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Infect Disord Drug Targets 2019 Mar 7. Epub 2019 Mar 7.

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran. Iran.

Background: Brucellosis, a major health problem in developing countries, is a multisystem infection with a broad spectrum of clinical manifestations. Hematological complications, ranging from an intravascular coagulopathy to mild homeostasis disorders (such as gammopathy), have been reported in brucella infection. These signs and symptoms may lead to misdiagnosis of brucellosis with other hematological diseases. Read More

J Surg Res 2019 Mar 4;239:191-200. Epub 2019 Mar 4.

Department of Surgery, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitaetsmedizin, Berlin, Germany.

Background: Mesenchymal stem cells (MSCs) have been suggested to augment liver regeneration after surgically and pharmacologically induced liver failure. To further investigate this we processed human bone marrow-derived MSC according to good manufacturing practice (GMP) and tested those cells for their modulatory capacities of metabolic alterations and liver regeneration after partial hepatectomy in BALB/c nude mice.

Methods: Human MSCs were obtained by bone marrow aspiration of healthy donors as in a previously described GMP process. Read More

Clin Nephrol Case Stud 2019 10;7:7-10. Epub 2019 Feb 10.

Department of Medicine, Division of Nephrology, Medical University of South Carolina.

Refractory ascites as the only presenting feature of an extramedullary plasmacytoma complicating end-stage renal disease and HIV infection has not been described yet. We describe a case of a 39-year-old female with HIV-associated nephropathy manifesting with ascites formation after transition from peritoneal dialysis (PD) to hemodialysis (HD). Earlier on, she received cycler-assisted PD for 5 years uneventfully. Read More

Int J Gynecol Pathol 2019 Mar 1. Epub 2019 Mar 1.

Departments of Obstetrics and Gynecology (K.P.R., S.G.K.) Pathology (F.H.G., L.A.N.) Internal Medicine, Albert Schweitzer Hospital (M.D.L.), Dordrecht, The Netherlands.

Vulvar malignancies are rare and have diverse origins and presentations. The majority of these tumors are squamous cell carcinoma. An ulcerating vulvar tumor was found in a 74-yr-old woman presenting with fatigue and leukocytosis. Read More

J Vis Exp 2019 Jan 26(143). Epub 2019 Jan 26.

Department of Pediatrics, Kobe University Graduate School of Medicine;

Mesenchymal stem cells (MSCs) have considerable therapeutic potential and attract increasing interest in the biomedical field. MSCs are originally isolated and characterized from bone marrow (BM), then acquired from tissues including adipose tissue, synovium, skin, dental pulp, and fetal appendages such as placenta, umbilical cord blood (UCB), and umbilical cord (UC). MSCs are a heterogeneous cell population with the capacity for (1) adherence to plastic in standard culture conditions, (2) surface marker expression of CD73/CD90/CD105/CD45/CD34/CD14/CD19/HLA-DR phenotypes, and (3) trilineage differentiation into adipocytes, osteocytes, and chondrocytes, as currently defined by the International Society for Cellular Therapy (ISCT). Read More

Case Rep Hematol 2019 9;2019:3879148. Epub 2019 Jan 9.

Section of Hematology, Department of Medicine, UP-Philippine General Hospital, Manila, Philippines.

Bone marrow abnormalities in SLE are now becoming increasingly recognized, suggesting that the bone marrow may also be an important site of target organ damage. In this study, we present a rare case of concurrent autoimmune hemophagocytic syndrome and autoimmune myelofibrosis, potentially life-threatening conditions, in a newly diagnosed SLE patient. We report a case of a 30-year-old Filipino woman who presented with a one-year history of fever, constitutional symptoms, exertional dyspnea, joint pains, and alopecia and physical examination findings of fever, facial flushing, cervical lymphadenopathies, and knee joint effusions. Read More

Rinsho Ketsueki 2019 ;60(1):39-45

Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University.

T-cell large granular lymphocyte (T-LGL) leukemia is a chronic T-cell monoclonal disease that is occasionally associated with pure red cell aplasia (PRCA). A 71-year-old previously healthy man complained of physical fatigue and exhibited anemia (hemoglobin, 10.5 g/dl) with lymphocytosis (76%) showing LGL. Read More

J Clin Lab Anal 2019 Feb 6:e22841. Epub 2019 Feb 6.

Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.

Background: Bone marrow (BM) study plays an important role as initial investigation specimen of lymphoma as well as staging lymphoma. This study aimed to investigate the utility of BM studies for classification of lymphoma and evaluate features of BM involvement by lymphoma over a period of 11 years.

Methods: A total of 1162 cases of BM studies for lymphoma evaluation were reviewed for the incidence of lymphoma subtypes, the percentage of marrow involvement, the pattern of involvement and discordance with histopathologic diagnoses of lymph nodes and other tissues. Read More

J Cardiothorac Surg 2019 Feb 4;14(1):30. Epub 2019 Feb 4.

Cardiac Surgery Department, Peking University People's Hospital, Beijing, 100044, China.

Background: Primary cardiac sarcomas are exceedingly rare, and they commonly result in nonspecific constitutional symptoms such as shortness of breath, weight loss, and anaemia-related fatigue and malaise. However, thrombocytopenia has very rarely been reported in association with cardiac tumours, either benign or malignant. We report one case of primary cardiac synovial sarcoma continuous with the mitral valve, which was accompanied by severe thrombocytopenia, and the platelet counts returned rapidly to a normal range early after tumour excision and without any special therapies. Read More

Dermatol Online J 2019 Jan 15;25(1). Epub 2019 Jan 15.

Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana.

A 26-year-old man with a history of congenital bilateral microtia, unilateral renal agenesis, left aural atresia, and right external auditory canal occlusion admitted for right rib cartilage graft harvest and left ear re-construction. Following surgery, an ulceration with violaceous borders and a yellow fibrinous base unresponsive to broad-spectrum antibiotics developed at the harvest site. The wound was expanding and not responsive to systemic broad-spectrum antibiotics. Read More

Int J Hematol 2019 Jan 31. Epub 2019 Jan 31.

Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.

Aggressive natural killer cell leukemia (ANKL) is a rare neoplasm characterized by the systemic infiltration of Epstein-Barr virus (EBV)-associated NK cells, and rapidly progressive clinical course. We report the case of a 45-year-old man with intellectual disability who developed ANKL, and describe the identification of a novel genetic mutation of coiled-coil domain-containing 22 (CCDC22). He presented with persistent fever, severe pancytopenia, and hepatosplenomegary. Read More

J Stem Cells Regen Med 2018 30;14(2):63-68. Epub 2018 Dec 30.

Department of Orthopaedic Surgery, College of Medicine, Imam AbdulRahman Bin Faisal University and King Fahd Hospital of the University, AlKhobar, Saudi Arabia.

: The objective of this study is to assess if infusion of osteoblasts can temporarily reverse osteoporosis in rats. Osteoporosis was induced in 20 female Sprague-Dawley rats by performing ovariectomy (OVX) that was carried out at 4 weeks of age. At 3 months a biopsy of the iliac crest was made to assess the bone quality and the same site bone marrow was harvested. Read More

Ocul Oncol Pathol 2018 Jun 22;4(4):220-224. Epub 2017 Dec 22.

Department of Ophthalmology, University of Washington, WA, USA.

Purpose: The aim of this paper is to describe a case of relapsed pediatric acute lymphoblastic leukemia (ALL) presenting as a rapidly progressive subretinal infiltrate, as diagnosed by ultrasound-guided fine needle aspiration (FNA).

Methods: We conducted a clinical pathological retrospective chart review.

Results: Eleven months after documented remission of T-cell ALL while on maintenance therapy, this 17-year-old patient presented with acute open angle glaucoma in the right eye. Read More

Trop Doct 2019 Jan 6:49475518822844. Epub 2019 Jan 6.

5 Associate Professor, Department of General Medicine, Pondicherry Institute of Medical Sciences, Pondicherry, India.

Five-year clinico-laboratory data from 99 (one HIV seropositive) adults (mean age = 41.3 ± 20.4 years) who underwent bone marrow examination for fever persisting for ≥ 1 week were analysed and correlated with microbiological characteristics. Read More

Medicine (Baltimore) 2019 Jan;98(1):e14011

FUNDALEU, Buenos Aires, Argentina.

Rationale: The gene deletion (5)(q22q35) is reported in 10-20% of myelodysplastic syndrome (MDS) cases and is associated with response to lenalidomide and favorable prognosis. The authors report here a clinical case of MDS transformation to B-cell acute lymphocytic leukemia (B-ALL) with an associated accrual of an additional mutation following treatment with lenalidomide.

Patient Concerns: A 69-year-old man presented with progressive anemia, normal white blood cell count, and thrombocytopenia consistent with MDS. Read More

J Cancer Res Clin Oncol 2019 Feb 2;145(2):535-542. Epub 2019 Jan 2.

Research Institute of Medical Cell Technologies, 22A, K. Marx st, Yekaterinburg, 620026, Russian Federation.

Purpose: Multicolor flow cytometry (MFC) is widely available, fast and has an easy-to perform approach for finding neuroblastoma (NB) cells among normal bone marrow (BM) hematopoietic cells. Aim of the study was to investigate prognostic significance of initial MFC tumor cells' detection in BM of children with NB.

Methods: 51 patients (24 boys and 27 girls) aged from 6 days to 15 years (median age 1 year 3 months) with NB were included in the study. Read More

Blood Cells Mol Dis 2019 Mar 14;75:20-25. Epub 2018 Dec 14.

M.B.B.Ch. Faculty of Medicine, Benha University, Egypt.

Interleukin-17F rs763780 (7488A/G) gene polymorphism obviously affecting the expression and activity of IL17F and may affect primary immune thrombocytopenia (PIT) susceptibility and its clinical features in Egyptian children and adults. 105 ITP patients divided into (63 pediatric and 42 adult patient) and 112 age and sex matched healthy controls were enrolled in this case control study. All patients were subjected to history taking; clinical examination, CBC, bone marrow aspiration and genotyping of IL17F rs763780 polymorphism by (PCR-RFLP) technique. Read More

Medicine (Baltimore) 2018 Dec;97(52):e13856

Department of Hematology, The First Hospital, China Medical University, Shenyang, China.

Rationale: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a small subtype of T-cell acute lymphoblastic leukemia with a typical immune-phenotype: lack of T-lineage cell surface markers CD1a and CD8 expression, weak or absent CD5 expression, at least one of the myeloid or hematopoietic stem cell markers. It is characterized by high rate of induction failure and the effective unified treatment strategies are still indeterminate. We present 2 ETP-ALL cases. Read More

Clin Case Rep 2018 Dec 26;6(12):2427-2430. Epub 2018 Oct 26.

Division of Hematology/Oncology, Department of Medicine Buffalo General Hospital Buffalo New York.

Bone marrow aspirations are used in the diagnosis of patients with hematological disorders. Cytological diagnosis becomes difficult when aspiration is a dry tap. Smears produced from the material left in the needle following a dry tap can provide valuable information either to complement or even make an accurate diagnosis. Read More

World J Clin Cases 2018 Nov;6(14):776-780

Department of General Internal Medicine, Saitama Medical University, Iruma-gun 350-0495, Saitama, Japan.

A 19-year-old female was diagnosed with ulcerative colitis when she presented with persistent melena, and has been treated with 5-aminosalicylic acid for 4 years, with additional azathioprine for 2 years at our hospital. The patient experienced high-grade fevers, chills, and cough five d prior to presenting to the outpatient unit. At first, the patient was suspected to have developed neutropenic fever; however, she was diagnosed with Epstein-Barr virus-associated hemophagocytic syndrome (EB-VAHS) upon fulfilling the diagnostic criteria after bone marrow aspiration. Read More

Nat Rev Nephrol 2019 Jan;15(1):45-59

Division of Nephrology, Hematology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

The term monoclonal gammopathy of renal significance (MGRS) was introduced by the International Kidney and Monoclonal Gammopathy Research Group (IKMG) in 2012. The IKMG met in April 2017 to refine the definition of MGRS and to update the diagnostic criteria for MGRS-related diseases. Accordingly, in this Expert Consensus Document, the IKMG redefines MGRS as a clonal proliferative disorder that produces a nephrotoxic monoclonal immunoglobulin and does not meet previously defined haematological criteria for treatment of a specific malignancy. Read More

J Pediatr Hematol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pediatric Hematology and Oncology, Kanuni Sultan Suleyman Education and Research Hospital.

Background: Burkitt leukemia (BL) with the precursor B-cell immunophenotype is a rarely reported condition. The prognosis of such patients is similar to that of classic BL. However, the combination of chromosomal translocations associated with bcl-2 and c-myc rearrangement has a poor prognosis. Read More

Aust Vet J 2018 Dec;96(12):502-507

Willows Veterinary Centre and Referral Service, Solihull, UK.

Background: The Flat-coated Retriever (FCR) is a breed at-risk for histiocytic sarcoma (HS). A haemophagocytic form of HS (HPHS) occurs in the spleen ± other sites such as bone marrow, and is a CD11d+ disease of macrophage origin. Patients with HPHS typically present with regenerative anaemia. Read More

J Assoc Physicians India 2018 May;66(5):14-6

Clinical Pharmacologist, Bangalore, Karnataka.

Aim: To evaluate the prevalence of anti-thyroid antibodies in a cohort of rheumatoid arthritis (RA) patients from south India and their clinical use.

Methods: A cross-sectional epidemiological study was conducted including 1217 patients aged more than 14 years with fever and thrombocytopenia admitted in the medical wards from October 2013 to September 2014. Detailed clinical examination and routine investigations were done; specific investigations like blood culture, widal test, antigen test for malaria, IgM ELISA leptospira, IgM ELISA dengue, bone marrow aspiration/biopsy etc. Read More

J Ayub Med Coll Abbottabad 2018 Jul-Sep;30(3):342-344

Department of Pathology, Ayub Medical College, Abbottabad, Pakistan.

Background: Visceral Leishmaniasis (Kala Azar), a vector borne parasitic disease is endemic in many parts of the world including South East Asia. It is a chronic febrile ailment caused by Leishmania Donovani (LD). More than three hundred million people living in the endemic areas are at high risk and fourteen million are living with the disease. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13161

Department of Hematology, Gui Zhou Provincial People's Hospital.

Rationale: Gaucher disease (GD), characterized by glucosylceramide accumulation in the macrophage-monocyte system, is caused by glucosidase b acid (GBA) gene mutations which lead to the deficiency of lysosomal enzyme glucocerebrosidase. The mutation spectrum of GBA in Chinese patients is quite different from those seen in Jewish and non-Jewish Caucasian patients. Thus, it is relatively hard to diagnose GD in Chinese. Read More

Int J Hematol 2019 Mar 19;109(3):361-365. Epub 2018 Nov 19.

Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Republic of Korea.

Gaucher disease (GD) is caused by a hereditary deficiency of glucocerebrosidase, resulting in accumulation of glucosylceramide and potentially manifesting as hepatosplenomegaly. We report the case of a 15-month-old boy with chronic neuronopathic GD. The patient had prolonged anemia despite continued iron supplementation for 3 months. Read More

BMC Endocr Disord 2018 Nov 19;18(1):86. Epub 2018 Nov 19.

Department of Medical Surgical and Health Sciences, Università degli Studi di Trieste, Cattinara Teaching Hospital, Strada di Fiume 447, 34149, Trieste, Italy.

Background: Thyroid lymphomas are an exceptional finding in patients with thyroid nodules. Burkitt's lymphoma is one of the rarest and most aggressive forms of thyroid lymphomas, and its prognosis depends on the earliness of medical treatment. Given the rarity of this disease, making a prompt diagnosis can be challenging. Read More

Acta Clin Croat 2018 Jun;57(2):362-365

Department of Hematology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

T-cell large granular lymphocytic leukemia (T-LGLL) is an uncommon but probably underdiagnosed disease caused by clonal proliferation of large granular lymphocytes. Diagnosis is typically based on the high number of morphologically characteristic lymphoid cells and finding of an abnormal immunophenotype by flow cytometry. Because of its relatively indolent clinical behavior, observation is often an appropriate therapy. Read More

Br J Haematol 2019 Jan 8;184(1). Epub 2018 Nov 8.

University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

J Glob Oncol 2018 11;4:1-11

Shahin Sayed, Anderson Mutuiri, Nancy Okinda, Zahir Moloo, Abubakar Abdillah, Erick Chesori, Elizabeth Kagotho, Eunida Migide, and Donstefano Muninzwa, Aga Khan University Hospital; Jamilla Rajab, Jessie Githanga, Mary Mungania, Brian Ayara, Julia Muthua, Leah Obosy, Thaddeus Massawa, Peter K. Shikuku, and Lucy Muchiri, University of Nairobi; Okoth Obiero and Andrew K. Gachii, Kenyatta National Hospital, Nairobi, Kenya; Andrew Field, Notre Dame University Medical School and St. Vincent's Hospital, Sydney, Australia; and Sanford M. Dawsey, National Cancer Institute, Bethesda, MD.

Purpose: Fine-needle aspiration biopsy (FNAB) cytology is a simple, inexpensive, and accurate diagnostic test for benign, infectious, and malignant lesions of the breast, thyroid, lymph nodes, and other organs. Similarly, bone marrow aspiration and trephine (BMAT) biopsy procedures are relatively simple and inexpensive techniques that are important for diagnosing and monitoring many hematologic diseases including leukemias and lymphomas. However, the scarcity of pathologists in Kenya limits patient access to these simple diagnostic tests. Read More

Clin Nurs Res 2018 Nov 2:1054773818807996. Epub 2018 Nov 2.

3 University of Pennsylvania School of Nursing, Philadelphia, USA.

Clinicians routinely perform bone marrow aspiration and biopsy (BMAB) to diagnose cancer and evaluate disease status; however, few studies address pain and distress with BMAB. A prospective descriptive-correlational design examined patients' ( N = 152) ratings of pain intensity (numeric rating scale, 0-10) and distress (distress thermometer) at baseline and 5 min and 1 hr postprocedure. Data were analyzed using descriptive statistics, chi-square, and linear regression models. Read More

Acta Radiol 2018 Oct 31:284185118810977. Epub 2018 Oct 31.

5 Department of Oncology, Oslo University Hospital, Oslo, Norway.

Background: Focal treatment of prostate cancer recurrence is emerging and increases the demand for precision in imaging; pure detection is no longer enough and accurate localization is needed.

Purpose: To investigate the ability of anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (FACBC) PET/CT to localize radio-recurrences within the prostate, compared to multiparametric magnetic resonance imaging (mpMRI) and with histopathology as the reference standard.

Material And Methods: This prospective salvage focal brachytherapy protocol included 20 patients (mean age = 66 years; age range = 57-72 years) with biochemical recurrence after primary radiotherapy. Read More

Oxf Med Case Reports 2018 Nov 22;2018(11):omy094. Epub 2018 Oct 22.

Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, Japan.

An 82-year-old man with a recurrence of pulmonary pleomorphic carcinoma was treated with pembrolizumab. He achieved partial response after three cycles of pembrolizumab. However, he developed febrile neutropenia. Read More

BMC Infect Dis 2018 Oct 22;18(1):528. Epub 2018 Oct 22.

Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus named SFTS virus (SFTSV), which is classified into the genus Phlebovirus and family Phenuiviridae. Reactive plasmacytosis mimicking multiple myeloma is a very rare condition in association with SFTS. Here, we describe two SFTS cases who presented with hyperimmunoglobulinemia, as well as extensive bone marrow and peripheral blood plasmacytosis, which mimicked multiple myeloma (MM). Read More

J Assoc Physicians India 2018 04;66(4):33-6

Sr. Registrar.

Objectives: Febrile thrombocytopenia is a condition commonly caused by infections. The present study is intended to know the underlying etiology of fever with thrombocytopenia, the various presentations and complications in our community.

Material And Methods: A cross-sectional epidemiological study was conducted including 1217 patients aged more than 14 years with fever and thrombocytopenia admitted in the medical wards from October 2013 to September 2014. Read More

J Clin Oncol 2018 Oct 22:JCO2018793497. Epub 2018 Oct 22.

Lucia Masarova and Srdan Verstovsek, The University of Texas MD Anderson Cancer Center, Houston, TX.

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. Read More

J Bras Nefrol 2018 Oct-Dec;40(4):423-427. Epub 2018 Oct 11.

Universidade Federal Fluminense, Niterói, RJ, Brasil.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon and life-threating condition characterized by major immune activation and massive cytokine production by mononuclear inflammatory cells, due to defects in cytotoxic lymphocyte function. It is even more unusual in renal transplant recipients, in which it is often associated with uncontrolled infection. The mortality is high in HLH and differential diagnosis with sepsis is a challenge. Read More

Front Endocrinol (Lausanne) 2018 1;9:577. Epub 2018 Oct 1.

Endocrinology of Aging Unit, Department of Medicine and Surgery, University of Parma, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.

Angiosarcoma (AS) of the thyroid is a rare and aggressive tumor. Its incidence is higher in iodine-deficient areas but cases unrelated to endemic goiter have been reported. We describe a case of a 63-year-old Italian man living in a non-iodine-deficient area, with no previous diagnosis of thyroid disease with a history of radiation exposure. Read More

Breast Cancer Res 2018 10 16;20(1):120. Epub 2018 Oct 16.

Department of Oncology, Oslo University Hospital, Oslo, Norway.

Background: The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state over time, but clinical studies of markers predicting the awakening potential of DTCs are lacking. Recently, experiments have shown that NR2F1 (COUP-TF1) plays a key role in dormancy signaling. Read More

Cancer 2018 Oct 15;124(19):3849-3855. Epub 2018 Oct 15.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: The diagnosis of chronic myeloid leukemia (CML) is based on characteristic clinical and laboratory findings and the presence of BCR/ABL1 in the blood and/or bone marrow (BM). The utility of BM core biopsy in the workup of patients with CML has been questioned.

Methods: The potential added value of BM biopsy versus aspiration in the workup of a single-institution series of 508 patients with CML at their initial presentation was systematically assessed. Read More

J Pathol Transl Med 2018 Nov 15;52(6):404-410. Epub 2018 Oct 15.

Department of Pathology, Gangnam Severance Hospital, Seoul, Korea.

Background: Fine-needle aspiration cytology serves as a safe, economical tool in evaluating thyroid nodules. However, about 30% of the samples are categorized as indeterminate. Hence, many immunocytochemistry markers have been studied, but there has not been a single outstanding marker. Read More

Medicine (Baltimore) 2018 Oct;97(41):e12701

Flow Cytometry Center, Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Rationale: Central nervous system (CNS) infiltration of Richter's syndrome (RS) is rare and only a few cases were discussed. Of these published cases, either they were accompanied with lymph node involvement or with a history of chronic lymphocytic leukemia (CLL). To our knowledge, this is the first published case of RS of the brain and meninges diagnosed concurrently with CLL in the absence of any evidence of lymphoma outside of the CNS. Read More

Asia Pac J Oncol Nurs 2018 Oct-Dec;5(4):394-398

The University of Kansas Medical Center, Kansas City, Kansas, USA.

Objective: Bone marrow biopsy is an essential component in the diagnosis of hematopoietic disorders. Researchers evaluated the quality of bone marrow biopsy tissue acquired with a motorized bone marrow biopsy device versus a standard manual device based on the following criteria: biopsy length, percentage of aspiration artifact/intrastromal hemorrhage, length of nonhematopoietic bone, and overall quality of the sample.

Methods: Bone marrow biopsies (motorized, = 30; manual, = 120) from two academic medical centers were evaluated by two board-certified hematopathologists. Read More

Ann Hematol 2019 Jan 25;98(1):67-72. Epub 2018 Sep 25.

Division of Hemathology in Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Various infectious diseases can hyper-stimulate the immune system, causing hemophagocytic syndrome (HPS). Little is known regarding the accuracy of diagnostic criteria and epidemiological triggering factors in the acquired immunodeficiency syndrome (AIDS) setting. We investigated the major infectious disease triggers of HPS in patients living with human immunodeficiency virus (HIV)/AIDS and determined the accuracy of bone marrow aspiration (BMA). Read More

J Glob Oncol 2018 Sep 7;4:1-7. Epub 2017 Dec 7.

Nathan R. Brand, Consultant for Leidos Biomedical, Frederick; Nicholas Wolf and John Flanigan, National Cancer Institute, Bethesda, MD; Nathan R. Brand, Columbia University College of Physicians and Surgeons, New York, NY; Richard Njoroge and Alfred Karagu, Ministry of Health; and Alfred Karagu, National Cancer Institute of Kenya, Nairobi, Kenya.

Purpose: Histology and cytopathology services are necessary for cancer diagnosis and treatment. However, the current capacity of Kenya's pathology laboratories is unknown. A national survey was conducted among public sector pathology laboratories to assess their capacity to perform histology, fine-needle aspiration, and bone marrow aspiration. Read More

Vet Clin Pathol 2018 Dec 19;47(4):643-648. Epub 2018 Sep 19.

Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon.

A 9-year-old spayed female Curly Coated Retriever was referred for evaluation of generalized peripheral lymphadenomegaly. The dog was clinically healthy on presentation with no anomalies detected on complete blood count, serum biochemistry, urinalysis, or three-view thoracic radiographs. Fine-needle aspiration (FNA) and cytology of the peripheral lymph nodes were consistent with lymphoma with an intermediate-sized lymphoid population. Read More

Mayo Clin Proc Innov Qual Outcomes 2018 Mar 11;2(1):26-29. Epub 2017 Dec 11.

Department of Anesthesiology, Mayo Clinic, Rochester, MN.

Objective: To determine the risks and outcomes of providing sedation to febrile patients scheduled for bone marrow aspiration or biopsy procedures.

Patients And Methods: During the 4-year period from January 1, 2013, through December 31, 2016, data from the periprocedural courses of 12,134 consecutive patients in an outpatient procedure center at a large tertiary medical center were collected retrospectively and analyzed to determine whether febrile patients undergoing bone marrow aspiration and/or biopsy with propofol sedation present a unique patient safety risk.

Results: Eighty-four patients (0. Read More

Stem Cell Res Ther 2018 09 14;9(1):235. Epub 2018 Sep 14.

Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino-IRCCS, Via Carlo Parea 4, 20138, Milan, Italy.

Background: Cell therapy with bone marrow (BM)-derived progenitors has emerged as a promising therapeutic for refractory angina (RA) patients. In the present study, we evaluated the safety and preliminary efficacy of transcatheter delivery of autologous BM-derived advanced therapy medicinal product CD133 cells (ATMP-CD133) in RA patients, correlating perfusion outcome with cell function.

Methods: In the phase I "Endocavitary Injection of Bone Marrow Derived CD133 Cells in Ischemic Refractory Cardiomyopathy" (RECARDIO) trial, a total of 10 patients with left ventricular (LV) dysfunction (ejection fraction ≤ 45%) and evidence of reversible ischemia, as assessed by single-photon emission computed tomography (SPECT), underwent BM aspiration and fluoroscopy-based percutaneous endomyocardial delivery of ATMP-CD133. Read More

Hematol Oncol Clin North Am 2018 10 23;32(5):811-820. Epub 2018 Jul 23.

Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Mayer 221, Boston, MA 02215, USA.

The initial evaluation of the patient with Waldenström macroglobulinemia can be challenging. Not only is it a rare disease, but the clinical features can vary greatly from patient to patient. In this article, we aim at providing concise and practical recommendations for the initial evaluation of patients with Waldenström macroglobulinemia, specifically regarding history taking, physical examination, laboratory testing, bone marrow aspiration, and biopsy evaluation and imaging studies. Read More