20,013 results match your criteria Bone Marrow Transplantation Long-Term Effects


Stem Cell Mobilization and Autograft Minimal Residual Disease Negativity 1 with Novel Induction Regimens in Multiple Myeloma.

Biol Blood Marrow Transplant 2020 May 19. Epub 2020 May 19.

Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York; The Rockefeller University, New York, New York. Electronic address:

Autologous stem cell transplantation (ASCT) remains the standard-of-care for transplant-eligible multiple myeloma (MM) patients. Bortezomib with lenalidomide and dexamethasone (VRD) is the most common triplet regimen for newly diagnosed MM in the US. Carfilzomib with lenalidomide and dexamethasone (KRD) has promising efficacy and may supplant VRD. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.04.011DOI Listing

Absence of damaging effects of stem cell donation in unrelated donors assessed by FISH and gene variance screening.

Bone Marrow Transplant 2020 May 21. Epub 2020 May 21.

Anthony Nolan Research Institute, The Royal Free Hospital, Pond Street, London, NW3 2QG, UK.

Astract: Granulocyte-Colony-Stimulating factor (G-CSF) is currently the standard mobilising agent for peripheral blood stem cell (PBSC) donation. Concerns that it may trigger chromosome aberrations similar to those observed in leukaemia patients were refuted but long-term effects of G-CSF mobilisation on genome integrity remains unclear. In the setting of a multi-centre clinical trial we screened blood samples from 50 PBSC donors at cellular and gene level for aberrations common in haematological malignancies using fluorescence in situ hybridisation (FISH) and next generation sequencing (NGS) assays. Read More

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http://dx.doi.org/10.1038/s41409-020-0945-yDOI Listing

Quality of Life Trajectories in Adolescent and Young Adult Versus Older Adult Allogeneic Hematopoietic Cell Transplantation Recipients.

Biol Blood Marrow Transplant 2020 May 18. Epub 2020 May 18.

Department of Pediatric Hematology Oncology and Bone Marrow Transplant, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Hematopoietic Cell Transplantation (HCT) is physically and psychologically challenging, potentially exposing patients to Quality of Life (QoL) impairments. Adolescent and Young Adults (AYAs aged 15-39) are a vulnerable cohort facing multiple hurdles due to dynamic changes in several aspects of their lives. The AYA population may be particularly prone to QoL issues during HCT. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.03.023DOI Listing

Pregnancy and lactation, a challenge for the skeleton.

Endocr Connect 2020 May 1. Epub 2020 May 1.

N Bonnet , Department of Musculoskeletal health, Nestlé Research, Innovation EPFL Park, Lausanne, Switzerland.

In this review we discuss skeletal adaptations to the demanding situation of pregnancy and lactation. Calcium demands are increased during pregnancy and lactation, and this is effectuated by a complex series of hormonal changes. The changes in bone structure at the tissue and whole bone level observed during pregnancy and lactation appear to largely recover over time. Read More

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http://dx.doi.org/10.1530/EC-20-0055DOI Listing

Extramedullary leukemia relapse after allogeneic stem cell transplantation: a novel mechanism of immune escape?

Immunotherapy 2020 May 21. Epub 2020 May 21.

2 Department of Internal Medicine, Propaedeutic, ATTIKON General University Hospital, National & Kapodistrian University of Athens.

Relapse is a significant cause of treatment failure after allogeneic stem cell transplantation. In many cases relapse occurs when leukemic cells escape from immune surveillance. In the setting of haploidentical transplantation, immune escape is usually the result of the loss of the mismatched haplotype from leukemic cells, while downregulation of HLA-expression has been postulated as a significant cause of immune escape after transplantation with the use of HLA-matched donors. Read More

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http://dx.doi.org/10.2217/imt-2019-0215DOI Listing

A novel strategy for the prevention of HBV-related hepatitis following allogeneic hematopoietic stem cell transplantation from HBsAg-positive donors lantation from HBsAg-positive donors.

Biol Blood Marrow Transplant 2020 May 17. Epub 2020 May 17.

Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China; Institute of Hematology, Zhejiang University, Hangzhou, People's Republic of China. Electronic address:

Background: Hematopoietic stem cell transplantation (HSCT) is increasingly being applied globally. Cases in which healthy HSCT donors are chronically infected with HBV are relatively common in areas where HBV is endemic. Recipients of stem cells from such HBsAg-positive donors are at risk of viral infection, and hence may develop HBV-related hepatitis. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.05.004DOI Listing

Anti-CS1 × Anti-CD3 Bispecific Antibody (BiAb)-Armed Anti-CD3 Activated T Cells (CS1-BATs) Kill CS1 Myeloma Cells and Release Type-1 Cytokines.

Front Oncol 2020 5;10:544. Epub 2020 May 5.

Division of Hematology and Oncology, Bone Marrow Transplantation and Department of Medicine, University of Virginia Cancer Center, Charlottesville, VA, United States.

Multiple myeloma (MM) remains incurable despite advances in chemotherapy, targeted therapies, and immunotherapy. Bispecific antibody (BiAb)-armed activated T cells (BATs) have been developed for targeting and treatment of solid and hematologic malignancies. BATs are serial killers of tumor cells, secrete Th cytokines, and induce adaptive cellular and humoral immune responses in patients (pts). Read More

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http://dx.doi.org/10.3389/fonc.2020.00544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214537PMC

Pre-transplant thrombocytopenia predicts engraftment time and blood products requirement in allogeneic hematopoietic stem cell transplantation patients.

Transfus Apher Sci 2020 May 13:102810. Epub 2020 May 13.

Department of Hematology, Tarbiat Modares University, Tehran, Iran. Electronic address:

Introduction: Thrombocytopenia is a common consequence of leukemia that affects the outcome of hematopoietic stem cell transplantation (HSCT). The stromal damage of bone marrow following pre-HSCT conditioning regimens can delay the hematopoietic engraftment and increased blood product transfusions. We tried to define threshold based on pre-transplant platelet count as a biomarker to predict engraftment time and blood product requirements in allogeneic HSCT patients. Read More

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http://dx.doi.org/10.1016/j.transci.2020.102810DOI Listing

The Expression of P53, MDM2, c-myc, and P14 Genes in Newly Diagnosed Acute Lymphoblastic Leukemia Patients.

Indian J Hematol Blood Transfus 2020 Apr 16;36(2):277-283. Epub 2019 Oct 16.

1Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The treatment response of acute lymphoblastic leukemia (ALL) depends on the percentage of lymphoblasts, cytogenetic aberrations, and altered gene expression. The analysis of the gene expression is applicable for determination of risk stratification and prognosis of cancers. c-MYC, P14, MDM2, and P53 play a vital role in cell survival through a functional network. Read More

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http://dx.doi.org/10.1007/s12288-019-01214-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229094PMC

Restoration of estrous cycles by co-transplantation of mouse ovarian tissue with MSCs.

Cell Tissue Res 2020 May 19. Epub 2020 May 19.

Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

This study investigates the effect of bone marrow (BM-MSCs) and visceral peritoneum (VP-MSCs)-derived mesenchymal stem cells on the transplanted ovary. VP-MSCs and BM-MSCs were obtained from green fluorescent protein-expressing mice (GFP). Six- to eight-week-old female NMRI mice were divided into four experimental groups, autograft ovarian tissue fragments (AO), autograft ovarian tissue fragments encapsulated in fibrin-collagen hydrogel (AO-H), autograft ovarian tissue fragments encapsulated in fibrin-collagen hydrogel containing BM-MSCs (AO-HB) and autograft ovarian tissue fragments encapsulated in fibrin-collagen hydrogel containing VP-MSCs (AO-HP). Read More

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http://dx.doi.org/10.1007/s00441-020-03204-xDOI Listing

Prognostic Role of Beta-2 Microglobulin in Patients with Light Chain Amyloidosis Treated with Autologous Stem Cell Transplantation.

Biol Blood Marrow Transplant 2020 May 15. Epub 2020 May 15.

Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester. Electronic address:

Background: The prognostic impact of increased beta-2 microglobulin (B2M) in patients with light chain (AL) amyloidosis undergoing autologous stem cell transplantation (ASCT) is unknown. The Mayo 2012 stage and increased bone marrow plasma cell (BMPC) percentage are known predictors for survival. Increased beta-2 microglobulin (B2M) predicts survival in patients with multiple myeloma. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.04.024DOI Listing

Building a hematopoietic cell transplantation outcomes registry in Mexico.

Bone Marrow Transplant 2020 May 16. Epub 2020 May 16.

Hematology Service, Unidad Médica de Alta Especialidad "Manuel Avila Camacho", Instituto Mexicano del Seguro Social, Puebla, PL, Mexico.

The aim of this study was to assess the feasibility of hematopoietic cell transplantation (HCT) data collection using an electronic platform at Mexican centers. Four public centers performing HCT in adults were included. A cloud-based electronic platform in Spanish was developed to allow real-time registration of demographic, clinical, and outcomes variables. Read More

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http://dx.doi.org/10.1038/s41409-020-0944-zDOI Listing

Changes in patients population and characteristics of hematopoietic stem cell transplantation for relapsed/refractory Hodgkin lymphoma: an analysis of the Lymphoma Working Party of the EBMT.

Bone Marrow Transplant 2020 May 15. Epub 2020 May 15.

Department of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.

Indications for autologous (auto-HCT) and allogeneic transplantation (allo-HCT) in relapsed/refractory Hodgkin lymphoma (rrHL) have been long established. The expectation is that long-term outcomes have significantly improved over time with increased experience in these procedures. The objective of this study was to assess whether this is the case and to identify further areas of improvement. Read More

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http://dx.doi.org/10.1038/s41409-020-0929-yDOI Listing

Predicting the availability of haematopoietic stem cell donors using machine learning.

Biol Blood Marrow Transplant 2020 May 12. Epub 2020 May 12.

Department of Specialist Patient Services, NHS Blood and Transplant, UK.

Haematopoietic stem cell transplantation (HSCT) is firmly established as an important curative therapy for patients with hematologic malignancies and other blood disorders. Apart from finding human leukocyte antigen (HLA) matched donors during the HSCT process, donor availability remains a key consideration as the time taken from diagnosis to transplant is recognised to adversely affect patient outcome. In this study, we aimed to develop and validate a machine learning approach to predict the availability of stem cell donors. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.03.026DOI Listing
May 2020
3.404 Impact Factor

Morbidity burden in survivors of multiple myeloma who underwent autologous transplantation: A Bone Marrow Transplantation Survivor Study.

Cancer 2020 May 15. Epub 2020 May 15.

Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Autologous blood or bone marrow transplantation (aBMT) is considered the standard of care for patients with multiple myeloma (MM). Significantly improved survival necessitates an understanding of the morbidity burden borne by the growing survivor population.

Methods: The authors evaluated severe and/or life-threatening chronic health conditions (CHCs) and subsequent neoplasms (SNs) in patients with MM who were treated with aBMT using the Bone Marrow Transplant Survivor Study. Read More

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http://dx.doi.org/10.1002/cncr.32941DOI Listing

Peripheral Blood Stem Cell Harvest HPC Count Is an Effective Surrogate Marker for CD34+ Cell Count in Allogeneic Stem Cell Transplant Setting.

Transl Oncol 2020 May 11;13(7):100788. Epub 2020 May 11.

Clinical Haematology, National Institute of Blood Disease and Bone Marrow Transplantation, ST, 2/A Block 17 Gulshan-e-Iqbal KDA Scheme 24, Karachi, 75300, Pakistan; Bone Marrow Transplantation, National Institute of Blood Disease and Bone Marrow Transplantation, ST, 2/A Block 17 Gulshan-e-Iqbal KDA Scheme 24, Karachi, 75300, Pakistan. Electronic address:

Objective: We assessed the predictive potential of XN-HPC for CD34+ cell count as obtained through Sysmex automated hematology analyzers (XN-1000).

Methods: This study was conducted at the National Institute of Blood Diseases and Bone Marrow Transplantation in 84 donors between December 2012 and December 2017 in the first phase and later validated in 112 donors between December 2017 and December 2018. Sysmex XN-1000 and BD FACS Calibur estimated XN-HPC and CD34+ cells of peripheral blood apheresis product, respectively. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218209PMC

Does Desire to Pursue Pleasurable Activities Matter? The Impact of Pre-transplant Anhedonia on Quality of Life and Fatigue in Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2020 May 11. Epub 2020 May 11.

Harvard Medical School, Boston, MA; Massachusetts General Hospital Cancer Center, Boston, MA.

Background: Anhedonia, the loss of the capacity to experience pleasure, is subjectively and biologically distinct from depressed mood. Few studies have specifically examined the association of pre-transplant anhedonia with key functional outcomes (e.g. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.04.014DOI Listing

A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem Progenitor Cells (HSPCs).

Stem Cell Rev Rep 2020 May 14. Epub 2020 May 14.

Center for Preclinical Studies and Technology, Department of Regenerative Medicine, Medical University of Warsaw, Warsaw, Poland.

Delayed homing and engraftment of hematopoietic stem progenitor cells (HSPCs) or even failure to engraft at all is significant clinical problem after hematopoietic transplant. Therefore, in order to develop more efficient homing and engraftment facilitating strategies it is important to learn more about this process. Our team has postulated that myeloablative conditioning for transplantation induces in bone marrow (BM) microenvironment a state of sterile inflammation in which elements of innate immunity activated by radio- or chemotherapy conditioning for transplant play an important role. Read More

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http://dx.doi.org/10.1007/s12015-020-09983-8DOI Listing

Gut microbiota composition influences outcomes of skeletal muscle nutritional intervention via blended protein supplementation in posttransplant patients with hematological malignancies.

Clin Nutr 2020 Apr 29. Epub 2020 Apr 29.

Institute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Beijing, China. Electronic address:

Background: Skeletal muscle atrophy is an important and independent predictor of survival after hematopoietic stem cell transplantation (HSCT). Our previous study found that soy-whey blended protein (SWP) can improve muscle mass in acute leukemia patients.

Objective: We aimed to explore potential factors that influence muscle outcomes after nutritional intervention. Read More

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http://dx.doi.org/10.1016/j.clnu.2020.04.030DOI Listing

Deletion of inflammasome adaptor protein ASC enhances functional recovery after spinal cord injury in mice.

J Orthop Sci 2020 May 10. Epub 2020 May 10.

Department of Orthopaedics, Jichi Medical University School of Medicine, Tochigi, 329-0498, Japan.

Background: Research has revealed the crucial roles of inflammasomes in various central nervous system disorders. However, the role of inflammasomes in secondary damage following spinal cord injury (SCI) remains incompletely understood.

Methods: Here, we investigated the role of apoptosis-associated speck-like protein (ASC), an adaptor protein for inflammasome formation, after contusion SCI in ASC homozygous knockout (ASC) mice. Read More

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http://dx.doi.org/10.1016/j.jos.2020.04.006DOI Listing

Toxic epidermal necrolysis syndrome induced by tigecycline: a case report.

J Int Med Res 2020 May;48(5):300060520922416

Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.

A 56-year-old man diagnosed with non-Hodgkin's lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that improved after treatment with anti-allergy drugs and steroids. Read More

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http://dx.doi.org/10.1177/0300060520922416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223212PMC

Introduction of new pediatric EBMT criteria for VOD diagnosis: is it time-saving or money-wasting? : Prospective evaluation of pediatric EBMT criteria for VOD.

Bone Marrow Transplant 2020 May 12. Epub 2020 May 12.

Department of Pediatric Hematology/Oncology and BMT, Wroclaw Medical University, Supraregional Center of Pediatric Oncology "Cape of Hope", Wrocław, Poland.

Hepatic veno-occlusive disease (VOD) is a potentially fatal complication following hematopoietic stem cell transplantation (HSCT). We evaluated in prospective analysis the usefulness of the pediatric EBMT criteria for VOD diagnosis and their presumable impact on cost effectiveness and patients' outcome. Study included all 282 HSCT procedures performed in Department of Pediatric Hematology/Oncology and BMT in Wrocław between January 2016 and March 2019. Read More

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http://dx.doi.org/10.1038/s41409-020-0918-1DOI Listing

In-vivo differentiation of adult hematopoietic stem cells from a single-cell point of view.

Curr Opin Hematol 2020 May 7. Epub 2020 May 7.

INSERM Unit 1218 ACTION, University of Bordeaux, Bergonié Cancer Institute, Bordeaux, France.

Purpose Of Review: Although hematopoietic stem cell (HSC) function has long been studied by transplantation assays, this does not reflect what HSCs actually do in their native context. Here, we review recent technologic advances that facilitate the study of HSCs in their native context focusing on inducible HSC-specific lineage tracing and inference of hematopoietic trajectories through single-cell RNA sequencing (scRNA-Seq).

Recent Findings: Lineage tracing of HSCs at the population level using multiple systems has suggested that HSCs make a major contribution to steady-state hematopoiesis. Read More

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http://dx.doi.org/10.1097/MOH.0000000000000587DOI Listing

The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.

Int J Mol Sci 2020 May 9;21(9). Epub 2020 May 9.

Transplantation Immunobiology, School of Biology and Biotechnology, Institute of Molecular Biology, Genomics and Proteomics, University of Leon, 24071 Leon, Spain.

Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote peripheral Tregs expansion and sustain their survival. Read More

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http://dx.doi.org/10.3390/ijms21093347DOI Listing

Understanding the Barriers to Pediatric Oncologist Engagement and Accrual to Clinical Trials in National Cancer Institute-Designated Community Oncology Research Programs.

JCO Oncol Pract 2020 May 12:JOP1900707. Epub 2020 May 12.

Department of Pediatrics, Division of Hematology/Oncology, The University of Texas Health San Antonio, San Antonio, TX.

Purpose: Clinical trial participation leads to progress in cancer care. Principal investigators (PIs) and clinical research associates (CRAs) play key roles in the provision and maintenance of clinical trial portfolios at their sites. Previous studies have evaluated the educational and resource needs of adult oncology providers, but nothing to date has focused on providers of pediatric oncology care. Read More

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http://dx.doi.org/10.1200/JOP.19.00707DOI Listing

Pathogenicity of BK virus on the urinary system.

Cent European J Urol 2020 27;73(1):94-103. Epub 2020 Feb 27.

Department of Vascular, General and Transplantation Surgery, Wrocław Medical University, Wrocław, Poland.

Introduction: The polyomaviruses are omnipresent in nature. The major sites of BK virus appearance are the kidney tubular epithelial cells and urinary bladder surface transitional cells.

Material And Methods: A literature search according to PRISMA guidelines within the Medline database was conducted in July 2019 for articles presenting data about BK virus in urologic aspect without setting time limits, using the terms 'BK virus' in conjunction with transplantation, nephropathy, stenosis, cancer, bladder, prostate, kidney. Read More

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http://dx.doi.org/10.5173/ceju.2020.0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203775PMC
February 2020

Low toxicity and favorable overall survival in relapsed/refractory B-ALL following CAR T cells and CD34-selected T-cell depleted allogeneic hematopoietic cell transplant.

Bone Marrow Transplant 2020 May 10. Epub 2020 May 10.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

To define the tolerability and outcome of allogeneic hematopoietic stem cell transplant (allo-HSCT) following CAR T-cell therapy, we retrospectively reviewed pediatric/young adult patients with relapsed/refractory B-ALL who underwent this treatment. Fifteen patients (median age 13 years; range 1-20 years) with a median potential follow-up of 39 months demonstrated 24-month cumulative incidence of relapse, cumulative incidence of TRM, and OS of 16% (95% CI: 0-37%), 20% (95% CI: 0-40%), and 80% (95% CI: 60-100%), respectively. Severe toxicity following CAR T cells did not impact OS (p = 0. Read More

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http://dx.doi.org/10.1038/s41409-020-0926-1DOI Listing

Short-term regulation of hematopoiesis by lipoprotein(a) results in the production of pro-inflammatory monocytes.

Int J Cardiol 2020 May 7. Epub 2020 May 7.

Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; Department of Internal Medicine, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands; Department of Hematology, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands. Electronic address:

Background: Lipoproteins are important regulators of hematopoietic stem and progenitor cell (HSPC) biology, predominantly affecting myelopoiesis. Since myeloid cells, including monocytes and macrophages, promote the inflammatory response that propagates atherosclerosis, it is of interest whether the atherogenic low-density lipoprotein (LDL)-like particle lipoprotein(a) [Lp(a)] contributes to atherogenesis via stimulating myelopoiesis.

Methods & Results: To assess the effects of Lp(a)-priming on long-term HSPC behavior we transplanted BM of Lp(a) transgenic mice, that had been exposed to elevated levels of Lp(a), into lethally-irradiated C57Bl6 mice and hematopoietic reconstitution was analyzed. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.05.008DOI Listing

Epidemiologic Characteristics of Acute Kidney Injury During Cisplatin Infusions in Children Treated for Cancer.

JAMA Netw Open 2020 May 1;3(5):e203639. Epub 2020 May 1.

Peter Gilgan Centre For Research and Learning, Toronto, Ontario, Canada.

Importance: Few multicenter pediatric studies have comprehensively described the epidemiologic characteristics of cisplatin-associated acute kidney injury using standardized definitions.

Objective: To examine the rate of and risk factors associated with acute kidney injury among children receiving cisplatin infusions.

Design, Setting, And Participants: This prospective cohort study examined children (aged <18 years) recruited from May 23, 2013, to March 31, 2017, at 12 Canadian pediatric academic health centers who were receiving 1 or more cisplatin infusion. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.3639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210480PMC

Bone marrow mesenchymal stem cells improve bone erosion in collagen-induced arthritis by inhibiting osteoclasia-related factors and differentiating into chondrocytes.

Stem Cell Res Ther 2020 May 7;11(1):171. Epub 2020 May 7.

Department of Rheumatology, Shanxi Bethune Hospital, Taiyuan, 030032, Shanxi, China.

Background: Rheumatoid arthritis (RA) is characterized by joint inflammation and damage to the cartilage and bone in collagen-induced arthritis (CIA). Mesenchymal stem cells (MSCs) can improve articular symptoms and reduce bone erosion in CIA rats; however, the underlying mechanism remains unknown. This study aimed to investigate the mechanism underlying MSC-induced improvement of bone destruction in CIA. Read More

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http://dx.doi.org/10.1186/s13287-020-01684-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203805PMC

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis.

N Engl J Med 2020 05;382(19):1811-1822

From the Department of Pediatrics, Sapienza, University of Rome (F.L.), and the Department of Pediatric Hematology-Oncology (F.L.) and Division of Rheumatology (F.D.B.), IRCCS Bambino Gesù Children's Hospital, Rome, Pediatric Hematology-Oncology, Woman and Child Hospital, Azienda Ospedaliera Universitaria Integrata, Verona (S.C.), the Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, Monza Brianza per il Bambino e la sua Mamma Foundation, Monza (C.R.), the Clinic of Pediatric Hematology-Oncology, University Hospital of Padova, Padua (M.-C.P.), and the Division of Pediatric Onco-Hematology, Regina Margherita Hospital, Turin (F.F.) - all in Italy; the Divisions of Immunobiology and Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics (M.B.J.), and the Division of Rheumatology (A.G.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (M.B.J.) - all in Cincinnati; the Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston (C.A.); the Department of Hematology, Great Ormond Street Hospital for Children, London (A.R.); the Department of Pediatric Hematology-Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston (B.D.); the Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora (T.P.G.); the Departments of Pediatric Hematology-Oncology and Hematology and Oncology, Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús, Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid (J.S.), and the Department of Pediatric Hematology and Oncology, Hospital Universitari Vall d'Hebron, Barcelona (J.-L.D.D.); the Department of Pediatric Hematology and Oncology, University Children's Hospital, Muenster, Germany (M.A.); the Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ (M.H.); NovImmune, Plan-les-Ouates, Switzerland (G.L., M.B., C.M.); and MnS Modelling and Simulation, Dinant, Belgium (P.J.).

Background: Primary hemophagocytic lymphohistiocytosis is a rare syndrome characterized by immune dysregulation and hyperinflammation. It typically manifests in infancy and is associated with high mortality.

Methods: We investigated the efficacy and safety of emapalumab (a human anti-interferon-γ antibody), administered with dexamethasone, in an open-label, single-group, phase 2-3 study involving patients who had received conventional therapy before enrollment (previously treated patients) and previously untreated patients who were 18 years of age or younger and had primary hemophagocytic lymphohistiocytosis. Read More

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http://dx.doi.org/10.1056/NEJMoa1911326DOI Listing

Cold agglutinin disease revisited: A multinational, observational study of 232 patients.

Blood 2020 May 6. Epub 2020 May 6.

KG Jebsen Centre for B-cell Malignancies, Institute of Clinical Medicine, University of Oslo, Norway.

We retrospectively studied 232 patients with cold agglutinin disease (CAD) at 24 centers in five countries. In Norway and a northern region of Italy, the study was close to being population-based. For the first time, we demonstrate 4-fold differences between cold and warmer climates regarding prevalence (20 versus 5 cases/million) and incidence (1. Read More

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http://dx.doi.org/10.1182/blood.2020005674DOI Listing

Adenovirus viral kinetics and mortality in ex-vivo T-cell depleted hematopoietic cell transplant recipients with adenovirus infection from a single center.

J Infect Dis 2020 May 6. Epub 2020 May 6.

Infectious Diseases Service, Department of Medicine.

Background: We report on predictors of ADV viremia and correlation of ADV viral kinetics with mortality in ex-vivo T-cell depleted (TCD) HCT.

Methods: TCD HCT recipients from 1/1/2012 through 9/30/2018 were prospectively monitored for ADV in the plasma through Day (D)+100 post-transplant or for 16 weeks after the onset of ADV viremia. ADV viremia was defined as ≥2 consecutive viral loads (VL) ≥1000 copies/mL through D+100. Read More

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http://dx.doi.org/10.1093/infdis/jiaa237DOI Listing
May 2020
5.997 Impact Factor

Functional variations between Mesenchymal Stem Cells of different tissue origins: A comparative gene expression profiling.

Biotechnol Lett 2020 May 5. Epub 2020 May 5.

Hepato-Pancreato-Biliary Centre for Surgery & Transplantation, MIOT International, Chennai, Tamilnadu, India.

Background: Mesenchymal Stem Cells (MSCs), regardless of the tissue sources, are considered as excellent candidates for cellular therapy as they are immune-privileged cells containing a multitude of therapeutic functions that aid in tissue regeneration and repair. For the effective application of these cells in cell therapy, it is important to understand and characterize their biological functions.

Objectives: The present study attempts to characterize the variations in multipotent function such as cell surface antigen levels, proliferation, differentiation and stemness (pluripotency) potential of MSCs isolated from foetal [wharton's jelly (WJ), foetal and maternal side of placenta (PF and PM)] and adult tissue sources [bone marrow (BM) and adipose tissue (AT)] using gene expression by real time PCR (qRT-PCR). Read More

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http://dx.doi.org/10.1007/s10529-020-02898-xDOI Listing

Conditions for combining gene therapy with bone marrow transplantation in murine Krabbe disease.

Bioimpacts 2020 24;10(2):105-115. Epub 2020 Mar 24.

Department of Neurology, Sidney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Krabbe disease (KD) is an autosomal recessive lysosomal disorder caused by mutations in the galactocerebrosidase (GALC) gene. This results in defective myelination in the peripheral and central nervous systems due to low GALC activity. Treatment at this time is limited to hematopoietic stem cell transplantation (HSCT) in pre-symptomatic individuals. Read More

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http://dx.doi.org/10.34172/bi.2020.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186542PMC

Integrated CT imaging and tissue immune features disclose a radio-immune signature with high prognostic impact on surgically resected NSCLC.

Lung Cancer 2020 Jun 21;144:30-39. Epub 2020 Apr 21.

Department of Medicine and Surgery, University of Parma, Medical Oncology Unit, University Hospital of Parma, Via Gramsci 14, 43126, Parma, Italy. Electronic address:

Objectives: Qualitative and quantitative CT imaging features might intercept the multifaceted tumor immune microenvironment (TIME), providing a non-invasive approach to design new prognostic models in NSCLC patients.

Materials And Methods: Our study population consisted of 100 surgically resected NSCLC patients among which 31 served as a validation cohort for quantitative image analysis. TIME was classified according to PD-L1 expression and the magnitude of Tumor Infiltrating Lymphocytes (TILs) and further defined as hot or cold by the tissue analysis of effector (CD8-to-CD3/PD-1-to-CD8) or inert (CD8-to-CD3/PD-1-to-CD8) phenotypes. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.04.006DOI Listing
June 2020
3.958 Impact Factor

Differences in engraftment with day-1 compared with day-2 melphalan prior to stem cell infusion in myeloma patients receiving autologous stem cell transplant.

Bone Marrow Transplant 2020 May 1. Epub 2020 May 1.

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

We conducted a retrospective study comparing posttransplant outcomes between myeloma patients receiving conditioning melphalan on day-2 vs day-1 for autologous stem cell transplant. Between January 2017 and December 2018, 201 patients received melphalan on day-2 and 166 on day-1 prior to stem cell infusion. Baseline disease and clinical characteristics between the two groups were similar. Read More

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http://dx.doi.org/10.1038/s41409-020-0916-3DOI Listing
May 2020
3.570 Impact Factor

Autologous bone marrow-derived mononuclear cell therapy in three patients with severe asthma.

Stem Cell Res Ther 2020 May 1;11(1):167. Epub 2020 May 1.

Institute of Thoracic Medicine, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Despite recent advances in understanding its pathophysiology and development of novel therapies, asthma remains a serious public health issue worldwide. Combination therapy with inhaled corticosteroids and long-acting β-adrenoceptor agonists results in disease control for many patients, but those who exhibit severe asthma are often unresponsive to conventional treatment, experiencing worse quality of life, frequent exacerbations, and increasing healthcare costs. Bone marrow-derived mononuclear cell (BMMC) transplantation has been shown to reduce airway inflammation and remodeling and improve lung function in experimental models of allergic asthma. Read More

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http://dx.doi.org/10.1186/s13287-020-01675-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193384PMC

Impact of autologous blood transfusion after bone marrow harvest on unrelated donor's health and outcome: a CIBMTR analysis.

Bone Marrow Transplant 2020 Apr 30. Epub 2020 Apr 30.

Division of Hematology & Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville, FL, USA.

Pre-harvest autologous blood collection from bone marrow (BM) donors is performed to meet potential post-operative transfusion needs. This study examines the impact of autologous blood transfusion on BM donor's health and safety. The study included first-time unrelated BM donors from the United States whose BM harvest was facilitated by the National Marrow Donor Program (NMDP) centers between 2006 and 2017. Read More

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http://dx.doi.org/10.1038/s41409-020-0911-8DOI Listing

Post-transplant cyclophosphamide versus anti-thymocyte globulin for graft-versus-host disease prevention in haploidentical transplantation for adult acute lymphoblastic leukemia.

Haematologica 2020 Apr 30. Epub 2020 Apr 30.

Saint Antoine Hospital and Université Pierre et Marie Curie, Paris, France.

Graft-versus-host disease (GVHD) prophylaxis for unmanipulated haploidentical hematopoietic cell transplantation (haplo-HCT) include post-transplant cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG). Utilizing EBMT registry, we compared ATG versus PTCy based GVHD prophylaxis in adult acute lymphoblastic leukemia (ALL) patients undergoing haplo-HCT. Included were 434 patients; ATG (n=98) and PTCy (n=336). Read More

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http://dx.doi.org/10.3324/haematol.2020.247296DOI Listing

Osteoblast-Based Therapy-A New Approach for Bone Repair in Osteoporosis: Pre-Clinical Setting.

Tissue Eng Regen Med 2020 Apr 28. Epub 2020 Apr 28.

Hormones Department, Medical Research Division, National Research Centre, 33 EL Bohouth St. (former EL -Tahrir st.)-Dokki, Giza, 12622, Egypt.

Background: Osteoporosis is a metabolic bone disease characterized by low bone density resulting in increased fracture susceptibility. This research was constructed to uncover the potential therapeutic application of osteoblasts transplantation, generated upon culturing male rat bone marrow-derived mesenchymal stem cells (BM-MSCs) in osteogenic medium (OM), OM containing gold (Au-NPs) or gold/hydroxyapatite (Au/HA-NPs) nanoparticles, in ovariectomized rats to counteract osteoporosis.

Methods: Forty rats were randomized into: (1) negative control, (2) osteoporotic rats, whereas groups (3), (4) and (5) constituted osteoporotic rats treated with osteoblasts yielded from culturing BM-MSCs in OM, OM plus Au-NPs or Au/HA-NPs, respectively. Read More

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http://dx.doi.org/10.1007/s13770-020-00249-5DOI Listing
April 2020
0.613 Impact Factor

Bone marrow mesenchymal stem cells combine with normothermic machine perfusion to improve rat donor liver quality-the important role of hepatic microcirculation in donation after circulatory death.

Cell Tissue Res 2020 Apr 29. Epub 2020 Apr 29.

Department of Organ Transplantation, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin, 300192, People's Republic of China.

Donation after circulatory death (DCD) can expand the donor pool effectively. A gap remains in outcome between DCD livers and living donor livers, warranting improved DCD liver quality and urgent resolution. Bone marrow mesenchymal stem cells (BMMSCs) can regulate immunity, participate in the anti-inflammatory response, and secrete cytokines. Read More

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http://dx.doi.org/10.1007/s00441-020-03202-zDOI Listing

Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand.

Transplantation 2020 Apr 24. Epub 2020 Apr 24.

Division of Transplantation Surgery, CLINTEC, Karolinska Institutet, and Department of Transplantation Surgery, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Background: During intraportal pancreatic islet transplantation (PITx), early inflammatory reactions cause an immediate loss of more than half of the transplanted graft and potentiate subsequent allograft rejection. Previous findings suggest that cibinetide, a selective innate repair receptor agonist, exerts islet protective and anti-inflammatory properties and improved transplant efficacy in syngeneic mouse PITx model. In a stepwise approach toward a clinical application, we have here investigated the short and long-term effects of cibinetide in an allogeneic mouse PITx model. Read More

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http://dx.doi.org/10.1097/TP.0000000000003284DOI Listing
April 2020
3.828 Impact Factor

Haploidentical BMT for severe aplastic anemia with intensive GVHD prophylaxis including posttransplant cyclophosphamide.

Blood Adv 2020 Apr;4(8):1770-1779

Department of Oncology, Sidney Kimmel Cancer Center, Baltimore, MD.

Severe aplastic anemia (SAA) is a stem cell disorder often treated with bone marrow transplantation (BMT) to reconstitute hematopoiesis. Outcomes of related HLA-haploidentical (haplo) donors after reduced-intensity conditioning with intensive graft-versus-host disease (GVHD) prophylaxis including posttransplantation cyclophosphamide are presented here from 37 SAA, 20 relapsed/refractory (R/R), and 17 treatment-naïve (TN) SAA patients. Median follow-up is 32 months (90% confidence interval [CI], 29-44). Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189283PMC

Early relapse after complete remission of primary plasma cell leukaemia manifesting clonal evolution: A case report.

Malays J Pathol 2020 Apr;42(1):143-150

Pusat Terapi Sel, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia.

Introduction: Plasma cell leukaemia (PCL) is a rare variant of multiple myeloma. We report a case of PCL to demonstrate the clonal evolution, resulting in disease relapse after achieving complete remission, and its aggressive nature of the disease, leading to poor clinical outcome.

Case Report: A 69-year-old man presented with a three-day-history of worsening generalized body weakness, poor oral intake, nausea, significant loss of weight and lower back pain. Read More

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Pre-transplant FLT3/ITD status predicts outcome in FLT3-mutated acute myeloid leukemia following allogeneic stem cell transplantation.

Ann Hematol 2020 Apr 24. Epub 2020 Apr 24.

Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dąbrowski street 25, 40-032, Katowice, Poland.

Acute myeloid leukemia (AML) with fetal liver tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) is associated with poor prognosis, and allogeneic stem cell transplantation (Allo-SCT) seems to be the preferred therapeutic approach. However, the predictors of post-transplant outcomes were not well-defined. The aim of the study was to evaluate the significance of FLT3/ITD mutation by polymerase chain reaction as minimal residual disease (MRD) marker of outcomes after transplantation. Read More

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http://dx.doi.org/10.1007/s00277-020-04026-1DOI Listing

Comparison of hemorrhagic and ischemic stroke after allogeneic hematopoietic stem cell transplantation.

Bone Marrow Transplant 2020 Apr 24. Epub 2020 Apr 24.

Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.

Stroke is an important complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Nevertheless, few studies have been published to analyzed the occurrence and prognosis of stroke after allo-HSCT. From January 2007 to December 2018 in Peking University People's Hospital, 6449 patients received HSCT and there were 2. Read More

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http://dx.doi.org/10.1038/s41409-020-0903-8DOI Listing
April 2020
3.570 Impact Factor

Deepening responses associated with improved progression-free survival with ixazomib versus placebo as posttransplant maintenance in multiple myeloma.

Leukemia 2020 Apr 23. Epub 2020 Apr 23.

Hematology, Hospital Universitario de Salamanca, University Hospital of Salamanca, IBSAL, CIC, IBMCC (USAL-CSIC), Salamanca, Spain.

In the TOURMALINE-MM3 study, post-autologous stem cell transplantation maintenance therapy with the oral proteasome inhibitor ixazomib versus placebo significantly improved progression-free survival (PFS), with a favorable safety profile. With ixazomib versus placebo maintenance, deepening responses occurred in 139/302 (46%) versus 60/187 (32%) patients with very good partial response or partial response (VGPR/PR) at study entry (relative risk 1.41, P = 0. Read More

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http://dx.doi.org/10.1038/s41375-020-0819-8DOI Listing

A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease.

Blood Adv 2020 Apr;4(8):1656-1669

Division of Oncology, Section of Bone Marrow Transplantation and Leukemia, Washington University School of Medicine in St. Louis, St. Louis, MO.

Acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell transplantation (HCT) is a primary cause of nonrelapse mortality and a major barrier to successful transplant outcomes. Itacitinib is a Janus kinase (JAK)1-selective inhibitor that has demonstrated efficacy in preclinical models of aGVHD. We report results from the first registered study of a JAK inhibitor in patients with aGVHD. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019001043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189299PMC

Autologous hematopoietic stem cell transplantation with reduced-intensity conditioning regimens in refractory Takayasu arteritis: a retrospective multicenter case-series from the Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT).

Bone Marrow Transplant 2020 Apr 22. Epub 2020 Apr 22.

Sorbonne Université, Service de Médecine Interne and Inflammation-Immunopathology-Biotherapy Department (DMU i3), Hôpital Saint-Antoine, APHP, F-75012, Paris, France.

Autologous hematopoietic stem cell transplantation (AHSCT) has emerged as a promising treatment option in severely affected and refractory patients with autoimmune diseases. This is a retrospective survey of patients reported to the EBMT registry between 1998 and 2019, who received AHSCT for TAK. Data from six patients treated with AHSCT for refractory TAK have been identified, five were female (83%), median age 25 (9-39) years. Read More

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http://dx.doi.org/10.1038/s41409-020-0907-4DOI Listing