963 results match your criteria Bosnian Journal Of Basic Medical Sciences[Journal]


Valspodar-modulated chemotherapy in human ovarian cancer cells SK-OV-3 and MDAH-2774.

Bosn J Basic Med Sci 2019 Apr 8. Epub 2019 Apr 8.

Department of Gynecology and Obstetrics, Wroclaw Medical University, Wroclaw, Poland.

Overcoming drug resistance in ovarian cancer is the overarching goal in gynecologic oncology. One way to increase drug cytotoxicity without increasing the drug dose is to simultaneously apply multidrug resistance modulator. Valspodar is the second generation P-glycoprotein 1 modulator capable of reversing multidrug resistance in different cancers. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4073DOI Listing
April 2019
1 Read

Internodal HER2 heterogeneity of axillary lymph node metastases in breast cancer patients.

Bosn J Basic Med Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Clinical Pathology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina.

Determination of human epidermal growth factor receptor 2 (HER2) status is important for adequate treatment of breast cancer (BC) patients. The novel HER2 gene protein assay (GPA) is particularly convenient, as it allows the simultaneous assessment of HER2 protein expression and gene amplification at individual cell level. Here we investigated the frequency of internodal HER2 heterogeneity in axillary lymph node macrometastases of BC patients and compared HER2 status between primary breast tumor and its metastases. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3970DOI Listing
April 2019
1 Read

Clear cell urothelial carcinoma of the urinary bladder - a rare pathological entity. A case report and a systematic review of the literature.

Bosn J Basic Med Sci 2019 Mar 28. Epub 2019 Mar 28.

Department of Morphopathology, The Victor Babes University of Medicine and Pharmacy of Timisoara, Timisoara, Romania.

The most common histological type of urinary bladder cancer is urothelial carcinoma (UC). In contrast, the clear cell variant of urothelial carcinoma (CCUC) is quite a rare neoplasm. In this study, we report a case of an 81-year-old male, presenting with gross hematuria and acute urinary retention, which was subsequently diagnosed with CCUC at our pathology department. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4182DOI Listing
March 2019
1 Read

Targeted immunotherapy with a checkpoint inhibitor in combination with chemotherapy: A new clinical paradigm in the treatment of triple-negative breast cancer.

Bosn J Basic Med Sci 2019 Mar 27. Epub 2019 Mar 27.

College of Medicine, Qatar University, Doha, Qatar.

The treatment of several solid and hematologic malignancies with immune checkpoint inhibitors (against PD-1/PD-L1) has dramatically changed the cancer treatment paradigm. However, no checkpoint inhibitors were previously approved for the treatment of triple-negative breast cancer (TNBC), a difficult-to-treat disease with a high unmet therapeutic need. Based on IMpassion130 clinical trial (NCT02425891), FDA has recently granted an accelerated approval for atezolizumab (TECENTRIQ®), a monoclonal antibody drug targeting PD-L1, plus chemotherapy (Abraxane; nab®-Paclitaxel) for the treatment of adults with PD-L1-positive, unresectable, locally advanced or metastatic TNBC. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4204DOI Listing
March 2019
1 Read

Histological and biochemical effects of Cinnamomum cassia nanoparticles in kidneys of diabetic Sprague-Dawley rats.

Bosn J Basic Med Sci 2019 Mar 22. Epub 2019 Mar 22.

Discipline of Clinical Anatomy, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

This study investigated the antidiabetic activity of Cinnamomum cassia (C. cassia, Cc) silver nanoparticles (CcAgNPS) and effects of C. cassia on the kidneys of rats with induced type 2 diabetes. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3481DOI Listing

Recombinant deoxyribonucleoside kinase from Drosophila melanogaster can improve gemcitabine based combined gene/chemotherapy for targeting cancer cells.

Bosn J Basic Med Sci 2019 Mar 19. Epub 2019 Mar 19.

Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan.

A recombinant deoxyribonucleoside kinase from Drosophila melanogaster with a deletion of the last 20 amino acid residues (named DmdNKΔC20) was hypothesized as a potential therapeutic tool for gene therapy due to its broad substrate specificity and better catalytic efficiency towards nucleosides and nucleoside analogs. This study was designed to evaluate the effect of DmdNKΔC20 for sensitizing human cancer cell lines towards gemcitabine and to further investigate its role in reversal of acquired drug resistance in gemcitabine-resistant cancer cell line. The DmdNKΔC20 gene was delivered to three different cancer cell lines, including breast, colon and liver cancer cells, using lipid-mediated transfection reagent. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4136DOI Listing

Epidemiology and mechanism of drug resistance of Mycoplasma pneumoniae in Beijing, China: A multi-center study.

Bosn J Basic Med Sci 2019 Mar 17. Epub 2019 Mar 17.

Beijing Key Laboratory for Research on Prevention and Treatment of Tropical Diseases, Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Mycoplasma pneumoniae (M. pneumoniae) is one of the most common causes of community-acquired respiratory tract infections (RTIs). We aimed to investigate the prevalence of M. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4053DOI Listing
March 2019
2 Reads

Outcomes and prognostic factors for patients with cervical esophageal cancer undergoing definitive radiotherapy or chemoradiotherapy.

Bosn J Basic Med Sci 2019 Mar 11. Epub 2019 Mar 11.

Department of Radiotherapy, Inner Mongolia Cancer Hospital, The Affiliated People's Hospital of Inner Mongolia Medical University, Hohhot; Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing, China; Research Group for Reproductive Medicine and IVF-Laboratory, Department of Obstetrics and Genecology, University of Cologne, Cologne, Germany.

Cervical esophageal cancer (CEC) is uncommon, accounting for less than 5% of all esophageal cancers. The management of CEC is controversial. This study investigated treatment outcomes and prognostic factors of survival in CEC patients undergoing definitive radiotherapy or concurrent chemoradiotherapy (CCRT). Read More

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http://dx.doi.org/10.17305/bjbms.2019.3873DOI Listing
March 2019
1 Read

Soft tissue grafts for dural reconstruction after meningioma surgery.

Bosn J Basic Med Sci 2019 Mar 11. Epub 2019 Mar 11.

Department of Neurosurgery, University Medical Centre Ljubljana, Ljubljana, Slovenia; Alma Mater Europaea - European Center Maribor (AMEU-ECM), Maribor, Slovenia.

The meninges are involved in various pathologies and are often directly or indirectly severed during surgical procedures, especially the dura mater. This can pose a real challenge for the surgeon, as a proper reconstruction of the meninges is important to prevent complications such as cerebrospinal fluid leak (CSF). A variety of techniques for dural reconstruction have been described, employing natural and artificial materials. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3949DOI Listing

Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer.

Bosn J Basic Med Sci 2019 Feb 26. Epub 2019 Feb 26.

Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.

As important regulators of gene expression long noncoding RNAs (lncRNAs) are implicated in various physiological and pathological processes, including cancer. An oncogenic role of MNX1 antisense RNA 1 (MNX1-AS1) lncRNA has been suggested in cervical cancer and glioblastoma. In this study, we investigated the clinicopathological significance and biological function of MNX1-AS1 in gastric cancer (GC). Read More

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http://dx.doi.org/10.17305/bjbms.2019.3713DOI Listing
February 2019
4 Reads
0.413 Impact Factor

Thymic stromal lymphopoietin levels are increased in patients with celiac disease.

Bosn J Basic Med Sci 2019 Mar 1. Epub 2019 Mar 1.

Department of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey.

Thymic stromal lymphopoietin (TSLP) is a cytokine produced by epithelial cells in the lungs, skin and intestinal mucosa, and is involved in several physiological and pathological processes. In this study, we evaluated serum TSLP levels in patients with celiac disease (CD). The prospective study was conducted at a gastroenterology outpatient clinic between March 2018 and August 2018. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4016DOI Listing
March 2019
3 Reads

Isoflurane exposure in infant rats acutely increases aquaporin 4 and does not cause neurocognitive impairment.

Bosn J Basic Med Sci 2019 Feb 26. Epub 2019 Feb 26.

T.C. Health Ministry, Health Sciences University, Bagcilar Training and Research Hospital, Anesthesiology and Reanimation Clinic, Istanbul, Turkey.

Isoflurane is commonly used in pediatric population, but its mechanism of action in cognition is unclear. Aquaporin 4 (AQP4) regulates water content in blood, brain, and cerebrospinal fluid. Various studies have provided evidence for the role of AQP4 in synaptic plasticity and neurocognition. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4116DOI Listing
February 2019
5 Reads

Enhancement of bone consolidation using high-frequency pulsed electromagnetic fields (HF-PEMFs): An experimental study on rats.

Bosn J Basic Med Sci 2019 Feb 20. Epub 2019 Feb 20.

"Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

In vitro studies showed that high-frequency pulsed electromagnetic fields (HF-PEMFs) increase the activity/expression of early and late osteogenic markers and enhance bone mineralization. The main aim of this study was to investigate the in vivo effects of HF-PEMFs on fracture healing using a rat model. A femur fracture was established by surgery in 20 male Wistar rats. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3854DOI Listing
February 2019

Intervertebral disc tissue engineering: A brief review.

Bosn J Basic Med Sci 2019 Jan 31. Epub 2019 Jan 31.

Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia Laboratory of Inorganic Chemistry, Faculty of Chemistry and Chemical Technology, University of Maribor, Maribor, Slovenia.

Intervertebral disc (IVD) degeneration (IDD) is associated with low back pain and significantly affects the patient's quality of life. Degeneration of the IVD alters disk height and the mechanics of the spine, leading to chronic segmental spinal instability. The pathophysiology of IVD disease is still not well understood. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3778DOI Listing
January 2019

Limb-girdle muscular dystrophy due to GMPPB mutations: A case report and comprehensive literature review.

Bosn J Basic Med Sci 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurology, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan Province, China.

Mutations in the guanosine diphosphate mannose (GDP-mannose) pyrophosphorylase B (GMPPB) gene are rare. To date, 72 cases with GMPPB gene mutations have been reported. Herein, we reported a case of a 29-year-old Chinese male presenting with limb-girdle muscular dystrophy (LGMD) who was found to have two heterozygous GMPPB mutations. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3992DOI Listing
January 2019

Clinical outcomes after intentional replantation of permanent teeth: A systematic review.

Bosn J Basic Med Sci 2019 Jan 17. Epub 2019 Jan 17.

Department of Stomatology, General Hospital of PLA, Beijing, China.

This study aimed to systematically assess the outcomes of intentional replantation (IR) of teeth and to determine the survival rate, success rate, and prognostic factors related to the treatment. A search was conducted for all relevant English language articles published from January 2000 to October 2017. The search terms included "intentional replantation" and "teeth" according to the inclusion criteria. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3937DOI Listing
January 2019
4 Reads

Feasibility and accuracy of a voxel-based neuronavigation system with 3D image rendering in preoperative planning and as a learning tool for young neurosurgeons, exemplified by the anatomical localization of the superior sagittal sinus.

Bosn J Basic Med Sci 2019 Jan 27. Epub 2019 Jan 27.

Department of Neurosurgery, General Hospital Klinikum Bamberg, Bamberg, Germany Department of Neurosurgery, University of Tuebingen Medical Center, Tuebingen, Germany.

It is essential for a neurosurgeon to know individual anatomy and the corresponding anatomical landmarks before starting a surgery. Continuous training, especially of young neurosurgeons, is crucial for understanding complex neuroanatomy. In this study, we used a neuronavigation system with 3D volumetric image rendering to determine the anatomical relationship between the sagittal suture and the superior sagittal sinus (SSS) in patients with intracranial lesions. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3815DOI Listing
January 2019
2 Reads

Adjunct corticosteroid treatment in patients with pneumonia: A precision medicine approach.

Bosn J Basic Med Sci 2019 Jan 12. Epub 2019 Jan 12.

Intensive Care Unit, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3977DOI Listing
January 2019
5 Reads

CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.

Bosn J Basic Med Sci 2019 Jan 14. Epub 2019 Jan 14.

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Hematopoietic stem cell transplantation is commonly used in patients with certain hematological or bone marrow tumors. Total body irradiation combined with chemotherapy is part of the preconditioning protocol that was the most commonly used before hematopoietic stem cell transplantation. However, total body irradiation preconditioning damages other normal cells in bone marrow. Read More

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https://www.bjbms.org/ojs/index.php/bjbms/article/view/3935
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http://dx.doi.org/10.17305/bjbms.2019.3935DOI Listing
January 2019
9 Reads

Neurostructural correlates of strength decrease following total knee arthroplasty: A systematic review of the literature with meta-analysis.

Bosn J Basic Med Sci 2019 Jan 14. Epub 2019 Jan 14.

Science and Research Centre Koper, Institute for Kinesiology Research, Koper, Slovenia.

Recent literature suggests that alterations in both neural and structural components of the neuromuscular system are major determinants of knee extensor muscle weakness after total knee arthroplasty (TKA). Therefore, the goal of this study was to investigate the maximal voluntary strength (MVS), voluntary muscle activation (VMA), and the cross-sectional area (CSA) of the muscle, up to 33 months after the TKA.  We searched relevant scientific databases and literature for outcomes of interest, including quadriceps MVS, VMA, and CSA. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3814DOI Listing
January 2019

Decreased heart rate recovery may predict a high SYNTAX score in patients with stable coronary artery disease.

Bosn J Basic Med Sci 2019 Feb 12;19(1):109-115. Epub 2019 Feb 12.

Department of Cardiology, Katip Celebi University School of Medicine, Izmir, Turkey.

An impaired heart rate recovery (HRR) has been associated with increased risk of cardiovascular events, cardiovascular, and all-cause mortality. However, the diagnostic ability of HRR for the presence and severity of coronary artery disease (CAD) has not been clearly elucidated. Our aim was to investigate the relationship between HRR and the SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score in patients with stable CAD (SCAD). Read More

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http://dx.doi.org/10.17305/bjbms.2019.3725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387669PMC
February 2019
2 Reads

MicroRNAs: Recent insights towards their role in male infertility and reproductive cancers.

Bosn J Basic Med Sci 2019 Feb 12;19(1):31-42. Epub 2019 Feb 12.

Molecular Physiology/Endocrinology Laboratory, Department of Zoology, University of the Punjab, Lahore, Pakistan State Key Laboratory of Stem Cells and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China.

Spermatogenesis is a tightly controlled, multi-step process in which mature spermatozoa are produced. Disruption of regulatory mechanisms in spermatogenesis can lead to male infertility, various diseases of male reproductive system, or even cancer. The spermatogenic impairment in infertile men can be associated with different etiologies, and the exact molecular mechanisms are yet to be determined. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387678PMC
February 2019

Teucrium Polium Plant Extract Provokes Substantial Cytotoxicity at the Early Stage of Embryonic Development.

Bosn J Basic Med Sci 2019 Feb 12;19(1):67-71. Epub 2019 Feb 12.

College of Medicine, Qatar University; Biomedical Research Centre, Qatar University, Doha, Qatar.

The aim of this study is to explore the outcome of Teucrium polium (TP) medicinal plant consumption on the early stage of fetal development. We used the chicken embryo at 3 days of incubation as a model to evaluate the effect of TP plant extract during embryogenesis. In addition, quantitative polymerase chain reaction (qPCR) was applied to explore the expression of six genes related to cell proliferation, apoptosis, sur-vival, angiogenesis, and migration. Read More

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https://www.bjbms.org/ojs/index.php/bjbms/article/view/4052
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http://dx.doi.org/10.17305/bjbms.2018.4052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387674PMC
February 2019
3 Reads

Predictors of acute kidney injury (AKI) in high-risk ST-elevation myocardial infarction (STEMI) patients: A single-center retrospective observational study.

Bosn J Basic Med Sci 2019 Feb 12;19(1):101-108. Epub 2019 Feb 12.

Department of Medical Intensive Care, University Medical Centre Maribor, Maribor, Slovenia.

Acute kidney injury (AKI) is a frequent complication in ST-elevation myocardial infarction (STEMI) patients. Factors other than contrast exposure have been suggested as major contributors to renal dysfunction in patients undergoing primary percutaneous coronary intervention (PPCI). Our aim was to assess the incidence and risk factors of AKI in high-risk STEMI patients, mostly treated by PPCI with implemented measures to prevent contrast-induced AKI. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387676PMC
February 2019

Review of first clinical experiences with a 1.5 Tesla ceiling-mounted moveable intraoperative MRI system in Europe.

Bosn J Basic Med Sci 2019 Feb 12;19(1):24-30. Epub 2019 Feb 12.

Department of Neurosurgery, University of Tuebingen Medical Center, Germany.

High-field intraoperative MRI (iMRI) systems provide excellent imaging quality and are used for resection control and update of image guidance systems in a number of centers. A ceiling-mounted intraoperative MRI system has several advantages compared to a conventional iMRI system. In this article, we report on first clinical experience with using such a state-of-the-art, the 1. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387677PMC
February 2019
4 Reads

Analysis of multidrug-resistant bacteria in 3223 patients with hospital-acquired infections (HAI) from a tertiary general hospital in China.

Bosn J Basic Med Sci 2019 Feb 12;19(1):86-93. Epub 2019 Feb 12.

Department of Medical Affairs, Jining NO.1 People's Hospital, Jining, Shandong Province, China.

The frequency of antimicrobial resistance has increased globally due to misuse and overuse of antibiotics, and multi-drug resistant (MDR) bacteria are now recognized as a major cause of hospital-acquired infections (HAI). Our aim was to investigate the prevalence, distribution, and antimicrobial susceptibility rates of MDR bacteria in patients with HAI from a tertiary hospital in China. We retrospectively evaluated all patients with a confirmed diagnosis of bacterial infection at a tertiary general hospital in Jining, for the period between January 2012 and December 2014. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387671PMC
February 2019
1 Read
0.413 Impact Factor

Vascular endothelial growth factor (VEGF)-related polymorphisms rs10738760 and rs6921438 are not risk factors for proliferative diabetic retinopathy (PDR) in patients with type 2 diabetes mellitus (T2DM).

Bosn J Basic Med Sci 2019 Feb 12;19(1):94-100. Epub 2019 Feb 12.

Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and has been investigated as a candidate gene in a number of conditions, including diabetes and its microvascular complications (e.g., retinopathy and nephropathy). Read More

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http://dx.doi.org/10.17305/bjbms.2018.3519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387670PMC
February 2019
1 Read

How latent viruses cause breast cancer: An explanation based on the microcompetition model.

Bosn J Basic Med Sci 2018 Dec 23. Epub 2018 Dec 23.

The Center for the Biology of Chronic Disease (CBCD), New York, NY, USA.

Most breast cancer cases show a decrease in the concentration of the breast cancer type 1 susceptibility protein (BRCA1). However, only a small portion of these cases have a mutated BRCA1 gene. Although many attempts have been made to identify the reason for the decrease in BRCA1 expression in sporadic, non-heritable breast cancer cases, the cause is still unknown. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3950DOI Listing
December 2018

Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.

Bosn J Basic Med Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Phenibut is a glutamic acid derivative with activity on the γ-aminobutyric acid (GABA) B and A, and β-phenethylamine receptors. It is prescribed in former Communist Bloc countries for anxiolysis and related psychiatric disorders. It can be easily obtained in Western countries, and is thought to have abuse potential. Read More

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http://www.bjbms.org/ojs/index.php/bjbms/article/view/4008
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http://dx.doi.org/10.17305/bjbms.2018.4008DOI Listing
December 2018
14 Reads

Review of the therapeutic neurofeedback method using electroencephalography: EEG Neurofeedback.

Bosn J Basic Med Sci 2018 Nov 20. Epub 2018 Nov 20.

Department of Psychology, Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Koper, Slovenia Graduate School of Neural and Behavioural Sciences, University of Tübingen, Germany.

Electroencephalographic neurofeedback (EEG-NFB) represents a broadly used method that involves a real-time EEG signal measurement, immediate data processing with the extraction of the parameter(s) of interest, and feedback to the individual in a real-time. Using such a feedback loop, the individual may gain better control over the neurophysiological parameters, by inducing changes in brain functioning and, consequently, behavior. It is used as a complementary treatment for a variety of neuropsychological disorders and improvement of cognitive capabilities, creativity or relaxation in healthy subjects. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3785DOI Listing
November 2018

The effect of micro-sized titanium dioxide on WM-266-4 metastatic melanoma cell line.

Bosn J Basic Med Sci 2019 Feb 12;19(1):60-66. Epub 2019 Feb 12.

Dermatovenerology Department, Celje General and Teaching Hospital, Celje, Slovenia Institute of Anatomy, Histology and Embryology, Faculty of Medicine, University of Maribor, Maribor, Slovenia.

Titanium dioxide (TiO2) is widely used as an inorganic UV-filter in cosmetic products; however, it has been classified as possibly carcinogenic to humans. While numerous studies demonstrated cytotoxic and genotoxic effects of nano-sized TiO2 in different cell lines, including human skin cells, studies investigating the effects of micro-TiO2 on human keratinocytes and melanocytes, in healthy and cancer cells, are scarce. Adenosine triphosphate (ATP) binding cassette subfamily B member 5 (ABCB5) is a plasma membrane protein known for its role in the tumorigenicity, progression, and recurrence of melanoma. Read More

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https://www.bjbms.org/ojs/index.php/bjbms/article/view/3674
Publisher Site
http://dx.doi.org/10.17305/bjbms.2018.3674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387668PMC
February 2019
5 Reads

Risk factors for complications and graft failure in kidney transplant patients with sepsis.

Bosn J Basic Med Sci 2018 Sep 16. Epub 2018 Sep 16.

Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

Immunosuppressive therapies decreased the incidence of acute kidney rejection after kidney transplantation, but also increased the risk of infections and sepsis. This study aimed to identify the risk factors associated with complications and/or graft failure in kidney transplant patients with sepsis. A total of 14,658 kidney transplant patients with sepsis, identified in the National Inpatient Sample (NIS) database (data from 2005-2014), were included in the study and classified into three groups: patients without complications or graft failure/dialysis (Group 1), patients with complications only (Group 2), and patients with complications and graft failure/dialysis (Group 3). Read More

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http://dx.doi.org/10.17305/bjbms.2018.3874DOI Listing
September 2018
3 Reads

Prediction of breast cancer metastasis risk using circulating tumor markers: A follow-up study.

Bosn J Basic Med Sci 2018 Sep 17;0(0). Epub 2018 Sep 17.

Radiation Oncology Department, Faculty of Medicine, Uludag University, Bursa, Turkey.

Distant organ tumor dissemination is a major cause of breast cancer-related deaths. In 2010, we analyzed the prognostic importance of the circulating tumor markers (CTM) cytokeratin (CK)19, CK20, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) in relation to the clinical and pathological characteristics of patients with breast cancer (BC). To assess the clinical utility of CK19, CK20 and EGFR in predicting distant metastasis and recurrence in BC, here we report 7-year follow-up results of 77 patients. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3371DOI Listing
September 2018
19 Reads

Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update.

Bosn J Basic Med Sci 2018 Nov 5;18(4):297-304. Epub 2018 Nov 5.

Department of Pancreatic and Biliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252103PMC
November 2018
5 Reads

Induction of epithelial-mesenchymal transition (EMT) and Gli1 expression in head and neck squamous cell carcinoma (HNSCC) spheroid cultures.

Bosn J Basic Med Sci 2018 Nov 7;18(4):336-346. Epub 2018 Nov 7.

Research Institute on Signaling, Developmental Biology and Cancer, Centre A. Lacassagne, Nice, France Genetic, Immunology and Human Pathology Laboratory, Tunis Science Faculty, University El Manar, Tunis, Tunisia.

Tumor microenvironment provides a specialized niche in which a population of stem-like cells is enriched and contributes to cancer progression. Moreover, cancer stem cell (CSC) phenotype has been associated with epithelial-mesenchymal transition (EMT). Here we investigated the effect of tumor microenvironment on the phenotypic characteristics of head and neck cancer cells and expression of CSC markers using a three-dimensional (3D), spheroid, culture system of CAL33 cell line from human tongue squamous cell carcinoma. Read More

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https://www.bjbms.org/ojs/index.php/bjbms/article/view/3243
Publisher Site
http://dx.doi.org/10.17305/bjbms.2018.3243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252098PMC
November 2018
19 Reads

Cannabinoids in cancer treatment: Therapeutic potential and legislation.

Bosn J Basic Med Sci 2019 Feb 12;19(1):14-23. Epub 2019 Feb 12.

Department of Cell Biology, Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia.

The plant Cannabis sativa L. has been used as an herbal remedy for centuries and is the most important source of phytocannabinoids. The endocannabinoid system (ECS) consists of receptors, endogenous ligands (endocannabinoids) and metabolizing enzymes, and plays an important role in different physiological and pathological processes. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387667PMC
February 2019
3 Reads

Dose fall-off during the treatment of thoracic spine metastasis with CyberKnife stereotactic body radiation therapy (SBRT).

Bosn J Basic Med Sci 2018 Aug 2. Epub 2018 Aug 2.

Department of Radiation Oncology, Hainan Branch of Chinese PLA General Hospital, Sanya, China Department of Radiotherapy, Chinese PLA General Hospital, Beijing, China.

CyberKnife stereotactic body radiation therapy (SBRT) is becoming increasingly used for cancer treatment and, to maximize its clinical application, it is important to define the dosimetric characteristics, optimal dose and fractionation regimens. The aim of this study was to evaluate the dose fall-off in two fractionated regimens of CyberKnife SBRT during the treatment of thoracic spinal metastasis. Patients with spinal metastasis involving a vertebra and pedicle were treated with 40 Gy in 5 fractions (n = 4), and patients with spinal metastasis involving only a vertebra received 33 Gy in 3 fractions (n = 4). Read More

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http://dx.doi.org/10.17305/bjbms.2018.3185DOI Listing
August 2018
14 Reads

Downregulation of TSPAN13 by miR-369-3p inhibits cell proliferation in papillary thyroid cancer (PTC).

Bosn J Basic Med Sci 2018 Aug 2. Epub 2018 Aug 2.

Department of Emergency, Jingmen NO.1 People's Hospital, Jingmen, Hubei, China.

Previous studies demonstrated dysregulation of different microRNAs in thyroid cancer. Tetraspanins (TSPANs) are cell surface proteins with critical roles in many cellular processes, and implications in tumor development. Here we investigated the role of miR-369-3p in papillary thyroid cancer (PTC) and its association with TSPAN13. Read More

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http://dx.doi.org/10.17305/bjbms.2018.2865DOI Listing
August 2018
2 Reads

Genetic secrets of long-term glioblastoma survivors.

Authors:
Ivana Jovčevska

Bosn J Basic Med Sci 2018 Aug 14. Epub 2018 Aug 14.

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Glioblastomas account for the majority of primary brain tumors. Although glioblastomas are considered as rare diseases, they represent 60%-70% of all gliomas and in most cases have fatal consequences. Genetic analyses show great heterogeneity both intratumor and intertumor. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3717DOI Listing
August 2018
3 Reads

Upregulation of miR-210 promotes differentiation of mesenchymal stem cells (MSCs) into osteoblasts.

Bosn J Basic Med Sci 2018 Nov 7;18(4):328-335. Epub 2018 Nov 7.

Department of Hematology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Numerous studies indicated that microRNAs are critical in the regulation of cellular differentiation, by controlling the expression of underlying genes. The aim of this study was to investigate the effect of miR-210 upregulation on differentiation of human umbilical cord blood (HUCB)-derived mesenchymal stem cells (MSCs) into osteoblasts. MSCs were isolated from HUCB and confirmed by their adipogenic/osteogenic differentiation and flow cytometric analysis of surface markers. Read More

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http://dx.doi.org/10.17305/bjbms.2018.2633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252095PMC
November 2018
8 Reads

A plea for an extension of the anatomical nomenclature: Organ systems.

Bosn J Basic Med Sci 2019 Feb 12;19(1):1-13. Epub 2019 Feb 12.

Centre of Scientific Information, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

This article is the third part of a series aimed at correcting and extending the anatomical nomenclature. Communication in clinical medicine as well as in medical education is extensively composed of anatomical, histological, and embryological terms. Thus, to avoid any confusion, it is essential to have a concise, exact, perfect and correct anatomical nomenclature. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387675PMC
February 2019
2 Reads

Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis C virus (HCV)-related OLP.

Bosn J Basic Med Sci 2018 Aug 1;18(3):217-223. Epub 2018 Aug 1.

Department of Oral Rehabilitation, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.

Oral lichen planus (OLP) is a chronic inflammatory disease characterized by the occurrence of multiple, symmetrical lesions in the oral cavity. Hepatitis C virus (HCV) infection has been suggested as an etiological factor in OLP. The purpose of this review was to summarize the current literature regarding the treatment of OLP in patients with HCV infection. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087560PMC
August 2018
5 Reads

Effects of epinephrine on heart rate variability and cytokines in a rat sepsis model.

Bosn J Basic Med Sci 2018 Jul 7. Epub 2018 Jul 7.

Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Republic of China Department of Nursing, Yuh-Ing Junior College of Health Care and Management, Kaohsiung City, Taiwan, Republic of China Department of Physical Therapy, Shu-Zen Junior College of Medicine and Management, Kaohsiung City, Taiwan, Republic of China School of Medicine, National Yang-Ming University, Taipei City, Taiwan, Republic of China.

Catecholamines have both anti-inflammatory and vasoactive properties. A decreased cardiac response to catecholamines has been associated with a high risk of death in sepsis and septic shock. The aim of this study was to investigate the effects of epinephrine (EPI) on heart rate variability and autonomic balance, as well as cytokine levels, in a rat sepsis model. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3565DOI Listing
July 2018
2 Reads

Delirium following total joint replacement surgery.

Bosn J Basic Med Sci 2019 Feb 12;19(1):81-85. Epub 2019 Feb 12.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Postoperative delirium (POD) is a common complication associated with increased resource utilization, morbidity and mortality. Our institution screens all postsurgical patients for postoperative delirium. The study aim was to perform an automated interrogation of the electronic health records to estimate the incidence of and identify associated risk factors for POD following total joint arthroplasty (TJA). Read More

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http://dx.doi.org/10.17305/bjbms.2018.3653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387679PMC
February 2019
5 Reads

Simple, reliable, and time-efficient colorimetric method for the assessment of mitochondrial function and toxicity.

Bosn J Basic Med Sci 2018 Nov 7;18(4):367-374. Epub 2018 Nov 7.

Department of Public Health, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Mitochondria are organelles involved in the production of cellular energy, regulation of Ca2+ and redox signaling, and are critical for normal functioning of eukaryotic cells. The dysfunction of mitochondria has been implicated in a wide range of diseases, including metabolic and neurodegenerative disorders and different types of cancers. To better understand the role of mitochondria in healthy and disease states, the development of efficient and reliable tools for the assessment of mitochondrial function is particularly important. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252094PMC
November 2018
3 Reads

Prognostic value of aldehyde dehydrogenase 1 (ALDH1) in invasive breast carcinomas.

Bosn J Basic Med Sci 2018 Nov 7;18(4):313-319. Epub 2018 Nov 7.

Department of Pathology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.

Aldehyde dehydrogenase 1 (ALDH1) has been identified as a marker of cancer stem cells in breast cancer (BC). Recent studies showed that ALDH1 expression is correlated with poor prognostic parameters and worse clinical outcome in BC. We evaluated ALDH1 expression by immunohistochemistry in a series of 217 invasive BCs and investigated the correlation between ALDH1 expression and clinicopathological parameters, molecular subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 [HER2] type, and triple-negative BC [TNBC]), and patient survival. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252102PMC
November 2018
2 Reads

Epidermal growth factor (EGF) promotes bone healing in surgically induced osteonecrosis of the femoral head (ONFH).

Bosn J Basic Med Sci 2018 Nov 7;18(4):352-360. Epub 2018 Nov 7.

Department of Orthopaedics and Traumatology, Agrı State Hospital, Agrı, Turkey.

Angiogenic effects of epidermal growth factor (EGF), a potent mitogen, have been demonstrated previously. Moreover, different in vitro studies showed that EGF affects processes associated with bone healing, such as osteoblast differentiation and bone resorption. The aim of this study was to investigate the effect of combined core decompression (CD) and recombinant human EGF (rhEGF) treatment on early-stage osteonecrosis of the femoral head (ONFH) surgically induced in rats. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252104PMC
November 2018
1 Read

p16/Ki-67 dual staining has a better accuracy than human papillomavirus (HPV) testing in women under 30 years old.

Bosn J Basic Med Sci 2018 Jun 20. Epub 2018 Jun 20.

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Victor Babeş" Timişoara, Timișoara, Romania.

Due to a high rate of transient human papillomavirus (HPV) infection, HPV genotyping has a low specificity for high-grade cervical lesions, especially in young women. p16/Ki-67 dual immunohistochemical staining can also be used for the detection of oncogenic changes in cervical cells. Our aim was to compare the performance of p16/Ki-67 dual staining and HPV genotyping in the detection of high-grade cervical lesions in patients with atypical squamous cells of undetermined significance (ASCUS)/low-grade squamous intraepithelial lesion (LSIL) on Pap smear. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3560DOI Listing
June 2018
6 Reads

Immunohistochemical expression of NEDD9, E-cadherin and γ-catenin and their prognostic significance in pancreatic ductal adenocarcinoma (PDAC).

Bosn J Basic Med Sci 2018 Aug 1;18(3):246-251. Epub 2018 Aug 1.

Department of Pathology and Cytology, Sestre Milosrdnice University Hospital, Zagreb, Croatia.

Extensive research is being conducted to identify novel diagnostic, predictive and prognostic biomarkers for pancreatic ductal adenocarcinoma (PDAC), as only a few markers have been routinely used so far with limited success. Our aim was to assess the expression of neural precursor cell expressed developmentally down-regulated protein 9 (NEDD9), E-cadherin, and γ-catenin in PDAC in relation to clinicopathological parameters and patient survival. We also investigated if there is a correlation of NEDD9 expression with E-cadherin or γ-catenin. Read More

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http://dx.doi.org/10.17305/bjbms.2018.2378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087551PMC
August 2018
2 Reads

Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway.

Bosn J Basic Med Sci 2019 Feb 12;19(1):52-59. Epub 2019 Feb 12.

Breast Surgery, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei, China.

Triple-negative breast cancer (TNBC) is the leading cause of cancer-related death in women. Previous studies indicated that miR-361-5p was downregulated in breast cancer, however, the exact effect of miR-361-5p on TNBC requires further investigation. In the present study, we investigated whether miR-361-5p can act as a tumor suppressor by targeting required for cell differentiation 1 homolog (RQCD1) and inhibiting epidermal growth factor receptor (EGFR)/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway in TNBC. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387672PMC
February 2019