Search Our Scientific Publications & Authors

Materials (Basel) 2022 Jun 7;15(12). Epub 2022 Jun 7.

Department of Periodontology, School of Dentistry, Chosun University, Gwangju 61452, Korea.

This prospective single-arm clinical study aimed to radiographically and histomorphometrically evaluate the efficacy of the lateral approach for sinus floor elevation (LSFE) using biomimetic octacalcium phosphate (OCP) synthetic bone graft (Bontree). LSFE using Bontree was performed on 10 patients (15 implant placement sites) willing to undergo implant surgery, followed by implant placements after 6 months of the healing period. The vertical bone height (VBH) and Hounsfield unit (HU) values at each implant placement site were evaluated radiographically using cone-beam computed tomography at baseline immediately after surgery (T1) and 6 months after surgery (T2). Read More

J Clin Periodontol 2022 Jun 17. Epub 2022 Jun 17.

Division of Plastic and Reconstructive Surgery, School of Medicine, Stanford University, Palo Alto, California, USA.

Aim: Autologous bone grafts consolidate faster than bone graft substitutes (BGSs) but resorb over time, which compromises implant support. We hypothesized that differences in consolidation rates affected the mechanical properties of grafts and implant stability, and tested whether a pro-osteogenic protein, liposomal WNT3A (L-WNT3A), could accelerate graft consolidation.

Materials And Methods: A transgenic mouse model of sinus augmentation with immunohistochemistry, enzymatic assays, and histology were used to quantitatively evaluate the osteogenic properties of autografts and BGSs. Read More

Int J Mol Sci 2022 Jun 5;23(11). Epub 2022 Jun 5.

Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.

The reconstruction of bone defects remains challenging. The utilization of bone autografts, although quite promising, is limited by several drawbacks, especially substantial donor site complications. Recently, strontium (Sr), a bioactive trace element with excellent osteoinductive, osteoconductive, and pro-angiogenic properties, has emerged as a potential therapeutic agent for bone repair. Read More

Clin Orthop Relat Res 2022 May 30. Epub 2022 May 30.

Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, Japan.

Background: Bone grafting is widely used to treat large bone defects. A porous composite of a bioactive octacalcium phosphate material with gelatin sponge (OCP/Gel) has been shown to biodegrade promptly and be replaced with new bone both in animal models of a membranous bone defect and a long bone defect. However, it is unclear whether OCP/Gel can regenerate bone in more severe bone defects, such as a critical-size transcortical defect. Read More

Musculoskelet Surg 2022 May 22. Epub 2022 May 22.

Reading Shoulder Unit, Reading, UK.

Introduction: Glenoid bone loss is a commonly encountered problem in complex primary and revision shoulder arthroplasty. Addressing glenoid bone loss is critical to avoid complications like early loosening, impingement, notching and instability. A large number of techniques like bone grafting using autograft or allograft, eccentric reaming, augmented base plates, patient-specific instrumentations and custom-made implants are available to tackle bone loss. Read More

Appl Biochem Biotechnol 2022 May 21. Epub 2022 May 21.

Department of Chemistry, Aarupadai Veedu Institute of Technology, Vinayaka Mission's Research Foundation (Deemed to be University), Rajiv Gandhi Salai, Paiyanoor, Kancheepuram District, 603104, Tamil Nadu, India.

In the past, bone fractures due to accidents were rectified by surgery and reconstruction of bone structure. In recent times, researchers have been made to find a solution by producing alternate biomaterials. Hydroxyapatite (HAp) is one of the most important bioactive materials used as a substitute for human hard tissue because of its composition being very similar to human bones and teeth. Read More

Materials (Basel) 2022 May 5;15(9). Epub 2022 May 5.

Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, China.

Dendritic cells (DCs) are recognized as the most effective antigen-presenting cells at present. DCs have corresponding therapeutic effects in tumor immunity, transplantation immunity, infection inflammation and cardiovascular diseases, and the activation of T cells is dependent on DCs. However, normal bone-marrow-derived Dendritic cells (BMDCs) cultured on conventional culture plates are easy to be activated during culturing, and it is difficult to imitate the internal immune function. Read More

Mater Today Bio 2022 Mar 20;14:100267. Epub 2022 Apr 20.

Univ. Lille, INSERM, CHU Lille, U1008-Controlled Drug Delivery Systems and Biomaterials, Lille, France.

Most existing preclinical models for evaluating the biosafety and bone-regeneration efficacy of innovative bone substitute materials (BSMs) or tissue engineering (TE) constructs only consisted of a single-site defect and the anatomical locations of defect varied drastically. While the compelling evidence showed that the bone healing pattern is location-dependent, owing to developmental, structural, and functional differences of anatomical locations, this is particularly true for the craniofacial region. Taking this into account, the bone healing efficiency of a BSM shown at one anatomical defect location cannot ensure the same impact at another. Read More

Biomater Sci 2022 May 31;10(11):2789-2816. Epub 2022 May 31.

Biomedical Engineering and Technology Lab, Mechanical engineering discipline, PDPM Indian Institute of Information Technology, Design & Manufacturing Jabalpur, India.

There are more than 2 million bone grafting procedures performed annually in the US alone. Despite significant efforts, the repair of large segmental bone defects is a substantial clinical challenge which requires bone substitute materials or a bone graft. The available biomaterials lack the adequate mechanical strength to withstand the static and dynamic loads while maintaining sufficient porosity to facilitate cell in-growth and vascularization during bone tissue regeneration. Read More

Clin Implant Dent Relat Res 2022 May 4. Epub 2022 May 4.

Department of Periodontics and Implantology, University Of Bern, Bern, Switzerland.

Background: An effective regenerative protocol is key to reestablish and maintain the hard and soft tissue dimensions over time. The choice of the graft material and its properties also could have an impact on the results. To prevent alveolar ridge dimensional changes, since numerous graft materials have been suggested and in the past years, a growing interest in teeth material has been observed as a valuable alternative to synthetic biomaterials. Read More

J Oral Implantol 2022 Apr 21. Epub 2022 Apr 21.

New York University Assistant Professor Biomaterials Division 433 1st Ave Room 842 UNITED STATES New York NY 10010 New York University.

To evaluate through histological and histomorphometric analysis of human biopsies the guided bone regeneration (GBR) potential of allograft, xenograft, and alloplastic materials in combination with resorbable membranes in sockets following extraction.  This randomized controlled clinical trial comprised three experimental groups and one negative control group (n=8). Thirty-two patients were randomized and pos-extraction sockets received either an allograft (human cancellous bone, freeze dried, DIZG, Berlin), xenograft (BioOss; Geistlich Biomaterials, Switzerland), or alloplast (biphasic calcium sulphate, Bondbone, MIS) graft material, while sockets of the negative control group were left empty for spontaneous healing. Read More

J Biomater Sci Polym Ed 2022 May 28:1-55. Epub 2022 May 28.

Department of Ceramic Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, India.

The rebuilding of the normal functioning of the damaged human body bone tissue is one of the main objectives of bone tissue engineering (BTE). Fabricated scaffolds are mostly treated as artificial supports and as materials for regeneration of neo bone tissues and must closely biomimetic the native extracellular matrix of bone. The materials used for developing scaffolds should be biodegradable, nontoxic, and biocompatible. Read More

Cureus 2022 Mar 9;14(3):e23010. Epub 2022 Mar 9.

Department of Health Services, University of Washington, Seattle, USA.

Background Multiple studies describe the outcomes of patients undergoing single-level and multilevel posterolateral lumbar fusion (PLF). However, a comparison of outcomes between single-level and two-level PLF is lacking. The aim of this prospective cohort study was to compare outcomes between single-level and two-level instrumented PLF. Read More

J Long Term Eff Med Implants 2022 ;32(1):77-84

Department of Periodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Guided bone regeneration (GBR) is considered as a prerequisite in some cases of implant dentistry. For this purpose, bone materials are commonly used. Calcium compounds and Ca-P based materials like hydroxyapatite (HA, Ca10 (PO4)6(OH)2), due to their similarity with the human bone, can be used as graft materials for bone regeneration. Read More

Odontology 2022 Mar 24. Epub 2022 Mar 24.

Department of Oral and Maxillofacial Surgery, Division of Clinical Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.

Surface modification of various materials using ultraviolet (UV) irradiation improves their wettability. The purpose of this study was to investigate the wettability of a β-tricalcium phosphate (TCP) surface and the composition changes and bioactivity of β-TCP after UV irradiation. We applied 172 nm UV treatment to a β-TCP surface and measured the contact angle before and after UV irradiation. Read More

J Funct Biomater 2022 Mar 9;13(1). Epub 2022 Mar 9.

Department of Research and Development, SigmaGraft Inc., 575 Sally Place, Fullerton, CA 92831, USA.

Bone is a complex hierarchical tissue composed of organic and inorganic materials that provide structure, support, and protection to organs. However, there are some critical size defects that are unable to regenerate on their own and therefore require clinical repair. Bone graft substitutes allow repair by providing a temporary resorbable device. Read More

Int J Biol Macromol 2022 May 10;208:243-259. Epub 2022 Mar 10.

Department of Bio & Nanotechnology, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India. Electronic address:

Our body is built to heal from inside out naturally but wide-ranging medical conditions necessitate the need for artificial assistance, and therefore, something that can assist the body to heal wounds and damaged tissues quickly and efficiently is of utmost importance. Tissue engineering technology helps to regenerate new tissue to replace the diseased or injured one. The technology uses biodegradable porous three-dimensional scaffolds for mimicking the structure and functions of the natural extracellular matrix. Read More

Materials (Basel) 2022 Mar 4;15(5). Epub 2022 Mar 4.

Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.

This study aimed to evaluate the biomechanical properties in vitro and the bone regeneration of whitlockite (WH) compared with hydroxyapatite (HA) or β-tricalcium phosphate (β-TCP)-based material. We investigated the morphology and phase composition of the bone grafts using a scanning electron microscope and X-ray diffractometer patterns and tested the compressive strength. Four circular defects of 8 mm in diameter were created on the calvaria of twelve rabbits. Read More

Tissue Eng Part C Methods 2022 05;28(5):193-201

Department of Dentistry, Biomaterials, Radboudumc, Nijmegen, The Netherlands.

Craniomaxillofacial bone defects represent a clinical challenge in the fields of maxillofacial surgery and (implant) dentistry. Regeneration of these bone defects requires the application of bone graft materials that facilitate new bone formation in a safe, reliable, and predictive manner. In addition to autologous bone graft, several types of (synthetic) bone substitute materials have become clinically available, and still major efforts are focused on improving such bone substitute materials by optimizing their properties. Read More

Bioact Mater 2022 Jul 10;13:64-81. Epub 2021 Nov 10.

Department of Chemical Engineering, University of Massachusetts Lowell, One University Avenue, Lowell, MA, 01854, USA.

Recent innovations in bone tissue engineering have introduced biomaterials that generate oxygen to substitute vasculature. This strategy provides the immediate oxygen required for tissue viability and graft maturation. Here we demonstrate a novel oxygen-generating tissue scaffold with predictable oxygen release kinetics and modular material properties. Read More

Materials (Basel) 2022 Feb 19;15(4). Epub 2022 Feb 19.

School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UK.

Advances in nanotechnology have been exploited to develop new biomaterials including nanocrystalline hydroxyapatite (nHA) with physical properties close to those of natural bone mineral. While clinical data are encouraging, relatively little is understood regarding bone cells' interactions with synthetic graft substitutes based on this technology. The aim of this research was therefore to investigate the in vitro response of both osteoblast cell lines and primary osteoblasts to an nHA paste. Read More

Materials (Basel) 2022 Feb 16;15(4). Epub 2022 Feb 16.

Department of Oral Surgery, Dentistry School, Fluminense Federal University, Niteroi 24020-140, RJ, Brazil.

Sticky bone, a growth factor-enriched bone graft matrix, is a promising autologous material for bone tissue regeneration. However, its production is strongly dependent on manual handling steps. In this sense, a new device was developed to simplify the confection of the sticky bone, named Sticky Bone Preparation Device (SBPD). Read More

Dent J (Basel) 2022 Feb 16;10(2). Epub 2022 Feb 16.

Department of Periodontology, School for Health Sciences, Witten/Herdecke UniversityAlfred-Herrhausen-Str. 45, 58448 Witten, Germany.

Background: The maintenance of ridge volume following tooth extraction has gained more importance in the last few years. This clinical study aimed to assess the impact of autologous dentin particles mixed with injectable platelet-rich fibrin (i-PRF) on a sticky tooth mixture for socket preservation in terms of consecutive need for horizontal guided bone regeneration and histological findings.

Methods: Eight extraction sockets in seven patients were included in this study. Read More

J Orthop Translat 2022 Mar 3;33:13-23. Epub 2022 Feb 3.

Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory (No BZ0128), Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, 100853, China.

Background: /Objective: The treatment of bone defect has always been a difficult problem in orthopedic clinic. The search for alternative biodegradable implants is a hot topic. The development of biodegradable magnesium scaffolds for the treatment of bone defects has long been a goal of the public. Read More

Tissue Eng Part C Methods 2022 03;28(3):127-135

Department of Oral and Maxillofacial Surgery, Peking University Hospital of Stomatology, Beijing, China.

Alveolar cleft repair is a key step in multiple disciplinary treatment for patients with cleft lip/and palate. Although autologous bone grafting has been used worldwide over the past half century, alternative advanced techniques, such as the use of bone substitutes and guided tissue regeneration, have shown their great potentials and have been recommended by a growing number of physicians and surgeons. The employment of new therapeutic approaches and devices in clinical routine requires tremendous experimental efforts and appropriate animal models with similar sizes and sites of deformity to that of human both anatomically and physiologically. Read More

Ann Med 2022 Dec;54(1):565-577

Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Guangxi Collaborative Innovation Center for Biomedicine, Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background: A meta-analysis of eligible studies was performed to evaluate the effectiveness of bone substitute materials (BSMs) in opening wedge high tibial osteotomy (OWHTO) for knee osteoarthritis.

Methods: A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). A comprehensive literature search was performed, and studies comparing BSM with bone graft (BG) and without bone graft (WG) were included. Read More

Materials (Basel) 2022 Jan 31;15(3). Epub 2022 Jan 31.

Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.

Background: For decades, regenerative medicine and dentistry have been improved with new therapies and innovative clinical protocols. The aim of the present investigation was to evaluate through a critical review the recent innovations in the field of bone regeneration with a focus on the healing potentials and clinical protocols of bone substitutes combined with engineered constructs, growth factors and photobiomodulation applications.

Methods: A Boolean systematic search was conducted by PubMed/Medline, PubMed/Central, Web of Science and Google scholar databases according to the PRISMA guidelines. Read More

J Biomed Mater Res B Appl Biomater 2022 Jul 13;110(7):1724-1749. Epub 2022 Feb 13.

Department of Biomedical Engineering, General Sir John Kotelawala Defense University, Ratmalana, Sri Lanka.

Over the past few decades, the field of biomaterials concerning bone tissue engineering has gained a significant amount of interest. This has led to new biomaterials to be used as bone substitute materials. Despite the rapid increase in the types and forms of bone substitutes, a comprehensive classification encompassing all types of bone graft materials that have so far been developed and evaluated is lacking. Read More

Clin Oral Implants Res 2022 Apr 16;33(4):433-440. Epub 2022 Feb 16.

Department of Periodontology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Aims: The purpose of this study was to evaluate the accuracy of bone-level assessments using either cone-beam computed tomography (CBCT), intra-oral peri-apical (PA) radiographs or histology following reconstructive treatment of experimental peri-implantitis.

Materials And Methods: Six Labrador dogs were used. Experimental peri-implantitis was induced 3 months after implant placement. Read More

Regen Ther 2022 Mar 31;19:9-23. Epub 2021 Dec 31.

Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang 050051, PR China.

For decades, researches have concentrated on the mechanical properties, biodegradation, and biocompatibility of implants used in the therapy of large size bone defect. studies demonstrate that bioabsorbable bone substitute materials can reduce the risk of common symptoms such as inflammation and osteonecrosis caused by bio-inert materials after long-term implantation. Several organic, inorganic, and composite materials have been approved for clinical application, based on their unique characteristics and advantages. Read More