1,210,765 results match your criteria Bone and Tissue Regeneration Insights [Journal]


Anti-depressive effect of Shuangxinfang on rats with acute myocardial infarction: Promoting bone marrow mesenchymal stem cells mobilization and alleviating inflammatory response.

Biomed Pharmacother 2018 Dec 12;111:19-30. Epub 2018 Dec 12.

The Third Affiliate Hospital of Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address:

Bone marrow mesenchymal stem cells (BM-MSCs) are recruited to injured site for cardiac self-repairing in acute myocardial infarction (AMI), but the spontaneous mobilization of BM-MSCs is insufficient for self-repairing. Inflammation initiated by necrosis cardiomyocytes induced cardiac remodeling and depression. Given the anti-inflammatory effects of BM-MSCs and the inextricably relationship among inflammation, ventricular remodeling and depression following AMI, methods focused on enhancing BM-MSCs mobilization are promising. Read More

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December 2018

Successful genetic modification of porcine spermatogonial stem cells via an electrically responsive Au nanowire injector.

Biomaterials 2018 Dec 10;193:22-29. Epub 2018 Dec 10.

Department of Animal Life Science, Kangwon National University, Chuncheon, 24341, South Korea; Department of Applied Animal Science, Kangwon National University, Chuncheon, 24341, South Korea. Electronic address:

Transgenic pigs are quite useful in many biomedical fields, such as xenotransplantation research and the production of biopharmaceutical materials. The genetic transformation of porcine spermatogonial stem cells (pSSCs) followed by differentiation into mature spermatozoa enables the effective production of transgenic pigs. Improving the transfection efficiency of pSSCs, however, has been much desired. Read More

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December 2018

Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision.

Life Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

Cyclophosphamide (CP) is an important anticancer drug which belongs to the class of alkylating agent. Cyclophosphamide is mostly used in bone marrow transplantation, rheumatoid arthritis, lupus erythematosus, multiple sclerosis, neuroblastoma and other types of cancer. Dose-related cardiotoxicity is a limiting factor for its use. Read More

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December 2018

Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: the effect of NOD2/CARD15 mutations in a Tunisian population.

Hum Immunol 2018 Dec 12. Epub 2018 Dec 12.

Immunogenetic Applied to Cells Therapy Research Unit, Immuno-Haematology and HLA-Typing Department, National Blood Transfusion Centre of Tunis, Tunis, Tunisia.

Bronchiolitis obliterans (BO) is a serious lung complication that can develop after allogenic stem cell transplantation. It has been suggested that single nucleotide polymorphisms (SNPs) that affect the NOD2/CARD15 gene impair its function and result in an uncontrolled innate immune response in the recipient, thereby leading to BO. One hundred eighty-one donor-recipient pairs were analyzed for the association between NOD2 gene variants (SNP8 [Arg702Trp], SNP12 [Gly908Arg], and SNP13 [Leu1007fsinsC]) and the occurrence of BO. Read More

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December 2018

2-Bromopalmitate sensitizes osteosarcoma cells to adriamycin-induced apoptosis via the modulation of CHOP.

Eur J Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China, 310058. Electronic address:

Osteosarcoma is the most common primary malignant bone tumour, but the survival rate of patients has plateaued since the mid-1980s. Adriamycin is an integral component of the current first-line chemotherapies used for osteosarcoma, but dose-dependent severe side effects often limit its clinical application. Here, we propose a potential combination regimen in which adriamycin plus 2-bromopalmitate, a palmitoylation inhibitor, exhibited powerful therapeutic effects on osteosarcoma. Read More

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December 2018

Calcitriol loading before total parathyroidectomy with autotransplant in patients with end stage kidney disease: Does it prevent postoperative hypocalcaemia?

Intern Med J 2018 Dec 15. Epub 2018 Dec 15.

Endocrine and General Surgery, Department of Surgery, John Hunter Hospital and Newcastle Private Hospital, Lookout Road New Lambton Heights, New South Wales, Australia, 2305.

Background: Hungry bone syndrome (HBS) is one of the most serious complications following parathyroidectomy for severe hyperparathyroidism. There is a lack of literature informing the treatment and risk factors for this condition and the ideal pre-operative strategy for prevention.

Aims: The primary aims of this study were to examine the incidence of HBS with pre-operative calcitriol loading for 10 days and to determine the risk factors for HBS. Read More

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December 2018

Bone marrow derived interstitial cells of Cajal are increased by electroacupuncture in the colon of diabetic mice.

J Gastroenterol Hepatol 2018 Dec 15. Epub 2018 Dec 15.

Division of Gastroenterology, Union Hospital, Tongji medical college, Huazhong University of Science and Technology, Wuhan, China.

Background And Aim: Insufficiency of interstitial cells of cajal (ICC) in the muscular plexus of colon has been proved in diabetic mice. Electroacupuncture (EA) at ST36 can accelerate ICC supplement in the colon of diabetic mice, but the source of increased ICC has not been clearly explored. Bone marrow cells (BMCs) possess the potential of migration and differentiation into ICC of the intestine. Read More

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December 2018

PAR2 promotes M1 macrophage polarization and inflammation via FOXO1 pathway.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.

Macrophages polarization plays essential but different roles in most diseases such as atherosclerosis, adipose tissue inflammation, and insulin resistance. Our previous study revealed that protease-activated receptor 2 (PAR2), a G-protein coupled receptor influenced macrophage function, but little is known regarding the regulation of macrophage polarization process and its potential mechanisms. In the present study, bone marrow-derived macrophages (BMDM) isolated from C57/BL6 mice and cultured with L929-conditional medium and murine macrophage cell line RAW264. Read More

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December 2018

A newly synthesized oleanolic acid derivative inhibits the growth of osteosarcoma cells in vitro and in vivo by decreasing c-MYC-dependent glycolysis.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Osteosarcoma (OS) is the primary malignant bone tumor with a peak incidence in children and adolescents. However, the little molecular mechanism of pathogenesis has been known and it is urgent to develop new therapeutical strategies to improve outcomes for patients. CDDO-NFM (N-formylmorpholine substituent of CDDO) is a newly synthesized triterpenoid, which is a derivative of oleanolic acid. Read More

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December 2018

Scutellarein inhibits RANKL-induced osteoclast formation in vitro and prevents LPS-induced bone loss in vivo.

J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Osteoporosis, arthritis, Peget's disease, bone tumor, periprosthetic joint infection, and periprosthetic loosening have a common characteristic of osteolysis, which is characterized by the enhanced osteoclastic bone resorptive function. At present, the treatment target of these diseases is to interfere with osteoclastic formation and function. Scutellarein (Scu), a flavonoids compound, can inhibit the progress of tumor and inflammation. Read More

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December 2018

FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway.

Immunol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing, 100853, China.

Fc receptor common γ signaling chain (FcRγ), a common subunit shared by Fc receptors (FcγRI, III, IV, FcαRI, and FcεRI), is an important immune regulator both in innate and adaptive immunity. Previous studies have shown that FcRγ was a potential target of inflammatory diseases, whereas the role of FcRγ in sepsis has been poorly understood. In this study, we found that deficiency of FcRγ resulted in increased survival in lipopolysaccharide (LPS)/D-galactosamine and E. Read More

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December 2018

TMJ arthrosis: does the occlusal relationship really interfere? A comparison between cone beam computed tomography and dried skulls.

Surg Radiol Anat 2018 Dec 14. Epub 2018 Dec 14.

Department of Oral Biology, University of Pittsburgh, 412 Salk Pavilion, Pittsburgh, PA, 15261, USA.

The aim of this study was to investigate the association between condylar bone morphological characteristics with occlusal conditions. Besides the study will compare the tomography images with the real condition in 122 temporomandibular joints from 61 skulls. The occlusal conditions were evaluated by number of teeth missing, measurement of overjet and overbite, in millimeters, and presence or absence of crossbite, openbite and dental rotation. Read More

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December 2018

High-resolution flat panel CT versus 3-T MR arthrography of the wrist: initial results in vivo.

Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, Medical School Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Objectives: The objective of this study was to compare the diagnostic performance of direct C-arm flat panel computed tomography arthrography (FPCT-A) with direct magnetic resonance arthrography (MR-A) of the wrist in patients with clinically suspected pathologies.

Methods: Forty-nine patients underwent tri-compartmental wrist arthrography. FPCT-A was acquired using a high-resolution acquisition mode, followed by a 3-T MR exam using a dedicated wrist coil. Read More

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December 2018

Correction to: Platelet number and graft function predict intensive care survival in allogeneic stem cell transplantation patients.

Ann Hematol 2018 Dec 14. Epub 2018 Dec 14.

Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany.

The author name Philipp Wohlfarth was incorrectly spelled as Philipp Wohlfahrth in the original version of this article. Read More

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December 2018

Lean mass and lower limb muscle function in relation to hip strength, geometry and fracture risk indices in community-dwelling older women.

Osteoporos Int 2018 Dec 14. Epub 2018 Dec 14.

Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

In a population-based sample of British women aged over 70 years old, lean mass and peak lower limb muscle force were both independently associated with hip strength and fracture risk indices, thereby suggesting a potential benefit of promoting leg muscle strengthening exercise for the prevention of hip fractures in postmenopausal women.

Introduction: To investigate cross-sectional associations of lean mass and physical performance, including lower limb muscle function, with hip strength, geometry and fracture risk indices (FRIs) in postmenopausal women.

Methods: Data were from the Cohort of Skeletal Health in Bristol and Avon. Read More

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December 2018

Plasmodium falciparum gametocyte-infected erythrocytes do not adhere to human primary erythroblasts.

Sci Rep 2018 Dec 14;8(1):17886. Epub 2018 Dec 14.

Inserm U1016, Institut Cochin, Paris, France.

Plasmodium falciparum gametocytes, the sexual stages responsible for malaria parasite transmission, develop in the human bone marrow parenchyma in proximity to the erythroblastic islands. Yet, mechanisms underlying gametocytes interactions with these islands are unknown. Here, we have investigated whether gametocyte-infected erythrocytes (GIE) adhere to erythroid precursors, and whether a putative adhesion may be mediated by a mechanism similar to the adhesion of erythrocytes infected with P. Read More

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December 2018

Aging of Antiviral CD8 Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing.

J Immunol 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045;

Aging of established antiviral T cell memory can foster a series of progressive adaptations that paradoxically improve rather than compromise protective CD8 T cell immunity. We now provide evidence that this gradual evolution, the pace of which is contingent on the precise context of the primary response, also impinges on the molecular mechanisms that regulate CD8 memory T cell (T) homeostasis. Over time, CD8 T generated in the wake of an acute infection with the natural murine pathogen lymphocytic choriomeningitis virus become more resistant to apoptosis and acquire enhanced cytokine responsiveness without adjusting their homeostatic proliferation rates; concurrent metabolic adaptations promote increased CD8 T quiescence and fitness but also impart the reacquisition of a partial effector-like metabolic profile; and a gradual redistribution of aging CD8 T from blood and nonlymphoid tissues to lymphatic organs results in CD8 T accumulations in bone marrow, splenic white pulp, and, particularly, lymph nodes. Read More

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December 2018

Single limb immobilization model for bone loss from unloading.

J Biomech 2018 Dec 5. Epub 2018 Dec 5.

Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States. Electronic address:

Hindlimb suspension is the most used model for inducing bone loss from unloading but requires a separate ground control group. This control group cannot be used for genetic studies involving outbred mice. In this study, we evaluated a single limb immobilization (SLI) model for inducing bone loss from unloading, with the contralateral limb from the same animal used as a control. Read More

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December 2018

Implant-related sepsis in lower limb fractures following gunshot injuries in the civilian population: A systematic review.

Injury 2018 Dec 5. Epub 2018 Dec 5.

Division of Orthopaedics, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa; Countess of Chester Hospital, Chester, UK.

Introduction: The management of long bone lower limb fractures secondary to gunshot wounds (GSWs) in the civilian setting are complex and there is currently no consensus regarding the optimal approach to managing such fractures. This study aims to address the relationship of implant related sepsis in fractures secondary to GSWs.

Methods: A systematic review of the literature was performed on both Pubmed and Scopus databases that look at fractures caused by GSWs in the lower limb. Read More

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December 2018

Translational research on clinically failed zirconia implants.

Dent Mater 2018 Dec 11. Epub 2018 Dec 11.

HEPIA, University of Applied Sciences - Western Switzerland (HES-SO), Geneva, Switzerland. Electronic address:

Objectives: To provide fractographic analysis of clinically fractured zirconia implants recovered with their cemented crown. To calculate bending moments, corresponding stress and crack onset location on the implant's fracture surface using a mathematical model integrating spatial coordinates of the crown-implant part and occlusal loading obtained from 2D and 3D images.

Methods: 15 fractured zirconia implants parts (11 posterior and 4 anterior) with their all- ceramic crowns still cemented on it were recovered. Read More

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December 2018

Erythroid differentiation regulator 1 strengthens TCR signaling in thymocytes by modulating calcium flux.

Cell Immunol 2018 Dec 5. Epub 2018 Dec 5.

Institute of Convergence Science, Korea University, Anam-ro 145, Seongbuk-ku, Seoul 02841, Republic of Korea. Electronic address:

Erythroid differentiation regulator 1 (Erdr1) has been identified as a stromal survival factor released under stressful conditions. Previously, Erdr1 was reported to be expressed highly in thymus, but roles of Erdr1 in thymus were not known. Here, the effects of Erdr1 on T cell development were investigated. Read More

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December 2018

Pancreatic carcinoma underlying a complex presentation in late pregnancy: a case report.

J Med Case Rep 2018 Dec 15;12(1):369. Epub 2018 Dec 15.

Department of Maternal-Fetal Medicine Pregnancy Research Centre, Royal Women's Hospital, Parkville, Australia.

Background: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Read More

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December 2018

Corrective wedge ostectomy for an atypical femoral procurvatum deformity stabilised with a supracondylar bone plate.

J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e6. Epub 2018 Dec 5.

Translational Research and Animal Clinical Trial Study Group (TRACTS), U-Vet Veterinary Teaching Hospital, University of Melbourne.

Physeal fractures of the distal femur are among the most commonly encountered fractures in skeletally immature dogs. These fractures respond poorly to conservative management and thus early surgical reduction and stabilisation are recommended. A 7-month-old intact male Border collie presented with a history of chronic lameness. Read More

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December 2018

A Lateral Neck Myeloid Sarcoma Presenting as Acute Otitis Externa.

Arch Iran Med 2018 Nov 1;21(11):544-546. Epub 2018 Nov 1.

Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran.

Myeloid sarcoma (MS) is a solid extra-medullary tumor of immature myeloid cells which could occur before, during or after remission of acute leukemia at any site on the body. Owing to variation in differential diagnosis, pathologic evaluation and immunohistochemical staining are essential for definitive diagnosis. Rarely, MS has been shown as an isolated extramedullary relapse (iEMR) after allogeneic stem cell transplantation (allo-SCT), which often does not necessarily result in bone marrow involvement. Read More

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November 2018

Incidence, Costs and Predictors of Non-Union, Delayed Union and Mal-Union Following Long Bone Fracture.

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne VIC 3004, Australia.

Fracture healing complications are common and result in significant healthcare burden. The aim of this study was to determine the rate, costs and predictors of two-year readmission for surgical management of healing complications (delayed, mal, non-union) following fracture of the humerus, tibia or femur. Humeral, tibial and femoral (excluding proximal) fractures registered by the Victorian Orthopaedic Trauma Outcomes Registry over five years ( = 3962) were linked with population-level hospital admissions data to identify two-year readmissions for delayed, mal or non-union. Read More

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December 2018

Drug-Loaded Biomimetic Ceramics for Tissue Engineering.

Pharmaceutics 2018 Dec 13;10(4). Epub 2018 Dec 13.

Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

The mimesis of biological systems has been demonstrated to be an adequate approach to obtain tissue engineering scaffolds able to promote cell attachment, proliferation, and differentiation abilities similar to those of autologous tissues. Bioceramics are commonly used for this purpose due to their similarities to the mineral component of hard tissues as bone. Furthermore, biomimetic scaffolds are frequently loaded with diverse therapeutic molecules to enhance their biological performance, leading to final products with advanced functionalities. Read More

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December 2018

3D Imaging of Indentation Damage in Bone.

Materials (Basel) 2018 Dec 13;11(12). Epub 2018 Dec 13.

Henry Moseley X-ray Imaging Facility, Henry Royce Institute, School of Materials, The University of Manchester, Manchester M13 9PL, UK.

Bone is a complex material comprising high stiffness, but brittle, crystalline bio-apatite combined with compliant, but tough, collagen fibres. It can accommodate significant deformation, and the bone microstructure inhibits crack propagation such that micro-cracks can be quickly repaired. Catastrophic failure (bone fracture) is a major cause of morbidity, particularly in aging populations, either through a succession of small fractures or because a traumatic event is sufficiently large to overcome the individual crack blunting/shielding mechanisms. Read More

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December 2018

Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications.

Dent J (Basel) 2018 Dec 13;6(4). Epub 2018 Dec 13.

Tecnologica Research Institute, Stem Cells Unit, 88900 Crotone, Italy.

Tissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches. Oral tissues have been found to be rich in stem cells from different sources: Stem cells from oral cavity are easily harvestable and have shown a great plasticity towards the main lineages, specifically towards bone tissues. Dental pulp stem cells (DPSCs) are the most investigated mesenchymal stem cells (MSCs) from dental tissues, however, the oral cavity hosts several other stem cell lineages that have also been reported to be a good alternative in bone tissue engineering. Read More

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December 2018

ELK1-induced upregulation of long non-coding RNA MIR100HG predicts poor prognosis and promotes the progression of osteosarcoma by epigenetically silencing LATS1 and LATS2.

Biomed Pharmacother 2019 Jan 5;109:788-797. Epub 2018 Nov 5.

Zhejiang Chinese Medical University, No.548 Bingwen road, Bingjiang district, Hangzhou, Zhejiang province, 310053, China. Electronic address:

Osteosarcoma (OS) is the commonest malignant bone tumor in the world. High incidence of OS has gradually become a social problem. Recent years, numerous studies have revealed that long non-coding RNAs (lncRNAs) are crucial regulators in the tumor progression. Read More

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January 2019

Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives.

Biomed Pharmacother 2019 Jan 29;109:2318-2326. Epub 2018 Nov 29.

Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences University of Kragujevac, 69 Svetozar Markovic Street, 34000, Kragujevac, Serbia. Electronic address:

Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions, meniscal damage, and synovitis. Innate immune cells (natural killer cells, macrophages, and mast cells) play the most important pathogenic role in the early inflammatory response, while cells of adaptive immunity (CD4 + Th1 lymphocytes and antibody producing B cells) significantly contribute to the development of chronic, relapsing course of inflammation in OA patients. Conventional therapy for OA is directed toward symptomatic treatment, mainly pain management, and is not able to promote regeneration of degenerated cartilage or to attenuate joint inflammation. Read More

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January 2019

Protective effects of Acanthopanax senticosus - Ligustrum lucidum combination on bone marrow suppression induced by chemotherapy in mice.

Biomed Pharmacother 2019 Jan 26;109:2062-2069. Epub 2018 Nov 26.

College of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province, 130118, China. Electronic address:

This study investigated the combination effects of the Acanthopanax senticosus - Ligustrum lucidum (AS-LL) herb pair on bone marrow suppression caused by chemotherapy. A bone marrow suppression model was established by intraperitoneal injection (i.p. Read More

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January 2019

Nano-hydroxy apatite/chitosan/gelatin scaffolds enriched by a combination of platelet-rich plasma and fibrin glue enhance proliferation and differentiation of seeded human dental pulp stem cells.

Biomed Pharmacother 2019 Jan 26;109:1924-1931. Epub 2018 Nov 26.

Trauma Research Center, Aja University of Medical Science, Tehran, Iran. Electronic address:

The purpose of this study was to investigate the effects of Fibrin Glue (FG) and activated platelet-rich plasma (a-PRP) on the proliferation and osteogenic differentiation of human dental pulp stem cells (h-DPSCs). Therefore, we planned to investigate in vitro behavior of porous composite scaffolds based on chitosan-gelatin/nanohydroxyapatite (CS-G/nHA) treated with FG and a-PRP. The porous structure of CS-G/nHA was prepared using combination of particle leaching and freeze-drying methods. Read More

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January 2019

Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran.

Biomed Pharmacother 2019 Jan 26;109:1834-1840. Epub 2018 Nov 26.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune arthropathy characterized by synovial hyperplasia leading to functional impairment. Although the exact cause of RA is unknown, there is evidence suggesting the role of T cell subtypes in the pathogenesis of RA. Conventional therapy in some RA patients is associated with mild or severe side effects, and resistance of some patients has been reported to these types of therapy. Read More

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January 2019

Hsa_circRNA_33287 promotes the osteogenic differentiation of maxillary sinus membrane stem cells via miR-214-3p/Runx3.

Biomed Pharmacother 2019 Jan 20;109:1709-1717. Epub 2018 Nov 20.

Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-sen University & Guangdong Key Laboratory of Stomatology, Guangdong, China. Electronic address:

Background: Circular RNAs (circRNAs) comprise a novel class of noncoding RNAs that play important roles in a variety of diseases. However, the mechanism by which circRNAs regulate the osteogenic differentiation of maxillary sinus membrane stem cells (MSMSCs) remains largely unclear.

Methods: Microarray analysis was used to explore the expression profiles of circRNAs during the osteogenic differentiation of normal and BMP2 induced-MSMSCs. Read More

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January 2019

TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEK/ERK pathway.

Biomed Pharmacother 2019 Jan 16;109:1640-1649. Epub 2018 Nov 16.

Department of Pediatric Internal Medicine, Cangzhou Central Hospital, Xihuan Middle Street, Yunhe District, Cangzhou city, Hebei Province 061000, China.

Acute lymphoblastic leukemia (ALL) is characterized by abnormal lymphoblasts accumulation in the bone marrow and blood. Despite great efforts have been made in exploring novel therapeutic method, the prognosis of children with ALL is still unsatisfied. Glucocorticoid (GC) resistance is a great obstacle for the clinical treatment of ALL. Read More

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January 2019

Metformin; an old antidiabetic drug with new potentials in bone disorders.

Biomed Pharmacother 2019 Jan 26;109:1593-1601. Epub 2018 Nov 26.

Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:

The prevalence of diabetes mellitus especially type 2 diabetes mellitus is increasing all over the world. In addition to cardiomyopathy and nephropathy, diabetics are at higher risk of mortality and morbidity due to greater risk of bone fractures and skeletal abnormalities. Patients with diabetes mellitus have lower bone quality in comparison to their non-diabetic counterparts mainly because of hyperglycemia, toxic effects of advanced glycosylation end-products (AGEs) on bone tissue, and impaired bone microvascular system. Read More

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January 2019

Downregulation of long noncoding RNA HOTAIRM1 variant 1 contributes to osteoarthritis via regulating miR-125b/BMPR2 axis and activating JNK/MAPK/ERK pathway.

Biomed Pharmacother 2019 Jan 14;109:1569-1577. Epub 2018 Nov 14.

Department of Orthopaedic Surgery, Tianjin Hospital, Hexi, Tianjin, 300211, China.

Objective: Osteoarthritis (OA) is a leading cause of pain and disability worldwide, which is characterized by degenerative and inflammatory processes affecting joints and surrounding tissues. This study aimed to elucidate the role and possible mechanism of long non-coding RNA HOX antisense intergenic RNA myeloid 1 variant 1 (HOTAIRM1-1) in the development of osteoarthritis (OA).

Material And Methods: The expressions of HOTAIRM1-1 and miR-125b in OA cartilages and normal articular cartilages were determined. Read More

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January 2019

Vitamin D and liver fibrosis: Molecular mechanisms and clinical studies.

Biomed Pharmacother 2019 Jan 10;109:1351-1360. Epub 2018 Nov 10.

Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand. Electronic address:

Vitamin D plays a primary role in regulation of bone metabolism and calcium homeostasis. Interestingly, emerging evidence suggests protective effects of vitamin D against liver fibrogenesis. However, the precise mechanisms of this action remain mysterious. Read More

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January 2019

Curcumin pretreatment protects against hypoxia/reoxgenation injury via improvement of mitochondrial function, destabilization of HIF-1α and activation of Epac1-Akt pathway in rat bone marrow mesenchymal stem cells.

Biomed Pharmacother 2019 Jan 9;109:1268-1275. Epub 2018 Nov 9.

Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address:

Bone marrow mesenchymal stem cells (BMSCs) possess promising therapeutic effects and have been considered as a highly desirable agent for tissue injury treatment. However, little survived cells after transplanting due to severe relocated conditions (characterized by prolonged hypoxia and oxidative stress) lead to hampered benefits of BMSCs-based cell therapy. Curcumin, a natural dietary product, has attracted increasing attention owing to its profound pharmacologic properties. Read More

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January 2019

Effect of FGF-21 on implant bone defects through hepatocyte growth factor (HGF)-mediated PI3K/AKT signaling pathway.

Biomed Pharmacother 2019 Jan 9;109:1259-1267. Epub 2018 Nov 9.

Department of Dental Implant, Stomatological Hospital of Chongqing Medical University, Chongqing, 400015, China. Electronic address:

Implant bone defects are the most common phenomenon in the processes of bone transplantation. Evidences have identified that fibroblast growth factor-21 (FGF-21) encourages osteogenesis for patients with implant bone defects. The purpose of this study was to investigate the role of FGF-21 and its potential mechanism in bone mesenchymal stem cells (BMSCs). Read More

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January 2019

Overexpression of CXCR7 promotes mesenchymal stem cells to repair phosgene-induced acute lung injury in rats.

Biomed Pharmacother 2019 Jan 7;109:1233-1239. Epub 2018 Nov 7.

Center of Emergency & Intensive Care Unit, Jinshan Hospital, Fudan University, Shanghai 201508, China; Medical Center of Chemical Injury, Jinshan Hospital, Fudan University, Shanghai 201508, China; Medical Research Center for Chemical Injury, Emergency and Critical Care of Chemical Injury, Jinshan Hospital, Fudan University, Shanghai 201508, China. Electronic address:

Phosgene exposure may result in acute lung injury (ALI) with high mortality. Emerging evidence suggests that mesenchymal stem cells (MSCs) have a therapeutic potential against ALI. CXC chemokine receptor 7 (CXCR7) has been identified as a receptor of stromal-cell-derived factor 1 (SDF1) involved in MSC migration and may be an important mediator of the therapeutic effects of MSCs on ALI. Read More

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January 2019

MiR-217 promotes cell proliferation and osteogenic differentiation of BMSCs by targeting DKK1 in steroid-associated osteonecrosis.

Biomed Pharmacother 2019 Jan 6;109:1112-1119. Epub 2018 Nov 6.

Department of Orthopedics, Renmin Hospital, Wuhan University, Wuhan, Hubei, China; Department of Orthopedics, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

MicroRNAs (miRNAs) have recently been recognized to play an important role in bone-associated diseases. This study aims to explore the expression profile and biological function of miR-217, which is known to be related to tumor cell proliferation and migration, to the proliferation and osteogenic differentiation of MSCs from the patients with steroid-associated osteonecrosis (ONFH). Bone marrow was obtained from the proximal femur of 10 patients with ONFH and 10 patients with femoral neck fractures. Read More

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January 2019

Tetramethylpyrazine (TMP) ameliorates corneal neovascularization via regulating cell infiltration into cornea after alkali burn.

Biomed Pharmacother 2019 Jan 6;109:1041-1051. Epub 2018 Nov 6.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

In the present study, we investigated the underlying mechanism of tetramethylpyrazine (TMP)-medicated inhibition of corneal neovascularization (CNV). Our data showed that TMP could effectively downregulate the expression levels of CXCR4 mRNA and protein, as well as inhibit HUVECs, endothelial cells, tubule formation in vitro. In vivo, alkali burn (1 M NaOH) could remarkably upregulate CXCR4 expression and increase the migration of TNF-α-positive cells to corneal stroma. Read More

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January 2019

Surface-immobilized plant-derived osteopontin as an effective platform to promote osteoblast adhesion and differentiation.

Colloids Surf B Biointerfaces 2019 Jan 15;173:816-824. Epub 2018 Oct 15.

Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok, 10330, Thailand; Center of Excellence in Materials and Bio-interfaces, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok, 10330, Thailand. Electronic address:

In this report, recombinant human osteopontin synthesized in tobacco plants (p-rhOPN) is introduced as a potential bioactive molecule that can promote osteoblast adhesion and differentiation. A glass substrate (SiO/Si-OH) grafted with poly(acrylic acid) (SiO/Si-PAA) was prepared by surface-initiated reversible addition-fragmentation chain transfer polymerization and used as a carboxyl-rich platform for the chemical conjugation of p-rhOPN. The PAA grafting and subsequent p-rhOPN immobilization were confirmed by water contact angle, Fourier transform-infrared spectroscopy, X-ray photoelectron spectroscopy and atomic force microscopy analyses. Read More

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January 2019

Preventive Effects of Resveratrol-enriched Extract of Peanut Sprout on Bacteria- and Estradiol-induced Prostatitis in Mice.

Nat Prod Commun 2017 Jan;12(1):73-78

The present study investigated the effect of peanut sprout extract (PSE) as a natural resveratrol supplement on chronic bacterial prostatitis (CBP) and estradiol- induced benign prostatic hyperplasia (BPH). PSE contained a high level of resveratrol (148.51 ± 3. Read More

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January 2017

Oral Radiographic Evidence of Secondary Hyperparathyroidism in an End-Stage Renal Failure Patient: A Case Report.

Northwest Dent 2017 Mar;96(2):33-37

Background: The authors report a case of a 42-year-old woman with End Stage Renal Disease (ESRD) undergoing dialysis therapy with the relative loss of tooth root lamina dura and several mandibular radiolucencies. Secondary hyperparathyroidism related to End Stage Renal Disease may result in the loss of bone density and radiolucent lesions, which has been previously described as Brown tumor. Findings significant for hyperparathyroidism may befound on routine dental imaging. Read More

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Cone Beam Computed Tomography of mandibular bone density in non-diabetic vs. diabetic populations.

Tex Dent J 2016 Jul;133(7):414-422

Background: The successful placement of dental implant largely depends on the properties of alveolar bone at the recipient site. Systemic conditions such as diabetes mellitus could impair bone quality and compromise implant treatment. However, limited information in this area exists so far. Read More

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[Acetabular Revision: Reconstruction of Cavitary and Segmental Defects with Special Consideration of Modular Highly Porous Acetabular Revision Systems].

Z Orthop Unfall 2018 Dec 14;156(6):692-703. Epub 2018 Dec 14.

Klinik für Orthopädie, Universitätsklinikum Ulm.

Due to the increasing number of primary hip arthroplasty procedures, revision surgery will be an increasing challenge. The surgeon is frequently confronted with important acetabular defects. Careful preoperative planning is essential to achieve functional and long-term success. Read More

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December 2018

Prognosis of renal cell carcinoma with bone metastases: Experience from a large cancer centre.

Eur J Cancer 2018 Dec 11;107:79-85. Epub 2018 Dec 11.

Department of Cancer Medicine, Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France.

Background: Bone metastases (BMs) are associated with significant morbidity and shorter survival in renal cell carcinoma (RCC). Our purpose was to identify prognostic factors for overall survival (OS) in RCC patients with BMs.

Methods: Data from patients with BMs from RCC treated at Gustave Roussy between April 1992 and March 2016 were retrospectively collected. Read More

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December 2018
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