40,476 results match your criteria Borderline Ovarian Cancer


Undiagnosed cardiac deficits in non-small cell carcinoma patients in the candidate population for anti-cachexia clinical trials.

Support Care Cancer 2018 Dec 13. Epub 2018 Dec 13.

Department of Oncology, Division of Palliative Care Medicine, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada.

Purpose: Currently, there is no approved therapy for cancer cachexia. According to European and American regulatory agencies, physical function improvements would be approvable co-primary endpoints of new anti-cachexia medications. As physical functioning is in part dependent on cardiac functioning, we aimed to explore the cardiac status of a group of patients meeting current criteria for inclusion in cachexia clinical trials. Read More

View Article
December 2018

Association between childhood invalidation and borderline personality symptoms: self-construal and conformity as moderating factors.

Borderline Personal Disord Emot Dysregul 2018 7;5:19. Epub 2018 Dec 7.

2Department of Psychological Medicine, National University of Singapore, Singapore, Singapore.

Background: Linehan (1993)'s biosocial model posits that borderline personality disorder (BPD) symptoms develop as a result of a transactional relationship between pre-existing emotional vulnerability and an invalidating childhood environment. Little work, however, has investigated cultural factors that may influence the relationship between childhood invalidation and BPD symptoms. The present study investigated the association between parental invalidation and BPD symptoms, and the role of conformity and self-construal as potential moderators of this association. Read More

View Article
December 2018

A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder.

Transl Psychiatry 2018 Dec 13;8(1):274. Epub 2018 Dec 13.

Department of Psychiatry, University of Oxford, Oxford, UK.

Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective and subjective recall of mood states. However, deriving clinically meaningful information from the complex time series data these technologies present is challenging, and the current implications for patient care are uncertain. Read More

View Article
December 2018

Comparative evaluation of dexmedetomidine and labetalol for attenuating hemodynamic stress responses during laparoscopic cholecystectomy in borderline hypertensive patients.

Rev Esp Anestesiol Reanim 2018 Dec 10. Epub 2018 Dec 10.

Department of Obstetrics and Gynecology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Objective: Various pharmacological agents have been tried to attenuate the pressor response in laparoscopic cholecystectomy patients. We have compared single pre-induction intravenous injection of dexmedetomidine with labetalol for attenuation of haemodynamic stress response.

Methods: A total of 160 patients were considered for this prospective, randomized, double blind clinical study done in a single tertiary care institution. Read More

View Article
December 2018

[Borderline left ventricular ejection fraction is associated with alterations in mitral annular size and function. Results from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study].

Orv Hetil 2018 Dec;159(50):2129-2135

II. Belgyógyászati Klinika és Kardiológiai Központ, Szegedi Tudományegyetem, Általános Orvostudományi Kar, Szent-Györgyi Albert Klinikai Központ Szeged, Semmelweis u. 8., 6725.

Introduction: Morphology and function of the mitral annulus (MA) shows alterations in different valvular (for instance in mitral regurgitation) and non-valvular disorders (for instance in certain cardiomyopathies, cardiac amyloidosis).

Aim: The aim of the present study was to examine the relationship between MA morphologic and functional properties and three-dimensional speckle-tracking echocardiography- (3DSTE) derived left ventricular (LV) ejection fraction (EF) in subjects with normal versus borderline LV-EF.

Method: The present study comprised 146 volunteers (mean age: 32. Read More

View Article
December 2018

Cholesterol Biosensors: A review.

Steroids 2018 Dec 10. Epub 2018 Dec 10.

Department of Biotechnology, Deen Bandhu Chhotu Ram University of Science and Technology, Murthal, Sonipat, India.

Cholesterol is the most important sterol synthesized by most of the human cells majorly in the liver. It is a necessary constituent of cell membranes, it acts as a precursor for the synthesis of steroid hormones, vitamin D, and bile acids. Cholesterol is transported in plasma primarily in the form of low-density lipoproteins (LDL), the principal route for its removal from tissues to the liver is in high-density lipoproteins (HDL), followed by excretion in the bile. Read More

View Article
December 2018

Changes in Attachment Representation in Psychotherapy: Is Reflective Functioning the Crucial Factor?

Z Psychosom Med Psychother 2018 Sep;64(3):222-236

Institute of Psychology University of Innsbruck Austria Institute of Psychology, University of Innsbruck.

Objectives: The study analyzed the interdependence of change in attachment representation and reflective functioning (RF) in psychotherapy.

Methods: RF data from 63 female borderline personality disorder (BPD) patients were analyzed with respect to change of attachment representation (from insecure to secure and from unresolved to resolved) fromthree angles: (1) RF as a moderator variable, (2) RF as an outcome variable, and (3) RF changes over one year of treatment.

Results: Patients who changed to a resolved attachment classification showed higher RF before treatment and at follow-up than patients who remained unresolved (RF = 3. Read More

View Article
September 2018

Early Inflammatory Markers for the Diagnosis of Late-Onset Sepsis in Neonates: The Nosodiag Study.

Front Pediatr 2018 13;6:346. Epub 2018 Nov 13.

Service de Pédiatrie II, Hôpital de Hautepierre, Strasbourg, France.

Early diagnosis is essential to improve the treatment and prognosis of newborn infants with nosocomial bacterial infections. Although cytokines and procalcitonin (PCT) have been evaluated as early inflammatory markers, their diagnostic properties have rarely been compared. This study evaluated and compared the ability of individual inflammatory markers available for clinician (PCT, semi-quantitative determination of IL-8) and of combinations of markers (CRP plus IL-6 or quantitative or semi-quantitative determination of IL-8) to diagnose bacterial nosocomial infections in neonates. Read More

View Article
November 2018

Differential Diagnosis between Duchenne Muscular Dystrophy and Limb Girdle Muscular Dystrophy 2a.

Curr Health Sci J 2015 Oct-Dec;41(4):385-389. Epub 2015 Dec 22.

Pediatrics and Childcare dept., University of Medicine and Pharmacy of Craiova.

Limb Girdle Muscular Dystrophy 2A (LGMD 2A) is the most common form of limb girdle muscular dystrophies caused by mutations in the calpain-3 gene (CAPN-3). The pattern of LGMD 2A can be clinically indistinguishable from that of Duchenne Muscular Dystrophy (DMD). We report a case of a 14-year-old boy which has the initial diagnosed as DMD at 6 years old, based on clinical features and very elevated serum creatine kinase levels. Read More

View Article
December 2015

Adropin and irisin: New biomarkers of cardiac status in patients with end-stage renal disease? A preliminary study.

Adv Clin Exp Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poland.

Background: The new polypeptide hormones adropin and irisin have a broad impact on human metabolism and energy homeostasis. They could be potential biomarkers of cardiac injury. In end-stage renal disease (ESRD), the clinical importance of adropin and irisin is yet to be investigated. Read More

View Article
December 2018

Association between semen parameters and chance of fatherhood - a long-term follow-up study.

Andrology 2018 Dec 7. Epub 2018 Dec 7.

Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, Oslo, Norway.

Background: Evaluation of male fertility includes standard semen analysis; however, there is uncertainty about the value of sperm parameters in predicting fertility.

Objective: To evaluate the association between semen parameters and fatherhood during a long-time period.

Materials And Methods: Semen parameters (total sperm count, concentration, motility, and morphology) and sperm DNA fragmentation Index (DFI) assessed on samples collected from 195 Norwegian men from the general population in 2001/2002 were matched with information about fatherhood until 2015, obtained from the Medical Birth Register. Read More

View Article
December 2018

Diagnostic exome sequencing in 100 consecutive patients with both epilepsy and intellectual disability.

Epilepsia 2018 Dec 7. Epub 2018 Dec 7.

Department of Human Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.

Objective: Epilepsy is highly prevalent among patients with intellectual disability (ID), and seizure control is often difficult. Identification of the underlying etiology in this patient group is important for daily clinical care. We assessed the diagnostic yield of whole exome sequencing (WES). Read More

View Article
December 2018

Significance of F-Fluorodeoxyglucose (FDG) Uptake in Response to Chemoradiotherapy for Pancreatic Cancer.

Ann Surg Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, Kagoshima, Japan.

Background: A metabolic shift to glycolysis is reportedly involved in radioresistance. We examined whether pretreatment F-fluorodeoxyglucose positron emission tomography (FDG-PET), which can detect enhanced glucose uptake, was able to predict the therapeutic response to chemoradiotherapy (CRT) in patients with pancreatic cancer (PC).

Methods: Of 125 PC patients (75 unresectable and 50 borderline resectable), 37 and 26 underwent induction chemotherapy before CRT and surgical resection after CRT, respectively. Read More

View Article
December 2018

[Investigation of antinuclear antibodies in chronic hepatitis B patients].

Mikrobiyol Bul 2018 Oct;52(4):425-430

Adnan Menderes University Faculty of Medicine, Department of Medical Microbiology, Aydın, Turkey.

Antinuclear antibodies (ANA) facilitate the diagnosis and evaluation of patients in many systemic autoimmune conditions. Besides, ANA may also be detected in chronic infectious diseases. Although a number of investigations associated with autoantibody positivity in patients with chronic hepatitis C were reported, autoantibody positivity in patients with chronic hepatitis B remain rarely addressed in the literature. Read More

View Article
October 2018

Recurrence and Familial Inheritance of Intronic Pathogenic Variant Associated With Mild CdLS.

Front Neurol 2018 27;9:967. Epub 2018 Nov 27.

Laboratorio di Ricerche di Citogenetica Medica e Genetica Molecolare, Istituto Auxologico Italiano (IRCCS) Milan, Italy.

Splicing pathogenic variants account for a notable fraction of alterations underlying Cornelia de Lange syndrome but are likely underrepresented, due to overlooking of non-canonical intronic variants by traditional and contemporary sequencing methods. We describe five subjects, belonging to three families, displaying a mild Cornelia de Lange syndrome phenotype who carry the pathogenic variant c.5329-15A>G, affecting the IVS27 branch site, yet reported in a single case. Read More

View Article
November 2018

Dissociative states in borderline personality disorder and their relationships to psychotropic medication.

Neuropsychiatr Dis Treat 2018 23;14:3253-3257. Epub 2018 Nov 23.

Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, 1st Faculty of Medicine, Charles University, Prague, Czech Republic,

Background: According to recent data, dissociation may play an important role in borderline personality disorder (BPD), nevertheless specific influences of psychotropic medication on dissociative symptoms in BPD and their therapeutic indications are largely unknown. The purpose of this study was to assess relationships of dissociative symptoms in BPD patients with levels of psychotropic medication and compare these results with a subgroup of patients with schizophrenia.

Materials And Methods: In this study, we investigated 52 BPD patients and compared the results with a control group of 36 schizophrenia patients. Read More

View Article
November 2018

Association between seizure freedom and default mode network reorganization in patients with unilateral temporal lobe epilepsy.

Epilepsy Behav 2018 Dec 8. Epub 2018 Dec 8.

Epilepsy Center, Medical Center - Faculty of Medicine, University of Freiburg, Germany; Faculty of Medicine, University of Freiburg, Germany; Freiburg Brain Imaging Center, Medical Center - Faculty of Medicine, University of Freiburg, Germany.

Rationale: The spontaneous synchronized activity and intrinsic organization of the Default Mode Network (DMN) has been found to be altered because of epileptic activity of temporal lobe origin. Thus, the aim of the present study was to compare DMN's topological properties in patients with seizure-free (SF) and not seizure-free (NSF) temporal lobe epilepsy (TLE).

Methods: Functional connectivity within the DMN was determined from an 8-minute resting state functional magnetic resonance imaging (fMRI) in 27 patients with TLE (12 SF, 15 NSF) and 15 healthy controls (HC). Read More

View Article
December 2018
1 Read

Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8042-8059

Gynecological Oncology, National Cancer Institute, Aviano, Italy.

Objective: Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. Read More

View Article
November 2018

Genetically Informative Mediation Modeling Applied to Stressors and Personality-Disorder Traits in Etiology of Alcohol Use Disorder.

Behav Genet 2018 Dec 7. Epub 2018 Dec 7.

Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.

A statistical mediation model was developed within a twin design to investigate the etiology of alcohol use disorder (AUD). Unlike conventional statistical mediation models, this biometric mediation model can detect unobserved confounding. Using a sample of 1410 pairs of Norwegian twins, we investigated specific hypotheses that DSM-IV personality-disorder (PD) traits mediate effects of childhood stressful life events (SLEs) on AUD, and that adulthood SLEs mediate effects of PDs on AUD. Read More

View Article
December 2018

Our Rationale of Initiating Neoadjuvant Chemotherapy for Hilar Cholangiocarcinoma: A Proposal of Criteria for "Borderline Resectable" in the Field of Surgery for Hilar Cholangiocarcinoma.

World J Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Background: The concept of "borderline resectable" was recently introduced to the field of surgery for pancreatic cancer, and surgical outcomes for this disease with extremely dismal prognosis have improved since the introduction of this concept. However, no such concept has yet been introduced to the field of surgery for hilar cholangiocarcinoma (HCca).

Aim: To determine a definition and criteria for "borderline resectable" in the field of surgery for HCca. Read More

View Article
December 2018
1 Read

The MAGI2 gene polymorphism rs2160322 is associated with Graves' disease but not with Hashimoto's thyroiditis.

J Endocrinol Invest 2018 Dec 8. Epub 2018 Dec 8.

Department of Emergency, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai, 201508, China.

Purpose: Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune disorders, predominantly including Graves' disease (GD), and Hashimoto's thyroiditis (HT). This study aimed to investigate whether single-nucleotide polymorphisms (SNPs) in MAGI2 and MAGI3 gene contributed to the etiology of AITDs.

Methods: We conducted a case-control study including 1001 patients with AITDs (625 GD, 376 HT) and 846 healthy controls. Read More

View Article
December 2018

The clinical utility of the AUSDRISK tool in assessing change in type 2 diabetes risk in overweight/obese volunteers undertaking a healthy lifestyle intervention.

Prev Med Rep 2019 Mar 30;13:80-84. Epub 2018 Nov 30.

SMART Foods Centre, Faculty of Science Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.

The objective of this study was to assess the clinical utility of the AUSDRISK tool for determining risk of Type 2 diabetes mellitus (T2DM). In this secondary analysis from the HealthTrack study, the AUSDRISK tool was applied to data from overweight/obese volunteers completing a lifestyle intervention trial. Participants were volunteer residents of the Illawarra region recruited in 2014-2015. Read More

View Article

Function Preservation of the Upper Lip after Tumor Resection Using Residual Orbicularis Oris Muscle and Attached Levator Labii Superioris Alaeque Nasi.

Plast Reconstr Surg Glob Open 2018 Oct 4;6(10):e1962. Epub 2018 Oct 4.

Division of Plastic Surgery, Nara Medical University Hospital, Nara, Japan.

We report a case, function preservation of the upper lip after tumor resection was possible using residual orbicularis oris muscle and attached levator labii superioris alaeque nasi. Patient was 67-year-old male with squamous cell carcinoma at the vermilion border. The tumor was resected with an 8-mm margin, leaving the oral mucosa as intact as possible. Read More

View Article
October 2018

Comorbidity of Personality Disorder among Substance Use Disorder Patients: A Narrative Review.

Indian J Psychol Med 2018 Nov-Dec;40(6):517-527

Department of Psychiatry and NDDTC, All India Institute of Medical Sciences, New Delhi, India.

Comorbidity of personality disorders (PDs) and substance use disorders (SUDs) is common in clinical practice. Borderline PD and antisocial PD are particularly found to be associated with SUDs. Our review suggests that the overall prevalence of PD ranges from 10% to 14. Read More

View Article
December 2018

Effect of Internet-based Cognitive Behavioral Humanistic and Interpersonal Training vs. Internet-based General Health Education on Adolescent Depression in Primary Care: A Randomized Clinical Trial.

JAMA Netw Open 2018 Nov;1(7)

Department of General Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

Importance: Although 13-20% of American adolescents experience a depressive episode annually, no scalable primary care model for adolescent depression prevention is currently available.

Objective: To study whether CATCH-IT (Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training) reduces the hazard for depression in at-risk adolescents identified in primary care, as compared to a general health education attention control (HE).

Design: The Promoting AdolescenT Health (PATH) study compares CATCH-IT and HE in a phase 3 single-blind multicenter randomized attention control trial. Read More

View Article
November 2018
3 Reads

Cognitive and Behavioral Profile of Treatment-Naïve Children Aged 6-14 Years with Neurocysticercosis from North India.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):300-303

Department of Pediatrics, Pt B D Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

Background: Neurocysticercosis (NCC) produces a progressive organic brain damage by altering brain function with alterations in memory, difficulties in learning, and behavioral changes. The present study was designed to compare the cognitive and behavioral profile of school-going children aged 6-14 years with newly diagnosed NCC with their age-matched controls.

Materials And Methods: A descriptive cross-sectional study was conducted among children aged 6-14 years with newly (<7 days) diagnosed NCC. Read More

View Article
December 2018

Psychosocial complications in juvenile myoclonic epilepsy.

Epilepsy Behav 2018 Dec 7;90:122-128. Epub 2018 Dec 7.

Department of Neurology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Juvenile myoclonic epilepsy (JME) constitutes about 10% of all epilepsies. Because of executive dysfunction, people with JME may be prone to impulsivity and risk-taking behavior. Our aim was to investigate whether psychosocial issues associated with impulsivity are more prominent in people with JME than in those with other types of genetic generalized epilepsy (GGE). Read More

View Article
December 2018

Differential role of Kruppel like factor 1 (KLF1) gene in red blood cell disorders.

Genomics 2018 Dec 4. Epub 2018 Dec 4.

National Institute of Immunohematology (ICMR), 13th Floor, New Multi-storeyed Building, K.E.M. Hospital Campus, Parel, Mumbai 400012, India. Electronic address:

The master erythroid regulator KLF1,plays a pivotal role during erythroid lineage development by regulating the expression of many erythroid genes. Variations in the KLF1 gene are found to be associated with varied erythroid phenotypes. With the aim of determining the role of KLF1 gene variations in HbF induction and their genotype phenotype relationship, in this study, we screened 370 individuals with different hemoglobinopathy condition. Read More

View Article
December 2018

m-CALP - Yet another way of generating handwritten data through evolution for pattern recognition.

Biosystems 2018 Dec 6. Epub 2018 Dec 6.

Department of Computer Science, FAST-NUCES, Faisal Town, Lahore. Electronic address:

Recently a cellular automata learning and prediction (CALP) model was proposed that used evolution to generate handwritten data for pattern recognition. However, the proposed method by CALP was mechanical and not intuitive, as it did not consider the degree of image deformation that takes place during evolution. The problem with this approach is that it evolved handwritten shapes to a completely different form. Read More

View Article
December 2018

Velopharyngeal insufficiency after maxillary advancement in patients with cleft palate - a survey of risk assessment in the United Kingdom and Ireland.

Br J Oral Maxillofac Surg 2018 Dec 7. Epub 2018 Dec 7.

Northern and Yorkshire Cleft Lip and Palate Service, Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Great George St, Leeds LS1 3EX.

Patients with cleft lip and palate may require orthognathic surgery to correct severe impairments in midfacial growth. Maxillary advancement in this group, however, is linked to deterioration in velopharyngeal function (VPF), and it is not clear how cleft teams assess this risk. We therefore surveyed surgeons from 15 cleft units who provide orthognathic treatment, to gain an understanding of current practice in the UK and Ireland. Read More

View Article
December 2018

The value of MR-detectable ipsilateral ovaries in characterizing the origin and malignancy of an adnexal tumors.

Eur J Radiol 2018 Dec 26;109:62-67. Epub 2018 Oct 26.

Department of Radiology, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai 201508, China. Electronic address:

Objective: To investigate the magnetic resonance (MR) imaging morphological relationship between adnexal tumors and the ipsilateral ovaries to characterize the origin and malignancy of tumors.

Material And Methods: Clinical and MR imaging data of 496 adnexal tumors confirmed by histology (ovary tumors, n = 400, non-ovarian tumors, n = 96; benign tumors, n = 183, borderline tumors, n = 120, and malignant tumors, n = 193) were retrospectively analyzed. The presence and shape of the ipsilateral ovaries within the context of adnexal tumors of different origins, malignancies and configurations were evaluated. Read More

View Article
December 2018
1 Read

Oral cancers: Current status.

Oral Oncol 2018 Dec 24;87:64-69. Epub 2018 Oct 24.

Tata Memorial Hospital, Parel, Mumbai 400012, India.

Oral cancer is a global disease. Despite a well elucidated tumour progression model, these cancers present late. Attempts at early detection by way of adjunctive diagnostic technologies and screening have not lived up to expectations in spite initial promise. Read More

View Article
December 2018

Hydrophobically Driven Morphologically Diverse Self-Assembled Architectures of Deoxycholate and Imidazolium-Based Biamphiphilic Ionic Liquids in Aqueous Medium.

J Phys Chem B 2018 Dec 10. Epub 2018 Dec 10.

Department of Chemistry, UGC-Centre for Advanced Studies-II , Guru Nanak Dev University , Amritsar 143005 , India.

Biamphiphilic ionic liquids (BAILs) having amphiphilic cation and anion are thought to exhibit improved surface activity and colloidal stability to be utilized in different applications. For their effective use, a control over synergetic hydrophobic and electrostatic interactions between oppositely charged ions along with the possibility of tuning of hydrophobicity of the core of aggregates is required. Focusing on this, new BAILs comprising a bile salt anion, deoxycholate, [DC], and 1-alkyl-3-methylimidazolium cations, [C mim] ( n = 2, 4, 6, 8, and 12), were synthesized and characterized for their behavior at air-solution interface as well as in bulk. Read More

View Article
December 2018

Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre.

Breast 2018 Nov 26;43:85-90. Epub 2018 Nov 26.

Department of Surgical Oncology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow Branch, ul. Garncarska 11, 31-115 Cracow, Poland.

Purpose: The primary treatment of choice for patients with phyllodes tumor of the breast (PTB) is surgery. Two major problems regarding the treatment of such patients remain unclear: what is the appropriate surgical margin and what role is played by adjuvant radiotherapy (ART).

Methods: The study provides a retrospective review of all patients with PTB treated between 1952 and 2013 at a single institute. Read More

View Article
November 2018
2 Reads

Widened QRS-T Angle May Be a Measure of Poor Ventricular Stretch During Exercise Among On-duty Firefighters.

J Cardiovasc Nurs 2018 Dec 5. Epub 2018 Dec 5.

Dillon J. Dzikowicz, BS, RN Doctoral (PhD) Student, School of Nursing, University of Rochester, New York. Mary G. Carey, PhD, RN, FAHA, FAAN Associate Professor, School of Nursing, University of Rochester, New York.

Background: The spatial QRS-T angle is a measure of repolarization heterogeneity and may be a predictor of poor ventricular health. It is unknown whether a relationship exists between QRS-T angle and blood pressure (BP) during exercise.

Objective: The purpose of this study was to evaluate the potential relationship between QRS-T angle and BP during exercise, which may be indicative of ventricular stretch. Read More

View Article
December 2018

Difficulties regulating emotions mediates the associations of parental psychological control and emotion invalidation with borderline personality features.

Personal Disord 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology.

Extant research has supported a connection between socialization in childhood and difficulties regulating emotions. The biosocial theory of borderline personality disorder (BPD; Crowell, Beauchaine, & Linehan, 2009; Linehan, 1993) suggests that emotion dysregulation is a core mechanism underlying the extreme behaviors, mood instability, identity disturbance, and relationship instability observed in BPD. The present study investigated the impact of socialization factors related to emotions, parental autonomy support, parental psychological control, and childhood trauma on BPD features in a nonclinical young adult sample (N = 357). Read More

View Article
December 2018

The QTc interval and risk of cardiac events in bulimia nervosa: A long-term follow-up study.

Int J Eat Disord 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.

Objective: An association between bulimia nervosa (BN) and prolonged corrected QT interval (QTc) in the electrocardiogram has been suggested, but results of previous studies are conflicting, and the risk of cardiac events in patients with BN has yet to be investigated.

Method: We estimated mean QTc interval and relative risk of borderline (QTc >440 ms) and prolonged QTc (QTc >460 ms) between adult women with BN (N = 531) and healthy controls (N = 123). In follow-up analyses, we investigated the risk of a primary endpoint (syncope, ventricular tachycardia, and cardiac arrest) and all-cause mortality in patients with BN (N = 702) compared with a population-based cohort derived from the Danish Civil Register (N = 7,020). Read More

View Article
December 2018
2 Reads

ABO Blood Type Has No Impact on Survival in Patients with Epithelial Ovarian Cancer.

J Cancer 2018 21;9(23):4334-4340. Epub 2018 Oct 21.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Evidence for an association between ABO blood type and epithelial ovarian cancer (EOC) survival has so far been limited and conflictive. This study applied a retrospective cohort and included 627 EOC patients diagnosed at Shengjing Hospital of China Medical University between 2011 and 2015. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) between the ABO blood type and progression-free survival (PFS) and overall survival (OS) of EOC patients were assessed using multivariable Cox proportional regression models. Read More

View Article
October 2018
4 Reads

Epstein-Barr Virus-Associated T-Cell Lymphoproliferative Disorder Presenting as Chronic Diarrhea and Intestinal Bleeding: A Case Report.

Front Immunol 2018 16;9:2583. Epub 2018 Nov 16.

Department of Gastroenterology, Bethune First Affiliated Hospital of Jilin University, Changchun, China.

Systemic Epstein-Barr virus-positive T-cell lymphoproliferative childhood disease (EBV+ T-LPD) is extremely rare. Primary acute or chronic active Epstein-Barr virus infection triggers EBV+ T-LPD's onset and the disease involves clonal proliferation of infected T-cells with activated cytotoxic phenotype. The adult-onset EBV+ T-LPD (ASEBV+ T-LPD) is even rarer and needs to be extensively studied. Read More

View Article
November 2018

Change in Emotional and Theory of Mind Processing in Borderline Personality Disorder: A Pilot Study.

J Nerv Ment Dis 2018 Dec;206(12):935-943

Institute of Psychotherapy, and.

Changes in emotional processing (EP) and in theory of mind (TOM) are central across treatment approaches for patients with borderline personality disorder (BPD). Although the assessment of EP relies on the observation of a patient's self-criticism in a two-chair dialogue, an individual's TOM assessments is made based on responses to humorous stimuli based on false beliefs. For this pilot study, we assessed eight patients with BPD before and after a 3-month-long psychiatric treatment, using functional magnetic resonance imaging and behavioral tasks. Read More

View Article
December 2018
1 Read

Do cognitive and neuropsychological functioning deficits coincide with hippocampal alteration during first-psychotic episode?

CNS Spectr 2018 Dec 3:1-7. Epub 2018 Dec 3.

1Bronx-Lebanon Hospital Center,Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York,USA.

Background: Numerous studies shown that structural hippocampal alterations are present in subjects at high risk of developing psychosis or schizophrenia. These findings indicate that in a subset of patients undergoing first-psychosis episode (FPE), hippocampal volume alterations are accompanied by associated cognitive and neuropsychological deficits. The combination of psychological deficits and neuroanatomical alterations, in turn, appears to increase treatment complexity and worsen clinical outcomes. Read More

View Article
December 2018
1 Read

Can we downstage locally advanced pancreatic cancer to resectable? A phase I/II study of induction oxaliplatin and 5-FU chemoradiation.

J Gastrointest Oncol 2018 Oct;9(5):922-935

Department of Surgery, NYU School of Medicine, New York, NY, USA.

Background: Half of patients with pancreatic adenocarcinoma (PC) present with regionally advanced disease. This includes borderline resectable and locally advanced unresectable tumors as defined by current NCCN guidelines for resectability. Chemoradiation (CH-RT) is used in this setting in attempt to control local disease, and possibly downstage to resectable disease. Read More

View Article
October 2018
1 Read

Clinico-Histological Correlation in Hansen's Disease: Three-year Experience at a Newly Established Tertiary Care Center in Central India.

Indian J Dermatol 2018 Nov-Dec;63(6):465-468

Department of Pathology and Lab Medicine, AIIMS, Bhopal, Madhya Pradesh, India.

Background: Hansen's disease is a chronic infectious disease caused by . It is characterized by a wide range of clinical and histological manifestations. Ridley-Jopling criteria are widely used for classifying leprosy. Read More

View Article
December 2018
3 Reads

Assessment of personality disorders in students appearing for medical school entrance examination.

J Pak Med Assoc 2018 Dec;68(12):1763-1768

Dean, Peshawar Medical College, Riphah International University, Islamabad - Pakistan.

Objective: : To investigate personality disorders in medical students appearing for medical school entrance exam.

Methods: The cross-sectional study was conducted at Peshawar Medical College from August 2015 to May 2016, and comprised all the students who undertook medical school entrance examination of the College. They were asked to fill screening questionnaire of international personality disorder examination, based on International Classification of Disease version-10. Read More

View Article
December 2018
1 Read

Quantitative DNA Methylation Analysis of DLGAP2 Gene using Pyrosequencing in Schizophrenia with Tardive Dyskinesia: A Linear Mixed Model Approach.

Sci Rep 2018 Nov 30;8(1):17466. Epub 2018 Nov 30.

Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, 100096, China.

Tardive dyskinesia (TD) is a side effect of antipsychotic medications used to treat schizophrenia (SCZ) and other mental health disorders. No study has previously used pyrosequencing to quantify DNA methylation levels of the DLGAP2 gene; while the quantitative methylation levels among CpG sites within a gene may be correlated. To deal with the correlated measures among three CpG sites within the DLGAP2 gene, this study analyzed DNA methylation levels of the DLGAP2 gene using a linear mixed model (LMM) in a Chinese sample consisting of 35 SCZ patients with TD, 35 SCZ without TD (NTD) and 34 healthy controls (HCs) collected in Beijing, China. Read More

View Article
November 2018
1 Read

Prognostic Significance of Survivin Expression and Combined Analysis with Cancer Stem Cell and Epithelial-Mesenchymal Transition-related Markers in Patients with Rectal Cancer Undergoing Preoperative Chemoradiotherapy.

Anticancer Res 2018 Dec;38(12):6881-6889

Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea.

Aim: To identify the candidate marker predicting treatment response and survival outcome in rectal cancer patients who received preoperative chemoradiotherapy (CRT).

Patients And Methods: Between 2000 and 2015, 159 patients with histologically-confirmed rectal adenocarcinoma underwent preoperative CRT followed by surgery. Among them, 70 patients were enrolled and the expression of survivin, cancer stem cell markers (CD44 and CD133) and epithelial-mesenchymal transition markers (E-cadherin and TWIST1) in pretreatment biopsy specimens were evaluated by immunohistochemistry. Read More

View Article
December 2018
1 Read

Neoadjuvant Chemotherapy Chemoradiotherapy for Patients with Esophageal Squamous Cell Carcinoma.

Anticancer Res 2018 Dec;38(12):6809-6814

Department of Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan

Aim: To confirm the superiority of neoadjuvant chemoradiotherapy (NACRT) over neoadjuvant chemotherapy (NAC) as preoperative therapy for locally advanced esophageal cancer.

Patients And Methods: A total of 298 patients with resectable esophageal cancer were initially enrolled; 62 patients received NAC and 236 patients received NACRT. Propensity score matching was applied to create a study cohort. Read More

View Article
December 2018
1 Read

Cardiometabolic risks in polycystic ovary syndrome: long-term population-based follow-up study.

Fertil Steril 2018 Dec;110(7):1377-1386

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: To evaluate the incidence of hypertension, metabolic syndrome, dyslipidemia, and obesity in comparing women with polycystic ovary syndrome (PCOS) and a control group of healthy women.

Design: Prospective cohort study with the median and interquartile range of 12.9 (10. Read More

View Article
December 2018
1 Read