19,215 results match your criteria Bone Marrow Transplantation Long-Term Effects


Safety and feasibility of outpatient autologous stem cell transplantation in pediatric patients with primary central nervous system tumors.

Bone Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Department of Pediatric Hematology/Oncology/Bone Marrow Transplant, University of Colorado, Children's Hospital Colorado, Aurora, CO, USA.

High-dose chemotherapy with autologous hematopoietic stem cell transplantation (autoHSCT) is a well-established treatment for pediatric central nervous system (CNS) tumors. Given the risks of toxicity and infection, pediatric autoHSCT has been historically performed on hospitalized children. As our practice evolved, some patients were transplanted as outpatients. Read More

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http://dx.doi.org/10.1038/s41409-019-0479-3DOI Listing
February 2019

Liver Transplant in a Patient With Hemophagocytic Lymphohistiocytosis.

Exp Clin Transplant 2019 Jan;17(Suppl 1):226-229

From the Department of Transplantation, Baskent University, Ankara, Turkey.

Hemophagocytic lymphohistiocytosis is a rare and life-threatening systemic disease that can cause hepatic infiltration and present as acute liver failure. Here, we report a case of a 3-year-old pediatric patient who presented with acute liver failure and hepatic encephalopathy secondary to hemophagocytic lymphohistiocytosis. She had left lateral segment liver transplant from her father. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P80DOI Listing
January 2019

Mesenchymal stem cells improve platelet counts in mice with immune thrombocytopenia.

J Cell Biochem 2019 Feb 18. Epub 2019 Feb 18.

Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. The breakdown of immune tolerance (regulatory T [Treg] cells and suppressor cytokines) plays an important role in ITP pathophysiology, especially in refractory ITP. Bone marrow-derived mesenchymal stem cells (BM-MSCs) show immunomodulatory properties and have been extensively utilized for autoimmune diseases. Read More

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http://dx.doi.org/10.1002/jcb.28405DOI Listing
February 2019

Late mortality and causes of death among 5-year survivors of childhood cancer diagnosed in the period 1960-1999 and registered in the Italian Off-Therapy Registry.

Eur J Cancer 2019 Feb 14;110:86-97. Epub 2019 Feb 14.

Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy. Electronic address:

Introduction: Advances in paediatric oncology led to the increase in long-term survival, revealing the burden of therapy-related long-term side effects. We evaluated overall and cause-specific mortality in a large cohort of Italian childhood cancer survivors (CCSs) and adolescent cancer survivors identified through the off-therapy registry.

Materials And Methods: CCSs alive 5 years after cancer diagnosis occurring between 1960 and 1999 were eligible; the last follow-up was between 2011 and 2014. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.021DOI Listing
February 2019

Hematopoietic stem cell transplantation for mucopolysaccharidoses; past, present, and future.

Biol Blood Marrow Transplant 2019 Feb 14. Epub 2019 Feb 14.

Nemours/ Alfred I. duPont Hospital for Children, Wilmington, DE, USA; Department of Pediatrics, Shimane University Faculty of Medicine, Shimane, Japan; Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan; Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Allogenic hematopoietic stem cell transplantation (HSCT) has been shown to be a treatment option for a selected group of patients with mucopolysaccharidoses (MPS) (MPS I, II, IVA, VI, and VII). Early diagnosis and timely referral to an expert in MPS are critical, followed by a complete examination and evaluation with a multidisciplinary team, including a transplant physician. Treatment recommendations for MPS are based on multiple factors such as biological, sociological, and financial effects. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.012DOI Listing
February 2019
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Evaluation of infectious complications after haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide following reduced-intensity and myeloablative conditioning: a study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC).

Bone Marrow Transplant 2019 Feb 15. Epub 2019 Feb 15.

Institut de Cancérologie Lucien Neuwirth, Saint-Etienne, France.

Several approaches have been developed to overcome historical barriers associated with poor outcomes in the setting of HLA-haploidentical allogeneic transplantation (HaploSCT). Here, we examine the outcome of patients with various hematological disorders undergoing HaploSCT with high-dose, post-transplantation cyclophosphamide. We performed a retrospective study on 381 patients from 30 centers between January 2013 and December 2015. Read More

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http://dx.doi.org/10.1038/s41409-019-0475-7DOI Listing
February 2019

Rap1 signal modulators control the maintenance of hematopoietic progenitors in bone marrow and adult long-term hematopoiesis.

Cancer Sci 2019 Feb 15. Epub 2019 Feb 15.

Medical Innovation Center, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan.

Adult long-term hematopoiesis depends on sustaining hematopoietic stem/progenitor cells (HSPCs) in bone marrow (BM) niches, where their balance of quiescence, self-renewal, and hematopoietic differentiation is tightly regulated. While various BM stroma cells that produce niche factors have been identified, regulation of the intrinsic responsiveness of HSPCs to the niche factors remains elusive. We previously reported that mice deficient for Sipa1, a Rap1 GTPase-activating protein, develop diverse hematopoietic disorders of late onset. Read More

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http://dx.doi.org/10.1111/cas.13974DOI Listing
February 2019

Effectiveness and Safety of Micafungin in Managing Invasive Fungal Infections among Patients in Greece with Hematologic Disorders: The ASPIRE Study.

Infect Dis Ther 2019 Feb 14. Epub 2019 Feb 14.

University General Hospital of Larissa, Larissa, Greece.

Introduction: Invasive candidiasis (IC) can be a life-threatening infection in immunocompromised patients, particularly those with cancer, hematologic diseases and/or hematopoietic stem cell transplantation (HSCT) recipients. The objective of this study was to evaluate the effectiveness of micafungin in patients with hematologic malignancies or HSCT recipients, relevant to clinical presentation of IC, in real-life practice in Greece.

Methods: ASPIRE was a phase IV, multicenter, non-interventional, prospective cohort study, conducted at ten tertiary hospitals in Greece, in adults with hematologic disease. Read More

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http://dx.doi.org/10.1007/s40121-019-0236-3DOI Listing
February 2019
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Comprehensive Investigation of miRNome Identifies Novel Candidate miRNA-mRNA Interactions Implicated in T-Cell Acute Lymphoblastic Leukemia.

Neoplasia 2019 Feb 11;21(3):294-310. Epub 2019 Feb 11.

Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland. Electronic address:

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy originating from T-cell precursors. The genetic landscape of T-ALL has been largely characterized by next-generation sequencing. Yet, the transcriptome of miRNAs (miRNome) of T-ALL has been less extensively studied. Read More

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http://dx.doi.org/10.1016/j.neo.2019.01.004DOI Listing
February 2019
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Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered Mesenchymal Stromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice.

Int J Mol Sci 2019 Feb 12;20(3). Epub 2019 Feb 12.

First Department of Ophthalmology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.

This study aimed to investigate whether the transplantation of genetically engineered bone marrow-derived mesenchymal stromal cells (MSCs) to overexpress brain-derived neurotrophic factor (BDNF) could rescue the chronic degenerative process of slow retinal degeneration in the rd6 (retinal degeneration 6) mouse model and sought to identify the potential underlying mechanisms. Rd6 mice were subjected to the intravitreal injection of lentivirally modified MSC-BDNF or unmodified MSC or saline. In vivo morphology, electrophysiological retinal function (ERG), and the expression of apoptosis-related genes, as well as BDNF and its receptor (TrkB), were assessed in retinas collected at 28 days and three months after transplantation. Read More

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http://dx.doi.org/10.3390/ijms20030777DOI Listing
February 2019
1 Read

Combination therapy of an iNKT cell ligand and CD40-CD154 blockade establishes islet allograft acceptance in nonmyeloablative bone marrow transplant recipients.

Acta Diabetol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

Aims: Islet transplantation is an effective therapeutic option for type 1 diabetes. Although maintenance immunosuppression therapy is required to prevent allogeneic rejection and recurrence of autoimmunity, long-term allograft survival has not yet been achieved partly because of its adverse effects. The induction of donor-specific immunotolerance is a promising approach for long-term allograft survival without maintenance immunosuppression therapy. Read More

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http://dx.doi.org/10.1007/s00592-019-01289-7DOI Listing
February 2019
1 Read
2.399 Impact Factor

Matching-Adjusted Indirect Comparison of Blinatumomab vs. Inotuzumab Ozogamicin for Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia.

Adv Ther 2019 Feb 13. Epub 2019 Feb 13.

Centre for Health Economics, University of York, York, UK.

Introduction: In the absence of head-to-head trials, this analysis aimed to provide a fair indirect comparison of the efficacy between blinatumomab and inotuzumab ozogamicin (InO), two treatments for adult patients with relapsed or refractory acute lymphoblastic leukemia (R/R ALL) who received no more than one prior salvage therapy, by adjusting for cross-trial differences.

Methods: Patient-level data from the Phase 3 blinatumomab trial TOWER and published aggregated data from the Phase 3 InO trial INO-VATE-ALL were used to conduct matching-adjusted indirect comparisons. Patients with 2+ prior salvage therapies from TOWER were excluded because such patients were not included in INO-VATE-ALL. Read More

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http://dx.doi.org/10.1007/s12325-019-0873-7DOI Listing
February 2019
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Use of Aspergillus fumigatus real-time PCR in bronchoalveolar lavage samples (BAL) for diagnosis of invasive aspergillosis, including azole-resistant cases, in high risk haematology patients: the need for a combined use with galactomannan.

Med Mycol 2019 Feb 7. Epub 2019 Feb 7.

Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

Diagnosis of invasive aspergillosis (IA) is challenging, particularly in high-risk patients with lung lesions other than typical according to 2008-EORTC/MSG criteria. Even if microbiology is positive, they still remain unclassified according to 2008-EORTC/MSG. Quantitative polymerase chain reaction (qPCR) provides new mycological documentation of IA. Read More

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http://dx.doi.org/10.1093/mmy/myz002DOI Listing
February 2019
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Human bone marrow mesenchymal stem cells functionalized by hybrid baculovirus-adeno-associated viral vectors for targeting hypopharyngeal carcinoma.

Stem Cells Dev 2019 Feb 12. Epub 2019 Feb 12.

Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Otolaryngology , No. 197, Ruijin 2nd Road , Shanghai, China , 200025 ;

Hypopharyngeal carcinoma is a common malignant tumor of the head and neck with a very poor prognosis; the median survival time for curatively treated patients was 17.2 months in India. However, cell-based gene therapy holds promise to improve patient outcomes. Read More

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http://dx.doi.org/10.1089/scd.2018.0252DOI Listing
February 2019
2 Reads

Treatment exposures stratify need for echocardiographic screening in asymptomatic long-term survivors of hematopoietic stem cell transplantation.

Cardiol Young 2019 Feb 12:1-6. Epub 2019 Feb 12.

2Division of Cardiology,Cincinnati Children's Hospital Medical Center,Cincinnati, OH,USA.

We sought to define the prevalence of echocardiographic abnormalities in long-term survivors of paediatric hematopoietic stem cell transplantation and determine the utility of screening in asymptomatic patients. We analysed echocardiograms performed on survivors who underwent hematopoietic stem cell transplantation from 1982 to 2006. A total of 389 patients were alive in 2017, with 114 having an echocardiogram obtained ⩾5 years post-infusion. Read More

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http://dx.doi.org/10.1017/S104795111800238XDOI Listing
February 2019

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation.

Nat Biotechnol 2019 Feb 11. Epub 2019 Feb 11.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility. Here we report a biomaterial-based scaffold that mimics features of T cell lymphopoiesis in the bone marrow. The bone marrow cryogel (BMC) releases bone morphogenetic protein-2 to recruit stromal cells and presents the Notch ligand Delta-like ligand-4 to facilitate T cell lineage specification of mouse and human hematopoietic progenitor cells. Read More

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http://dx.doi.org/10.1038/s41587-019-0017-2DOI Listing
February 2019
3 Reads
41.514 Impact Factor

Molecular signature of human bone marrow-derived mesenchymal stromal cell subsets.

Sci Rep 2019 Feb 11;9(1):1774. Epub 2019 Feb 11.

University Hospital for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, Frankfurt am Main, Germany.

In the current study we compared the molecular signature of expanded mesenchymal stromal cells (MSCs) derived from selected CD271+ bone marrow mononuclear cells (CD271-MSCs) and MSCs derived from non-selected bone marrow mononuclear cells by plastic adherence (PA-MSCs). Transcriptome analysis demonstrated for the first time the upregulation of 115 and downregulation of 131 genes in CD271-MSCs. Functional enrichment analysis showed that the upregulated genes in CD271-MSCs are significantly enriched for extracellular matrix (tenascin XB, elastin, ABI family, member 3 (NESH) binding protein, carboxypeptidase Z, laminin alpha 2 and nephroblastoma overexpressed) and cell adhesion (CXCR7, GPNMB, MYBPH, SVEP1, ARHGAP6, TSPEAR, PIK3CG, ABL2 and NCAM1). Read More

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http://www.nature.com/articles/s41598-019-38517-7
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http://dx.doi.org/10.1038/s41598-019-38517-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370815PMC
February 2019
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PGS Scaffolds Promote the In Vivo Survival and Directional Differentiation of Bone Marrow Mesenchymal Stem Cells Restoring the Morphology and Function of Wounded Rat Uterus.

Adv Healthc Mater 2019 Feb 7:e1801455. Epub 2019 Feb 7.

Department of Medical Genetics, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, P. R. China.

Intrauterine adhesion (IUA) causing infertility and recurrent miscarriage of reproductive female mammals usually results from endometrium injury. Nevertheless, there is no efficient therapeutic method to avoid IUA. Bone marrow derived mesenchymal stem cells (BMSCs) are an important cell source for tissue regeneration. Read More

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http://dx.doi.org/10.1002/adhm.201801455DOI Listing
February 2019

Sequential therapy for patients with primary refractory acute myeloid leukemia - historical prospective analysis of the German and Israeli experience.

Haematologica 2019 Feb 7. Epub 2019 Feb 7.

Department I of Internal Medicine, University of Cologne, Germany.

Primary refractory acute myeloid leukemia is associated with a dismal prognosis. The fludarabine, amsacrine, and cytarabine-reduced-intensity conditioning protocol (total body irradiation or treosulfan-based) has been described to be an effective approach in patients with refractory leukemia undergoing allogeneic hematopoietic cell transplantation . A modified protocol (without amsacrine) has been also used recently. Read More

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http://dx.doi.org/10.3324/haematol.2018.203869DOI Listing
February 2019
1 Read

Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation.

Nat Commun 2019 Feb 6;10(1):616. Epub 2019 Feb 6.

Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, 20892, MD, USA.

Hematopoietic chimerism after allogeneic bone marrow transplantation may establish a state of donor antigen-specific tolerance. However, current allotransplantation protocols involve genotoxic conditioning which has harmful side-effects and predisposes to infection and cancer. Here we describe a non-genotoxic conditioning protocol for fully MHC-mismatched bone marrow allotransplantation in mice involving transient immunosuppression and selective depletion of recipient hematopoietic stem cells with a CD117-antibody-drug-conjugate (ADC). Read More

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http://dx.doi.org/10.1038/s41467-018-08202-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365540PMC
February 2019
1 Read

Tonic Signaling and Its Effects on Lymphopoiesis of CAR-Armed Hematopoietic Stem and Progenitor Cells.

J Immunol 2019 Feb 6. Epub 2019 Feb 6.

Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, Technical University Dresden, 01307 Dresden, Germany.

Long-term survival of adoptively transferred chimeric Ag receptor (CAR) T cells is often limited. Transplantation of hematopoietic stem cells (HSCs) transduced to express CARs could help to overcome this problem as CAR-armed HSCs can continuously deliver CAR multicell lineages (e.g. Read More

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http://dx.doi.org/10.4049/jimmunol.1801004DOI Listing
February 2019

High probability of follow-up termination among AYA survivors after allogeneic hematopoietic cell transplantation.

Blood Adv 2019 Feb;3(3):397-405

Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.

The need for long-term follow-up (LTFU) after allogeneic hematopoietic cell transplantation (HCT) has been increasingly recognized for managing late effects such as subsequent cancers and cardiovascular events. A substantial population, however, has already terminated LTFU at HCT centers. To better characterize follow-up termination, we analyzed the Japanese transplant registry database. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018026039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373751PMC
February 2019
1 Read

T-cell frequencies of CD8 γδ and CD27 γδ cells in the stem cell graft predict the outcome after allogeneic hematopoietic cell transplantation.

Bone Marrow Transplant 2019 Feb 5. Epub 2019 Feb 5.

Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

The impact of intra-graft T cells on the clinical outcome after allogeneic hematopoietic cell transplantation has been investigated. Most previous studies have focused on the role of αβ cells while γδ cells have received less attention. It has been an open question whether γδ cells are beneficial or not for patient outcome, especially with regards to graft versus host disease. Read More

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http://dx.doi.org/10.1038/s41409-019-0462-zDOI Listing
February 2019
1 Read

Epidermal growth factor-like repeats of SCUBE1 derived from platelets are critical for thrombus formation.

Cardiovasc Res 2019 Feb 5. Epub 2019 Feb 5.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Aims: SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1), expressed in endothelial cells (ECs) and platelets, exists in soluble or membrane forms. We previously showed that soluble SCUBE1 is a biomarker for platelet activation and also an active participant of thrombosis. However, whether the adhesive module of its EGF-like repeats is essential and the specific contribution of SCUBE1 synthesized in ECs or platelets to thrombosis in vivo remain unclear. Read More

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http://dx.doi.org/10.1093/cvr/cvz036DOI Listing
February 2019
1 Read

The concentration of total nucleated cells in harvested bone marrow for transplantation has decreased over time.

Biol Blood Marrow Transplant 2019 Feb 1. Epub 2019 Feb 1.

CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:

Bone Marrow (BM) is an essential hematopoietic stem cell (HSC) source for many allogeneic hematopoietic cell transplant (HCT) recipients, including adult patients (for specific diseases and transplant strategies) and the majority of pediatric transplants. However, since the advent of Granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSC), there has been a significant decrease in utilization of BM in transplant patients, predominantly thought to be due to the increased logistical challenges around BM harvesting compared to PBSC, and generally no significant survival advantage of BM or PBSC. The decreased frequency of collection has the potential to impact the quality of BM harvests. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.01.034DOI Listing
February 2019

Eltrombopag for Treating Thrombocytopenia after Allogeneic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2019 Jan 30. Epub 2019 Jan 30.

Blood and Marrow Transplant Center, Florida Hospital Cancer Institute, Orlando, Florida. Electronic address:

Thrombocytopenia after allogeneic hematopoietic stem cell transplantation (allo-SCT) can pose significant problems in management of patients. Eltrombopag is a small-molecule thrombopoietin receptor agonist that has been approved for use in immune thrombocytopenic purpura and aplastic anemia; but its use after allo-SCT is limited. Between 2014 and 2017, we treated 13 patients with eltrombopag for poor platelet engraftment without evidence of relapse at the time of initiation, including 6 patients with primary platelet engraftment failure and 7 with secondary platelet engraftment failure. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.01.027DOI Listing
January 2019
1 Read
3.404 Impact Factor

Canonical WNT Signaling Pathway is Altered in Mesenchymal Stromal Cells From Acute Myeloid Leukemia Patients And Is Implicated in BMP4 Down-Regulation.

Transl Oncol 2019 Jan 28;12(4):614-625. Epub 2019 Jan 28.

Stem Cell Laboratory, Bone Marrow Transplantation Unit, National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil. Electronic address:

Mesenchymal stromal cells (hMSCs) are key components of the bone marrow microenvironment (BMM). A molecular signature in hMSCs from Acute myeloid leukemia patients (hMSC-AML) has been proposed where BMP4 is decreased and could be regulated by WNT signaling pathway. Therefore, the aim of this work was to verify whether the WNT signaling pathway can regulate the BMP4 gene in hMSCs. Read More

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http://dx.doi.org/10.1016/j.tranon.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350721PMC
January 2019
1 Read

Results of program acute myeloid leukemia therapy use in National Medical Research Center for Hematology of the Ministry of Health of Russian Federation.

Ter Arkh 2018 Aug;90(7):14-22

National Research Center for Hematology, Moscow, Russia.

Aim: To analyze treatment results of 172 patients with acute myeloid leukemia (AML) aged 18-60 years in National Medical Research Center for Hematology of MHRF.

Materials And Methods: Inductive and consolidation program for 139 (80%) patients was based on a standardized protocol: 4 courses "7+3" with different anthracycline use (2 courses of daunorubicin, idarubicin, mitoxantrone) and continuous use of cytarabine on the second inductive course. In 20% of patients cytarabine courses at the dose of 1 g/m2 2 times a day for 1-3 days combined with idarubicin and mitoxantrone were used as two consolidation courses. Read More

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http://dx.doi.org/10.26442/terarkh201890714-22DOI Listing
August 2018
1 Read

Current development of chimeric antigen receptor T-cell therapy.

Stem Cell Investig 2018 3;5:44. Epub 2018 Dec 3.

Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.

Chimeric antigen receptor (CAR) T-cell therapy has achieved great success in recent years, with encouraging complete remission rate and long-term durability of response, especially in advanced B-cell malignancies. With the approval of tisagenlecleucel and axi-cel by FDA to treat refractory/relapsed acute lymphoblastic leukemia and non-Hodgkin lymphoma, our understanding of CAR T cells has been progressing rapidly. In this review, we discussed the designs of CAR T cells, factors affecting response, adverse effects, as well as application beyond B-cell malignancies. Read More

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http://sci.amegroups.com/article/view/22694/html
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http://dx.doi.org/10.21037/sci.2018.11.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327156PMC
December 2018
14 Reads

Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres.

Bone Marrow Transplant 2019 Jan 29. Epub 2019 Jan 29.

CHU de Liège, Liège, Belgium.

While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007-2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. Read More

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http://dx.doi.org/10.1038/s41409-019-0458-8DOI Listing
January 2019
1 Read

Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes: a CIBMTR contemporary longitudinal study.

Bone Marrow Transplant 2019 Jan 29. Epub 2019 Jan 29.

Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Limited data exist on characteristics of central nervous system viruses (CNS-V) in allogeneic hematopoietic stem cell transplant (HCT) recipients. Between 2007 and 2015, the Center for International Blood and Marrow Transplant Research (CIBMTR) received information on 27,532 patients undergoing HCT. Of these, centers reported 165 HCT recipients with CNS-V detected in cerebrospinal fluid within 6 months after HCT. Read More

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http://dx.doi.org/10.1038/s41409-019-0457-9DOI Listing
January 2019
2 Reads

Space for intuition - the 'Surprise'-Question in haemato-oncology: Qualitative analysis of experiences and perceptions of haemato-oncologists.

Palliat Med 2019 Jan 28:269216318824271. Epub 2019 Jan 28.

3 King's College London, Cicely Saunders Institute, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, London, UK.

Background:: Early integration of palliative care can improve outcomes for people with cancer and non-cancer diagnoses. However, prediction of survival for individuals is challenging, in particular in patients with haematological malignancies who are known to have limited access to palliative care. The 'Surprise'-Question can be used to facilitate referral to palliative care. Read More

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http://dx.doi.org/10.1177/0269216318824271DOI Listing
January 2019

New principles of cancer therapy give new hope for oncological patients.

Bratisl Lek Listy 2019 ;120(1):15-18

The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation". A number of therapeutic approaches are available for cancer treatment, including surgery, radiation, and other strategies, some of which have been awarded previous Nobel Prizes. Read More

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http://dx.doi.org/10.4149/BLL_2019_002DOI Listing
January 2019
6 Reads

Repair of Peripheral Nerve Sensory Impairments via the Transplantation of Bone Marrow Neural Tissue-Committed Stem Cell-Derived Sensory Neurons.

Cell Mol Neurobiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Human Anatomy, College of Basic Medical Sciences, Binzhou Medical University, Yantai, 264003, People's Republic of China.

The present study aimed to investigate the efficacy of transplantation of bone marrow neural tissue-committed stem cell-derived sensory neuron-like cells for the repair of peripheral nerve sensory impairments in rats. Bone marrow was isolated and cultured to obtain the neural tissue-committed stem cells (NTCSCs), and the differentiation of these cells into sensory neuron-like cells was induced. Bone marrow mesenchymal stem cells (BMSCs), bone marrow NTCSCs, and bone marrow NTCSC-derived sensory neurons (NTCSC-SNs) were transplanted by microinjection into the L4 and L5 dorsal root ganglions (DRGs) in an animal model of sensory defect. Read More

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http://dx.doi.org/10.1007/s10571-019-00650-2DOI Listing
January 2019
2 Reads

Assessment of the proposed EBMT pediatric criteria for diagnosis and severity grading of sinusoidal obstruction syndrome.

Bone Marrow Transplant 2019 Jan 25. Epub 2019 Jan 25.

Institute for Inflammation Research, Department of Rheumatology and Spine Disease, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Sinusoidal obstruction syndrome (SOS) is a potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). We assessed the proposed pediatric EBMT criteria along with the Baltimore and modified Seattle criteria in a population-based cohort. Eighty-seven children (1. Read More

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http://dx.doi.org/10.1038/s41409-018-0426-8DOI Listing
January 2019
2 Reads

Eltrombopag for post-transplant cytopenias due to poor graft function.

Bone Marrow Transplant 2019 Jan 24. Epub 2019 Jan 24.

Hematology, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.

Persistent cytopenia due to poor graft function (PoGF) is a relatively common complication which may affect up to 20% of patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Treatment options for PoGF remain limited, and reinfusion of additional HSC is often the only way to rescue hematopoiesis. Here we describe a retrospective single-center experience with the thrombopoietin-mimetic agent eltrombopag for the treatment of PoGF. Read More

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http://dx.doi.org/10.1038/s41409-019-0442-3DOI Listing
January 2019

T Cell Repertoire Evolution after Allogeneic Bone Marrow Transplantation: An Organizational Perspective.

Biol Blood Marrow Transplant 2019 Jan 21. Epub 2019 Jan 21.

Bone Marrow Transplant Program, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia. Electronic address:

High-throughput sequencing (HTS) of human T cell receptors has revealed a high level of complexity in the T cell repertoire, which makes it difficult to correlate T cell reconstitution with clinical outcomes. The associations identified thus far are of a broadly statistical nature, precluding precise modeling of outcomes based on T cell repertoire development following bone marrow transplantation (BMT). Previous work has demonstrated an inherent, mathematically definable order observed in the T cells from a diverse group of donors, which is perturbed in recipients following BMT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10838791193007
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http://dx.doi.org/10.1016/j.bbmt.2019.01.021DOI Listing
January 2019
2 Reads

Lung resistance-related protein (LRP) predicts favorable therapeutic outcome in Acute Myeloid Leukemia.

Sci Rep 2019 Jan 23;9(1):378. Epub 2019 Jan 23.

Jinnah Medical and Dental College, Karachi, Pakistan.

There is conflicting evidence that MDR1, MRP2 and LRP expression is responsible for chemotherapy resistance. We conducted this study to explore their role in AML therapy outcomes. Bone marrow and peripheral blood samples of 90 AML patients, receiving chemotherapy, were analyzed by real time PCR. Read More

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http://www.nature.com/articles/s41598-018-36780-8
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http://dx.doi.org/10.1038/s41598-018-36780-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344578PMC
January 2019
5 Reads

Detection of Mutations Using High Resolution Melting Curve Analysis (HRM-A); Application on a Large Cohort of Greek ET and MF Patients.

Mediterr J Hematol Infect Dis 2019 1;11(1):e2019009. Epub 2019 Jan 1.

Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece.

Background And Objectives: Somatic mutations in the calreticulin gene () are detected in approximately 70% of patients with essential thrombocythemia (ET) and primary or secondary myelofibrosis (MF), lacking the and mutations. To determine the prevalence of frameshift mutations in a population of MPN patients of Greek origin, we developed a rapid low-budget PCR-based assay and screened samples from 5 tertiary Haematology units. This is a first of its kind report of the Greek patient population that also disclosed novel mutants. Read More

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http://dx.doi.org/10.4084/MJHID.2019.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328041PMC
January 2019
1 Read

Prognosis of relapse after hematopoietic cell transplant (HCT) for treatment of leukemia or myelodysplastic syndrome (MDS) in children.

Bone Marrow Transplant 2019 Jan 22. Epub 2019 Jan 22.

Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA.

We studied 232 consecutive children transplanted between 1990 and 2011 with relapse after first hematopoietic cell transplant (HCT). Kaplan-Meier survival and hazard ratios for mortality were calculated for factors known at time of relapse using Cox proportional hazards models. The median (range) age at time of first HCT was 10. Read More

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http://dx.doi.org/10.1038/s41409-019-0438-zDOI Listing
January 2019
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Association of Matched Sibling Donor Hematopoietic Stem Cell Transplantation With Transcranial Doppler Velocities in Children With Sickle Cell Anemia.

JAMA 2019 01;321(3):266-276

Department of Statistics, Saint-Louis Hospital, ECSTRA Team, UMR1153, INSERM, University Paris-Diderot, Paris, France.

Importance: In children with sickle cell anemia (SCA), high transcranial Doppler (TCD) velocities are associated with stroke risk, which is reduced by chronic transfusion. Whether matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) can reduce velocities in patients with SCA is unknown.

Objective: To determine the association of MSD-HSCT with TCD velocities as a surrogate for the occurrence of ischemic stroke in children with SCA. Read More

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http://dx.doi.org/10.1001/jama.2018.20059DOI Listing
January 2019
13 Reads

Improving security of autologous hematopoietic stem cell transplant in patients with light-chain amyloidosis.

Bone Marrow Transplant 2019 Jan 21. Epub 2019 Jan 21.

Amyloidosis and Multiple Myeloma Unit, Department of Hematology, Hospital Clínic of Barcelona, Barcelona, Spain.

Autologous stem cell transplant (ASCT) has demonstrated to be an effective treatment for patients with light-chain (AL) amyloidosis. However, a high transplant-related mortality (TRM) rate was reported in previous series of patients and questioned the role of transplant in this disease. Recently, experienced groups have shown a significant TRM decrease that has been attributed to an accurate selection of patients. Read More

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http://dx.doi.org/10.1038/s41409-019-0447-yDOI Listing
January 2019
2 Reads

EBMT prospective observational study on allogeneic hematopoietic stem cell transplantation in T-prolymphocytic leukemia (T-PLL).

Bone Marrow Transplant 2019 Jan 21. Epub 2019 Jan 21.

University of Heidelberg, Heidelberg, Germany.

Preliminary data suggest that allogeneic stem cell transplantation (allo-SCT) may be effective in T-prolymphocytic leukemia (T-PLL). The purpose of the present observational study was to assess the outcome of allo-SCT in patients aged 65 years or younger with a centrally confirmed diagnosis of T-PLL. Patients were consecutively registered with the EBMT at the time of transplantation and followed by routine EBMT monitoring but with an extended dataset. Read More

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http://www.nature.com/articles/s41409-019-0448-x
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http://dx.doi.org/10.1038/s41409-019-0448-xDOI Listing
January 2019
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Clinical implications of measurable residual disease in AML: Review of current evidence.

Crit Rev Oncol Hematol 2019 Jan 24;133:142-148. Epub 2018 Nov 24.

Ghent University Hospital, Laboratory of Molecular Diagnostics, C. Heymanslaan 10, 9000 Ghent, Belgium. Electronic address:

Despite the fact that 80% of adult acute myeloid leukaemia patients reach complete morphological remission after induction chemotherapy, many of them relapse. Many studies have shown that detection of minimal residual disease (defined as 'any detectable evidence of persistent leukaemic cells during complete morphological remission') has an added value in prediction of relapse and survival, and is more than just a surrogate marker for already known risk factors in AML. As such, the behaviour of the disease during treatment might become equally or even more important to decide whether or not an upgrade of treatment (such as an allogeneic stem cell transplantation) is necessary to improve outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10408428183022
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http://dx.doi.org/10.1016/j.critrevonc.2018.11.010DOI Listing
January 2019
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Extramedullary Relapse of Acute Myelogenous Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2019 Jan 17. Epub 2019 Jan 17.

Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.

The clinical significance of extramedullary relapse (EMR) of acute myelogenous leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains poorly defined. Here we report the clinical outcomes of patients who underwent allo-HSCT for AML at our institution between 2000 and 2012. A total of 293 patients with AML who underwent allo-HSCT were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10838791193002
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http://dx.doi.org/10.1016/j.bbmt.2019.01.011DOI Listing
January 2019
6 Reads

Immune checkpoint inhibitors-related rheumatic diseases: what rheumatologist should know?

Curr Rheumatol Rev 2019 Jan 18. Epub 2019 Jan 18.

Istinye University Faculty of Medicine, Liv Hospital, Department of Rheumatology, Istanbul. Turkey.

Immune checkpoint inhibitors are revolutionized drugs for cancer immunotherapy in the last years. The mechanism of action of CPIs including the limitation of the activation of T-cells, and thus enhancing the self-immune response against tumour cells. Checkpoint-inhibitors(CPIs) may dysregulate the immune system which resulting in some toxicities. Read More

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http://www.eurekaselect.com/169153/article
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http://dx.doi.org/10.2174/1573397115666190119094736DOI Listing
January 2019
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Utility of 18-fluorodeoxyglucose positron emission tomography in children with relapsed/refractory leukemia.

Pediatr Hematol Oncol 2019 Jan 18:1-14. Epub 2019 Jan 18.

a Department of Pediatrics, Pediatric Hematology Unit , Gazi University, Faculty of Medicine , Ankara , Turkey.

Objective: Few data are available on the clinical significance of 18-fluorodeoxyglucose positron emission tomography (FDG-PET/CT) results in patients with leukemia. We investigated the utility of FDG-PET/CT at the time of relapsed/refractory disease in pediatric patients with leukemia.

Methods: Medical records of 28 children with suspected leukemia progression or recurrence during/after chemotherapy or allogeneic stem cell transplantation (allo-SCT) were retrospectively reviewed to determine the utility of FDG-PET/CT. Read More

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http://dx.doi.org/10.1080/08880018.2018.1557306DOI Listing
January 2019
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Bloodstream infection (BSI) due to Vancomycin-Resistant Enterococcus (VRE) is associated with increased mortality after hematopoietic cell transplantation for acute leukemia and myelodysplastic syndrome: A multicenter, retrospective cohort study.

Clin Infect Dis 2019 Jan 14. Epub 2019 Jan 14.

Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

Background: We examined the impact of Enterococcus (VRE) bloodstream infection (BSI) on outcomes of allogeneic hematopoietic cell transplantation (HCT) utilizing the Center for International Blood and Marrow Transplant Research (CIBMTR) database.

Methods: Adult and pediatric patients (n=7,128), who underwent first HCT for acute leukemia or myelodysplastic syndrome from 2008 through 2012, were analyzed as 3 groups-VRE-BSI, non-VRE-BSI, without BSI-according to BSI status at 100 days (D100) after allogeneic HCT. Multivariable models examined the effect of VRE-BSI for overall survival (OS) and non-relapse mortality (NRM) at 1 year. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz031DOI Listing
January 2019
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Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch.

J Neuroinflammation 2019 Jan 15;16(1). Epub 2019 Jan 15.

Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Guangzhou, 510282, China.

Background: Activated microglia-mediated neuroinflammation has been regarded as an underlying key player in the pathogenesis of subarachnoid hemorrhage (SAH)-induced early brain injury (EBI). The therapeutic potential of bone marrow mesenchymal stem cells (BMSCs) transplantation has been demonstrated in several brain injury models and is thought to involve modulation of the inflammatory response. The present study investigated the salutary effects of BMSCs on EBI after SAH and the potential mechanism mediated by Notch1 signaling pathway inhibition. Read More

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-019-1396-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334441PMC
January 2019
8 Reads

Potential Risks to Stable Long-term Outcome of Allogeneic Hematopoietic Stem Cell Transplantation for Children With Cerebral X-linked Adrenoleukodystrophy.

JAMA Netw Open 2018 Jul 6;1(3):e180769. Epub 2018 Jul 6.

Department of Pediatric Neurology, University Medical Center Göttingen, Göttingen, Germany.

Importance: Allogeneic hematopoietic stem cell transplantation is the standard intervention for childhood cerebral X-linked adrenoleukodystrophy. However, the pretransplant conditions, demyelination patterns, complications, and neurological outcomes of this therapy are not well characterized.

Objectives: To identify the risks to stable neurocognitive survival after hematopoietic stem cell transplantation and to describe subgroups of patients with distinct clinical long-term outcomes. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.0769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324299PMC
July 2018
8 Reads