Search Our Scientific Publications & Authors

J Oral Biol Craniofac Res 2020 Apr-Jun;10(2):141-145. Epub 2020 Apr 15.

Manchester, CT, USA.

Aim: To observe clinically and radiographically (CBCT), the extent of bone resorption in extraction socket without the use of bone graft substitutes and delayed implant placement.

Material And Methods: 50 compliant patients were selected for study. All the patients who were advised extraction were followed up for entire duration of the treatment, at 5th week CBCT showed horizontal and vertical bone loss. Read More

Mater Sci Eng C Mater Biol Appl 2020 Aug 24;113:110981. Epub 2020 Apr 24.

Department Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, United States of America. Electronic address:

Bone tissue engineering aims to alleviate the shortage of available autograft material and the biological/mechanical incompatibility of allografts through fabrication of bioactive synthetic bone graft substitutes. However, these substitute grafting materials have insufficient biological potency that limits their clinical efficacy in regenerating large defects. Extracellular matrix, a natural tissue scaffold laden with biochemical and structural cues regulating cell adhesion and tissue morphogenesis, may be a versatile supplement that can extend its biological functionality to synthetic grafts. Read More

Biomater Sci 2014 Feb 10;2(2):233-241. Epub 2013 Oct 10.

School of Materials, The University of Manchester, Grosvenor Street, Manchester, M1 7HS, UK.

We describe a novel polymer containing phosphonic acid moieties which has been shown to increase the osteoblast response and decrease osteoclast activity. A 3D scaffold comprising of poly(ε-caprolactone) (PCL) functionalised with poly(vinyl phosphonic acid-co-acrylic acid) (PVPA-AA) was fabricated using electrospinning. PVPA-AA is hypothesised to mimic the action of bisphosphonates, a group of drugs used to treat osteoporosis, and likely to affect bone turnover by increasing the activity of osteoblasts and reducing osteoclast activity. Read More

Ann Anat 2020 May 4;231:151524. Epub 2020 May 4.

Department for Periodontology, Faculty of Health, Witten/Herdecke University, Witten, Germany.

Objectives: To explore whether placement of a soft cortical membrane can restore and regenerate the original alveolar ridge contour in deficient sockets.

Materials And Methods: One Beagle dog was used in this proof-of-principle evaluation. In a first intervention, a standardized buccal dehiscence defect was artificially created at the distal roots of the 3rd and 4th mandibular premolars. Read More

In Vivo 2020 May-Jun;34(3):1053-1061

Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Aim: The aim of this in vivo study was to evaluate the utility of bone graft gel containing hydroxyapatite nanoparticles in promoting bone regeneration in a mouse model of vertical bone augmentation.

Materials And Methods: Gel implants with high and low viscosity were compared for their bone regenerating ability. Bone formation at 12 weeks and material reactions were observed radiographically and histologically. Read More

Stem Cells Int 2020 5;2020:1321283. Epub 2020 Apr 5.

Translational Platform for Regenerative Medicine, Mossakowski Medical Research Centre, Polish Academy of Sciences, Poland.

Objective: Bone defects or atrophy may arise as a consequence of injury, inflammation of various etiologies, and neoplastic or traumatic processes or as a result of surgical procedures. Sometimes the regeneration process of bone loss is impaired, significantly slowed down, or does not occur, e.g. Read More

J Biomed Mater Res A 2020 May 30;108(7):1546-1562. Epub 2020 Mar 30.

Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

Bone is a self-engineered structural component of the human body with multifaceted mechanical strength, which provides indomitable support to the effective functioning of the human body. It is indispensable to find a suitable biomaterial for substituting the bone as the bone substitute material requirement is very high due to the rate of bone fracture and infection lead to osteoporosis in human beings increases rapidly. It is not an easy task to design a material with good apatite deposition ability, a faster rate of dissolution, superior resorbability, high mechanical strength, and significant bactericidal activity. Read More

Materials (Basel) 2020 Mar 5;13(5). Epub 2020 Mar 5.

Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.

Background: The histological and histomorphometrical results were evaluated between vital whole and non-vital endodontically treated teeth used as autologous grafts in post-extractive socket preservation procedures.

Methods: Twenty-eight patients (average age 51.79 ± 5. Read More

In Vivo 2020 Mar-Apr;34(2):609-614

Department of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea

Background/aim: Tooth extraction is a common procedure in dental clinics. Tooth extraction can destroy gingiva, alveolar bone, periodontal ligaments and cement. If dental sockets are left as extracted, it will result in loss of teeth, as well as voice and aesthetic problems. Read More

Tissue Eng Part A 2020 Mar 26. Epub 2020 Mar 26.

Northwestern University Department of Orthopaedic Surgery, Chicago, Illinois.

We previously developed a recombinant growth factor-free, three-dimensional (3D)-printed material comprising hydroxyapatite (HA) and demineralized bone matrix (DBM) for bone regeneration. This material has demonstrated the capacity to promote re-mineralization of the DBM particles within the scaffold struts and shows potential to promote successful spine fusion. Here, we investigate the role of geometry and architecture in osteointegration, vascularization, and facilitation of spine fusion in a preclinical model. Read More

Spine (Phila Pa 1976) 2020 Feb 19. Epub 2020 Feb 19.

Department of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Study Design: Patient and observer blinded, multicenter, randomized, intra-patient controlled, non-inferiority trial.

Objective: To determine non-inferiority of a biphasic calcium-phosphate (AttraX® Putty) as a bone graft substitute for autograft in instrumented posterolateral fusion (PLF).

Summary Of Background Data: Spinal fusion with autologous bone graft is a frequently performed surgical treatment. Read More

Acta Biomater 2020 04 8;106:136-144. Epub 2020 Feb 8.

Division of Plastic Surgery and Hand Surgery, University Hospital Zurich, Raemistrasse 100, Zurich 8091, Switzerland. Electronic address:

After skin tissue injury or pathological removal, vascularization timing is paramount in graft survival. As full thickness skin grafts often fail to become perfused over larger surfaces, split-thickness grafts are preferred and can be used together with biomaterials, which themselves are non-angiogenic. One way of promoting vascular ingrowth is to "pre-vascularize" an engineered substitute by introducing endothelial cells (ECs). Read More

Clin Oral Investig 2020 Jan 24. Epub 2020 Jan 24.

Department of Oral Surgery and Central Admittance, University Hospital, Heichrich-Heine-University, Düsseldorf, Germany.

Objective: To assess the influence of biphasic calcium phosphate materials with different surface topographies on bone formation and osseointegration of titanium implants in standardized alveolar ridge defects.

Materials And Methods: Standardized alveolar ridge defects (6 × 6 mm) were created in the mandible of 8 minipigs and filled with three biphasic calcium phosphate materials (BCP1-3, 90% tricalcium phosphate/10% hydroxyapatite) with different surface properties (micro- and macroporosities) as well as a bovine-derived natural bone mineral (NBM) as a control. At 12 weeks, implants were placed into the augmented defects. Read More

J Korean Assoc Oral Maxillofac Surg 2019 Dec 26;45(6):332-342. Epub 2019 Dec 26.

Department of Oral and Maxillofacial Pathology, Sibar Institute of Dental Sciences, Guntur, India.

Objectives: Socket grafting is vital to prevent bone resorption after tooth extraction. Several techniques to prevent resorption have been described, and various bone graft substitutes have been developed and used with varying success. We conducted this pilot study to evaluate the performance of nanohydroxyapatite (nHA) derived from chicken eggshells in socket preservation. Read More

Dent J (Basel) 2020 Jan 9;8(1). Epub 2020 Jan 9.

1st Department of Pathology, Medical School, University of Athens, 75 M. Assias Street, 11527 Athens, Greece.

Regeneration of large jaw bone defects still remains a clinical challenge. To avoid incomplete bone repair, bone grafts have been advocated to support the healing process. This study comparatively evaluated new bone formation among a synthetic graft substitute, a human bone derivative, and a bovine xenograft. Read More

Biomed Res Int 2019 14;2019:8105351. Epub 2019 Dec 14.

Austrian Cluster for Tissue Regeneration, Vienna, Austria.

Background: The high resorption rate of autogenous bone is a well-documented phenomenon that can lead to insufficient bone quality and quantity in an augmented area. Nonresorbable bone substitutes might perform better than autogenous bone in certain applications if they are able to provide adequate bone formation and graft osseointegration.

Purpose: The aim of this study was to compare the osseous regeneration and graft integration in standardized defects in the rabbit femur treated either with porous titanium granules or autogenous osseous graft. Read More

Curr Eye Res 2020 Mar 10;45(3):253-264. Epub 2020 Jan 10.

Department of Ophthalmology, University Hospital Duesseldorf, Duesseldorf, Germany.

When an eye has become irreversibly blind or painful it is removed by enucleation or evisceration. The resulting anophthalmic socket usually receives a volume replacing implant and is subsequently fitted with a prosthetic shell for adequate cosmesis. Trauma, tumour or immunological pathomechanisms can induce loss of bone, orbital soft tissue volume, and conjunctival contraction or implant exposure, which result in difficult or impossible prosthesis wear. Read More

Eur Spine J 2020 Jun 23;29(6):1261-1276. Epub 2019 Dec 23.

Department of Orthopedic Oncology, Tianjin Hospital, No. 406, Jiefang Southern Road, Hexi District, Tianjin, 300211, China.

Purpose: A variety of alternative grafts to autologous iliac crest bone (ICBG) have been developed for lumbar spondylodesis, due to frequent complications following ICBG harvest. The optimal alternative graft to ICBG, however, remains elusive till now. The purpose of this study was to compare the efficacy and safety of fusion materials in lumbar degeneration diseases and to provide a ranking spectrum of the grafts. Read More

Materials (Basel) 2019 Dec 5;12(24). Epub 2019 Dec 5.

Pius Hospital, Universitätsklinik für Orthopädie und Unfallchirurgie, 26121 Oldenburg, Germany.

Bacterial bone infections after revision surgeries and diseases, like osteomyelitis, are still a challenge with regard to surgical treatments. Local bone infections were treated with antibiotics directly or by controlled drug-releasing scaffolds, like polymethylmethacrylate (PMMA) spheres, which have to be removed at a later stage, but there is a risk of a bacterial contamination during the removement. Therefore, biomaterials loaded with antibiotics for controlled release could be the method of choice: The biomaterials degrade during the drug release, therefore, there is no need for a second surgery to remove the drug eluting agent. Read More

Biomed Res Int 2019 31;2019:1614024. Epub 2019 Oct 31.

Department of Prosthodontics, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.

The purpose of the present study was to investigate the effect of local hydroxyapatite (HA) combined with extracted sea cucumber () collagen as a promising bone graft substitute on bone remodeling. Fourier-transform infrared spectroscopy, X-ray diffractometry, transmission electron microscopy, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and Sprague-Dawley rat model were used to characterize the microstructure, cytotoxicity, and bone-healing properties of the investigated biocomposite material. Analytical results found that the hydrothermal reaction-synthesized local HA had a hexagonal close-packed structure. Read More

Materials (Basel) 2019 Dec 2;12(23). Epub 2019 Dec 2.

Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

The utility of carbonate apatite (COAp) as a bone substitute has been demonstrated. The feasibility of fabricating macroporous COAp was evaluated through a two-step dissolution-precipitation reaction using gypsum as the precursor and spherical phenol resin as the porogen. Porogen-containing gypsum was heated to burn out the porogen and to fabricate macroporous structures. Read More

Tissue Eng Part C Methods 2020 Jan;26(1):56-65

Department of Trauma and Orthopedic Surgery, Experimental Trauma Surgery, University Medical Center Schleswig-Holstein, Kiel, Germany.

The increased incidence of bone defects, especially in cases of comminuted fractures or bone tumor resections demands suitable bone grafts and substitutes. The aim of this study was to establish an bone defect model to evaluate new bone substitutes and associated repair processes under controlled conditions. Femoral heads derived from patients undergoing total hip replacement were cut into cylinders (20 mm diameter, 7 mm height). Read More

Tissue Eng Part B Rev 2020 Feb 6;26(1):64-78. Epub 2020 Jan 6.

Department of Materials Science and Engineering, East China University of Science and Technology, Shanghai, P.R. China.

The bone repair and substitute have been developed for decades with the bone defect repair applied successfully in clinical. However, implant complications may occur in more challenging situations, bone cell senescence and osteoporosis (OP). Due to certain microenvironment conditions, including hormonal, nutritional, and aging factors, the bone cell responses are regulated to alteration and end into cell senescence and OP. Read More

J Contemp Dent Pract 2019 Aug 1;20(8):987-993. Epub 2019 Aug 1.

Department of Periodontics, Ar Rass College of Dentistry, University of Qassim, Kingdom of Saudi Arabia.

Since a long time, the preservation of the socket is emphasized for various reasons. Many studies have suggested the ridge preservation through socket grafting using various bone graft substitute materials (GSMs). But none of the studies suggested the material of choice for the grafting. Read More

Z Orthop Unfall 2019 Dec 3;157(6):715-728. Epub 2019 Dec 3.

Autologous cancellous bone grafting remains the gold standard in the treatment of bone defects as it meets all requirements (osteoinduction, osteoconduction, osteointegration). Over time, bone replacement materials will become increasingly important in orthopedics and trauma surgery. The main representatives of bone replacement materials are calcium phosphates (ceramics and cements). Read More

J Rural Med 2019 Nov 20;14(2):211-215. Epub 2019 Nov 20.

Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Japan.

To treat vertebral fractures with posterior wall injury in the elderly, vertebral bone grafting is generally performed through a posterior transpedicular approach, combined with pedicle screw fixation. An autologous bone is ideal to treat this disorder. However, harvesting autologous bones from the elderly with osteoporosis is limited by the amount and quality of available autologous bone. Read More

J Funct Biomater 2019 Nov 22;10(4). Epub 2019 Nov 22.

Industrie Biomediche Insubri SA, 6805 Mezzovico-Vira, Switzerland.

Total hip arthroplasty (THA) is a surgical procedure for the replacement of hip joints with artificial prostheses. Several approaches are currently employed in the treatment of this kind of defect. Overall, the most common method involves using a quite invasive metallic support (a Burch-Schneider ring). Read More

Int J Spine Surg 2019 Oct 31;13(5):437-458. Epub 2019 Oct 31.

Cedars-Sinai Medical Center, Los Angeles, California.

Background: Insufficient data exist on bone graft substitute materials efficacy; two thirds lack any clinical data.1,2 This prospective animal study identified efficacy differences among commercially available materials of several classes.

Methods: Historically validated muscle pouch osteoinduction study (OIS) and posterolateral fusion (PLF) were performed in an athymic rat model. Read More

Clin Implant Dent Relat Res 2019 Dec 19;21(6):1241-1252. Epub 2019 Nov 19.

Oral & Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Purpose: The present study was conducted to evaluate the amount of bone height gain, density values, and implant stability after maxillary sinus floor elevation using graftless tenting technique or the use of Hydroxyapatite Nanoparticles bone substitute for augmentation with simultaneous implant placement.

Materials And Methods: A total of 20 sinuses with a residual alveolar bone height ranging from 4-6 mm were divided into two groups and underwent sinus augmentation using nano hydroxyapatite bone substitute material and the graftless tenting technique with simultaneous implant placement. Computed tomography CT scans and ISQ measurements were conducted to evaluate bone quality, quantity, and implant stability. Read More

J Orthop Res 2020 Mar 25;38(3):536-544. Epub 2019 Nov 25.

Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts.

Neither allograft nor commercially available bone graft substitutes provide the same quality of bone healing as autograft. Incorporation of bioactive molecules like parathyroid hormone (PTH) within bone graft substitute materials may provide similar, if not better treatment options to grafting. The goal of this work was to develop a biomaterial system for the local delivery of PTH to large bone defects for promoting bone regeneration. Read More

Br J Oral Maxillofac Surg 2019 12 29;57(10):1131-1136. Epub 2019 Oct 29.

Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden.

Our aim was to investigate the possible impact of contamination with saliva on osseointegration during placement of implants with simultaneous bone augmentation. Six hemispheric shape bone defects (8mm in diameter×4mm deep) were prepared in each iliac bone of six sheep. A dental implant (2. Read More

Materials (Basel) 2019 Oct 2;12(19). Epub 2019 Oct 2.

Department of Materials Test Engineering (WPT), TU Dortmund University, Dortmund 44227, Germany.

The present publication reports the purification effort of two natural bone blocks, that is, an allogeneic bone block (maxgraft, botiss biomaterials GmbH, Zossen, Germany) and a xenogeneic block (SMARTBONE, IBI S.A., Mezzovico-Vira, Switzerland) in addition to previously published results based on histology. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Sep;54(9):623-627

Department of Oral Implantology, Stomatological Hospital of Chongqing Medical University & Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences & Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401120, China.

To preliminarily evaluate the clinical effect of the three-dimensional (3D) printing individualized titanium mesh combined with guided bone regeneration technology for repairing alveolar bone defects. Six patients with alveolar bone defects (4 males and 2 females, aged 18-27 years, mean 23.3 years) were selected from the Department of Oral Implantology, Stomatological Hospital of Chongqing Medical University from January to June 2018. Read More

J Indian Soc Periodontol 2019 Sep-Oct;23(5):448-460

Department of Periodontology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India.

Background: Implant site development can be effective in minimizing postextraction alveolar ridge resorption in the esthetic region. Microsurgical approach has demonstrated substantial improvement in soft-tissue architecture.

Aim And Objectives: The aim of the present study was to evaluate and compare the efficacy of microsurgical technique with conventional one for implant site development utilizing biphasic hydroxyapatite/beta-tricalcium phosphate bone graft substitute and collagen membrane. Read More

Tissue Eng Part A 2020 Feb 26;26(3-4):157-166. Epub 2019 Sep 26.

Department of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.

Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) and human demineralized bone matrix (DBM) in a poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds to promote osteointegration in rats, with an end goal of spine fusion without the need for recombinant growth factor. Spine fusion was evaluated by manual palpation, and osteointegration and bone formation within scaffold struts were evaluated by laboratory and synchrotron microcomputed tomography and histology. Read More

JOR Spine 2018 Dec 28;1(4):e1039. Epub 2018 Nov 28.

Kuros Biosciences BV Bilthoven The Netherlands.

As spinal fusions require large volumes of bone graft, different bone graft substitutes are being investigated as alternatives. A subclass of calcium phosphate materials with submicron surface topography has been shown to be a highly effective bone graft substitute. In this work, a commercially available biphasic calcium phosphate (BCP) with submicron surface topography (MagnetOs; Kuros Biosciences BV) was evaluated in an model of instrumented posterolateral fusion. Read More

Med Hypotheses 2019 Nov 19;132:109374. Epub 2019 Aug 19.

Department of Orthopaedics, Beijing Friendship Hospital Affiliated of Capital Medical University, Beijing, China.

Various reasons leading to disruption of blood supply will result in avascular femoral head necrosis. Decompression of lesion area, structural support to subchondral bone, and rebuilding of blood supply system are the keys for a successful hip preserve surgery. Reconstruction of local vascular network is always a huge challenge in clinical. Read More

Knee 2019 Dec 21;26(6):1313-1322. Epub 2019 Aug 21.

TK Orthopedic surgery, Seongnam-si, Gyeonggi-do, Republic of Korea. Electronic address:

Objectives: To investigate the effect of screw length, lateral hinge fracture, and gap filling on stability after medial opening wedge high tibial osteotomy (MOW HTO) using a locking plate.

Methods: Forty tibiae from fresh-frozen cadavers were randomly allocated into five groups. Group A was bicortically fixated, while Group B and Group C were unicortically fixated: 90% and 55% of drilled tunnel length, respectively. Read More

J Craniomaxillofac Surg 2019 Oct 19;47(10):1633-1644. Epub 2019 Jul 19.

FORM-Lab, Frankfurt Oral Regenerative Medicine, Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Germany.

Three-dimensional augmentation in severely atrophic bone and after cancer resection is a challenging clinical indication that is mostly solved using autologous bone transplantation. The development of the digital technique along with the additive manufacturing and three-dimensional (3D) printing opened new avenues for reconstructive oral and maxillofacial surgery. Therefore, patient-specific titanium mesh is a novel means of stabilizing the augmentation region using particulate bone substitute materials (BSMs) combined with autologous bone as a minimally invasive concept. Read More

Eur Cell Mater 2019 08 5;38:35-50. Epub 2019 Aug 5.

Faculty of Medicine and Health Technology, FI-33014 Tampere University, Tampere,

Most synthetic bone grafts are either hard and brittle ceramics or paste-like materials that differ in applicability from the gold standard autologous bone graft, which restricts their widespread use. Therefore, the aim of the study was to develop an elastic, highly porous and biodegradable β-tricalciumphosphate/poly(L-lactide-co-ε-caprolactone) (β-TCP/PLCL) composite for bone applications using supercritical CO2 foaming. Ability to support osteogenic differentiation was tested in human adipose stem cell (hASC) culture for 21 d. Read More

Materials (Basel) 2019 Jul 31;12(15). Epub 2019 Jul 31.

Department of Prosthodontics, Dental Research Institute, Dental and Life Science Institute, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea.

It is important to obtain sufficient bone mass before implant placement on alveolar bone, and synthetic bone such as biphasic calcium phosphate (BCP) has been studied to secure this. This study used a BCP block bone with a specific structure of the three-dimensional (3D) hexahedron channel and coating with recombinant human bone morphogenetic protein-2 (rhBMP-2) impregnated carboxymethyl cellulose (CMC) was used to examine the enhancement of bone regeneration of this biomaterial in rat calvarial defect. After the preparation of critical-size calvarial defects in fifteen rats, defects were divided into three groups and were implanted with the assigned specimen (n = 5): Boneplant (untreated 3D hexahedron channeled BCP block), Boneplant/CMC (3D hexahedron channeled BCP block coated with CMC), and Boneplant/CMC/BMP (3D hexahedron channeled BCP block coated with CMC containing rhBMP-2). Read More

Bull Exp Biol Med 2019 Jul 26;167(3):400-403. Epub 2019 Jul 26.

Faculty of Fundamental Medicine, Moscow, Russia.

A new alloplastic high-permeable material based on tricalcium phosphate with Kelvin architectonics created by stereolithographic 3D-printing was studied in vivo. A monocortical defect of the femur was modeled in rats and the material was implanted into the defect area. In 24 weeks, the animals were euthanized and histological examination of the defect area was performed. Read More

Int J Med Sci 2019 10;16(7):1007-1017. Epub 2019 Jun 10.

Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China.

Bioactive scaffolding materials and efficient osteoinductive factors are key factors for bone tissue engineering. The present study aimed to mimic the natural bone repair process using an osteoinductive bone morphogenetic protein (BMP)-6-loaded nano-hydroxyapatite (nHA)/gelatin (Gel)/gelatin microsphere (GMS) scaffold pre-seeded with bone marrow mesenchymal stem cells (BMMSCs). BMP-6-loaded GMSs were prepared by cross-linking and BMP-6/nHAG/GMS scaffolds were fabricated by a combination of blending and freeze-drying techniques. Read More

J Clin Orthop Trauma 2019 Jul-Aug;10(4):789-791. Epub 2018 Aug 10.

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

Objectives: In recent years, the increase in utilisation of bone substitutes in the reconstruction of bone defects has been fuelled by donor site complications associated with autologous bone harvesting. However the ability of bone substitute to stimulate bone union while maintaining fracture reduction has been a topic of debate. Cerament Bone Void Filler (CBVF) is a novel biphasic and injectable ceramic bone substitute that has high compressive strength and the ability to promote cancellous bone healing. Read More

Int J Oral Maxillofac Surg 2020 Jan 21;49(1):107-120. Epub 2019 Jun 21.

Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy; IRCCS Orthopedic Institute Galeazzi, Milan, Italy.

The purpose of this network meta-analysis was to identify the most effective biomaterials producing higher new bone formation (NBF) and lower residual graft (RG) and connective tissue (CT) following maxillary sinus augmentation (MSA), and to generate a ranking based on their performance. The MEDLINE, Embase, and CENTRAL databases were searched to identify randomized controlled trials (RCTs) published until March 2018, evaluating histomorphometric outcomes after MSA. Predictor variables were autogenous bone (AB), allografts (AG), xenografts (XG), alloplastic bone (AP), AB+XG, AB+AP, AG+XG, XG+AP, and grafts combined with autologous platelet concentrates/recombinant growth factors, mesenchymal stem cells (MSCs), or recombinant bone morphogenetic proteins (BMPs). Read More

Quintessence Int 2019 ;50(7):560-567

Objective: The objective was to assess the outcome of graftless sinus floor augmentation associated with dental implant placement performed with an implant system that has an internal port and screw, combined with the osteotome technique.

Method And Materials: Between 2012 and 2018, 722 titanium-aluminum-vanadium implants (Ti-6Al-4V ELI, diameter 3.75/4. Read More

World Neurosurg 2019 Sep 8;129:298-301. Epub 2019 Jun 8.

Department of Neurosurgery, Ghaem Teaching Hospital, Faculty of Medicine, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Burr hole craniotomy is a daily procedure in neurosurgery. Defects after burr hole craniotomies will not spontaneously heal and can result in skin dents and cosmetic dissatisfaction. We have introduced a self-made, reusable, and adjustable bone plug packer to use in the repair of burr holes via packing of autologous bone dust. Read More

Colloids Surf B Biointerfaces 2019 Sep 23;181:349-359. Epub 2019 May 23.

Institute for Advanced Ceramics, Harbin Institute of Technology, Harbin 150001, China; Key Laboratory of Advanced Structural-Functional Integration Materials & Green Manufacturing Technology, Harbin Institute of Technology, Harbin, 150001, China.

Large segmental bone defect healing remains a great challenge in clinic. Limited by the source of autograft, bone graft substitute tends to be the research focus. In the present study, we propose a strategy by using microarc oxidation (MAO) coated magnesium scaffold as a large segmental bone graft substitute, utilizing its combination of strength, degradability, and controllable corrosion rate. Read More

Clin Orthop Surg 2019 Jun 9;11(2):233-236. Epub 2019 May 9.

Department of Orthopedic Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.

Background: We investigated the clinical outcome in patients whose cavitary bone defects were treated with beta-tricalcium phosphate (β-TCP) after surgical removal of benign tumors.

Methods: Between March 2015 and December 2015, 20 patients who underwent operation for bone tumors were enrolled into this study and prospectively followed up for a median period of 28.1 months. Read More

Clin Oral Implants Res 2019 Sep 19;30(9):849-860. Epub 2019 Jun 19.

School of Dentistry, The University of Queensland, Herston, Queensland, Australia.

Objective: To report biological and technical outcomes of implant-supported restorations placed into previously maxillary sinus floor augmentation using the lateral wall approach (MSA) using anorganic bovine bone mineral (ABBM) + autogenous bone (AB) (control group) or collagen-stabilized ABBM (test group).

Materials And Methods: Single implant was placed 6 months after MSA in 27 control and 26 test patients. Fixed restorations were delivered 12 weeks later and reviewed 12 months after function. Read More