1,229,043 results match your criteria Bone & joint research[Journal]


Total and Regional Body Composition of NCAA Division I Collegiate Baseball Athletes.

Int J Sports Med 2019 Apr 23. Epub 2019 Apr 23.

School of Kinesiology, University of Minnesota, Minneapolis, United States.

This study's purpose was to evaluate total, regional, and throwing versus non-throwing arm body composition measurements between various positions of NCAA Division I male baseball players using dual X-ray absorptiometry (DXA). Two hundred and one collegiate baseball athletes were measured using DXA. Visceral adipose tissue (VAT), total and regional fat mass (FM), lean mass (LM), and bone mineral density (BMD) were measured. Read More

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http://dx.doi.org/10.1055/a-0881-2905DOI Listing

Twisting the bone marrow stem cell niche.

Haematologica 2018 Dec 30;103(12):1937-1939. Epub 2018 Nov 30.

Division of Experimental Hematology and Cancer Biology, Cancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati.

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http://dx.doi.org/10.3324/haematol.2018.206029DOI Listing
December 2018

The optimization of sintering treatment on bovine-derived bone grafts for bone regeneration: in vitro and in vivo evaluation.

J Biomed Mater Res B Appl Biomater 2019 Apr 23. Epub 2019 Apr 23.

Department of Prothodontics, The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Modifications of sintering temperature and treatment time of bovine-derived bone grafts affect their physicochemical properties and further influence biological activity. Three different temperature sintered bovine-derived bone grafts: group I (300 °C 3 h), group II (300 °C 3 h plus 530 °C 6 h), and group III (300 °C 3 h plus 1000 °C 2 h) and Bio-Oss® were characterized and then compared in vitro for their effects on bone marrow stromal cells (BMSCs) migration, proliferation, and differentiation as estimated by cell migration assay, Alkaline phosphatase (ALP) activity assay, and Alizarin red staining. Further, the four bone grafts were implanted into the calvarial defects of rabbits to evaluate bone regeneration and graft degradation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.34387
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http://dx.doi.org/10.1002/jbm.b.34387DOI Listing
April 2019
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Graphene Oxide Incorporated Polycaprolactone/Chitosan/Collagen Electrospun Scaffold: Enhanced Osteogenic Properties for Bone Tissue Engineering.

Artif Organs 2019 Apr 23. Epub 2019 Apr 23.

Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.

This in vitro study aimed to evaluate the physicochemical and biological activity of the polycaprolactone/chitosan/collagen scaffolds incorporated with 0, 0.5, 3, and 6 wt% graphene oxide (GO). Using standard tests and MG-63 cells the characteristics of scaffolds were evaluated, and the behavior of osteoblasts were simulated respectively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/aor.13474
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http://dx.doi.org/10.1111/aor.13474DOI Listing
April 2019
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The value of cytoreductive nephrectomy on the survival of metastatic renal carcinoma patients based on the number of site-specific metastases.

PLoS One 2019 23;14(4):e0215861. Epub 2019 Apr 23.

Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: There has been significant uncertainty in the selection of candidates for cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma (mRCC). This report investigates the influence of site-specific metastases (bone, brain, liver, and lung) on the survival benefit of CN.

Methods: Within the Surveillance, Epidemiology and End Results database (2010-2014), 1113 mRCC patients treated with CN (n = 618) or no surgery (NS, n = 495) met the selection criteria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215861PLOS
April 2019
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Effects of tendon injury on uninjured regional tendons in the distal limb: An in-vivo study using an ovine tendinopathy model.

PLoS One 2019 23;14(4):e0215830. Epub 2019 Apr 23.

Raymond Purves Bone and Joint Research Laboratories, The Kolling Institute, Sydney Medical School, University of Sydney, Sydney, Australia.

Following injury to a tendon little is known about potential for pathology to develop in other regional tendons from overloading or altered function. The aim of this study was to investigate the gene expression and histopathological changes that occur 1) within the deep digital flexor tendon (DDFT) after injury to the superficial digital flexor tendon (SDFT) and 2) within the flexor tendons (SDFT and DDFT) after injury to the extensor tendons. Merino wethers [Ovis aries] (n = 18) were divided into three equal groups and underwent either partial transection of the SDFT, complete transection of the extensor tendons or were left as non-operated controls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215830PLOS

Dicer regulates activation of the NLRP3 inflammasome.

PLoS One 2019 23;14(4):e0215689. Epub 2019 Apr 23.

School of Kinesiology and Health Science, Muscle Health Research Centre (MHRC), Faculty of Health, York University, Toronto, ON, Canada.

Inflammation plays a critical role in initiation of adaptive immunity, pathogen clearance and tissue repair. Interleukin (IL)-1β is a potent pro-inflammatory cytokine and therefore its production is tightly regulated: its secretion requires the assembly of a macromolecular protein complex, termed the inflammasome. Aberrant activation of the inflammasome has been linked to debilitating human diseases including chronic inflammatory and autoimmune diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215689PLOS
April 2019
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Activation of the calcium sensing receptor attenuates TRPV6-dependent intestinal calcium absorption.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Plasma calcium (Ca2+) is maintained by amending the release of parathyroid hormone and through direct effects of the Ca2+ sensing receptor (CaSR) in the renal tubule. Combined, these mechanisms alter intestinal Ca2+ absorption by modulating 1,25-dihydroxy vitamin D3 production, bone resorption, and renal Ca2+ excretion. The CaSR is a therapeutic target in the treatment of secondary hyperparathyroidism and hypocalcemia a common complication of calcimimetic therapy. Read More

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http://dx.doi.org/10.1172/jci.insight.128013DOI Listing

Early alterations in stem-like/resident T cells, innate and myeloid cells in the bone marrow in preneoplastic gammopathy.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Preneoplastic lesions carry many of the antigenic targets found in cancer cells but often exhibit prolonged dormancy. Understanding how the host response to premalignancy is maintained and altered during malignant transformation is needed to prevent cancer. In order to understand the immune microenvironment in precursor monoclonal gammopathy of undetermined significance (MGUS) and myeloma, we analyzed bone marrow immune cells from 12 healthy donors and 26 MGUS/myeloma patients by mass cytometry and concurrently profiled transcriptomes of 42,606 single immune cells from these bone marrows. Read More

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http://dx.doi.org/10.1172/jci.insight.127807DOI Listing

COMPARATIVE EFFICACY AND SAFETY OF THREE CURRENT CLINICAL TREATMENTS FOR GIRLS WITH CENTRAL PRECOCIOUS PUBERTY: A NETWORK META-ANALYSIS.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 1Department of Nutrition, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

: The optimal treatment for girls with central precocious puberty (CPP) is unknown. We conducted a network meta-analysis to evaluate the efficacy and safety of existing treatments to provide credible clinical guidelines. We compared gonadotropin-releasing hormone analogue (GnRHa) therapy, GnRHa plus growth hormone (GH) combination therapy, and no-treatment therapy to treat girls with CPP by performing an electronic search for studies in PubMed, Embase, Chinese National Knowledge Infrastructure databases, and Wanfang Data from their inception until 30 September 2018. Read More

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http://journals.aace.com/doi/10.4158/EP-2019-0008
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http://dx.doi.org/10.4158/EP-2019-0008DOI Listing
April 2019
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Mechanically Strong Silica-Silk Fibroin Bioaerogel: A Hybrid Scaffold with Ordered Honeycomb Micromorphology and Multiscale Porosity for Bone Regeneration.

ACS Appl Mater Interfaces 2019 Apr 23. Epub 2019 Apr 23.

Due to the synergic feature of individual components in hybrid (nano)biomaterials, their application in regenerative medicine has drawn a significant attention. Aiming to address all the current challenges of aerogel as a potent scaffold in bone tissue engineering application, we adopted a novel synthesis approach to synergistically improve the pore size regime and mechanical strength in the aerogel. The 3D aerogel scaffold in this study has been synthesized through a versatile one-pot aqueous based sol-gel hybridization/ assembly of organosilane (tetraethylorthosilicate, TEOS) and silk fibroin (SF) biopolymer followed by unidirectional freeze casting the as-prepared hybrid gel and supercritical drying. Read More

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http://dx.doi.org/10.1021/acsami.9b04283DOI Listing

Testing the deconditioning hypothesis of low back pain: A study in 1182 older women.

Eur J Sport Sci 2019 Apr 23:1-7. Epub 2019 Apr 23.

a Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences , Deakin University , Geelong , Australia.

This study assessed the deconditioning hypothesis of low back pain (LBP) by examining physical function in relation to LBP and self-reported physical activity in women. This cross-sectional study recruited a representative population-based sample of females aged greater than 60 years. In total, 1182 women were included in the study and completed questionnaires (physical activity and LBP intensity) and functional testing (countermovement jump, chair rise, gait speed and grip strength). Read More

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http://dx.doi.org/10.1080/17461391.2019.1606942DOI Listing

Agger Nasi Cells Versus Lacrimal Cells and Uncinate Bullae in Cone-Beam Computed Tomography.

Ear Nose Throat J 2019 Apr 23:145561319840836. Epub 2019 Apr 23.

5 Department II of Surgical Clinical Divisions, Faculty of Medicine, "Ovidius" University, Constanţa, Romania.

The maxillary bone's frontal process, lacrimal bone, and ethmoidal labyrinth's uncinate process can each harbor pneumatizations, referred to as agger nasi cells (ANCs), lacrimal cells (LCs), and uncinate bullae (UBs), respectively. Different studies have failed to differentiate ANCs from LCs. We aimed at studying these 3 anatomic sites to establish the anatomical patterns that could be encountered. Read More

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http://dx.doi.org/10.1177/0145561319840836DOI Listing

Opposite alterations of endothelin-1 in lung and pulmonary artery mirror gene expression of bone morphogenetic protein receptor 2 in experimental pulmonary hypertension.

Exp Lung Res 2019 Apr 23:1-12. Epub 2019 Apr 23.

a Department of Pharmacology and Toxicology, Faculty of Pharmacy , Comenius University in Bratislava , Bratislava , Slovakia.

Aim Of The Study: Endothelin-1 (ET-1) overexpression was suggested to play a role in pulmonary hypertension (PH). However, the roles of ET-1 in early stages of PH remain unexplored. We examined the expression of ET-1 and relevant disease progression markers in the pulmonary artery and the lungs during the development of PH induced by monocrotaline (MCT). Read More

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https://www.tandfonline.com/doi/full/10.1080/01902148.2019.1
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http://dx.doi.org/10.1080/01902148.2019.1605426DOI Listing
April 2019
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Sustained-release of sclerostin single-chain antibody fragments using Poly (lactic-co-glycolic acid) microspheres for osteoporotic fracture repair.

J Biomed Mater Res A 2019 Apr 23. Epub 2019 Apr 23.

Department of Orthopedics, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, Peking University Ninth School of Clinical Medicine, 100038 China.

Osteoporotic fracture is one of the most common bone diseases in middle and old age, as the most serious consequence of osteoporosis. Sclerostin single-chain antibody fragments (SCL-scFv) has been proven to promote bone formation by binding to scleroprotein, a natural antagonist of the Wnt pathway, but it is difficult to rule alone due to the weak permeability and immunogenicity. Herein, we prepared poly(lactic-co-glycolic acid) (PLGA) microspheres as a sustained-release vehicle to prolong the activity of SCL-scFv. Read More

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http://dx.doi.org/10.1002/jbm.a.36704DOI Listing

Survival analysis in dogs with urinary transitional cell carcinoma that underwent whole-body computed tomography at diagnosis.

Vet Comp Oncol 2019 Apr 23. Epub 2019 Apr 23.

Laboratory of Veterinary Clinical Oncology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.

This retrospective study aimed to evaluate factors associated with survival and to compare characteristics between tumour localizations in dogs with urinary transitional cell carcinoma (TCC) that underwent whole-body computed tomography (CT) at diagnosis. Dogs with histologically confirmed TCC that received medical therapy between 2010 and 2017 were included; dogs that underwent surgery or radiotherapy for the primary tumour were excluded. According to the CT findings, primary tumour localization (classified into the Bladder, Urethra, and Bladder & Urethra groups), prostate involvement, iliosacral lymphadenomegaly, sternal lymphadenomegaly, and metastasis to the bone and lung were evaluated for survival analysis. Read More

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http://dx.doi.org/10.1111/vco.12483DOI Listing

Prolonged survival after craniectomy with skull reconstruction and adjuvant definitive radiation therapy in three dogs with multilobular osteochondrosarcoma.

Vet Radiol Ultrasound 2019 Apr 22. Epub 2019 Apr 22.

Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts.

Multilobular osteochondrosarcoma is an uncommon canine tumor but presents a treatment challenge when arising on the skull. This retrospective case series study aimed to describe outcome of a multimodality treatment approach involving aggressive surgical resection and adjuvant definitive radiation therapy in a group of dogs with multilobular osteochondrosarcoma of the calvarium. Clinical, imaging, treatment, and outcome data were collected from retrospective review of medical records. Read More

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http://dx.doi.org/10.1111/vru.12750DOI Listing

POEMS Syndrome: update on diagnosis, risk-stratification, and management.

Am J Hematol 2019 Apr 22. Epub 2019 Apr 22.

Professor of Medicine and Laboratory Medicine, Mayo Clnic.

Disease Overview: POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Read More

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http://dx.doi.org/10.1002/ajh.25495DOI Listing

Biology and therapy of multiple myeloma.

Med J Aust 2019 Apr 23. Epub 2019 Apr 23.

Royal Prince Alfred Hospital, Sydney, NSW.

Genetic sequencing of the myeloma genome has not revealed a specific disease-determining genetic alteration. Multiple disease subclones exist at diagnosis and vary in clinical importance with time and drug sensitivity. New diagnostic criteria have identified indications for early introduction of therapy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50129
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http://dx.doi.org/10.5694/mja2.50129DOI Listing
April 2019
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Infected Cemento-Osseous Dysplasia: Analysis of 66 Cases and Literature Review.

Head Neck Pathol 2019 Apr 22. Epub 2019 Apr 22.

Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Room 3202 D. Pampulha, Belo Horizonte, MG, CEP: 31.270-901, Brazil.

The aim of this study was to describe a series with 66 cases of infected cemento-osseous dysplasia (COD) and to discuss the demographic distribution, clinicoradiographic features and treatment of this condition. A study looking back on the diagnoses made at a single Brazilian centre within a 28-year timeframe was performed. A literature review with searches across five databases was also conducted to identify reports on osteomyelitis/infected COD. Read More

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http://link.springer.com/10.1007/s12105-019-01037-x
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http://dx.doi.org/10.1007/s12105-019-01037-xDOI Listing
April 2019
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A Region-Based Deep Level Set Formulation for Vertebral Bone Segmentation of Osteoporotic Fractures.

J Digit Imaging 2019 Apr 22. Epub 2019 Apr 22.

POF's Hospital, Wah Cantt, Pakistan.

Accurate segmentation of the vertebrae from medical images plays an important role in computer-aided diagnoses (CADs). It provides an initial and early diagnosis of various vertebral abnormalities to doctors and radiologists. Vertebrae segmentation is very important but difficult task in medical imaging due to low-contrast imaging and noise. Read More

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http://dx.doi.org/10.1007/s10278-019-00216-0DOI Listing

A computer aided diagnosis system for measurement of mandibular cortical thickness on dental panoramic radiographs in prediction of women with low bone mineral density.

J Med Syst 2019 Apr 22;43(6):148. Epub 2019 Apr 22.

Department of Chemistry, C. Kandasamy Naidu college for women, Cuddalore, 607 001, India.

Osteoporosis detection at earlier stages can enhance the life span of an elderly individual. The aim of the study is to perform semi-automated measurement of mandibular cortical thickness (MCT) on a dental panoramic radiograph (DPR) and thereby to predict the risk of low BMD among the studied population. The study involved 76 women (mean age: 57. Read More

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http://dx.doi.org/10.1007/s10916-019-1268-7DOI Listing

Case report: chronic inflammatory ulcer and osteoradionecrosis of the skull following radiotherapy in early childhood.

Oral Maxillofac Surg 2019 Apr 23. Epub 2019 Apr 23.

Department of Oral and Maxillofacial Surgery and Plastic Operations, Central Medical Centre Bremen, Bremen, Germany.

Introduction: Chronic inflammatory diseases of the skin are the most common differential diagnosis of tumorous lesions of the craniofacial region. Detailed information about a patient's medical history is important for the clinical diagnosis of such cases. Previous radiotherapy should be taken into account, especially in cases of chronic dermatitis, since complications include osteoradionecrois of the adjacent bone strucutres with surrounding inflammation. Read More

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http://dx.doi.org/10.1007/s10006-019-00752-7DOI Listing

Human behavior and Homo-mammal interactions at the first European peopling: new evidence from the Pirro Nord site (Apricena, Southern Italy).

Naturwissenschaften 2019 Apr 22;106(5-6):16. Epub 2019 Apr 22.

Dipartimento di Studi Umanistici, Università degli Studi di Ferrara, Ferrara, Italy.

Recent functional and zooarchaeological studies conducted on the archeological finds of Pirro Nord (PN13) produced new, reliable data on early European hominid subsistence activities. The age of the site is estimated to be ~ 1.3-1. Read More

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http://dx.doi.org/10.1007/s00114-019-1610-4DOI Listing

Electrospun polycaprolactone/hydroxyapatite/ZnO nanofibers as potential biomaterials for bone tissue regeneration.

J Mater Sci Mater Med 2019 Apr 22;30(5):51. Epub 2019 Apr 22.

Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Pune, 411008, India.

Fabricating a bioartificial bone graft possessing structural, mechanical and biological properties mimicking the real bone matrix is a major challenge in bone tissue engineering. Moreover, the developed materials are prone to microbial invasion leading to biomaterial centered infections which might limit their clinical translation. In the present study, biomimetic nanofibrous scaffolds of Poly ɛ-caprolactone (PCL)/nano-hydroxyapatite (nHA) were electrospun with 1wt%, 5wt%, 10wt%, 15wt% and 30wt% of zinc oxide (ZnO) nanoparticles in order to understand the optimal concentration range of (ZnO) nanoparticles balancing both biocompatibility and osteoregeneration. Read More

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http://link.springer.com/10.1007/s10856-019-6255-5
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http://dx.doi.org/10.1007/s10856-019-6255-5DOI Listing
April 2019
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Regional Changes in Density and Microarchitecture in the Ultradistal Tibia of Female Recruits After U.S. Army Basic Combat Training.

Calcif Tissue Int 2019 Apr 22. Epub 2019 Apr 22.

Department of Defense Biotechnology High Performance Computing Software Applications Institute, Fort Detrick, MD, USA.

Musculoskeletal injuries, such as stress fracture, are responsible for over 10-million lost-duty days among U.S. Army Soldiers. Read More

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http://link.springer.com/10.1007/s00223-019-00548-7
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http://dx.doi.org/10.1007/s00223-019-00548-7DOI Listing
April 2019
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Factors associated with gait outcomes in patients with traumatic lumbosacral plexus injuries.

Eur J Trauma Emerg Surg 2019 Apr 22. Epub 2019 Apr 22.

Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: Lumbosacral plexus injuries usually occur in patients with severe, multiple traumas requiring intensive care, affecting gait function. The purpose of the present study was to identify the initial factors associated with gait outcome in lumbosacral plexus injuries caused by traumas.

Methods: We retrospectively identified 664 patients with pelvic fractures caused by trauma between 2006 and 2017. Read More

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http://dx.doi.org/10.1007/s00068-019-01137-xDOI Listing

Single-fraction Stereotactic Body Radiation Therapy versus Conventionally Fractionated Radiation Therapy for the Treatment of Prostate Cancer Bone Metastases.

Adv Radiat Oncol 2019 Apr-Jun;4(2):314-322. Epub 2019 Feb 19.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Purpose: This study aimed to compare outcomes of patients with prostate cancer with bone metastases treated with stereotactic body radiation therapy (SBRT) versus conventionally fractionated radiation therapy (CFRT).

Methods And Materials: An institutional, retrospective review was conducted of patients with prostate cancer receiving radiation therapy to bone metastases. In-field failure (IFF) was the primary outcome of the study, and distant failure (DF) and biochemical failure (BF) were secondary outcomes. Read More

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http://dx.doi.org/10.1016/j.adro.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460234PMC
February 2019

Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study.

Biomed Res Int 2019 18;2019:8961409. Epub 2019 Mar 18.

Department of Oral Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, China.

Polycaprolactone (PCL) has attracted great attention for bone regeneration attributed to its cost-efficiency, high toughness, and good processability. However, the relatively low elastic modulus, hydrophobic nature, and insufficient bioactivity of pure PCL limited its wider application for bone regeneration. In the present study, the effects of the addition of boron containing bioactive glass (B-BG) materials on the mechanical properties and biological performance of PCL polymer were investigated with different B-BG contents (0, 10, 20, 30, and 40 wt. Read More

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http://dx.doi.org/10.1155/2019/8961409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442456PMC

Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies.

Biomed Res Int 2019 18;2019:8345309. Epub 2019 Mar 18.

Clinic for Maxillofacial Surgery, School of Dental Medicine, University of Belgrade, Serbia.

This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Read More

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https://www.hindawi.com/journals/bmri/2019/8345309/
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http://dx.doi.org/10.1155/2019/8345309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442486PMC
March 2019
1 Read

The Effect of Mesenchymal Stem Cells on the Expression of IDO and Qa2 Molecules in Dendritic Cells.

Adv Pharm Bull 2019 Feb 2;9(1):56-63. Epub 2019 Feb 2.

Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Mesenchymal stem cells (MSCs) have been shown to reduce the activity of immune cells, including dendritic cells (DCs). But the exact mechanism of mesenchymal inhibition of DCs is still unknown. In this study, the effect of mesenchymal cells on the expression of indoleamine dioxygenase (IDO) and Qa2 molecules in DCs was evaluated. Read More

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http://dx.doi.org/10.15171/apb.2019.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468229PMC
February 2019

Pathology and epidemiology of nasopulmonary acariasis ( sp.) in southern sea otters ().

Int J Parasitol Parasites Wildl 2019 Aug 24;9:60-67. Epub 2019 Mar 24.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Ave., Davis, CA, 95616, USA.

sp. nasal mites infest harbor seals and southern sea otters in California, but little is known about the pathophysiology of these infestations, or risk factors for exposure. To investigate these questions, a retrospective case-control study was performed using necropsy data from 70 mite-infested sea otters, and 144 non-infested controls. Read More

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http://dx.doi.org/10.1016/j.ijppaw.2019.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463542PMC

Plasma levels of Semaphorin 4D are decreased by adjuvant tamoxifen but not aromatase inhibitor therapy in breast cancer patients.

J Bone Oncol 2019 Jun 4;16:100237. Epub 2019 Apr 4.

Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine III, TU Dresden Medical Center, Fetscherstraße 74, D-01307 Dresden, Germany.

Background: Semaphorin 4D (Sema4D) is a glycoprotein that inhibits bone formation and has been associated with cancer progression and the occurrence of bone metastases. Recently, Sema4D expression has been linked to estrogen signaling in breast cancer. Endocrine therapies like tamoxifen and aromatase inhibitors (AI) are a standard therapeutic approach in hormone receptor positive breast cancers. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461588PMC

Role of autophagy in osteosarcoma.

J Bone Oncol 2019 Jun 3;16:100235. Epub 2019 Apr 3.

UMR E-4320 TIRO-MATOs CEA/DRF/BIAM, Faculté de Médecine Nice, Université Nice Sophia Antipolis, Avenue de Valombrose, 06107 Nice Cédex 2, France.

Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. It is a highly aggressive tumor with a tendency to spread to the lungs, which are the most common site of metastasis. Advanced osteosarcoma patients with metastasis share a poor prognosis. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460301PMC

Pelvic reconstruction following resection of tumour involving the whole ilium and acetabulum.

J Bone Oncol 2019 Jun 27;16:100234. Epub 2019 Mar 27.

Bone and Soft Tissue Tumour Centre, People's Hospital of Beijing University, Beijing 100044, China.

Background: Functional reconstruction following resection of pelvic tumours with the ileum and the acetabulum involvement is challenging and demanding. The aim of this study was to evaluate the results of these patients receiving pelvic reconstruction with a femoral head autograft plus a hemipelvic prosthesis.

Methods: Eighteen patients receiving pelvic reconstruction with a femoral head autograft plus a hemipelvic prosthesis following resection of pelvic tumours involving the whole ileum and the acetabulum were included in this study from April 2006 to June 2014. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460299PMC

Long noncoding RNA UCA1 promotes osteosarcoma metastasis through CREB1-mediated epithelial-mesenchymal transition and activating PI3K/AKT/mTOR pathway.

J Bone Oncol 2019 Jun 1;16:100228. Epub 2019 Mar 1.

Department of Orthopedics, No. 215 Hospital of Shannxi Nuclear Industry, Xianyang, Shaanxi 712000, PR China.

Increasing evidences have demonstrated that Long noncoding RNAs (lncRNAs) are key regulatory RNAs that participate in multiple biological processes. LncRNA urothelial carcinoma-associated 1 () is a newly identified lncRNA and functions as a regulator of growth in several cancers. However, the biological function and molecular mechanism of in the metastasis of osteosarcoma remain unclear. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463206PMC

Fever and Erythema are Specific Findings in Detecting Infection Following Total Knee Arthroplasty.

J Bone Jt Infect 2019 16;4(2):92-98. Epub 2019 Mar 16.

The Rothman Institute at Thomas Jefferson University, Philadelphia, PA 19107.

Current diagnostic modalities are based almost exclusively on laboratory findings and the role of clinical presentation remains unknown. The purpose of this study was to examine the diagnostic value of clinical presentation in detecting periprosthetic joint infection (PJI). This study evaluated 279 patients undergoing revision surgery for failed total knee arthroplasty (TKA) between 2001-2016. Read More

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http://dx.doi.org/10.7150/jbji.30088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470654PMC

Intraoperative Transfusion of Red Blood Cell Units Stored >14 Days is Associated with an Increased Risk of Prosthetic Joint Infection.

J Bone Jt Infect 2019 16;4(2):85-91. Epub 2019 Mar 16.

Service of Infectious Diseases. Hospital Clinic of Barcelona, University of Barcelona, IDIBAPS. Barcelona Spain.

The aim of the present study was to evaluate the association between prosthetic joint infection (PJI) after joint arthroplasty and the length of red blood cell (RBC) storage, timing of RBC transfusion, and the number of RBC units transfused. All patients who underwent a primary or revision joint artrhoplasty between January 2000 and December 2012 were retrospectively reviewed. For this study, only patients who received RBC transfusions during the day of the surgery (early transfusion group) or within the first 4 days after surgery (late transfusion group) were included. Read More

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http://dx.doi.org/10.7150/jbji.30001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470657PMC

Radiographic and Histological Analysis of a Synthetic Bone Graft Substitute Eluting Gentamicin in the Treatment of Chronic Osteomyelitis.

J Bone Jt Infect 2019 16;4(2):76-84. Epub 2019 Mar 16.

Consultant in Limb Reconstruction Surgery, Honorary Senior Lecturer in Orthopaedic Surgery, Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford Radcliffe Hospitals NHS Foundation Trust, Oxford, UK.

Managing chronic osteomyelitis can be challenging and attention to the osseous dead-space left following resection is an important part of successful treatment. We assess radiographic bone healing following implantation of a gentamicin-eluting synthetic bone graft substitute (gBGS) used at chronic osteomyelitis (cOM) resection. We also describe histological carrier changes from biopsies in nine cases at various time points. Read More

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http://dx.doi.org/10.7150/jbji.31592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470655PMC

Daptomycin versus Vancomycin as Post-Operative Empirical Antibiotic Treatment for Prosthetic Joint Infections: A Case-Control Study.

J Bone Jt Infect 2019 2;4(2):72-75. Epub 2019 Mar 2.

Infectious Diseases Department, Gustave Dron Hospital of Tourcoing, France.

To compare safety and efficacy of Vancomycin (Van) versus Daptomycin (Dap) as post-operative empirical antibiotic treatment (PEAT) in patients with periprosthetic joint infections (PJIs). Medical charts of patients treated empirically with Van or Dap in the post-operative period of total hip/knee prosthesis septic revision until the results of intra-operative culture were reviewed. Cefotaxime, cefepime or aztreonam were used in combination with Dap or Van. Read More

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http://dx.doi.org/10.7150/jbji.22118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470651PMC

Perioperative Contamination of Orthopaedic Polyethylene Implants, Targeting Devices and Arthroscopes. Experts' Decision Tree and Literature Review.

J Bone Jt Infect 2019 16;4(2):65-71. Epub 2019 Feb 16.

Orthopaedic Trauma Surgery Unit, Department of the Locomotor Apparatus, Lausanne. University Hospital, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.

Sterility errors during orthopaedic procedures can be stressful for the surgeon or scrub nurse and lead to devastating infectious complications and liability issues. This paper aims to review orthopaedic surgeon practices and propose possible attitudes to adopt. Out of 1023 questionnaires sent, 170 orthopaedic surgeons answered a Volunteer Feedback Template (multiple-choice test) by SurveyMonkey® (San Mateo, CA, USA) anonymously. Read More

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http://dx.doi.org/10.7150/jbji.30613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470652PMC
February 2019

Segmental Bone Loss of the Clavicle due to Fracture-Related Infection: A Multidisciplinary Challenge.

J Bone Jt Infect 2019 16;4(2):60-64. Epub 2019 Feb 16.

University Hospitals Leuven, Department of Trauma Surgery, B-3000 Leuven, Belgium.

As the surgical treatment of clavicular fractures is increasingly utilized in orthopedics, the number of related complications rises as well. We present a case of segmental bone loss of the clavicle due to fracture-related infection. Treatment was based on a multidisciplinary team approach, which was important for a successful outcome. Read More

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http://dx.doi.org/10.7150/jbji.32580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470653PMC
February 2019

Is Gram staining still useful in prosthetic joint infections?

J Bone Jt Infect 2019 29;4(2):56-59. Epub 2019 Jan 29.

Service of Infectious Diseases, Hospital Clínic, University of Barcelona, Barcelona, Spain.

: is an independent risk factor for DAIR failure in patients with a late acute prosthetic joint infection (PJI). Therefore, identifying the causative microorganism in an acute setting may help to decide if revision surgery should be chosen as a first surgical approach in patients with additional risk factors for DAIR failure. The aim of our study was to determine the sensitivity of Gram staining in late acute PJI. Read More

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http://dx.doi.org/10.7150/jbji.31312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470656PMC
January 2019

Acute ST-segment Elevation Myocardial Infarction as the First Manifestation of Essential Thrombocytosis.

Cureus 2019 Feb 7;11(2):e4032. Epub 2019 Feb 7.

Oncology, Florida Cancer Specialists, Atlantis, USA.

A 36-year-old female with no significant past medical history presented with sudden onset of crushing substernal chest pain. When the emergency medical services (EMS) arrived, she had a cardiac arrest requiring defibrillation two times in the field prior to arriving at the hospital. In the emergency department (ED), the electrocardiogram (ECG) was significant for ST-elevation that suggested acute anterolateral infarct. Read More

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http://dx.doi.org/10.7759/cureus.4032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456283PMC
February 2019

[Pycnodysostosis: about a case].

Pan Afr Med J 2018 8;31:93. Epub 2018 Oct 8.

Service de Pédiatrie, Hôpital Militaire d'Instructions Mohamed V, CHU Ibn Sina, Rabat, Maroc.

Pycnodysostosis is a very rare genetic disease of the bone characterized by osteocondensation associated with dysmorphic syndrome and growth retardation. This study aims to highlight the phenotypic abnormalities, the radiological signs, the therapeutic and evolutionary features of pycnodysostosis in a 11-year old child. The child was referred by his dentist for clinical evaluation. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.93.8388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462148PMC
October 2018

Pulmonary alveolar microlithiasis diagnosed with radiography, CT, and bone scintigraphy.

Radiol Case Rep 2019 Jun 10;14(6):775-777. Epub 2019 Apr 10.

Pulmonary and Critical Care, Marshall University, 1249 15th St, Huntington, WV 25701, USA.

Pulmonary alveolar microlithiasis is rare disease characterized by accumulation of calcium phosphate microlithis in the alveoli. The pathogenesis relates to mutation in the gene SLC34A2 (solute carrier family 34 member 2) located on chromosome 4p15.2, which produces a defective sodium-phosphate cotransporter in alveolar epithelial type-2 cells, making these cells unable to clear phosphorus released during recycling of surfactant [1]. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.03.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460250PMC

Primary Mucoepidermoid Carcinoma of the Thyroid: A Report of a Rare Case with Bone Metastasis and Review of the Literature.

Case Rep Oncol 2019 Jan-Apr;12(1):248-259. Epub 2019 Mar 19.

Department of Head and Neck Surgery, Vietnam National Cancer Hospital, Hanoi, Vietnam.

Mucoepidermoid carcinomas (MECs) are generally found in salivary gland, but they have also been mentioned in other organs such as the larynx, esophagus, breast. MECs are considered to be a low-grade carcinoma and their occurrence in the thyroid is extremely rare. We present a 54-year-old male patient admitted to our clinic, complaining about having back pains for approximately three months. Read More

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http://dx.doi.org/10.1159/000498917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465688PMC

Evaluation of unmet clinical needs in prophylaxis and treatment of venous thromboembolism in high-risk patient groups: cancer and critically ill.

Thromb J 2019 15;17. Epub 2019 Apr 15.

9Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Beijing, China.

Background: Clinical practice shows that venous thromboembolism (VTE) presents a substantial burden in medical patients, and awareness and advocacy for its primary and secondary prevention remains inadequate. Specific patient populations, such as those with cancer and the critically ill, show elevated risk for VTE, bleeding or both, and significant gaps in VTE prophylaxis and treatment exist in these groups.

Objective: To present novel insights and consolidated evidence collected from experts, clinical practice guidelines and original studies on the unmet needs in thromboprophylaxis, and on the treatment of VTE in two high-risk patient groups: patients with cancer and the critically ill. Read More

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http://dx.doi.org/10.1186/s12959-019-0196-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466798PMC

Production of Soluble Receptor Activator of Nuclear Factor Kappa-Β Ligand and Osteoprotegerin by Apical Periodontitis Cells in Culture and Their Modulation by Cytokines.

Mediators Inflamm 2019 18;2019:8325380. Epub 2019 Mar 18.

Medical Faculty of the Military Medical Academy, Belgrade, Serbia.

RANKL, a bone-destructive cytokine, and OPG, its osteoprotective counterpart, are expressed in periapical lesions (PLs), which represent hystopatological manifestations of apical periodontitis. However, their regulation in PLs has not been elucidated yet. Therefore, our aim was to study the production of RANKL and OPG and their modulation by pro- and anti-inflammatory cytokines in PL cell cultures. Read More

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http://dx.doi.org/10.1155/2019/8325380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442274PMC
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