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Front Oncol 2022 6;12:824393. Epub 2022 May 6.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.

Background: T-cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder that starts in T cells and is usually indolent. Long-term use of immunosuppressants, combined with agranulocytosis, is a double-edged sword, as both can lead to serious infections, especially in patients with combined hematologic malignancies and immune defects.

Case Presentation: A 30-year-old female patient was admitted to the hospital because of agranulocytosis for five years, with chest tightness, fatigue, and fever for two days. Read More

Eat Weight Disord 2022 May 12. Epub 2022 May 12.

Nephrology Department, Hospital Universitari de Girona Doctor Josep Trueta, Avinguda de França S/N, 17007, Girona, Spain.

Background: Anorexia nervosa is frequently associated with alcohol use disorder. Both of them may adversely affect almost every body system, leading to worse clinical outcomes and high mortality risk. Nonetheless, there is little evidence interrelating anorexia nervosa, alcohol use disorder, and kidney failure. Read More

Brain Tumor Res Treat 2022 Apr;10(2):113-116

Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.

Peripheral scalp T-cell lymphoma is a very rare disease. We report a case of a 22-year-old man who presented an indolent large scalp mass in the right frontal scalp region. The patient's physical examination demonstrated no palpable mass in the chest, abdomen, and extremities. Read More

BJU Int 2022 May 10. Epub 2022 May 10.

Institute of Andrology, University College London Hospitals NHS Foundation Trust, London, UK.

Objectives: To demonstrate that surgical sperm retrieval (SSR) and spermatogonial stem cell retrieval (SSCR) in oncological context are safe and successful.

Subjects/patients And Methods: This a retrospective study in a tertiary hospital in the UK. Patients requiring fertility preservation from December 2017 to January 2020 were included. Read More

J Int Med Res 2022 Apr;50(4):3000605221096161

Department of Orthopaedic Surgery, People's Hospital of Yichun City, Jiangxi Province, P.R. China.

Waldenstrom's macroglobulinemia (WM) is a rare type of malignant B-cell lymphoma. The main feature of WM is elevated serum monoclonal immunoglobulin M, similar to multiple myeloma (MM). Unlike in MM, the rarity of destructive bone lesions in WM has been repeatedly emphasized. Read More

Lancet Haematol 2022 May;9(5):e350-e360

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Venetoclax combined with intensive chemotherapy has been shown to be safe with promising activity in fit patients with newly diagnosed acute myeloid leukaemia. The aim of this study was to compare the activity of venetoclax plus intensive chemotherapy with intensive chemotherapy alone.

Methods: This was a post-hoc propensity score matched analysis of prospective clinical trials (NCT03214562, NCT02115295, and NCT01289457) in patients at The University of Texas MD Anderson Cancer Center, Texas, USA between March 29, 2010, and June 15, 2021. Read More

Rev Esp Enferm Dig 2022 Apr 26. Epub 2022 Apr 26.

Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, España.

A 71-year-old woman diagnosed with type II diabetes mellitus with severe iron deficiency anemia and positive fecal occult blood. Colonoscopy was performed, showing a soft mass (figure A) in the ascending colon, with biopsies compatible with plasmacytoma and restriction for Kappa light chains (figure C and D). After bone marrow aspiration, associated IgG multiple myeloma was detected, so chemotherapy with VMP (Bortezomib, Melphalan and Prednisone) was started. Read More

Vaccines (Basel) 2022 Apr 8;10(4). Epub 2022 Apr 8.

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City 704, Taiwan.

Although serious adverse events have remained uncommon, cases of myocarditis induced by messenger RNA (mRNA) COVID-19 vaccines have been reported. Here, we presented a rare but potentially fatal disorder, hemophagocytic lymphohistiocytosis, in a 14-year-old previously healthy adolescent after BNT162b2 mRNA vaccination. The initial evaluation showed splenomegaly, pancytopenia, hyperferritinemia, and hypofibrinogenemia. Read More

Thyroid Res 2022 Apr 20;15(1). Epub 2022 Apr 20.

Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL, USA.

Background: Amyloid goiter, defined as excess amyloid within the thyroid gland in such quantities that it produces a clinically apparent goiter, is a very rare manifestation of systemic amyloidosis with cases commonly seen in the setting of Amyloid A (AA) amyloidosis. Amyloid goiter as the primary clinical manifestation secondary to Amyloid light chain (AL) amyloidosis is very rare. We present a case of AL amyloidosis with initial manifestation as goiter with amyloid deposition in the thyroid and the parathyroid gland. Read More

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):387-391

Department of Pediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi, India.

Background: Neuroblastoma (NB) is the fourth most common tumor of childhood. There is a paucity of literature on its subtyping of cytology and prognostic utility.

Aims: We aimed to study the cytopathological features of NB on the aspirated material, subtype it, and assess the role of International Neuroblastoma Pathology Classification (INPC) classification on cytology smears in the preoperative prognosis of NB. Read More

Diagnostics (Basel) 2022 Mar 3;12(3). Epub 2022 Mar 3.

Laboratory of Molecular Genetics, Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, SB RAS, 630090 Novosibirsk, Russia.

Non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of malignant lymphomas that can occur in both lymph nodes and extranodal sites. Bone marrow (BM) is the most common site of extranodal involvement in NHL. The objective of this study is to determine the unique profile of miRNA expression in BM affected by NHL, with the possibility of a differential diagnosis of NHL from reactive BM changes and acute leukemia (AL). Read More

Turk J Pediatr 2022 ;64(1):152-159

Departments of Pediatric Hematology and Oncology, İstanbul University Faculty of Medicine, İstanbul, Turkey.

Background: Granulocytic sarcoma (GS) is an extramedullary solid tumor composed of immature myeloid cells. GS has been associated with acute myeloid leukemia (AML), myelodysplastic syndromes or myeloproliferative diseases. Although GS can affect various tissues of the human body, it has rarely been reported in other soft tissues such as the breast, gastrointestinal, respiratory and genitourinary tracts. Read More

Zhonghua Jie He He Hu Xi Za Zhi 2022 Mar;45(3):289-292

Department of Lung Transplantation, China-Japan Friendship Hospital; National Center for Respiratory Medicine; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Beijing 100029, China.

Lymphoma after solid organ transplantation is one of the manifestations of post-transplant lymphoproliferative disorders(PTLD). Here we reported a 39-year-old male patient presented with intermittent fever, markedly elevated level of peripheral blood lymphocytes and lactate dehydrogenase(LDH), rapid decrease in hemoglobin and platelet count ten months after bilateral lung transplantation. After systematic evaluation, the patient excluded infectious diseases. Read More

Cureus 2022 Feb 3;14(2):e21863. Epub 2022 Feb 3.

Pediatric Radiology, Nemours Children's Hospital, Orlando, USA.

Rhabdomyosarcoma is a highly aggressive cancer that is generally considered a disease of childhood. A vast majority of cases occur in those below the age of 20. Rhabdomyosarcoma can occur in any soft tissue in the body but is primarily found in the head, neck, orbit, genitourinary tract, genitals, and extremities. Read More

Int J Mol Sci 2022 Feb 9;23(4). Epub 2022 Feb 9.

Department of Public Health and Paediatrics, University of Torino, 10126 Torino, Italy.

The cyclic regeneration of human endometrium is guaranteed by the proliferative capacity of endometrial mesenchymal stromal cells (E-MSCs). Due to this, the autologous infusion of E-MSCs has been proposed to support endometrial growth in a wide range of gynecological diseases. We aimed to compare two different endometrial sampling methods, surgical curettage and vacuum aspiration biopsy random assay (VABRA), and to validate a novel xeno-free method to culture human E-MSCs. Read More

JNMA J Nepal Med Assoc 2021 Nov 15;59(243):1182-1184. Epub 2021 Nov 15.

Department of Pediatrics, Kanti Children's Hospital, Maharajganj, Kathmandu, Nepal.

Vitamin B12 deficiency in children can cause megaloblastic anemia, poor growth, and increased chances of infections. It is an important reversible cause of bone marrow suppression which at the time of presentation can mimic hematological malignancy. Therefore, it should be considered as a differential diagnosis in cases suspected of acute leukemia. Read More

Afr J Lab Med 2022 31;11(1):1355. Epub 2022 Jan 31.

Department of Paediatric Oncology, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: A rare entity of a B-cell malignancy with precursor B-cell phenotype and concomitant translocation t(8;14) or variant MYC translocation exists. These cases show clinical, pathological and molecular overlap between precursor B-lymphoblastic leukaemia or lymphoma and Burkitt leukaemia or lymphoma (BLL).

Case Presentation: We report a case from February 2019 at the Charlotte Maxeke Johannesburg Academic Hospital, South Africa, of a 9-month-old infant with a predominantly extracranial soft tissue mass showing extradural extension. Read More

Cureus 2022 Jan 5;14(1):e20955. Epub 2022 Jan 5.

Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.

Morphea is a rare skin condition characterized by erythematous or violaceous lesions as well as sclerotic plaques. Patients with morphea frequently have other autoimmune disorders. Contributing factors are thought to be autoimmunity and an increase in extracellular matrix production. Read More

Indian J Hematol Blood Transfus 2022 Jan 6;38(1):8-14. Epub 2021 Mar 6.

Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, India.

To analyze the pathological findings in patients with marrow metastasis from solid tumors and to compare the accuracy of the bone marrow aspirate, trephine imprint and trephine biopsy in detecting metastasis. A total number of 174 cases diagnosed on bone marrow aspiration and/or bone marrow biopsy from January 2000 to December 2018 were included in the study. In addition to clinical and demographic data, we evaluated peripheral blood findings, and pattern as well as morphology of the tumor cells in bone marrow aspirate, imprint cytology and biopsy. Read More

BMC Cancer 2022 Feb 5;22(1):147. Epub 2022 Feb 5.

Department of Haematology, Aalborg University Hospital, Forskningens Hus, Søndre Skovvej 15, DK-9000, Aalborg, Denmark.

Background: Multiple myeloma remains an incurable disease with multiple relapses due to residual myeloma cells in the bone marrow of patients after therapy. Presence of small number of cancer cells in the body after cancer treatment, called minimal residual disease, has been shown to be prognostic for progression-free and overall survival. However, for multiple myeloma, it is unclear whether patients attaining minimal residual disease negativity may be candidates for treatment discontinuation. Read More

Transl Cancer Res 2021 Mar;10(3):1603-1608

Department of Pathology, Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Xi'an Jiaotong University Health Science Center, Xi'an, China.

T-lymphoblastic lymphoma (T-LBL) is a highly aggressive malignancy originating from T-lymphocyte precursors. Incidence is highest in children and adolescents. T-cell receptor () gene rearrangement is usually present. Read More

Acta Biomed 2022 01 19;92(6):e2021430. Epub 2022 Jan 19.

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Unifocal Langerhans cell histiocytosis (LCH) presents as a solitary focal bone lesion characterized by clonal proliferation of CD1a (+) and langerin(+) dendritic cells, derived from the bone marrow. In 38-69% of cases BRAF-V600E mutation is revealed. It gains attention to maxillofacial surgeons due to involvement of the orofacial region and early onset of jaws symptoms. Read More

J Clin Exp Hepatol 2022 Jan-Feb;12(1):80-88. Epub 2021 Apr 2.

Asian Institute of Gastroenterology, Hyderabad, India.

Background: Haematopoietic stem cell (HSC) infusion has demonstrated short-term improvement in liver functions in patients with chronic liver disease. The combination of HSC with mesenchymal stem cells (MSCs), which has an immunomodulatory effect, may augment the effects and enhance the duration of improvements on liver functions. The aim of the present study was to assess the safety of infusing the combination of autologous HSCs and MSCs in decompensated liver cirrhosis. Read More

Medicina (Kaunas) 2022 Jan 16;58(1). Epub 2022 Jan 16.

Department of Surgery, Division of Colon and Rectal Surgery, Songshan Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.

Plasma cell neoplasms are characterized by dysregulated proliferation of mature B cells, which can present with either single (solitary plasmacytoma) or systemic (multiple myeloma (MM)) involvement. MM with extramedullary plasmacytoma (EMP) is a rare disease that accounts for approximately 3-5% of all plasmacytomas. EMP with gastrointestinal (GI) system involvement is an even rarer entity, accounting for <1% of MM cases. Read More

J Int Med Res 2022 Jan;50(1):3000605211072801

Department of Respiratory, Qinghai University Affiliated Hospital, Xining, China.

Pulmonary embolism and splenic infarction are rare in patients with polycythemia vera. We herein describe a man in his early 60s whose main symptoms were chest tightness, cough, and sputum expectoration. Antibiotics, bronchodilators, and mucoactive agents did not improve his symptoms. Read More

Cureus 2021 Dec 3;13(12):e20148. Epub 2021 Dec 3.

Department of Pathology, Cheikh Khalifa International University Hospital, Casablanca, MAR.

Primary plasma cell leukemia (PCL) is a rare and aggressive hematological malignancy exhibiting a circulating plasma cell count exceeding 20% of peripheral blood leukocytes or an absolute plasma cell count >2000/mm3. We report a case of a 37-year-old woman presented to the Department of Hematology with a two-month history of growth inside the oral cavity in the upper jaw and weakness. The physical examination revealed a voluminous mass involving the left side of the maxillary gingiva. Read More

Ann Med Surg (Lond) 2022 Jan 21;73:103196. Epub 2021 Dec 21.

Department of Pediatrics, Aleppo University Hospital, University of Aleppo, Syria.

Introduction: and importance: Brucellosis is a common infection in Mediterranean region that manifests with various symptoms. Brucellosis should be considered as a possible cause of recurrent fever even if the symptoms are not suggestive of brucellosis.

Case Presentation: We report a case of 10-year-old child with no significant past medical history who presented with a 4-day period peripheral edema and ascites without fever, arthralgia or abdominal pain. Read More

Mymensingh Med J 2022 Jan;31(1):24-30

Dr Muhammad Ashraf Hosen, Junior Consultant (Medicine), Upazila Health Complex, Madhupur, Tangail, Bangladesh; E-mail:

Lymphadenopathy is a common problem encountered in day to day clinical practices in Bangladesh. It is an abnormal increase in size and/or altered consistency of lymph nodes. The condition generally is not a disease itself but a symptom of one of many possible underlying problems. Read More

Cureus 2021 Dec 26;13(12):e20713. Epub 2021 Dec 26.

Department of Medicine, University of Utah, School of Medicine, Salt Lake City, USA.

Felty syndrome (FS) and infective endocarditis (IE) can present with similar signs and symptoms. FS is a diagnosis of exclusion, which poses a challenge for the clinician since accurate diagnosis is required to treat this condition effectively. A 52-year-old woman with a 15-year history of rheumatoid arthritis (RA) was admitted due to dyspnea and pain in the right ankle and left arm for two weeks. Read More

South Asian J Cancer 2021 Sep 11;10(3):190-194. Epub 2021 Nov 11.

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, India.

Bone marrow aspiration although being a common procedure is associated with significant pain and its reduction remains an unmet need. We evaluated the use of tramadol and eutectic mixture of local anesthetics (prilocaine plus lignocaine) (EMLA) for reducing the severity of pain. In this pilot study, we compared the addition of either tramadol 50 mg per oral (T) or EMLA local application (E) or no intervention (L) in addition to the usual procedure of local infiltration with lignocaine 2% before bone marrow aspiration and biopsy (BMAB) in adults suspected/confirmed with malignancy. Read More