13,535 results match your criteria Bone Island


Mediterranean precipitation isoscape preserved in bone collagen δH.

Sci Rep 2020 May 22;10(1):8579. Epub 2020 May 22.

Department of Human Evolutionary Biology, Harvard University, 11 Divinity Avenue, Cambridge, MA, USA.

The prehistory of the Mediterranean region has long been a subject of considerable interest, particularly the links between human groups and regions of origin. We utilize the spatial variation in the δH and δO values of precipitation (isoscapes) to develop proxies for geographic locations of fauna and humans. Bone collagen hydrogen isotope ratios (δH) in cattle (and to a lesser extent, ovicaprids) across the Mediterranean reflect the isotopic differences observed in rainfall (but δO values do not). Read More

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http://dx.doi.org/10.1038/s41598-020-65407-0DOI Listing

The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development.

Bone Joint Res 2020 Feb 16;9(2):82-89. Epub 2020 May 16.

Department of Orthopedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Chondrocyte hypertrophy represents a crucial turning point during endochondral bone development. This process is tightly regulated by various factors, constituting a regulatory network that maintains normal bone development. Histone deacetylase 4 (HDAC4) is the most well-characterized member of the HDAC class IIa family and participates in different signalling networks during development in various tissues by promoting chromatin condensation and transcriptional repression. Read More

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http://dx.doi.org/10.1302/2046-3758.92.BJR-2019-0172.R1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229302PMC
February 2020

Outcomes of press-fit uncemented versus cemented hip arthroplasty in the oncologic patient.

J Orthop 2020 Nov-Dec;22:198-202. Epub 2020 May 4.

Department of Orthopaedic Surgery, North Shore-Long Island Jewish Medical Center, Northwell Health, 270-05 76th Avenue, New Hyde Park, NY, 11040, USA.

Background And Objectives: Cemented hip arthroplasty is considered the standard of care for treating both osteoporotic femoral neck fractures and pathologic disease of the proximal femur due to the ability to achieve strong fixation in poor quality bone. There is minimal literature evaluating uncemented arthroplasty for pathologic disease of the proximal femur. This objective of this study is to compare outcomes of patients undergoing cemented and uncemented arthroplasty of the proximal femur for an oncologic indication. Read More

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http://dx.doi.org/10.1016/j.jor.2020.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225596PMC

An incidental dense bone island: A review of potential medical and orthodontic implications of dense bone islands and case report.

J Orthod 2020 May 18:1465312520917975. Epub 2020 May 18.

Department of Orthodontics, Eastman Dental Hospital, University College London Hospitals NHS Foundation Trust, London, UK.

Dense bone islands (DBIs) are usually asymptomatic and do not require any treatment. This case report presents a DBI of an unusual presentation, which was an incidental finding on a radiograph of a 15-year-old orthodontic patient. The DBI lesion was 24 mm in size, occupying at least 50% of the alveolar process between the upper right canine and lateral incisor, extending up the lateral aspect of the anterior margin of the right nasal fossa. Read More

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http://dx.doi.org/10.1177/1465312520917975DOI Listing

Preoperative topical estrogen treatment versus placebo in 244 children with midshaft and posterior hypospadias.

J Clin Endocrinol Metab 2020 May 9. Epub 2020 May 9.

Centre de Référence Maladies Rares Développement Génital : du Fœtus à l'Adulte.

Purpose: Urethral fistula and dehiscence are common after hypospadias surgery. Preoperative androgens have been considered to reduce these complications although not evidence-based. Dermatologists have reported the benefits of topical Estrogens on skin healing. Read More

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http://dx.doi.org/10.1210/clinem/dgaa231DOI Listing

Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile.

BMJ Open 2020 May 7;10(5):e034838. Epub 2020 May 7.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Purpose: Environmental chemical exposures may adversely affect an array of adolescent health outcomes. Thus, we used the Health Outcomes and Measures of the Environment (HOME) study, a prospective cohort that recruited pregnant women and conducted longitudinal follow-up on children over the first 12 years of life, to determine if and when chemical exposures affect adolescent health.

Participants: We recruited 468 pregnant women (age range: 18-45 years) from the Cincinnati, Ohio region to participate in a cohort study between March 2003 and January 2006. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228515PMC

Epigenetic regulation of the ITGB4 gene in prostate cancer.

Exp Cell Res 2020 May 4:112055. Epub 2020 May 4.

Tasmanian School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia, 7000.

Background: Examination of epigenetic changes at the ITGB4 gene promoter reveals altered methylation at different stages of prostate tumour progression and these changes may, in part, explain the complex patterns of gene expression of this integrin observed. Transcriptional re-programming perturbs expression of cell adhesion molecules and underpins metastatic tumour cell behaviour. Decreasing expression of the cell adhesion molecule ITGB4, which encodes the beta subunit of the integrin, alpha6 beta4 (α6β4), has been correlated with increased tumour aggressiveness and metastasis in multiple tumour types including prostate cancer. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112055DOI Listing

Secondary osteon structural heterogeneity between the cranial and caudal cortices of the proximal humerus in white-tailed deer.

J Exp Biol 2020 May 4. Epub 2020 May 4.

Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY, USA

Cortical bone remodeling is an ongoing process triggered by microdamage, where osteoclasts resorb existing bone and osteoblasts deposit new bone in the form of secondary osteons (Haversian systems). Previous studies revealed regional variance in Haversian systems structure and possibly material, between opposite cortices of the same bone. As bone mechanical properties depend on tissue structure and material, it is predicted that bone mechanical properties will vary in accordance with structural and material regional heterogeneity. Read More

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http://dx.doi.org/10.1242/jeb.225482DOI Listing

Expanding the evolutionary explanations for sex differences in the human skeleton.

Evol Anthropol 2020 May 2. Epub 2020 May 2.

Department of Sociology and Anthropology, University of Rhode Island, South Kingstown, Rhode Island, USA.

While the anatomy and physiology of human reproduction differ between the sexes, the effects of hormones on skeletal growth do not. Human bone growth depends on estrogen. Greater estrogen produced by ovaries causes bones in female bodies to fuse before males' resulting in sex differences in adult height and mass. Read More

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http://dx.doi.org/10.1002/evan.21834DOI Listing

Communicating emerging risks of SGLT2 inhibitors-timeliness and transparency of medicine regulators.

BMJ 2020 04 29;369:m1107. Epub 2020 Apr 29.

Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1136/bmj.m1107DOI Listing

Timing of surgical fixation in traumatic spinal fractures.

Bone Joint J 2020 May;102-B(5):627-631

National Spinal Injuries Unit, Department of Trauma and Orthopaedic Surgery, Mater Misericordiae University Hospital, Dublin, Ireland, UCD School of Medicine & Medical Science, Dublin, Ireland.

Aims: The timing of surgical fixation in spinal fractures is a contentious topic. Existing literature suggests that early stabilization leads to reduced morbidity, improved neurological outcomes, and shorter hospital stay. However, the quality of evidence is low and equivocal with regard to the safety of early fixation in the severely injured patient. Read More

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http://dx.doi.org/10.1302/0301-620X.102B5.BJJ-2019-1716.R1DOI Listing

The cost of consent: why healthcare providers must be compliant with the Montgomery principles.

Bone Joint J 2020 May;102-B(5):550-555

Northern Medical Services, Newcastle upon Tyne, UK.

The cost of clinical negligence in the UK has continued to rise despite no increase in claims numbers from 2016 to 2019. In the US, medical malpractice claim rates have fallen each year since 2001 and the payout rate has stabilized. In Germany, malpractice claim rates for spinal surgery fell yearly from 2012 to 2017, despite the number of spinal operations increasing. Read More

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http://dx.doi.org/10.1302/0301-620X.102B5.BJJ-2019-1759DOI Listing

Reliability and Versatility of Reverse Sural Island Neurofasciocutaneous Leg Flaps.

Ann Plast Surg 2020 Apr 27. Epub 2020 Apr 27.

Clinic for Cardiovascular Surgery.

Background: Distally based sural neurofasciocutaneous (NFC) flaps are a commonly used method for foot and ankle reconstruction given that they are much simpler and, at the same time, still efficient alternative to perforator flaps and free style free flaps.

Objective: This study aims to evaluate the reliability and versatility of reverse sural island NFC flaps as a powerful and efficient method that can be used for repair of lower leg skin defects. This method does not require microsurgical facilities or extensive training. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002350DOI Listing

Point-of-Care Bone Age Evaluation: The Increasing Role of US in Resource-limited Populations.

Radiology 2020 Apr 28:201168. Epub 2020 Apr 28.

From the Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 (J.R.D.); Department of Diagnostic Imaging, Rhode Island Hospital-Hasbro Children's Hospital, Warren Alpert Medical School of Brown University, Providence, RI (R.S.A.).

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http://dx.doi.org/10.1148/radiol.2020201168DOI Listing

Patient-Reported Outcome Measures and Health-Related Quality-of-Life Scores of Patients Undergoing Anatomic Total Shoulder Arthroplasty.

J Bone Joint Surg Am 2020 Apr 28. Epub 2020 Apr 28.

Division of Shoulder and Elbow Surgery (E.S.P. and A.G.), Department of Orthopedic Surgery (S.S.J. and S.F.D.), Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Background: Health-related quality-of-life (HRQoL) scores are required for cost-effectiveness and health-care value analysis. We evaluated HRQoL scores and patient-reported outcome measures (PROMs) in patients with advanced glenohumeral osteoarthritis treated with anatomic total shoulder arthroplasty to establish values of HRQoL scores that can be used for cost-effectiveness and value analysis and to assess relationships between HRQoL scores and shoulder and upper-extremity PROMs.

Methods: We analyzed 143 patients (143 shoulders) with glenohumeral osteoarthritis treated with anatomic total shoulder arthroplasty; 92 patients had 1-year follow-up. Read More

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http://dx.doi.org/10.2106/JBJS.20.00402DOI Listing

Labyrinthine concussion: Historic otopathologic antecedents of a challenging diagnosis.

Laryngoscope Investig Otolaryngol 2020 Apr 16;5(2):267-277. Epub 2020 Mar 16.

Department of Otolaryngology Harvard Medical School Boston Massachusetts.

Objective: The term "labyrinthine concussion" has evolved to mean audiovestibular dysfunction in the absence of a temporal bone fracture (TBF). Despite a multitude of case descriptions of labyrinthine concussion, the precise pathophysiology remains poorly understood. Herein, we explore the historical otopathologic underpinnings of the diagnosis of labyrinthine concussion with a focus on the auditory pathway during the late 19th to the mid-20th centuries and conclude with a discussion of its contemporary relevance. Read More

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http://dx.doi.org/10.1002/lio2.360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178453PMC

The association between renal function and BMD response to bisphosphonate treatment: Real-world cohort study using linked national registers.

Bone 2020 Apr 22:115371. Epub 2020 Apr 22.

Dept. of Endocrinology, Odense University Hospital, DK-5000 Odense C, Denmark.

Background: Management of osteoporosis given reduced renal function is one of the largest challenges in the bone clinic.

Objectives: Identify the cut-off for renal function below which there would be no overall BMD benefit associated with bisphosphonate use. Track safety outcomes resulting in hospital encounters. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115371DOI Listing

A rostral neurovascular system in the mosasaur Taniwhasaurus antarcticus.

Naturwissenschaften 2020 Apr 24;107(3):19. Epub 2020 Apr 24.

Laboratorio de Anatomía Comparada y Evolución de los Vertebrados, Museo Argentino de Ciencias Naturales "Bernardino Rivadavia", Av. Ángel Gallardo 470, C1405DJR, Buenos Aires, Argentina.

Mosasaurs were a cosmopolitan group of marine squamate reptiles that lived during the Late Cretaceous period. Tylosaurinae mosasaurs were characterized for having an edentulous rostrum anterior to the premaxillary teeth. External morphology of the snout of the tylosaurine Taniwhasaurus antarcticus from the Upper Cretaceous beds at James Ross Island (Antarctic Peninsula) shows a complex anatomy with diverse large foramina and bone sculpture. Read More

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http://dx.doi.org/10.1007/s00114-020-01677-yDOI Listing

First fossil frog from Antarctica: implications for Eocene high latitude climate conditions and Gondwanan cosmopolitanism of Australobatrachia.

Sci Rep 2020 Apr 23;10(1):5051. Epub 2020 Apr 23.

JURASSICA Museum, Route de Fontenais 21, 2900, Porrentruy, Switzerland.

Cenozoic ectothermic continental tetrapods (amphibians and reptiles) have not been documented previously from Antarctica, in contrast to all other continents. Here we report a fossil ilium and an ornamented skull bone that can be attributed to the Recent, South American, anuran family Calyptocephalellidae or helmeted frogs, representing the first modern amphibian found in Antarctica. The two bone fragments were recovered in Eocene, approximately 40 million years old, sediments on Seymour Island, Antarctic Peninsula. Read More

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http://dx.doi.org/10.1038/s41598-020-61973-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181706PMC

lncRNA HOTAIRM1 promotes osteogenesis of hDFSCs by epigenetically regulating HOXA2 via DNMT1 in vitro.

J Cell Physiol 2020 Apr 23. Epub 2020 Apr 23.

Department of Orthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.

Dental follicle (DF) can develop into periodontal tissues including periodontal ligament, cementum, and alveolar bone. Possessing superior pluripotency and osteogenic capacity, dental follicle stem cells (DFSCs) have become a promising stem cell source for bone regeneration and periodontal engineering. However, the mechanisms underlying DFSCs-mediated osteogenesis remain elusive. Read More

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http://dx.doi.org/10.1002/jcp.29695DOI Listing

Osteocyte TGFβ1‑Smad2/3 is positively associated with bone turnover parameters in subchondral bone of advanced osteoarthritis.

Int J Mol Med 2020 Apr 14. Epub 2020 Apr 14.

Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.

Subchondral sclerosis is considered the main characteristic of advanced osteoarthritis, in which bone remodeling mediated by transforming growth factor β (TGFβ) signaling plays an indispensable role in the metabolism. Osteocytes have been identified as pivotal regulators of bone metabolism, due to their mechanosensing and endocrine function. Therefore, the aim of the present study was to investigate the association between osteocyte TGFβ signal and subchondral sclerosis. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4576DOI Listing

Improving immunogenicity and safety of flagellin as vaccine carrier by high-density display on virus-like particle surface.

Biomaterials 2020 Aug 12;249:120030. Epub 2020 Apr 12.

Biomedical & Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA. Electronic address:

Flagellin is a protein-based adjuvant that activates toll-like receptor (TLR) 5. Flagellin has been actively explored as vaccine adjuvants and carriers. Preclinical and clinical studies find flagellin-based vaccines have a risk to induce systemic adverse reactions potentially due to its overt activation of TLR5. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218678PMC

Transitioning from Gamma Rays to X Rays for Comparable Biomedical Research Irradiations: Energy Matters.

Radiat Res 2020 Apr 21. Epub 2020 Apr 21.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1667/RADE-20-00039.1DOI Listing

[Construction and optimization of an in vitro induction system for bone marrow-derived mesenchymal stem cell differentiation into hematopoietic cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2020 Feb;36(2):145-151

Department of Oncology, First Affiliated Hospital, Bengbu Medical College, Bengbu 233003, China. *Corresponding author, E-mail:

Objective To construct the hematopoietic microenvironment system simulating different hematopoietic sites during the embryonic stages for in vitro inducing the differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into hematopoietic cells, and to initially evaluate the efficiency of differentiation. Methods Stereomicroscopy and HE staining were used to observe the anatomical parts and morphology of yolk sac (YS), placenta (PL) and fetal liver (FL) of E11.5 mice. Read More

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February 2020

Mutations within the Activation Loop Domain of FLT3 in Two Pediatric Patients with Refractory Infant Acute Myeloid Leukemia.

Case Rep Oncol 2020 Jan-Apr;13(1):266-270. Epub 2020 Mar 24.

Division of Pediatric Hematology/Oncology, Brown University/Hasbro Children's Hospital, Providence, Rhode Island, USA.

Approximately 24% of all pediatric acute myeloid leukemia (AML) cases have mutations in the FMS-like tyrosine kinase 3 () receptor gene. FLT3-TKD point mutations are rare in pediatrics and often occur in younger patients and in combination with 11q23 abnormalities. There is a paucity of data related to their prognostic implications in children. Read More

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http://dx.doi.org/10.1159/000506194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154245PMC

Traumatic Brain Injury in Trauma Patients With Isolated Facial Fractures.

J Craniofac Surg 2020 Apr 7. Epub 2020 Apr 7.

Center for Surgery and Public Health.

Background: Diagnosis of traumatic brain injury (TBI), and specifically mild TBI (mTBI), is a diagnostic challenge which can delay diagnosis preventing early intervention and follow-up care. Facial fractures represent an objective surrogate marker for potential force transmission to the neural cavity. The authors' objective was to characterize the prevalence of TBI in trauma patients with isolated facial fractures stratified by injury severity. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006379DOI Listing

Large-scale identification of human bone remains via SNP microarray analysis with reference SNP database.

Forensic Sci Int Genet 2020 Apr 2;47:102293. Epub 2020 Apr 2.

Institute of Forensic and Anthropological Science, Seoul National University College of Medicine, Seoul, South Korea; Department of Forensic Medicine, Seoul National University College of Medicine, Seoul, South Korea. Electronic address:

Single nucleotide polymorphisms (SNPs) are valuable markers complementary to conventional forensic short tandem repeat (STR) markers in genetic typing, with potential advantages in challenging forensic casework. With the advent of high-throughput technologies, such as microarrays and massively parallel sequencing, the use of SNP typing has now expanded to large-scale forensic applications. Herein, a forensic case is presented to demonstrate the usefulness of SNP typing in identifying large-scale human bone remains with reference database construction. Read More

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http://dx.doi.org/10.1016/j.fsigen.2020.102293DOI Listing

Massive hemoperitoneum from hemorrhagic corpus luteum in a patient with acquired amegakaryocytic thrombocytopenic purpura.

Clin Case Rep 2020 Apr 7;8(4):719-721. Epub 2020 Mar 7.

Department of Obstetrics and Gynaecology Federal Medical Centre Yenagoa Nigeria.

Doctors should think of a spectrum of differential diagnoses in patients presenting with acute abdominal pain ranging from medical, surgical, and gynecological conditions. Proper laboratory and radiological tests including bone marrow study are advised. Read More

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http://dx.doi.org/10.1002/ccr3.2767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141734PMC

Mesenchymal Stem Cell Derived Extracellular Vesicles Ameliorate Kidney Injury in Aristolochic Acid Nephropathy.

Front Cell Dev Biol 2020 24;8:188. Epub 2020 Mar 24.

Department of Medical Sciences, University of Turin, Turin, Italy.

Limitations in the current therapeutic strategies for the prevention of progression of chronic kidney disease (CKD) to end stage renal disease has been a drawback to improving patient recovery. It is therefore imperative that a solution is found to alleviate this problem and improve the health and well-being of patients overall. Aristolochic acid (AA) induced nephropathy, a type of nephrotoxic CKD is characterised by cortical tubular injury, inflammation, leading to interstitial fibrosis. Read More

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http://dx.doi.org/10.3389/fcell.2020.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105599PMC

Multifunctional Properties of Quercitrin-Coated Porous Ti-6Al-4V Implants for Orthopaedic Applications Assessed In Vitro.

J Clin Med 2020 Mar 20;9(3). Epub 2020 Mar 20.

Group of Cell Therapy and Tissue Engineering, Department of Fundamental Biology and Health Sciences, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, 07122 Palma, Spain.

(1) One strategy to improve the outcome of orthopedic implants is to use porous implants with the addition of a coating with an antibacterial biomolecule. In this study, we aimed to produce and test the biocompatibility, the osteopromotive (both under normal conditions and under a bacterial challenge with lipopolysaccharide (LPS)) and antibacterial activities of a porous Ti-6Al-4V implant coated with the flavonoid quercitrin in vitro. (2) Porous Ti-6Al-4V implants were produced by 3D printing and further functionalized with quercitrin by wet chemistry. Read More

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http://dx.doi.org/10.3390/jcm9030855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141521PMC

Physiological changes in the size of the septal swell body correlate with changes in inferior turbinate size.

J Laryngol Otol 2020 Apr 3;134(4):323-327. Epub 2020 Apr 3.

Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, Sydney, Australia.

Objective: The nasal septal swell body is a normal anatomical structure located in the superior nasal septum anterior to the middle turbinate. However, the impact of the septal swell body in nasal breathing during normal function and disease remains unclear. This study aimed to establish that the septal swell body varies in size over time and correlates this with the natural variation of the inferior turbinates. Read More

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http://dx.doi.org/10.1017/S0022215120000675DOI Listing

Biomarkers in Usher syndrome: ultra-widefield fundus autofluorescence and optical coherence tomography findings and their correlation with visual acuity and electrophysiology findings.

Doc Ophthalmol 2020 Apr 2. Epub 2020 Apr 2.

The Discipline of Clinical Ophthalmology and Eye Health, Save Sight Institute, Sydney Eye Hospital, Faculty of Medicine and Health, The University of Sydney, 8 Macquarie Street, Sydney, NSW, 2001, Australia.

Purpose: To investigate the functional and structural biomarkers and their correlation with Usher syndrome (USH).

Methods: Medical records, imaging and electrophysiology test results of USH patients attending the Save Sight Institute between 2012 and 2017 were reviewed. Best corrected visual acuity (BCVA), ultra-widefield autofluorescence (UW-FAF), spectral-domain optical coherence tomography (SD-OCT), full-field electroretinogram and pattern electroretinogram (pERG) were performed. Read More

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http://dx.doi.org/10.1007/s10633-020-09765-0DOI Listing

[Literature research and discussion of Chinese medicinal properties of Morinda citrifolia].

Zhongguo Zhong Yao Za Zhi 2020 Mar;45(5):984-990

Beijing University of Chinese Medicine Beijing 100029, China.

Noni is a dry and mature fruit of Morinda citrifolia, which is widely distributed in the islands in the southern Pacific Ocean and the Indochina Peninsula in Asia. It is edible and has been used as a natural medicine for thousands of years. At present, Noni has been legally introduced into China, but there is no clear standard of traditional Chinese medicine properties and clinical application of traditional Chinese medicine, which greatly limits the application of compatibility with traditional Chinese medicine in China. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20191230.403DOI Listing

Risk Stratification of Precursors to Multiple Myeloma in 2020.

R I Med J (2013) 2020 Apr 1;103(3):46-47. Epub 2020 Apr 1.

Assistant Professor of Medicine, Alpert Medical School of Brown University, Division of Hematology-Oncology, Rhode Island Hospital/The Miriam Hospital, Providence, RI.

With advances in the treatment of plasma cell disorders, there have also been improvements in the risk stratification of these diseases. There are currently no screening recommendations for monoclonal gammopathy of unknown significance (MGUS); however, new studies are analyzing the role of screening for patients age 40-75 who are African American or have a family history of multiple myeloma (MM). Patients with smoldering multiple myeloma (SMM) have an increased risk of progression to MM when compared to MGUS. Read More

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Acute Myeloid Leukemia: A Review.

R I Med J (2013) 2020 Apr 1;103(3):38-40. Epub 2020 Apr 1.

Alpert Medical School of Brown University, Division of Hematology-Oncology, Rhode Island Hospital, Providence, RI.

Acute myeloid leukemia (AML) is a malignancy of the stem cell precursors of the myeloid lineage (red blood cells, platelets, and white blood cells other than B and T cells). Like other malignancies, it is due to genetic variations that lead to neoplastic changes and clonal proliferation. AML remains a rare malignancy, accounting for only 1. Read More

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An artificial intelligence algorithm that identifies middle turbinate pneumatisation (concha bullosa) on sinus computed tomography scans.

J Laryngol Otol 2020 Apr 1;134(4):328-331. Epub 2020 Apr 1.

Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, Australia.

Objective: Convolutional neural networks are a subclass of deep learning or artificial intelligence that are predominantly used for image analysis and classification. This proof-of-concept study attempts to train a convolutional neural network algorithm that can reliably determine if the middle turbinate is pneumatised (concha bullosa) on coronal sinus computed tomography images.

Method: Consecutive high-resolution computed tomography scans of the paranasal sinuses were retrospectively collected between January 2016 and December 2018 at a tertiary rhinology hospital in Australia. Read More

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http://dx.doi.org/10.1017/S0022215120000444DOI Listing

Plectranthias cruentus, a new species of anthiadine perchlet (Teleostei: Serranidae) from the Lord Howe Rise, Tasman Sea.

Zootaxa 2020 Mar 13;4750(4):zootaxa.4750.4.6. Epub 2020 Mar 13.

Macleay Collections, Chau Chak Wing Museum, and School of Life and Environmental Sciences, The University of Sydney, New South Wales 2006, Australia. Ichthyology, Australian Museum Research Institute, Australian Museum, 1 William Street, Sydney,New South Wales 2010, Australia..

Plectranthias cruentus new species is described from the holotype and two paratypes collected off Ball's Pyramid and a paratype from Lord Howe Island. It resembles P. pelicieri Randall Shimizu 1994 in live coloration and most morphological details, including absence of predorsal scales anterior to the supratemporal commissure, but differs in having the fifth or sixth (versus third) dorsal-fin spine longest, at least some pectoral-fin rays branched (versus all unbranched), and inconspicuous (versus distinct) serrations on the interopercle. Read More

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http://dx.doi.org/10.11646/zootaxa.4750.4.6DOI Listing

The barracudina genera Lestidium and Lestrolepis of Taiwan, with descriptions of two new species (Aulopiformes: Paralepididae).

Zootaxa 2019 Dec 4;4702(1):zootaxa.4702.1.16. Epub 2019 Dec 4.

National Museum of Marine Biology Aquarium, Checheng, Pingtung, Taiwan Institute of Marine Biology, National Dong Hwa University, Pingtung, Taiwan.

Two genera of barracudinas with luminescent duct in abdominal cavity, Lestrolepis and Lestidium, collected from around Taiwan are studied. Two species in each genus are recognized in Taiwan, including one new species in each genus. New diagnostic characters are used to distinguish these species. Read More

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http://dx.doi.org/10.11646/zootaxa.4702.1.16DOI Listing
December 2019

A new pearlfish, Onuxodon albometeori sp. nov. (Ophidiiformes: Carapidae), from Taiwan.

Authors:
Keita Koeda

Zootaxa 2019 Dec 4;4702(1):zootaxa.4702.1.4. Epub 2019 Dec 4.

National Museum of Marine Biology Aquarium, 2 Houwan Road, Checheng, Pingtung 94450, Taiwan Present address: Kuroshio Biological Research Foundation, 560 Nishidomari, Otsuki, Kochi 788-0333, Japan.

Onuxodon albometeori sp. nov. (Ophidiiformes: Carapidae) is described from a single specimen collected by commercial trawl off southwestern Taiwan. Read More

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http://dx.doi.org/10.11646/zootaxa.4702.1.4DOI Listing
December 2019

Implications of HLA diversity among regions for bone marrow donor searches in Japan.

HLA 2020 Mar 27. Epub 2020 Mar 27.

Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.

Japan is an island country, and the Japanese people have had minimal genetic exchange with other ethnolinguistic groups. Consequently, the population is highly uniform and has limited HLA diversity relative to people from other countries. However, Japan has three ethnolinguistic groups, and HLA distributions differ depending on geographic region. Read More

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http://dx.doi.org/10.1111/tan.13881DOI Listing

USE OF THE ESA RESISTANCE INDEX TO GUIDE DOSING FOR ANAEMIA MANAGEMENT.

J Ren Care 2020 Mar 27. Epub 2020 Mar 27.

University of Florida Shands Hospital, Gainesville, Florida, USA.

Background: Identifying erythropoiesis-stimulating agent (ESA) resistance is important for treating reversible causes, reaching target haemoglobin levels with minimal dosing, avoiding adverse effects and reducing costs. The resistance index (RI, dose/kg weight/g haemoglobin/dl) is reportedly superior to absolute or weight-based dosing.

Objectives: With the growing number of ESA classes and medications, our goal was to develop methodology to establish RI ranges in otherwise healthy haemodialysis patients as a structured approach to identify remediable causes of anaemia. Read More

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http://dx.doi.org/10.1111/jorc.12324DOI Listing

Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial.

Nutrients 2020 Mar 24;12(3). Epub 2020 Mar 24.

Bone Mineral Research, NYU Winthrop Hospital/NYU Langone Health, Mineola, NY 11501, USA.

Abdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment is associated with increased cardiovascular risk. Vitamin D deficiency and toxicity have been linked with vascular calcification. The objective of this study was to determine the effect of high-dose vitamin D on the progression of AAC. Read More

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http://dx.doi.org/10.3390/nu12030861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146156PMC

The Reliability of Foot and Ankle Bone and Joint Kinematics Measured With Biplanar Videoradiography and Manual Scientific Rotoscoping.

Front Bioeng Biotechnol 2020 10;8:106. Epub 2020 Mar 10.

School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.

The intricate motion of the small bones of the feet are critical for its diverse function. Accurately measuring the 3-dimensional (3D) motion of these bones has attracted much attention over the years and until recently, was limited to invasive techniques or quantification of functional segments using multi-segment foot models. Biplanar videoradiography and model-based scientific rotoscoping offers an exciting alternative that allows us to focus on the intricate motion of individual bones in the foot. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075816PMC

Evaluation of characteristics of thyroid nodules on contrast-enhanced ultrasonography: a retrospective analysis of 252 cases.

Med Ultrason 2020 May 19;22(2):164-170. Epub 2020 Feb 19.

Research Institution of Bone tumor, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Aim: This study investigated the enhancement patterns observed on contrast-enhanced ultrasound (CEUS) images for differentiating thyroid nodules.

Material And Methods: A retrospective review was conducted of CEUS cine loops of 252 nodules by two independent readers. Seven categories of enhancement patterns were identified: concentric hypoenhancement; heterogeneous hypoenhancement; hypoenhancement with sharp margin; homogeneous hyper/isoenhancement; hyper/isoenhancement with ring-like vascularity; island-like enhancement; and no perfusion. Read More

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http://dx.doi.org/10.11152/mu-2252DOI Listing

Focal cemento-osseous dysplasia: A case report with a review of literature.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S15-S18. Epub 2020 Feb 28.

Department of Oral and Maxillofacial Pathology, YMT Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Cemento-osseous dysplasia (COD) is the most prevalent lesion and presents as an asymptomatic, mixed radiolucent/radiopaque lesion in the tooth-bearing region of the jawbones. Histological features of COD include a cellular connective tissue stroma interspersed by the islands of woven or lamellar bone and cementum-like calcifications. Radiographically, the early COD lesions appear radiolucent, whereas in the mature lesions, radiopacities are observed surrounded by a thin rim of radiolucency. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_349_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069140PMC
February 2020

Development and Validation of a Semiquantitative Food Frequency Questionnaire to Assess Dietary Intake in 40-65-Year-Old Mexican Women.

Ann Nutr Metab 2020 17;76(1):73-82. Epub 2020 Mar 17.

Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, IDISBA and CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), Palma, Spain,

Background And Aims: Food frequency questionnaires (FFQ) have been widely used in epidemiologic studies since 1990s, but instruments need to be validated. The aim of this work was to create and assess the validity and reproducibility of an interview administered FFQ to be used in a Mexican women's bone health cohort study, located in Monterrey city, Mexico.

Methods: Validation of FFQ formed by 11 food groups and 136 food and beverage items was performed on 40-65-year-old Mexican women (n = 200) by applying 2 FFQ (test method) and six 24-h dietary recalls (24hR, reference method; 1 per season on weekdays and 2 on weekends). Read More

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http://dx.doi.org/10.1159/000506920DOI Listing

Autografts vs Synthetics for Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis.

Orthop Surg 2020 Apr 16;12(2):378-387. Epub 2020 Mar 16.

Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, Rhode Island, USA.

To describe the outcomes of autografts and synthetics in anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) reconstruction with respect to instrumented laxity measurements, patient-reported outcome scores, complications, and graft failure risk. We searched PubMed, Cochrane Library, and EMBASE for published randomized controlled trials (RCT) and case controlled trials (CCTs) to compare the outcomes of the autografts versus synthetics after cruciate ligament reconstruction. Data analyses were performed using Cochrane Collaboration RevMan 5. Read More

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http://dx.doi.org/10.1111/os.12662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189042PMC

Functional Characteristics of the Mouse Promoter in Various Tissues Before and After Irradiation.

DNA Cell Biol 2020 May 13;39(5):790-800. Epub 2020 Mar 13.

Laboratory for Physiology of Hematopoiesis, National Research Center for Hematology of the Ministry of Health of the Russian Federation, Moscow, Russia.

Interleukin-1 beta () is a key inducer of inflammation and an important factor in the regulation of hematopoietic stem cells and mesenchymal stromal progenitors. Irradiation of mice with ionizing radiation has been shown to induce a lasting increase in IL1B concentration in peripheral blood. One of the possible mechanisms may be demethylation of CpG cytosines in the promoter, which has not been characterized in detail for the mouse. Read More

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http://dx.doi.org/10.1089/dna.2019.5310DOI Listing

Evolution and refinements of a dorsal adipofascial digital artery perforator flap.

Injury 2020 Mar 9. Epub 2020 Mar 9.

Department of Plastic Surgery, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Soft tissue defects to the dorsum of fingers are quite demanding for the reconstructive surgeon especially in the cases that bone and extensor tendons are exposed. The purpose of our study was to describe a new adipofascial island flap by a single dorsal digital perforator (dorsal adipofascial digital artery perforator, DADAP).

Materials: Methods: In 8 patients (7 male, 1 female), 12 soft tissue defects to the dorsum of the fingers (3 index, 6 middle, 2 ring, 1 little finger), ranging from 1 × 2 cm to 2 × 4 cm, were reconstructed using the DADAP flap. Read More

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http://dx.doi.org/10.1016/j.injury.2020.03.023DOI Listing

Indications for Hematopoietic Cell Transplantation and Immune Effector Cell Therapy: Guidelines from the American Society for Transplantation and Cellular Therapy.

Biol Blood Marrow Transplant 2020 Mar 9. Epub 2020 Mar 9.

BMT & Cellular Therapy Program, Medical College of Wisconsin, Milwaukee, Wisconsin; Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin.

The American Society for Transplantation and Cellular Therapy (ASTCT) published its first white paper on indications for autologous and allogeneic hematopoietic cell transplantation (HCT) in 2015. It was identified at the time that periodic updates of indications would be required to stay abreast with state of the art and emerging indications and therapy. In recent years the field has not only seen an improvement in transplantation technology, thus widening the therapeutic scope of HCT, but additionally a whole new treatment strategy using modified immune effector cells, including chimeric antigen receptor T cells and engineered T-cell receptors, has emerged. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.03.002DOI Listing