15,377 results match your criteria Bone Island

Parallelogram flap versus homodigital island flap in the treatment of fingertip defects with bone exposure: a prospective controlled study.

J Orthop Surg Res 2022 Jun 21;17(1):326. Epub 2022 Jun 21.

Department of Orthopaedic Surgery, Jinshan Hospital of Fudan University, Longhang Road 1508, Shanghai, 201508, People's Republic of China.

Purpose: A modified local transposition flap (we call it "parallelogram flap") surgery was performed for fingertip injuries. This study aimed to compare the clinical effects of parallelogram flap and homodigital island flaps in fingertip reconstruction.

Methods: The study collected patients who underwent parallelogram transposition flaps and homodigital island flaps to repair fingertip defects from 2019 to 2021. Read More

View Article and Full-Text PDF

Expansion and consolidation of fracture liaison service in New Zealand public healthcare setting - Waitematā District Health Board Experience.

N Z Med J 2022 Jun 10;135(1556):73-80. Epub 2022 Jun 10.

Endocrinologist & General Physician, Department of Endocrinology, Waitematā District Health Board, Auckland, New Zealand.

Aim: To describe the service delivery of the Fracture Liaison Service (FLS) at Waitematā District Health Board (WDHB) for the year 2020, and to outline how the service evolved in recent years.

Method: We reviewed and analysed the WDHB FLS database as well as 4-month and 12-month patient follow-up records from the calendar year 2020.

Results: In 2020, we identified and assessed 1,225 patients. Read More

View Article and Full-Text PDF

A broken neck: outcomes from conservative management of C2 fractures in older adults.

N Z Med J 2021 12 17;134(1547):93-101. Epub 2021 Dec 17.

Geriatrician, Canterbury District Health Board.

Aim: To describe the management, complications and functional outcomes of older patients who sustain fractures of the second cervical vertebra (C2).

Methods: Retrospective review of consecutive patients aged 65 years and older. All patients admitted with the clinical discharge code of S12. Read More

View Article and Full-Text PDF
December 2021

A Japanese case of castration-resistant prostate cancer with BRCA2 and RB1 co-loss and TP53 mutation: a case report.

BMC Med Genomics 2022 Jun 20;15(1):138. Epub 2022 Jun 20.

Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Abnormalities in homologous recombination contribute to the aggressive nature of castration-resistant prostate cancer. Retinoblastoma transcriptional corepressor 1 (RB1) and breast cancer 2 (BRCA2) exist close to each other in the same chromosome, and the significance of their concurrent loss has become a hot topic in the field of cancer research.

Case Presentation: A 61-year-old man presented with a chief complaint of a mass on his head and was diagnosed as multiple bone metastases from prostate cancer. Read More

View Article and Full-Text PDF

Web Exclusive. Annals On Call - Time for a Bisphosphonate Holiday?

Ann Intern Med 2022 06;175(6):OC1

Brown University School of Public Health, Providence, Rhode Island, and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada (K.N.H.).

View Article and Full-Text PDF

Association of leukocyte nadir with complete remission in Indonesian acute myeloid leukemia patients undergoing 7+3 remission induction chemotherapy.

F1000Res 2022 5;11:495. Epub 2022 May 5.

Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Central Jakarta, Greater Jakarta, 10430, Indonesia.

: The 7+3 regimen is still the main choice of remission induction chemotherapy in acute myeloid leukemia (AML). Successfully achieving complete remission (CR) and the time required to achieve it determine patient's survival. Hence, bone marrow examination on 14 day of chemotherapy is recommended to predict CR. Read More

View Article and Full-Text PDF

Editorial: Bone and Cartilage Diseases-The Role and Potential of Natural Products.

Front Pharmacol 2022 26;13:938303. Epub 2022 May 26.

Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, United States.

View Article and Full-Text PDF

Rare Case of High Grade Neuroendocrine Carcinoma Found on Bone Marrow Biopsy: A Case Report.

J Community Hosp Intern Med Perspect 2022 31;12(1):83-88. Epub 2022 Jan 31.

New York Cancer and Blood Specialists, Patchogue, USA.

Background: Neuroendocrine neoplasms (NENs) comprise a wide-ranging group of abnormal neoplasms with atypical presentations, from primary localized disease to extensive metastasis, reaching the bone and brain. The NENs are divided into two major groups: neuroendocrine tumors (NETs), which are well-differentiated tumors of any grade, and neuroendocrine carcinomas (NECs), which are poorly differentiated, high-grade cancers with a high risk of morbidity and mortality. The challenge of diagnosing NENs early, particularly prior to metastasis, highlights the importance of further studying these diseases. Read More

View Article and Full-Text PDF
January 2022

Application of Methods for a Morphological Analysis of the Femoral Diaphysis Based on Clinical CT Images to Prehistoric Human Bone: Comparison of Modern Japanese and Jomon Populations from Hegi Cave, Oita, Japan.

Biomed Res Int 2022 7;2022:2069063. Epub 2022 Jun 7.

Department of Macroscopic Anatomy, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan.

A morphological analysis of ancient human bones is essential for understanding life history, medical history, and genetic characteristics. In addition to external measurements, a three-dimensional structural analysis using CT will provide more detailed information. The present study examined adult male human skeletons excavated from Hegi cave, Nakatsu city, Oita Prefecture. Read More

View Article and Full-Text PDF

Murine typhus complicated by sHLH mimicking adult-onset Still's disease.

Rev Med Interne 2022 Jun 10. Epub 2022 Jun 10.

Department of Internal Medicine, University Hospital Lyon Croix-Rousse, Claude-Bernard University - Lyon 1, Lyon, France; University Claude-Bernard Lyon 1, Research on Healthcare Performance (RESHAPE), INSERM U1290, Lyon, France.

Introduction: Adult-onset Still's disease (AOSD) is a rare multisystemic disorder and a diagnostic challenge for physicians because of the wide range of differential diagnoses. Common features of AOSD and secondary hemophagocytic lymphohistiocytosis (sHLH) could favour diagnostic uncertainty, in particular in case of infection-related sHLH.

Observation: A 61-year-old man was admitted to our internal medicine department for suspected AOSD. Read More

View Article and Full-Text PDF

Comparison of Relative Value Units and 30-Day Outcomes Between Primary and Revision Pediatric Spinal Deformity Surgery.

Clin Spine Surg 2022 Jun 7. Epub 2022 Jun 7.

Northwell Health Long Island Jewish Medical Center, Queens, NY.

Study Design: Retrospective cohort study.

Objective: The aim of this study was to compare the relative value units (RVUs) and 30-day outcomes between primary and revision pediatric spinal deformity (PSD) surgery.

Summary Of Background Data: PSD surgery is frequently complicated by the need for reoperation. Read More

View Article and Full-Text PDF

Nanoclay-reinforced HA/alginate scaffolds as cell carriers and SDF-1 delivery-platforms for bone tissue engineering.

Int J Pharm 2022 Jun 9;623:121895. Epub 2022 Jun 9.

NanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain; Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN). Vitoria-Gasteiz, Spain. Electronic address:

Bone tissue engineering has come on the scene to overcome the difficulties of the current treatment strategies. By combining biomaterials, active agents and growth factors, cells and nanomaterials, tissue engineering makes it possible to create new structures that enhance bone regeneration. Herein, hyaluronic acid and alginate were used to create biologically active hydrogels, and montmorillonite nanoclay was used to reinforce and stabilize them. Read More

View Article and Full-Text PDF

Global DNA Methylation Profiling Reveals Differentially Methylated CpGs between Salivary Gland Pleomorphic Adenomas with Distinct Clinical Course.

Int J Mol Sci 2022 May 25;23(11). Epub 2022 May 25.

Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 Poznan, Poland.

Pleomorphic adenomas (PAs) are the most frequently diagnosed benign salivary gland tumors. Although the majority of PAs are characterized by slow growth, some develop very fast and are more prone to recur. The reason for such differences remains unidentified. Read More

View Article and Full-Text PDF

Morphological and structural differences between the hemipenes and hemiclitores of golden lancehead snakes, Bothrops insularis (Amaral, 1922), revealed by radiography.

Anat Histol Embryol 2022 Jun 8. Epub 2022 Jun 8.

Programa de Pós-graduação em Anatomia dos Animais Domésticos e Silvestres, Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brazil.

The golden lancehead (Bothrops insularis) is a critically endangered and island endemic snake. A remarkable characteristic of golden lanceheads is the high frequency of females showing hemiclitores. Here, we use radiography to identify morphological and structural differences between the hemipenes and hemiclitores in captive individuals. Read More

View Article and Full-Text PDF

Foraminal Access Strategies in Patients with Lumbar Posterolateral Fusions in Transforaminal Endoscopic Spine Surgery: Case Series and Technical Note.

Pain Physician 2022 05;25(3):E449-E455

Department of Neurosurgery, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI.

Background: The treatment of post-laminectomy lumbar radiculopathy in the setting of a large posterolateral fusion mass presents an anatomic challenge to the spine interventionalist.

Objective: To describe outcomes of awake, transforaminal endoscopic surgical treatment for patients presenting with lumbar radiculopathy after instrumented posterolateral lumbar fusions.

Study Design: Retrospective chart review. Read More

View Article and Full-Text PDF

Yaws in the Philippines: A clinico-seroprevalence study of selected communities in Mindanao.

PLoS Negl Trop Dis 2022 06 1;16(6):e0010447. Epub 2022 Jun 1.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Yaws is a chronic, highly contagious skin and bone infection affecting children living in impoverished, remote communities. It is caused by Treponema pallidum subsp. pertenue. Read More

View Article and Full-Text PDF

Minimal Clinically Important Changes in HOOS-12 and KOOS-12 Scores Following Joint Replacement.

J Bone Joint Surg Am 2022 06 22;104(11):980-987. Epub 2022 Feb 22.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Background: For patient-reported outcome measures (PROMs) to provide meaningful information to support clinical care, we need to understand the magnitude of change that matters to patients. The aim of this study was to estimate minimal clinically important changes (MCICs) for the 12-item Hip disability and Osteoarthritis Outcome Score (HOOS-12) and Knee injury and Osteoarthritis Outcome Score (KOOS-12) among people undergoing joint replacement for osteoarthritis.

Methods: Individual-level data from the Australian Orthopaedic Association National Joint Replacement Registry's pilot PROMs program were used for this analysis. Read More

View Article and Full-Text PDF

The lifetime revision risk of unicompartmental knee arthroplasty.

Bone Joint J 2022 Jun;104-B(6):672-679

Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago Christchurch, Christchurch, New Zealand.

Aims: Unicompartmental knee arthroplasty (UKA) has a higher risk of revision than total knee arthroplasty (TKA), particularly for younger patients. The outcome of knee arthroplasty is typically defined as implant survival or revision incidence after a defined number of years. This can be difficult for patients to conceptualize. Read More

View Article and Full-Text PDF

New Antibacterial Chloro-Containing Polyketides from the Alga-Derived Fungus KMM 4696.

J Fungi (Basel) 2022 Apr 27;8(5). Epub 2022 Apr 27.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-Letiya Vladivostoka, 159, 690022 Vladivostok, Russia.

Six new polyketides acrucipentyns A-F (-) were isolated from the alga-derived fungus KMM 4696. Their structures were established based on spectroscopic methods. The absolute configurations of acrucipentyn A was assigned by the modified Mosher's method and ROESY data analysis. Read More

View Article and Full-Text PDF

The Comparative Effectiveness of Ceftolozane/Tazobactam versus Aminoglycoside- or Polymyxin-Based Regimens in Multi-Drug-Resistant Infections.

Antibiotics (Basel) 2022 May 6;11(5). Epub 2022 May 6.

Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI 02908, USA.

infections are challenging to treat due to multi-drug resistance (MDR) and the complexity of the patients affected by these serious infections. As new antibiotic therapies come on the market, limited data exist about the effectiveness of such treatments in clinical practice. In this comparative effectiveness study of ceftolozane/tazobactam versus aminoglycoside- or polymyxin-based therapies among hospitalized patients with positive MDR cultures, we identified 57 patients treated with ceftolozane/tazobactam compared with 155 patients treated with aminoglycoside- or polymyxin-based regimens. Read More

View Article and Full-Text PDF

Cellular Prion Protein Expression in the Brain Tissue from -Infected Striped Dolphins ().

Animals (Basel) 2022 May 19;12(10). Epub 2022 May 19.

Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.

, a zoonotic pathogen of major concern to cetacean health and conservation, is responsible for severe meningo-encephalitic/myelitic lesions in striped dolphins (), often leading to their stranding and death. This study investigated, for the first time, the cellular prion protein (PrP) expression in the brain tissue from -infected, neurobrucellosis-affected striped dolphins. Seven -infected, neurobrucellosis-affected striped dolphins, found stranded along the Italian coastline (6) and in the Canary Islands (1), were investigated, along with five -uninfected striped dolphins from the coast of Italy, carrying no brain lesions, which served as negative controls. Read More

View Article and Full-Text PDF

Improving the Reliability of Literature Reviews: Detection of Retracted Articles through Academic Search Engines.

Eur J Investig Health Psychol Educ 2022 May 4;12(5):458-464. Epub 2022 May 4.

Metabolic Bone Diseases Research Group, Nursing Department, Nursing and Occupational Therapy College, University of Extremadura, 10003 Caceres, Spain.

Nowadays, a multitude of scientific publications on health science are being developed that require correct bibliographic search in order to avoid the use and inclusion of retracted literature in them. The use of these articles could directly affect the consistency of the scientific studies and could affect clinical practice. The aim of the present study was to evaluate the capacity of the main scientific literature search engines, both general (Gooogle Scholar) and scientific (PubMed, EMBASE, SCOPUS, and Web of Science), used in health sciences in order to check their ability to detect and warn users of retracted articles in the searches carried out. Read More

View Article and Full-Text PDF

Rothmund-Thomson syndrome investigated by two nationwide surveys in Japan.

Pediatr Int 2022 Jan;64(1):e15120

Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.

Background: Rothmund-Thomson syndrome (RTS) is an autosomal recessive genetic disorder characterized by poikiloderma of the face, small stature, sparse scalp hair, juvenile cataract, radial aplasia, and predisposition to cancers. Due to the rarity of RTS, the situation of patients with RTS in Japan has not been elucidated.

Methods: In 2010 and 2020, following the results of a primary questionnaire survey, a secondary questionnaire survey on RTS was conducted nationwide to investigate the number of RTS cases and their associated skin lesions, bone lesions, other clinical features, and quality of life in Japan. Read More

View Article and Full-Text PDF
January 2022

Full Endoscopic Surgery for Thoracic Pathology: Next Step after Mastering Lumbar and Cervical Endoscopic Spine Surgery?

Biomed Res Int 2022 16;2022:8345736. Epub 2022 May 16.

Department of Neurosurgery, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA.

Thoracic disc herniation and stenosis are relatively rare, and various symptoms make them difficult to diagnose. Due to the complexity of neural and vascular structure, surgical treatment of thoracic pathology is challenging. Endoscopic spine surgery is an emerging minimally invasive surgical option. Read More

View Article and Full-Text PDF

Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population.

BMJ 2022 05 25;377:e066222. Epub 2022 May 25.

University of Occupational and Environmental Health, Kitakyushu, Japan.

Objective: To assess whether eldecalcitol, an active vitamin D analogue, can reduce the development of type 2 diabetes among adults with impaired glucose tolerance.

Design: Double blinded, multicentre, randomised, placebo controlled trial.

Setting: Three hospitals in Japan, between June 2013 and August 2019. Read More

View Article and Full-Text PDF

Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy.

N Engl J Med 2022 05;386(21):1998-2010

From the Department of Pathology, Brigham and Women's Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana-Farber Cancer Institute (R.P.) - all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science, National Yang Ming Chiao Tung University (Y.-C.L., J.-H.L.) - both in Taipei, Taiwan; the Cancer Science Institute of Singapore, Singapore (J.K., Y.V.L., H.Y., M.A.B., D.G.T.); the Department of Biomedicine and Prevention, University of Rome Tor Vergata (E.F., G.F., L.V., C. Gurnari, M.T.V.), and UniCamillus-Saint Camillus International University of Health Sciences (E.F.), Rome, and Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna (M.Y.F., L. Cocco), and IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli" (C.F.), Bologna - all in Italy; the National Clinical Research Center for Blood Diseases and State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (Z.X., Jinqin Liu, H.H.); and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T., J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U., J.E.P.), Faculty of Medicine, University of New South Wales, Sydney, and the Department of Hematology, Prince of Wales Hospital, Randwick, NSW (J.E.P.) - both in Australia.

Background: Although hypomethylating agents are currently used to treat patients with cancer, whether they can also reactivate and up-regulate oncogenes is not well elucidated.

Methods: We examined the effect of hypomethylating agents on , a known oncogene that plays an important role in myelodysplastic syndrome and other cancers. Paired bone marrow samples that were obtained from two cohorts of patients with myelodysplastic syndrome before and after treatment with a hypomethylating agent were used to explore the relationships among changes in expression, treatment response, and clinical outcome. Read More

View Article and Full-Text PDF

When to add anti-angiogenesis drugs to EGFR-mutated metastatic non-small cell lung cancer patients: a real-world study from Taiwan.

BMC Cancer 2022 May 23;22(1):571. Epub 2022 May 23.

Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Road, North District, Taichung City, 40402, Taiwan.

Background: The addition of anti-angiogenesis drugs to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) or chemotherapy in patients with EGFR-mutant non-small cell lung cancer (NSCLC) can improve disease control. We conducted a study to evaluate the efficacy of combination therapeutic strategies and identify patients who could benefit from combination therapy.

Methods: This study enrolled patients with stage IV EGFR-mutant NSCLC treated with first-line EGFR-TKIs between January 2014 and December 2020. Read More

View Article and Full-Text PDF

Evidence of Linear Bone Flap Resorption in Patients Undergoing Autologous Cranioplasty Following Decompressive Craniectomy: A 3D Slicer Segmented Analysis of Serial Computed Tomography Images.

World Neurosurg 2022 May 18. Epub 2022 May 18.

Division of Plastic Surgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Objective: Autologous cranioplasty (CP) following decompressive craniectomy (DC) carries a risk of bone flap resorption (BFR). The current literature offers limited information regarding the natural progression of BFR and the rate at which it occurs. We aim to characterize the progression of BFR over time and elucidate risk factors for accelerated BFR. Read More

View Article and Full-Text PDF

Cervical spine ligamentum flavum gaps: MR characterisation and implications for interlaminar epidural injection therapy.

Reg Anesth Pain Med 2022 Aug 17;47(8):459-463. Epub 2022 May 17.

Department of Radiology, Hospital for Special Surgery, New York, New York, USA.

Background: Cervical epidural steroid injections are commonly performed to manage pain from cervical spine disease. Cadaveric studies have demonstrated incomplete ligamentum flavum fusion in the central interlaminar region with resultant midline gaps. We performed an MR-based characterization of cervical ligamentum flavum midline gaps to improve understanding of their prevalence and guide interventionalists in procedural planning. Read More

View Article and Full-Text PDF

Adolescent perspectives on participating in a feasibility trial investigating shoe inserts for patellofemoral pain.

J Foot Ankle Res 2022 May 16;15(1):37. Epub 2022 May 16.

School of Health and Rehabilitation Sciences: Physiotherapy, The University of Queensland, Brisbane, Australia.

Background: Patellofemoral pain (PFP) affects one-quarter of adolescents, yet there are few evidence-informed recommendations to treat PFP in this population. HAPPi Kneecaps! is a randomised, controlled, participant- and assessor-blind, parallel-group feasibility trial of shoe inserts for adolescents with PFP. The aim of this qualitative study was to explore adolescents' perspectives of participating in HAPPi Kneecaps!. Read More

View Article and Full-Text PDF