysteine (Hcy) - a previously reported independent risk factor for ischemic stroke (IS). In this study, we first aimed to clarify the association between DNA methylation levels in the MTHFR promoter and the risk of IS, followed by the analysis of potential interactions between environmental factors and DNA methylation levels that affect IS risk. We recruited 164 patients with hypertension and IS (case group) and 345 age- and sex-matched patients with hypertension only (control group). Read More

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http://dx.doi.org/10.17305/bjbms.2020.4636DOI Listing

Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 MAPK in human coronary artery endothelial cells.

Bosn J Basic Med Sci 2020 Apr 30. Epub 2020 Apr 30.

Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

C-reactive protein (CRP) is an important predictor of cardiovascular events and plays a role in vascular inflammation and vessel damage. The aim of this study was to investigate the effect of pentameric CRP (pCRP) and monomeric CRP (mCRP) on the production of atherosclerosis-related factors in cultured human coronary artery endothelial cells (HCAECs). HCAECs were treated with pCRP, mCRP, p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580, or transfected with p38 MAPK siRNA. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4711DOI Listing

Chronic maxillary sinusitis of dental origin and oroantral fistula: The results of combined surgical approach in an Italian university hospital.

Bosn J Basic Med Sci 2020 Apr 30. Epub 2020 Apr 30.

Department of Sense Organs, University Sapienza of Rome, Rome, Italy.

Unilateral chronic maxillary sinusitis is a possible complication of odontogenic disease or dental treatment and is mainly due to the development of an oroantral fistula (OAF). The management of chronic maxillary sinusitis of dental origin requires a combined treatment via endoscopic sinus surgery (ESS) and intraoral surgical treatment of the odontogenic source. The aim of this study is to present the results of our university hospital unit in the treatment and follow-up of a case series of 34 patients treated with combined surgical approach for chronic maxillary sinusitis of dental origin due to OAF. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4748DOI Listing

Association of miRNA-145 with the occurrence and prognosis of hydrosalpinx-induced defective endometrial receptivity.

Bosn J Basic Med Sci 2020 Apr 1. Epub 2020 Apr 1.

Department of Reproductive Medicine Center, The First Affiliated Hospital of XinJiang Medical University, Urumqi, XinJiang, China.

MiR-145 is reported to facilitate inflammation and is also associated with unsuccessful embryonic implantation. Whether miR-145 mediates inflammatory response underlying hydrosalpinx-induced defective endometrial receptivity (ER) remains unclear, and this study attempted to clarify this point. Endometrium samples were collected from hydrosalpinx patients (case, n = 243) and patients with tubal patency/obstruction (control, n = 187). Read More

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http://dx.doi.org/10.17305/bjbms.2020.4538DOI Listing

Upper limb principal arteries variations: A cadaveric study with terminological implication.

Bosn J Basic Med Sci 2020 Apr 6. Epub 2020 Apr 6.

Department of Anatomy, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Histology and Embryology, Third Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Health Care Studies, College of Polytechnics Jihlava, Jihlava, Czech Republic.

Although the variability of the upper limb arteries is a clinically important problem, the prevalence varies across the existing studies and the classification is rather complicated, uncoined, and sometimes even unclear for its simple and direct understanding and usage. Multiple case reports appearing in the last years apply incorrect, inappropriate, and sometimes misleading terminology. Here we performed an anatomical cadaveric study of the variability of the arteries of the upper limb, namely the axilla, arm and forearm, in 423 upper limbs (Central European population) embalmed with the classical formaldehyde method. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4643DOI Listing

Uvulopalatopharyngoplasty and barbed reposition pharyngoplasty with and without hyoid suspension for obstructive sleep apnea hypopnea syndrome: A comparison of long-term functional results.

Bosn J Basic Med Sci 2020 04 27. Epub 2020 Apr 27.

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common condition; when conservative approaches are not effective, surgical techniques aimed at reducing the airway obstruction effect are used. This retrospective study aimed at comparing the functional outcomes in patients with OSAHS undergoing uvulopalatopharyngoplasty (UPPP) according to Fairbanks and barbed reposition pharyngoplasty (BRP) according to Mantovani, with or without hyoid suspension (HS). One-hundred twenty-two consecutive OSAHS patients who underwent surgical treatment were included in the study. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4724DOI Listing

Immunohistochemical study of dental pulp cells with 3D collagen type I gel in demineralized dentin tubules in vivo.

Bosn J Basic Med Sci 2020 Mar 27. Epub 2020 Mar 27.

Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.

Dental pulp cells (DPCs) represent good candidates for the regeneration of dental tissue. This study aimed to evaluate the growth and differentiation potential of DPCs cultured inside demineralized dentin tubules in vivo. Six green fluorescent protein (GFP)-transgenic rats (body weight 100 g each) and thirty-two Sprague-Dawley (SD) male rats (body weight 250 g each) were used for DPC collection and dentin tubules preparation and transplantation, respectively. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4614DOI Listing

Endothelial loss during the surgical procedure in saphenous veins harvested by open and endoscopic techniques in coronary artery bypass surgery.

Bosn J Basic Med Sci 2020 Mar 19. Epub 2020 Mar 19.

Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; International Center for Cardiovascular Diseases MC Medicor d.d., Izola, Slovenia.

The patency of the vein graft in coronary artery bypass grafting could be dependent on conventional (vsO) or endoscopic (vsE) harvesting and on the hypoxic damage of endothelial cells. We aimed to evaluate both surgical techniques according to endothelial loss that occurs in the time between harvesting and implantation. Twenty-six saphenous veins were divided into vsO (n = 16) and vsE (n = 10) group. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4656DOI Listing

Laryngeal tuberculosis in renal transplant recipients: A case report and review of the literature.

Bosn J Basic Med Sci 2020 Feb 21. Epub 2020 Feb 21.

Department of Sense Organs, Sapienza University of Rome, Rome, Italy.

Renal allograft recipients are at greater risk of developing tuberculosis than the general population. A woman with a kidney transplant was admitted to the emergency department with high temperature, dysphonia, odynophagia, and asthenia. The final diagnosis was laryngeal tuberculosis. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4448DOI Listing
February 2020

Knockdown of TPT1-AS1 inhibits cell proliferation, cell cycle G1/S transition, and epithelial-mesenchymal transition in gastric cancer.

Bosn J Basic Med Sci 2020 Feb 28. Epub 2020 Feb 28.

Department of General Surgery, The Center Hospital of Ezhou, Ezhou, China.

Long non-coding RNAs are considered to be critical regulators of tumor progression. Tumor protein translationally controlled 1 antisense RNA 1 (TPT1-AS1) was shown to have an oncogenic role in cervical and ovarian cancer. The clinical significance and biological function of TPT1-AS1 in gastric cancer (GC) are not clear. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4470DOI Listing
February 2020
0.413 Impact Factor

Inflammation-related cytokines and their roles in gastroenteropancreatic neuroendocrine neoplasms.

Bosn J Basic Med Sci 2020 Mar 10. Epub 2020 Mar 10.

Department of Pathology and Cytology Ljudevit Jurak, University Hospital Centre Sestre milosrdnice, Zagreb, Croatia; Pathology Department, School of Medicine, University of Zagreb, Zagreb, Croatia.

Proinflammatory counterworks are important at different stages of tumor development, particularly during invasion and metastasis. Immune cells and their signal molecules can influence all stages of tumor progression, as well as therapeutic intervention. Proinflammatory cytokines are known triggers of growth in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Read More

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http://dx.doi.org/10.17305/bjbms.2020.4471DOI Listing

Neural stem cell-conditioned medium ameliorates Aβ25-35-induced damage in SH-SY5Y cells by protecting mitochondrial function.

Bosn J Basic Med Sci 2020 Feb 24. Epub 2020 Feb 24.

Department of Neurology, Qilu Hospital, Shandong University, Jinan, China.

Inhibition of amyloid β (Aβ)-induced mitochondrial damage is considered crucial for reducing the pathological damage in Alzheimer's disease (AD). We evaluated the effect of neural stem cell-conditioned medium (NSC-CDM) on Aβ25-35-induced damage in SH-SY5Y cells. An in vitro model of AD was established by treating SH-SY5Y cells with 40 μM Aβ25-35 for 24 h. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4570DOI Listing
February 2020

Neurological outcome in patients after successful resuscitation in out-of-hospital settings.

Bosn J Basic Med Sci 2020 Feb 24. Epub 2020 Feb 24.

Department of Cardiology and Angiology, University Clinical Centre Maribor, Maribor, Slovenia.

Neurological outcome is an important determinant of death in admitted survivors after out-of-hospital cardiac arrest (OHCA). Studies demonstrated several significant pre-hospital predictors of ischemic brain injury (time to resuscitation, time of resuscitation, and cause of OHCA). Our aim was to evaluate the relationship between post-resuscitation clinical parameters and neurological outcome in OHCA patients, when all recommended therapeutic strategies, including hypothermia, were on board. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4623DOI Listing
February 2020

Asymptomatic neurotoxicity of amyloid β-peptides (Aβ1-42 and Aβ25-35) on mouse embryonic stem cell-derived neural cells.

Bosn J Basic Med Sci 2020 Mar 6. Epub 2020 Mar 6.

Genetics and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Medical Genetics Unit, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

One of the strategies in the establishment of in vitro oxidative stress models for neurodegenerative diseases, such as Alzheimer's disease (AD), is to induce neurotoxicity by amyloid beta (Aβ) peptides in suitable neural cells. Presently, data on the neurotoxicity of Aβ in neural cells differentiated from stem cells are limited. In this study, we attempted to induce oxidative stress in transgenic 46C mouse embryonic stem cell-derived neurons via treatment with Ab peptides (Aβ1-42 and Aβ25-35). Read More

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http://dx.doi.org/10.17305/bjbms.2020.4639DOI Listing

Long non-coding RNA PVT1 regulates the migration of hepatocellular carcinoma HepG2 cells via miR-3619-5p/MKL1 axis.

Bosn J Basic Med Sci 2020 Feb 26. Epub 2020 Feb 26.

Tianjin Institute of Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Third Central Hospital, Tianjin, China; Artificial Cell Engineering Technology Research Center, Tianjin Third Central Hospital, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin, China.

Hepatocellular carcinoma (HCC) is the third most common malignant tumor of the digestive system. Plasma cell tumor heterotopic gene 1 (PVT1) is an intergenic long non-coding RNA that is aberrantly expressed in different cancers. Myocardin related transcription factor A (MKL1) is a transcriptional coactivator of serum response factor that has been shown to promote cancer cell migration and invasion. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4641DOI Listing
February 2020

Can telomere length predict bone health? A review of current evidence.

Bosn J Basic Med Sci 2020 Mar 10. Epub 2020 Mar 10.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Telomeres are repetitive DNA sequences located at the end of chromosomes, which serve as a protective barrier against chromosomal deterioration during cell division. Approximately 50-200 base pairs of nucleotides are lost per cell division and new repetitive nucleotides are added by the enzyme telomerase allowing telomere maintenance. Telomere shortening has been proposed as an indicator for biological ageing, but its relationship with age-related osteoporosis is ambiguous. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4664DOI Listing
March 2020
0.413 Impact Factor

Interventions of a clinical pharmacist in a medical intensive care unit - a retrospective analysis.

Bosn J Basic Med Sci 2020 Feb 10. Epub 2020 Feb 10.

Department of Medical Intensive Care, University Medical Centre Maribor, Maribor, Slovenia.

Several studies demonstrated a significant decrease in prescription errors, adverse drug events, treatment costs and improved patient outcomes, when a clinical pharmacist (CP) was a full member of a multidisciplinary team in the intensive care unit (ICU). Our aim was to evaluate the activities of a CP, included in a 12-bed medical ICU team of a university hospital in the course of several months. We conducted a retrospective analysis of all the CP's interventions from March to November 2017, carried out and documented after reviewing and discussing patients' medical data with the treating ICU physicians. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4612DOI Listing
February 2020

P2X7 receptor as an independent prognostic indicator in gastric cancer.

Bosn J Basic Med Sci 2020 May 1;20(2):188-196. Epub 2020 May 1.

Department of Pathology, Faculty of Medicine, Fırat University, Elazığ, Turkey.

Gastric cancer (GC) is one of the foremost causes of cancer-related death around the world. The P2X7 receptor (P2X7R), a member of the P2X7R subfamily of P2 receptors, is a unique molecule that has been shown to affect tumor growth and progression as well as various inflammatory processes, including proliferation of T lymphocytes, release of cytokines, and production of free oxygen radicals. P2X7R has been established as a prognostic parameter in some cancers, and recently, it has been investigated in the development of new targeted therapies. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202194PMC

Post-operative functional neurological symptom disorder after anesthesia.

Bosn J Basic Med Sci 2020 Feb 12. Epub 2020 Feb 12.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

A rare manifestation during the post-anesthetic period may include the occurrence of functional neurological symptom disorder (FNSD). FNSD is described as neurological symptoms that are not consistently explained by neurological or medical conditions. We report a case series consisting of six patients who underwent a general anesthetic at a tertiary referral hospital and experienced FNSD in the immediate post-anesthetic period. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4646DOI Listing
February 2020

Cisplatin inhibits the proliferation of Saos-2 osteosarcoma cells via the miR-376c/TGFA pathway.

Bosn J Basic Med Sci 2020 Feb 5. Epub 2020 Feb 5.

Department of Orthopedic Disease and Oncology Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.

Transforming growth factor alpha (TGFA) gene is involved in the proliferation and metastasis of various tumors, but its role in cell sensitivity to cisplatin chemotherapy is unclear. In this study, we investigated the mechanism underlying inhibitory effects of cisplatin on growth and proliferation of osteosarcoma cells. Osteosarcoma and normal skeletal muscle tissues were collected from 26 patients by biopsy. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4485DOI Listing
February 2020
0.413 Impact Factor

WD-3 inhibits the proliferation of breast cancer cells by regulating the glycolytic pathway.

Bosn J Basic Med Sci 2020 May 1;20(2):226-235. Epub 2020 May 1.

Department of Oncology, Wuxi Hospital affiliated to Nanjing University of Chinese Medicine, Wuxi, China.

Number 3 Prescription (WD-3) is an herbal remedy used in traditional Chinese medicine that has been shown to improve the outcomes of patients with advanced colon and gastric cancers. This study aimed to investigate the effect of WD-3 on proliferation, glycolysis, and hexokinase 2 expression in breast cancer cells. Four breast cancer cell lines (MDA-MB-231, BT-549, MCF-7, and MCF-7/ADR-RES) were treated with different concentrations of WD-3 compared with blank control (phosphate-buffered saline). Read More

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http://dx.doi.org/10.17305/bjbms.2019.4530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202186PMC

DNA methylation of AHCY may increase the risk of ischemic stroke.

Bosn J Basic Med Sci 2020 Feb 4. Epub 2020 Feb 4.

Department of Neurosurgery, Ningbo First Hospital, Ningbo, China; Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China.

Genetic factors play an important role in the pathogenesis of ischemic stroke. Of these, epigenetic modifications provide a new direction for the study of ischemic stroke pathogenesis. This study aimed to determine the correlation between DNA methylation of the gene encoding S-adenosylhomocysteine hydrolase (AHCY) and the risk of ischemic stroke in 64 ischemic stroke patients and 138 patients with traumatic brain injury (control group). Read More

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http://dx.doi.org/10.17305/bjbms.2020.4535DOI Listing
February 2020

The natural adaptive evolution of cancer: The metastatic ability of cancer cells.

Bosn J Basic Med Sci 2020 Feb 3. Epub 2020 Feb 3.

Clinical Emergency County Hospital "Pius Brinzeu" Timisoara, Center for Gene and Cellular Therapies in the Treatment of Cancer Timisoara - OncoGen, Timisoara, Romania; Department of Functional Sciences "Victor Babes", University of Medicine and Pharmacy Timisoara, Timisoara, Romania.

The ability of cancer to adapt renders it one of the most challenging pathologies of all time. It is the most dreaded pathological entity because of its capacity to metastasize to distant sites in the body, and 90% of all cancer-related deaths recorded to date are attributed to metastasis. Currently, three main theories have been proposed to explain the metastatic pathway of cancer: the epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) hypothesis (1), the cancer stem cell hypothesis (2), and the macrophage-cancer cell fusion hybrid hypothesis (3). Read More

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http://dx.doi.org/10.17305/bjbms.2019.4565DOI Listing
February 2020
0.413 Impact Factor

The key bacterial cell division protein FtsZ as a novel antibacterial drug target.

Bosn J Basic Med Sci 2020 Feb 4. Epub 2020 Feb 4.

Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, China.

The number of multidrug-resistant bacterial strains is currently increasing; thus, the determination of drug targets for the development of novel antimicrobial drugs is urgently needed. FtsZ, the prokaryotic homolog of the eukaryotic tubulin, is a GTP-dependent prokaryotic cytoskeletal protein that is conserved among most bacterial strains. In vitro studies revealed that FtsZ self-assembles into dynamic protofilaments or bundles, and it forms a dynamic Z-ring at the center of the cell, leading to septation and consequent cell division. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4597DOI Listing
February 2020

Significance of chromogranin A and synaptophysin in pancreatic neuroendocrine tumors.

Authors:
Tatsuo Tomita

Bosn J Basic Med Sci 2020 Feb 5. Epub 2020 Feb 5.

Departments of Integrative Biosciences and Pathology, Oregon Health and Science University, Portland, OR, USA.

The two most commonly used immunohistochemical markers for neuroendocrine cells and their tumors are chromogranin A (CgA) and synaptophysin (SPY). CgA is a marker for neuroendocrine secretory granules of four pancreatic hormones and gastrin while SPY is a marker for synaptic vesicles in neuroendocrine cells, which release classic neurotransmitters such as acetylcholine and others. CgA is involved in synthesis and secretion of peptide hormones through exocytosis while function of SPY is elusive. Read More

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http://dx.doi.org/10.17305/bjbms.2020.4632DOI Listing
February 2020

Lysozyme in the treatment of non-infectious sore throat.

Bosn J Basic Med Sci 2020 May 1;20(2):281-282. Epub 2020 May 1.

Scientific Research Unit, Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina.

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http://dx.doi.org/10.17305/bjbms.2019.4619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202184PMC

Diagnostic performance of LI-RADS version 2018 in differentiating hepatocellular carcinoma from other hepatic malignancies in patients with hepatitis B virus infection.

Bosn J Basic Med Sci 2020 Jan 27. Epub 2020 Jan 27.

Liver Imaging Group, Department of Radiology, University of California at San Diego, La Jolla, California, USA.

The diagnostic performance of the Liver Imaging Reporting and Data System (LI-RADS) in differentiating hepatocellular carcinoma (HCC) from other hepatic malignancies has not been investigated in Chinese patients with chronic liver disease from hepatitis B virus (HBV) infection. The aim of this study was to evaluate the accuracy of the LI-RADS version 2018 in differentiating HCC, intrahepatic cholangiocarcinoma (ICCA), and combined HCC-cholangiocarcinoma (cHCC-CCA) in Chinese patients with HBV infection. Seventy consecutive HBV-infected patients with ICCA (n = 48) or cHCC-CCA (n = 22) who underwent contrast-enhanced magnetic resonance imaging (CE-MRI) between 2006 and 2017 were enrolled along with a comparison cohort of 70 patients with HCC and CE-MRI-matched for tumor size (10-19 mm, 20-30 mm, 31-50 mm, and >50 mm). Read More

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http://dx.doi.org/10.17305/bjbms.2019.4576DOI Listing
January 2020

Galectin-1 reduces the severity of dextran sulfate sodium (DSS)-induced ulcerative colitis by suppressing inflammatory and oxidative stress response.

Bosn J Basic Med Sci 2020 Jan 26. Epub 2020 Jan 26.

Institute of Graduate Studies in Sciences, Section of Biology, Istanbul University, Istanbul, Turkey.

Ulcerative colitis is an inflammatory bowel disease that affects a large number of people around the world. Galectin-1 is a β-galactoside-binding lectin with a broad range of biological activities. The effects of galectin-1 on dextran sulfate sodium (DSS)-induced ulcerative colitis in vivo is not clear. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4539DOI Listing
January 2020

MicroRNA-126 enhances the biological function of endothelial progenitor cells under oxidative stress via PI3K/Akt/GSK-3β and ERK1/2 signaling pathways.

Bosn J Basic Med Sci 2020 Jan 30. Epub 2020 Jan 30.

Department of Gerontology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Endothelial progenitor cell (EPC) transplantation is a safe and effective method to treat acute myocardial infarction (AMI). However, oxidative stress leads to the death of a large number of EPCs in the early stage of transplantation, severely weakening the therapeutic effect. Previous studies demonstrated that microRNAs (miRNAs) regulate the biological function of EPCs. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4493DOI Listing
January 2020

Circulating long noncoding RNAs H19 and GAS5 are associated with type 2 diabetes but not with diabetic retinopathy: A preliminary study.

Bosn J Basic Med Sci 2020 Jan 30. Epub 2020 Jan 30.

Department of Clinical Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt; Department of Clinical Laboratory Sciences, Al-Ghad International College for Applied Medical Sciences, Abha, Saudi Arabia.

Recently, a wide range of biological and pathological roles of long noncoding RNAs (lncRNAs) have been discovered. However, the potential role of circulating lncRNAs H19 and GAS5 in type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR) is not clear. Here, we assessed the plasma levels of H19 and GAS5 lncRNAs in T2DM patients with/without DR and evaluated if H19 and GAS5 pre-treatment plasma levels are a predictor of early response to a single aflibercept dose in DR subgroup. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4533DOI Listing
January 2020
0.413 Impact Factor

Overexpression of microRNA-129-5p in glioblastoma inhibits cell proliferation, migration, and colony-forming ability by targeting ZFP36L1.

Bosn J Basic Med Sci 2019 Dec 28. Epub 2019 Dec 28.

Department of Neurosurgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China.

Glioblastoma multiforme (GBM) is a highly invasive cancer with a high recurrence rate. The prognosis of GBM patients remains poor, even after standard surgical resection combined with chemoradiotherapy. Thus, there is an urgent need for new therapeutic targets in GBM. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4503DOI Listing
December 2019

Concordance of PD-L1 expression and CD8+ TIL intensity between NSCLC and synchronous brain metastases.

Bosn J Basic Med Sci 2019 Dec 28. Epub 2019 Dec 28.

Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Programmed death-ligand 1 (PD-L1) is suggested to be a predictive biomarker in non-small-cell lung carcinoma (NSCLC). However, the differential expression of PD-L1 in primary lung tumor vs. synchronous metastases, especially brain metastasis (BM), remains unclear. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4474DOI Listing
December 2019
0.413 Impact Factor

Serum patterns of mir-23a and mir-181b in irritable bowel syndrome and colorectal cancer - A pilot study.

Bosn J Basic Med Sci 2020 May 1;20(2):254-261. Epub 2020 May 1.

Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; MEDFUTURE - Research Center for Advanced Medicine, University of Medicine and Pharmacy Iuliu-Hatieganu, Cluj-Napoca, Romania; Department of Functional Genomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania.

Emerging evidence demonstrates that microRNAs (miRNAs) could serve as reliable biomarkers of inflammation and oncogenesis. The aim of this study was to determine whether miR-23a and miR-181b were suitable as biomarkers of irritable bowel syndrome (IBS) and colorectal cancer (CRC). Forty patients with IBS (29 females, 11 males), 33 with CRC (14 females, 19 males), and 33 healthy controls (17 females, 16 males) were prospectively included. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202192PMC

Androgen effect on connexin expression in the mammalian female reproductive system: a systematic review.

Bosn J Basic Med Sci 2019 Dec 9. Epub 2019 Dec 9.

Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia.

The functions of androgen and connexin in the mammalian female reproductive system are suggested to be related. Previous research has shown that androgen affects connexin expression and localization in the female reproductive system, altering its function. However, no definitive conclusion on their cause-effect relationship has been drawn yet. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4501DOI Listing
December 2019

Expression of the anti-Mullerian hormone, kisspeptin 1, and kisspeptin 1 receptor in polycystic ovary syndrome and controlled ovarian stimulation rat models.

Bosn J Basic Med Sci 2020 Feb 5;20(1):37-43. Epub 2020 Feb 5.

Department of Pathology, Faculty of Veterinary Medicine, University of Firat, Elazig, Turkey.

Polycystic ovary syndrome represents a significant cause of female infertility. The aim of this study was to investigate the expression of anti-Mul-lerian hormone (AMH), kisspeptin 1 (KISS-1), and kisspeptin 1 receptor (KISS1r) in rat models of polycystic ovary syndrome (PCOS) and controlled ovarian stimulation (COS). For this purpose, 28 rats were assigned into four groups. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029206PMC
February 2020

Human brucellosis in pregnancy - an overview.

Bosn J Basic Med Sci 2019 11 27. Epub 2019 Nov 27.

Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Human brucellosis during pregnancy is characterized by significantly less pronounced adverse obstetric outcomes than in animals, but with remarkably more adverse obstetric outcomes when compared to healthy pregnant women. Seroprevalence of brucellosis in pregnancy and cumulative incidence of brucellosis cases per 1000 delivered obstetrical discharges in endemic regions were reported to be 1.5-12. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4499DOI Listing
November 2019
4 Reads

Percutaneous coronary intervention assisted by invasive mechanical ventilation and intra-aortic balloon pump for acute myocardial infarction with cardiogenic shock: Retrospective cohort study and meta-analysis.

Bosn J Basic Med Sci 2019 Nov 27. Epub 2019 Nov 27.

Department of Cardiology, Tianjin Chest Hospital, Jinnan District, Tianjin, China.

The aim of this study was to compare the mortality outcome in patients with acute myocardial infarction and cardiogenic shock who were treated with percutaneous coronary intervention (PCI) assisted by intra-aortic balloon pump (IABP) + invasive mechanical ventilation (IMV) with historical controls. From January 1, 2016 to June 1, 2017, 60 patients were retrospectively enrolled at Tianjin Chest Hospital. Out of these, 88. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4500DOI Listing
November 2019

Vancomycin-releasing cross-linked collagen sponges as wound dressings.

Bosn J Basic Med Sci 2019 Nov 29. Epub 2019 Nov 29.

Department of Clinical Pharmacology and Pharmacy, Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.

The study presents a novel vancomycin-releasing collagen wound dressing derived from Cyprinus carpio collagen type I cross-linked with carbodiimide which retarded the degradation rate and increased the stability of the sponge. Following lyophilization, the dressings were subjected to gamma sterilization. The structure was evaluated via scanning electron microscopy images, micro-computed tomography, and infrared spectrometry. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4496DOI Listing
November 2019

MALAT1 inhibits the Wnt/β-catenin signaling pathway in colon cancer cells and affects cell proliferation and apoptosis.

Bosn J Basic Med Sci 2019 Nov 15. Epub 2019 Nov 15.

Department of Pathology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.

Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is a highly conserved long noncoding RNA, which has been related to various pathological processes, including cancer. The role and mechanism of MALAT1 in colon cancer are not clear. We investigated MALAT1 expression in colon cancer tissues, the effect of MALAT1 on proliferation and apoptosis of SW480 cells, and the signaling pathway involved in the MALAT1 effects. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4408DOI Listing
November 2019
0.413 Impact Factor

Inhibition of miR-9 decreases osteosarcoma cell proliferation.

Bosn J Basic Med Sci 2020 May 1;20(2):218-225. Epub 2020 May 1.

Department of Orthopedics, Central Theater Command General Hospital of the Chinese People's Liberation Army, Wuhan, Hubei, China; Department of Orthopedics, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei, China.

Osteosarcoma (OS) is the most common primary bone tumor that affects adolescents and young adults. Disruption of microRNA (miRNA) regulation is well established in the pathophysiology of different cancers, including OS. Increased expression of miR-9 in OS positively correlates with the tumor size, clinical stage, and distant metastasis. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202196PMC
May 2020
0.413 Impact Factor

Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism.

Bosn J Basic Med Sci 2020 May 1;20(2):248-253. Epub 2020 May 1.

Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey.

Pulmonary embolism (PE) is associated with significant morbidity and mortality. New biological markers are being investigated for estimating the prognosis of PE patients. Since PE is closely associated with inflammatory status, the neutrophil-lymphocyte (NLR), platelet-lymphocyte (PLR), and lymphocyte-monocyte (LMR) ratios were suggested to be useful in predicting patient outcomes. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202190PMC

The effects of mutational profiles on phenotypic presentation of myeloproliferative neoplasm subtypes in Bosnia: 18 year follow-up.

Bosn J Basic Med Sci 2020 May 1;20(2):236-247. Epub 2020 May 1.

Department of Hematology, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

The identification of mutually exclusive somatic mutations shared among myeloproliferative neoplasm (MPN) subtypes has provided a powerful tool for studying disease evolution. Clinical features, gene mutations, and survival over 18 years were analyzed in MPN patients. One hundred thirty-eight MPN patients were subcategorized according to MPN subtypes: essential thrombocythemia (ET, n = 41), polycythemia vera (PV, n = 56), primary myelofibrosis (PMF, n = 10), and MPN unclassified (MPN-U, n = 31). Read More

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http://dx.doi.org/10.17305/bjbms.2019.4391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202189PMC
May 2020
1 Read

Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p/PTEN signaling in diabetic nephropathy.

Bosn J Basic Med Sci 2019 Oct 31. Epub 2019 Oct 31.

Department of Nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Zhejiang, China.

Diabetic nephropathy (DN) is the most common complication of diabetes and is prone to kidney failure. Dihydromyricetin (DHM) has been reported to have a variety of pharmacological activities. This study aims to explore the effect of DHM on DN and the underlying molecular mechanism. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4410DOI Listing
October 2019
1 Read