1,005 results match your criteria Bone Graft Substitute Materials


Clinical and radiographic findings without the use of bone substitute materials in extraction sockets and delayed implant placement- A case series.

J Oral Biol Craniofac Res 2020 Apr-Jun;10(2):141-145. Epub 2020 Apr 15.

Manchester, CT, USA.

Aim: To observe clinically and radiographically (CBCT), the extent of bone resorption in extraction socket without the use of bone graft substitutes and delayed implant placement.

Material And Methods: 50 compliant patients were selected for study. All the patients who were advised extraction were followed up for entire duration of the treatment, at 5th week CBCT showed horizontal and vertical bone loss. Read More

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http://dx.doi.org/10.1016/j.jobcr.2020.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254475PMC

Polymeric nanofibrous scaffolds laden with cell-derived extracellular matrix for bone regeneration.

Mater Sci Eng C Mater Biol Appl 2020 Aug 24;113:110981. Epub 2020 Apr 24.

Department Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, United States of America. Electronic address:

Bone tissue engineering aims to alleviate the shortage of available autograft material and the biological/mechanical incompatibility of allografts through fabrication of bioactive synthetic bone graft substitutes. However, these substitute grafting materials have insufficient biological potency that limits their clinical efficacy in regenerating large defects. Extracellular matrix, a natural tissue scaffold laden with biochemical and structural cues regulating cell adhesion and tissue morphogenesis, may be a versatile supplement that can extend its biological functionality to synthetic grafts. Read More

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http://dx.doi.org/10.1016/j.msec.2020.110981DOI Listing

The osteoblast and osteoclast responses to phosphonic acid containing poly(ε-caprolactone) electrospun scaffolds.

Biomater Sci 2014 Feb 10;2(2):233-241. Epub 2013 Oct 10.

School of Materials, The University of Manchester, Grosvenor Street, Manchester, M1 7HS, UK.

We describe a novel polymer containing phosphonic acid moieties which has been shown to increase the osteoblast response and decrease osteoclast activity. A 3D scaffold comprising of poly(ε-caprolactone) (PCL) functionalised with poly(vinyl phosphonic acid-co-acrylic acid) (PVPA-AA) was fabricated using electrospinning. PVPA-AA is hypothesised to mimic the action of bisphosphonates, a group of drugs used to treat osteoporosis, and likely to affect bone turnover by increasing the activity of osteoblasts and reducing osteoclast activity. Read More

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http://dx.doi.org/10.1039/c3bm60188aDOI Listing
February 2014

Ridge preservation of compromised extraction sockets applying a soft cortical membrane: A canine proof-of-principle evaluation.

Ann Anat 2020 May 4;231:151524. Epub 2020 May 4.

Department for Periodontology, Faculty of Health, Witten/Herdecke University, Witten, Germany.

Objectives: To explore whether placement of a soft cortical membrane can restore and regenerate the original alveolar ridge contour in deficient sockets.

Materials And Methods: One Beagle dog was used in this proof-of-principle evaluation. In a first intervention, a standardized buccal dehiscence defect was artificially created at the distal roots of the 3rd and 4th mandibular premolars. Read More

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http://dx.doi.org/10.1016/j.aanat.2020.151524DOI Listing

Hydroxyapatite Nanoparticles as Injectable Bone Substitute Material in a Vertical Bone Augmentation Model.

In Vivo 2020 May-Jun;34(3):1053-1061

Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Aim: The aim of this in vivo study was to evaluate the utility of bone graft gel containing hydroxyapatite nanoparticles in promoting bone regeneration in a mouse model of vertical bone augmentation.

Materials And Methods: Gel implants with high and low viscosity were compared for their bone regenerating ability. Bone formation at 12 weeks and material reactions were observed radiographically and histologically. Read More

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http://dx.doi.org/10.21873/invivo.11875DOI Listing
December 2019

Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord.

Stem Cells Int 2020 5;2020:1321283. Epub 2020 Apr 5.

Translational Platform for Regenerative Medicine, Mossakowski Medical Research Centre, Polish Academy of Sciences, Poland.

Objective: Bone defects or atrophy may arise as a consequence of injury, inflammation of various etiologies, and neoplastic or traumatic processes or as a result of surgical procedures. Sometimes the regeneration process of bone loss is impaired, significantly slowed down, or does not occur, e.g. Read More

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http://dx.doi.org/10.1155/2020/1321283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142388PMC

Review on calcium- and magnesium-based silicates for bone tissue engineering applications.

J Biomed Mater Res A 2020 May 30;108(7):1546-1562. Epub 2020 Mar 30.

Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

Bone is a self-engineered structural component of the human body with multifaceted mechanical strength, which provides indomitable support to the effective functioning of the human body. It is indispensable to find a suitable biomaterial for substituting the bone as the bone substitute material requirement is very high due to the rate of bone fracture and infection lead to osteoporosis in human beings increases rapidly. It is not an easy task to design a material with good apatite deposition ability, a faster rate of dissolution, superior resorbability, high mechanical strength, and significant bactericidal activity. Read More

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http://dx.doi.org/10.1002/jbm.a.36925DOI Listing

Alveolar Socket Preservation with Different Autologous Graft Materials: Preliminary Results of a Multicenter Pilot Study in Human.

Materials (Basel) 2020 Mar 5;13(5). Epub 2020 Mar 5.

Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.

Background: The histological and histomorphometrical results were evaluated between vital whole and non-vital endodontically treated teeth used as autologous grafts in post-extractive socket preservation procedures.

Methods: Twenty-eight patients (average age 51.79 ± 5. Read More

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http://dx.doi.org/10.3390/ma13051153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084996PMC

Evaluation of Goose-beak Bone Particles for Dentoalveolar Reconstruction in Dogs.

In Vivo 2020 Mar-Apr;34(2):609-614

Department of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea

Background/aim: Tooth extraction is a common procedure in dental clinics. Tooth extraction can destroy gingiva, alveolar bone, periodontal ligaments and cement. If dental sockets are left as extracted, it will result in loss of teeth, as well as voice and aesthetic problems. Read More

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http://dx.doi.org/10.21873/invivo.11814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157880PMC
October 2019

Influence of Geometry and Architecture on the Success of 3D-Printed Scaffolds for Spinal Fusion.

Tissue Eng Part A 2020 Mar 26. Epub 2020 Mar 26.

Northwestern University Department of Orthopaedic Surgery, Chicago, Illinois.

We previously developed a recombinant growth factor-free, three-dimensional (3D)-printed material comprising hydroxyapatite (HA) and demineralized bone matrix (DBM) for bone regeneration. This material has demonstrated the capacity to promote re-mineralization of the DBM particles within the scaffold struts and shows potential to promote successful spine fusion. Here, we investigate the role of geometry and architecture in osteointegration, vascularization, and facilitation of spine fusion in a preclinical model. Read More

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http://dx.doi.org/10.1089/ten.TEA.2020.0004DOI Listing

Efficacy of a Standalone Microporous Ceramic vs. Autograft in Instrumented Posterolateral Spinal Fusion; a Multicenter, Randomized, Intra-patient Controlled, Non-inferiority Trial.

Spine (Phila Pa 1976) 2020 Feb 19. Epub 2020 Feb 19.

Department of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Study Design: Patient and observer blinded, multicenter, randomized, intra-patient controlled, non-inferiority trial.

Objective: To determine non-inferiority of a biphasic calcium-phosphate (AttraX® Putty) as a bone graft substitute for autograft in instrumented posterolateral fusion (PLF).

Summary Of Background Data: Spinal fusion with autologous bone graft is a frequently performed surgical treatment. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003440DOI Listing
February 2020

Lipoconstruct surface topography grating size influences vascularization onset in the dorsal skinfold chamber model.

Acta Biomater 2020 04 8;106:136-144. Epub 2020 Feb 8.

Division of Plastic Surgery and Hand Surgery, University Hospital Zurich, Raemistrasse 100, Zurich 8091, Switzerland. Electronic address:

After skin tissue injury or pathological removal, vascularization timing is paramount in graft survival. As full thickness skin grafts often fail to become perfused over larger surfaces, split-thickness grafts are preferred and can be used together with biomaterials, which themselves are non-angiogenic. One way of promoting vascular ingrowth is to "pre-vascularize" an engineered substitute by introducing endothelial cells (ECs). Read More

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http://dx.doi.org/10.1016/j.actbio.2020.01.050DOI Listing

Staged implant placement after defect regeneration using biphasic calcium phosphate materials with different surface topographies in a minipig model.

Clin Oral Investig 2020 Jan 24. Epub 2020 Jan 24.

Department of Oral Surgery and Central Admittance, University Hospital, Heichrich-Heine-University, Düsseldorf, Germany.

Objective: To assess the influence of biphasic calcium phosphate materials with different surface topographies on bone formation and osseointegration of titanium implants in standardized alveolar ridge defects.

Materials And Methods: Standardized alveolar ridge defects (6 × 6 mm) were created in the mandible of 8 minipigs and filled with three biphasic calcium phosphate materials (BCP1-3, 90% tricalcium phosphate/10% hydroxyapatite) with different surface properties (micro- and macroporosities) as well as a bovine-derived natural bone mineral (NBM) as a control. At 12 weeks, implants were placed into the augmented defects. Read More

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http://dx.doi.org/10.1007/s00784-020-03206-7DOI Listing
January 2020

Socket preservation using eggshell-derived nanohydroxyapatite with platelet-rich fibrin as a barrier membrane: a new technique.

J Korean Assoc Oral Maxillofac Surg 2019 Dec 26;45(6):332-342. Epub 2019 Dec 26.

Department of Oral and Maxillofacial Pathology, Sibar Institute of Dental Sciences, Guntur, India.

Objectives: Socket grafting is vital to prevent bone resorption after tooth extraction. Several techniques to prevent resorption have been described, and various bone graft substitutes have been developed and used with varying success. We conducted this pilot study to evaluate the performance of nanohydroxyapatite (nHA) derived from chicken eggshells in socket preservation. Read More

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http://dx.doi.org/10.5125/jkaoms.2019.45.6.332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955417PMC
December 2019

Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs.

Dent J (Basel) 2020 Jan 9;8(1). Epub 2020 Jan 9.

1st Department of Pathology, Medical School, University of Athens, 75 M. Assias Street, 11527 Athens, Greece.

Regeneration of large jaw bone defects still remains a clinical challenge. To avoid incomplete bone repair, bone grafts have been advocated to support the healing process. This study comparatively evaluated new bone formation among a synthetic graft substitute, a human bone derivative, and a bovine xenograft. Read More

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http://dx.doi.org/10.3390/dj8010007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175133PMC
January 2020

Porous Titanium Granules in comparison with Autogenous Bone Graft in Femoral Osseous Defects: A Histomorphometric Study of Bone Regeneration and Osseointegration in Rabbits.

Biomed Res Int 2019 14;2019:8105351. Epub 2019 Dec 14.

Austrian Cluster for Tissue Regeneration, Vienna, Austria.

Background: The high resorption rate of autogenous bone is a well-documented phenomenon that can lead to insufficient bone quality and quantity in an augmented area. Nonresorbable bone substitutes might perform better than autogenous bone in certain applications if they are able to provide adequate bone formation and graft osseointegration.

Purpose: The aim of this study was to compare the osseous regeneration and graft integration in standardized defects in the rabbit femur treated either with porous titanium granules or autogenous osseous graft. Read More

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http://dx.doi.org/10.1155/2019/8105351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935454PMC
December 2019

Eye Socket Regeneration and Reconstruction.

Curr Eye Res 2020 Mar 10;45(3):253-264. Epub 2020 Jan 10.

Department of Ophthalmology, University Hospital Duesseldorf, Duesseldorf, Germany.

When an eye has become irreversibly blind or painful it is removed by enucleation or evisceration. The resulting anophthalmic socket usually receives a volume replacing implant and is subsequently fitted with a prosthetic shell for adequate cosmesis. Trauma, tumour or immunological pathomechanisms can induce loss of bone, orbital soft tissue volume, and conjunctival contraction or implant exposure, which result in difficult or impossible prosthesis wear. Read More

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http://dx.doi.org/10.1080/02713683.2020.1712423DOI Listing

Efficacy and safety of bone substitutes in lumbar spinal fusion: a systematic review and network meta-analysis of randomized controlled trials.

Eur Spine J 2020 Jun 23;29(6):1261-1276. Epub 2019 Dec 23.

Department of Orthopedic Oncology, Tianjin Hospital, No. 406, Jiefang Southern Road, Hexi District, Tianjin, 300211, China.

Purpose: A variety of alternative grafts to autologous iliac crest bone (ICBG) have been developed for lumbar spondylodesis, due to frequent complications following ICBG harvest. The optimal alternative graft to ICBG, however, remains elusive till now. The purpose of this study was to compare the efficacy and safety of fusion materials in lumbar degeneration diseases and to provide a ranking spectrum of the grafts. Read More

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http://dx.doi.org/10.1007/s00586-019-06257-xDOI Listing

Release of Antibiotics Out of a Moldable Collagen-β-Tricalciumphosphate-Composite Compared to Two Calcium Phosphate Granules.

Materials (Basel) 2019 Dec 5;12(24). Epub 2019 Dec 5.

Pius Hospital, Universitätsklinik für Orthopädie und Unfallchirurgie, 26121 Oldenburg, Germany.

Bacterial bone infections after revision surgeries and diseases, like osteomyelitis, are still a challenge with regard to surgical treatments. Local bone infections were treated with antibiotics directly or by controlled drug-releasing scaffolds, like polymethylmethacrylate (PMMA) spheres, which have to be removed at a later stage, but there is a risk of a bacterial contamination during the removement. Therefore, biomaterials loaded with antibiotics for controlled release could be the method of choice: The biomaterials degrade during the drug release, therefore, there is no need for a second surgery to remove the drug eluting agent. Read More

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http://dx.doi.org/10.3390/ma12244056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947585PMC
December 2019

Application of a Promising Bone Graft Substitute in Bone Tissue Regeneration: Characterization, Biocompatibility, and Animal Study.

Biomed Res Int 2019 31;2019:1614024. Epub 2019 Oct 31.

Department of Prosthodontics, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.

The purpose of the present study was to investigate the effect of local hydroxyapatite (HA) combined with extracted sea cucumber () collagen as a promising bone graft substitute on bone remodeling. Fourier-transform infrared spectroscopy, X-ray diffractometry, transmission electron microscopy, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and Sprague-Dawley rat model were used to characterize the microstructure, cytotoxicity, and bone-healing properties of the investigated biocomposite material. Analytical results found that the hydrothermal reaction-synthesized local HA had a hexagonal close-packed structure. Read More

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http://dx.doi.org/10.1155/2019/1614024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877934PMC

Fabrication and Histological Evaluation of Porous Carbonate Apatite Block from Gypsum Block Containing Spherical Phenol Resin as a Porogen.

Materials (Basel) 2019 Dec 2;12(23). Epub 2019 Dec 2.

Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

The utility of carbonate apatite (COAp) as a bone substitute has been demonstrated. The feasibility of fabricating macroporous COAp was evaluated through a two-step dissolution-precipitation reaction using gypsum as the precursor and spherical phenol resin as the porogen. Porogen-containing gypsum was heated to burn out the porogen and to fabricate macroporous structures. Read More

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http://dx.doi.org/10.3390/ma12233997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926850PMC
December 2019

An Bone Defect Model to Evaluate Bone Substitutes and Associated Bone Regeneration Processes.

Tissue Eng Part C Methods 2020 Jan;26(1):56-65

Department of Trauma and Orthopedic Surgery, Experimental Trauma Surgery, University Medical Center Schleswig-Holstein, Kiel, Germany.

The increased incidence of bone defects, especially in cases of comminuted fractures or bone tumor resections demands suitable bone grafts and substitutes. The aim of this study was to establish an bone defect model to evaluate new bone substitutes and associated repair processes under controlled conditions. Femoral heads derived from patients undergoing total hip replacement were cut into cylinders (20 mm diameter, 7 mm height). Read More

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http://dx.doi.org/10.1089/ten.TEC.2019.0274DOI Listing
January 2020

Tissue Engineering and Regenerative Medicine Therapies for Cell Senescence in Bone and Cartilage.

Tissue Eng Part B Rev 2020 Feb 6;26(1):64-78. Epub 2020 Jan 6.

Department of Materials Science and Engineering, East China University of Science and Technology, Shanghai, P.R. China.

The bone repair and substitute have been developed for decades with the bone defect repair applied successfully in clinical. However, implant complications may occur in more challenging situations, bone cell senescence and osteoporosis (OP). Due to certain microenvironment conditions, including hormonal, nutritional, and aging factors, the bone cell responses are regulated to alteration and end into cell senescence and OP. Read More

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http://dx.doi.org/10.1089/ten.TEB.2019.0215DOI Listing
February 2020

Role of Synthetic Hydroxyapatite-In Socket Preservation: A Systematic Review and Meta-analysis.

J Contemp Dent Pract 2019 Aug 1;20(8):987-993. Epub 2019 Aug 1.

Department of Periodontics, Ar Rass College of Dentistry, University of Qassim, Kingdom of Saudi Arabia.

Since a long time, the preservation of the socket is emphasized for various reasons. Many studies have suggested the ridge preservation through socket grafting using various bone graft substitute materials (GSMs). But none of the studies suggested the material of choice for the grafting. Read More

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[Bone Replacement and Bone Formation].

Z Orthop Unfall 2019 Dec 3;157(6):715-728. Epub 2019 Dec 3.

Autologous cancellous bone grafting remains the gold standard in the treatment of bone defects as it meets all requirements (osteoinduction, osteoconduction, osteointegration). Over time, bone replacement materials will become increasingly important in orthopedics and trauma surgery. The main representatives of bone replacement materials are calcium phosphates (ceramics and cements). Read More

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http://dx.doi.org/10.1055/a-0756-2768DOI Listing
December 2019

A novel unidirectional porous β-tricalcium phosphate grafting for vertebral fracture in the elderly: preliminary case series.

J Rural Med 2019 Nov 20;14(2):211-215. Epub 2019 Nov 20.

Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Japan.

To treat vertebral fractures with posterior wall injury in the elderly, vertebral bone grafting is generally performed through a posterior transpedicular approach, combined with pedicle screw fixation. An autologous bone is ideal to treat this disorder. However, harvesting autologous bones from the elderly with osteoporosis is limited by the amount and quality of available autologous bone. Read More

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http://dx.doi.org/10.2185/jrm.3017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877923PMC
November 2019

Simulated Performance of a Xenohybrid Bone Graft (SmartBone) in the Treatment of Acetabular Prosthetic Reconstruction.

J Funct Biomater 2019 Nov 22;10(4). Epub 2019 Nov 22.

Industrie Biomediche Insubri SA, 6805 Mezzovico-Vira, Switzerland.

Total hip arthroplasty (THA) is a surgical procedure for the replacement of hip joints with artificial prostheses. Several approaches are currently employed in the treatment of this kind of defect. Overall, the most common method involves using a quite invasive metallic support (a Burch-Schneider ring). Read More

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http://dx.doi.org/10.3390/jfb10040053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963854PMC
November 2019

Comparative Efficacy of Commonly Available Human Bone Graft Substitutes as Tested for Posterolateral Fusion in an Athymic Rat Model.

Int J Spine Surg 2019 Oct 31;13(5):437-458. Epub 2019 Oct 31.

Cedars-Sinai Medical Center, Los Angeles, California.

Background: Insufficient data exist on bone graft substitute materials efficacy; two thirds lack any clinical data.1,2 This prospective animal study identified efficacy differences among commercially available materials of several classes.

Methods: Historically validated muscle pouch osteoinduction study (OIS) and posterolateral fusion (PLF) were performed in an athymic rat model. Read More

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http://dx.doi.org/10.14444/6059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836878PMC
October 2019

Maxillary sinus floor elevation using hydroxyapatite nano particles vs tenting technique with simultaneous implant placement: A randomized clinical trial.

Clin Implant Dent Relat Res 2019 Dec 19;21(6):1241-1252. Epub 2019 Nov 19.

Oral & Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Purpose: The present study was conducted to evaluate the amount of bone height gain, density values, and implant stability after maxillary sinus floor elevation using graftless tenting technique or the use of Hydroxyapatite Nanoparticles bone substitute for augmentation with simultaneous implant placement.

Materials And Methods: A total of 20 sinuses with a residual alveolar bone height ranging from 4-6 mm were divided into two groups and underwent sinus augmentation using nano hydroxyapatite bone substitute material and the graftless tenting technique with simultaneous implant placement. Computed tomography CT scans and ISQ measurements were conducted to evaluate bone quality, quantity, and implant stability. Read More

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http://dx.doi.org/10.1111/cid.12859DOI Listing
December 2019

Thiol-ene Hydrogels for Local Delivery of PTH for Bone Regeneration in Critical Size defects.

J Orthop Res 2020 Mar 25;38(3):536-544. Epub 2019 Nov 25.

Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts.

Neither allograft nor commercially available bone graft substitutes provide the same quality of bone healing as autograft. Incorporation of bioactive molecules like parathyroid hormone (PTH) within bone graft substitute materials may provide similar, if not better treatment options to grafting. The goal of this work was to develop a biomaterial system for the local delivery of PTH to large bone defects for promoting bone regeneration. Read More

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http://dx.doi.org/10.1002/jor.24502DOI Listing

Impact of salivary contamination during placement of implants with simultaneous bony augmentation in iliac bone in sheep.

Br J Oral Maxillofac Surg 2019 12 29;57(10):1131-1136. Epub 2019 Oct 29.

Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden.

Our aim was to investigate the possible impact of contamination with saliva on osseointegration during placement of implants with simultaneous bone augmentation. Six hemispheric shape bone defects (8mm in diameter×4mm deep) were prepared in each iliac bone of six sheep. A dental implant (2. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.10.302DOI Listing
December 2019

Balancing Purification and Ultrastructure of Naturally Derived Bone Blocks for Bone Regeneration: Report of the Purification Effort of Two Bone Blocks.

Materials (Basel) 2019 Oct 2;12(19). Epub 2019 Oct 2.

Department of Materials Test Engineering (WPT), TU Dortmund University, Dortmund 44227, Germany.

The present publication reports the purification effort of two natural bone blocks, that is, an allogeneic bone block (maxgraft, botiss biomaterials GmbH, Zossen, Germany) and a xenogeneic block (SMARTBONE, IBI S.A., Mezzovico-Vira, Switzerland) in addition to previously published results based on histology. Read More

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http://dx.doi.org/10.3390/ma12193234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803862PMC
October 2019
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2.651 Impact Factor

[Preliminary application assessment of individualized three-dimensional printing titanium mesh combined with guided bone regeneration for repairing alveolar bone defects].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Sep;54(9):623-627

Department of Oral Implantology, Stomatological Hospital of Chongqing Medical University & Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences & Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401120, China.

To preliminarily evaluate the clinical effect of the three-dimensional (3D) printing individualized titanium mesh combined with guided bone regeneration technology for repairing alveolar bone defects. Six patients with alveolar bone defects (4 males and 2 females, aged 18-27 years, mean 23.3 years) were selected from the Department of Oral Implantology, Stomatological Hospital of Chongqing Medical University from January to June 2018. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.09.008DOI Listing
September 2019

Comparison of microsurgical and macrosurgical technique using bioactive synthetic bone graft and collagen membrane for an implant site development: A randomized controlled clinical trial.

J Indian Soc Periodontol 2019 Sep-Oct;23(5):448-460

Department of Periodontology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India.

Background: Implant site development can be effective in minimizing postextraction alveolar ridge resorption in the esthetic region. Microsurgical approach has demonstrated substantial improvement in soft-tissue architecture.

Aim And Objectives: The aim of the present study was to evaluate and compare the efficacy of microsurgical technique with conventional one for implant site development utilizing biphasic hydroxyapatite/beta-tricalcium phosphate bone graft substitute and collagen membrane. Read More

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http://dx.doi.org/10.4103/jisp.jisp_738_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737851PMC
September 2019

3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion.

Tissue Eng Part A 2020 Feb 26;26(3-4):157-166. Epub 2019 Sep 26.

Department of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.

Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) and human demineralized bone matrix (DBM) in a poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds to promote osteointegration in rats, with an end goal of spine fusion without the need for recombinant growth factor. Spine fusion was evaluated by manual palpation, and osteointegration and bone formation within scaffold struts were evaluated by laboratory and synchrotron microcomputed tomography and histology. Read More

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http://dx.doi.org/10.1089/ten.TEA.2019.0166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044791PMC
February 2020
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Biphasic calcium phosphate with submicron surface topography in an model of instrumented posterolateral spinal fusion.

JOR Spine 2018 Dec 28;1(4):e1039. Epub 2018 Nov 28.

Kuros Biosciences BV Bilthoven The Netherlands.

As spinal fusions require large volumes of bone graft, different bone graft substitutes are being investigated as alternatives. A subclass of calcium phosphate materials with submicron surface topography has been shown to be a highly effective bone graft substitute. In this work, a commercially available biphasic calcium phosphate (BCP) with submicron surface topography (MagnetOs; Kuros Biosciences BV) was evaluated in an model of instrumented posterolateral fusion. Read More

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http://doi.wiley.com/10.1002/jsp2.1039
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http://dx.doi.org/10.1002/jsp2.1039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686792PMC
December 2018
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Vascular bundle transplantation combined with porous bone substituted scaffold for the treatment of early-stage avascular necrosis of femoral head.

Med Hypotheses 2019 Nov 19;132:109374. Epub 2019 Aug 19.

Department of Orthopaedics, Beijing Friendship Hospital Affiliated of Capital Medical University, Beijing, China.

Various reasons leading to disruption of blood supply will result in avascular femoral head necrosis. Decompression of lesion area, structural support to subchondral bone, and rebuilding of blood supply system are the keys for a successful hip preserve surgery. Reconstruction of local vascular network is always a huge challenge in clinical. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.109374DOI Listing
November 2019

Factors affecting stability after medial opening wedge high tibial osteotomy using locking plate: A cadaveric study.

Knee 2019 Dec 21;26(6):1313-1322. Epub 2019 Aug 21.

TK Orthopedic surgery, Seongnam-si, Gyeonggi-do, Republic of Korea. Electronic address:

Objectives: To investigate the effect of screw length, lateral hinge fracture, and gap filling on stability after medial opening wedge high tibial osteotomy (MOW HTO) using a locking plate.

Methods: Forty tibiae from fresh-frozen cadavers were randomly allocated into five groups. Group A was bicortically fixated, while Group B and Group C were unicortically fixated: 90% and 55% of drilled tunnel length, respectively. Read More

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http://dx.doi.org/10.1016/j.knee.2019.07.016DOI Listing
December 2019
2 Reads

Biomaterial-based bone regeneration and soft tissue management of the individualized 3D-titanium mesh: An alternative concept to autologous transplantation and flap mobilization.

J Craniomaxillofac Surg 2019 Oct 19;47(10):1633-1644. Epub 2019 Jul 19.

FORM-Lab, Frankfurt Oral Regenerative Medicine, Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Germany.

Three-dimensional augmentation in severely atrophic bone and after cancer resection is a challenging clinical indication that is mostly solved using autologous bone transplantation. The development of the digital technique along with the additive manufacturing and three-dimensional (3D) printing opened new avenues for reconstructive oral and maxillofacial surgery. Therefore, patient-specific titanium mesh is a novel means of stabilizing the augmentation region using particulate bone substitute materials (BSMs) combined with autologous bone as a minimally invasive concept. Read More

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http://dx.doi.org/10.1016/j.jcms.2019.07.020DOI Listing
October 2019
3 Reads

Characterisation and in vitro and in vivo evaluation of supercritical-CO2-foamed β-TCP/PLCL composites for bone applications.

Eur Cell Mater 2019 08 5;38:35-50. Epub 2019 Aug 5.

Faculty of Medicine and Health Technology, FI-33014 Tampere University, Tampere,

Most synthetic bone grafts are either hard and brittle ceramics or paste-like materials that differ in applicability from the gold standard autologous bone graft, which restricts their widespread use. Therefore, the aim of the study was to develop an elastic, highly porous and biodegradable β-tricalciumphosphate/poly(L-lactide-co-ε-caprolactone) (β-TCP/PLCL) composite for bone applications using supercritical CO2 foaming. Ability to support osteogenic differentiation was tested in human adipose stem cell (hASC) culture for 21 d. Read More

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http://dx.doi.org/10.22203/eCM.v038a04DOI Listing
August 2019
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Bone Regeneration Using a Three-Dimensional Hexahedron Channeled BCP Block Combined with Bone Morphogenic Protein-2 in Rat Calvarial Defects.

Materials (Basel) 2019 Jul 31;12(15). Epub 2019 Jul 31.

Department of Prosthodontics, Dental Research Institute, Dental and Life Science Institute, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea.

It is important to obtain sufficient bone mass before implant placement on alveolar bone, and synthetic bone such as biphasic calcium phosphate (BCP) has been studied to secure this. This study used a BCP block bone with a specific structure of the three-dimensional (3D) hexahedron channel and coating with recombinant human bone morphogenetic protein-2 (rhBMP-2) impregnated carboxymethyl cellulose (CMC) was used to examine the enhancement of bone regeneration of this biomaterial in rat calvarial defect. After the preparation of critical-size calvarial defects in fifteen rats, defects were divided into three groups and were implanted with the assigned specimen (n = 5): Boneplant (untreated 3D hexahedron channeled BCP block), Boneplant/CMC (3D hexahedron channeled BCP block coated with CMC), and Boneplant/CMC/BMP (3D hexahedron channeled BCP block coated with CMC containing rhBMP-2). Read More

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http://dx.doi.org/10.3390/ma12152435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696350PMC

Experimental Evaluation of the Properties of 3D Porous Bone Substitute Based on Calcium Phosphate on the Model of Monocortical Diaphysial Femur Defect in Rats.

Bull Exp Biol Med 2019 Jul 26;167(3):400-403. Epub 2019 Jul 26.

Faculty of Fundamental Medicine, Moscow, Russia.

A new alloplastic high-permeable material based on tricalcium phosphate with Kelvin architectonics created by stereolithographic 3D-printing was studied in vivo. A monocortical defect of the femur was modeled in rats and the material was implanted into the defect area. In 24 weeks, the animals were euthanized and histological examination of the defect area was performed. Read More

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http://dx.doi.org/10.1007/s10517-019-04536-7DOI Listing

Synthesis and Evaluation of BMMSC-seeded BMP-6/nHAG/GMS Scaffolds for Bone Regeneration.

Int J Med Sci 2019 10;16(7):1007-1017. Epub 2019 Jun 10.

Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China.

Bioactive scaffolding materials and efficient osteoinductive factors are key factors for bone tissue engineering. The present study aimed to mimic the natural bone repair process using an osteoinductive bone morphogenetic protein (BMP)-6-loaded nano-hydroxyapatite (nHA)/gelatin (Gel)/gelatin microsphere (GMS) scaffold pre-seeded with bone marrow mesenchymal stem cells (BMMSCs). BMP-6-loaded GMSs were prepared by cross-linking and BMP-6/nHAG/GMS scaffolds were fabricated by a combination of blending and freeze-drying techniques. Read More

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http://dx.doi.org/10.7150/ijms.31966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643122PMC
February 2020
2.003 Impact Factor

Use of a biphasic cement bone substitute in the management of metaphyseal fractures.

J Clin Orthop Trauma 2019 Jul-Aug;10(4):789-791. Epub 2018 Aug 10.

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

Objectives: In recent years, the increase in utilisation of bone substitutes in the reconstruction of bone defects has been fuelled by donor site complications associated with autologous bone harvesting. However the ability of bone substitute to stimulate bone union while maintaining fracture reduction has been a topic of debate. Cerament Bone Void Filler (CBVF) is a novel biphasic and injectable ceramic bone substitute that has high compressive strength and the ability to promote cancellous bone healing. Read More

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http://dx.doi.org/10.1016/j.jcot.2018.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611836PMC
August 2018
6 Reads

Do osteoconductive bone substitutes result in similar bone regeneration for maxillary sinus augmentation when compared to osteogenic and osteoinductive bone grafts? A systematic review and frequentist network meta-analysis.

Int J Oral Maxillofac Surg 2020 Jan 21;49(1):107-120. Epub 2019 Jun 21.

Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy; IRCCS Orthopedic Institute Galeazzi, Milan, Italy.

The purpose of this network meta-analysis was to identify the most effective biomaterials producing higher new bone formation (NBF) and lower residual graft (RG) and connective tissue (CT) following maxillary sinus augmentation (MSA), and to generate a ranking based on their performance. The MEDLINE, Embase, and CENTRAL databases were searched to identify randomized controlled trials (RCTs) published until March 2018, evaluating histomorphometric outcomes after MSA. Predictor variables were autogenous bone (AB), allografts (AG), xenografts (XG), alloplastic bone (AP), AB+XG, AB+AP, AG+XG, XG+AP, and grafts combined with autologous platelet concentrates/recombinant growth factors, mesenchymal stem cells (MSCs), or recombinant bone morphogenetic proteins (BMPs). Read More

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http://dx.doi.org/10.1016/j.ijom.2019.05.004DOI Listing
January 2020
9 Reads

Graftless sinus floor augmentation with an internal-port implant: long-term experience.

Quintessence Int 2019 ;50(7):560-567

Objective: The objective was to assess the outcome of graftless sinus floor augmentation associated with dental implant placement performed with an implant system that has an internal port and screw, combined with the osteotome technique.

Method And Materials: Between 2012 and 2018, 722 titanium-aluminum-vanadium implants (Ti-6Al-4V ELI, diameter 3.75/4. Read More

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http://dx.doi.org/10.3290/j.qi.a42656DOI Listing
November 2019
9 Reads

A Self-Made, Reusable, and Adjustable Device for Making Burr Hole Bone Plugs: Doing More with Less.

World Neurosurg 2019 Sep 8;129:298-301. Epub 2019 Jun 8.

Department of Neurosurgery, Ghaem Teaching Hospital, Faculty of Medicine, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Burr hole craniotomy is a daily procedure in neurosurgery. Defects after burr hole craniotomies will not spontaneously heal and can result in skin dents and cosmetic dissatisfaction. We have introduced a self-made, reusable, and adjustable bone plug packer to use in the repair of burr holes via packing of autologous bone dust. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.05.257DOI Listing
September 2019
7 Reads

In vivo study of microarc oxidation coated Mg alloy as a substitute for bone defect repairing: Degradation behavior, mechanical properties, and bone response.

Colloids Surf B Biointerfaces 2019 Sep 23;181:349-359. Epub 2019 May 23.

Institute for Advanced Ceramics, Harbin Institute of Technology, Harbin 150001, China; Key Laboratory of Advanced Structural-Functional Integration Materials & Green Manufacturing Technology, Harbin Institute of Technology, Harbin, 150001, China.

Large segmental bone defect healing remains a great challenge in clinic. Limited by the source of autograft, bone graft substitute tends to be the research focus. In the present study, we propose a strategy by using microarc oxidation (MAO) coated magnesium scaffold as a large segmental bone graft substitute, utilizing its combination of strength, degradability, and controllable corrosion rate. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.05.052DOI Listing
September 2019
7 Reads

Clinical Outcome of Beta-Tricalcium Phosphate Use for Bone Defects after Operative Treatment of Benign Tumors.

Clin Orthop Surg 2019 Jun 9;11(2):233-236. Epub 2019 May 9.

Department of Orthopedic Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.

Background: We investigated the clinical outcome in patients whose cavitary bone defects were treated with beta-tricalcium phosphate (β-TCP) after surgical removal of benign tumors.

Methods: Between March 2015 and December 2015, 20 patients who underwent operation for bone tumors were enrolled into this study and prospectively followed up for a median period of 28.1 months. Read More

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http://dx.doi.org/10.4055/cios.2019.11.2.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526132PMC
June 2019
2 Reads

Biological and technical outcomes of restored implants after maxillary sinus augmentation-Results at 1-year loading.

Clin Oral Implants Res 2019 Sep 19;30(9):849-860. Epub 2019 Jun 19.

School of Dentistry, The University of Queensland, Herston, Queensland, Australia.

Objective: To report biological and technical outcomes of implant-supported restorations placed into previously maxillary sinus floor augmentation using the lateral wall approach (MSA) using anorganic bovine bone mineral (ABBM) + autogenous bone (AB) (control group) or collagen-stabilized ABBM (test group).

Materials And Methods: Single implant was placed 6 months after MSA in 27 control and 26 test patients. Fixed restorations were delivered 12 weeks later and reviewed 12 months after function. Read More

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http://dx.doi.org/10.1111/clr.13489DOI Listing
September 2019