4 results match your criteria BoneKEy osteovision[Journal]

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Adaptive and Injury Response of Bone to Mechanical Loading.

Bonekey Osteovision 2012 Oct;1

Orthopaedic Surgery/Campus Box 8233, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, Office .

Bone responds to supraphysiological mechanical loads by increasing bone formation. Depending on the applied strain magnitude (and other loading parameters) the response can be either adaptive (mostly lamellar bone) or injury (mostly woven bone). Seminal studies of Hert, Lanyon, and Rubin originally established the basic "rules" of bone mechanosensitivity. Read More

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http://dx.doi.org/10.1038/bonekey.2012.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595617PMC
October 2012
3 Reads

Anti-Glucosaminidase Monoclonal Antibodies as a Passive Immunization for Methicillin-Resistant Staphylococcus aureus (MRSA) Orthopaedic Infections.

Bonekey Osteovision 2011 Apr;8:187-194

The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA.

Recently, methicillin-resistant Staphylococcus aureus (MRSA) has surpassed HIV as the most deadly pathogen in the United States, accounting for over 100,000 deaths per year. In orthopedics, MRSA osteomyelitis has become the greatest concern in patient care, despite the fact that improvements in surgical technique and aggressive antibiotic prophylaxis have decreased the infection rate for most procedures to less than 5%. This great concern is largely due to the very poor outcomes associated with MRSA osteomyelitis, which includes 30-50% failure rates for revision surgery. Read More

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http://dx.doi.org/10.1138/20110506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274364PMC
April 2011
2 Reads

Mechanical Signals As a Non-Invasive Means to Influence Mesenchymal Stem Cell Fate, Promoting Bone and Suppressing the Fat Phenotype.

Bonekey Osteovision 2009 Apr;6(4):132-149

Diabetes Research Center, Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, Bronx, NY, USA.

Pluripotent mesenchymal stem cells (MSCs) are considered ideal therapeutic targets in regenerative medicine, as they hold the capacity to differentiate into higher order connective tissues. The potential to harness MSCs for disease treatment and acceleration of repair will ultimately depend on an improved understanding of how physical and/or chemical signals regulate their activity, and the ability of exogenous stimuli to enhance MSC proliferation and define MSC fate. Recent appreciation that bone marrow osteoprogenitors are inversely proportional to adipocyte precursors suggests that their shared progenitor, the MSC, will commit to one lineage at the cost of the other. Read More

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http://www.nature.com/doifinder/10.1138/20090371
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http://dx.doi.org/10.1138/20090371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255555PMC
April 2009
5 Reads

Mechanosensation and Transduction in Osteocytes.

Authors:
Lynda F Bonewald

Bonekey Osteovision 2006 Oct;3(10):7-15

University of Missouri-Kansas City School of Dentistry, Kansas City, Missouri, USA.

There may be no single mechanoreceptor in osteocytes, but instead a combination of events that has to be triggered for mechanosensation and transduction of signal to occur. Possibilities include shear stress along dendritic processes and/or the cell body, cell deformation in response to strain, and primary cilia. These events could occur independently or simultaneously to activate mechanotransduction. Read More

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http://www.nature.com/doifinder/10.1138/20060233
Publisher Site
http://dx.doi.org/10.1138/20060233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847717PMC
October 2006
20 Reads
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