1,210,297 results match your criteria Bone Island


[Update of multimodal therapy in canine osteoarthritis].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):337-345. Epub 2018 Dec 12.

Canine osteoarthritis is a very common disease and the main cause for chronic pain in dogs. Progressive degeneration of joint cartilage, periarticular soft tissues and subchondral bone consecutively lead to osteophytes, inflammation and pain. It is an irreversible process. Read More

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October 2018

Oocyte-Secreted Factors Synergize with FSH to Promote Aromatase Expression in Primary Human Cumulus Cells.

J Clin Endocrinol Metab 2018 Dec 11. Epub 2018 Dec 11.

Department of Physiology and Biophysics, University of Illinois at Chicago.

Context: The role of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) on aromatase regulation is poorly understood in humans.

Objective: Determine GDF9 and BMP15 effects on follicle-stimulating hormone (FSH) stimulation of estradiol production in primary human cumulus granulosa cells (GCs). We hypothesized that the combination of GDF9 and BMP15 potentiates FSH-induced aromatase expression. Read More

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December 2018

Letter to the Editor: Gestational Gigantomastia Complicated by PTHrP-mediated Hypercalcemia.

J Clin Endocrinol Metab 2018 Dec 11. Epub 2018 Dec 11.

Center for Bone Quality: Department of Internal Medicine: division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.

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December 2018

Microneurosurgical Removal of a Cervical Intramedullary Tumor Via Hemilaminoplasty: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey.

Intramedullary tumors of the spinal cord are rare and account for 2% to 8.5% of all central nervous system tumors. In adults, ependymomas are the most common intramedullary tumors. Read More

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December 2018

Comparative Study of MSCA-1 and CD146 Isolated Periosteal Cell Subpopulations.

Cell Physiol Biochem 2018 Dec 12;51(3):1193-1206. Epub 2018 Dec 12.

Department of Oral and Maxillofacial Surgery of the University Hospital of Tübingen, Tübingen,

Background/aims: Periosteal tissue is a valuable source of multipotent stem cells for bone tissue engineering. To characterize these cells in detail, we generated an immortalized human cranial periosteal cell line and observed an increased MSCA-1 and CD146 expression, as well as an earlier and stronger mineralization compared to the parental cells. Further, we detected a higher osteogenic potential of MSCA-1high compared to MSCA-1low cranial periosteal cell (CPC) fractions. Read More

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December 2018

Organ-Specific Fate, Recruitment, and Refilling Dynamics of Tissue-Resident Macrophages during Blood-Stage Malaria.

Cell Rep 2018 Dec;25(11):3099-3109.e3

Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore. Electronic address:

Inflammation-induced disappearance of tissue-resident macrophages represents a key pathogen defense mechanism. Using a model of systemic blood-stage malaria, we studied the dynamics of tissue-resident macrophages in multiple organs to determine how they are depleted and refilled during the course of disease. We show that Plasmodium infection results in a transient loss of embryonically established resident macrophages prior to the parasitemia peak. Read More

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December 2018

IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis.

Cell Rep 2018 Dec;25(11):3021-3035.e5

Department of Hematology, Cancer Center Amsterdam (CCA), Amsterdam UMC, VU Medical Center, Amsterdam, the Netherlands. Electronic address:

Leukemic stem cells (LSCs) are thought to be the major cause of the recurrence of acute myeloid leukemia (AML) due to their potential for self-renewal. To identify therapeutic strategies targeting LSCs, while sparing healthy hematopoietic stem cells (HSCs), we performed gene expression profiling of LSCs, HSCs, and leukemic progenitors all residing within the same AML bone marrow and identified insulin-like growth factor-binding protein 7 (IGFBP7) as differentially expressed. Low IGFBP7 is a feature of LSCs and is associated with reduced chemotherapy sensitivity. Read More

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December 2018
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Phosphatidyl Inositol 3-Kinase (PI3K)-mTOR Inhibitor PKI-402 Inhibits Breast Cancer Induced Osteolysis.

Cancer Lett 2018 Dec 9. Epub 2018 Dec 9.

Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China, 515041. Electronic address:

Bone metastasis causes bone pain and pathological bone fracture in breast cancer patients with a serious complication. Previous studies have demonstrated that a novel phosphatidyl inositol 3-kinase (PI3K)-mTOR inhibitor PKI-402 suppressed the growth of breast cancer cells. However, the role of PKI-402 involved in osteolysis induced by breast cancer remains unclear. Read More

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December 2018

Telomeres in Interstitial Lung Disease: The Short and the Long of It.

Ann Am Thorac Soc 2018 Dec 12. Epub 2018 Dec 12.

Brigham and Women's Hospital, Medicine, Boston, Massachusetts, United States.

Telomeres are repetitive nucleotide sequences that cap linear chromosomes, thereby limiting progressive chromosomal shortening during cell replication. In conjunction with environmental factors, common single nucleotide polymorphisms and rare and ultra-rare telomere-related mutations are associated with accelerated telomere shortening resulting in organ dysfunction, including interstitial lung disease (ILD). The most common telomere-related mutation-associated ILD is idiopathic pulmonary fibrosis (IPF). Read More

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December 2018

The Tyrosine Kinase Inhibitor TAS-115 Attenuates Bleomycin-Induced Lung Fibrosis in Mice.

Am J Respir Cell Mol Biol 2018 Dec 12. Epub 2018 Dec 12.

University of Tokushima Graduate School, Respiratory Medicine and Rheumatology, Tokushima, Japan ;

The signaling pathways of growth factors including platelet-derived growth factor (PDGF) can be considered specific targets for overcoming the poor prognosis of idiopathic pulmonary fibrosis (IPF). Nintedanib, the recently approved multiple kinase inhibitor, has shown promising anti-fibrotic effects in IPF patients; however, its efficacy is still limited, and in some cases, treatment discontinuation is necessary due to toxicities such as gastrointestinal disorders. Therefore, more effective agents with less toxicity are still needed. Read More

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December 2018

Mechanical Augmentation With Absorbable Alginate Sheet Enhances Healing of the Rotator Cuff.

Orthopedics 2018 Dec 11:1-7. Epub 2018 Dec 11.

For anatomical restoration of a repaired rotator cuff, mechanical augmentation of the repaired structure is essential. Using histological and biomechanical evaluation in a rat model, the authors sought to determine the efficacy of an absorbable alginate sheet at the supraspinatus tendon-to-bone repair site for healing of the rotator cuff tear. Forty adult (12 weeks old) male Sprague- Dawley wild-type rats were used in this study. Read More

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December 2018

Revision of Failed Resurfacing Hemiarthroplasty: Midterm Results, Survival, and Group Comparison.

Orthopedics 2018 Dec 11:1-7. Epub 2018 Dec 11.

Shoulder arthroplasty is a valuable option for treating glenohumeral osteoarthritis. Revision surgery for a failed shoulder arthroplasty is associated with difficult procedures, complications, and worse outcomes. Compared with a total joint arthroplasty, a resurfacing prosthesis has the supposed advantages of limited perioperative complications and little bone loss during revision. Read More

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December 2018
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[High hyperdiploid acute lymphoblastic leukemia is a highly curable subtype of childhood leukemia].

Magy Onkol 2018 Dec 30;62(4):214-221. Epub 2018 Oct 30.

Patológiai Intézet, PTE Klinikai Központ, Pécs, Hungary.

Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children. In Hungary 60-70 new cases are diagnosed annually. The survival rate is 85-90% in developed countries with current treatment protocols. Read More

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December 2018

Improved multilineage human hematopoietic reconstitution and function in NSGS mice.

PLoS One 2018 12;13(12):e0209034. Epub 2018 Dec 12.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

Genetic manipulation of NOD/SCID (NS) mice has yielded numerous sub-strains with specific traits useful for the study of human hematopoietic xenografts, each with unique characteristics. Here, we have compared the engraftment and output of umbilical cord blood (UCB) CD34+ cells in four immune-deficient strains: NS, NS with additional IL2RG knockout (NSG), NS with transgenic expression of human myeloid promoting cytokines SCF, GM-CSF, and IL-3 (NSS), and NS with both IL2RG knockout and transgenic cytokine expression (NSGS). Overall engraftment of human hematopoietic cells was highest in the IL2RG knockout strains (NSG and NSGS), while myeloid cell output was notably enhanced in the two strains with transgenic cytokine expression (NSS and NSGS). Read More

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December 2018

Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFI16 in cd44-/- tumor cells, MEFs and macrophages.

PLoS One 2018 12;13(12):e0207358. Epub 2018 Dec 12.

Leibniz Institute on Aging, Fritz Lipmann Institute (FLI), Jena, Germany.

The adhesion molecule and co-receptor of receptor tyrosine kinases, CD44, is expressed in all cells of the immune system, but also in numerous non-immune cells. CD44 plays roles in the cellular response to different pathogens. The molecular actions of CD44 during these processes are by and large still unknown. Read More

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December 2018

Low 25-hydroxyvitamin D levels are more prevalent in Canadians of South Asian than European ancestry inhabiting the National Capital Region of Canada.

PLoS One 2018 12;13(12):e0207429. Epub 2018 Dec 12.

Bureau of Nutritional Sciences, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada.

The US Institute of Medicine defined serum 25-hydroxyvitamin D (25OHD) cut point values of 30 nmol/L and 40 nmol/L were used to assess the vitamin D status of South Asian and European Canadians of self-identified ancestry living in the National Capital Region of Canada. Serum 25OHD values were measured in the spring and fall of 2012 to represent status during the winter and summer months, respectively. A total of 1238 measurements were obtained from 669 participants (49% South Asian ancestry): some participants were measured only once (spring or fall). Read More

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December 2018
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Loading of the hip and knee joints during whole body vibration training.

PLoS One 2018 12;13(12):e0207014. Epub 2018 Dec 12.

Julius Wolff Institute, Charité - Universitätsmedizin Berlin, Berlin, Germany.

During whole body vibrations, the total contact force in knee and hip joints consists of a static component plus the vibration-induced dynamic component. In two different cohorts, these forces were measured with instrumented joint implants at different vibration frequencies and amplitudes. For three standing positions on two platforms, the dynamic forces were compared to the static forces, and the total forces were related to the peak forces during walking. Read More

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December 2018

PCSeg: Color model driven probabilistic multiphase level set based tool for plasma cell segmentation in multiple myeloma.

PLoS One 2018 12;13(12):e0207908. Epub 2018 Dec 12.

SBILab, Department of ECE, Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi), New Delhi, India.

Plasma cell segmentation is the first stage of a computer assisted automated diagnostic tool for multiple myeloma (MM). Owing to large variability in biological cell types, a method for one cell type cannot be applied directly on the other cell types. In this paper, we present PCSeg Tool for plasma cell segmentation from microscopic medical images. Read More

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December 2018

Pre-operative Assessment of Bone Quality in Spine Deformity Surgery: Correlation with Clinical Practice and Published Recommendations.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, NYU Langone Health, New York, NY.

Study Design: Retrospective cohort study.

Objective: The goals of this study were to (1) evaluate pre-operative bone quality assessment and intervention practice over time and (2) review the current evidence for bone evaluation in spine fusion surgery.

Summary Of Background Data: Deformity spine surgery has demonstrated improved quality of life in patients however its cost has made it controversial. Read More

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December 2018

Long-term Outcomes of Ossiculoplasty With and Without an Intact Malleus.

Otol Neurotol 2019 Jan;40(1):73-78

Division of Otology and Neurotology, Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Objective: To compare long-term hearing outcomes following ossiculoplasty with cartilage tympanoplasty with (M) and without (M) the malleus present.

Study Design: Retrospective chart review.

Setting: Tertiary referral center. Read More

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January 2019

Biomechanics of Femoral Neck Fractures and Implications for Fixation.

J Orthop Trauma 2019 Jan;33 Suppl 1:S27-S32

*Institute for Biomechanics, BG Unfallklinik Murnau, Murnau, Germany; and †Institute for Biomechanics, Paracelsus Medical University Salzburg, Salzburg, Austria.

Fractures of the femoral neck can occur in young healthy individuals due to high loads occurring during motor vehicle accidents, impacts, or falls. Failure forces are lower if impacts occur sideways onto the greater trochanter as compared with vertical loading of the hip. Bone density, bone geometry, and thickness of cortical bone at the femoral neck contribute to its mechanical strength. Read More

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January 2019

Total Knee Arthroplasty in Patients with Familial Patellar Absentia Syndrome: A 40-Year Update: A Case Report.

JBJS Case Connect 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, Northwell Health, Huntington Hospital, Huntington, New York.

Case: Isolated patella absentia is an extremely rare phenomenon, with only a few published cases and even fewer follow-up reports. Nearly 40 years after the initial presentation of 2 brothers with bilateral congenital absence of the patella and the publication of a case report, we report the clinical and radiographic findings of their subsequent tibiofemoral osteoarthritis, which was treated with bilateral total knee arthroplasty.

Conclusion: Understanding the biomechanical complications associated with congenital absence of the patella as it relates to a stable knee is vital; in the case of degenerative changes, total knee arthroplasty appears to provide a long-term solution for these patients. Read More

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December 2018

Standards of Care for Hypoparathyroidism in Adults.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

B Clarke, Medicine, Mayo Clinic School of Medicine, Rochester, MN, USA, Rochester, United States.

Purpose: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords "hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy". Only English language papers involving humans were included. Read More

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December 2018

Ultraviolet functionalization improved bone integration on titanium surfaces by fluorescent analysis in rabbits calvarium.

J Oral Implantol 2018 Dec 12. Epub 2018 Dec 12.

5 Stomatological Hospital, Southern Medical University, Guangzhou, China.

This study evaluated the effect of ultraviolet functionalization (UV) on bone integration ability in rabbit model, using epifluorescence microscopy. Each of twelve rabbits (n=6) received randomly four titanium domes prepared with or without ultraviolet for 48 hours (UVC,λ= 250 ± 20 nm; Philips, Tokyo, Japan): (1) turned surface (T), (2) turned surface with UV(T-UV), (3) sandblasted (120 μm aluminum oxide) and etched by 18% hydrochloric acid and 49% sulphuric acid at 60°C for 30 min (SLA) and (4) SLA surface with UV(SLA-UV). Fluorochrome bone labels were marked by oxytetracycline at 25 mg/kg on 13th days and 14th days and calcein at 5 mg/kg on 3th days and 4th days before euthanization. Read More

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December 2018

Is anterior guidance a key factor on planning implant treatment for free-end missing in the posterior mandible?

J Oral Implantol 2018 Dec 12. Epub 2018 Dec 12.

1 Kyushu Dental University Department of Oral Reconstruction and Rehabilitation Kyushu Dental University.

To perform safe implant treatment, the anatomical structure and bone quality at implant placement sites are evaluated based on a patient's CT data, but there is no definite method to determine placement sites and the appropriate number of implants. The objective of this study was to investigate the influence of the number and arrangement of implants on the stress distribution in 3-unit posterior fixed partial dentures for the posterior mandible by mechanical analysis using the finite element method. Three-dimensional finite element analysis models were constructed from the CT data of a patient with missing mandibular teeth (Nos. Read More

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December 2018

Energy-Degeneracy-Driven Covalency in Actinide Bonding.

J Am Chem Soc 2018 Dec 12. Epub 2018 Dec 12.

Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.

Evaluating the nature of chemical bonding for actinide elements represents one of the most important and long-standing problems in actinide science. We directly address this challenge and contribute a Cl K-edge X-ray absorption spectroscopy and relativistic density functional theory study that quantitatively evaluates An-Cl covalency in AnCl (An = Th, U, Np, Pu). The results showed significant mixing between Cl 3p- and An 5f- and 6d-orbitals (t*/t* and t*/e *), with the 6d-orbitals showing more pronounced covalent bonding than the 5f-orbitals. Read More

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December 2018

Screening, prevention and management of osteoporosis among Canadian adults.

Health Promot Chronic Dis Prev Can 2018 Dec;38(12):445-454

Public Health Agency of Canada, Ottawa, Ontario, Canada.

Introduction: This study provides a benchmark for the nationwide use of osteoporosis screening, prevention and management strategies among Canadians aged 40 years and older (40+) using data collected one year prior to the release of Osteoporosis Canada's latest (2010) clinical practice guidelines.

Methods: Data are from the 2009 Canadian Community Health Survey-Osteoporosis Rapid Response Component. The study sample (n = 5704) was divided into four risk subgroups: (1) osteoporosis diagnosis and major fracture; (2) osteoporosis diagnosis only; (3) major fracture only; or (4) neither osteoporosis diagnosis nor major fracture. Read More

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December 2018

Activin A in Mammalian Physiology.

Physiol Rev 2019 Jan;99(1):739-780

Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.

Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More

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January 2019

The Activity of Peptides of the Calcitonin Family in Bone.

Physiol Rev 2019 Jan;99(1):781-805

Department of Medicine, University of Auckland , Auckland , New Zealand.

Calcitonin was discovered over 50 yr ago as a new hormone that rapidly lowers circulating calcium levels. This effect is caused by the inhibition of calcium efflux from bone, as calcitonin is a potent inhibitor of bone resorption. Calcitonin has been in clinical use for conditions of accelerated bone turnover, including Paget's disease and osteoporosis; although in recent years, with the development of drugs that are more potent inhibitors of bone resorption, its use has declined. Read More

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January 2019

Acutely infected teeth: to extract or not to extract?

Braz Oral Res 2018 Dec 6;32:e124. Epub 2018 Dec 6.

Necmettin Erbakan University, Faculty of Dentistry, Oral and Maxillofacial Surgery Department, Konya, Turkey.

Not only laymen but also dentists generally believe that extraction of acutely infected teeth should be avoided until the infection subdues by using systemic antibiotics. The aim of this study was to compare perioperative complications in routine extractions of acutely infected teeth with extractions of asymptomatic teeth. This prospective study was performed with 82 patients. Read More

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December 2018

VITAMIN D DEFICIENCY AND PARATOHOMMONIUM INCREASE IN LATE POSTOPERATIVE GASTRIC BYPASS IN ROUX-EN-Y.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1407. Epub 2018 Dec 6.

Lane Clinic, Campinas, SP, Brazil.

Background : Roux-en-Y gastric bypass patients can experience changes in calcium metabolism and hyperparathyroidism secondary to vitamin D deficiency.

Aim : To evaluate nutritional deficiencies related to the calcium metabolism of patients undergoing gastric bypass with a 10-year follow-up.

Method : This is a longitudinal retrospective study of patients submitted to Roux-en-Y gastric bypass at a multidisciplinary clinic located in the Brazilian southeast region. Read More

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December 2018

Severe hypercalcemia: A rare and unusual presentation of acute lymphoblastic leukemia.

J Cancer Res Ther 2018 Dec;14(Supplement):S1244-S1246

Division of Pediatric Hemato Oncology, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.

Hypercalcemia is a rare and unusual complication of childhood malignancies. Acute lymphoblastic leukemia (ALL) presenting with hypercalcemia and lytic bone lesions is very rare in children. Here, we report a case of a 4-year-old girl with ALL who presented with severe hypercalcemia and radiological evidence of osteolytic lesions. Read More

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December 2018
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Endostar continuous intravenous infusion combined with S-1 and oxaliplatin chemotherapy could be effective in treating liver metastasis from gastric cancer.

J Cancer Res Ther 2018 Dec;14(Supplement):S1148-S1151

Department of Oncology. Dongying People's Hospital, Dongying, Shandong, China.

Objective: Endostar is a new vascular epithelial inhibitor, which is reported to be effective in treating liver metastasis from gastric cancer. However, the optimal therapeutic regimen of Endostar remains unclear. Thus, our study aimed to examine the efficacy and safety of Endostar continuous intravenous infusion combined with S-1 and oxaliplatin (SOX) chemotherapy in treating such patients. Read More

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December 2018

An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis.

Cytokine 2019 Jan 28;113:1-12. Epub 2018 Jun 28.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address:

Osteoarthritis is the most prevalent form of aging-related joint diseases, and its etiology is still not fully understood. Obesity has been recognized as one of the most significant and potentially preventable risk factors for osteoarthritis. Beyond mechanical loading, adipokines, including leptin, visfatin, adiponectin, resistin and others, are demonstrated to have metabolic implications in the pathogenesis and progression in obesity-induced osteoarthritis by modulating the pro/anti-inflammatory and anabolic/catabolic balance, apoptosis, matrix remodeling and subchondral bone ossification. Read More

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January 2019

Utility of early active motion for flexor tendon repair with concomitant injuries: A multivariate analysis.

Injury 2018 Dec 22;49(12):2248-2251. Epub 2018 Oct 22.

Department of Orthopaedic Surgery, Nagoya Ekisaikai Hospital, 4-66 Shonen-Cho, Nakagawa-Ku, Nagoya, 454-8502, Japan.

Introduction: Flexor tendon injury often occurs with concomitant injuries such as fracture, vascular injury, and extensor tendon injury. These injuries are repaired independently, without a comprehensive strategy. We aimed to identify the effect of concomitant injuries and treatment choice on the outcome of flexor tendon repair. Read More

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December 2018

Loss of the Nodal modulator Nomo results in chondrodysplasia in zebrafish.

Curr Mol Med 2018 Dec 11. Epub 2018 Dec 11.

The Center for Heart Development, State Key Lab of Development Biology, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, Hunan. China.

Background: Transforming growth factor-β (TGF-β)/nodal signaling is involved in early embryonic patterning in vertebrates. Nodal modulator (Nomo, also called pM5) is a negative regulator of nodal signaling. Currently, the role of nomo gene in cartilage development in vertebrates remains unknown. Read More

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December 2018

Suppressive Effects of the Standardized Extract of Phyllanthus amarus on Type II collagen-induced Rheumatoid Arthritis in Sprague Dawley Rats.

Curr Pharm Biotechnol 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Medicine,University of Tabuk, Tabuk 71491. Saudi Arabia.

Background: Standardized extract of Phyllanthus amarus has been shown to possess inhibitory effects on cellular and humoral immune responses in Wistar-Kyoto rats and Balb/c mice.

Objective: In the present study, the standardized extract of P. amarus was investigated for its suppressive effects on type II collagen-induced rheumatoid arthritis (TCIA) in Sprague Dawley rats. Read More

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December 2018

Survival Impact of Locoregional Treatment of the Primary Tumor in De Novo Metastatic Breast Cancers in a Large Multicentric Cohort Study: A Propensity Score-Matched Analysis.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical Oncology, Claudius Regaud Institute, IUCT-Oncopole, Toulouse Cedex 09, France.

Introduction: Improvement in overall survival (OS) by locoregional treatment (LRT) of the primary tumor in de novo metastatic breast cancer (MBC) patients remains controversial.

Objective: The aim of our study was to evaluate the impact of LRT on OS in a large retrospective cohort of de novo MBC patients, with regard to immunohistochemical characteristics and pattern of metastatic dissemination.

Methods: We conducted a multicentric retrospective study of patients diagnosed with de novo MBC selected from the French Epidemiological Strategy and Medical Economics MBC database (NCT03275311) between 2008 and 2014. Read More

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December 2018

Laterally Extended Pelvic Resection for Gynaecological Malignancies: A Multicentric Experience with Out-of-the-Box Surgery.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Gynaecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague, General University Hospital in Prague, Prague, Czech Republic.

Purpose: To evaluate morbidity and oncological outcome in a multicentre series of women with gynaecological malignancies infiltrating pelvic side wall (PSW) that received laterally extended pelvic resection (LEPR).

Methods: Patients operated between 2007 and 2017 at three institutions were included. LEPR was defined as an en bloc lateral resection of a pelvic tumour involving sidewall muscle, and/or bone, and/or major nerve, and/or major vascular structure. Read More

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December 2018

Nucleic Acid Extraction from Human Biological Samples.

Methods Mol Biol 2019 ;1897:359-383

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Nucleic acid isolation is often the starting point for all downstream experiments in biomedical research. It is therefore the most crucial step in any molecular technique. DNA and RNA extraction follow protocols with standardized reagents, many of which are available in quality-controlled commercial kits. Read More

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January 2019

Pretreatment-Etidronate Alleviates CoCl Induced-SH-SY5Y Cell Apoptosis via Decreased HIF-1α and TRPC5 Channel Proteins.

Neurochem Res 2018 Dec 11. Epub 2018 Dec 11.

College of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin, 300071, China.

Chronic hypoxic damage is one of the most common pathogenic factors that can cause neurodegenerative disorder in most cases. Etidronate (Eti) is one of the best-known earlier-generations of bisphosphonate derivatives for the treatment of bone-loss related diseases. Building on the preceding study of our laboratory, we found that Eti showed neuroprotective effects against 2-vessel occlusion induced vascular dementia (VD) in rats. Read More

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December 2018

Diastolic dysfunction in rheumatoid arthritis patients with low disease activity.

Clin Rheumatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Ul. Jaczewskiego 8, 20-950, Lublin, Poland.

Introduction/objectives: Patients with rheumatoid arthritis (RA) are at increased risk for congestive heart failure (CHF) and left ventricular diastolic dysfunction (LVDD), as compared to the general population. High disease activity is to be associated with higher incidence of cardiovascular disease (CVD), CHF, and mortality in RA patients. LVDD is not anticipated in RA patients without CVD symptoms and may be underdiagnosed especially in those with low disease activity. Read More

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December 2018

Isolation and Identification of Murine Bone Marrow-Derived Macrophages and Osteomacs from Neonatal and Adult Mice.

Methods Mol Biol 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Hematopoietic stem cells (HSCs) are regulated by multiple components of the hematopoietic niche, including bone marrow-derived macrophages and osteomacs. However, both macrophages and osteomacs are phenotypically similar. Thus, specific phenotypic markers are required to differentially identify the effects of osteomacs and bone marrow macrophages on different physiological processes, including hematopoiesis and bone remodeling. Read More

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December 2018

Large opening gaps, unstable hinge fractures, and osteotomy line below the safe zone cause delayed bone healing after open-wedge high tibial osteotomy.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Hokuriku Hospital, 2-13-43 Izumigaoka, Kanazawa, 921-8035, Japan.

Purpose: To evaluate bone formation in the osteotomy gap after open-wedge high tibial osteotomy (OWHTO), including after plate removal, and to investigate risk factors for delayed bone healing.

Methods: Ninety-three patients (102 knees) who underwent OWHTO without bone grafting were enrolled. The osteotomy gap was divided into the lateral hinge and the four zones on anteroposterior radiographs, and we defined the zone in which trabecular bone continuity could be observed as gap filling. Read More

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December 2018

Tourniquet application does not affect the periprosthetic bone cement penetration in total knee arthroplasty.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedics and Trauma Surgery, University Medical Center Mannheim of University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Purpose: Poor scientific evidence exists on the issue of tourniquet application during total knee arthroplasty (TKA). It has been suggested that tourniquet application might improve interdigitation of the cement into the periprosthetic bones due to relatively dry surgical field. The hypothesis of the present study was that tourniquet use did not affect the periprosthetic bone cement penetration. Read More

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December 2018

Mitochondrial health and muscle plasticity after spinal cord injury.

Eur J Appl Physiol 2018 Dec 11. Epub 2018 Dec 11.

James J. Peters VA Medical Center, Bronx, NY, USA.

Mitochondria are responsible for aerobic respiration and large-scale ATP production in almost all cells of the body. Their function is decreased in many neurodegenerative and cardiovascular disease states, in metabolic disorders such as type II diabetes and obesity, and as a normal component of aging. Disuse of skeletal muscle from immobilization or unloading triggers alterations of mitochondrial density and activity. Read More

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December 2018

Full-length transcriptome and microRNA sequencing reveal the specific gene-regulation network of velvet antler in sika deer with extremely different velvet antler weight.

Mol Genet Genomics 2018 Dec 11. Epub 2018 Dec 11.

State Key Laboratory for Molecular Biology of Special Economic Animals, Key Laboratory of Genetics, Breeding and Reproduction of Special Economic Animals, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China.

Velvet antler displays the fastest and most robust tissue proliferation in the animal world, it is a model for a complete organ development/regeneration, and alternative medicine, tonic made from velvet antler, was beneficial for human. The weight of velvet antler had high biomedical and economic value, but the related regulation mechanisms controlling velvet antler weight remain unclear. In this study, extremely heavy and light velvet antler groups were selected from a sika deer population of 100 individuals with extreme velvet antler weight. Read More

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December 2018

Whole-body low-dose CT recognizes two distinct patterns of lytic lesions in multiple myeloma patients with different disease metabolism at PET/MRI.

Ann Hematol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Institute of Radiology, Padua University School of Medicine, Padua, Italy.

We evaluated differences in density and F-FDG PET/MRI features of lytic bone lesions (LBLs) identified by whole-body low-dose CT (WB-LDCT) in patients affected by newly diagnosed multiple myeloma (MM). In 18 MM patients, 135 unequivocal LBLs identified by WB-LDCT were characterized for inner density (negative or positive Hounsfield unit (HU)), where negative density (HU < 0) characterizes normal yellow marrow whereas positive HU correlates with tissue-like infiltrative pattern. The same LBLs were analyzed by F-FDG PET/DWI-MRI, registering DWI signal with ADC and SUV max values. Read More

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December 2018

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies.

Osteoporos Int 2018 Dec 12. Epub 2018 Dec 12.

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing St., Taipei, 110, Taiwan.

We performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1. Read More

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December 2018
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