3,578 results match your criteria Borderline Ovarian Cancer


Clinical Features and Management of Women with Borderline Ovarian Tumors in a Single Center in Brazil.

Rev Bras Ginecol Obstet 2019 Mar 16;41(3):176-182. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Objective:  The aim of the present study was to describe and analyze data of 57 women with borderline ovarian tumors (BOTs) regarding histological characteristics, clinical features and treatment management at the Department of Obstetrics and Gynecology of the Universidade Estadual de Campinas (Unicamp, in the Portuguese acronym).

Methods:  The present retrospective study analyzed data obtained from clinical and histopathological reports of women with BOTs treated in a single cancer center between 2010 and 2018.

Results:  A total of 57 women were included, with a mean age of 48. Read More

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http://dx.doi.org/10.1055/s-0039-1683415DOI Listing
March 2019
1 Read

Distribution of various histopathological types of ovarian tumors: A study of 212 cases from a tertiary care center of Eastern Uttar Pradesh.

J Lab Physicians 2019 Jan-Mar;11(1):75-81

Department of Pathology, Homi Bhabha Cancer Hospital (A unit of Tata Memorial Centre, Mumbai), Varanasi, Uttar Pradesh, India.

Background: Ovarian tumors are one of the leading cancers in females with variable pathological types. This study describes the distribution, clinical and pathological details of various histopathological types of ovarian tumors in a tertiary care hospital in North India.

Materials And Methods: A retrospective data of 3 years were collected for ovarian tumors submitted to the pathology department of a tertiary care hospital. Read More

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http://dx.doi.org/10.4103/JLP.JLP_117_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437827PMC
April 2019
1 Read

A new sonographic marker of borderline ovarian tumors: the microcystic pattern of papillary projections and solid components.

Ultrasound Obstet Gynecol 2019 Apr 4. Epub 2019 Apr 4.

Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, New York University School of Medicine, Langone Health.

Objective: Accurate diagnosis of borderline ovarian tumors (BOTs) is important to ensure timely and appropriate management, especially in women desiring to preserve fertility. Transvaginal ultrasound (TVUS) is considered the best modality to diagnose adnexal tumors. Sonographic features of BOTs described in the literature include septa, solid components, mural nodules (papillae) and blood vessels within these structures. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20283
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http://dx.doi.org/10.1002/uog.20283DOI Listing
April 2019
7 Reads
3.853 Impact Factor

Tubal Origin of "Ovarian" Low-Grade Serous Carcinoma: A Gene Expression Profile Study.

J Oncol 2019 5;2019:8659754. Epub 2019 Mar 5.

Department of Obstetrics and Gynecology, Henan Provincial People's Hospital, Zhengzhou, China.

Objective: Ovarian low-grade serous carcinomas are thought to evolve in a stepwise fashion from ovarian epithelial inclusions, serous cystadenomas, and serous borderline tumors. Our previous study with clinicopathological approach showed that the majority ovarian epithelial inclusions are derived from the fallopian tubal epithelia rather than from ovarian surface epithelia. This study was designed to gain further insight into the cellular origin of ovarian low-grade serous carcinomas by differential gene expression profiling studies. Read More

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https://www.hindawi.com/journals/jo/2019/8659754/
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http://dx.doi.org/10.1155/2019/8659754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425354PMC
March 2019
11 Reads

Utero-ovarian preservation and overall survival of young women with early-stage borderline ovarian tumors.

Arch Gynecol Obstet 2019 Mar 28. Epub 2019 Mar 28.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Los Angeles County Medical Center, University of Southern California, 2020 Zonal Avenue, IRD520, Los Angeles, CA, 90033, USA.

Purpose: To examine survival of women who had uterine and ovarian preservation during surgical treatment for early-stage borderline ovarian tumors (BOTs).

Methods: The Surveillance, Epidemiology, and End Results Program was used to identify women aged < 50 years with stage I BOTs who underwent ovarian conservation at surgical treatment between 1988 and 2003. Survival outcomes were examined based on the use of concurrent hysterectomy at surgery. Read More

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http://dx.doi.org/10.1007/s00404-019-05121-zDOI Listing
March 2019
1 Read

Influence of p53 Isoform Expression on Survival in High-Grade Serous Ovarian Cancers.

Sci Rep 2019 Mar 27;9(1):5244. Epub 2019 Mar 27.

Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, 5020, Bergen, Norway.

High-grade serous ovarian carcinoma (HGSOC) is characterised by alterations in the p53 pathway. The expression levels of p53 isoforms have been shown to be associated with patient survival in several cancers. This study examined the predictive and prognostic effects of the expression levels of TP53 pre-mRNA splicing isoforms and TP53 mutations in tumour tissues in 40 chemotherapy responders and 29 non-responders with HGSOC. Read More

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http://dx.doi.org/10.1038/s41598-019-41706-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437169PMC
March 2019
2 Reads

Peritonectomy and hyperthermic intraperitoneal chemotherapy for advanced epithelial ovarian cancer: What gynaecological oncologists really think.

Authors:
Rhonda Farrell

Aust N Z J Obstet Gynaecol 2019 Mar 27. Epub 2019 Mar 27.

Prince of Wales Private Hospital, Sydney, New South Wales, Australia.

Background: Peritonectomy and hyperthermic intraperitoneal chemotherapy (HIPEC) is used in specialised units outside of gynaecological cancer centres in Australia and New Zealand to treat advanced epithelial ovarian cancer (AEOC). There is significant equipoise toward this treatment by gynaecological oncologists (CGOs).

Aims: To determine the attitudes and preferences of CGOs toward peritonectomy and HIPEC for the treatment of AEOC. Read More

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http://dx.doi.org/10.1111/ajo.12972DOI Listing
March 2019
1 Read

Metalloproteinases at the surface of small extrcellular vesicles in advanced ovarian cancer: Relationships with ascites volume and peritoneal canceromatosis index.

Clin Chim Acta 2019 Mar 20;494:116-122. Epub 2019 Mar 20.

Cancer Research Institute, Тomsk National Research Medical Center, Russian Academy of Science, Tomsk, Russia.

Metalloproteinases and their extracellular matrix metalloproteinase inducer (EMMPRIN) play an essential role in the regulation of signaling from growth factors receptors and adhesion molecules, cell motility and extracellular matrix degradation. The aim of the study was to evaluate the relationship between the levels of small extracellular vesicles (sEVs) metalloproteinases, such as ADAM10, ADAM17, MMP2, MMP9 and EMMPRIN and ascites volume and peritoneal canceromatosis index in advanced ovarian cancer patients (OCPs). The subpopulations of metalloproteinases at the surface of sEVs of borderline ovarian tumor patients (BOTPs) (n = 20, 36. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193172
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http://dx.doi.org/10.1016/j.cca.2019.03.1621DOI Listing
March 2019
5 Reads

Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.

Gynecol Oncol 2019 Mar 19. Epub 2019 Mar 19.

Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Objective: Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC) have focused largely on populations of European ancestry. We aimed to identify common germline variants associated with EOC risk in Asian women.

Methods: Genotyping was performed as part of the OncoArray project. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.023DOI Listing
March 2019
4 Reads
3.774 Impact Factor

Preoperative colonoscopy in patients with a supposed primary ovarian cancer.

Medicine (Baltimore) 2019 Mar;98(12):e14929

Medical Faculty, University of Rzeszow.

The final diagnosis of ovarian cancer is based on surgery and pathological verification. Therefore patients who are presented to surgery may be described only as supposed ovarian cancer. According to the literature the diagnosis of ovarian cancer is confirmed only in 2/3 of them. Read More

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http://Insights.ovid.com/crossref?an=00005792-201903220-0004
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http://dx.doi.org/10.1097/MD.0000000000014929DOI Listing
March 2019
5 Reads

Recurrent serous borderline ovarian tumour.

Arch Gynecol Obstet 2019 Mar 20. Epub 2019 Mar 20.

West London Gynaecological Cancer Centre, Hammersmith Hospital, Imperial College NHS Trust, Du Cane Road, London, W12 0HS, UK.

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http://dx.doi.org/10.1007/s00404-019-05120-0DOI Listing
March 2019
1 Read

Sexually transmitted infections and risk of epithelial ovarian cancer: results from the Nurses' Health Studies.

Br J Cancer 2019 Apr 21;120(8):855-860. Epub 2019 Mar 21.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Background: Sexually transmitted infections (STIs) are associated with pelvic inflammatory disease and tubal pathologies. Given the tubal origin of a proportion of ovarian cancers, STIs may be relevant in their aetiology.

Methods: Antibodies indicating past infection with Chlamydia trachomatis, Mycoplasma genitalium, herpes simplex virus type 2, and against human papillomavirus oncogenes (L1 and E6+E7 oncoproteins of types 16, 18, 45) were measured in prediagnosis plasma samples in a nested case-control study in the Nurses' Health Studies (n = 337 cases 1:1 matched to controls). Read More

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http://dx.doi.org/10.1038/s41416-019-0422-9DOI Listing
April 2019
2 Reads

Expression of zinc finger transcription factors (ZNF143 and ZNF281) in serous borderline ovarian tumors and low-grade ovarian cancers.

J Ovarian Res 2019 Mar 18;12(1):23. Epub 2019 Mar 18.

Department of Obstetrics and Gynecology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, ul. Ujejskiego 75, 85-168, Bydgoszcz, Poland.

Low-grade ovarian cancers represent up to 8% of all epithelial ovarian carcinomas (EOCs). Recent studies demonstrated that epithelial-mesenchymal transition (EMT) is crucial for the progression of EOCs. EMT plays a key role in cancer invasion, metastasis formation and chemotherapy resistance. Read More

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http://dx.doi.org/10.1186/s13048-019-0501-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423742PMC
March 2019
1 Read

[How I do… an adnexectomy for a large ovarian mass with suspicion of borderline ovarian tumor by laparoscopy].

Gynecol Obstet Fertil Senol 2019 Mar 12. Epub 2019 Mar 12.

Service de chirurgie et cancérologie gynécologique et mammaire, Pitié-Salpêtrière, Sorbonne université, AP-HP, 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.gofs.2019.03.004DOI Listing
March 2019
1 Read

The cell tube block technique and an immunohistochemistry panel including Wilms tumor 1 to assist in diagnosing cavitary effusions in dogs and cats.

Vet Clin Pathol 2019 Mar 13;48(1):50-60. Epub 2019 Mar 13.

DIMEVET Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milan, Italy.

Background: Cell blocks and immunohistochemistry (IHC) are increasingly recognized as being complementary tools for cytologic diagnostics, especially for neoplastic diseases.

Objectives: The study aimed to evaluate the utility of cell tube block (CTB) IHC for refining the diagnosis of effusions in dogs and cats.

Methods: Cavitary effusions (n = 25) from dogs and cats classified by cytology as reactive, neoplastic, borderline (suspicious of neoplasia), and chylous were studied. Read More

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http://dx.doi.org/10.1111/vcp.12709DOI Listing
March 2019
1 Read

Pulmonary thromboembolism secondary to pelvic thrombosis related to giant ovarian tumor.

Autops Case Rep 2019 Jan-Mar;9(1):e2018061. Epub 2019 Jan 14.

Università degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, Sezione di Medicina Legale e delle Assicurazioni. Milano, Italy.

Pulmonary thromboembolism (PTE) is one of the major complications in oncologic patients. The incidence of PTE in these cases is 4 to 7 times higher than in non-oncologic patients. Ovarian tumors, specifically those of large sizes, may impair the blood flow through the pelvic veins as tumor pressure over the pelvic vessels increases the incidence of thrombosis. Read More

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http://www.autopsyandcasereports.org/article/doi/10.4322/acr
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http://dx.doi.org/10.4322/acr.2018.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394364PMC
January 2019
9 Reads

Intraoperative frozen section analysis of ovarian tumors: a 11-year review of accuracy with clinicopathological correlation in a Hong Kong Regional hospital.

Int J Gynecol Cancer 2019 Jan 4. Epub 2019 Jan 4.

Clinical Research Centre, Princess Margaret Hospital, Hong Kong, Hong Kong.

Objective: Intra-operative frozen section (IFS) can provide an instinct guide for treatment of ovarian tumors intra-operatively, though limitations exist. This study intended to evaluate the diagnostic performance of IFS and possible clinicopathological factors influencing the diagnostic accuracy of IFS.

Methods: A retrospective review of IFS of ovarian lesions from 2006 to 2016 was done. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000048DOI Listing
January 2019
3 Reads

Oncologic and fertility impact of surgical approach for borderline ovarian tumours treated with fertility sparing surgery.

Eur J Cancer 2019 Apr 28;111:61-68. Epub 2019 Feb 28.

Department of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy; Clinic of Obstetrics and Gynecology, San Gerardo Hospital, Via Pergolesi 33, 20900, Monza, Italy.

Background: Even if borderline ovarian tumours (BOTs) in young women treated with fertility-sparing treatment (FST) have an excellent outcome, the type of surgery might affect relapse and fertility. We investigated the effect of surgical approach (open surgery vs. laparoscopy) and type of surgery (salpingo-oophorectomy [SO] vs. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.021DOI Listing
April 2019
2 Reads

Evaluation of histo-pathogical patterns of ovarian masses in relation to age in Rawalpindi-Islamabad region - Lab Research.

J Pak Med Assoc 2019 Feb;69(2):285-289

Army Medical College, National University of Medical Sciences, Rawalpindi.

Objective: To evaluate the histopathological patterns of ovarian tumours in relation to age in Rawalpindi-Islamabad region of Pakistan.

Methods: The retrospective study was conducted at the Army Medical College, Rawalpindi, Pakistan, and comprised data related to ovarian tumour cases from 2013 to 2017). Tumour type, tumour subtype, tumour size, cancer staging and age of patients were noted from the medical records. Read More

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February 2019

Mucinous borderline ovarian tumor versus invasive well-differentiated mucinous ovarian cancer: Difference in characteristics and outcomes.

Gynecol Oncol 2019 Feb 20. Epub 2019 Feb 20.

Department of Gynecologic Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Objective: Mucinous borderline ovarian tumor (mucinous-BOT) and invasive well-differentiated mucinous ovarian cancer (mucinous-OC) are often histopathologically misclassified. The objective of this study was to examine differences in clinico-pathological characteristics and outcomes of these two entities.

Methods: This is a retrospective population-based study examining the Surveillance, Epidemiology, and End Results Program from 1988 to 2000. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.003DOI Listing
February 2019
1 Read

Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls.

Authors:
Natalia Buza

Arch Pathol Lab Med 2019 Jan;143(1):47-64

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Context.—: Epithelial tumors of the ovary are one of the most frequently encountered gynecologic specimens in the frozen section laboratory. The preoperative diagnostic workup of an ovarian mass is typically limited to imaging studies and serum markers, both of which suffer from low sensitivity and specificity. Read More

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http://dx.doi.org/10.5858/arpa.2018-0289-RADOI Listing
January 2019

EGFR Immunoexpression in Malignant Serous and Mucinous Ovarian Tumors.

Curr Health Sci J 2018 Apr-Jun;44(2):129-134. Epub 2018 Mar 27.

Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.

The epithelial growth factor receptor (EGFR) is involved in various stages of cancer growth such as tumor initiation, angiogenesis and metastasis, being an attractive target for oncogenic therapy. The present study aims to evaluate the EGFR expression in 54 cases of serous and mucinous ovarian borderline tumors and carcinomas. EGFR expression was present in more than half of the investigated tumors, more frequently in carcinomas than in borderline tumors, especially in the serous type. Read More

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http://dx.doi.org/10.12865/CHSJ.44.02.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320459PMC

Risk of complications in patients with conservatively managed ovarian tumours (IOTA5): a 2-year interim analysis of a multicentre, prospective, cohort study.

Lancet Oncol 2019 Mar 5;20(3):448-458. Epub 2019 Feb 5.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Background: Ovarian tumours are usually surgically removed because of the presumed risk of complications. Few large prospective studies on long-term follow-up of adnexal masses exist. We aimed to estimate the cumulative incidence of cyst complications and malignancy during the first 2 years of follow-up after adnexal masses have been classified as benign by use of ultrasonography. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183083
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http://dx.doi.org/10.1016/S1470-2045(18)30837-4DOI Listing
March 2019
4 Reads

TMEFF1 overexpression and its mechanism for tumor promotion in ovarian cancer.

Cancer Manag Res 2019 17;11:839-855. Epub 2019 Jan 17.

Department of Obstetrics and Gynaecology, Shengjing Hospital Affiliated to China Medical University, Liaoning, China,

Background: Transmembrane protein with epidermal growth factor-like and two follistatin-like domains 1 (TMEFF1) has an anticarcinogenic effect in brain tumors. However, little is known about the role of TMEFF1 in epithelial ovarian cancer (EOC).

Materials And Methods: TMEFF1 expression in EOC was detected by immunohistochemistry; its relationship with clinical pathological parameters and its influence on prognosis were analyzed. Read More

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https://www.dovepress.com/tmeff1-overexpression-and-its-mech
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http://dx.doi.org/10.2147/CMAR.S186080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340504PMC
January 2019
12 Reads

Tumors of low malignant potential a single institution experience.

Int J Surg Case Rep 2019 19;55:41-46. Epub 2019 Jan 19.

Surgical Oncology Department, Institute Salah Azaiez de cancer, Tunis, Tunisia; Faculté de medicine, Tunis El Manar, Tunisia. Electronic address:

Background: The tumors of low malignant potential are an independent group of the ovarian epithelial tumors. They represents 10-20% of all ovarian epithelial tumors. Our aim through this study to determine how to treat this disease in the most suitable way. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351433PMC
January 2019
4 Reads

Protease Cargo in Circulating Exosomes of Breast Cancer and Ovarian Cancer Patients

Asian Pac J Cancer Prev 2019 Jan 25;20(1):255-262. Epub 2019 Jan 25.

Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.

Background: As is known, exosomes play an important role in promoting progression of cancers by increasing its invasive potential. The aim of this study was to evaluate the levels of tetraspanine-associated (ADAM-10) and tetraspanine-nonassociated proteases (20S proteasomes) in exosomes from culture medium, plasma exosomes of patients with breast tumors and plasma and ascites of ovarian tumor patients. Methods: MCF-7 and SVO-3 culture mediums and blood samples from healthy females (n = 30, HFs), patients with diffuse dyshormonal dysplasia of the breast (n=28, BBTPs), breast cancer patients (n=32, BCPs), borderline ovarian tumor patients (n=20, BOTPs) and blood and ascites samples ovarian cancer patients (n=35, OCPs) were included in the study. Read More

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http://journal.waocp.org/article_81713.html
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http://dx.doi.org/10.31557/APJCP.2019.20.1.255DOI Listing
January 2019
7 Reads

Assessing the landscape of ovarian serous borderline tumors.

Int J Gynecol Cancer 2019 Mar 18;29(3):572-578. Epub 2019 Jan 18.

Pathology Department, "IASO" Women's Hospital, Maroussi, Greece.

Aim: To compare distinct clinicopathological features between atypical proliferative serous tumors and non-invasive low-grade ovarian serous carcinomas.

Methods: Our study group comprised 203 cases of serous borderline tumors sub-classified as atypical proliferative serous tumors or as non-invasive low-grade serous carcinomas. All pathological features related to borderline tumors were re-evaluated by two gynecological pathologists. Read More

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http://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000086
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http://dx.doi.org/10.1136/ijgc-2018-000086DOI Listing
March 2019
25 Reads

Ovarian mucinous cystic tumor associated with sarcomatous mural nodule and benign Brenner tumor: A case report and literature review.

Medicine (Baltimore) 2019 Jan;98(3):e14066

Department of Obstetrics and Gynaecology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, P.R. China.

Rationale: Ovarian mucinous tumor with malignant mural nodule is exceedingly rare. We report a case of ovarian mucinous cystic tumor associated with sarcomatous mural nodule and benign Brenner tumor and accompanied by nodular histiocytic aggregates in the greater omentum.

Patient Concerns: A 60-year-old postmenopausal woman was presented with a history of one month of lower abdominal discomfort, abdominal distension, nausea, and vomiting. Read More

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http://dx.doi.org/10.1097/MD.0000000000014066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370064PMC
January 2019
14 Reads
5.723 Impact Factor

Rare metastatic patterns after malignant transformation of serous borderline tumor of the ovary.

J Surg Oncol 2019 May 15;119(6):814-816. Epub 2019 Jan 15.

Division of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.

Serous borderline tumors are rare, benign ovarian neoplasms that may recur and undergo malignant transformation to low-grade serous carcinomas (LGSCs). In this report, a 50-year-old female with a remote history of a serous borderline ovarian tumor experienced a recurrence of LGSC, presenting as a large solitary subcutaneous mass anterior to the sternum after a 33-year disease-free interval. The described case highlights the unpredictable nature of this disease and the importance of implementing lifelong surveillance strategies. Read More

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http://dx.doi.org/10.1002/jso.25380DOI Listing
May 2019
3 Reads

High-grade serous ovarian carcinoma with mucinous differentiation: report of a rare and unique case suggesting transition from the "SET" feature of high-grade serous carcinoma to the "STEM" feature.

Diagn Pathol 2019 Jan 12;14(1). Epub 2019 Jan 12.

Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.

Background: High-grade serous carcinoma, a representative high-grade ovarian carcinoma, is believed to be closely associated with a TP53 mutation. Recently, this category of ovarian carcinoma has gained increasing attention owing to the recognition of morphological varieties of TP53-mutated high-grade ovarian carcinoma. Herein, we report the case of a patient with high-grade serous carcinoma with mucinous differentiation. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13000-019-0781-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330567PMC
January 2019
12 Reads

Diagnostic Accuracy of the Risk of Ovarian Malignancy Algorithm in Clinical Practice at a Single Hospital in Korea.

Ann Lab Med 2019 05;39(3):252-262

Department of Obstetrics and Gynecology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: The risk of ovarian malignancy algorithm (ROMA) is used for assessing ovarian cancer risk in women with a pelvic mass. Its diagnostic accuracy is variable. We investigated whether the clinically acceptable minimal sensitivity of >80. Read More

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http://dx.doi.org/10.3343/alm.2019.39.3.252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340842PMC
May 2019
4 Reads

Borderline tumours of the ovary: Common practice in the Netherlands.

Gynecol Oncol Rep 2019 Feb 10;27:25-30. Epub 2018 Dec 10.

Isala Hospital, Department of Obstetrics and Gynaecology, Zwolle, the Netherlands.

Objectives: Discordance between frozen section diagnosis and the definite histopathological diagnosis and the fact that the frozen section result is not always unambiguous, may contribute to differences in clinical practice regarding perioperative treatment and follow-up of borderline ovarian tumours (BOTs) patients amongst gynaecologic oncologists, which may lead to over- and undertreatment. The aim of the study was to map the Dutch gynaecologists' preferred treatment and follow-up strategy in case of BOTs.

Methods: A questionnaire was sent to all Dutch gynaecologists involved in ovarian surgery with perioperative frozen section analysis, and the outcomes were assessed using descriptive statistics. Read More

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http://dx.doi.org/10.1016/j.gore.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297066PMC
February 2019
3 Reads

Ovarian Combined Low-grade Serous and Mesonephric-like Adenocarcinoma: Further Evidence for A Mullerian Origin of Mesonephric-like Adenocarcinoma.

Int J Gynecol Pathol 2018 Dec 19. Epub 2018 Dec 19.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.) The Fingerland Department of Pathology, Charles University Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic (H.V., J.L.).

Mesonephric-like adenocarcinomas are rare neoplasms occurring in the uterine corpus and ovary which bear a close morphologic resemblance to cervical mesonephric adenocarcinomas. They also have a similar immunophenotype and harbor similar molecular abnormalities to mesonephric adenocarcinomas and it is debated whether they are truly of mesonephric origin or represent Mullerian neoplasms closely mimicking mesonephric adenocarcinomas. We report an unusual case with bilateral ovarian serous borderline tumors and extraovarian low-grade serous carcinoma (invasive implants). Read More

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http://dx.doi.org/10.1097/PGP.0000000000000573DOI Listing
December 2018
2 Reads

Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature.

J Ovarian Res 2018 Dec 14;11(1):100. Epub 2018 Dec 14.

Department of Radiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.

Background: Ovarian granulosa cell tumors (GCTs) are divided into adult GCT (AGCT) and juvenile GCT (JGCT). The AGCT is more common type, conversely, less than 5% of tumors are the JGCT and occur in mainly premenarchal girls and in women younger than 30 years. Although JGCT have different histologic features compared to AGCT, the two types have similar imaging features because they have similar gross appearance. Read More

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http://dx.doi.org/10.1186/s13048-018-0474-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293549PMC
December 2018
3 Reads

Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8042-8059

Gynecological Oncology, National Cancer Institute, Aviano, Italy.

Objective: Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. Read More

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http://dx.doi.org/10.26355/eurrev_201811_16434DOI Listing
November 2018
4 Reads

The value of MR-detectable ipsilateral ovaries in characterizing the origin and malignancy of an adnexal tumors.

Eur J Radiol 2018 Dec 26;109:62-67. Epub 2018 Oct 26.

Department of Radiology, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai 201508, China. Electronic address:

Objective: To investigate the magnetic resonance (MR) imaging morphological relationship between adnexal tumors and the ipsilateral ovaries to characterize the origin and malignancy of tumors.

Material And Methods: Clinical and MR imaging data of 496 adnexal tumors confirmed by histology (ovary tumors, n = 400, non-ovarian tumors, n = 96; benign tumors, n = 183, borderline tumors, n = 120, and malignant tumors, n = 193) were retrospectively analyzed. The presence and shape of the ipsilateral ovaries within the context of adnexal tumors of different origins, malignancies and configurations were evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183037
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http://dx.doi.org/10.1016/j.ejrad.2018.10.027DOI Listing
December 2018
14 Reads

ABO Blood Type Has No Impact on Survival in Patients with Epithelial Ovarian Cancer.

J Cancer 2018 21;9(23):4334-4340. Epub 2018 Oct 21.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Evidence for an association between ABO blood type and epithelial ovarian cancer (EOC) survival has so far been limited and conflictive. This study applied a retrospective cohort and included 627 EOC patients diagnosed at Shengjing Hospital of China Medical University between 2011 and 2015. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) between the ABO blood type and progression-free survival (PFS) and overall survival (OS) of EOC patients were assessed using multivariable Cox proportional regression models. Read More

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http://www.jcancer.org/v09p4334.htm
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http://dx.doi.org/10.7150/jca.27734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277646PMC
October 2018
17 Reads

Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial‑mesenchymal transition.

Oncol Rep 2019 Feb 27;41(2):917-927. Epub 2018 Nov 27.

Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Metastasis is the most common cause of death in ovarian cancer patients but remains largely untreated. Epithelial‑mesenchymal transition (EMT) is critical for the conversion of early‑stage ovarian tumors into metastatic malignancies. Thus, investigating the signaling pathways promoting EMT may identify potential targets for the treatment of metastatic ovarian cancer. Read More

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http://dx.doi.org/10.3892/or.2018.6888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313075PMC
February 2019
8 Reads
2.191 Impact Factor

Ovarian Endometrioid Carcinoma Misdiagnosed as Mucinous Carcinoma: An Underrecognized Problem.

Int J Gynecol Pathol 2018 Nov 21. Epub 2018 Nov 21.

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada (R.W., M.K.) Hollings Cancer Center and Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina (L.E.K.).

Primary mucinous carcinoma of the ovary is uncommon, and while numerous studies have focused on improving our ability to distinguish these tumors from gastrointestinal metastases, recent data suggest that up to one fifth are still misdiagnosed with a previously underrecognized culprit: endometrioid carcinoma. Using an index case of an ovarian endometrioid carcinoma with mucinous differentiation masquerading as a mucinous carcinoma, we sought to identify the most efficient biomarker combination that could distinguish these 2 histotypes. Eight immunohistochemical markers were assessed on tissue microarrays from 183 endometrioid carcinomas, 77 mucinous carcinomas, and 72 mucinous borderline tumors. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000564DOI Listing
November 2018
19 Reads

MALDI-Imaging for Classification of Epithelial Ovarian Cancer Histotypes from a Tissue Microarray Using Machine Learning Methods.

Proteomics Clin Appl 2019 01 14;13(1):e1700181. Epub 2018 Dec 14.

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Purpose: Precise histological classification of epithelial ovarian cancer (EOC) has immanent diagnostic and therapeutic consequences, but remains challenging in histological routine. The aim of this pilot study is to examine the potential of matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry in combination with machine learning methods to classify EOC histological subtypes from tissue microarray.

Experimental Design: Formalin-fixed-paraffin-embedded tissue of 20 patients with ovarian clear-cell, 14 low-grade serous, 19 high-grade serous ovarian carcinomas, and 14 serous borderline tumors are analyzed using MALDI-Imaging. Read More

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http://dx.doi.org/10.1002/prca.201700181DOI Listing
January 2019
16 Reads

Safety and fertility outcomes after the conservative treatment of endometrioid borderline ovarian tumours.

BMC Cancer 2018 Nov 23;18(1):1160. Epub 2018 Nov 23.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100730, People's Republic of China.

Background: Because of the rarity of endometrioid borderline ovarian tumours (EBOTs), there is a paucity of data concerning the natural history and prognosis of this condition. Thus, the objective of our study was to establish the feasibility of fertility preservation in young women with EBOTs, as well as their oncological and reproductive outcomes.

Methods: Consecutive patients with EBOTs, treated at a tertiary referral centre during a span of 22 years, were retrospectively analysed. Read More

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http://dx.doi.org/10.1186/s12885-018-5091-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251198PMC
November 2018
5 Reads

Decreased expression of peroxiredoxin1 inhibits proliferation, invasion, and metastasis of ovarian cancer cell.

Onco Targets Ther 2018 2;11:7745-7761. Epub 2018 Nov 2.

Department of Gynaecology and Obstetrics, Shengjing Hospital Affiliated to China Medical University, Heping District, Shenyang 110004, Liaoning, China,

Aim: The aim of this study was to explore the expression of peroxiredoxin1 (PRDX1) in epithelial ovarian cancer, analyze the relationship between PRDX1 and clinicopathologic parameters of patients with ovarian cancer, including their prognosis, and describe changes and the mechanisms involved in malignant biologic behavior of ovarian cancer cells when PRDX1 expression is inhibited.

Methods: The expression of PRDX1 was detected immunohistochemically in 15 samples of normal ovarian tissue, 21 benign, 11 borderline, and 101 malignant epithelial ovarian tumors. Changes in ovarian cancer cell proliferation, invasion, and metastasis before and after inhibiting PRDX1 expression were assessed by cell function assay. Read More

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http://dx.doi.org/10.2147/OTT.S175009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223347PMC
November 2018
15 Reads

The impact of clinicopathologic and surgical factors on relapse and pregnancy in young patients (≤40 years old) with borderline ovarian tumors.

BMC Cancer 2018 Nov 21;18(1):1147. Epub 2018 Nov 21.

Department of Gynecological Oncology, Zhejiang Cancer Hospital, 1 Banshan East Road, Hangzhou, 310022, Zhejiang Province, China.

Background: Fertility sparing surgery has been extensively performed among patients with borderline ovarian tumors due to their age and favorable prognosis. Nevertheless, the prognosis and obstetric outcomes in these patients remain uncertain. Thus, the current study was carried out to evaluate the oncological safety and fertility benefits of different fertility sparing surgery subtypes and various clinicopathological parameters. Read More

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http://dx.doi.org/10.1186/s12885-018-4932-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249857PMC
November 2018
15 Reads

Alteration of BRCA-1 tumor suppressor gene expression in serous and mucinous ovarian neoplasms in the benign-borderline-malignant pathway.

Curr Probl Cancer 2018 Nov 6. Epub 2018 Nov 6.

Department of Pathology, Faculty of Medicine, Taibah University, Almadinah Almunawwarah, Saudi Arabia; Department of Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt. Electronic address:

Alteration of expression of the tumor suppressor gene BRCA-1 has been widely studied in breast and ovarian carcinoma. However, pattern of this alteration in the benign-borderline-carcinoma sequence in serous and mucinous ovarian neoplasms have not yet fully described. Tissue sections from 214 formalin-fixed paraffin-embedded ovarian specimens were stained immunohistochemically with BRCA-1 antibody. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01470272183027
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http://dx.doi.org/10.1016/j.currproblcancer.2018.10.003DOI Listing
November 2018
17 Reads

Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma.

Diagn Pathol 2018 Nov 14;13(1):87. Epub 2018 Nov 14.

Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 20032, China.

Background: Regulated in development and DNA damage response (REDD1), a gene responding to hypoxia or multiple DNA damage events, was recently implicated in cancer development and progression. Previously, in vivo and in vitro experiments indicated that REDD1 functions as an oncogene in ovarian cancer cells. However, the role of REDD1 in cancer cell migration and invasion and in clinical significance of prognostic values is not examined in detail. Read More

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http://dx.doi.org/10.1186/s13000-018-0754-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236897PMC
November 2018
25 Reads

Annual report of the committee on gynecologic oncology, the Japan Society of Obstetrics and Gynecology: Annual patients report for 2015 and annual treatment report for 2010.

J Obstet Gynaecol Res 2019 Feb 13;45(2):289-298. Epub 2018 Nov 13.

Department of Obstetrics and Gynecology, Niigata University Medical School, Niigata, Japan.

Aim: To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2015 and the Annual Treatment Report for 2010 on the outcomes of patients who started treatment in 2010.

Methods: The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment was initiated in 2015 were analyzed retrospectively. Read More

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http://doi.wiley.com/10.1111/jog.13863
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http://dx.doi.org/10.1111/jog.13863DOI Listing
February 2019
14 Reads

Synchronous endometrial and ovarian cancer in Lynch syndrome with a germline mutation: A case report.

Mol Clin Oncol 2018 Nov 17;9(5):479-484. Epub 2018 Sep 17.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Synchronous endometrial and ovarian cancer (SEOC) is a rare entity among gynecological cancers, which exhibits endometrioid histology in its early stages and generally has a good prognosis. However, diagnosis is difficult and recent reports have demonstrated that most clinically diagnosed cases of SEOC have clonally related cancers, indicating metastatic cancer. The association of SEOC with Lynch syndrome is also not clearly understood. Read More

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http://dx.doi.org/10.3892/mco.2018.1723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201051PMC
November 2018
3 Reads

Comparison of Primary Tumor Size in Stage I and III Epithelial Ovarian Cancer.

Anticancer Res 2018 Nov;38(11):6507-6511

Department of Obstetrics and Gynecology, Division of Gynecology, LKH University Hospital Graz, Graz, Austria.

Background: Two studies have found primary ovarian carcinomas in stage I disease to be larger than those in stage III. Thus, these stages may represent different tumor entities.

Materials And Methods: The clinical data from 553 patients operated on between 1985 and 2012 for epithelial ovarian cancer were retrospectively analyzed. Read More

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http://dx.doi.org/10.21873/anticanres.13015DOI Listing
November 2018
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Assessment of diagnostic utility of multivariate diagnostic models in differential diagnosis of ovarian tumors.

Ginekol Pol 2018 ;89(10):568-572

Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Poland.

Introduction: Ovarian cancer (OC) diagnosis remains a clinical challenge due to lack of early symptoms and insufficient accuracy of the available diagnostic methods. The purpose of this study was to determine whether osteopontin could be useful in differential diagnosis of ovarian tumors.

Material And Methods: Serum samples from 92 patients qualified for surgical treatment due to ovarian mass were divided into 2 groups according to the histopathological result: OC including borderline ovarian tumors (n = 39) and benign ovarian tumors (BOTs) (n = 53). Read More

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https://journals.viamedica.pl/ginekologia_polska/article/vie
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http://dx.doi.org/10.5603/GP.a2018.0097DOI Listing
April 2019
15 Reads