12,674 results match your criteria Bone Island


Increasing rates of surgical treatment for paediatric tibial shaft fractures: a national database study from between 2000 and 2012.

J Child Orthop 2019 Apr;13(2):213-219

Department of Orthopaedics Division of Pediatric Orthopaedic Surgery, Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Purpose: Tibia fractures are the third most common long bone fracture in children. Because of the remodelling potential of the tibial diaphysis, nonoperative treatment has historically been advocated for most tibial shaft fractures in children. The purpose of this study was to estimate the rate of surgical treatment of tibial shaft fractures over time and identify demographic factors associated with surgical treatment, utilizing a large, publicly available, national database. Read More

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http://dx.doi.org/10.1302/1863-2548.13.180163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442513PMC

Academic Metrics Do Not Explain the Underrepresentation of Women in Orthopaedic Training Programs.

J Bone Joint Surg Am 2019 Apr;101(8):e32

Department of Orthopedic Surgery and Biomedical Engineering, Columbia University, New York, NY.

Background: Among medical specialties, orthopaedic surgery persistently has one of the lowest representations of women in residency programs. This study examined whether differences exist in the academic metrics of the orthopaedic residency applicants and enrolled candidates by sex, which may be contributing to the persistent underrepresentation of women. Differences in enrollment rate in orthopaedic residency programs also were analyzed. Read More

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http://dx.doi.org/10.2106/JBJS.17.01372DOI Listing

Assessment of a Geriatric Hip Fracture Program: Analysis of Harmful Adverse Events Using the Global Trigger Tool.

J Bone Joint Surg Am 2019 Apr;101(8):704-709

Department of Orthopedics, Brown University, Providence, Rhode Island.

Background: The purpose of this study was to assess the impact of adding a geriatric comanagement program to the care of geriatric patients with a hip fracture at our hospital. The Institute for Healthcare Improvement (IHI) Global Trigger Tool (GTT) was used to follow the frequency and severity of adverse events occurring in hospitalized patients and to examine the effectiveness of a comanagement program (the Geriatric Hip Fracture Program [GHFP]).

Methods: Data were collected for patients treated for a hip fracture from 2010 to 2014, which was 1 year prior to (October 2010 to September 2011) and 2 years after the implementation of the GHFP, and were grouped into 3-month intervals for analysis. Read More

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http://dx.doi.org/10.2106/JBJS.18.00376DOI Listing
April 2019
1 Read

Islands of bone within bone.

Postgrad Med J 2019 Apr 16. Epub 2019 Apr 16.

Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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http://dx.doi.org/10.1136/postgradmedj-2019-136414DOI Listing

DNMT and HDAC inhibitors modulate MMP-9-dependent H3 N-terminal tail proteolysis and osteoclastogenesis.

Epigenetics Chromatin 2019 Apr 16;12(1):25. Epub 2019 Apr 16.

Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.

Background: MMP-9-dependent proteolysis of histone H3 N-terminal tail (H3NT) is an important mechanism for activation of gene expression during osteoclast differentiation. Like other enzymes targeting their substrates within chromatin structure, MMP-9 enzymatic activity toward H3NT is tightly controlled by histone modifications such as H3K18 acetylation (H3K18ac) and H3K27 monomethylation (H3K27me1). Growing evidence indicates that DNA methylation is another epigenetic mechanism controlling osteoclastogenesis, but whether DNA methylation is also critical for regulating MMP-9-dependent H3NT proteolysis and gene expression remains unknown. Read More

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http://dx.doi.org/10.1186/s13072-019-0270-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466663PMC

Clinical features and treatment of 140 cases of Marjolin's ulcer at a major burn center in southwest China.

Exp Ther Med 2019 May 7;17(5):3403-3410. Epub 2019 Mar 7.

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P.R. China.

Marjolin's ulcer is a type of malignant tumor that occurs in scar tissue. The present study aimed to summarize and analyze the aetiology, clinical characteristics, treatment methods, metastasis and prognosis of this disease. A total of 140 cases of Marjolin's ulcer encountered at the Institute of Burn Research, Southwest Hospital (Chongqing, China) between January 2013 and December 2017 were retrospectively analyzed. Read More

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http://dx.doi.org/10.3892/etm.2019.7364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447797PMC
May 2019
1 Read

Spiral Layer-by-Layer Micro-Nanostructured Scaffolds for Bone Tissue Engineering.

ACS Biomater Sci Eng 2018 Jun 25;4(6):2181-2192. Epub 2018 Apr 25.

Department of Orthopaedic Surgery, University of Connecticut Health, 263 Farmington Avenue, Farmington, Connecticut 06030, United States.

This Article reports the fabrication and characterization of composite micro-nanostructured spiral scaffolds functionalized with nanofibers and hydroxyapatite (HA) for bone regeneration. The spiral poly(lactic acid--glycolic acid) (PLGA) porous microstructure was coated with sparsely spaced PLGA nanofibers and HA to enhance surface area and bioactivity. Polyelectrolyte-based HA coating in a layer-by-layer (LBL) fashion allowed 10-70 M Ca/mm incorporation. Read More

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http://pubs.acs.org/doi/10.1021/acsbiomaterials.8b00393
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http://dx.doi.org/10.1021/acsbiomaterials.8b00393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455961PMC
June 2018
2 Reads

A new species of Homo from the Late Pleistocene of the Philippines.

Nature 2019 Apr 10;568(7751):181-186. Epub 2019 Apr 10.

National Museum of the Philippines, Manila, The Philippines.

A hominin third metatarsal discovered in 2007 in Callao Cave (Northern Luzon, the Philippines) and dated to 67 thousand years ago provided the earliest direct evidence of a human presence in the Philippines. Analysis of this foot bone suggested that it belonged to the genus Homo, but to which species was unclear. Here we report the discovery of twelve additional hominin elements that represent at least three individuals that were found in the same stratigraphic layer of Callao Cave as the previously discovered metatarsal. Read More

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http://dx.doi.org/10.1038/s41586-019-1067-9DOI Listing

Injectable Scaffold for Bone Marrow Stem Cells and Bone Morphogenetic Protein-2 to Repair Cartilage.

Cartilage 2019 Apr 11:1947603519841682. Epub 2019 Apr 11.

1 Department of Chemical Engineering and Pharmaceutical Technology, Universidad de La Laguna, La Laguna, Spain.

Objective: The limits of the microfracture (MFX) treatment in terms of lesion size and long-term tissue functionality makes it necessary to investigate different alternatives to repair focal cartilage lesions. The present study aims at evaluating the efficacy of a minimally invasive approach against the conventional MFX to repair a chondral defect in rabbits. An injectable scaffold of BMP-2 pre-encapsulated in PLGA microspheres dispersed in a Pluronic F-127 solution is proposed as support of cells and controlled delivery system for the growth factor. Read More

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http://dx.doi.org/10.1177/1947603519841682DOI Listing

Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis.

FASEB J 2019 Apr 5:fj201801067RR. Epub 2019 Apr 5.

Department of Medicine, Rhode Island Hospital-The Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.

In this study, we examined the effect of MC1568, a selective class IIa histone deacetylase (HDAC) inhibitor, on the development and progression of renal fibrosis in a murine model of renal fibrosis induced by unilateral ureteral obstruction (UUO). All 4 class IIa HDAC isoforms, in particular HDAC4, were up-regulated in renal epithelial cells of the injured kidney. Administration of MC1568 immediately after UUO injury reduced expression of α-smooth muscle actin (α-SMA), fibronectin, and collagen 1. Read More

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http://dx.doi.org/10.1096/fj.201801067RRDOI Listing
April 2019
1 Read
5.043 Impact Factor

Malpractice Litigation Following Traumatic Fracture.

J Bone Joint Surg Am 2019 Apr;101(7):e27

Department of Orthopaedic Surgery, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Background: Poor clinical outcomes and adverse events following orthopaedic trauma are common, which may lead to litigation. To our knowledge, factors associated with litigation following fracture care have not previously been evaluated.

Methods: A retrospective review of fracture-related malpractice lawsuits from 1988 to 2015 was completed utilizing VerdictSearch (ALM Media Properties), a medicolegal database. Read More

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http://dx.doi.org/10.2106/JBJS.18.00853DOI Listing
April 2019
5 Reads

Prospective Evaluation of Glenoid Bone Loss After First-time and Recurrent Anterior Glenohumeral Instability Events.

Am J Sports Med 2019 Apr;47(5):1082-1089

Uniformed Services University of Health Sciences, Bethesda, Maryland, USA.

Background:: Determining the amount of glenoid bone loss in patients after anterior glenohumeral instability events is critical to guiding appropriate treatment. One of the challenges in treating the shoulder instability of young athletes is the absence of clear data showing the effect of each event.

Purpose:: To prospectively determine the amount of bone loss associated with a single instability event in the setting of first-time and recurrent instability. Read More

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http://dx.doi.org/10.1177/0363546519831286DOI Listing
April 2019
2 Reads

Notch Signaling in Nestin-Expressing Cells in the Bone Marrow Maintains Erythropoiesis via Macrophage Integrity.

Stem Cells 2019 Apr 1. Epub 2019 Apr 1.

Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Notch signaling plays pivotal roles in both hematopoietic stem/progenitor and their niche cells. Myeloproliferative phenotypes are induced by disruption of Notch signaling in nonhematopoietic bone marrow (BM) cells. Nestin-expressing cells in the BM reportedly represent a component of the hematopoietic stem cell niche. Read More

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http://dx.doi.org/10.1002/stem.3011DOI Listing
April 2019
3 Reads

[The Project to Extend Healthy Life Expectancy by Having Fun, in Collaboration with Kobe Women's University (KWU)].

Yakugaku Zasshi 2019 ;139(4):533-538

Itoyaku.

We have conducted health promotion workshops in Kobe City, beginning in June 2016, to promote the view of pharmacies as community health centers that provide not only medicine but also offer support for maintaining and enhancing a person's health. To this end, we collaborated with Kobe Women's University (KWU). Our health promotion workshops included: 1. Read More

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http://dx.doi.org/10.1248/yakushi.18-00172-5DOI Listing
April 2019
2 Reads

Impact of obesity on operative treatment and inpatient outcomes of paediatric limb fractures.

Bone Joint J 2019 Apr;101-B(4):491-496

Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Aims: The aim of this study was to utilize a national paediatric inpatient database to determine whether obesity influences the operative management and inpatient outcomes of paediatric limb fractures.

Patients And Methods: The Kids' Inpatient Database (KID) was used to evaluate children between birth and 17 years of age, from 1997 and 2012, who had undergone open and closed treatment of humeral, radial and ulna, femoral, tibial, and ankle fractures. Demographics, hospital charges, lengths of stay (LOS), and complications were analyzed. Read More

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http://dx.doi.org/10.1302/0301-620X.101B4.BJJ-2018-0740.R2DOI Listing
April 2019
3 Reads

Rotational acetabular osteotomy for symptomatic hip dysplasia in patients younger than 21 years of age: seven- to 30-year survival outcomes.

Bone Joint J 2019 04;101-B(4):390-395

Hiroshima University, Higashi-Hiroshima, Japan.

Aims: The aim of this study was to report the long-term results of rotational acetabular osteotomy (RAO) for symptomatic hip dysplasia in patients aged younger than 21 years at the time of surgery.

Patients And Methods: We evaluated 31 patients (37 hips) aged younger than 21 years at the time of surgery retrospectively. There were 29 female and two male patients. Read More

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http://dx.doi.org/10.1302/0301-620X.101B4.BJJ-2018-1200.R1DOI Listing
April 2019
4 Reads

Intense bone fluorescence reveals hidden patterns in pumpkin toadlets.

Sci Rep 2019 Mar 29;9(1):5388. Epub 2019 Mar 29.

IPANEMA, CNRS, ministère de la Culture; UVSQ, USR 3461, Université Paris-Saclay, F-91192, Gif-sur-Yvette, France.

The phenomenon of fluorescence can be used by animals to change effective colouration or patterning, potentially to serve functions including intra- and interspecific signalling. Initially believed to be restricted to marine animals, fluorescent colours are now being described in an increasing number of terrestrial species. Here, we describe unique, highly fluorescent patterns in two species of pumpkin toadlets (Brachycephalus ephippium and B. Read More

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http://www.nature.com/articles/s41598-019-41959-8
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http://dx.doi.org/10.1038/s41598-019-41959-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441030PMC
March 2019
6 Reads

Raman spectroscopy investigation shows that mineral maturity is greater in CD-1 than in C57BL/6 mice distal femurs after sexual maturity.

Connect Tissue Res 2019 Mar 28:1-11. Epub 2019 Mar 28.

a Department of Physical Therapy , City University of New York, College of Staten Island , New York , NY , USA.

Purpose/Aim of the study: mice are the most often used pre-clinical lab models for studying the pathologies of bone mineralization. However, recent evidence suggests that two of the most often used mice strains (C57BL/6J and CD-1) might show differences in the bone mineralization process. This study sought to investigate the main compositional properties of bone tissue between nonpathological C57BL/6J and CD-1 murine knee joints. Read More

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http://dx.doi.org/10.1080/03008207.2019.1601184DOI Listing

Prognosis for Recovery of Foot Drop after Transforaminal Endoscopic Decompression of Far Lateral Lumbar 5-Sacral 1 Herniated Disc: Case Series.

Pain Physician 2019 03;22(2):E97-E103

Department of Neurosurgery, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI.

Background: Foot drop that results from compression of the exiting L5 nerve as a result of far lateral disc herniation (FLDH) at L5-S1 poses a significant surgical challenge to the minimally-invasive spine surgeon given the narrow corridor for an extraforaminal approach because of the high iliac crest.

Objectives: Here we describe our experience with transforaminal endoscopic decompression for the treatment of foot drop secondary to FLDH at L5-S1.

Study Design: Retrospective case review. Read More

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March 2019
1 Read

Stem Cells & Extracellular Vesicles in Physiology & Disease.

Am J Physiol Cell Physiol 2019 Mar 27. Epub 2019 Mar 27.

Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medi- cal School of Brown University, Providence, RI, United States.

Many different subpopulations of subcellular extracellular vesicles (EVs) have been described. EVs are released from all cell types and have been shown to regulate normal physiological homeostasis, as well as pathological states by influencing cell proliferation, differentiation, organ homing, injury and recovery, as well as disease progression. In this review, we focus on the bi-directional actions of vesicles from normal and diseased cells on normal or leukemic target cells; and on the leukemic microenvironment as a whole. Read More

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http://dx.doi.org/10.1152/ajpcell.00017.2019DOI Listing
March 2019
1 Read

Phenotype and response to growth hormone therapy in siblings with B4GALT7 deficiency.

Bone 2019 Mar 23;124:14-21. Epub 2019 Mar 23.

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110, USA.

B4GALT7 encodes beta-1,4-galactosyltransferase which links glycosaminoglycans to proteoglycans in connective tissues. Rare, biallelic variants in B4GALT7 have been associated with spondylodysplastic Ehlers-Danlos and Larsen of Reunion Island syndromes. Thirty patients with B4GALT7-related disorders have been reported to date with phenotypic variability. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.029DOI Listing
March 2019
1 Read

Hypercalcemia and acute kidney injury induced by eldecalcitol in patients with osteoporosis: a case series of 32 patients at a single facility.

Ren Fail 2019 Nov;41(1):88-97

a Division of Kidney Center , Matsuyama Red Cross Hospital , Matsuyama , Japan.

Background: Eldecalcitol (ELD) is an active vitamin D analog that is widely used in Japan for the treatment of osteoporosis. The most common adverse drug reaction of ELD is hypercalcemia. However, few reports have focused on acute kidney injury (AKI) associated with ELD-induced hypercalcemia. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1578667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442105PMC
November 2019
1 Read

Examination and Management of a 4-Year-Old Following a Femoral Aneurysmal Bone Cyst: A Case Report.

Pediatr Phys Ther 2019 04;31(2):E1-E7

Department of Physical Therapy, Long Island University, Brooklyn, New York.

Purpose: The literature lacks recommendations for postoperative rehabilitation following removal of aneurysmal bone cysts (ABCs). This case report describes the rehabilitation with return to age-appropriate functional activities for a 4-year-old following surgical fixation of a femoral ABC, with emphasis on clinical decision-making in the absence of definitive treatment algorithms.

Summary Of Key Points: The child improved in range of motion, strength, balance, transfers, gait, stair negotiation, and percentile rank on the Test of Gross Motor Development 2. Read More

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http://dx.doi.org/10.1097/PEP.0000000000000603DOI Listing

Twenty-five years of experience with the submental flap in facial reconstruction: Evolution and technical refinements following 311 cases in Europe and Africa.

Plast Reconstr Surg 2019 Mar 12. Epub 2019 Mar 12.

Background: The submental flap is a pedicled island flap with excellent colour match for facial reconstruction. The flap can be raised with muscle, submandibular gland or bone and can be transposed to reach defects up to two thirds of the face. We report the primary author's experience of 25 years using the submental flap from its original description to most recent technical evolutions in both Europe and Africa. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005678DOI Listing

Baricitinib: The Second FDA-Approved JAK Inhibitor for the Treatment of Rheumatoid Arthritis.

Ann Pharmacother 2019 Mar 24:1060028019839650. Epub 2019 Mar 24.

2 Rhode Island Hospital, Providence, RI, USA.

Objective: To review the pharmacology, pharmacokinetics, safety, and efficacy of baricitinib, a recently approved selective Janus Kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA), and explore its potential role in therapy.

Data Sources: Articles were identified using a PubMed search from inception through January 2019 using the terms rheumatoid arthritis, Olumiant, baricitinib, and LY3009104, its molecular name.

Study Selection And Data Extraction: Articles relating to randomized clinical trials, pharmacology, pharmacokinetics, efficacy, and safety of baricitinib were evaluated. Read More

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http://dx.doi.org/10.1177/1060028019839650DOI Listing
March 2019
2 Reads

Bipartite patella separation and partial quadriceps tendon rupture in the setting of trauma.

Radiol Case Rep 2019 Apr 22;14(4):526-529. Epub 2018 Oct 22.

Department of Radiology, Richmond University Medical Center, 355 Bard Ave. Staten Island, NY 11310, USA.

Normal development of the patella typically involves fusion of secondary ossification centers into a single bone during adolescence, with failure of fusion resulting in bipartite and tripartite patellae. In such variants, injury to incomplete ossification center fusion, though uncommon, has been reported to occur in the setting of traumatic quadriceps tendon rupture. The authors present a rare and complex case of traumatic bipartite fragment separation, patellar avulsion, and a complex partial quadriceps tendon tear confirmed surgically in a 36-year-old male. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183032
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http://dx.doi.org/10.1016/j.radcr.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412164PMC
April 2019
6 Reads

Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia.

Leukemia 2019 Mar 20. Epub 2019 Mar 20.

INSERM U1170, Gustave Roussy Cancer Center, Villejuif, France.

Islands of CD123 cells have been commonly described in the bone marrow of patients with chronic myelomonocytic leukemia (CMML). Using a multiparameter flow cytometry assay, we detected an excess of CD123 mononucleated cells that are lineage-negative, CD45, CD11c, CD33, HLA-DR, BDCA-2, BDCA-4 in the bone marrow of 32/159 (20%) patients. Conventional and electron microscopy, flow cytometry detection of cell surface markers, gene expression analyses, and the ability to synthesize interferon alpha in response to Toll-like receptor agonists identified these cells as bona fide plasmacytoid dendritic cells (pDCs). Read More

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http://dx.doi.org/10.1038/s41375-019-0447-3DOI Listing

Survival Trends in Infants Undergoing Allogeneic Hematopoietic Cell Transplant.

JAMA Pediatr 2019 Mar 18:e190081. Epub 2019 Mar 18.

Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Importance: Studies demonstrating improved survival after allogeneic hematopoietic cell transplant generally exclude infants.

Objective: To analyze overall survival trends and other outcomes among infants who undergo allogeneic hematopoietic cell transplant.

Design, Setting, And Participants: In this cohort study, we used time-trend analysis to evaluate 3 periods: 2000 through 2004, 2005 through 2009, and 2010 through 2014. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2019.0081DOI Listing
March 2019
2 Reads

The effects of high impact exercise intervention on bone mineral density, physical fitness, and quality of life in postmenopausal women with osteopenia: A retrospective cohort study.

Medicine (Baltimore) 2019 Mar;98(11):e14898

Department of Orthopaedic Surgery.

Osteoporosis and osteopenia prevailed in postmenopausal women and predisposed to osteoporotic fractures that increase mortality, morbidity, and the cost of social care. Here, we investigated the effect of 24 weeks of aerobic dancing on the bone miner density, physical fitness and health-related quality of life (HRQoL) in postmenopausal women with osteopenia. Total 80 participants (control [CON]: 40; exercise [EX]: 40) were included in the final analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426501PMC
March 2019
1 Read

Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration.

Kidney Int 2019 May 12;95(5):1064-1078. Epub 2019 Mar 12.

Maimonides Institute for Biomedical Research (IMIBIC), Cordoba, Spain; Nephrology Service, Reina Sofia University Hospital, Cordoba, Spain; University of Cordoba, Cordoba, Spain; Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, Madrid, Spain.

Calcimimetics decrease parathyroid hormone (PTH) secretion in patients with secondary hyperparathyroidism. The decrease in PTH should cause a reduction in bone turnover; however, the direct effect of calcimimetics on bone cells, which express the calcium-sensing receptor (CaSR), has not been defined. In this study, we evaluated the direct bone effects of CaSR activation by a calcimimetic (AMG 641) in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.015DOI Listing
May 2019
5 Reads

Tongue flap for keratinized soft tissue coverage around dental implants: a case report and discussion.

J Oral Implantol 2019 Mar 15. Epub 2019 Mar 15.

3 Long Island Jewish Medical Center Dental medicine Kings County Hospital Center. Currently Long Island Jewish Medical Center.

The tongue flap is a hardy flap that is routinely utilized by oral and maxillofacial surgeons to cover intraoral defects. It has not been described as a method for keratinized soft tissue coverage in conjunction with dental implant placement. In this article, we use the tongue flap in the closure of a chronic anterior maxillary dehiscence and to provide keratinized soft tissue coverage for anterior dental implants. Read More

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http://dx.doi.org/10.1563/aaid-joi-D-18-00140DOI Listing

Infantile myofibromatosis treated by mandibulectomy and staged reconstruction with submental flap and free fibula flap: a case report.

J Otolaryngol Head Neck Surg 2019 Mar 14;48(1):14. Epub 2019 Mar 14.

Département d'ophtalmologie et d'oto-rhino-laryngologie - chirurgie cervico-faciale, Faculté de Médecine, Université Laval, 1050, avenue de la Médecine, Québec, QC, G1V 0A6, Canada.

Background: Infantile myofibromatosis is the most common benign fibrous tumor in infants. Three different types have been reported in the literature. The most commonly affected areas are the head, the neck and the trunk. Read More

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http://dx.doi.org/10.1186/s40463-019-0333-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419343PMC

A novel approach for computing 3D mice distal femur properties using high-resolution micro-computed tomography scanning.

Micron 2019 Jun 1;121:1-7. Epub 2019 Mar 1.

Department of Physical Therapy, City University of New York - College of Staten Island, USA; New York Centre for Biomedical Engineering, City University of New York - City College of New York, USA; Nanosciences Initiative, City University of New York - Advance Science Research Center, New York, USA. Electronic address:

One of the most-scanned joints in preclinical animal models dealing with musculoskeletal pathologies is the mouse knee. While three-dimensional (3D) characterization of bone tissue porosity have previously been performed on cortical bone, it has not yet been comprehensively performed for the subchondral bone (SB) and the calcified cartilage (CC), which compose the subchondral mineralized zone (SMZ). Thus, it remains challenging to assess changes that occur in the SMZ of the mouse knee during pathologies such as osteoarthritis. Read More

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http://dx.doi.org/10.1016/j.micron.2019.02.011DOI Listing
June 2019
1 Read

Mesenchymal chondrosarcoma of maxilla in paediatric patient.

BMJ Case Rep 2019 Mar 9;12(3). Epub 2019 Mar 9.

Department of Otorhinolaryngology - Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, Kelantan, Malaysia.

Chondrosarcoma (CS) is a malignant tumour of long and flat bone characterised by the formation of cartilage. Mesenchymal chondrosarcoma (MCS) is a rare subtype of CS that is more aggressive and may lead to erroneous diagnosis in a limited biopsy. The diagnosis is mainly based on the histopathological appearance of biphasic pattern of undifferentiated small round cells separated by islands of well-differentiated hyaline cartilage. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22896
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http://dx.doi.org/10.1136/bcr-2018-228969DOI Listing
March 2019
3 Reads

Medical and Audiological Indications for Implantable Auditory Devices.

Otolaryngol Clin North Am 2019 Apr;52(2):195-210

Department of Otolaryngology, Long Island Jewish Medical Center, Hearing and Speech Center, Northwell Health, 430 Lakeville Road, New Hyde Park, NY 11042, USA.

Implantable auditory devices (IADs) are a viable hearing restoration option for patients with hearing loss. Conditions such as chronic otitis externa, congenital aural atresia, and chronic otitis media can be treated with a variety of implants. Progressive disease are also amenable to restoration with IADs, providing stabilized hearing. Read More

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http://dx.doi.org/10.1016/j.otc.2018.11.001DOI Listing
April 2019
3 Reads

Targeting T Cell Malignancies Using CD4CAR T-Cells and Implementing a Natural Safety Switch.

Stem Cell Rev 2019 Mar 2. Epub 2019 Mar 2.

Division of Blood and Bone Marrow Transplantation, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.

T cell malignancies are aggressive diseases with no standard treatment available, often resulting in poor patient outcomes. Lately, the recent FDA approval of a CD19 CAR T cell therapy for B cell acute lymphoblastic leukemia has earned nationwide attention, leading to the possibility that success of CD19 CAR therapy can be extended to T cell malignancies. However, the impact of T cell depletion due to a shared antigen pool remains an issue to be resolved. Read More

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http://link.springer.com/10.1007/s12015-019-09876-5
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http://dx.doi.org/10.1007/s12015-019-09876-5DOI Listing
March 2019
12 Reads

Association between chronic kidney disease and carotid intima-media thickness in relation to circulating CD34-positive cell count among community-dwelling elderly Japanese men.

Atherosclerosis 2019 Apr 11;283:85-91. Epub 2019 Feb 11.

Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of General Medicine, Nagasaki University Hospital, Nagasaki, Japan; Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Background And Aims: Endothelial injury is well-known as a process that can lead to chronic kidney disease (CKD) and atherosclerosis. Hematopoietic activity is known to be associated inversely with CKD and positively with atherosclerosis. Since bone-derived progenitor cells (CD34-positive cells) contribute to endothelial repair (including the progression of atherosclerosis), understanding the association between CKD and carotid intima-media thickness (CIMT), in relation to circulating CD34-positive cell count, may be an efficient means of clarifying the mechanisms underlying endothelial activity. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.004DOI Listing
April 2019
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INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma.

Future Oncol 2019 Feb 28. Epub 2019 Feb 28.

Department of Hematology, Clinica São Germano and Santa Casa Medical School, São Paulo, Brazil.

With the introduction of new drugs with different mechanisms of action, multiple myeloma (MM) patients' outcomes have improved. However, the efficacy seen in clinical trials is often not seen in real-world settings and data on the effectiveness of MM therapies are needed. INSIGHT MM is a prospective, global, non-interventional, observational study that is enrolling approximately 4200 patients with newly diagnosed or relapsed/refractory MM, making it the largest study of its kind to date. Read More

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https://www.futuremedicine.com/doi/10.2217/fon-2019-0013
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http://dx.doi.org/10.2217/fon-2019-0013DOI Listing
February 2019
4 Reads

Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis.

Exp Mol Med 2019 02 26;51(2):23. Epub 2019 Feb 26.

Department of Orthopedics, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.

The Wnt/β-catenin signaling pathway is associated with the pathogenesis of steroid-induced osteonecrosis. Our investigation studied whether aberrant CpG island hypermethylation of the FZD1 gene was present in patients with osteonecrosis of the femoral head (ONFH), which results in Wnt/β-catenin signaling inactivation and subsequent cell dysfunction. Bone marrow was collected from the proximal femurs of patients with steroid-associated ONFH (n = 21) and patients with new femoral neck fractures (n = 22), and then mesenchymal stem cells (MSCs) were isolated. Read More

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http://dx.doi.org/10.1038/s12276-019-0220-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391470PMC
February 2019
4 Reads

Waldenström Macroglobulinemia: Unusual Presentation With Cast Nephropathy/Light Chain Tubulopathy.

Clin Med Insights Case Rep 2019 15;12:1179547619828704. Epub 2019 Feb 15.

Department of Pathology, University of Iowa Health Care, Iowa City, IA, USA.

Cast Nephropathy/Light chain tubulopathy is usually present in patients with multiple myeloma and is very rare in patients with Waldenstrom Macroglobulinemia. There are very few case reports mentioned in the literature. We present an interesting case of Cast Nephropathy and light chain tubulopathy in an 81-year-old female patient with Waldenstrom Macroglobulinemia who required medical attention for worsening renal failure. Read More

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http://dx.doi.org/10.1177/1179547619828704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378479PMC
February 2019
1 Read

Mogamulizumab: a new tool for management of cutaneous T-cell lymphoma.

Onco Targets Ther 2019 7;12:1085-1094. Epub 2019 Feb 7.

Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA,

Cutaneous T-cell lymphoma (CTCL) poses unique treatment challenges, given its range of presentations and numerous systemic therapy options. These options often lack comparative evidence or are characterized by low response rates and short remission duration in relapsed/refractory disease. The approval of mogamulizumab, a humanized, glycoengineered IgG1κ monoclonal antibody targeting the chemokine receptor type 4 (CCR4) chemokine receptor, brings a novel tool into the spectrum of treatment options for advanced CTCL and adult T-cell leukemia/lymphoma (ATLL). Read More

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https://www.dovepress.com/mogamulizumab-a-new-tool-for-manag
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http://dx.doi.org/10.2147/OTT.S165615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369856PMC
February 2019
5 Reads
1.342 Impact Factor

Maximizing Sacral Chordoma Resection by Precise 3-Dimensional Tumor Modeling in the Operating Room Using Intraoperative Computed Tomography Registration with Preoperative Magnetic Resonance Imaging Fusion and Intraoperative Neuronavigation: A Case Series.

World Neurosurg 2019 Feb 18. Epub 2019 Feb 18.

Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, USA. Electronic address:

Introduction: The primary treatment for patients with sacral chordoma is en bloc surgical resection with negative margins, which has been shown to reduce local recurrence and tumor-related morbidity. Here we describe the use of intraoperative neuronavigation using preoperative spine magnetic resonance imaging fused to intraoperative computed tomography (CT) to create 3-dimensional tumor reconstructions in the operating room for intraoperative identification of bone and soft-tissue margins for maximal safe tumor resection.

Methods: A single-institution retrospective chart review was completed to encompass our experience of 6 consecutive patients who had sacral chordoma resections using our described navigation protocol. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.257DOI Listing
February 2019
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Adult Burkitt lymphoma- an Island between lymphomas and leukemias.

J Community Hosp Intern Med Perspect 2019 11;9(1):25-28. Epub 2019 Feb 11.

Department of Internal Medicine, Hackensack Meridian Health- Ocean Medical Centre, Brick, NJ, USA.

: Burkitt lymphoma is a rare, aggressive and rapidly fatal, B-cell non-Hodgkin's lymphoma. It has an incidence of 0.4/100,000 age-adjusted to the USA standard population. Read More

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https://www.tandfonline.com/doi/full/10.1080/20009666.2019.1
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http://dx.doi.org/10.1080/20009666.2019.1574545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374956PMC
February 2019
4 Reads

Specialized rainforest hunting by Homo sapiens ~45,000 years ago.

Nat Commun 2019 02 19;10(1):739. Epub 2019 Feb 19.

Department of Archaeology, Max Planck Institute for the Science of Human History, 07745, Jena, Germany.

Defining the distinctive capacities of Homo sapiens relative to other hominins is a major focus for human evolutionary studies. It has been argued that the procurement of small, difficult-to-catch, agile prey is a hallmark of complex behavior unique to our species; however, most research in this regard has been limited to the last 20,000 years in Europe and the Levant. Here, we present detailed faunal assemblage and taphonomic data from Fa-Hien Lena Cave in Sri Lanka that demonstrates specialized, sophisticated hunting of semi-arboreal and arboreal monkey and squirrel populations from ca. Read More

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http://dx.doi.org/10.1038/s41467-019-08623-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381157PMC
February 2019
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Fragmentation of the dorsal distal aspect of the talus on weanling survey and pre-sale radiographs of juvenile Thoroughbreds: prevalence and 2- and 3-year-olds racing performance.

Aust Vet J 2019 Mar 17;97(3):68-74. Epub 2019 Feb 17.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 250 Princes Hwy, Werribee, Victoria 3030, Australia.

Background: Fragmentation of the dorsal aspect of the distal talus (FDDT), at the dorsolateral articular margin of the proximal intertarsal joint (PITJ) on pre-sale radiographs of yearling Thoroughbreds has not been previously described and data to support decisions made by veterinarians to predict future racing potential of horses with these lesions are lacking.

Methods: In this retrospective case-control study we aimed to determine the prevalence of FDDT in juvenile Thoroughbreds and to report their race records. From a database of survey and repository radiographic examinations of 5709 horses, 36 with FDDT were identified. Read More

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http://dx.doi.org/10.1111/avj.12787DOI Listing

USP6 Gene Rearrangement by FISH Analysis in Cranial Fasciitis: A Report of Three Cases.

Head Neck Pathol 2019 Feb 13. Epub 2019 Feb 13.

Touro College of Dental Medicine at New York Medical College, 19 Skyline Drive Rm 427, Hawthorne, NY, 10532, USA.

Cranial fasciitis (CF) is an uncommon benign myofibroblastic proliferation involving the soft and hard tissues of the cranium. It typically occurs in the pediatric population with a male predilection (male-to-female ratio 1.5:1). Read More

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http://dx.doi.org/10.1007/s12105-019-01018-0DOI Listing
February 2019

Analysis of false start bone lesions produced by an electrical oscillating autopsy saw.

Int J Legal Med 2019 Feb 13. Epub 2019 Feb 13.

Institut Universitaire d'Anthropologie Médico-Légale, Faculté de Médecine, Université Côte d'Azur, 28, Avenue de Valombrose, 06107, Nice CEDEX 2, France.

Postmortem dismemberment results from the use of sharp or sharp blunt instruments. Saws produce specific bone lesions, and the observation of certain saw mark features allows for the recognition of certain characteristics of the saw and its teeth. At autopsy, sections of the skull and other parts of the skeleton are usually achieved using an electrical oscillating autopsy saw. Read More

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http://dx.doi.org/10.1007/s00414-019-02008-1DOI Listing
February 2019

Robotics-assisted versus conventional manual approaches for total hip arthroplasty: A systematic review and meta-analysis of comparative studies.

Int J Med Robot 2019 Jun 4;15(3):e1990. Epub 2019 Mar 4.

Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Taiyuan, China.

Background: Several studies have compared robotics-assisted (RA) and conventional manual (CM) approaches for total hip arthroplasty (THA), but their results are controversial.

Methods: A literature search was conducted for controlled clinical trials (CCTs) comparing the clinical efficacy of the RA and CM approaches for THA and published between August 1998 and August 2018. The obtained data were analyzed using the statistical software Review Manager 5. Read More

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http://dx.doi.org/10.1002/rcs.1990DOI Listing
June 2019
4 Reads

Myelofibrosis osteoclasts are clonal and functionally impaired.

Blood 2019 Feb 11. Epub 2019 Feb 11.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States;

Bone marrow (BM) sclerosis is commonly found in patients with late stage myelofibrosis (MF). Because osteoclasts (OC) and osteoblasts play a key role in bone remodeling, and MF monocytes, the OC precursors, are derived from the neoplastic clone, we wondered whether decreased OC numbers or impairment in their osteolytic function affects the development of osteosclerosis. Analysis of BM biopsies from 50 MF patients showed increased numbers of multinucleated tartrate-resistant acid phosphatase (TRAP)/cathepsin K-positive OC expressing phosphorylated Janus kinase (JAK)-2. Read More

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http://dx.doi.org/10.1182/blood-2018-10-878926DOI Listing
February 2019
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Pioglitazone Therapy in Patients With Stroke and Prediabetes: A Post Hoc Analysis of the IRIS Randomized Clinical Trial.

JAMA Neurol 2019 Feb 7. Epub 2019 Feb 7.

Department of Medicine, Yale School of Medicine, New Haven, Connecticut.

Importance: In the Insulin Resistance Intervention After Stroke (IRIS) randomized clinical trial, pioglitazone, an insulin-sensitizing agent, reduced the risk for recurrent stroke or myocardial infarction (MI) among patients with insulin resistance. However, insulin resistance is not commonly measured in clinical practice.

Objective: To analyze the effects of pioglitazone in patients with good adherence as well as intention-to-treat effects of pioglitazone in patients with prediabetes in the IRIS trial. Read More

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2019.0079DOI Listing
February 2019
31 Reads