1,228,662 results match your criteria Bone & Joint Journal[Journal]


Validation of a freehand technique for cortical bone trajectory screws in the lumbar spine.

J Neurosurg Spine 2019 Apr 19:1-8. Epub 2019 Apr 19.

1Division of Orthopaedic Surgery, University of Toronto, Toronto.

OBJECTIVEThe cortical bone trajectory (CBT) technique for pedicle screw placement has gained popularity among spinal surgeons. It has been shown biomechanically to provide better fixation and improved pullout strength compared to a traditional pedicle screw trajectory. The CBT technique also allows for a less invasive approach for fusion and may have lower incidence of adjacent-level disease. Read More

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http://dx.doi.org/10.3171/2019.1.SPINE181402DOI Listing

Bone and soft tissue changes associated with a removable partial denture. A novel method with a fusion of CBCT and optical 3D images.

Comput Biol Med 2019 Mar 28;108:78-84. Epub 2019 Mar 28.

Department of Endodontics and Operative Dentistry, Faculty of Medicine, University of Ljubljana, Slovenia; Department of Restorative Dentistry and Endodontics, University Medical Centre Ljubljana, Slovenia. Electronic address:

Background: The purpose of this study was to propose a novel method for 3D evaluation of bone and mucosal changes in removable partial denture (RPD) foundation area using a fusion of cone beam computed tomography (CBCT) and optical 3D images.

Method: Two CBCT scans and three impressions, taken at insertion and after ten months of wearing the RPD, were acquired from five patients. 3D models of bone and surface were created from CBCT images and gypsum casts, respectively, spatially aligned and saved in Standard Tessellation Language file format. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.024DOI Listing

Calcaneal tuberosity fractures through prior Schantz pin sites in patients with diabetic neuropathy.

Foot (Edinb) 2019 Mar 2;39:96-99. Epub 2019 Mar 2.

Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, United States.

Schantz pin placement in the calcaneal tuberosity is a common procedure known to be complicated by pin site infections and nerve injuries. Fractures through Schantz pin sites has been reported mostly in diaphyseal bone. This case series highlights three patients with type 2 diabetes mellitus and diabetic neuropathy who were fixed in an external fixator frame with a pin through the calcaneal tuberosity. Read More

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http://dx.doi.org/10.1016/j.foot.2019.02.011DOI Listing

Discoidin domain receptor 2: An emerging pharmacological drug target for prospective therapy against osteoarthritis.

Pharmacol Rep 2019 Jan 15;71(3):399-408. Epub 2019 Jan 15.

Department of Pharmaceutical Sciences, Drug Discovery Research Laboratorty, Assam University, Silchar, Assam, India. Electronic address:

Discoidin domain receptor2 (DDR2), a cell membrane tyrosine kinase on chondrocytes surface plays main role in cell-ECM interaction during the progressive degeneration of articular cartilage in osteoarthritis. The degraded component of ECM, type II collagen upon DDR2 binding provokes synthesis of matrix metalloproteinases (MMPs), responsible for severe destruction of joint tissues. DDR2 knockout has been investigated to decline the expression of MMP-1 and 13. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.007DOI Listing
January 2019
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Fourier transform infrared spectroscopy research on subchondral bone in osteoarthritis.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 11;218:243-247. Epub 2019 Apr 11.

Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China. Electronic address:

Osteoarthritis (OA) is not only related to the degradation of articular cartilage, but also possibly to the changes of subchondral bone. The purpose of this study was to assess whether specific differences could be resolved from bone composition, as also contributed to OA. These differences were assessed by using Fourier transform infrared spectroscopy (FTIRS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193039
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http://dx.doi.org/10.1016/j.saa.2019.04.020DOI Listing
April 2019
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Radiosynthesis and pre-clinical evaluation of [Ga] labeled antimicrobial peptide fragment GF-17 as a potential infection imaging PET radiotracer.

Appl Radiat Isot 2019 Apr 10;149:9-21. Epub 2019 Apr 10.

Department of Nuclear Medicine, Klinikum Rechts Der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.

The antimicrobial peptide fragment GF-17 was synthesized in-house and conjugated with DOTA and measured molecular mass of DOTA-GF-17 conjugate was 2489 Da. The peptide conjugate was purified and labeled with [Ga]. The best radiolabeling efficiency (95. Read More

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http://dx.doi.org/10.1016/j.apradiso.2019.04.008DOI Listing

3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages.

Acta Biomater 2019 Apr 16. Epub 2019 Apr 16.

i3S - Instituto de Inovação e Investigação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

Chitosan (Ch) is used in different biomedical applications to promote tissue repair. However, tissue injury caused by biomaterial implantation lead to the release of danger signals that engage different inflammatory pathways on the host. Different implanted materials activate the inflammasome leading to the modulation of the immune response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193027
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http://dx.doi.org/10.1016/j.actbio.2019.04.035DOI Listing
April 2019
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Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8 T cells.

Acta Biomater 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands. Electronic address:

Outer membrane vesicles (OMVs) are vesicular nano-particles produced by Gram-negative bacteria that are recently being explored as vaccine vector. The fact that OMVs can be efficiently produced by a hypervesiculating Salmonella typhimurium strain, are packed with naturally-occurring adjuvants like lipopolysaccharides (LPS), and can be engineered to express any antigen of choice, makes them ideal candidates for vaccinology. However, it is unclear whether OMVs induce dendritic cell (DC)-mediated antigen-specific T cell responses and how immune activation is coordinated. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.033DOI Listing

Spontaneous bone regeneration following a large craniectomy in a pediatric patient: a case report.

World Neurosurg 2019 Apr 16. Epub 2019 Apr 16.

Institute of Neurology and Neurosurgery, Hospital Zambrano Hellion, Tecnologico de Monterrey, San Pedro Garza Garcia, Nuevo Leon, Mexico.

Background: In children, decompressive craniectomy is commonly performed in cases of increased intracranial pressure that is not medically managed. Currently, it is standard practice to perform cranioplasty after decompressive craniectomy, although optimal timing for the procedure remains controversial. To date, few studies have reported spontaneous cranial bone regeneration in children without intervention. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.085DOI Listing

Effect of selective serotonin reuptake inhibitors on markers of bone loss.

Psychiatry Res 2019 Apr 3;276:39-44. Epub 2019 Apr 3.

Pharmaceutical Medicine, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

Several preclinical and clinical studies show that selective serotonin reuptake inhibitors (SSRI's) are associated with bone loss and an increase in fracture risk, not many reports on their effect on bone turnover markers. This cross-sectional study evaluated the effect of SSRIs treatment on bone turnover markers in Indian population for the first time. Inclusion criteria were subjects of either sex and age 18-45 years undergoing treatment with an SSRI for at least 3 months, regardless of the indication. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.04.006DOI Listing

The skeletal renin-angiotensin system: A potential therapeutic target for the treatment of osteoarticular diseases.

Int Immunopharmacol 2019 Apr 16;72:258-263. Epub 2019 Apr 16.

Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.

The classical renin-angiotensin system (RAS) is known to be a key regulator of blood pressure as well as fluid and electrolyte homeostasis. Additionally, it is now evident that components of the RAS are produced and act locally in many tissues, including liver, kidney, heart, lung, eye, bone, reproductive organ, adipose, and adrenal tissue, and these components are collectively known as tissue RAS. Recently, several studies have shown that local bone RAS is directly involved in bone metabolism, and activation of skeletal RAS plays an important role in bone diseases, such as osteoporosis, arthritis, and deterioration as well as in fracture healing. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.023DOI Listing
April 2019
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Population Pharmacokinetics of Clofarabine as Part of Pre-Transplant Conditioning in Pediatric Subjects Prior to Hematopoietic Cell Transplantation (HCT).

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatrics, Division of Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, CA; Department of Clinical Pharmacy, University of California San Francisco, San Francisco, CA.

The primary objective of this work was to characterize the pharmacokinetics (PK) of systemic clofarabine (clo-fara) in pediatric allogeneic hematopoietic cell transplantation (HCT) recipients receiving either nucleoside monotherapy or a dual nucleoside analogue preparative regimen. Fifty-one children (median age 4.9 years, range 0. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.017DOI Listing

Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic stem cell transplantation program in countries with limited resources (Part II): clinical, technical and socio-economic considerations.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Center for Hematopoietic Stem Cell Transplantation, Aichi Medical University Hospital, Nagakute; Department of Hematology and Medical Oncology, University Hospital, Leipzig, Germany.

The development of hematopoietic stem cell transplantation (HSCT) programs can face significant challenges in most developing countries because such endeavors must compete with other government health care priorities, including the delivery of basic services. While this is may be a limiting factor, these countries should prioritize development of the needed expertise to offer state of the art treatments including transplantation, by providing financial, technological, legal, ethical and other needed support. This would prove beneficial in providing successful programs customized to the needs of their population, and potentially provide long-term cost-savings by circumventing the need for their citizens to seek care abroad. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.012DOI Listing

[18F]fludeoxyglucose PET/CT in small-cell lung cancer: Analysis of the CONVERT randomized controlled trial.

J Thorac Oncol 2019 Apr 16. Epub 2019 Apr 16.

Division of Cancer Sciences, University of Manchester, Manchester, UK; Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK.

Introduction: We used phase-3 CONVERT trial data to investigate the impact of fludeoxyglucose (F-FDG) PET/CT in small-cell lung cancer (SCLC).

Methods: CONVERT randomized limited-stage SCLC patients to twice-daily (45Gy in 30-fractions) or once-daily (66Gy in 33-fractions) chemoradiotherapy. Patients were divided into 2 groups in this unplanned analysis: those staged with conventional imaging (contrast-enhanced thorax and abdomen CT and brain imaging with/without bone scintigraphy) and those staged with F-FDG PET/CT in addition. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.03.023DOI Listing

A machine learning approach to knee osteoarthritis phenotyping: Data from the FNIH Biomarkers Consortium.

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Objective: Knee osteoarthritis (KOA) is a heterogeneous condition representing a variety of potentially distinct phenotypes. The purpose of this study was to apply innovative machine learning approaches to KOA phenotyping in order to define progression phenotypes that are potentially more responsive to interventions.

Design: We used publicly available data from the FNIH OA Biomarkers Consortium, where radiographic (medial joint space narrowing of ≥0. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.027DOI Listing

Multilayer nanoscale functionalisation to treat disorders and enhance regeneration of bone tissue.

Nanomedicine 2019 Apr 16. Epub 2019 Apr 16.

School of Engineering, Newcastle University, Claremont Road, Newcastle upon Tyne NE1 7RU, United Kingdom. Electronic address:

The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.009DOI Listing

The maintenance of an oral epithelial barrier.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu, Sichuan 610041, China. Electronic address:

Oral epithelial barrier consists of closely controlled structure of the stratified squamous epithelium, which is the gateway to human bodies and encounters a huge burden of microbial, airborne and dietary antigens, as well as masticatory damage. Once this barrier is destroyed, it will trigger bone loss, tissue damage and microbial dysbiosis and lead to diseases, such as periodontitis, oral mucosal diseases and oral cancer. Recently, increasing evidences showed that different factors including microorganism, saliva, proteins and immune components have been considered to play a critical role in the disruption of oral epithelial barrier. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193028
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http://dx.doi.org/10.1016/j.lfs.2019.04.029DOI Listing
April 2019
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XPro1595 ameliorates bone cancer pain in rats via inhibiting p38-mediated glial cell activation and neuroinflammation in the spinal dorsal horn.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Human Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, Preclinical School of Medicine, The Fourth Military Medical University, Xi'an 710032, PR China. Electronic address:

Bone cancer pain (BCP) profoundly compromises the life quality of patients with bone metastases. Severe side effects of the drugs which were widely used and effective in the various stages of this condition results in a huge challenge for BCP treatment. Here, we investigated the antinociceptive effects of XPro1595, a soluble tumor necrosis factor (solTNF) inhibitor with considerable immunoregulatory efficacy, on BCP, as well as the underlying mechanisms within the spinal dorsal horn (SDH). Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.009DOI Listing

Protective Effects of Mesenchymal Stem Cells Overexpressing Extracellular Regulating Kinase 1/2 Against Stroke in Rats.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Shanghai Tongji hospital, Tongji University School of Medicine, Shanghai, 200065, China. Electronic address:

Objective: Although transplantation of bone marrow-derived mesenchymal stem cells (MSCs) has shown beneficial effects on stroke, lower survival of MSCs limits effects. Extracellular regulating kinase 1/2 signaling (ERK1/2) is crucial for cell survival, differentiation, and proliferation. This study was designed to explore whether MSCs modified by over-expressing ERK1/2 may reinforce beneficial effects on stroke in rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.006DOI Listing

Design and evaluation of chitosan/chondroitin sulfate/nano-bioglass based composite scaffold for bone tissue engineering.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

School of Biochemical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, India. Electronic address:

Chitosan, a natural biopolymer with osteoconductive properties is widely investigated to generate scaffolds for bone tissue engineering applications. However, chitosan based scaffolds lacks in mechanical strength and structural stability in hydrated condition and thereby limits its application for bone tissue regeneration. Thus in the present study, to overcome the limitations associated with chitosan based scaffolds, we fabricated polyelectrolyte complexation mediated composite scaffold of chitosan and chondroitin sulfate incorporated with nano-sized bioglass. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183730
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.107DOI Listing
April 2019
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Chitosan and gelatin-based electrospun fibers for bone tissue engineering.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, India. Electronic address:

Fractures and injuries pertaining to bone tissue usually take prolonged periods for its natural healing. To overcome this problem, the field of bone tissue engineering (BTE) has acquired an efficient designing mechanism that incorporates cells, biomaterials and the corresponding growth factors to promote both osteogenesis as well as mineralization of the bone. Amidst the various techniques available for scaffold creation, electrospinning is considered superior as it paves the way for the creation of nanostructured scaffolds using biopolymers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193161
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.115DOI Listing
April 2019
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Antibacterial free-standing polysaccharide composite films inspired by the sea.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's PT Associate Laboratory, Guimarães, Portugal. Electronic address:

The adhesive capabilities of marine mussel proteins are well-known, exhibiting the ability to stick to different underwater substrates, either inorganic or organic. These unique adhesive properties are due to the high levels of amino acid, 3,4-dihydroxyphenyl-l-alanine (DOPA), which presents the reactive catechol group. Herein, novel antibacterial free-standing (FS) films were developed with natural polymers, namely chitosan (CHT) and hyaluronic acid (HA), being the catechol-functionalized hyaluronic acid (HA-DN) also included to provide wet adhesive properties. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.102DOI Listing

Infrared spectroscopic study of the coil-helix transition of highly concentrated gelatin formulations.

Eur J Pharm Biopharm 2019 Apr 16. Epub 2019 Apr 16.

University of Heidelberg, IPMB, Department of Pharmaceutical Technology and Biopharmaceutics, Im Neuenheimer Feld 329, 69120 Heidelberg, Germany. Electronic address:

The aim of this study was to investigate the applicability of ATR-FTIR spectroscopy as an analytical tool to monitor the gel formation of highly concentrated gelatin formulations. Spectral changes induced by the coil-helix transition have been studied and related to the elasticity parameter G' obtained by oscillatory rheology in simultaneous measurements. A principal component analysis of the amide I band allowed the evaluation of triple helix formation kinetics. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.04.010DOI Listing

Molecular impacts of photobiomodulation on bone regeneration: A systematic review.

Prog Biophys Mol Biol 2019 Apr 16. Epub 2019 Apr 16.

School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia. Electronic address:

Photobiomodulation (PBM) encompasses a light application aimed to increase healing process, tissue regeneration, and reducing inflammation and pain. PBM is specifically aimed to modify the expression of cellular molecules; however, PBM impacts on cellular and molecular pathways especially in bone regenerative medicine have been investigated in scattered different studies. The purpose of the current study is to systematically review evidence on molecular impact of PBM on bone regeneration. Read More

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http://dx.doi.org/10.1016/j.pbiomolbio.2019.04.005DOI Listing

Tissue engineered models of healthy and malignant human bone marrow.

Adv Drug Deliv Rev 2019 Apr 16. Epub 2019 Apr 16.

Columbia University, New York, USA. Electronic address:

Tissue engineering is becoming increasingly successful in providing in vitro models of human tissues that can be used for ex vivo recapitulation of functional tissues as well as predictive testing of drug efficacy and safety. From simple tissue models to microphysiological platforms comprising multiple tissue types connected by vascular perfusion, these "tissues on a chip" are emerging as a fast track application for tissue engineering, with great potential for modeling diseases and supporting the development of new drugs and therapeutic targets. We focus here on tissue engineering of the hematopoietic stem and progenitor cell compartment and the malignancies that develop in the human bone and bone marrow. Read More

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http://dx.doi.org/10.1016/j.addr.2019.04.003DOI Listing

Maintenance of Segmental Maxillary Expansion: The Use of Custom, Virtually Designed, and Manufactured Palatal Appliances Without the Use of an Occlusal Splint.

J Oral Maxillofac Surg 2019 Mar 26. Epub 2019 Mar 26.

Private Practitioner, Carolinas Center for Oral and Facial Surgery, Charlotte, NC; Clinical Assistant Professor, Department of Oral and Maxillofacial Surgery, Louisiana State University School of Dentistry, New Orleans, LA.

Expansion of the maxilla using a segmental Le Fort I osteotomy is a routine and commonly used procedure in the treatment of dentofacial deformities. Although orthognathic surgery has seen tremendous advancement in technology, including virtual surgical planning and customized hardware, some room for advancement exists in the maintenance of surgical maxillary expansion. Traditionally, this has been accomplished with retention of a maxillary occlusal splint 4 to 8 weeks postoperatively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391193033
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http://dx.doi.org/10.1016/j.joms.2019.03.013DOI Listing
March 2019
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Computational Modeling of Bone Cells and Their Biomechanical Behaviors in Responses to Mechanical Stimuli.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):51-67

Department of Hand surgery, Department of Plastic Reconstructive Surgery, Ningbo No. 6 Hospital, Ningbo, 315040, China; School of Pharmacy and Medical Sciences, and UniSA Cancer Research Institute, University of South Australia, Adelaide, SA 5001, Australia.

Bone cells, including osteoblasts, osteoclasts, and osteocytes, have the ability to develop and maintain bone architecture. Although improved experimental testing approaches are increasing our understanding of the complex structures and functions of bone cells and bone, computational models, particularly finite element analyses, are being used to extend this knowledge and to develop a more theoretical understanding of bone cell behaviors. There are many challenges to developing an accurate and validated computational model due to the complex structure and biomechanical behaviors of the bone cells and bone tissue. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2019025150DOI Listing
January 2019

Simulating Time-Dependent Patterns of Nonadherence by Patients With Breast Cancer to Adjuvant Oral Endocrine Therapy.

JCO Clin Cancer Inform 2019 Apr(3):1-9

1 University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: Nearly 40% of patients with breast cancer discontinue their adjuvant oral endocrine treatment (ET). We measured discontinuation rates of ET at a comprehensive cancer center. We then used an iterative approach to model patterns of determinants associated with discontinuation of ET. Read More

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https://ascopubs.org/doi/10.1200/CCI.18.00091
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http://dx.doi.org/10.1200/CCI.18.00091DOI Listing
April 2019
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GdX/UBL4A-knockout mice resist collagen-induced arthritis by balancing the population of T1/T17 and regulatory T cells.

FASEB J 2019 Apr 19:fj201802217RR. Epub 2019 Apr 19.

State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.

Rheumatoid arthritis (RA) is an autoimmune disease associated with synovial hyperplasia and bone and cartilage destruction. T cells, notably T helper (T)-1 and T17 cells, play a critical role in the pathologic process of RA. However, it remains unclear how T1 and T17 cells are regulated during RA. Read More

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http://dx.doi.org/10.1096/fj.201802217RRDOI Listing

Tao negatively regulates BMP signaling during neuromuscular junction development in Drosophila.

Dev Neurobiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Biology, John Carroll University, University Heights, OH, 44118, USA.

The coordinated growth and development of synapses is critical for all aspects of neural circuit function and mutations that disrupt these processes can result in various neurological defects. Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway, regulate synaptic development in vertebrates and invertebrates. At the Drosophila larval neuromuscular junction (NMJ), the retrograde BMP pathway is part of the machinery that controls NMJ expansion concurrent with larval growth. Read More

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http://dx.doi.org/10.1002/dneu.22681DOI Listing

Methylation of the promoter region of the MTRR gene in childhood acute lymphoblastic leukemia.

Oncol Rep 2019 Apr 12. Epub 2019 Apr 12.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu 730030, P.R. China.

Epigenetic analysis of the association between the methylation status of the promoter region of the MTRR (5‑methyltetrahydrofolate‑homocysteine methyltransferase reductase) gene and the risk of acute lymphoblastic leukemia (ALL) in children plays an important role in the early diagnosis, assessment of the malignant degree, treatment and evaluation of the risk of relapse and prognosis of the disease. In the present study, RT‑qPCR was used to detect the mRNA levels of the MTRR and MTHFR (methylenetetrahydrofolate reductase) genes in the bone marrow of 20 ALL patients and 20 age‑ and sex‑matched controls with normal bone marrow. The methylation pattern of the MTRR promoter region in eligible DNA samples was quantitatively analyzed using MALDI‑TOF MS. Read More

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http://www.spandidos-publications.com/10.3892/or.2019.7114
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http://dx.doi.org/10.3892/or.2019.7114DOI Listing
April 2019
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Comparison of Risk of Osteoporotic Fracture in Denosumab vs Alendronate Treatment Within 3 Years of Initiation.

JAMA Netw Open 2019 Apr 5;2(4):e192416. Epub 2019 Apr 5.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Importance: Head-to-head randomized clinical trials showed greater efficacy of denosumab vs alendronate in improving bone mineral density. Although there is an association of changes in bone mineral density with reductions in fracture risk, the magnitude of the association is not well established.

Objective: To compare the risk of hip and any fracture in patients treated with denosumab and alendronate in routine practice settings. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2416DOI Listing
April 2019
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Influences of hucMSC-exosomes on VEGF and BMP-2 expression in SNFH rats.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2935-2943

Department of Orthopaedics, The General Hospital of Jinan Military, Jinan, China.

Objective: To investigate the influences of human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-exosome) on steroid-induced necrosis of the femoral head (SNFH) and the expressions of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) in rats.

Patients And Methods: A total of 20 male Sprague-Dawley rats were randomly divided into SNFH group and SNFH + hucMSC-exosome group using a random number table. Prednisolone acetate (24. Read More

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http://www.europeanreview.org/article/17573
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http://dx.doi.org/10.26355/eurrev_201904_17573DOI Listing
April 2019
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A pilot study of human mesenchymal stem cells from visceral and sub-cutaneous fat tissue and their differentiation to osteogenic phenotype.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2924-2934

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Objective: To evaluate the different behavior of two different human adult adipocytes derived stem cells (hASCs) during proliferation and osteogenic differentiation.

Patients And Methods: Human adult adipocytes stem cells (hAT-SCs) from visceral (hAV-SCs) and subcutaneous (hAS-SCs) sites were obtained after surgery procedures of seven patients. All samples were fully investigated and the different proliferation rates were evaluated. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17572DOI Listing

MiR-21 promotes fracture healing by activating the PI3K/Akt signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2727-2733

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: This study aims to elucidate the potential mechanism of micro ribonucleic acid (miR)-21 in promoting fracture healing.

Materials And Methods: 30 male Sprague-Dawley rats were randomly divided into group A (phosphate-buffered saline, PBS, n=10), group B (AntagomiR-21, n=10) and group C (AntagomiR-NC, n=10) according to the different treatments. The femoral fracture operation was performed in every rat, which was pathologically diagnosed via X-ray. Read More

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http://www.europeanreview.org/article/17544
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http://dx.doi.org/10.26355/eurrev_201904_17544DOI Listing
April 2019
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Correlation between miR-1207-5p expression with steroid-induced necrosis of femoral head and VEGF expression.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2710-2718

Department of Orthopedic, Daqing Oilfield General Hospital, Daqing, China.

Objective: The aim of this study was to investigate the expression level of micro-ribonucleic acid-1207-5p (miR-1207-5p) in steroid-induced necrosis of femoral head (SNFH) and its correlation with SNFH. Meanwhile, we also aimed to analyze the relationship between miR-1207-5p expression and vascular endothelial growth factor (VEGF) in the femoral head.

Patients And Methods: From May 2016 to December 2017, 60 patients aged (55. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17541DOI Listing

[Intracardiac and Pulmonary Cement Embolism after Percutaneous Vertebroplasty].

Kardiologiia 2019 Apr 18;59(4):92-96. Epub 2019 Apr 18.

Central Clinical Hospital of the Management Affair of President RF, Moscow.

The article presents a clinical case of embolism with bone cement of the right ventricle of the heart and pulmonary artery after percutaneous vertebroplasty in a patient aged 63 years. According to the results of a comprehensive examination using ultrasound and x-ray methods, three foreign bodies were found: in the right ventricle cavity, in the trunk of the pulmonary artery, in the branches of the left pulmonary artery. Considering the stable condition, normal blood oxygen saturation, the lack of influence of formations on intracardiac hemodynamics, it was decided to refrain from surgery, since the risk of intervention exceeded the possible benefit. Read More

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http://dx.doi.org/10.18087/cardio.2019.4.10255DOI Listing

[Dynamics of Coronary Calcification and Its Association with the Clinical Course of Ischemic Heart Disease and Osteopenic Syndrome].

Kardiologiia 2019 Apr 16;59(4):12-20. Epub 2019 Apr 16.

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo Kemerovo State Medical University.

Purpose: to study the relationship between degree of calcification of coronary arteries, osteopenic syndrome, and clinical course of ischemic heart disease (IHD) during 3-5 years of follow-up in men after coronary artery bypass grafting (CABG). Materials and methods. We included in this prospective study 111 men admitted for CABG under cardiopulmonary bypass. Read More

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http://dx.doi.org/10.18087/cardio.2019.4.10247DOI Listing

Photobiomodulation increases intrusion tooth movement and modulates IL-6, IL-8 and IL-1β expression during orthodontically bone remodeling.

J Biophotonics 2019 Apr 19:e201800311. Epub 2019 Apr 19.

R. Dr. José Rocha Junqueira, 13 - Pte. Preta, Campinas, SP, Brazil.

This study investigated the effects of photobiomodulation (PBM) on upper molar intrusion movement, regarding acceleration of orthodontic movement and its molecular effects. The sample consisted of 30 patients with indication of tooth intrusion for oral rehabilitation. Teeth were divided into three different groups: G1 (n=10) pre-molars without force or laser application (control); G2 (n=10) upper molar intrusion; and G3 (n=10) upper molar intrusion and PBM. Read More

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http://dx.doi.org/10.1002/jbio.201800311DOI Listing

Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity.

Microbiologyopen 2019 Apr 18:e00810. Epub 2019 Apr 18.

Department of endocrinology and metabolism, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

The complex relationship between intestinal microbiota and host is a novel field in recent years. A large number of studies are being conducted on the relationship between intestinal microbiota and bone metabolism. Bone metabolism consisted of bone absorption and formation exists in the whole process of human growth and development. Read More

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http://dx.doi.org/10.1002/mbo3.810DOI Listing

Nimotuzuma restrains proliferation and induces apoptosis in human osteosarcoma cells by regulation of EGFR/PI3K/AKT signal pathway.

J Cell Physiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Osteosarcoma (OS) is a conversant malignant bone tumor, commonly occurs in children and adolescents. Nimotuzuma is an epidermal growth factor receptor (EGRF) monoclonal antibody agent, which has been exploited in varied solid tumors. Nevertheless, the functions of Nimotuzuma in OS remain blurry. Read More

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http://dx.doi.org/10.1002/jcp.28693DOI Listing

Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice.

Purinergic Signal 2019 Apr 18. Epub 2019 Apr 18.

School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, 2522, Australia.

Graft-versus-host disease (GVHD) is a life-threatening consequence of allogeneic haematopoietic stem cell transplantation, a curative therapy for haematological malignancies. The ATP-gated P2X7 receptor channel is implicated in the development of GVHD. P2X7 activity on human leukocytes can be influenced by gain-of-function (GOF) and loss-of-function (LOF) single nucleotide polymorphisms (SNPs) in the P2RX7 gene. Read More

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http://dx.doi.org/10.1007/s11302-019-09651-8DOI Listing

Tissue composition and allometric growth of carcass of lambs Santa Inês and crossbreed with breed Dorper.

Trop Anim Health Prod 2019 Apr 18. Epub 2019 Apr 18.

Institute of Veterinary Medicine, Post-Graduate Program in Animal Science, Federal University of Pará, Castanhal, Pará, 68746-360, Brazil.

This study aimed to assess the tissue composition and allometric growth of carcasses of Santa Inês and crossbred Dorper x Santa Inês lambs confined for different periods at three body weight classes. Sixty-four lambs from Santa Inês (SI) and crossbred Dorper x Santa Inês (DSI) were slaughtered. The carcasses were refrigerated at 4 °C for 24 h, and half of the right side carcass was divided into five primary cuts, which were then dissected into bone, muscle, and fat. Read More

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http://dx.doi.org/10.1007/s11250-019-01886-2DOI Listing

Bone marrow pericyte dysfunction in individuals with type 2 diabetes.

Diabetologia 2019 Apr 17. Epub 2019 Apr 17.

Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Level 7, Upper Maudlin Street, Bristol, BS2 8HW, UK.

Aims/hypothesis: Previous studies have shown that diabetes mellitus destabilises the integrity of the microvasculature in different organs by damaging the interaction between pericytes and endothelial cells. In bone marrow, pericytes exert trophic functions on endothelial cells and haematopoietic cells through paracrine mechanisms. However, whether bone marrow pericytes are a target of diabetes-induced damage remains unknown. Read More

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http://dx.doi.org/10.1007/s00125-019-4865-6DOI Listing

Corrigendum: Viscoelastic and Functional Properties of Cod-Bone Gelatin in the Presence of Xylitol and Stevioside.

Front Chem 2019 2;7:120. Epub 2019 Apr 2.

College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China.

[This corrects the article DOI: 10.3389/fchem.2018. Read More

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http://dx.doi.org/10.3389/fchem.2019.00120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456742PMC

Fracture Healing Monitoring by Impact Tests: Single Case Study of a Fractured Tibia With External Fixator.

IEEE J Transl Eng Health Med 2019 15;7:2100206. Epub 2019 Mar 15.

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e ChirurgiaUniversità di Pisa56122PisaItaly.

The correct evaluation of the healing process is important to define proper times of fixator dynamization and removal, avoiding refractures. Unfortunately, a quantitative healing assessment is not yet available in clinical practice. The aim of the paper is to prove the feasibility of the mechanical vibration method to assess bone healing in fractures treated with external fixation, in conditions. Read More

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https://ieeexplore.ieee.org/document/8667865/
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http://dx.doi.org/10.1109/JTEHM.2019.2901455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467180PMC
March 2019
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Orthopedic Manifestations of Bruck Syndrome: A Case Series with Intermediate to Long-term Follow-Up.

Case Rep Orthop 2019 13;2019:8014038. Epub 2019 Mar 13.

Department of Orthopedic Surgery, Alfred I. duPont Hospital for Children, Wilmington, DE, USA.

The aim of this study was to evaluate the association of contractures, fractures, and deformities in four patients with Bruck syndrome treated in our facility. Data were collected from medical records, radiographs, dual-energy X-ray absorptiometry (DEXA) scans, genetic tests, and gait analysis. All had contractures at birth and genotypic findings including mutations in PLOD2 or FPKB10. Read More

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http://dx.doi.org/10.1155/2019/8014038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436336PMC

Low-Grade Chondrosarcoma of the Proximal Phalanx: A Rare Presentation.

Case Rep Orthop 2019 14;2019:6402979. Epub 2019 Mar 14.

St. John Macomb-Oakland Hospital, Madison Heights Campus, 27351 Dequindre Rd, Madison Heights, MI 48071, USA.

Case: Chondrosarcomas are the second most common primary malignant sarcoma of the bone, though it is overall a rare tumor. Our case presents a 36-year-old Caucasian male who complained of an enlarging mass at his third finger MCP joint. After assessing the full clinical scenario, it was determined that wide excision with ray resection would provide the best result for this patient. Read More

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http://dx.doi.org/10.1155/2019/6402979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437730PMC

A 40-Year-Old Male Presenting with Hereditary Multiple Exostosis: Management and Considerations.

Case Rep Orthop 2019 13;2019:4793043. Epub 2019 Mar 13.

Lake Erie College of Osteopathic Medicine, D.O., M.S.B.S, 5515 Peach Street, Erie, PA 16509, USA.

Hereditary multiple exostosis is a rare condition in which numerous benign osteochondromas form throughout the body, typically in areas of high bone turnover such as the metaphyseal plates of long bones. While many of these lesions remain clinically asymptomatic, other growth locations can lead to excruciating pain, limit a joint's range of motion, and compromise neurovascular structures. These patients undergo multiple surgeries throughout their lifetime in order to remove symptomatic osteochondromas. Read More

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https://www.hindawi.com/journals/crior/2019/4793043/
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http://dx.doi.org/10.1155/2019/4793043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436337PMC
March 2019
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Orthodontic treatment of patient with maxillofacial fibrous dysplasia: A case report.

J Clin Exp Dent 2019 Mar 1;11(3):e296-e302. Epub 2019 Mar 1.

College of Dental Medicine, Medical University of South Carolina, Charleston SC, USA.

Fibrous dysplasia is a benign skeletal disorder in which the normal bone and marrow are replaced by fibrous tissue and haphazardly distributed woven bone. The aim of this case report is to discuss the orthodontic treatment of a 13-year-old patient with fibrous dysplasia in the left maxilla. The patient had rotated maxillary second premolars, moderate crowding in both maxillary and mandibular arches with low maxillary frenal attachment. Read More

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http://dx.doi.org/10.4317/jced.55584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461730PMC
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