12,509 results match your criteria Bone Island


USP6 Gene Rearrangement by FISH Analysis in Cranial Fasciitis: A Report of Three Cases.

Head Neck Pathol 2019 Feb 13. Epub 2019 Feb 13.

Touro College of Dental Medicine at New York Medical College, 19 Skyline Drive Rm 427, Hawthorne, NY, 10532, USA.

Cranial fasciitis (CF) is an uncommon benign myofibroblastic proliferation involving the soft and hard tissues of the cranium. It typically occurs in the pediatric population with a male predilection (male-to-female ratio 1.5:1). Read More

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http://dx.doi.org/10.1007/s12105-019-01018-0DOI Listing
February 2019

Analysis of false start bone lesions produced by an electrical oscillating autopsy saw.

Int J Legal Med 2019 Feb 13. Epub 2019 Feb 13.

Institut Universitaire d'Anthropologie Médico-Légale, Faculté de Médecine, Université Côte d'Azur, 28, Avenue de Valombrose, 06107, Nice CEDEX 2, France.

Postmortem dismemberment results from the use of sharp or sharp blunt instruments. Saws produce specific bone lesions, and the observation of certain saw mark features allows for the recognition of certain characteristics of the saw and its teeth. At autopsy, sections of the skull and other parts of the skeleton are usually achieved using an electrical oscillating autopsy saw. Read More

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http://dx.doi.org/10.1007/s00414-019-02008-1DOI Listing
February 2019

Myelofibrosis osteoclasts are clonal and functionally impaired.

Blood 2019 Feb 11. Epub 2019 Feb 11.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States;

Bone marrow (BM) sclerosis is commonly found in patients with late stage myelofibrosis (MF). Because osteoclasts (OC) and osteoblasts play a key role in bone remodeling, and MF monocytes, the OC precursors, are derived from the neoplastic clone, we wondered whether decreased OC numbers or impairment in their osteolytic function affects the development of osteosclerosis. Analysis of BM biopsies from 50 MF patients showed increased numbers of multinucleated tartrate-resistant acid phosphatase (TRAP)/cathepsin K-positive OC expressing phosphorylated Janus kinase (JAK)-2. Read More

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http://dx.doi.org/10.1182/blood-2018-10-878926DOI Listing
February 2019

Pioglitazone Therapy in Patients With Stroke and Prediabetes: A Post Hoc Analysis of the IRIS Randomized Clinical Trial.

JAMA Neurol 2019 Feb 7. Epub 2019 Feb 7.

Department of Medicine, Yale School of Medicine, New Haven, Connecticut.

Importance: In the Insulin Resistance Intervention After Stroke (IRIS) randomized clinical trial, pioglitazone, an insulin-sensitizing agent, reduced the risk for recurrent stroke or myocardial infarction (MI) among patients with insulin resistance. However, insulin resistance is not commonly measured in clinical practice.

Objective: To analyze the effects of pioglitazone in patients with good adherence as well as intention-to-treat effects of pioglitazone in patients with prediabetes in the IRIS trial. Read More

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2019.0079DOI Listing
February 2019
3 Reads

Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the Gene.

Int J Genomics 2019 8;2019:7076513. Epub 2019 Jan 8.

Key Laboratory of Orthopaedics & Traumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.

Purpose: gene is one of the key factors in regulating bone absorption. Although there are reports showing diverse transcription factors, epigenetic modification could be responsible for regulating gene expression. There is still little exploration on promoter methylation status of gene in osteoporotic bone tissues. Read More

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http://dx.doi.org/10.1155/2019/7076513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341240PMC
January 2019
1 Read

Knowledge, attitudes, beliefs, and health behaviors of bone health among Caribbean Hispanic/Latino adults.

Arch Osteoporos 2019 Feb 4;14(1):14. Epub 2019 Feb 4.

Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, 3 Solomont Way, Suite 4, Lowell, MA, 01854, USA.

Few studies have examined knowledge and perceptions of osteoporosis among Caribbean Latino adults. Confusion regarding the term osteoporosis was noted. Doctors were viewed as trusted sources of health information, although descriptions of a paradoxical relationship emerged. Read More

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http://dx.doi.org/10.1007/s11657-019-0566-5DOI Listing
February 2019
2 Reads

When a lost "Petit Prince" meets Antoine de Saint Exupéry: An anthropological case report.

Forensic Sci Int 2019 Jan 19. Epub 2019 Jan 19.

Institut National de Police Scientifique, Laboratoire de Marseille, France.

This case study reports the anthropological analysis of bones remains discovered on Riou Island (Marseille, France) and the story of two World War II fighter pilots. The discovery of bones on "The Fountain of the Greeks" square on Riou Island occurred in the 1960's and a first anthropological study described a 35-year-old man, about 1.77 m tall, buried since an estimated period between the 13th and 16th centuries. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.01.015DOI Listing
January 2019

Hyperhomocysteinemia induced endothelial progenitor cells dysfunction through hyper-methylation of CBS promoter.

Biochem Biophys Res Commun 2019 Feb 23;510(1):135-141. Epub 2019 Jan 23.

Bone Biology Laboratory, Department of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA. Electronic address:

Bone marrow (BM)-derived endothelial progenitor cells (EPCs) are the key players in angiogenesis and vascular function. Cystathionine-β-synthase (CBS), an HS-generating enzyme in methionine metabolism, regulates the function of these EPCs. This study aims to examine whether CBS hyper-methylation contributes to the bone marrow endothelial progenitor cell (BM-EPCs) function and subsequent bone blood flow in mice fed with a high methionine diet (HMD). Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.066DOI Listing
February 2019

Evaluating the bioactivity of a hydroxyapatite-incorporated polyetheretherketone biocomposite.

Authors:
Rui Ma Dagang Guo

J Orthop Surg Res 2019 Jan 25;14(1):32. Epub 2019 Jan 25.

State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.

Background: Polyetheretherketone (PEEK) exhibits stable chemical properties, excellent biocompatibility, and rational mechanical properties that are similar to those of human cortical bone, but the lack of bioactivity impedes its clinical application.

Methods: In this study, hydroxyapatite (HA) was incorporated into PEEK to fabricate HA/PEEK biocomposite using a compounding and injection-molding technique. The tensile properties of the prepared HA/PEEK composites (HA content from 0 to 40 wt%) were tested to choose an optimal HA content. Read More

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https://josr-online.biomedcentral.com/articles/10.1186/s1301
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http://dx.doi.org/10.1186/s13018-019-1069-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347847PMC
January 2019
1 Read

Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva.

Ocul Oncol Pathol 2019 Jan 22;5(1):28-35. Epub 2018 May 22.

Eyelid Experts, Palm Beach Gardens, Florida, USA.

An 87-year-old woman not known to have either a lymphoma or leukemia developed a left multinodular, fish-flesh superior epibulbar and forniceal mass. A biopsy disclosed a blastic tumor with scattered multinucleated immature megakaryoblasts. Immunophenotyping of bone marrow cells revealed strong positivity for CD7, CD31, CD43, CD45, CD61, and CD117; CD71, myeloperoxidase, and lysozyme were also positive in scattered cells. Read More

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https://www.karger.com/Article/FullText/488057
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http://dx.doi.org/10.1159/000488057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341420PMC
January 2019
4 Reads

Maea expressed by macrophages, but not erythroblasts, maintains postnatal murine bone marrow erythroblastic islands.

Blood 2019 Jan 23. Epub 2019 Jan 23.

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY, United States;

The erythroblastic island (EI), formed by a central macrophage and developing erythroblasts, was first described decades ago and recently shown to play an in vivo role in homeostatic and pathological erythropoiesis. The exact molecular mechanisms, however, mediating the interactions between macrophages and erythroblasts remain unclear. crophage-rythroblast ttacher (Maea) has previously been suggested to mediate homophilic adhesion bounds bridging macrophages and erythroblasts. Read More

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http://dx.doi.org/10.1182/blood-2018-11-888180DOI Listing
January 2019

2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections.

J Orthop Res 2019 Jan 22. Epub 2019 Jan 22.

Department of Orthopaedic Surgery at St. Olavs Hospital, Trondheim, Norway.

Biofilm-associated implant-related bone and joint infections are clinically important due to the extensive morbidity, cost of care and socioeconomic burden that they cause. Research in the field of biofilms has expanded in the past two decades, however, there is still an immense knowledge gap related to many clinical challenges of these biofilm-associated infections. This subject was assigned to the Biofilm Workgroup during the second International Consensus Meeting on Musculoskeletal Infection held in Philadelphia USA (ICM 2018) (https://icmphilly. Read More

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http://doi.wiley.com/10.1002/jor.24229
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http://dx.doi.org/10.1002/jor.24229DOI Listing
January 2019
7 Reads
2.986 Impact Factor

controls chikungunya virus-specific pathogenic T cell IFNγ Th1 stimulation in mice.

Life Sci Alliance 2019 Feb 21;2(1). Epub 2019 Jan 21.

Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore

Chikungunya virus (CHIKV) has been a worldwide threat since its reemergence in La Reunion Island in 2004. Expression of the interferon-stimulated protein correlates with viral load burden in patients, and studies in mice have demonstrated its role to limit disease severity against CHIKV infection. Using mice, we aimed to understand the contribution of to the T-cell immune response against CHIKV. Read More

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http://www.life-science-alliance.org/lookup/doi/10.26508/lsa
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http://dx.doi.org/10.26508/lsa.201900298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342136PMC
February 2019
2 Reads

Alterations in Joint Angular Velocity Following Traumatic Knee Injury in Ovine Models.

Ann Biomed Eng 2019 Jan 17. Epub 2019 Jan 17.

McCaig Institute for Bone & Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Little effort has been directed towards the consequence of an injury on joint angular velocity. We hypothesized that the magnitude of knee joint angular velocity would be decreased after injury. Four injury groups were investigated in an ovine model: (1) anterior cruciate ligament (ACL) and medial collateral ligament (MCL) transection (ACL/MCL Tx) (n = 5), (2) lateral meniscectomy (Mx) (n = 5), (3) partial ACL transection (p-ACL Tx) (n = 5), and (4) partial-ACL and MCL transection (p-ACL/MCL Tx) (n = 5). Read More

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http://dx.doi.org/10.1007/s10439-019-02203-6DOI Listing
January 2019
6 Reads

Treatment of fingertip avulsion injuries using two periposition pedicled flaps.

J Plast Reconstr Aesthet Surg 2019 Jan 9. Epub 2019 Jan 9.

The Department of Bone Oncology, Tianjin Hospital, No.406 Jiefang Road, Tianjin 300211, China. Electronic address:

We described a treatment of fingertip avulsion injury by two periposition pedicled flaps, the reversed pedicle island flap of dorsal branch of proper digital artery and the cross-finger flap. From February 2009 to January 2017, 22 patients (22 fingers) with fingertip avulsion injury were treated with two periposition pedicled flaps, 14 male and 8 female, aged from 17 to 47 years (mean 32 ± 9 years). All of the patients were followed up more than 6 months after operations (mean 9. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17486815193001
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http://dx.doi.org/10.1016/j.bjps.2018.12.051DOI Listing
January 2019
3 Reads

Peripheral ameloblastoma with neoplastic osseous invasion versus peripheral intraosseous ameloblastoma: A challenging diagnosis.

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):396-400

Department of Oral Pathology and Microbiology, Amrita School of Dentistry, AIMS, Amrita Vishwa Vidhyapeetham, Kochi, Kerala, India.

Peripheral ameloblastoma, a soft-tissue analogue of intraosseous ameloblastoma, is a rare odontogenic tumor with histologic characteristics of ameloblastoma. In contrast to conventional ameloblastoma, peripheral ameloblastomas are considered as innocuous lesions which usually do not show invasion of the underlying structures. Rarely, intraosseous ameloblastoma which penetrates the alveolar bone can fuse with the overlying oral epithelium and eventually manifest as an exophytic peripheral lesion. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_130_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306599PMC
January 2019

The impact of orbital bony or fat decompression on the outcome of strabismus surgery in patients with Graves' ophthalmopathy.

J Formos Med Assoc 2019 Jan 7;118(1 Pt 3):387-394. Epub 2018 Jul 7.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; School of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: To compare the outcomes of strabismus surgery in patients with Graves' ophthalmopathy (GO) who had undergone bone removal orbital decompression (BROD) or fat removal orbital decompression (FROD) with those who had not undergone any orbital decompression.

Methods: The records of patients with GO who underwent strabismus surgery over a period of 66 months were retrospectively reviewed.

Results: Eighty-nine patients with a mean age of 55. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.06.009DOI Listing
January 2019
2 Reads

Dorset Pre-Inuit and Beothuk foodways in Newfoundland, ca. AD 500-1829.

PLoS One 2019 7;14(1):e0210187. Epub 2019 Jan 7.

Department of Archaeology, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

Archaeological research on the Canadian island of Newfoundland increasingly demonstrates that the island's subarctic climate and paucity of terrestrial food resources did not restrict past Pre-Inuit (Dorset) and Native American (Beothuk) hunter-gatherer populations to a single subsistence pattern. This study first sought to characterize hunter-gatherer diets over the past 1500 years; and second, to assess the impact of European colonization on Beothuk lifeways by comparing the bone chemistry of Beothuk skeletal remains before and after the intensification of European settlement in the early 18th century. We employed radiocarbon dating and stable carbon and nitrogen isotope ratio analysis of bulk bone collagen from both Dorset (n = 9) and Beothuk (n = 13) cultures, including a naturally mummified 17th century Beothuk individual. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210187PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322756PMC
January 2019
5 Reads

Focus of infection and microbiological etiology in community-acquired infections in hospitalized adult patients in the Faroe Islands.

BMC Infect Dis 2019 Jan 7;19(1):16. Epub 2019 Jan 7.

Medical Department, Infectious Diseases Division, National Hospital of the Faroe Islands, JC. Svabosgøta 41-49, Tórshavn, Faroe Islands.

Background: The aim of the present study was to gain national data on the clinical and microbiological characteristics of community-acquired infections in the Faroe Islands and to compare these data with data from other geographical areas.

Methods: A prospective, observational study involving all patients > = 16 years admitted at the Department of Medicine at the National Hospital, Torshavn, Faroe Islands from October 2013 until April 2015.

Results: Of 5279 admissions, 1054 cases were with community-acquired infection and were included in the study. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3650-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322335PMC
January 2019
1 Read

Early supplemental α2-macroglobulin attenuates cartilage and bone damage by inhibiting inflammation in collagen II-induced arthritis model.

Int J Rheum Dis 2019 Jan 4. Epub 2019 Jan 4.

The Second Hospital of Shanxi Medical University, Taiyuan, China.

Objective: To determine if early supplemental intra-articular α2-macroglobulin (A2M) has a chondroprotective effect in a collagen II-induced arthritis (CIA) mice model.

Methods: DBA/1 mice were randomized into four groups (n = 15/group): (a) CIA + 1.2 μg of A2M; (b) CIA + 0. Read More

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http://dx.doi.org/10.1111/1756-185X.13457DOI Listing
January 2019

Involvement of tumor necrosis factor alpha in steroid-associated osteonecrosis of the femoral head: friend or foe?

Stem Cell Res Ther 2019 Jan 3;10(1). Epub 2019 Jan 3.

Key laboratory of Orthopaedics and Traumatology of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.

Background: The etiology and pathology osteonecrosis of the femoral head (ONFH) are not completely clarified. As a cytokine participating in systemic inflammation, tumor necrosis factor alpha (TNFα) has been shown to be involved in the pathogenesis of ONFH. However, the role of TNFα in ONFH is not clearly clarified. Read More

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http://dx.doi.org/10.1186/s13287-018-1112-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318982PMC
January 2019
1 Read

Possible Contribution of Wnt-Responsive Chondroprogenitors to the Postnatal Murine Growth Plate.

J Bone Miner Res 2019 Jan 2. Epub 2019 Jan 2.

Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Active cell proliferation and turnover in the growth plate is essential for embryonic and postnatal bone growth. We performed a lineage tracing of Wnt/β-catenin signaling responsive cells (Wnt-responsive cells) using Axin2 ;Rosa26ZsGreen mice and found a novel cell population that resides in the outermost layer of the growth plate facing the Ranvier's groove (RG; the perichondrium adjacent to growth plate). These Wnt-responsive cells rapidly expanded and contributed to formation of the outer growth plate from the neonatal to the growing stage but stopped expanding at the young adult stage when bone longitudinal growth ceases. Read More

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http://doi.wiley.com/10.1002/jbmr.3658
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http://dx.doi.org/10.1002/jbmr.3658DOI Listing
January 2019
4 Reads

Practice variation in total hip arthroplasty versus hemiarthroplasty for treatment of fractured neck of femur in Australia.

Bone Joint J 2019 Jan;101-B(1):92-95

Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, Australia.

Aims: Displaced femoral neck fractures (FNF) may be treated with partial (hemiarthroplasty, HA) or total hip arthroplasty (THA), with recent recommendations advising that THA be used in community-ambulant patients. This study aims to determine the association between the proportion of FNF treated with THA and year of surgery, day of the week, surgeon practice, and private versus public hospitals, adjusting for known confounders.

Patients And Methods: Data from 67 620 patients in the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) from 1999 to 2016 inclusive were used to generate unadjusted and adjusted analyses of the associations between patient, time, surgeon and institution factors, and the proportion of FNF treated with THA. Read More

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https://online.boneandjoint.org.uk/doi/10.1302/0301-620X.101
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http://dx.doi.org/10.1302/0301-620X.101B1.BJJ-2018-0666.R1DOI Listing
January 2019
7 Reads

Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone.

Case Rep Pathol 2018 26;2018:4160925. Epub 2018 Nov 26.

Professor, Department of Orthopaedics, Zucker/Hofstra North Shore Long Island Jewish, Northwell Health Medical Center, New Hyde Park, NY, USA.

Primary lymphoma of bone (PLB) confined to the epiphysis has only been described in four other patients. Due to the rarity of this entity, diagnosis has often been delayed, leading to mismanagement with adverse clinical consequences. We report a fifth case of primary epiphyseal lymphoma of bone located in the left distal medial femoral epiphysis of a 13-year-old boy. Read More

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https://www.hindawi.com/journals/cripa/2018/4160925/
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http://dx.doi.org/10.1155/2018/4160925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287168PMC
November 2018
6 Reads

MeCP2 promotes endothelial-to-mesenchymal transition in human endothelial cells by downregulating BMP7 expression.

Exp Cell Res 2019 Feb 28;375(1):82-89. Epub 2018 Dec 28.

Department of Geriatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, China. Electronic address:

Endothelial-to-mesenchymal transition (EndMT) plays a pivotal role in the development of organ fibrosis and can be induced by TGF-β. It is characterized by the loss of endothelial cell markers and the acquisition of mesenchymal markers. In this study, we found that methyl-CpG binding protein 2 (MeCP2) was increased in TGF-β-induced EndMT, and silencing of MeCP2 inhibited EndMT induction. Read More

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http://dx.doi.org/10.1016/j.yexcr.2018.12.020DOI Listing
February 2019

Associations between vitamin D deficiency, musculoskeletal health, and cardiometabolic risk among community-living people in Taiwan: Age and sex-specific relationship.

Medicine (Baltimore) 2018 Dec;97(52):e13886

Center for Geriatrics and Gerontology, Taipei Veteran General Hospital.

The role of serum vitamin D (Vit D) in cardiometabolic and muscle health remains unclear. The study aimed to evaluate associations of Vit D and factors of healthy aging among community-living middle-aged and older people in Taiwan. Analytic data on 1839 community-living older adults were excerpted from I-Lan Longitudinal Aging Study. Read More

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http://dx.doi.org/10.1097/MD.0000000000013886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314705PMC
December 2018
1 Read

Accelerated Knee Osteoarthritis is Characterized by Destabilizing Meniscal Tears and Pre-Radiographic Structural Disease Burden.

Arthritis Rheumatol 2018 Dec 28. Epub 2018 Dec 28.

Division of Rheumatology, Tufts Medical Center, 800 Washington StreetTufts Med Ctr #406, 02111, Boston, Massachusetts, United States.

Objective: To determine if accelerated knee osteoarthritis (KOA) is preceded and characterized by destabilizing meniscal tears or other pathologic changes.

Methods: We selected 3 sex-matched groups from the first 48 months of the Osteoarthritis Initiative who had a knee without KOA at baseline (Kellgren-Lawrence [KL]<2): Accelerated KOA (AKOA) developed KL grade≥3, typical KOA increased radiographic scoring, and no KOA had the same KL grade over time. An index visit was the visit when the radiographic criteria for AKOA and typical KOA were met (no KOA was matched to AKOA). Read More

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http://dx.doi.org/10.1002/art.40826DOI Listing
December 2018
3 Reads

Dengue in Taiwan: Pointing the finger at Aedes aegypti.

Biomed J 2018 Oct 12;41(5):279-282. Epub 2018 Nov 12.

Staff Writer at the Biomedical Journal, 56 Dronningens Gate, 7012 Trondheim, Norway. Electronic address:

In this issue of the Biomedical Journal we explore the history of dengue infection in Taiwan and what current trends have to say about the vector responsible for transmitting the disease on the island. We focus on original research reporting the development of a new perfusion bioreactor to engineer bone from human cord blood stem cells. Finally, we look at trends in osteoporosis in Taiwan and how they highlight the success of public health campaigns. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170183059
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http://dx.doi.org/10.1016/j.bj.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306303PMC
October 2018
7 Reads

Pazopanib for treatment of advanced malignant and dedifferentiated solitary fibrous tumour: a multicentre, single-arm, phase 2 trial.

Lancet Oncol 2019 Jan 18;20(1):134-144. Epub 2018 Dec 18.

Department of Medical Oncology, University Hospital of Canarias, Tenerife, Spain.

Background: A solitary fibrous tumour is a rare soft-tissue tumour with three clinicopathological variants: typical, malignant, and dedifferentiated. Preclinical experiments and retrospective studies have shown different sensitivities of solitary fibrous tumour to chemotherapy and antiangiogenics. We therefore designed a trial to assess the activity of pazopanib in a cohort of patients with malignant or dedifferentiated solitary fibrous tumour. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183067
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http://dx.doi.org/10.1016/S1470-2045(18)30676-4DOI Listing
January 2019
12 Reads

Paradise lost: Evidence for a devastating metabolic bone disease in an insular Pleistocene deer.

Int J Paleopathol 2018 Dec 17;24:213-226. Epub 2018 Dec 17.

Naturalis Biodiversity Center, Leiden, the Netherlands.

Purpose: This communication reports skeletal pathology in a Pleistocene endemic deer from the Mavromouri caves of Crete.

Materials: 287 bones and bone fragments from Mavromouri caves are compared to 2986 bones from Liko Cave.

Methods: Bones were evaluated macroscopically, and measurements were made of morphometric characteristics of limb long bones. Read More

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http://dx.doi.org/10.1016/j.ijpp.2018.12.003DOI Listing
December 2018
1 Read

[Application of deep circumflex iliac artery based iliac-internal oblique musculofascial chimeric flaps in reconstruction of complex oromandibular defects].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Dec;32(12):1567-1571

Department of Head and Neck Surgery, Cancer Hospital of Shantou University Medical College, Shantou Guangdong, 515031, P.R.China.

Objective: To evaluate the reliability and effectiveness of a deep circumflex iliac artery based iliac-internal oblique musculofascial chimeric flap (DCIA-IIOF) in reconstruction of complex oromandibular defect.

Methods: Between January 2010 and December 2015, DCIA-IIOFs were used to repair complex oromandibular defects in 11 patients. There were 8 males and 3 females, with an age of 27-75 years (median, 56 years). Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201806023
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http://dx.doi.org/10.7507/1002-1892.201806023DOI Listing
December 2018
10 Reads

Iron Regulation: Macrophages in Control.

Pharmaceuticals (Basel) 2018 Dec 14;11(4). Epub 2018 Dec 14.

Medical University of Vienna, Center for Pathobiochemistry and Genetics, Vienna 1090, Austria.

Macrophages are sentinel cells of the innate immune system and have important functions in development, tissue homeostasis, and immunity. These phylogenetically ancient cells also developed a variety of mechanisms to control erythropoiesis and the handling of iron. Red pulp macrophages in the spleen, Kupffer cells in the liver, and central nurse macrophages in the bone marrow ensure a coordinated metabolism of iron to support erythropoiesis. Read More

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http://dx.doi.org/10.3390/ph11040137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316009PMC
December 2018
1 Read

Plasmodium falciparum gametocyte-infected erythrocytes do not adhere to human primary erythroblasts.

Sci Rep 2018 Dec 14;8(1):17886. Epub 2018 Dec 14.

Inserm U1016, Institut Cochin, Paris, France.

Plasmodium falciparum gametocytes, the sexual stages responsible for malaria parasite transmission, develop in the human bone marrow parenchyma in proximity to the erythroblastic islands. Yet, mechanisms underlying gametocytes interactions with these islands are unknown. Here, we have investigated whether gametocyte-infected erythrocytes (GIE) adhere to erythroid precursors, and whether a putative adhesion may be mediated by a mechanism similar to the adhesion of erythrocytes infected with P. Read More

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http://dx.doi.org/10.1038/s41598-018-36148-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294825PMC
December 2018

Antibiotic elution and mechanical property of TiO nanotubes functionalized PMMA-based bone cements.

J Mech Behav Biomed Mater 2019 Mar 23;91:91-98. Epub 2018 Nov 23.

Institute of Chemical and Engineering Sciences, A⁎STAR (Agency for Science, Technology and Research), 1 Pesek Road, Singapore 627833, Jurong Island, Singapore; Department of Chemical and Biomolecular Engineering, The National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore. Electronic address:

To overcome the disadvantage of current antibiotic bone cements with low drug elution efficiency, the hollow nanostructured titanium-dioxide (TiO) nanotubes (TNTs) were formulated with antibiotic loaded bone cement to create nano diffusion networks, enabling enhanced release of antibiotic. By incorporation of TNTs into Poly(methyl methacrylate) (PMMA) based bone cement, more than 50% of loaded antibiotic (such as gentamicin or vancomycin) could be released in two months. As comparison, only about 5% of total drug release was achieved in the absence of TNTs. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.11.020DOI Listing
March 2019
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Convergent evolution of an extreme dietary specialisation, the olfactory system of worm-eating rodents.

Sci Rep 2018 Dec 13;8(1):17806. Epub 2018 Dec 13.

Institut des Sciences de l'Evolution (ISEM, UMR 5554 CNRS-IRD-UM), Université de Montpellier, Place E. Bataillon - CC 064 - 34095, Montpellier Cedex 5, France.

Turbinal bones are key components of the mammalian rostrum that contribute to three critical functions: (1) homeothermy, (2) water conservation and (3) olfaction. With over 700 extant species, murine rodents (Murinae) are the most species-rich mammalian subfamily, with most of that diversity residing in the Indo-Australian Archipelago. Their evolutionary history includes several cases of putative, but untested ecomorphological convergence, especially with traits related to diet. Read More

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http://www.nature.com/articles/s41598-018-35827-0
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http://dx.doi.org/10.1038/s41598-018-35827-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293001PMC
December 2018
5 Reads

Low bone mineral density is associated with an elevated risk of developing increased arterial stiffness: A 10-year follow-up of Japanese women from the Japanese Population-based Osteoporosis (JPOS) cohort study.

Maturitas 2019 Jan 11;119:39-45. Epub 2018 Nov 11.

Department of Public Health, Kindai University Faculty of Medicine, 377-2 Oonohigashi, Osaka-Sayama, Osaka, 589-8511, Japan. Electronic address:

Objective: Only a few longitudinal studies have assessed the relationship between bone mineral density (BMD) and arteriosclerosis. This study aimed to determine whether low BMD at baseline is associated with the development of increased arterial stiffness, as evaluated by brachial-ankle pulse wave velocity (baPWV), in Japanese women.

Methods: A baPWV value of ≥1800 cm/s was adopted as the criterion for increased arterial stiffness, i. Read More

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http://dx.doi.org/10.1016/j.maturitas.2018.11.001DOI Listing
January 2019
2 Reads

A combined chemical imaging approach using (MC) LA-ICP-MS and NIR-HSI to evaluate the diagenetic status of bone material for Sr isotope analysis.

Anal Bioanal Chem 2019 Jan 4;411(3):565-580. Epub 2018 Dec 4.

Department of Chemistry, Division of Analytical Chemistry, VIRIS Laboratory, University of Natural Resources and Life Sciences, Vienna, Konrad-Lorenz-Str. 24, 3430, Tulln, Austria.

This paper presents a combination of elemental and isotopic spatial distribution imaging with near-infrared hyperspectral imaging (NIR-HSI) to evaluate the diagenetic status of skeletal remains. The aim is to assess how areas with biogenic n(Sr)/n(Sr) isotope-amount ratios may be identified in bone material, an important recorder complementary to teeth. Elemental (C, P, Ca, Sr) and isotopic (n(Sr)/n(Sr)) imaging were accomplished via laser ablation (LA) coupled in a split stream to a quadrupole inductively coupled plasma mass spectrometer (ICP-QMS) and a multicollector inductively coupled plasma mass spectrometer (MC ICP-MS) (abbreviation for the combined method LASS ICP-QMS/MC ICP-MS). Read More

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http://dx.doi.org/10.1007/s00216-018-1489-5DOI Listing
January 2019

Evaluation of the Possible Synergic Regenerative Effects of Platelet-Rich Plasma and Hydroxyapatite/Zirconia in the Rabbit Mandible Defect Model.

Iran J Med Sci 2018 Nov;43(6):633-644

Tissue Engineering Lab, Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Platelet-rich plasma (PRP) and bioceramics such as hydroxyapatite (HA) and zirconium oxide (ZrO) are used to reconstruct mandibular defects. We sought to determine the synergistic effects of HA/ZrO and PRP and compare their osteogenic activity.

Methods: ZrO scaffolds were constructed by the slurry method and were then coated with HA and impregnated by PRP/heparan sulfate (HS). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230930PMC
November 2018
1 Read

Larvae of Huxelhydrus syntheticus Sharp, 1882 (Coleoptera: Dytiscidae: Bidessini).

Zootaxa 2018 Nov 20;4524(1):121-131. Epub 2018 Nov 20.

University of Buenos Aires, Faculty of Exact and Natural Sciences, Department of Biodiversity and Experimental Biology, Laboratory of Entomology, Buenos Aires, Argentina. CONICET-University of Buenos Aires, Institute of Biodiversity and Experimental and Applied Biology (IBBEA), Buenos Aires, Argentina..

The three larval instars of Huxelhydrus syntheticus Sharp, 1882, the only species of the New Zealand endemic genus Huxelhydrus Sharp, 1882, are described and illustrated including detailed morphometric and chaetotaxic analyses of the cephalic capsule, head appendages, legs, last abdominal segment and urogomphi. Larvae of this species are characterized by the absence of the primary pore ABc, shared with all other known Bidessini larvae and therefore representing a potential synapomorphy of the tribe. Third instars of Huxelhydrus can be separated from those of all other known Bidessini genera by the following combination of characters: larger size, mandibular pore MNa located in a clearly distal position with respect to pore MNb, and presence of secondary setae on dorsal surface of protarsus, on posteroventral surface of all tarsi, and on urogomphus. Read More

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http://dx.doi.org/10.11646/zootaxa.4524.1.9DOI Listing
November 2018

Scolopsis meridiana, a new species of monocle bream (Perciformes: Nemipteridae) from northern Australia.

Zootaxa 2018 Oct 16;4500(2):222-234. Epub 2018 Oct 16.

Graduate School of Fisheries, Kagoshima University, 4-50-20 Shimoarata, Kagoshima 890-0065, Japan.

Scolopsis meridiana n. sp., described from 30 specimens collected from northern Australia, is closely related to S. Read More

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http://dx.doi.org/10.11646/zootaxa.4500.2.4DOI Listing
October 2018
1 Read

The RSNA Pediatric Bone Age Machine Learning Challenge.

Radiology 2019 Feb 27;290(2):498-503. Epub 2018 Nov 27.

From the Department of Radiology, Stanford University, 300 Pasteur Dr, MC 5105, Stanford, CA 94305 (S.S.H.); Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio (L.M.P.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, Mass (J.K.C.); Massachusetts General Hospital & Brigham and Women's Hospital Center for Clinical Data Science, Boston, Mass (A.B.M., K.A.); Department of Radiology, University of Toronto, Toronto, Ontario, Canada (A.B.); Department of Radiology, St. Michael's Hospital, Toronto, Ontario, Canada (M.C.); Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI (I.P.); Universidade Federal de Goiás, Goiânia, Brazil (L.A.P., R.T.S.); Universidade Federal de São Paulo, São Paulo, Brazil (N.A., F.C.K.); Visiana, Hørsholm, Denmark (H.H.T.); MD.ai, New York, NY (L.C.); Department of Radiology, Weill Cornell Medicine, New York, NY (G.S.) Department of Radiology, University of California-San Francisco, San Francisco, Calif (M.D.K.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); and Department of Radiology, Thomas Jefferson University, Philadelphia, Pa (A.E.F.).

Purpose The Radiological Society of North America (RSNA) Pediatric Bone Age Machine Learning Challenge was created to show an application of machine learning (ML) and artificial intelligence (AI) in medical imaging, promote collaboration to catalyze AI model creation, and identify innovators in medical imaging. Materials and Methods The goal of this challenge was to solicit individuals and teams to create an algorithm or model using ML techniques that would accurately determine skeletal age in a curated data set of pediatric hand radiographs. The primary evaluation measure was the mean absolute distance (MAD) in months, which was calculated as the mean of the absolute values of the difference between the model estimates and those of the reference standard, bone age. Read More

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http://dx.doi.org/10.1148/radiol.2018180736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358027PMC
February 2019

Daily rhythms influence the ability of lung-derived extracellular vesicles to modulate bone marrow cell phenotype.

PLoS One 2018 26;13(11):e0207444. Epub 2018 Nov 26.

Department of Medicine, Division of Hematology/Oncology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, United States of America.

Extracellular vesicles (EVs) are important mediators of intercellular communication and have been implicated in myriad physiologic and pathologic processes within the hematopoietic system. Numerous factors influence the ability of EVs to communicate with target marrow cells, but little is known about how circadian oscillations alter EV function. In order to explore the effects of daily rhythms on EV-mediated intercellular communication, we used a well-established model of lung-derived EV modulation of the marrow cell transcriptome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207444PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261033PMC
November 2018
8 Reads

Natural exposure to ultraviolet-B radiation in two species of chameleons from Madagascar.

Zoo Biol 2018 Nov 26;37(6):452-457. Epub 2018 Nov 26.

Durrell Wildlife Conservation Trust, Trinity, Jersey, United Kingdom.

Many reptiles require ultraviolet-B radiation between 290 and 315 nm (UV-B) to synthesize vitamin D3 and process dietary calcium. In captivity, exposure to too little or too much UV-B can result in health problems such as metabolic bone disease. While it is recognized that UV-B is necessary to successfully maintain many reptiles in captivity, the actual levels of UV-B that species are exposed to in nature is poorly known. Read More

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http://dx.doi.org/10.1002/zoo.21459DOI Listing
November 2018

SHP2 regulates intramembranous ossification by modifying the TGFβ and BMP2 signaling pathway.

Bone 2019 Mar 22;120:327-335. Epub 2018 Nov 22.

Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903, United States of America. Electronic address:

SHP2 is a ubiquitously expressed protein tyrosine phosphatase, which is involved in many signaling pathways to regulate the skeletal development. In endochondral ossification, SHP2 is known to modify the osteogenic fate of osteochondroprogenitors and to impair the osteoblastic transdifferentiation of hypertrophic chondrocytes. However, how SHP2 regulates osteoblast differentiation in intramembranous ossification remains incompletely understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282183043
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http://dx.doi.org/10.1016/j.bone.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360127PMC
March 2019
8 Reads

The iron islands: Erythroblastic islands and iron metabolism.

Biochim Biophys Acta Gen Subj 2019 Feb 22;1863(2):466-471. Epub 2018 Nov 22.

Discipline of Anatomy & Histology, School of Medical sciences, Faculty of Medicine, The University of Sydney, Camperdown, Australia; Discipline of Physiology, School of Medical sciences, Faculty of Medicine, The University of Sydney, Camperdown, Australia; Australian Institute for Nanoscience and Nanotechnology, The University of Sydney, Camperdown, Australia. Electronic address:

Background: A healthy human can produce over 1 × 10 blood cells throughout their life. This remarkable amount of biomass requires a concomitantly vast amount of iron to generate functional haemoglobin and functional erythrocytes.

Scope Of The Review: Erythroblasts form multicellular clusters with macrophages in the foetal liver, bone marrow and spleen termed erythroblastic islands. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03044165183034
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http://dx.doi.org/10.1016/j.bbagen.2018.10.019DOI Listing
February 2019
7 Reads

Bone histology provides insights into the life history mechanisms underlying dwarfing in hipparionins.

Sci Rep 2018 Nov 21;8(1):17203. Epub 2018 Nov 21.

Institut Català de Paleontologia Miquel Crusafont (ICP), Campus de la Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.

Size shifts may be a by-product of alterations in life history traits driven by natural selection. Although this approach has been proposed for islands, it has not yet been explored in continental faunas. The trends towards size decrease experienced by some hipparionins constitute a good case study for the application of a life history framework to understand the size shifts on the continent. Read More

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http://dx.doi.org/10.1038/s41598-018-35347-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249282PMC
November 2018

Differential evolution of cerebral and cerebellar fossae in recent Homo: A new methodological approach.

Homo 2018 Nov 9;69(6):289-303. Epub 2018 Oct 9.

Àrea de Prehistòria, Fac. Lletres, Universitat Rovira i Virgili, Av. Catalunya, 35 43002 Tarragona, Spain; Institut Català de Paleoecologia Humana i Evolució Social (IPHES), Carrer Marcel·lí Domingo s/n - Campus Sescelades URV (Edifici W3), 43007 Tarragona, Spain.

The endocranium shows the influence of the shape and development of brain tissues and overall brain modifications. During the late Upper Pleistocene and Holocene smaller brains appeared and the higher position of endinion relative to inion might indicate changes in cerebellar and occipital lobes. In previous studies, the depths of the cerebral and cerebellar fossae were not specifically considered; new tools for quantitatively measuring these irregular, problematic curved areas need to be developed. Read More

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http://dx.doi.org/10.1016/j.jchb.2018.10.001DOI Listing
November 2018
9 Reads