277 results match your criteria Bone reports[Journal]


Skeletal abnormalities secondary to antenatal etidronate treatment for suspected generalised arterial calcification of infancy.

Bone Rep 2020 Jun 13;12:100280. Epub 2020 May 13.

Department of Paediatric Endocrinology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Background: Generalised arterial calcification of infancy (GACI) is a rare disorder characterised by the deposition of hydroxyapatite crystals within the vessel walls. It is associated with a high mortality rate. Bisphosphonates have been used with some success in the treatment of GACI. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256299PMC

Osteoclasts and their circulating precursors in rheumatoid arthritis: Relationships with disease activity and bone erosions.

Bone Rep 2020 Jun 15;12:100282. Epub 2020 May 15.

Division of Rheumatology, Department of Medicine, Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, QC, Canada.

Patients with rheumatoid arthritis (RA) have very different outcomes, particularly with regard to bone erosions. Since osteoclasts are responsible for bone destruction adjacent to rheumatoid synovium, profiling osteoclasts from circulating precursors in RA could help identify patients at risk for bone destruction. In this study, we sought to determine whether the functional characteristics of osteoclasts generated from their blood precursors were modified by RA activity or were intrinsic to osteoclasts and associated with the RA phenotype (erosive or not). Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251539PMC

Osteocyte lacunar strain determination using multiscale finite element analysis.

Bone Rep 2020 Jun 19;12:100277. Epub 2020 May 19.

Department of Civil and Mechanical Engineering, University of Missouri-Kansas City, 350L Flarsheim Hall, 5100 Rockhill Road, Kansas City, MO 64110, United States of America.

Osteocytes are thought to be the primary mechanosensory cells within bone, regulating both osteoclasts and osteoblasts to control load induced changes in bone resorption and formation. Osteocytes initiate intracellular responses including activating the Wnt/β-catenin signaling pathway after experiencing mechanical forces. In response to changing mechanical loads (strain) the osteocytes signal to cells on the bone surface. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251370PMC

A degenerative medial meniscus retains some protective effect against osteoarthritis-induced subchondral bone changes.

Bone Rep 2020 Jun 16;12:100271. Epub 2020 May 16.

B3OA, UMR CNRS 7052, Inserm U1271 Université de Paris, Paris, France.

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http://dx.doi.org/10.1016/j.bonr.2020.100271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251536PMC

Assessment of baseline bone turnover marker levels and response to risedronate treatment: Data from a Japanese phase III trial.

Bone Rep 2020 Jun 25;12:100275. Epub 2020 Apr 25.

Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Risedronate increases bone mineral density (BMD) and reduces fracture risk, but treatment response may depend on the baseline state of bone turnover. Data regarding the selection of therapeutic drugs or the prediction of therapeutic effects with baseline levels of bone turnover markers (BTMs) as a reference are insufficient. We hypothesized that when the baseline levels of BTMs are higher, baseline BMD might be lower, changes in BMD at 12 months after risedronate treatment might be higher, and the reduction of fracture incidence might be greater. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240327PMC

Gnathodiaphyseal dysplasia is not recapitulated in a respective mouse model carrying a mutation of the Ano5 gene.

Bone Rep 2020 Jun 14;12:100281. Epub 2020 May 14.

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Mutations in the gene , encoding for the transmembrane protein Anoctamin 5 (Ano5), have been identified to cause gnathodiaphyseal dysplasia (GDD) in humans, a skeletal disorder characterized by sclerosis of tubular bones, increased fracture risk and fibro-osseous lesions of the jawbones. To better understand the pathomechanism of GDD we have generated via Crispr/CAS9 gene editing a mouse model harboring the murine equivalent (Ano5 p.T491F) of a GDD-causing mutation identified in a previously reported patient. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235620PMC

Circulating sclerostin is associated with bone mineral density independent of HIV-serostatus.

Bone Rep 2020 Jun 11;12:100279. Epub 2020 May 11.

Columbia University Medical Center, New York, NY, United States of America.

Background: Low bone mineral density (BMD) is commonly observed in people living with HIV (PLWH), however the cause for this BMD loss remains unclear. Sclerostin, a bone-derived antagonist to the Wnt/β-catenin-pathway, suppresses bone remodeling and is positively associated with BMD. The goal of the current study was to investigate associations between sclerostin and BMD in a cohort of HIV-seropositive and demographically-matched seronegative women. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235609PMC

A 39 year-old woman with milk-alkali syndrome complicated by posterior reversible encephalopathy syndrome.

Bone Rep 2020 Jun 4;12:100278. Epub 2020 May 4.

Grand Strand Medical Center, 809 82nd Pkwy, Myrtle Beach, SC 29572, United States.

Milk-alkali syndrome (MAS) is characterized by the triad of hypercalcemia, metabolic alkalosis, and acute kidney injury. Once thought to be a rare condition, there has been a resurgence of cases due to the consumption of calcium-containing supplements for osteoporosis prevention and dyspepsia in the general population. We describe the case of a female who presented with acute encephalopathy, hypercalcemia, and new-onset seizure. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235952PMC

Lessons learnt from delayed diagnosis of FGF-23-producing tumour-induced osteomalacia and post-operative hungry bone syndrome.

Authors:
S Kumar T Diamond

Bone Rep 2020 Jun 6;12:100276. Epub 2020 May 6.

St George Public Hospital, Kogarah, NSW 2217, Australia.

Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by a fibroblast growth-factor-23 (FGF-23)-secreting phosphaturic mesenchymal tumour (PMT) and is characterised by hypophosphataemic osteomalacia. We present a 36-year-old man initially presenting with diffuse bone and joint pain who was inappropriately treated for presumed ankylosing spondylitis for 2 years. Whole-body bone scan suggested metabolic bone disease, prompting referral to our endocrine institution. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235936PMC

The effects of vitamin K-rich green leafy vegetables on bone metabolism: A 4-week randomised controlled trial in middle-aged and older individuals.

Bone Rep 2020 Jun 26;12:100274. Epub 2020 Apr 26.

School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.

Background: High vegetable intake is associated with beneficial effects on bone. However, the mechanisms remain uncertain. Green leafy vegetables are a rich source of vitamin K1, which is known to have large effects on osteoblasts and osteocalcin (OC) metabolism. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235933PMC

Comparison of different microCT-based morphology assessment tools using human trabecular bone.

Bone Rep 2020 Jun 4;12:100261. Epub 2020 May 4.

Institute for Lightweight Design and Structural Biomechanics, TU-Wien, Vienna, Austria.

MicroCT-based morphological parameters are often used to quantify the structural properties of trabecular bone. Various software tools are available for calculating these parameters. Studies that examine the comparability of their results are rare. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235944PMC

What is the relationship between bone turnover markers and skeletal-related events in patients with bone metastases from solid tumors and in patients with multiple myeloma? A systematic review and meta-regression analysis.

Bone Rep 2020 Jun 23;12:100272. Epub 2020 Apr 23.

Department of Medical Oncology, Sun Yat-sen University Cancer Center, No. 651 East Dong Feng Road, Guangzhou 510060, China.

Introduction: As a result of the negative impact of bone metastases on patient quality of life, it is important to identify patients at increased risk of skeletal-related events (SREs). Biochemical markers produced by osteoblasts and osteoclasts may provide an early indicator of treatment response to antiresorptive therapy. We aimed to explore the relationship between change in the urinary bone turnover marker cross-linked N-terminal telopeptide of type 1 collagen (uNTX) at the earliest time of steady state and risk of SREs. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215099PMC

Age-related and sex-specific effects on architectural properties and biomechanical response of the C57BL/6N mouse femur, tibia and ulna.

Bone Rep 2020 Jun 23;12:100266. Epub 2020 Apr 23.

University of Missouri-Kansas City, Department of Civil and Mechanical Engineering, 350K Robert H. Flarsheim Hall, 5110 Rockhill Road, Kansas City, MO 64110, USA.

Aging is known to reduce bone quality and bone strength. We sought to determine how aging affects the biomechanical and architectural properties of various long bones, and if sex influences age related differences/changes. While researchers have extensively studied these changes in individual bones of mice, there is no comprehensive study of the changes in the bones from the same mice to study the changes with aging. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215114PMC

Altered topological blueprint of trabecular bone associates with skeletal pathology in humans.

Bone Rep 2020 Jun 28;12:100264. Epub 2020 Apr 28.

Faculty of Dentistry, McGill University, 2001 Avenue McGill College, Montréal, QC H3A 1G1, Canada.

Bone is a hierarchically organized biological material, and its strength is usually attributed to overt factors such as mass, density, and composition. Here we investigate a covert factor - the topological blueprint, or the network organization pattern of trabecular bone. This generally conserved metric of an edge-and-node simplified presentation of trabecular bone relates to the average coordination/valence of nodes and the equiangular 3D offset of trabeculae emanating from these nodes. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218160PMC

A review of the latest insights into the mechanism of action of strontium in bone.

Bone Rep 2020 Jun 24;12:100273. Epub 2020 Apr 24.

Department of Biomedical Engineering, Ryerson University, Toronto M5B 2K3, Ontario, Canada.

Interest in strontium (Sr) has persisted over the last three decades due to its unique mechanism of action: it simultaneously promotes osteoblast function and inhibits osteoclast function. While this mechanism of action is strongly supported by studies and small animal trials, recent large-scale clinical trials have demonstrated that orally administered strontium ranelate (SrRan) may have no anabolic effect on bone formation in humans. Yet, there is a strong correlation between Sr accumulation in bone and reduced fracture risk in post-menopausal women, suggesting Sr acts a purely physiochemical mechanism to enhance bone strength. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210412PMC

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells.

Bone Rep 2020 Jun 23;12:100270. Epub 2020 Apr 23.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, United States of America.

Mechanisms leading to age-related reductions in bone formation and subsequent osteoporosis are still incompletely understood. We recently demonstrated that kynurenine (KYN), a tryptophan metabolite, accumulates in serum of aged mice and induces bone loss. Here, we report on novel mechanisms underlying KYN's detrimental effect on bone aging. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210406PMC

Raman microspectroscopy demonstrates reduced mineralization of subchondral bone marrow lesions in knee osteoarthritis patients.

Bone Rep 2020 Jun 22;12:100269. Epub 2020 Apr 22.

Adelaide Medical School, The University of Adelaide, Adelaide, Australia.

Introduction: Bone marrow lesions (BMLs) are frequently identified by MRI in the subchondral bone in knee osteoarthritis (KOA). BMLs are known to be closely associated with joint pain, loss of the cartilage and structural changes in the subchondral trabecular bone (SCTB). Despite this, understanding of the nature of BMLs at the trabecular tissue level is incomplete. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210419PMC

What is the validity of self-reported fractures?

Bone Rep 2020 Jun 1;12:100256. Epub 2020 May 1.

Department of Endocrinology, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.

We assessed the validity of self-reported fractures, over a median follow-up period of 6.2 years, in a well characterized population-based cohort of 3560 postmenopausal women, aged 60-85 years, from the Fracture Risk Brussels Epidemiological Enquiry (FRISBEE) study. Incident low-traumatic (falls from a standing height or less) or non-traumatic fractures, including peripheral fractures, were registered during each annual follow-up telephone interview. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200867PMC

Transient receptor potential vanilloid 1 and 4 double knockout leads to increased bone mass in mice.

Bone Rep 2020 Jun 23;12:100268. Epub 2020 Apr 23.

Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

Calcium balance is important in bone homeostasis. The transient receptor potential vanilloid (TRPV) channel is a nonselective cation channel permeable to calcium and is activated by various physiological and pharmacological stimuli. TRPV1 and TRPV4, in particular, have important roles in intracellular Ca signaling and extracellular calcium homeostasis in bone cells. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191598PMC

Rebound-associated vertebral fractures may occur in sequential time points following denosumab discontinuation: need for prompt treatment re-initiation.

Bone Rep 2020 Jun 22;12:100267. Epub 2020 Apr 22.

Department of Rheumatology, 417 "NIMTS", Army Shared Fund Hospital, Athens, Greece.

Denosumab discontinuation has been associated with increased risk of rebound-associated multiple vertebral fractures. We report the cases of three patients, two females and one male, who had manifested rebound-associated vertebral fractures after denosumab discontinuation and sustained new vertebral fractures a few months later. Two of the patients had been previously treated with bisphosphonates. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191536PMC

Nonlinear voxel-based finite element model for strength assessment of healthy and metastatic proximal femurs.

Bone Rep 2020 Jun 1;12:100263. Epub 2020 Apr 1.

Biomechanics Section, KU Leuven, Leuven, Belgium.

Nonlinear finite element (FE) models can accurately quantify bone strength in healthy and metastatic femurs. However, their use in clinical practice is limited since state-of-the-art implementations using tetrahedral meshes involve a lot of manual work for which specific modelling software and engineering knowledge are required. Voxel-based meshes could enable the transition since they are robust and can be highly automated. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163060PMC

Analysis of muscle, hip, and subcutaneous fat in osteoporosis patients with varying degrees of fracture risk using 3T Chemical Shift Encoded MRI.

Bone Rep 2020 Jun 24;12:100259. Epub 2020 Mar 24.

New York Langone Health, Department of Radiology, NYU School of Medicine, New York, USA.

Osteoporosis (OP) is a major disease that affects 200 million people worldwide. Fatty acid metabolism plays an important role in bone health and plays an important role in bone quality and remodeling. Increased bone marrow fat quantity has been shown to be associated with a decrease in bone mineral density (BMD), which is used to predict fracture risk. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163287PMC

Radiation-induced changes to bone composition extend beyond periosteal bone.

Bone Rep 2020 Jun 28;12:100262. Epub 2020 Mar 28.

School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Background: Cancer patients receiving radiotherapy for soft tissue sarcomas are often at risk of post-irradiation (post-RTx) bone fragility fractures, but our understanding of factors controlling radiation-induced bone injury is limited. Previous studies have evaluated post-RTx changes to cortical bone composition in the periosteum of irradiated tibiae, but have not evaluated effects of irradiation in deeper tissues, such as endosteal or mid-cortical bone, and whether there are differential spatial effects of irradiation. In this study, we hypothesize that post-RTx changes to cortical bone composition are greater in endosteal compared to mid-cortical or periosteal bone. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125315PMC

RANKL-independent osteoclastogenesis in the SH3BP2 cherubism mice.

Bone Rep 2020 Jun 27;12:100258. Epub 2020 Mar 27.

Department of Biomedical Sciences and Comprehensive Care, Indiana University, School of Dentistry, Indianapolis, IN 46202, USA.

Even though the receptor activator of the nuclear factor-κB ligand (RANKL) and its receptor RANK have an exclusive role in osteoclastogenesis, the possibility of RANKL/RANK-independent osteoclastogenesis has been the subject of a long-standing debate in bone biology. In contrast, it has been reported that calvarial injection of TNF-ɑ elicits significant osteoclastogenesis in the absence of RANKL/RANK in NF-κB2- and RBP-J-deficient mice, suggesting that inflammatory challenges and secondary gene manipulation are the prerequisites for RANKL/RANK-deficient mice to develop osteoclasts . Here we report that, even in the absence of RANKL ( ), cherubism mice ( ) harboring the homozygous gain-of-function mutation in SH3-domain binding protein 2 (SH3BP2) develop tartrate-resistant acid phosphatase (TRAP)-positive multinucleated osteoclasts spontaneously. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118294PMC

Association between intracortical microarchitecture and the compressive fatigue life of human bone: A pilot study.

Bone Rep 2020 Jun 5;12:100254. Epub 2020 Mar 5.

Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada.

Many mechanical properties of cortical bone are largely governed by the underlying microarchitecture; however, the influence of microarchitecture on the fatigue life of bone is poorly understood. Furthermore, imaging-based studies investigating intracortical microarchitecture may expose bone samples to large doses of radiation that may compromise fatigue resistance. The purpose of this pilot study was to 1) investigate the relationship between intracortical microarchitecture and the fatigue life of human bone in compression and 2) examine the effects of synchrotron irradiation on fatigue life measurements. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110329PMC

No evidence for alteration in early secondary mineralization by either alendronate, teriparatide or combination of both in transiliac bone biopsy samples from postmenopausal osteoporotic patients.

Bone Rep 2020 Jun 27;12:100253. Epub 2020 Feb 27.

Regional Bone Center and Clinical Research Center, Helen Hayes Hospital, West Haverstraw, NY, USA.

The influence of treatment with alendronate (ALN), teriparatide (TPTD) or concurrent treatment with both on the human bone matrix mineralization has not yet been fully elucidated. For this purpose we analyzed quadruple fluorochrome labelled transiliac bone biopsy samples ( = 66) from postmenopausal osteoporotic women with prior and ongoing ALN (ALN-Rx arm) or without ALN (Rx-Naïve arm) after 7 months treatment with cyclic or daily TPTD or without TPTD using quantitative backscattered electron imaging and confocal scanning laser microscopy. Additionally to the bone mineralization density distribution (BMDD) of entire cancellous and cortical compartments, we measured the mineralization kinetics, i. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090359PMC

Corrigendum to "Skeletal disease in a father and daughter with a novel monoallelic WNT1 mutation" [Bone Rep. 9 (2018) 154-158].

Bone Rep 2020 Jun 14;12:100252. Epub 2020 Mar 14.

Yale University School of Medicine, New Haven, CT, United States of America.

[This corrects the article DOI: 10.1016/j.bonr. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078292PMC

Relationships between bone mineral density, body composition, and isokinetic strength in postmenopausal women.

Bone Rep 2020 Jun 3;12:100255. Epub 2020 Mar 3.

Faculty of Physical Culture, Palacký University, Olomouc, Czech Republic.

Objectives: The increase in body fat mass (BFM) and the loss of lean body mass (LBM) or muscle strength with age affects bone mineral (BMD). These factors increase the prevalence and incidence of obesity and sarcopenia, which have unclear effects on bone mineral density. The purpose of this study was to determine how the above selected factors affect BMD. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063090PMC

Separating positional noise from neutral alignment in multicomponent statistical shape models.

Bone Rep 2020 Jun 11;12:100243. Epub 2020 Jan 11.

Department of Electrical Engineering, ESAT/PSI, KU Leuven, Kasteelpark Arenberg 10, box 2441, 3001 Leuven, Belgium.

Given sufficient training samples, statistical shape models can provide detailed population representations for use in anthropological and computational genetic studies, injury biomechanics, musculoskeletal disease models or implant design optimization. While the technique has become extremely popular for the description of isolated anatomical structures, it suffers from positional interference when applied to coupled or articulated input data. In the present manuscript we describe and validate a novel approach to extract positional noise from such coupled data. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063239PMC

Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy.

Bone Rep 2020 Jun 5;12:100250. Epub 2020 Feb 5.

Department of Orthopaedics, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.

Purpose: The classic fracture model, described by Bonnarens and Einhorn in 1984, enlists a blunt guillotine to generate a closed fracture in a pre-stabilized rodent femur. However, in less experienced hands, this technique yields considerable variability in fracture pattern and requires highly-specialized equipment. This study describes a reproducible and low-cost model of mouse fracture healing using an open femoral osteotomy. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025178PMC

GLP-2 administration in ovariectomized mice enhances collagen maturity but did not improve bone strength.

Bone Rep 2020 Jun 5;12:100251. Epub 2020 Feb 5.

Groupe études remodelage osseux et biomatériaux, GEROM, UPRES EA4658, UNIV Angers, SFR 42-08, Institut de Biologie en Santé, CHU d'Angers, 49933 Angers cedex, France.

Osteoporosis and bone fragility are progressing worldwide. Previous published literature reported a possible beneficial role of gut hormones, and especially glucagon-like peptide-2 (GLP-2), in modulating bone remodeling. As now (Gly)GLP-2 is approved in the treatment of short bowel syndrome, we thought to investigate whether such molecule could be beneficial in bone fragility. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013338PMC

Effect of a pulse-based diet and aerobic exercise on bone measures and body composition in women with polycystic ovary syndrome: A randomized controlled trial.

Bone Rep 2020 Jun 23;12:100248. Epub 2020 Jan 23.

College of Pharmacy and Nutrition, 104 Clinic Place, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, with clinical symptoms including menstrual dysfunction and hyperandrogenemia, as well as insulin resistance which is thought to be a key contributing factor to symptoms. Insulin is also thought to positively affect bone while oligo- and amenorrhea are known to negatively affect bone. Lifestyle modification is the first recommendation to treat symptoms of PCOS; however, little is known about the effect of lifestyle interventions on bone measures in this population. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016198PMC

The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement.

Bone Rep 2020 Jun 28;12:100249. Epub 2020 Jan 28.

Orthopaedic and Trauma Clinic, Department of Surgical Sciences, University of Cagliari, Lungomare Poetto, Cagliari 09126, Italy.

Diaphyseal fractures represent a complex biological entity that could often end into impaired bone-healing, with delayed union and non-union occurring up to 10% of cases. The role of the modern orthopaedic surgeon is to optimize the fracture healing environment, recognize and eliminate possible interfering factors, and choose the best suited surgical fixation technique. The impaired reparative process after surgical intervention can be modulated with different surgical techniques, such as dynamization or exchange nailing after failed intramedullary nailing. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997516PMC

Adult hypophosphatasia with a novel mutation: Report of an Indian kindred.

Bone Rep 2020 Jun 24;12:100247. Epub 2020 Jan 24.

Department of Diabetes and Endocrinology, Alchemist Hospital, Panchkula 134112, India.

Hypophosphatasia is an inborn error in metabolism characterized by low serum alkaline phosphatase (ALP) activity resulting from deactivating mutations in (also known as ), the gene that encodes the 'tissue-specific' isoenzyme of ALP. The disease exhibits significant clinical heterogeneity that spans from death to only dental complications in adult life. Herein, we report a 47-year-old woman presenting with fracture of shaft of left femur. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997823PMC

Spondylo-epi-metaphyseal dysplasia due to a homozygous missense mutation in the gene encoding Matrilin-3 (T120M).

Bone Rep 2020 Jun 11;12:100245. Epub 2020 Jan 11.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh, India.

Introduction: Spondylo-epi-metaphyseal dysplasia (SEMD) represents a group of osteo-chondrodysplasias characterized by vertebral, epiphyseal as well as metaphyseal abnormalities. Several genes have been identified underlying the different forms.

Methodology And Results: Two relatives (cousins) in a family were found to have disproportionate short stature with clinical and radiological features suggestive of SEMD. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997811PMC

6'-Methoxy Raloxifene-analog enhances mouse bone properties with reduced estrogen receptor binding.

Bone Rep 2020 Jun 17;12:100246. Epub 2020 Jan 17.

Department of Biomedical Engineering, Indiana University-Purdue University at Indianapolis, Indianapolis, IN, USA.

Raloxifene (RAL) is an FDA-approved drug used to treat osteoporosis in postmenopausal women. RAL suppresses bone loss primarily through its role as a selective estrogen receptor modulator (SERM). This hormonal estrogen therapy promotes unintended side effects, such as hot flashes and increased thrombosis risk, and prevents the drug from being used in some patient populations at-risk for fracture, including children with bone disorders. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992940PMC

Metabolic factors and hip fracture risk in a large Austrian cohort study.

Bone Rep 2020 Jun 13;12:100244. Epub 2020 Jan 13.

Agency for Preventive and Social Medicine, Rheinstr. 61, 6900 Bregenz, Austria.

To explore the association of incident hip fractures with metabolic syndrome (MetS) and its single components, we designed a prospective cohort study of hip fracture incidence among 117,053 participants of a population-based health surveillance program in Vorarlberg, the westernmost Austrian province. Incident hip fractures were recorded between 5 and 10 years after inclusion at baseline from 2003 to 2009. Applying Cox proportional hazard models for each MetS component and for a composite z-score for MetS, hazards for fracture were estimated in quintiles, as continuous z-score variables, and as pathological cut off values. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965713PMC

Generation of an immunodeficient mouse model of tcirg1-deficient autosomal recessive osteopetrosis.

Bone Rep 2020 Jun 7;12:100242. Epub 2020 Jan 7.

CNR-IRGB, Milan Unit, via Fantoli 16/15, 20138 Milan, Italy.

Background: Autosomal recessive osteopetrosis is a rare skeletal disorder with increased bone density due to a failure in osteoclast bone resorption. In most cases, the defect is cell-autonomous, and >50% of patients bear mutations in the gene, encoding for a subunit of the vacuolar proton pump essential for osteoclast resorptive activity. The only cure is hematopoietic stem cell transplantation, which corrects the bone pathology by allowing the formation of donor-derived functional osteoclasts. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953598PMC

FGF21, not GCN2, influences bone morphology due to dietary protein restrictions.

Bone Rep 2020 Jun 31;12:100241. Epub 2019 Dec 31.

Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.

Background: Dietary protein restriction is emerging as an alternative approach to treat obesity and glucose intolerance because it markedly increases plasma fibroblast growth factor 21 (FGF21) concentrations. Similarly, dietary restriction of methionine is known to mimic metabolic effects of energy and protein restriction with FGF21 as a required mechanism. However, dietary protein has been shown to be required for normal bone growth, though there is conflicting evidence as to the influence of dietary protein restriction on bone remodeling. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950640PMC

A novel missense COL10A1 mutation: c.2020G>A; p. Gly674Arg linked with the bowed legs stature in the Schmid metaphyseal chondrodysplasia-affected Chinese lineage.

Bone Rep 2020 Jun 13;12:100240. Epub 2019 Dec 13.

Department of Endocrinology and Metabolism, Henan provincial key laboratory of children's genetics and metabolic diseases, Henan children's hospital (Children's hospital affiliated to Zhengzhou University), No-33, Longhu Waihuan East road, Zhengzhou 450018, China.

To evaluate the clinical-phenotypic characteristics of Schmid metaphyseal chondrodysplasia (SMCD) inflicted by a novel missense mutation of COL10A1 gene: c.2020G > A; p.Gly674Arg. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950639PMC

Chronic hyponatremia in patients with proximal femoral fractures after low energy trauma: A retrospective study in a level-1 trauma center.

Bone Rep 2020 Jun 6;12:100234. Epub 2019 Dec 6.

Department of Trauma-, Orthopaedic- and Plastic Surgery, University Medical Center Goettingen, Goettingen, Germany.

Introduction: We evaluated the prevalence and influence of chronic hyponatremia in patients with low energy trauma. We also investigated the influence of medication and diseases on hyponatremia.

Material And Methods: This retrospective study included 314 cases of proximal femoral fracture due to low energy trauma. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940722PMC

Sex-specific responses in trabecular and cortical microstructure of tibia due to repeated irradiation from micro-computed tomography in adult CD-1 mice.

Bone Rep 2020 Jun 25;12:100232. Epub 2019 Nov 25.

Department of Kinesiology, Brock University, St. Catharines, ON, Canada.

While repeated micro-computed tomography (μCT) allows for longitudinal measurement of bone outcomes in rodent models, it is important to determine that the resulting irradiation - dependent on the frequency and number of scans - does not exceed the effects of the intervention. The objective of this study was to determine whether repeated irradiation exposure from μCT scans at 1-month intervals for a total of four scans would alter trabecular or cortical bone structure outcomes and/or bone mineral density in tibias from both male and female CD-1 mice. The right tibia of male ( = 12) and female ( = 11) CD-1 mice were scanned using μCT at 2, 3, 4, and 5 months of age, while the contralateral left tibia served as a control and was scanned only at 5 months of age. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938922PMC

DRESS syndrome in response to Denosumab: First documented case report.

Bone Rep 2020 Jun 13;12:100239. Epub 2019 Dec 13.

Department of Rheumatology, University Hospitals of Morecambe Bay NHS Foundation Trust, Ashton Road, Lancaster LA14RP, United Kingdom.

Denosumab is an antiresorptive drug targeting RANK ligand, currently licensed for postmenopausal and male osteoporosis, bone loss associated with hormone ablation in men with prostate cancer and with systemic glucocorticoid treatment, and also used in oncology for the treatment of bone metastases and unresectable giant cell tumour of bone. When used for the treatment of osteoporosis or bone loss the drug is usually well-tolerated with non-specific musculoskeletal pain being the most common side effect. However denosumab has been associated with some dermatological manifestations including dermatitis, eczema, pruritus and, less commonly, cellulitis. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933223PMC

Bone quality in fluoride-exposed populations: A novel application of the ultrasonic method.

Bone Rep 2020 Jun 7;12:100235. Epub 2019 Dec 7.

Kentucky Geological Survey, University of Kentucky, KY, USA.

Background: Various studies, mostly with animals, have provided evidence of adverse impacts of fluoride (F) on bone density, collagen and microstructure, yet its effects on overall bone quality (strength) has not been clearly or extensively characterized in human populations.

Objective: In this observational study, we assessed variation in an integrated measures of bone quality in a population exposed to wide-ranging F levels (0.3 to 15. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933268PMC

Early urine proteome changes in an implanted bone cancer rat model.

Bone Rep 2020 Jun 13;12:100238. Epub 2019 Dec 13.

Department of Biochemistry and Molecular Biology, Gene Engineering Drug and Biotechnology Beijing Key Laboratory, Beijing Normal University, Beijing 100875, China.

In this study, Walker 256 cells were implanted into rat tibiae. Urine samples were then collected on days 3, 5, 7, and 13 and were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). With label-free quantification, 25 proteins were found to change significantly in the urine of the tumor group rats compared with the proteins in the urine of the control group rats; this was even the case when there were no significant lesions identified in the Computed Tomography (CT) examination. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921149PMC

CXCR2 specific endocytosis of immunomodulatory peptide LL-37 in human monocytes and formation of LL-37 positive large vesicles in differentiated monoosteophils.

Bone Rep 2020 Jun 13;12:100237. Epub 2019 Dec 13.

Department of Molecular Immunology, Beckman Research Institute of City of Hope, 1500 E Duarte Road, Duarte, CA 9101, United States of America.

Immunomodulatory peptide cathelicidin/LL-37 induces human monocyte differentiation into a novel bone repair cell, the monoosteophil. We now demonstrate that LL-37 is endocytosed by monocytes over a period of 6 days producing large (10 × 2 μm), specialized LL-37 and integrin α3 positive vesicles. CXCR2, a membrane receptor previously associated with the binding of LL-37 to neutrophils, was co-endocytosed with LL-37 where both markers remained within the cytosol over a 16 h observation period. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921147PMC

Unique anabolic action of stem cell gene therapy overexpressing PDGFB-DSS6 fusion protein in OVX osteoporosis mouse model.

Bone Rep 2020 Jun 11;12:100236. Epub 2019 Dec 11.

Department of Medicine, Division of Regenerative Medicine, Loma Linda University, Loma Linda, California, USA.

In the present study we sought to improve the efficacy and safety of our Sca1 PDGFB stem cell gene therapy for osteoporosis in ovariectomized (OVX) mouse model. This therapy is administered by marrow transplantation. We established the promise of this approach by previously showing that this therapy in normal mice increase bone density, increased endosteal cortical and trabecular bone formation, caused de novo trabecular bone formation, increased cortical thickness and improve bone strength. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920713PMC

Global and site-specific analysis of bone in a rat model of spinal cord injury-induced osteoporosis.

Bone Rep 2020 Jun 29;12:100233. Epub 2019 Nov 29.

Department of Biomedical Engineering, Wolfson Building, University of Strathclyde, Glasgow G4 0NW, UK.

Micro-Computed Tomography bone analysis is the gold standard method for assessing trabecular and cortical bone microarchitecture in small animal bones. This technique reports morphometric parameters as averages over selected volumes of interest (VOIs). This study proposes the introduction of an additional global 2D morphometric step into the analysis process, that provides a survey of the underlying morphometric variation present throughout both trabecular and cortical bone. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920718PMC

Minimally invasive laser Doppler flowmetry is suitable for serial bone perfusion measurements in mice.

Bone Rep 2019 Dec 22;11:100231. Epub 2019 Nov 22.

Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, USA, and North Carolina State University, Raleigh, NC, USA.

In vivo laser Doppler flowmetry (LDF) has previously been used to quantify blood perfusion accurately at a single timepoint in the murine tibial metaphysis. However, this procedure entailed substantial disruption to soft tissues overlying the bone and caused notable localized inflammation for several weeks after the procedure, impeding serial measurements in the same mouse. In this study, we tested a less invasive technique to measure perfusion in the tibia with LDF and determined that it can be used serially in the same mouse without causing signs of inflammation or gait perturbations. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900537PMC
December 2019

Response rates for hip, femoral neck, and lumbar spine bone mineral density in patients treated with abaloparatide followed by alendronate: Results from phase 3 ACTIVExtend.

Bone Rep 2019 Dec 2;11:100230. Epub 2019 Nov 2.

Colorado Center for Bone Research at Panorama Orthopedics & Spine Center, Golden, CO, USA.

Abaloparatide is a selective activator of the parathyroid hormone type 1 receptor signaling pathway that favors the stimulation of bone formation. Here, we report a prospective, exploratory analysis of bone mineral density (BMD) response rates comparing sequential abaloparatide/alendronate vs placebo/alendronate across the ACTIVE and ACTIVExtend studies. BMD was measured at the lumbar spine, total hip, and femoral neck from the beginning of ACTIVE to the end of ACTIVExtend (18 months of abaloparatide or placebo followed by about 1 month for re-consent, followed by 24 months of alendronate treatment for a total of 43 months). Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883300PMC
December 2019