1,288,364 results match your criteria Bone & joint research[Journal]


KRAS mutations in brown tumor of the jaws in hyperparathyroidism.

J Oral Pathol Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Pathology, Institute of Biological Science, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Background: Brown tumors are giant cell-rich lesions that result from abnormal bone metabolism in hyperparathyroidism, one of the most common endocrine disorders worldwide. Brown tumors occasionally affect the jaws and, despite well-known clinical and microscopic features, their molecular pathogenesis remains unclear. We investigated the presence of pathogenic activating mutations in TRPV4, FGFR1 and KRAS in a cohort of brown tumors since these have recently been reported in giant-cell lesions of the jaws and non-ossifying fibromas of the bones (FGFR1 and KRAS), which are histologic mimics of brown tumors. Read More

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http://dx.doi.org/10.1111/jop.13048DOI Listing

[Osteoporosis in the geriatric population].

Dtsch Med Wochenschr 2020 Jun 3;145(11):728-732. Epub 2020 Jun 3.

Bereich Endokrinologie/Diabetes/Metabolische Knochenerkrankungen, Medizinische Klinik III & UniversitätsCentrum für Gesundes Altern (UCGA), Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden.

The global prevalence of osteoporotic fractures and the socioeconomic burden is increasing with aging of the population. Frailty, sarcopenia, malnutrition and a propensity to falls are contributing to osteoporotic fractures in old age with an estimated 750 000 fragility fractures per year in Germany. Despite this increasing number of fractures, osteoporosis remains underdiagnosed and undertreated in the geriatric population. Read More

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http://dx.doi.org/10.1055/a-1036-2701DOI Listing

Temperature-programmable and enzymatically solidifiable gelatin-based bioinks enable facile extrusion bioprinting.

Biofabrication 2020 Jun 3. Epub 2020 Jun 3.

Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen, CHINA.

The development of exceptional bioinks with excellent printability, high fidelity, and excellent cell viability maintenance for extrusion bioprinting remains a major challenge. Gelatin is an ideal candidate bioink due to its biocompatibility, biodegradability, and non-immunogenicity. However, its inherently low viscosity and unstable physical gelation under physiological conditions make it unsuitable for direct extrusion bioprinting of tissue-like gelatin constructs with high fidelity. Read More

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http://dx.doi.org/10.1088/1758-5090/ab9906DOI Listing

Circulating cells and exosomes in acute myelogenous leukemia and their role in disease progression and survival.

Clin Immunol 2020 May 31:108489. Epub 2020 May 31.

Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Acute myelogenous leukemia (AML) is an aggressive hematological malignancy associated with high rates of mortality. This incidence is due to the complexity in which the AML cells interact with other healthy human cells. These phenomena create an environment that favors the expansion of leukemic cells, which will affect the patient's prognosis. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108489DOI Listing

The antimicrobial peptide tilapia piscidin 3 induces mitochondria-modulated intrinsic apoptosis of osteosarcoma cells.

Biochem Pharmacol 2020 May 31:114064. Epub 2020 May 31.

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan; Center for Neuroscience, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. Electronic address:

Osteosarcoma (OS) is the most common solid tumor of the bone that most often affects adolescents. The introduction of chemotherapy for the treatment of OS has largely improved the survival rates of patients with localized tumors. However, the 5-year survival rate of OS patients with relapsed or metastatic disease is only 10 to 20%. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114064DOI Listing

N-acetylcysteine differentially regulates the populations of bone marrow and circulating endothelial progenitor cells in mice with limb ischemia.

Eur J Pharmacol 2020 May 31:173233. Epub 2020 May 31.

Center for Precision Medicine and Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO, USA. Electronic address:

Endothelial progenitor cells (EPCs) are important to tissue repair and regeneration especially after ischemic injury, and very heterogeneous in phenotypes and biological features. Reactive oxygen species are involved in regulating EPC number and function. N-acetylcysteine (NAC) inhibits ischemia-induced reactive oxygen species formation and promotes ischemic limb recovery. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173233DOI Listing

Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.

N Engl J Med 2020 Jun;382(23):2207-2219

From the Departments of Pediatric and Adolescent Oncology (V.M.-C., C.P.) and Clinical Research (G.V.), INSERM Unité 1015 (V.M.-C.), and the Unit of Biostatistics and Epidemiology and INSERM Unité 1018 (A.A.), Gustave Roussy, Université Paris-Saclay, Villejuif, France; the Department of Pediatric Hematology and Oncology, University of Padua, Padua, Italy (M.P.); the Department of Paediatric Haematology, Oncology, and Palliative Care, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge (G.A.A.B.), Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham (K.W.), and the Department of Histopathology, Royal Marsden NHS Foundation Trust, London (A.W.) - all in the United Kingdom; the Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles (D.A.B.); the Department of Pediatric Hematology and Oncology, University of Valencia, Valencia, Spain (R.F.D.); the Division of Haematology-Oncology, Hospital for Sick Children, Toronto (S.A.); the Department of Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, Belgium (A.U.); the Center for Cancer and Immunology Research, Children's National Health System and George Washington University, Washington, DC (C.M.B.); Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands (J.Z.); the Department of Pediatric Hematology and Oncology, Semmelweis University, Budapest, Hungary (M.C.); the Department of Pediatric Bone Marrow Transplantation, Oncology, and Hematology, Wroclaw Medical University, Wroclaw, Poland (B.K.); the Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong (A.K.C.); the Department of Pathology, University of Utah, Salt Lake City (R.R.M.); Children's Hospital of Philadelphia, Philadelphia (P.C.A.); and the National Cancer Institute, Center for Global Health, Rockville, MD (T.G.G.).

Background: Rituximab added to chemotherapy prolongs survival among adults with B-cell cancer. Data on its efficacy and safety in children with high-grade, mature B-cell non-Hodgkin's lymphoma are limited.

Methods: We conducted an open-label, international, randomized, phase 3 trial involving patients younger than 18 years of age with high-risk, mature B-cell non-Hodgkin's lymphoma (stage III with an elevated lactate dehydrogenase level or stage IV) or acute leukemia to compare the addition of six doses of rituximab to standard lymphomes malins B (LMB) chemotherapy with standard LMB chemotherapy alone. Read More

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http://dx.doi.org/10.1056/NEJMoa1915315DOI Listing

Application of mesenchymal stem cell exosomes and their drug-loading systems in acute liver failure.

J Cell Mol Med 2020 Jun 3. Epub 2020 Jun 3.

Office of Clinical Trial of Drug, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.

Stem cell exosomes are nanoscale membrane vesicles released from stem cells of various origins that can regulate signal transduction pathways between liver cells, and their functions in intercellular communication have been recognized. Due to their natural substance transport properties and excellent biocompatibility, exosomes can also be used as drug carriers to release a variety of substances, which has great prospects in the treatment of critical and incurable diseases. Different types of stem cell exosomes have been used to study liver diseases. Read More

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http://dx.doi.org/10.1111/jcmm.15290DOI Listing

Validation of PATHFx 2.0-an open source tool for estimating survival in patients undergoing pathologic fracture fixation.

J Orthop Res 2020 Jun 3. Epub 2020 Jun 3.

Orthopaedics, USU-Walter Reed Department of Surgery, 4301 Jones Bridge Rd, Bethesda, MD, 20814, USA.

Treatment decisions in patients with metastatic bone disease rely on accurate survival estimation. We developed the original PATHFx models using expensive, proprietary software and now seek to provide a more cost effective solution. Using open source machine learning software to create PATHFx version 2. Read More

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http://dx.doi.org/10.1002/jor.24763DOI Listing

Denosumab for the Prevention of Falls in Older People: We Need More Evidence.

J Bone Miner Res 2020 Jun 3. Epub 2020 Jun 3.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1002/jbmr.4051DOI Listing

T2* mapping in an equine articular groove model - visualizing changes in collagen orientation.

J Orthop Res 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.

T2* mapping is promising for the evaluation of articular cartilage collagen. In this work, a groove model in a large animal is used as a model for post-traumatic arthritis. We hypothesized that T2* mapping could be employed to differentiate between healthy and (subtly) damaged cartilage. Read More

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http://dx.doi.org/10.1002/jor.24764DOI Listing

Supraclavicular Artery Island Flap: Critical Appraisal and Comparison to Alternate Reconstruction.

Laryngoscope 2020 Jun 3. Epub 2020 Jun 3.

USC Caruso Department of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, California, U.S.A.

Objectives/hypothesis: The supraclavicular artery island (SAI) flap may be a good option for selected head and neck reconstruction due to its reliability, ease of harvest, and favorable color match. The objective of this study was to examine the rates of complications for the SAI flap in head and neck oncologic reconstruction, with examination of risk factors and comparisons to alternative flaps often considered the gold-standard soft-tissue flaps for head and neck reconstruction: the pectoralis myocutaneous (PMC), radial forearm free flap (RFFF), and anterolateral thigh (ALT) flaps.

Study Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1002/lary.28706DOI Listing

Clinicopathological characteristics and survival of malignant fibrous histiocytoma of the bone: A population-based study using the SEER database.

PLoS One 2020 3;15(6):e0232466. Epub 2020 Jun 3.

Department of Orthopedics, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, People Republic of China.

Malignant fibrous histiocytoma of the bone (MFH-B) is an extremely rare and aggressive malignancy. The clinicopathological characteristics and prognosis of patients with MFH-B have not been defined. We conducted a retrospective study using the data of all MFH-B patients from the Surveillance, Epidemiology and End Results (SEER) database between 1975 and 2016. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232466PLOS

Assessment of inflammatory jaw pathologies using bone SPECT-CT maximum standardized uptake value.

Dentomaxillofac Radiol 2020 Jun 3:20200043. Epub 2020 Jun 3.

Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.

Objective: To investigate the assessment of inflammatory jaw pathologies using bone single-photon emission computed tomography-computed tomography (SPECT-CT) maximum standardized uptake value (SUV).

Methods: Forty-four patients with inflammatory jaw pathologies (seven chronic osteomyelitis, 8 osteoradionecrosisand 29 medication-related osteonecrosis of the jaw (MRONJ)) underwent SPECT-CT at 4 h after injection of Tc hydroxymethylene diphosphonate. The SPECT-CT parameters SUV of the inflammatory jaw pathologies were analyzed. Read More

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http://dx.doi.org/10.1259/dmfr.20200043DOI Listing

Use of a radiopaque localizer grid and methylene blue staining as an aid to reduce radiation exposure.

Authors:
Bo He Guoxin Nan

Minim Invasive Ther Allied Technol 2020 Jun 3:1-5. Epub 2020 Jun 3.

Department II of Orthopaedics, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, the Children's Hospital of Chongqing Medical University, Chongqing, China.

: Localization of small femur lesions for resection can be challenging and may be associated with the need for significant fluoroscopic imaging and tissue dissection. This study was performed to evaluate the use of a radiopaque localizer grid along with methylene blue staining for resection of small femur lesions in children, and to determine the effectiveness of this effectiveness at reducing radiation exposure and tissue injury.: A radiopaque localizer grid was used to identify the body surface site of bone lesions, and then 0. Read More

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http://dx.doi.org/10.1080/13645706.2020.1771374DOI Listing

Chondrosesamoidean ligament enthesopathy: prevalence and findings in a population of lame horses imaged with positron emission tomography.

Equine Vet J 2020 Jun 3. Epub 2020 Jun 3.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.

Background: Increased 18F-Sodium Fluoride (18F-NaF) uptake at the chondrosesamoidean ligament (ChSL) attachment on the distal phalanx was identified in an exploratory positron emission tomography (PET) study. The prevalence and significance of this lesion has not been previously investigated.

Objectives: The goal of this study was to assess the prevalence of this lesion, its association with other imaging findings and with clinical signs. Read More

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http://dx.doi.org/10.1111/evj.13299DOI Listing

Electron density and effective atomic number estimation in a maximum a posteriori framework for dual-energy computed tomography.

Med Phys 2020 Jun 3. Epub 2020 Jun 3.

Département de physique, Université de Montréal, Complexe des sciences, 1375 Avenue Thérèse-Lavoie-Roux, Montréal, Québec, H2V 0B3, Canada.

Purpose: The stoichiometric calibration method for dual-energy CT (DECT) proposed by Bourque et al. (Phys. Med. Read More

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http://dx.doi.org/10.1002/mp.14309DOI Listing

Full Gait Cycle Knee Kinematics of Healthy Adults Measured Using Biplane Radiography.

J Biomech Eng 2020 Jun 3. Epub 2020 Jun 3.

Biodynamics Lab, Department of Orthopaedic Surgery, University of Pittsburgh, 3820 South Water Street, Pittsburgh, PA 15203, USA.

A dataset of knee kinematics in healthy, uninjured adults is needed to serve as a reference for comparison when evaluating the effects of injury, surgery, rehabilitation, and age. Most currently available datasets that characterize healthy knee kinematics were developed using conventional motion analysis, known to suffer from skin motion artifact. More accurate kinematics, obtained from bone pins or biplane radiography, have been reported for datasets ranging in size from 5 to 15 knees. Read More

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http://dx.doi.org/10.1115/1.4047419DOI Listing

Facial profile changes due to bone cement graft to manage the hyperactive muscles of the gingival smile.

Dental Press J Orthod 2020 Mar 29;25(2):44-51. Epub 2020 May 29.

Divisão de Endodontia, Faculdade de Odontologia, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Objective: To evaluate facial profile changes promoted by polymethyl methacrylate (PMMA) cement graft to reduce excessive gingival display due to hyperactivity of the elevator muscles of the upper lip during smiling.

Methods: Eleven patients (all females, age range: 20 to 43 years) presenting gingival smile that were treated with PMMA cement grafts in a private clinic were selected for this retrospective study. Three angular and ten linear cephalometric facial profile measurements were performed preoperatively (baseline, T1) and at least 6 months postoperatively (T2). Read More

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http://dx.doi.org/10.1590/2177-6709.25.2.044-051.oarDOI Listing

Management of skeletal Class III with facial asymmetry using skeletal anchorage: 4-year follow-up.

Dental Press J Orthod 2020 Mar 29;25(2). Epub 2020 May 29.

Department of Orthodontics and Dentofacial Orthopaedics, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Introduction: Skeletal Class III malocclusion with asymmetry is one of the most difficult problems to correct in orthodontics. A functional shift of the mandible in growing patients may occur accompanying a Class III, due to constricted maxillary arch and occlusal interferences. Studies have indicated that posterior unilateral crossbite develops early and has a low rate of spontaneous correction. Read More

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http://dx.doi.org/10.1590/2177-6709.25.2.24.e1-9.onlDOI Listing

Extensive orthodontically induced dental resorption: What to do?

Dental Press J Orthod 2020 Mar 29;25(2):18-23. Epub 2020 May 29.

Faculdade de Odontologia de Bauru, Universidade de São Paulo, Bauru, SP, Brazil.

If essential care is thorough, teeth with extensive orthodontically induced dental resorption can have the same endurance as normal teeth. These teeth are subjected to the same disturbances as normal ones, such as dental trauma, dental caries and periodontal disease, all of which are independent of severe dental resorption. Orthodontic retreatments of teeth presenting with extensive orthodontically induced dental resorption must take into consideration that these roots are shorter in length, therefore, they are more prone to root resorption. Read More

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http://dx.doi.org/10.1590/2177-6709.25.2.018-023.oinDOI Listing

Latissimus dorsi transfer using bone block technique to restore active external rotation in reversed total shoulder arthroplasty.

Acta Orthop Belg 2020 Mar;86(1):166-174

The aim was to compare the outcome of a reversed shoulder arthroplasty with a latissiumus dorsi transfer without (LD-BB) or with bone block (LD+BB) in patients with rotator cuff-deficient shoulders and combined loss of active elevation and external rotation. Postoperative patients with LD+BB were not immobilized compared to 6 weeks of immobilization in patients with LD-BB. Clinical outcome was evaluated using the Constant Score, ADLER score and satisfaction rate. Read More

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