14,318 results match your criteria Bone Island

Seabirds As Possible Reservoirs of Erysipelothrix rhusiopathiae on Islands Used for Conservation Translocations in New Zealand.

J Wildl Dis 2021 May 13. Epub 2021 May 13.

School of Veterinary Science, Massey University, Private Bag 11 222, Palmerston North 4442, New Zealand.

Erysipelothrix rhusiopathiae, the causative agent of the disease erysipelas, is a gram-positive bacillus, and an opportunistic pathogen in diverse species of animals. In New Zealand, E. rhusiopathiae has killed endangered birds on offshore islands, including Kākāpō (Strigops habroptilus), Takahē (Porphyrio hochstetteri), and Kiwi (Apteryx spp. Read More

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Case report of a rare giant bone island in a vertebral body combined with hemangioma.

J Int Med Res 2021 May;49(5):3000605211010699

Department of Orthopaedics, The First People's Hospital of Longquanyi District, Chengdu, Sichuan, China.

This case report describes a rare giant bone island combined with hemangioma diagnosed in a patient with osteolytic vertebral metastases. The bone island's greatest diameter was 3.15 cm, and bone islands of this size are rare in the literature. Read More

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Geology and taphonomy of a unique tyrannosaurid bonebed from the upper Campanian Kaiparowits Formation of southern Utah: implications for tyrannosaurid gregariousness.

PeerJ 2021 19;9:e11013. Epub 2021 Apr 19.

Department of Earth and Environmental Sciences, James Cook University of North Queensland, Townsville, QLD, Australia.

Tyrannosaurids are hypothesized to be gregarious, possibly parasocial carnivores engaging in cooperative hunting and extended parental care. A tyrannosaurid (cf. ) bonebed in the late Campanian age Kaiparowits Formation of southern Utah, nicknamed the Rainbows and Unicorns Quarry (RUQ), provides the first opportunity to investigate possible tyrannosaurid gregariousness in a taxon unique to southern Laramidia. Read More

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Long-term Outcomes after Gene Therapy for Adenosine Deaminase Severe Combined Immune Deficiency (ADA SCID).

Blood 2021 May 11. Epub 2021 May 11.

Duke University School of Medicine, Durham, North Carolina, United States.

Patients lacking functional adenosine deaminase activity suffer from severe combined immunodeficiency (ADA SCID), which can be treated with ADA enzyme replacement therapy (ERT), allogeneic hematopoietic stem cell transplantation (HSCT), or autologous HSCT with gene-corrected cells (gene therapy-GT). A cohort of 10 ADA SCID patients, aged 3 months to 15 years, underwent GT in a Phase II clinical trial between 2009 and 2012. Autologous bone marrow CD34+ cells were transduced ex vivo with the MND-ADA gamma-retroviral vector (gRV) and infused following busulfan reduced intensity conditioning. Read More

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Diffuse Paget's disease of the skull with intense uptake of Technetium-99m-labelled diphosphonate tracer in bone scintigraphy.

World Neurosurg 2021 Apr 30. Epub 2021 Apr 30.

Department of Radiology, SUNY Downstate Health Sciences University, Brooklyn, NY USA.

Imaging in patients with Paget's disease of bone is very important clinically in showing the presence of Pagetic abnormalities, assess disease progression, and identify adversely affected structures throughout disease course. Abnormalities and progression may be seen with X-ray, CT, MRI, and nuclear imaging. Herein, we report a case Paget's disease of bone showing diffuse characteristic pathology using technetium-99m-labelled diphosphonate tracer in bone scintigraphy (nuclear imaging). Read More

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Rethinking Greulich and Pyle: A Deep Learning Approach to Pediatric Bone Age Assessment Using Pediatric Trauma Hand Radiographs.

Radiol Artif Intell 2020 Jul 29;2(4):e190198. Epub 2020 Jul 29.

Department of Diagnostic Imaging, Rhode Island Hospital/Hasbro Children's Hospital, The Warren Alpert Medical School of Brown University, 593 Eddy St, Providence, RI 02903 (I.P., D.W.S., R.S.A.); Department of Diagnostic Imaging and Lifespan Biostatistics Core, Rhode Island Hospital, Providence, RI (G.L.B.); Department of Radiology, Columbia University Medical Center, New York, NY (S.M., C.R.); and Department of Emergency Medicine, University of Florida Shands Hospital, Gainesville, Fla (D.M.).

Purpose: To develop a deep learning approach to bone age assessment based on a training set of developmentally normal pediatric hand radiographs and to compare this approach with automated and manual bone age assessment methods based on Greulich and Pyle (GP).

Methods: In this retrospective study, a convolutional neural network (trauma hand radiograph-trained deep learning bone age assessment method [TDL-BAAM]) was trained on 15 129 frontal view pediatric trauma hand radiographs obtained between December 14, 2009, and May 31, 2017, from Children's Hospital of New York, to predict chronological age. A total of 214 trauma hand radiographs from Hasbro Children's Hospital were used as an independent test set. Read More

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Zygomatic Approach to Cavernous Sinus Chordoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Apr 30. Epub 2021 Apr 30.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Chordoma is not a benign disease. It grows invasively, has a high rate of local recurrence, metastasizes, and seeds in the surgical field.1 Thus, chordoma should be treated aggressively with radical resection that includes the soft tissue mass and the involved surrounding bone that contains islands of chordoma. Read More

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Epigenetic analysis of Paget's disease of bone identifies differentially methylated loci that predict disease status.

Elife 2021 Apr 30;10. Epub 2021 Apr 30.

College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.

Paget's Disease of Bone (PDB) is characterized by focal increases in disorganized bone remodeling. This study aims to characterize PDB associated changes in DNA methylation profiles in patients' blood. Meta-analysis of data from the discovery and cross-validation set, each comprising of 116 PDB cases and 130 controls, revealed significant differences in DNA methylation at 14 CpG sites, 4 CpG islands, and 6 gene-body regions. Read More

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Anastrozole Improves Final Adult Height in Severe Hypothyroidism With Rapid Pubertal Progression.

J Endocr Soc 2021 May 20;5(5):bvab025. Epub 2021 Feb 20.

Division of Pediatric Endocrinology, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.

Severe prolonged hypothyroidism due to Hashimoto thyroiditis may lead to rapid pubertal progression and compromised adult height after initiation of levothyroxine (LT4) therapy. There are no reports of aromatase inhibitor use to augment height in these patients. We describe a patient with severe hypothyroidism and growth failure who experienced rapid pubertal and bone age maturation on initiation of LT4 therapy. Read More

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Design and Mechanical Compatibility of Nylon Bionic Cancellous Bone Fabricated by Selective Laser Sintering.

Materials (Basel) 2021 Apr 14;14(8). Epub 2021 Apr 14.

School of Materials Science and Engineering, Henan University of Science and Technology, Luoyang 471023, China.

In order to avoid the stress shielding phenomenon in orthopedic bionic bone implantation, it is necessary to consider the design of mechanical compatible implants imitating the host bone. In this study, we developed a novel cancellous bone structure design method aimed at ensuring the mechanical compatibility between the bionic bone and human bone by means of computer-aided design (CAD) and finite element analysis technology (specifically, finite element modeling (FEM)). An orthogonal lattice model with volume porosity between 59% and 96% was developed by means of CAD. Read More

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Two-Staged Revision Total Ankle Arthroplasty Surgery with Primary Total Ankle Arthroplasty System: A Case Report.

JBJS Case Connect 2021 04 29;11(2). Epub 2021 Apr 29.

SWISS ORTHO CENTER, Schmerzklinik Basel, Swiss Medical Network, Basel, Switzerland.

Case: Case of a 2-staged revision surgical technique for the treatment of an aseptic total ankle arthroplasty (TAA) loosening: first surgery: removal of the loosened and painful TAA Scandinavian Total Ankle Replacement, with exclusion of infection, and reconstruction of the large bone defect (bone-defect downsizing surgery); proof of successful ankle bone reconstruction by CT-scan imaging; second surgery: implantation of a primary VANTAGE TAA (ankle reconstruction with new primary TAA).

Conclusion: The present case shows the management of a failed TAA with bone defect by performing a 2-step surgical approach: removal of loosened TAA with simultaneous bone stock restoration and then implantation of a new primary TAA. This concept is a possible alternative to a post-TAA ankle arthrodesis or to the use of a TAA revision system. Read More

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Histological Comparison between Biphasic Calcium Phosphate and Deproteinized Bovine Bone on Critical-Size Bone Defects.

Braz Dent J 2021 Jan-Feb;32(1):26-33

Department of Stomatology, UFPR - Universidade Federal do Paraná, Curitiba, PR, Brazil.

The limited options for bone repair have led to an extensive research of the field and the development of alloplastic and xenogeneic grafts. The purpose of this study was to evaluate bone repair with two bone substitutes: deproteinized bovine bone (DBB) and biphasic calcium phosphate ceramic (BCP) in critical-size defect. A total of 8-mm defects were made in the parietal bones of rabbits (n=12). Read More

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Prehospital shock index outperforms hypotension alone in predicting significant injury in trauma patients.

Trauma Surg Acute Care Open 2021 13;6(1):e000712. Epub 2021 Apr 13.

Department of Surgery, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA.

Background: The American College of Surgeons Resources for Optimal Care of the Injured Patient recommends using hypotension, defined as systolic blood pressure ≤90 mm Hg, as an indicator of a full team trauma activation. We hypothesized that an elevated shock index (SI) predicts significant traumatic injuries better than hypotension alone.

Methods: This is a retrospective cohort study analyzing full team trauma activations between February 2018 and January 2020, excluding transfers and those who had missing values for prehospital blood pressure or heart rate. Read More

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Dual-construct fixation is recommended in ipsilateral femoral neck fractures with infra-isthmus shaft fracture: A STROBE compliant study.

Medicine (Baltimore) 2021 Apr;100(17):e25708

Department of Orthopedic, Kaohsiung veteran general hospital, Kaohsiung, Taiwan.

Abstract: The aim of this study was to evaluate the risk factors related to osteosynthesis failure in patients with concomitant ipsilateral femoral neck and shaft fractures, including old age; smoking habit; comminuted fragments; infra-isthmus fracture; angular malreduction; unsatisfactory reduction (fracture gap >5 mm); and treatment with single construct.Patients over the age of 20 with concomitant ipsilateral femoral neck and shaft fractures diagnosed at a level one medical center between 2003 and 2019 were included. Treatment modalities included single construct with/without an antirotational screw for the neck and dual constructs. Read More

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Surgical repair of a meningoencephalocoele in a kākāpō ().

N Z Vet J 2021 Apr 28:1-8. Epub 2021 Apr 28.

The Nest Te Kōhanga, Wellington Zoo, Wellington, New Zealand.

Case History: A kākāpō () chick hatched on an off-shore island of New Zealand with a small white mass protruding through the cranial skin of the head. The chick's growth followed a normal pattern for kākāpō but at 3 weeks of age the cranium mass was non-reducible and fixed in place and the chick was removed from the island for diagnostic imaging and hand-rearing.

Clinical Findings And Treatment: A computed tomography (CT) examination revealed a full-thickness circular defect in the central cranium with suspected herniation of brain and dura. Read More

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Gastrocnemius pedicled muscle flap for knee and upper tibia soft tissue reconstruction. A useful tool for the orthopaedic surgeon.

Injury 2021 Apr 20. Epub 2021 Apr 20.

Department of Orthopaedic Surgery, University of Ioannina School of Medicine, Ioannina 45110, Greece. Electronic address:

Soft tissue defect coverage has always been a challenge for the orthopaedic surgeon. Over the last decades the surgery of flaps has completely changed the prognosis for large defects. The purpose of this study is to retrospectively review our experience with the gastrocnemius muscle as pedicled local flaps for reconstruction of knee and upper third of the tibia soft tissue defects. Read More

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Determinants of bone health in elderly Japanese men: study design and key findings of the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) cohort study.

Environ Health Prev Med 2021 Apr 23;26(1):51. Epub 2021 Apr 23.

Department of Public Health, Kindai University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

Background: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study was launched to investigate risk factors for osteoporotic fractures, interactions of osteoporosis with other non-communicable chronic diseases, and effects of fracture on QOL and mortality.

Methods: FORMEN baseline study participants (in 2007 and 2008) included 2012 community-dwelling men (aged 65-93 years) in Nara prefecture, Japan. Clinical follow-up surveys were conducted 5 and 10 years after the baseline survey, and 1539 and 906 men completed them, respectively. Read More

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The Prevalence and Associated Factors of Cancer Screening Uptake Among a National Population-Based Sample of Adults in Marshall Islands.

Cancer Control 2021 Jan-Dec;28:1073274821997497

Department of Psychology, 37702University of the Free State, Bloemfontein, South Africa.

Background: The study aimed to estimate the prevalence and associated factors of cancer screening among men and women in the general population in Marshall Islands.

Methods: The national cross-sectional sub-study population consisted of 2,813 persons aged 21-75 years (Median = 37.4 years) from the "2017/2018 Marshall Islands STEPS survey". Read More

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Did COVID-19 related delays in surgical management lead to patient morbidity in the orthopaedic oncological population?

Bone Jt Open 2021 Apr;2(4):236-242

Department of Orthopaedics, North Shore-Long Island Jewish Hospital, Northwell Health Medical Center, New Hyde Park, New York, USA.

Aims: The aim of this study was to assess orthopaedic oncologic patient morbidity resulting from COVID-19 related institutional delays and surgical shutdowns during the first wave of the pandemic in New York, USA.

Methods: A single-centre retrospective observational study was conducted of all orthopaedic oncologic patients undergoing surgical evaluation from March to June 2020. Patients were prioritized as level 0-IV, 0 being elective and IV being emergent. Read More

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Cost-effectiveness of sequential daily teriparatide/weekly alendronate compared with alendronate monotherapy for older osteoporotic women with prior vertebral fracture in Japan.

Arch Osteoporos 2021 04 17;16(1):72. Epub 2021 Apr 17.

Geriatric Research, Education and Clinical Center and HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

Using a Markov microsimulation model among hypothetical cohorts of community-dwelling older osteoporotic Japanese women with prior vertebral fracture over a lifetime horizon, we found that daily subcutaneous teriparatide for 2 years followed by weekly oral alendronate for 8 years was not cost-effective compared with alendronate monotherapy for 10 years.

Purpose: Teriparatide has proven efficacy in reducing osteoporotic fractures, but with substantial cost. We examined the cost-effectiveness of sequential teriparatide/alendronate (i. Read More

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Persistence with oral bisphosphonates and denosumab among older adults in primary care in Ireland.

Arch Osteoporos 2021 04 17;16(1):71. Epub 2021 Apr 17.

HRB Centre for Primary Care Research, Department of General Practice, Royal College of Surgeons in Ireland, Dublin, Ireland.

Gaps in pharmacological treatment for osteoporosis can reduce effectiveness. Among older adults, we found about half of new users of oral bisphosphonate and denosumab persisted with their treatment at 2 years, with few switching to alternative therapy. Persistence is suboptimal and warrants evaluation of interventions to improve this. Read More

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Effects of once-yearly zoledronic acid on bone density and incident vertebral fractures in nonmetastatic castration-sensitive prostate cancer patients with osteoporosis.

BMC Cancer 2021 Apr 17;21(1):422. Epub 2021 Apr 17.

Department of Palliative Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Androgen deprivation therapy (ADT) is the effective treating prostate cancer but is often accompanied by cancer treatment-induced bone loss (CTIBL), which impairs the patient's quality of life. In patients with nonmetastatic castration-sensitive prostate cancer (M0CSPC) who already have osteoporosis before starting ADT, appropriate bone-modifying agent intervention must be performed in parallel, as the patient has a high risk of future fracture. However, little is known about therapeutic interventions aimed at preventing the progression of CTIBL and new fractures. Read More

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B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers.

Nat Commun 2021 04 13;12(1):2208. Epub 2021 Apr 13.

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.

The B1 and B2 lineages of B cells contribute to protection from pathogens in distinct ways. The role of the DNA CpG methylome in specifying these two B-cell fates is still unclear. Here we profile the CpG modifications and transcriptomes of peritoneal B1a and follicular B2 cells, as well as their respective proB cell precursors in the fetal liver and adult bone marrow from wild-type and CD19-Cre Dnmt3a floxed mice lacking DNMT3A in the B lineage. Read More

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Analysis of the bone morphogenetic protein 6 gene promoter region in young beef cattle affected by enzootic bovine leukosis.

J Vet Med Sci 2021 Apr 9. Epub 2021 Apr 9.

Veterinary Medical Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo.

Enzootic bovine leukosis (EBL) is typically observed in cattle over 3 years old. However, some cases of EBL onset in young beef cattle have been reported in Japan. The mechanism for early EBL onset is unclear. Read More

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Effects of Myo-inositol Hexaphosphate (SNF472) on Bone Mineral Density in Patients Receiving Hemodialysis: An Analysis of the Randomized, Placebo-Controlled CaLIPSO Study.

Clin J Am Soc Nephrol 2021 Apr 7. Epub 2021 Apr 7.

Department of Medicine, Stanford University, Palo Alto, California.

Background And Objectives: In the CaLIPSO study, intravenous administration of SNF472 (300 or 600 mg) during hemodialysis significantly attenuated progression of coronary artery and aortic valve calcification. SNF472 selectively inhibits formation of hydroxyapatite, the final step in cardiovascular calcification. Because bone mineral is predominantly hydroxyapatite, we assessed changes in bone mineral density in CaLIPSO. Read More

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J Zoo Wildl Med 2021 Apr;52(1):268-275

University of Queensland, School of Veterinary Science, Gatton Campus, Gatton, Queensland 4343, Australia.

The impetus of this study was the imperative to establish blood biomarker values for clinically healthy mahogany gliders () in order to monitor the health status of eight captive individuals during their movement to a new facility. The study established ranges for 18 hematologic and 21 biochemical blood biomarkers for healthy individuals in a captive environment. The reported values are consistent with those published for other Australian glider and possum species. Read More

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Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study.

Radiol Imaging Cancer 2021 03 12;3(2):e200101. Epub 2021 Feb 12.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Box 8131, St Louis, MO 63110 (J.W.J.); Division of Interventional Radiology and Image-Guided Medicine, Emory University School of Medicine, Atlanta, Ga (J.D.P.); Department of Interventional Radiology, University Hospital of Strasbourg, Strasbourg, France (J.G., A.G.); Department of Radiology, Institut Bergonié, Bordeaux, France (X.B., J.P.); Department of Radiology, Mayo Clinic, Rochester, Minn (A.N.K., M.C.); Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, Calif (S.G., F.A.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.J.H.); Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI (J.I.); Departments of Radiology (F.P) and Interventional Radiology (C.M.), Centre Léon Bérard, Lyon, France; Department of Radiology, Ascension Providence Rochester Hospital, Rochester, Mich (P.J.L.); and Department of Interventional Radiology, Institut Gustave Roussy, Villejuif, France (T.d.B., F.D.).

Purpose: To assess the clinical effectiveness of cryoablation for palliation of painful bone metastases.

Materials And Methods: MOTION (Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases) (ClinicalTrials.gov NCT02511678) was a multicenter, prospective, single-arm study of adults with metastatic bone disease who were not candidates for or had not benefited from standard therapy, that took place from February 2016 to March 2018. Read More

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Surgical Management of Chiari Malformations: Preliminary Results of Surgery According to the Mechanisms of Ptosis of the Brain Stem and Cerebellum.

J Neurol Surg B Skull Base 2021 Apr 30;82(2):264-272. Epub 2019 Sep 30.

Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

 We classified Chiari malformation type I (CM-I) according to the mechanism of ptosis of the brain stem and cerebellum, based on a morphometric study of the posterior cranial fossa (PCF) and craniovertebral junction (CVJ). Surgery was performed to manage the mechanism of the hindbrain ptosis.  We calculated the volume of the PCF (VPCF) and the area surrounding the foramen magnum (VSFM) and measured the axial length of the enchondral parts of the occipital bone (occipital bone size) and the hindbrain. Read More

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Wiad Lek 2021 ;74(2):179-183


Objective: The aim: To clarify the sources and determine the chronological sequence of the germs of anatomical structures of the orbit at the early period of human ontogenesis.

Patients And Methods: Materials and methods: Using a complex of methods of morphological examination (morphometry, microscopy, three-dimensional computer reconstruction and statistical analysis) 30 series of consecutive histological sections of human embryos and prefetuses aged from 3 till 8 weeks od IUD (3.0-30. Read More

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Koshu GRoup Activity, Active Play and Exercise (GRAPE) Study: A Cluster Randomised Controlled Trial Protocol of a School-Based Intervention among Japanese Children.

Int J Environ Res Public Health 2021 03 24;18(7). Epub 2021 Mar 24.

Department of Health Sciences, Basic Science for Clinical Medicine, Division of Medicine, Graduate School Department of Interdisciplinary Research, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.

School-based programmes need to be effective, easy for all, easy to perform within a short duration, and inexpensive. However, no studies have reported whether voluntarily and very short-time active play programmes contribute to improved health outcomes. This study aims to describe the GRoup activity, Active Play and Exercise (GRAPE) cluster randomised controlled trial that examined whether active play interventions of very short durations contribute to increasing physical activity (PA) and bone mass among school-aged children. Read More

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