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Trop Doct 2021 May 12:494755211002027. Epub 2021 May 12.

Post Graduate Resident, Department of Pathology, 28856Lady Hardinge Medical College, New Delhi, India.

Extra-lymphatic manifestation of filariasis, especially as acute renal failure, is uncommon and may be clinically unsuspected. We document the case of a 60 year old elderly male who presented with bilateral pedal oedema, fatigue and abdominal distension. Investigations revealed severe anaemia, splenomegaly and acute renal failure. Read More

Turk Patoloji Derg 2021 ;37(2):145-153

Department of Pathology, Krishna Institute of Medical Sciences (Deemed to University), MAHARASHTRA, INDIA.

Objective: Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) are clinically and biologically diverse phenotypic diseases amongst hematological malignancies. The current study objectives were to diagnose and classify cases of AL as per revised 4th edition of WHO 2016 classification of AL's and study their clinicopathological profiles.

Material And Method: This cross-sectional, observational study included 68 patients, diagnosed with AL were recruited. Read More

Autops Case Rep 2021 Apr 20;11:e2021274. Epub 2021 Apr 20.

Harbor-UCLA Medical Center, Department of Internal Medicine, Torrance, CA, USA.

Background: Myelodysplastic syndromes (MDS) mainly occur in the elderly but can rarely affect younger individuals too. The correct diagnosis relies on careful morphologic evaluation, cytogenetic/molecular results, and excluding reactive conditions mimicking MDS. We present the clinical, pathologic, cytogenetic, and molecular features of a case of MDS with excess blasts-2 (MDS-EB-2) in a 30-year-old male who was found to have pancytopenia during his hospitalization for coronavirus disease 2019 (COVID-19) and discuss the diagnostic challenges of MDS in patients with COVID-19. Read More

Front Immunol 2021 21;12:669723. Epub 2021 Apr 21.

Infectious Diseases Department, Caen University Hospital, Caen, France.

We report a case of a severe visceral leishmaniasis revealing an HIV-1 infection presenting as an acute primary infection. A young French man living in Paris with history of unprotected sex with a recent male partner and recent travel in Greece was admitted in our Infectious Diseases Department, presenting with acute febrile psychotic disorder, and positive HIV-1 serology with high viral load, very low CD4 T-cells count and a western blot pattern suggesting an acute infection. The psychotic disorder was finally related to hemophagocytic lymphohistiocytosis diagnosed on bone marrow aspiration, supposedly secondary to HIV acute primary infection. Read More

Rinsho Ketsueki 2021 ;62(4):245-250

Department of Hematology/Oncology, Konan Kosei Hospital.

Acute myeloid leukemia (AML) associated with double-minute chromosomes (dmin) is a rare condition and has a poor prognosis. A 68-year-old man with leukocytosis and thrombocytopenia was admitted to our hospital. Bone marrow aspiration showed that 79. Read More

Cancer Treat Res Commun 2021 Apr 25;28:100380. Epub 2021 Apr 25.

Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Multiple myeloma (MM), is a heterogeneous disease in which chromosomal abnormalities are important for prognostic risk stratification. Cytogenetic profiling with FISH on plasma cells from bone marrow samples (BM-PCs) is the current gold standard, but variable infiltration of plasma cells or failed aspiration can hamper this process. Ultra-low coverage sequencing (ULCS) of circulating cell-free DNA (ccfDNA) may offer a minimally invasive alternative for the work-up of these cases. Read More

Arq Bras Cardiol 2021 Mar;116(3):395-401

Health Sciences University, Adana Research and Training Hospital - Department of Cardiology, Adana - Turquia.

Background: Hemophagocytic syndrome (HPS) ia s devastating hyperinflammatory syndrome. Heart failure (HF) with preserved ejection fraction (HFpEF) status is closely correlated with increased inflammation, both systemic and intramyocardial.

Objectives: This study sought to determine mortality predictors and reliable follow-up parameters in HPS that developed HFpEF during the clinical course. Read More

BMJ Case Rep 2021 Apr 22;14(4). Epub 2021 Apr 22.

Allergy and Clinical Immunology Department, Hospital and University Centre of Coimbra, Coimbra, Portugal.

A 57-year-old man with lumbar pain and fever was diagnosed with spondylodiscitis. Afterward, he acquired full paraplegia. Image studies showed a mass extending from D9 to the vertebral canal, plus numerous adjacent osteolytic lesions. Read More

Medicine (Baltimore) 2021 Apr;100(16):e25518

Department of Medicine, Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University.

Introduction: Acquired hemophilia A (AHA) is a rare bleeding disorder caused by autoantibodies against factor VIII (FVIII). Hematological malignancies, especially lymphoid malignancies, are known to be underlying causes of AHA; however, thus far, there is no report of AHA associated with Epstein-Barr-virus-associated T/natural killer-cell lymphoproliferative disease (EBV-T/NK-LPD). Here, we present a case of AHA that developed during treatment for EBV-T/NK-LPD. Read More

Medicine (Baltimore) 2021 Apr;100(15):e25528

Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Hematology of Nanjing Medical University.

Rationale: Pure erythroid leukemia is a rare subcategory of acute myeloid leukemia characterized by predominant immature erythroid population. Its occurrence subsequent to acute myelomonocytic leukemia has not been reported before. We reported this rare case to call attention because it may pose a diagnostic challenge. Read More

Cytometry A 2021 Apr 12. Epub 2021 Apr 12.

Department of Pathology Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.

Fluorescence lifetime imaging (FLIM) has been used in living cells to measure metabolic activity and demonstrate cell differentiation. The aim of this study was to investigate whether the FLIM technique could be able to demonstrate cell maturation during myelopoiesis and erythropoiesis in unlabeled routine bone marrow (BM) preparations. Air-dried, unstained smears of BM aspiration samples of 32 patients without BM disease and a normal morphology on May-Grünwald-Giemsa (MGG) stained smears entered the study. Read More

Indian J Tuberc 2021 Apr 12;68(2):201-204. Epub 2020 Aug 12.

Dept. of Pathology, BSMCH, Kenduadihi, Bankura, 722102, West Bengal, India. Electronic address:

Background: Tuberculosis remains a major public health problem in various parts of the world. It leads to various haematological changes. Study of these haematological changes will help better patient management. Read More

Case Rep Infect Dis 2021 31;2021:6629966. Epub 2021 Mar 31.

Pediatric Department, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Similarities in the febrile course and other manifestations of some diseases may lead to clinical misdiagnosis of COVID-19 infection. Here, we report a case in a young child with a potentially confusing clinical course. . Read More

Medicine (Baltimore) 2021 Apr;100(13):e24567

Department of Hematology, Zhengzhou University People's Hospital.

Rationale: Acute promyelocytic leukemia (APL) with myelofibrosis (MF) is rare, and only 14 cases have been reported in the literature to date.

Patient Concerns: A 42-year-old woman was admitted to the hospital with easy bruising and excessive bleeding. With the remission of the primary disease during treatment, the degree of fibrosis did not decrease, but worsened progressively. Read More

Clin Case Rep 2021 Mar 18;9(3):1483-1489. Epub 2021 Jan 18.

Department of Gastroenterology and Hematology Hirosaki University Graduate School of Medicine Hirosaki Japan.

A 66-year-old man presented with worsening dyspnea. A colonoscopy revealed an elevated lesion at the rectosigmoid junction. The biopsy specimen and bone marrow aspiration demonstrated adenocarcinoma, leading to a diagnosis of disseminated carcinomatosis of the bone marrow. Read More

Diagn Cytopathol 2021 Mar 22. Epub 2021 Mar 22.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

Myeloid sarcoma (MS) is a mass-forming, extramedullary infiltration of myeloid blasts rarely presenting in cases of acute myeloid leukemia (AML). These tumoral masses rarely occur at any and multiple anatomic sites, precedent or coincident with bone marrow evidence of AML. We report a case of MS that presented as pancreatic and cardiac masses where subsequent evaluation of pleural effusion cytology rendered the diagnosis. Read More

J Pediatr Surg 2021 Feb 24. Epub 2021 Feb 24.

Department of Surgery, Division of Pediatric Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, FB Suite 6B.1, 700 Children's Drive, Columbus, OH, United States. Electronic address:

Background/purpose: Thyroid Imaging Reporting and Data System (TI-RADS) is validated in adults but not yet in children. The purpose of this study was to determine the sensitivity, specificity, and accuracy of TI-RADS in predicting thyroid malignancy for pediatric nodules, and to compare the diagnostic accuracy to the current American Thyroid Association (ATA) guidelines.

Methods: A single institution retrospective review was performed of patients younger than 21 years who underwent thyroid nodule fine needle aspiration biopsy (FNAB). Read More

Pathology 2021 Mar 18. Epub 2021 Mar 18.

Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; College of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. Electronic address:

The blast percentage in bone marrow (BM) can be evaluated through biopsy and aspiration, which is essential for diagnosing myeloid neoplasms especially for dividing myelodysplastic syndrome (MDS)/acute myeloid leukaemia (AML). However, methods for integrating the results of biopsy and smear have yet to be developed, particularly for cases in which the results fall on both sides of the cut-off value (10% or 20%). We studied 188 cases of MDS/AML initially diagnosed during 2011-2015 by using concomitant BM biopsy and aspiration and used different methods to compare the estimated blast percentages. Read More

J Cancer Res Ther 2021 Jan-Mar;17(1):282-287

Department of Haematology, Faculty of Medicine, Trakya University, Edirne, Turkey.

The genetic characterization of chronic lymphocytic leukemia (CLL) has made significant progress over the past few years. Chromosomal abnormalities are detected in up to 80% of patients. Determination of new chromosomal disorders is important in the pathogenesis and treatment facilities. Read More

Indian J Hematol Blood Transfus 2021 Jan 20;37(1):108-118. Epub 2020 Jul 20.

Department of Pathology, Christian Medical College & Hospital, Ludhiana, Punjab 141008 India.

Bone marrow examination entails study of aspirate smears, touch imprints and trephine biopsy. Bone marrow aspirate smears can be prepared by the squash (crush) or wedge method. Both techniques have their own advantages and disadvantages. Read More

Exp Ther Med 2021 Apr 25;21(4):404. Epub 2021 Feb 25.

Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China.

Systemic mastocytosis (SM) is a heterogeneous disease of the bone marrow, which is characterized by the abnormal proliferation and infiltration of mast cells in one or more organs, such as the skin, bone marrow, digestive tract, liver and spleen. Urticaria pigmentosa is a typical but infrequent manifestation of SM. Other clinical presentations are non-specific, varying from pruritus and hypotension to multiple organ dysfunction, which may be lethal when hemodynamic changes occur, such as the sharp decline in blood pressure observed in the present case. Read More

J Clin Exp Hepatol 2021 Jan-Feb;11(1):149-153. Epub 2020 May 22.

Department of Gastroenetrology, All India Institute of Medical Sciences, New Delhi, India.

Hemophagocytic lymphohistiocytosis is a life-threatening disorder characterized by persistent pathologic activation of cytotoxic T lymphocytes, natural killer cells, and macrophages. We present details of a young patient who presented with high-grade fever, jaundice, and breathlessness. On investigations, he had hepatitis, anemia, neutropenia, and coagulopathy. Read More

Zhonghua Xue Ye Xue Za Zhi 2021 Jan;42(1):58-62

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Regenerative Medicine Clinic, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

To explore the diagnostic process and outcomes of patients with aplastic anemia (AA) who received outpatient treatment in a real-world setting. The diagnostic processes, treatment regimens, and outcomes of 176 patients with AA treated in outpatient centers from January 2018 to December 2019 were reviewed. The median interval from the onset of symptoms to the first visit was 7 (5-120) months. Read More

CEN Case Rep 2021 Mar 5. Epub 2021 Mar 5.

Department of Rheumatology, Chubu Rosai Hospital, 2-10-15, Komei-cho, Minato-ku, Nagoya, Aichi, 455-8530, Japan.

We herein report a case of a combined crystalline light chain tubulopathy, podocytopathy, histiocytosis, and cast nephropathy in a patient with monoclonal gammopathy of renal significance (MGRS). A 66-year-old female with impaired renal function was referred to our department. Despite intravenous fluid resuscitation, the kidney function worsened progressively; thus, a kidney biopsy was performed. Read More

BMC Res Notes 2021 Mar 4;14(1):84. Epub 2021 Mar 4.

Bassett Medical Center, One Atwell Road, Cooperstown, NY, 13326, USA.

Objective: The purpose of this study was to compare the charges and payments associated with bone marrow aspiration and biopsies performed by hematology/oncology specialists versus interventional radiology specialists at Bassett Medical Center located in a rural area of New York State. Charges pertained to what the hospital charged for the procedure and payment refers to the reimbursement the hospital received. Our secondary objectives were to compare specimen quality by procedure and to determine whether body mass index was associated with which specialist performed the procedure. Read More

Medicine (Baltimore) 2021 Feb;100(8):e24802

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education.

Rationale: Clitoris swelling as the initial clinical presentation of acute lymphoblastic leukemia (ALL) is extremely rare. These patients may be misdiagnosed with acute myeloid leukemia or solid tumor, and the main treatment can also be delayed.

Patient Concerns: A 2. Read More

Medicine (Baltimore) 2021 Feb;100(8):e24707

Department of Hematology, Chinese PLA General Hospital.

Introduction: Myeloid neoplasms with platelet-derived growth factor receptor β (PDGFRB) rearrangement usually present with eosinophilia in the peripheral blood and bone marrow. Here we report a case of systemic mastocytosis related myeloid neoplasms with basophilia and PRKG2-PDGFRB fusion gene.

Patients Concerns: A 53-year-old male patient felt fatigue with thrombocythemia and normal hemoglobin over 2 years. Read More

Clin Orthop Relat Res 2021 Feb 26. Epub 2021 Feb 26.

A. Aryal, V. S. Kumar, S. A. Khan, Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

Background: Skeletal metastases of bone sarcomas are indicators of poor prognosis. Various imaging modalities are available for their identification, which include bone scan, positron emission tomography/CT scan, MRI, and bone marrow aspiration/biopsy. However, there is considerable ambiguity regarding the best imaging modality to detect skeletal metastases. Read More

World J Surg Oncol 2021 Feb 24;19(1):61. Epub 2021 Feb 24.

Department of Surgical Oncology, Institute of Medical Science, Banaras Hindu University, Varanasi, 221005, India.

Introduction: Isolated primary sacral diffuse large B cell non-Hodgkin's lymphoma is a very rare entity, and only 11 cases have been reported previously.

Case Presentation: A 36-year-old man was referred with low backache and radiculopathy pain with a clinico-radiological and cytological diagnosis of sacral metastasis. Histopathological examination and immunohistochemistry of image-guided tissue core biopsy from the sacral mass confirmed it as high-grade diffuse large B cell lymphoma (DLBCL). Read More

Curr Probl Cancer 2021 Jan 8:100703. Epub 2021 Jan 8.

Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Retinoblastoma (RB) is the most common primary intraocular malignancy of childhood. Recurrence of RB often occurs within 6 months to 1 year after the end of treatment. Orbital tissue is the most common site of recurrence in children who have undergone enucleation; other sites include the central nervous system, bone, bone marrow, lymph nodes, and other organs. Read More