77 results match your criteria Bone marrow research[Journal]


BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death.

Bone Marrow Res 2018 31;2018:5742954. Epub 2018 May 31.

Research Building, Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9PS, UK.

S100A8 and S100A9 are both members of the S100 family and have been shown to play roles in myeloid differentiation, autophagy, apoptosis, and chemotherapy resistance. In this study we demonstrate that the BET-bromodomain inhibitor JQ1 causes rapid suppression of and mRNA and protein in a reversible manner. In addition, we show that JQ1 synergises with daunorubicin in causing AML cell death. Read More

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http://dx.doi.org/10.1155/2018/5742954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000862PMC

Antimicrobial-Induced Cytopenia and Bone Marrow Hypocellularity in Patients with Cirrhosis.

Bone Marrow Res 2018 14;2018:4029648. Epub 2018 May 14.

Department of Clinical Hematology, Institute of Liver & Biliary Sciences, New Delhi, India.

There is great variation in cytopenias in cirrhotic patients with same severity and hypersplenism and their causative factors are not clear. Recent studies have highlighted the role of gut microbiome in regulation of constant and emergency hematopoiesis. Broad-spectrum antibiotics can disrupt the homeostatic or adaptive microbiota in cirrhosis, leading to impaired hematopoiesis and a higher susceptibility to infections. Read More

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http://dx.doi.org/10.1155/2018/4029648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977016PMC
May 2018
3 Reads

Optimization of Murine Bone Marrow Derived Immature Dendritic Cells: A Comparative Analysis of Flask Culture Method and Mouse CD11c Positive Selection Kit Method.

Bone Marrow Res 2018 22;2018:3495086. Epub 2018 Feb 22.

Department of Virology and Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai, India.

12-14 days of culturing of bone marrow (BM) cells containing various growth factors is widely used method for generating dendritic cells (DCs) from suspended cell population. Here we compared flask culture method and commercially available CD11c Positive Selection kit method. Immature BMDCs' purity of adherent as well as suspended cell population was generated in the decreasing concentration of recombinant-murine granulocyte-macrophage colony-stimulating factor (rmGM-CSF) in nontreated tissue culture flasks. Read More

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http://dx.doi.org/10.1155/2018/3495086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842714PMC
February 2018

Comparative Analysis of Cellular and Growth Factor Composition in Bone Marrow Aspirate Concentrate and Platelet-Rich Plasma.

Bone Marrow Res 2018 25;2018:1549826. Epub 2018 Feb 25.

Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

The purpose of this study was to quantify the stem cell and growth factor (GF) contents in the bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP) prepared from whole blood using a protocol established in our laboratory. We examined 10 patients with osteonecrosis of the femoral head who were treated by autologous BMAC transplantation at our hospital between January 2015 and June 2015. We quantified CD34+ and CD31-CD45-CD90+CD105+ cells in BMAC and PRP by flow cytometry. Read More

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https://www.hindawi.com/archive/2018/1549826/
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http://dx.doi.org/10.1155/2018/1549826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845506PMC
February 2018
7 Reads

A Reliable and Reproducible Model for Assessing the Effect of Different Concentrations of -Solanine on Rat Bone Marrow Mesenchymal Stem Cells.

Bone Marrow Res 2017 22;2017:2170306. Epub 2017 Oct 22.

Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.

Αlpha-solanine (-solanine) is a glycoalkaloid present in potato . It has been of particular interest because of its toxicity and potential teratogenic effects that include abnormalities of the central nervous system, such as exencephaly, encephalocele, and anophthalmia. Various types of cell culture have been used as experimental models to determine the effect of -solanine on cell physiology. Read More

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http://dx.doi.org/10.1155/2017/2170306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671669PMC
October 2017
7 Reads

Feasibility and Efficacy of Autologous Bone Marrow Aspirate Transplantation Combined with Human Parathyroid Hormone 1-34 Administration to Treat Osteonecrosis in a Rabbit Model.

Bone Marrow Res 2017 13;2017:2484689. Epub 2017 Mar 13.

Department of Orthopedics Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

No studies have examined the transplantation of a bone marrow aspirate (BMA) containing mesenchymal stem cells (MSCs) combined with human parathyroid hormone 1-34 (hPTH1-34) administration. Therefore, we evaluated the feasibility and efficacy of autologous BMA transplantation combined with hPHT1-34 administration in a bone necrosis model. The metatarsal bones of rabbits were necrotized using liquid nitrogen, and the rabbits received a BMA transplantation or saline injection followed by hPTH1-34 (30 g/kg) or saline administration three times per week ( = 3-4 per group). Read More

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http://dx.doi.org/10.1155/2017/2484689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366770PMC
March 2017
13 Reads

Cost Implications of Comorbidity for Autologous Stem Cell Transplantation in Elderly Patients with Multiple Myeloma Using SEER-Medicare.

Bone Marrow Res 2016 18;2016:3645623. Epub 2016 Oct 18.

Division of Hematology/Oncology, Department of Medicine, Tufts Medical Center, 800 Washington St., Box 245, Boston, MA 02111, USA; Center for Health Solutions, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington St., Box 345, Boston, MA 02111, USA.

Comorbidity is more common in older patients and can increase the cost of care by increasing toxicity. Using the SEER-Medicare database from 2000 to 2007, we examined the costs and life-year benefit of Auto-HSCT for MM patients over the age of 65 by evaluating the difference over time relative to comorbidity burden. One hundred ten patients had an Auto-HSCT in the early time period (2000-2003) and 160 in the late time period (2004-2007). Read More

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http://dx.doi.org/10.1155/2016/3645623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088316PMC
October 2016
12 Reads

Awareness, Knowledge, and Acceptance of Haematopoietic Stem Cell Transplantation for Sickle Cell Anaemia in Nigeria.

Bone Marrow Res 2016 27;2016:7062630. Epub 2016 Sep 27.

Department of Haematology, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.

Sickle cell anaemia (SCA) is an inherited condition whose clinical manifestations arise from the tendency of haemoglobin to polymerize and deform red blood cells into characteristic sickle shape. Allogeneic bone marrow transplantation offers a cure. The aim of this study was to determine the level of awareness, knowledge, and acceptance of this beneficial procedure in Nigeria. Read More

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http://dx.doi.org/10.1155/2016/7062630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059514PMC
September 2016
13 Reads

A Simplified Method for the Aspiration of Bone Marrow from Patients Undergoing Hip and Knee Joint Replacement for Isolating Mesenchymal Stem Cells and In Vitro Chondrogenesis.

Bone Marrow Res 2016 11;2016:3152065. Epub 2016 Feb 11.

Arthritis Program, Orthopaedic Surgery, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8.

The procedure for aspiration of bone marrow from the femur of patients undergoing total knee arthroplasty (TKA) or total hip arthroplasty (THA) may vary from an OR (operating room) to OR based on the surgeon's skill and may lead to varied extent of clotting of the marrow and this, in turn, presents difficulty in the isolation of mesenchymal stem cells (MSCs) from such clotted bone marrow. We present a simple detailed protocol for aspirating bone marrow from such patients, isolation, and characterization of MSCs from the aspirated bone marrow specimens and show that the bone marrow presented no clotting or exhibited minimal clotting. This represents an economical source and convenient source of MSCs from bone marrow for use in regenerative medicine. Read More

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http://dx.doi.org/10.1155/2016/3152065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766320PMC
April 2016
1 Read

Role of Microvessel Density and Vascular Endothelial Growth Factor in Angiogenesis of Hematological Malignancies.

Bone Marrow Res 2016 22;2016:5043483. Epub 2016 Feb 22.

Department of Medicine, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Doiwala, Dehradun, Uttarakhand 248140, India.

Angiogenesis plays an important role in progression of tumor with vascular endothelial growth factor (VEGF) being key proangiogenic factor. It was intended to study angiogenesis in different hematological malignancies by quantifying expression of VEGF and MVD in bone marrow biopsy along with serum VEGF levels and observing its change following therapy. The study included 50 cases of hematological malignancies which were followed for one month after initial therapy along with 30 controls. Read More

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http://pubmedcentralcanada.ca/pmcc/articles/PMC4779814/pdf/B
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http://downloads.hindawi.com/journals/bmr/2016/5043483.pdf
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http://www.hindawi.com/journals/bmr/2016/5043483/
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http://dx.doi.org/10.1155/2016/5043483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779814PMC
March 2016
35 Reads

Very Long Term Stability of Mixed Chimerism after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Hematologic Malignancies.

Bone Marrow Res 2015 10;2015:176526. Epub 2015 Nov 10.

Division of Hematology, Geneva University Hospital, 1205 Geneva, Switzerland.

The objective of this study is to analyze the evolution of chimerism of all patients transplanted for hematologic malignancies in our unit during a 20-year period, alive without relapse at 1 year after allogeneic hematopoietic stem cell transplantation (HSCT). Chimerism was tested using short tandem repeat polymorphisms after separation into mononuclear cells and granulocytes by Ficoll density gradient centrifugation. Of 155 patients studied, 89 had full chimerism (FC), 36 mononuclear cells mixed chimerism (MNC-MC), and 30 granulocytic MC with or without mononuclear cells MC (Gran-MC). Read More

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http://dx.doi.org/10.1155/2015/176526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657082PMC
December 2015
25 Reads

Cigarette Smoking Is Associated with a Lower Concentration of CD105(+) Bone Marrow Progenitor Cells.

Bone Marrow Res 2015 9;2015:914935. Epub 2015 Aug 9.

Department of Orthopedic Surgery Department, Hadassah-Hebrew University Medical Center, 91120 Jerusalem, Israel.

Cigarette smoking is associated with musculoskeletal degenerative disorders, delayed fracture healing, and nonunion. Bone marrow progenitor cells (BMPCs), known to express CD105, are important in local trophic and immunomodulatory activity and central to musculoskeletal healing/regeneration. We hypothesized that smoking is associated with lower levels of BMPC. Read More

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https://www.hindawi.com/archive/2015/914935/
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http://dx.doi.org/10.1155/2015/914935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546741PMC
September 2015
7 Reads

Comparing Two Types of Rabbit ATG prior to Reduced Intensity Conditioning Allogeneic Hematopoietic SCT for Hematologic Malignancies.

Bone Marrow Res 2015 22;2015:980924. Epub 2015 Mar 22.

Division of Hematology, Geneva University Hospital and University of Geneva, Geneva, Switzerland.

Different rabbit polyclonal antilymphocyte globulins (ATGs) are used in allogeneic hematopoietic stem cell transplantation (alloHSCT) to prevent graft-versus-host disease (GvHD). We compared 2 different ATGs in alloHSCT after reduced intensity conditioning (RIC) for hematological malignancies. We reviewed 30 alloHSCT for hematologic malignancies performed between 2007 and 2010 with fludarabine and i. Read More

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http://dx.doi.org/10.1155/2015/980924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385613PMC
April 2015
19 Reads

Selective Migration of Subpopulations of Bone Marrow Cells along an SDF-1α and ATP Gradient.

Bone Marrow Res 2014 31;2014:182645. Epub 2014 Dec 31.

Reference and Translation Center for Cardiac Stem Cell Therapy, University of Rostock, 18057 Rostock, Germany ; RTC, BMFZ, Schillingallee 68, 18057 Rostock, Germany.

Both stem cell chemokine stromal cell-derived factor-1α (SDF-1α) and extracellular nucleotides such as adenosine triphosphate (ATP) are increased in ischemic myocardium. Since ATP has been reported to influence cell migration, we analysed the migratory response of bone marrow cells towards a combination of SDF-1 and ATP. Total nucleated cells (BM-TNCs) were isolated from bone marrow of cardiac surgery patients. Read More

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http://dx.doi.org/10.1155/2014/182645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294463PMC
January 2015
5 Reads
1 Citation

The RAG Model: A New Paradigm for Genetic Risk Stratification in Multiple Myeloma.

Bone Marrow Res 2014 11;2014:526568. Epub 2014 Sep 11.

Brighton and Sussex Medical School, Sussex University, Falmer, Brighton BN1 9PS, UK.

Molecular studies have shown that multiple myeloma is a highly genetically heterogonous disease which may manifest itself as any number of diverse subtypes each with variable clinicopathological features and outcomes. Given this genetic heterogeneity, a universal approach to treatment of myeloma is unlikely to be successful for all patients and instead we should strive for the goal of personalised therapy using rationally informed targeted strategies. Current DNA sequencing technologies allow for whole genome and exome analysis of patient myeloma samples that yield vast amounts of genetic data and provide a mutational overview of the disease. Read More

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http://dx.doi.org/10.1155/2014/526568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177729PMC
October 2014
4 Reads

TET2 Inhibits Differentiation of Embryonic Stem Cells but Does Not Overcome Methylation-Induced Gene Silencing.

Bone Marrow Res 2014 25;2014:986571. Epub 2014 Aug 25.

Medical Research Building, Brighton and Sussex Medical School, Sussex University, Falmer, Brighton BN1 9PS, UK ; Royal Sussex County Hospital, Brighton and Sussex University Hospitals NHS Trust, Brighton BN2 5BE, UK.

TET2 is a methylcytosine dioxygenase that is frequently mutated in myeloid malignancies, notably myelodysplasia and acute myeloid leukemia. TET2 catalyses the conversion of 5'-methylcytosine to 5'-hydroxymethylcytosine within DNA and has been implicated in the process of genomic demethylation. However, the mechanism by which TET2 loss of function results in hematopoietic dysplasia and leukemogenesis is poorly understood. Read More

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http://dx.doi.org/10.1155/2014/986571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158571PMC
October 2014
4 Reads

Molecular regulation of bone marrow metastasis in prostate and breast cancer.

Bone Marrow Res 2014 23;2014:405920. Epub 2014 Jul 23.

Health Research Institute, Research Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Iran.

Metastasis is a multistep process, which refers to the ability to leave a primary tumor through circulation toward the distant tissue and form a secondary tumor. Bone is a common site of metastasis, in which osteolytic and osteoblastic metastasis are observed. Signaling pathways, chemokines, growth factors, adhesion molecules, and cellular interactions as well as miRNAs have been known to play an important role in the development of bone metastasis. Read More

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http://dx.doi.org/10.1155/2014/405920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134798PMC
August 2014
4 Reads

Autologous Graft versus Host Disease: An Emerging Complication in Patients with Multiple Myeloma.

Bone Marrow Res 2014 4;2014:891427. Epub 2014 May 4.

Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 502, Little Rock, AR 72205, USA.

Autologous graft versus host disease (autoGVHD) is a rare transplant complication with significant morbidity and mortality. It has been hypothesized that patients with multiple myeloma might be predisposed to autoGVHD through dysregulation of the immune response resulting from either their disease, the immunomodulatory agents (IMiDs) used to treat it, or transplant conditioning regimen. Hematopoietic progenitor cell (HPC) products were available from 8 multiple myeloma patients with biopsy-proven autoGVHD, 16 matched multiple myeloma patients who did not develop autoGVHD, and 7 healthy research donors. Read More

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http://dx.doi.org/10.1155/2014/891427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024409PMC
May 2014
3 Reads

Combination of Complement-Dependent Cytotoxicity and Relative Fluorescent Quantification of HLA Length Polymorphisms Facilitates the Detection of a Loss of Heterozygosity.

Bone Marrow Res 2014 3;2014:541345. Epub 2014 Apr 3.

Laboratory of Immunogenetics, Department of Transfusion Medicine, Cell Therapeutic Agents and Hemostaseology, University Hospital of Munich, Ludwig Maximilians University, Max-Lebsche-Platz 32, 81377 Munich, Germany.

Loss of heterozygosity (LOH) is a common event in malignant cells. In this work we introduce a new approach to identify patients with loss of heterozygosity in the HLA region either at first diagnosis or after HLA mismatched allogeneic HSCT. Diagnosis of LOH requires a high purity of recipient target cells. Read More

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http://dx.doi.org/10.1155/2014/541345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996364PMC
May 2014
17 Reads

Bone marrow vascular niche: home for hematopoietic stem cells.

Bone Marrow Res 2014 14;2014:128436. Epub 2014 Apr 14.

Department of Pathophysiology, Nankai University School of Medicine, 94 Weijin Road, Tianjin 300071, China ; The Key Laboratory of Bioactive Materials, The College of Life Science, Nankai University, Ministry of Education, Tianjin 300071, China.

Though discovered later than osteoblastic niche, vascular niche has been regarded as an alternative indispensable niche operating regulation on hematopoietic stem cells (HSCs). As significant progresses gained on this type niche, it is gradually clear that the main work of vascular niche is undertaking to support hematopoiesis. However, compared to what have been defined in the mechanisms through which the osteoblastic niche regulates hematopoiesis, we know less in vascular niche. Read More

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http://dx.doi.org/10.1155/2014/128436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009113PMC
June 2014
3 Reads

Hepatitis C among Egyptian Patients Referred for Bone Marrow Examination: Seroprevalence and Analysis of Hematological Findings.

Bone Marrow Res 2014 10;2014:549716. Epub 2014 Apr 10.

Clinical Pathology Department, Kasr Al-Ainy School of Medicine, Cairo University, P.O. Box 99, Manial El-Roda, Cairo 11553, Egypt.

Hepatitis C is a significant public health problem in Egypt where the highest prevalence (14.7%) of hepatitis C virus (HCV) exists. HCV prevalence is even higher among clinical populations and groups at risk of exposure to infection. Read More

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http://dx.doi.org/10.1155/2014/549716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003745PMC

Angiogenesis and proliferation index in patients with acute leukemia: a prospective study.

Bone Marrow Res 2014 31;2014:634874. Epub 2014 Mar 31.

Department of Medicine, JIPMER, Pondicherry 605006, India.

Angiogenesis and proliferation as measured by microvessel density (MVD) and proliferation index (PI) are essential correlates of malignancy. The aim of our study was to evaluate difference between these values in AML and ALL and also to study the modulation in these parameters following achievement of remission in acute lymphoblastic leukemia. Differences between adult and adolescent cases of acute leukemia in relation to these values were also studied. Read More

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http://dx.doi.org/10.1155/2014/634874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988728PMC

Myelonecrosis: A Clinicopathological Study from a Tertiary Care Center in South India over a Twelve-Year Period.

Bone Marrow Res 2014 23;2014:890510. Epub 2014 Jan 23.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India.

Aims. To study the etiology, diagnostic features, and clinical significance of myelonecrosis. Methods. Read More

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http://dx.doi.org/10.1155/2014/890510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920973PMC
March 2014
1 Read

Validation of the EBMT Risk Score for South Brazilian Patients Submitted to Allogeneic Hematopoietic Stem Cell Transplantation.

Bone Marrow Res 2013 12;2013:565824. Epub 2013 Dec 12.

Hematology and Bone Marrow Transplantation, Clinical Hospital of Porto Alegre, 90035-903 Porto Alegre, RS, Brazil ; Laboratory of Cell Culture and Molecular Analysis of Hematopoietic Cells, Clinical Hospital of Porto Alegre, 90035-903 Porto Alegre, RS, Brazil.

Background. Allogeneic hematopoietic stem cell transplantation (HSCT) is still associated with a high transplant-related mortality rate. In 2009, the EBMT risk score was validated as a simple tool to predict the outcome after allogeneic HSCT for acquired hematological disorders. Read More

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http://dx.doi.org/10.1155/2013/565824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876681PMC
January 2014
6 Reads

The Role of miRNA in Haematological Malignancy.

Bone Marrow Res 2013 12;2013:269107. Epub 2013 Dec 12.

Brighton and Sussex Medical School, University of Sussex, Brighton, East Sussex BN1 9PS, UK.

Currently, there are over 1,800 annotated human miRNAs, many of which have tissue-specific expression. Numerous studies have highlighted their role in haematopoietic differentiation and proliferation, acting as master regulators of haematopoietic stem cell function. Aberrant expression of miRNAs has been observed in haematological cancers, exhibiting unique expression signatures in comparison to normal counterparts. Read More

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http://dx.doi.org/10.1155/2013/269107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876682PMC
March 2014
1 Read

Human mesenchymal stromal cell-mediated immunoregulation: mechanisms of action and clinical applications.

Bone Marrow Res 2013 29;2013:203643. Epub 2013 Sep 29.

Mesenchymal and Hematopoietic Stem Cell Department, Fundación Inbiomed, Foundation for Stem Cell Research, Paseo Mikeletegi 81, 20009 San Sebastián, Spain.

Mesenchymal stromal cells (MSCs) are multipotent cells found in connective tissues that can differentiate into bone, cartilage, and adipose tissue. Interestingly, they can regulate immune responses in a paracrine way and allogeneic MSCs do not elicit immune response. These properties have encouraged a number of clinical trials in a broad range of regenerative therapies. Read More

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http://downloads.hindawi.com/journals/bmr/2013/203643.pdf
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http://www.hindawi.com/journals/bmr/2013/203643/
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http://dx.doi.org/10.1155/2013/203643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804286PMC
June 2014
5 Reads

Day 100 Peripheral Blood Absolute Lymphocyte/Monocyte Ratio and Survival in Classical Hodgkin's Lymphoma Postautologous Peripheral Blood Hematopoietic Stem Cell Transplantation.

Bone Marrow Res 2013 28;2013:658371. Epub 2013 Apr 28.

Division of Hematology, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Day 100 prognostic factors of postautologous peripheral blood hematopoietic stem cell transplantation (APBHSCT) to predict clinical outcome in classical Hodgkin lymphoma (cHL) patients have not been evaluated. Thus, we studied if the day 100 peripheral blood absolute lymphocyte/monocyte ratio (Day 100 ALC/AMC) affects clinical outcomes by landmark analysis from day 100 post-APBHSCT. Only cHL patients achieving a complete remission at day 100 post-APBHSCT were studied. Read More

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http://dx.doi.org/10.1155/2013/658371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655445PMC
May 2013
11 Reads

Incidence and Pattern of Graft-versus-Host Disease in Patients Undergoing Allogeneic Transplantation after Nonmyeloablative Conditioning with Total Lymphoid Irradiation and Antithymocyte Globulin.

Bone Marrow Res 2013 17;2013:414959. Epub 2013 Apr 17.

Osborn Hematopoietic Malignancy and Transplantation Program, West Virginia University, Morgantown, WV 26506, USA.

Nonmyeloablative (NMA) conditioning with total lymphoid irradiation and antithymocyte globulin (TLI/ATG) has been shown to protect against acute graft-versus-host disease (GVHD). We report here our institutional experience with allogeneic transplantation following NMA conditioning with TLI/ATG (n = 21). GVHD prophylaxis consisted of a combination of a calcineurin inhibitor and mycophenolate mofetil. Read More

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http://dx.doi.org/10.1155/2013/414959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652129PMC
May 2013
17 Reads

High-Frequency Vibration Treatment of Human Bone Marrow Stromal Cells Increases Differentiation toward Bone Tissue.

Bone Marrow Res 2013 25;2013:803450. Epub 2013 Mar 25.

Department of Industrial and Information Sciences, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy ; Center for Tissue Engineering, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy.

In order to verify whether differentiation of adult stem cells toward bone tissue is promoted by high-frequency vibration (HFV), bone marrow stromal cells (BMSCs) were mechanically stimulated with HFV (30 Hz) for 45 minutes a day for 21 or 40 days. Cells were seeded in osteogenic medium, which enhances differentiation towards bone tissue. The effects of the mechanical treatment on differentiation were measured by Alizarin Red test, (q) real-time PCR, and protein content of the extracellular matrix. Read More

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http://dx.doi.org/10.1155/2013/803450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621160PMC
April 2013
1 Read

Adenoviral Delivery of the VEGF and BMP-6 Genes to Rat Mesenchymal Stem Cells Potentiates Osteogenesis.

Bone Marrow Res 2013 26;2013:737580. Epub 2013 Feb 26.

Orthopaedic Research Laboratories, Department of Orthopedic Surgery, University of Virginia School of Medicine, P.O. Box 800159, Charlottesville, VA 22908, USA.

The combined delivery of mesenchymal stem cells (MSCs), vascular endothelial growth factor (VEGF), and bone morphogenetic protein (BMP) to sites of bone injury results in enhanced repair compared to the administration of a single factor or a combination of two factors. Based on these findings, we hypothesized that coexpression of VEGF and BMP-6 genes would enhance the osteoblastic differentiation of rat bone-marrow-derived stem cells (rMSCs) and osteogenesis by comparison to rMSCs that do not express VEGF and BMP-6. We prepared a GFP tagged adenovirus vector (Ad-VEGF+BMP-6) that contained DNA encoding the hVEGF and hBMP-6 genes. Read More

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http://dx.doi.org/10.1155/2013/737580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600300PMC

Biological and Genetic Aspects of Donor-Recipient Matching in HSCT.

Bone Marrow Res 2012 9;2012:212593. Epub 2012 Dec 9.

Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, Poland ; National Bone Marrow Donor Registry, Lower Silesian Center for Cellular Transplantation, Wroclaw, Poland.

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http://dx.doi.org/10.1155/2012/212593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523404PMC
January 2013

Improving safety of preemptive therapy with oral valganciclovir for cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation.

Bone Marrow Res 2012 3;2012:874601. Epub 2012 Dec 3.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, 30625 Hannover, Germany.

Valganciclovir (VGC), an oral prodrug of ganciclovir (GCV), has been shown to clear cytomegalovirus (CMV) viremia in preemptive treatment of patients after allogeneic hematopoietic stem cell transplantation (alloHSCT), apparently without significant toxicity. Since VGC obviates hospitalization, it is increasingly being adopted, although not approved, in alloHSCT. When we retrospectively evaluated preemptive treatment with VGC versus GCV, foscarnet or cidofovir, in all 312 consecutive CMV viremias of 169 patients allotransplanted at our institution between 1996 and 2006, we found VGC more efficacious (79%) than non-VGC therapies (69%). Read More

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http://dx.doi.org/10.1155/2012/874601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518946PMC
December 2012
11 Reads

Both optimal matching and procedure duration influence survival of patients after unrelated donor hematopoietic stem cell transplantation.

Bone Marrow Res 2012 22;2012:873695. Epub 2012 Oct 22.

Division of the National Bone Marrow Donor Registry, Lower Silesian Center for Cellular Transplantation, Grabiszynska 105, 53-439 Wroclaw, Poland.

Eighty-six patients suffering from hematological malignancies, immunodeficiencies, and aplastic anemias received alloHSCT from unrelated donors. Donors were selected from the BMDW files and further matching was performed according to the confirmatory typing procedure with the use of PCR SSP and that based on sequencing. The time from the clinical request of the donor search to the final decision of clinicians accepting the donor was from 0. Read More

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http://dx.doi.org/10.1155/2012/873695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518791PMC
December 2012
1 Read

New rising infection: human herpesvirus 6 is frequent in myeloma patients undergoing autologous stem cell transplantation after induction therapy with bortezomib.

Bone Marrow Res 2012 29;2012:409765. Epub 2012 Nov 29.

Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, P.O. Box 9602, Haifa 31096, Israel.

Herpesvirus 6 (HHV-6) infection is a common complication during immunosuppression. Its significance for multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT) after treatment with novel agents affecting immune system remains undetermined. Data on 62 consecutive MM patients receiving bortezomib-dexamethasone (VD) (n = 41; 66%) or thalidomide-dexamethasone (TD) (n = 21, 34%) induction, together with melphalan 200 mg/m(2) autograft between 01. Read More

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http://dx.doi.org/10.1155/2012/409765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517825PMC
December 2012
6 Reads

CMV Serostatus of Donor-Recipient Pairs Influences the Risk of CMV Infection/Reactivation in HSCT Patients.

Bone Marrow Res 2012 22;2012:375075. Epub 2012 Nov 22.

Department of Clinical Immunology, L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolfa Weigla Street, 53-114 Wroclaw, Poland.

CMV donor/recipient serostatus was analyzed in 200 patients allografted in our institution from unrelated (122 patients) donors and 78 sibling donors in the years 2002-2011 in relation to posttransplant complications. On a group basis independently of the CMV serostatus of donor-recipient pairs sibling transplantations and those from unrelated donors that matched 10/10 at allele level had a similar rate of CMV reactivation (17/78 versus 19/71, P = ns). The rate of CMV reactivation/infection was higher in patients grafted from donors accepted at the lower level of matching than 10/10 (18/38 versus 36/149, P = 0. Read More

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http://dx.doi.org/10.1155/2012/375075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512215PMC
December 2012
1 Read

Differential expression of matrix metalloproteinase-2 expression in disseminated tumor cells and micrometastasis in bone marrow of patients with nonmetastatic and metastatic prostate cancer: theoretical considerations and clinical implications-an immunocytochemical study.

Bone Marrow Res 2012 26;2012:259351. Epub 2012 Nov 26.

Hematology, Division of Medicine, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa, 7770199 Santiago, Chile ; Instituto de Bio-Oncología, Avenida Salvador 95, Oficina 95, Providencia, 7500710 Santiago, Chile ; Circulating Tumor Cell Unit, Faculty of Medicine, Universidad Mayor, Renato Sánchez 4369, Las Condes, 7550224 Santiago, Chile.

Matrix metalloproteinase-2 (MMP-2) is important in the dissemination and invasion of tumor cells and activates angiogenesis. We present an immunocytochemical study of MMP-2 expression in circulating prostate cells (CPCs), disseminated tumor cells (DTCs), and micrometastasis (mM) in bone marrow of men with prostate cancer. Methods and Patients. Read More

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http://dx.doi.org/10.1155/2012/259351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513718PMC
December 2012
1 Read

Computer algorithms in the search for unrelated stem cell donors.

Authors:
David Steiner

Bone Marrow Res 2012 1;2012:175419. Epub 2012 Nov 1.

Department of Cybernetics, Czech Technical University in Prague, Karlovo Náměstí 13, 121 35 Prague 2, Czech Republic.

Hematopoietic stem cell transplantation (HSCT) is a medical procedure in the field of hematology and oncology, most often performed for patients with certain cancers of the blood or bone marrow. A lot of patients have no suitable HLA-matched donor within their family, so physicians must activate a "donor search process" by interacting with national and international donor registries who will search their databases for adult unrelated donors or cord blood units (CBU). Information and communication technologies play a key role in the donor search process in donor registries both nationally and internationaly. Read More

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http://dx.doi.org/10.1155/2012/175419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501812PMC
December 2012

Human leukocyte antigen profiles of latin american populations: differential admixture and its potential impact on hematopoietic stem cell transplantation.

Bone Marrow Res 2012 18;2012:136087. Epub 2012 Nov 18.

Clinical Research Group, The Anthony Nolan Research Institute, Royal Free & University College Medical School, London NW3 2QG, UK ; University College London Cancer Institute, London WC1E 6DD, UK ; Centro de Investigaciones en Hematología y Trastornos Afines (CIHATA), Universidad de Costa Rica, 11501-2060 San José, Costa Rica.

The outcome of hematopoietic stem cell transplantation (HSCT) is shaped by both clinical and genetic factors that determine its success. Genetic factors including human leukocyte antigen (HLA) and non-HLA genetic variants are believed to influence the risk of potentially fatal complications after the transplant. Moreover, ethnicity has been proposed as a factor modifying the risk of graft-versus-host disease. Read More

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http://dx.doi.org/10.1155/2012/136087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506882PMC
December 2012

Unrelated hematopoietic stem cell donor matching probability and search algorithm.

Authors:
J-M Tiercy

Bone Marrow Res 2012 13;2012:695018. Epub 2012 Nov 13.

National Reference Laboratory for Histocompatibility, Transplantation Immunology Unit, Department of Medical Specialties and Department of Genetics and Laboratory Medicine, Geneva University Hospitals, University of Geneva, 1211 Geneva, Switzerland.

In transplantation of hematopoietic stem cells (HSCs) from unrelated donors a high HLA compatibility level decreases the risk of acute graft-versus-host disease and mortality. The diversity of the HLA system at the allelic and haplotypic level and the heterogeneity of HLA typing data of the registered donors render the search process a complex task. This paper summarizes our experience with a search algorithm that includes at the start of the search a probability estimate (high/intermediate/low) to identify a HLA-A, B, C, DRB1, DQB1-compatible donor (a 10/10 match). Read More

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http://dx.doi.org/10.1155/2012/695018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502776PMC
December 2012

Role of killer immunoglobulin-like receptor and ligand matching in donor selection.

Bone Marrow Res 2012 10;2012:271695. Epub 2012 Nov 10.

Department of Hematology, Ankara University Unrelated Donor Registry and Cord Blood Bank, Ankara, Turkey ; Ankara Tip Fakultesi Hematoloji Bilim Dali, Cebeci Yerleskesi, Dikimevi, 06620 Ankara, Turkey.

Despite all efforts to improve HLA typing and immunosuppression, it is still impossible to prevent severe graft versus host disease (GVHD) which can be fatal. GVHD is not always associated with graft versus malignancy and can prevent stem cell transplantation from reaching its goals. Overall T-cell alloreactivity is not the sole mechanism modulating the immune defense. Read More

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http://dx.doi.org/10.1155/2012/271695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502759PMC
November 2012
3 Reads

Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors.

Bone Marrow Res 2012 8;2012:257086. Epub 2012 Nov 8.

Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Dabrowskiego 25, 40-032 Katowice, Poland.

We have examined the alleles of eleven minor histocompatibility antigens (MiHAs) and investigated the occurrence of immunogenic MiHA disparities in 62 recipients of allogeneic hematopoietic cell transplantation (allo-HCT) with myeloablative conditioning performed between 2000 and 2008 and in their HLA-matched sibling donors. Immunogenic MiHA mismatches were detected in 42 donor-recipient pairs: in 29% MiHA was mismatched in HVG direction, in another 29% in GVH direction; bidirectional MiHA disparity was detected in 10% and no MiHA mismatches in 32%. Patients with GVH-directed HY mismatches had lower both overall survival and disease-free survival at 3 years than patients with compatible HY; also higher incidence of both severe acute GvHD and extensive chronic GVHD was observed in patients with GVH-directed HY mismatch. Read More

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http://dx.doi.org/10.1155/2012/257086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502767PMC
November 2012

The Presence of Anti-HLA Antibodies before and after Allogeneic Hematopoietic Stem Cells Transplantation from HLA-Mismatched Unrelated Donors.

Bone Marrow Res 2012 24;2012:539825. Epub 2012 Oct 24.

Department of Hematology and BMT, Medical University of Silesia, Dabrowskiego 25, 40-032 Katowice, Poland.

Although anti-human leukocyte antigen antibodies (anti-HLA Abs) are important factors responsible for graft rejection in solid organ transplantation and play a role in post-transfusion complications, their role in allogeneic hematopoietic stem cell transplantation (allo-HSCT) has not been finally defined. Enormous polymorphism of HLA-genes, their immunogenicity and heterogeneity of antibodies, as well as the growing number of allo-HSCTs from partially HLA-mismatched donors, increase the probability that anti-HLA antibodies could be important factors responsible for the treatment outcomes. We have examined the incidence of anti-HLA antibodies in a group of 30 allo-HSCT recipients from HLA-mismatched unrelated donors. Read More

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http://dx.doi.org/10.1155/2012/539825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488384PMC
November 2012
1 Read

NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome.

Bone Marrow Res 2012 18;2012:180391. Epub 2012 Oct 18.

Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London NW3 2QG, UK.

Haematopoietic stem cell transplantation (HSCT) is a valuable tool in the treatment of many haematological disorders. Advances in understanding HLA matching have improved prognoses. However, many recipients of well-matched HSCT develop posttransplant complications, and survival is far from absolute. Read More

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http://dx.doi.org/10.1155/2012/180391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483648PMC
November 2012
6 Reads

Controversies and recent advances in hematopoietic cell transplantation for follicular non-hodgkin lymphoma.

Bone Marrow Res 2012 11;2012:897215. Epub 2012 Oct 11.

Myeloma and Lymphoma Service, Osborn Hematopoietic Malignancy and Transplantation Program, West Virginia University, Morgantown, WV 26506, USA.

Commonly designated as an indolent non-Hodgkin lymphoma, follicular lymphoma (FL) presents with striking pathobiological and clinical heterogeneity. Initial management strategies for FL have evolved to involve combination chemoimmunotherapy and/or radio-immunoconjugates. Unfortunately even with the best available nontransplant treatment, which nowadays results in higher frequency of response, FL remains incurable. Read More

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http://dx.doi.org/10.1155/2012/897215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477524PMC
October 2012
8 Reads

The Role of HLA in Cord Blood Transplantation.

Bone Marrow Res 2012 11;2012:485160. Epub 2012 Oct 11.

Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens (BRFAA), 4 Soranou Efessiou Street, 115 27 Athens, Greece.

In recent years, umbilical cord blood (CB), a rich source of hematopoietic stem cells (HSC), has been used successfully as an alternative HSC source to treat a variety of hematologic, immunologic, genetic, and oncologic disorders. CB has several advantages, including prompt availability of the transplant, decrease of graft versus host disease (GVHD) and better long-term immune recovery, resulting in a similar long-term survival. Studies have shown that some degree of HLA mismatches is acceptable. Read More

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https://www.hindawi.com/archive/2012/485160/
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http://dx.doi.org/10.1155/2012/485160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477523PMC
October 2012
8 Reads

Th17 mediated alloreactivity is facilitated by the pre-transplant microbial burden of the recipient.

Bone Marrow Res 2012 9;2012:960280. Epub 2012 Oct 9.

Department of Clinical Immunology, L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolfa Weigla Street, 53-114 Wroclaw, Poland.

Acute graft-versus-host disease (aGvHD) is a major complication after hematopoietic stem cell transplantation (HSCT) and severity of aGvHD is associated with biological and genetic factors related to donors and recipients. Studies on inflammatory pathways involved in aGvHD have shown a significant impact of the gut microflora on aGvHD development giving increasing evidence in the understanding of the response of innate and adaptive immunity to microbial products. Cytokine deregulation may increase or reduce the risk of aGvHD. Read More

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http://dx.doi.org/10.1155/2012/960280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472510PMC
October 2012
1 Read

Role of HLA in Hematopoietic Stem Cell Transplantation.

Bone Marrow Res 2012 2;2012:680841. Epub 2012 Oct 2.

Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.

The selection of hematopoietic stem cell transplantation (HSCT) donors includes a rigorous assessment of the availability and human leukocyte antigen (HLA) match status of donors. HLA plays a critical role in HSCT, but its involvement in HSCT is constantly in flux because of changing technologies and variations in clinical transplantation results. The increased availability of HSCT through the use of HLA-mismatched related and unrelated donors is feasible with a more complete understanding of permissible HLA mismatches and the role of killer-cell immunoglobulin-like receptor (KIR) genes in HSCT. Read More

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http://dx.doi.org/10.1155/2012/680841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467756PMC
October 2012
1 Read

Inhibition of Mammalian target of rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress.

Bone Marrow Res 2012 2;2012:329061. Epub 2012 Oct 2.

Division of Hematology, Institute of Medicine, University of Bergen, N-5021 Bergen, Norway ; Department of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway.

Effects of the mTOR inhibitor rapamycin were characterized on in vitro cultured primary human acute myeloid leukemia (AML) cells and five AML cell lines. Constitutive mTOR activation seemed to be a general characteristic of primary AML cells. Increased cellular stress induced by serum deprivation increased both mTOR signaling, lysosomal acidity, and in vitro apoptosis, where lysosomal acidity/apoptosis were independent of increased mTOR signaling. Read More

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http://dx.doi.org/10.1155/2012/329061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467767PMC
October 2012
3 Reads

What is the most appropriate source for hematopoietic stem cell transplantation? Peripheral stem cell/bone marrow/cord blood.

Bone Marrow Res 2012 27;2012:834040. Epub 2012 Sep 27.

Hematology Clinic and Hematopotic Stem Cell Transplantation Unit, Ankara Oncology Training and Research Hospital (AOH), Yenimahalle, Demetevler, 06200 Ankara, Turkey.

The introduction of peripheral stem cell (PSC) and cord blood (CB) as an alternative to bone marrow (BM) recently has caused important changes on hematopoietic stem cell transplantation (HSCT) practice. According to the CIBMTR data, there has been a significant decrease in the use of bone marrow and increase in the use of PSC and CB as the stem cell source for HSCT performed during 1997-2006 period for patients under the age of 20. On the other hand, the stem cell source in 70% of the HSCT procedures performed for patients over the age of 20 was PSC and the second most preferred stem cell source was bone marrow. Read More

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http://dx.doi.org/10.1155/2012/834040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465870PMC
October 2012
7 Reads

Influence of bisphosphonate treatment on medullary macrophages and osteoclasts: an experimental study.

Bone Marrow Res 2012 13;2012:526236. Epub 2012 Sep 13.

Histology and Embryology Department, School of Dentistry, University of Buenos Aires, Marcelo T de Alvear 2142 1 º piso sector A, (C1122AAH) Ciudad Autónoma de Buenos Aires, C1122AAH Buenos Aires, Argentina.

Nitrogen-containing bisphosphonates are widely used for treating diverse bone pathologies. They are anticatabolic drugs that act on osteoclasts inhibiting bone resorption. It remains unknown whether the mechanism of action is by decreasing osteoclast number, impairing osteoclast function, or whether they continue to effectively inhibit bone resorption despite the increase in osteoclast number. Read More

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http://dx.doi.org/10.1155/2012/526236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449103PMC
September 2012