7,523 results match your criteria Bone[Journal]


Osteocytes reflect a pro-inflammatory state following spinal cord injury in a rodent model.

Bone 2018 Dec 11. Epub 2018 Dec 11.

Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, TX, United States of America.

Profound bone loss occurs following spinal cord injury (SCI) resulting in a high incidence of fractures. While likely caused in part by loss of weight-bearing, there is greater bone loss following SCI when compared to that observed in other disuse animal models. Patients with SCI have a protracted inflammatory response, with elevated circulating levels of pro-inflammatory markers. Read More

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December 2018

Potential role of senescence in radiation-induced damage of the aged skeleton.

Bone 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine, Mayo Clinic School of Medicine, Mayo Clinic, Rochester, MN, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address:

Human aging-related changes are exacerbated in cases of disease and cancer, and conversely aging is a catalyst for the occurrence of disease and multimorbidity. For example, old age is the most significant risk factor for cancer and among people who suffer from cancer, >60% are above the age of 65. Oxidative stress and DNA damage, leading to genomic instability and telomere dysfunction, are prevalent in aging and radiation-induced damage and are major cellular events that lead to senescence. Read More

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December 2018

Sclerosing bone dysplasias with hallmarks of dysosteosclerosis in four patients carrying mutations in SLC29A3 and TCIRG1.

Bone 2018 Dec 8. Epub 2018 Dec 8.

Institut für Medizinische Genetik und Humangenetik, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

The osteopetroses and related sclerosing bone dysplasias can have a broad range of manifestations. Especially in the milder forms, sandwich vertebrae are an easily recognizable and reliable radiological hallmark. We report on four patients from three families presenting with sandwich vertebrae and platyspondyly. Read More

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December 2018
1 Read

Mid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults: The Healthy Ageing Initiative.

Bone 2018 Dec 8. Epub 2018 Dec 8.

Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.

Background: Lower skeletal muscle density, indicating greater infiltration of adipose tissue into muscles, is associated with higher fracture risk in older adults. We aimed to determine whether mid-calf muscle density is associated with falls risk and bone health in community-dwelling older adults.

Methods: 2214 community-dwelling men and women who participated in the Healthy Ageing Initiative (Sweden) study at age 70 were included in this analysis. Read More

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December 2018
2 Reads

Spatially matching morphometric assessment of cartilage and subchondral bone in osteoarthritic human knee joint with micro-computed tomography.

Bone 2018 Dec 7. Epub 2018 Dec 7.

SCANCO Medical AG, Brüttisellen, Switzerland; Department of Research and Development, Schulthess Klinik, Zürich, Switzerland. Electronic address:

Objective: The objective of this study was to develop a reproducible and semi-automatic method based on micro computed tomography (microCT) to analyze cartilage and bone morphology of human osteoarthritic knee joints in spatially matching regions of interest.

Materials And Methods: Tibial plateaus from randomly selected patients with advanced osteoarthritis (OA) who underwent total knee arthroplasty surgery were microCT scanned once fresh and once after staining with Hexabrix. The articular surface was determined manually in the first scan. Read More

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December 2018
1 Read

Deletion of OPN in BSP knockout mice does not correct bone hypomineralization but results in high bone turnover.

Bone 2018 Dec 4. Epub 2018 Dec 4.

Inserm U1059-Sainbiose, Université de Lyon, F 42270 Saint Priest en Jarez, France. Electronic address:

The two SIBLING (Small Integrin Binding Ligand N-linked Glycoproteins), bone sialoprotein (BSP) and osteopontin (OPN) are expressed in osteoblasts and osteoclasts. In mature BSP knockout (KO, ) mice, both bone formation and resorption as well as mineralization are impaired. OPN mice display impaired resorption, and OPN is described as an inhibitor of mineralization. Read More

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December 2018

Expression of concern.

Authors:

Bone 2018 Dec 5. Epub 2018 Dec 5.

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December 2018

miRNA-seq analysis of human vertebrae provides insight into the mechanism underlying GIOP.

Bone 2018 Nov 29;120:371-386. Epub 2018 Nov 29.

Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. Electronic address:

High-throughput sequencing (HTS) was recently applied to detect microRNA (miRNA) regulation in age-related osteoporosis. However, miRNA regulation has not been reported in glucocorticoid-induced osteoporosis (GIOP) patients and the mechanism of GIOP remains elusive. To comprehensively analyze the role of miRNA regulation in GIOP based on human vertebrae and to explore the molecular mechanism, a high-throughput sequencing strategy was employed to identify miRNAs involved in GIOP. Read More

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November 2018
1 Read

Microscopic markers of an infradian biorhythm in human juvenile ribs.

Bone 2018 Nov 29. Epub 2018 Nov 29.

Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury CT2 7NR, England, United Kingdom.

Recent studies have indicated that there may be an infradian systemic biorhythm that coordinates aspects of human hard tissue growth and influences adult body size. Here we investigate if evidence of this biorhythm retained in human teeth as the periodicity of Retzius lines (RP) corresponds with the microstructural growth of a non-weight bearing bone, the rib, in a sample of 50 human juvenile skeletons. Using static histomorphometric methods, the RP of one permanent tooth from each skeleton was calculated and combined with measures of bone remodeling in a rib from the same individual. Read More

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November 2018
1 Read

A new noninvasive mechanical bending test accurately predicts ulna bending strength in cadaveric human arms.

Bone 2018 Nov 26;120:336-346. Epub 2018 Nov 26.

Department of Biological Sciences, Ohio University, Athens, OH 45701, United States of America; Ohio Musculoskeletal and Neurological Institute, Ohio University, Athens, OH 45701, United States of America. Electronic address:

Background: High error rates in the prediction of fragility fractures by bone mineral density have motivated searches for better clinical indicators of bone strength, and the high incidence of non-hip, non-spine fractures has raised interest in cortical bone. The aim of this study was to assess the accuracy of Cortical Bone Mechanics Technology™. CBMT is a new non-invasive 3-point bending technique for measuring the mechanical properties of cortical bone in the ulnas of living humans. Read More

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November 2018

Alterations of the gut microbiome and plasma proteome in Chinese patients with adolescent idiopathic scoliosis.

Bone 2018 Nov 24;120:364-370. Epub 2018 Nov 24.

Department of Rehabilitation, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Department of Rehabilitation, Xinhua Hospital (Chongming Branch), Shanghai Jiao Tong University School of Medicine, Shanghai 202150, China. Electronic address:

The etiology of adolescent idiopathic scoliosis (AIS), the most common rotational deformity of the spine, is still unclear. Emerging evidence suggests that gut microbiota dysbiosis influences musculoskeletal diseases such as arthritis and osteoporosis. However, the alterations of the fecal microbiome in AIS remain unknown. Read More

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November 2018
2 Reads

Bone Marrow Adiposity- Special Edition.

Bone 2019 Jan;118

Tufts University School of Medicine, Maine Medical Center Research Institute Scarborough, Maine USA. Electronic address:

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January 2019
2 Reads

SHP2 regulates intramembranous ossification by modifying the TGFβ and BMP2 signaling pathway.

Bone 2018 Nov 22;120:327-335. Epub 2018 Nov 22.

Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, RI 02903, United States of America. Electronic address:

SHP2 is a ubiquitously expressed protein tyrosine phosphatase, which is involved in many signaling pathways to regulate the skeletal development. In endochondral ossification, SHP2 is known to modify the osteogenic fate of osteochondroprogenitors and to impair the osteoblastic transdifferentiation of hypertrophic chondrocytes. However, how SHP2 regulates osteoblast differentiation in intramembranous ossification remains incompletely understood. Read More

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November 2018
4 Reads

Skeletal Manifestations of Hypoparathyroidism.

Authors:
Mishaela R Rubin

Bone 2018 Nov 19. Epub 2018 Nov 19.

Metabolic Bone Disease Unit, Columbia University College of P&S, PH8W-864, 630 W. 168th St, New York, NY 10032, United States of America. Electronic address:

Chronic PTH deficiency has a marked effect on the skeleton, leading to characteristic decreases in bone remodeling and increases in bone mass. An effect on fracture risk has not been demonstrated, although biochemical, imaging, and histomorphometric data indicate abnormalities in skeletal properties. Replacement with PTH leads to a new skeletal state that is maintained with long-term treatment. Read More

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November 2018
3 Reads

Pregnancy supplementation of Gambian mothers with calcium carbonate alters mid-childhood IGF1 in a sex-specific manner.

Bone 2018 Nov 19;120:314-320. Epub 2018 Nov 19.

Medical Research Council Keneba, MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, P.O. Box 273, The Gambia; Department of Women and Children's Health, King's College London, London SE1 7EH, United Kingdom.

Context: Sex-specific effects of pregnancy calcium carbonate supplementation have been reported in 8-12 year old Gambian children, indicating faster growth in boys but slower growth in girls born to calcium-supplemented mothers.

Objective: To determine whether the pregnancy supplement resulted in sex-specific effects on offspring IGF1 and other growth-related indices in mid-childhood.

Design: Analysis of archived data obtained in mid-childhood from the children of rural Gambian mothers who had been randomised to 1500 mgCa/d (Ca) or placebo (P) from 20 weeks pregnancy to delivery (ISRCTN96502494). Read More

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November 2018
3 Reads

Bone remodeling following MR-guided focused ultrasound: Evaluation with HR-pQCT and FTIR.

Bone 2018 Nov 16;120:347-353. Epub 2018 Nov 16.

Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107-5705, United States.

Magnetic resonance-guided focused ultrasound (MRgFUS) is a novel non-invasive ablation technique that uses focused sound energy to destroy focal tumors, primarily via heat deposition. It is widely used for palliation of pain from bone metastases and has also recently gained popularity as a technique for ablation of benign bone tumors and facet degenerative joint disease (rhizotomy). Clinically, in a subset of patients who have undergone MRgFUS of bone, a variety of treatment responses have been noted on follow-up imaging, including focal sclerosis within the target lesion or more exuberant proliferative changes associated with the periosteum. Read More

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November 2018
2 Reads

Association of bone mineral density with hemoglobin and change in hemoglobin among older men and women: The Cardiovascular Health Study.

Bone 2018 Nov 15;120:321-326. Epub 2018 Nov 15.

Division of Endocrinology, Stanford University School of Medicine, Stanford, CA, United States of America. Electronic address:

Purpose: Osteoblasts and their precursors support hematopoiesis in the bone marrow. We hypothesized that declines in Hgb levels are associated with bone mineral density (BMD).

Methods: The Cardiovascular Health Study is a prospective longitudinal study that enrolled 5888 community-dwelling adults aged >65 years and measured hemoglobin twice, in 1989-90 and 1992-93, as well as BMD by dual-energy X-ray absorptiometry (DXA) in 1994-95. Read More

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November 2018
5 Reads

Lamin B receptor-related disorder is associated with a spectrum of skeletal dysplasia phenotypes.

Bone 2018 Nov 15;120:354-363. Epub 2018 Nov 15.

Department of Pediatrics, Division of Medical Genetics, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

LBR (Lamin B Receptor) encodes a bifunctional protein important for cholesterol biosynthesis and heterochromatin organization on the inner nuclear membrane. Pathogenic variants in LBR are associated with marked phenotypic variability, ranging from the benign Pelger-Huët anomaly to lethal Greenberg Dysplasia. We performed trio exome sequencing (ES) on two patients with atypical variants of skeletal dysplasia and their unaffected parents. Read More

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November 2018
13 Reads

Prediction of early metastatic disease in experimental breast cancer bone metastasis by combining PET/CT and MRI parameters to a Model-Averaged Neural Network.

Bone 2018 Nov 13;120:254-261. Epub 2018 Nov 13.

Department of Radiology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany. Electronic address:

Macrometastases in bone are preceded by bone marrow invasion of disseminated tumor cells. This study combined functional imaging parameters from FDG-PET/CT and MRI in a rat model of breast cancer bone metastases to a Model-averaged Neural Network (avNNet) for the detection of early metastatic disease and prediction of future macrometastases. Metastases were induced in 28 rats by injecting MDA-MB-231 breast cancer cells into the right superficial epigastric artery, resulting in the growth of osseous metastases in the right hind leg of the animals. Read More

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November 2018
3 Reads

Innervation of the tibial epiphysis through the intercondylar foramen.

Bone 2018 Nov 13;120:297-304. Epub 2018 Nov 13.

Electron Microscope Laboratory, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

The periosteum and mineralized bone are innervated by nerves that sense pain. These include both myelinated and unmyelinated neurons with either free nerve endings or bearing nociceptors. Parasympathetic and sympathetic autonomic nerves also innervate bone. Read More

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November 2018
4 Reads

Correlations between gene expression and mineralization in the avian leg tendon.

Bone 2018 Nov 9. Epub 2018 Nov 9.

Department of Polymer Science, University of Akron, Akron, OH, USA. Electronic address:

Certain avian tendons have been studied previously as a model system for normal mineralization of vertebrates in general. In this regard, the gastrocnemius tendon in the legs of turkeys mineralizes in a well-defined temporal and spatial manner such that changes in the initial and subsequent events of mineral formation can be associated with time and specific locations in the tissue. In the present investigation, these parameters and mineral deposition have been correlated with the expression of several genes and the synthesis and secretion of their related extracellular matrix proteins by the composite tenocytes of the tendon. Read More

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November 2018

Deletion of nicotinic acetylcholine receptor alpha9 in mice resulted in altered bone structure.

Bone 2018 Nov 7;120:285-296. Epub 2018 Nov 7.

Experimental Trauma Surgery, Justus-Liebig-University Giessen, Aulweg 128, 35392 Giessen, Germany. Electronic address:

Alterations in bone strength and structure were found in knockout (KO) mouse strains with deletion of several acetylcholine receptors. Interestingly, the expression of the nicotinic acetylcholine receptors (nAChR) subunit α10 was down-regulated in osteogenic differentiated mesenchymal stem cells of patients with osteoporosis whereas the expression of subunit α9 was not altered. Since nAChR subunits α9 and α10 are often combined in a functional receptor, we analyzed here the bone of adult female KO mice with single deletion of either nAChR alpha9 (α9KO) or alpha10 (α10KO). Read More

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November 2018
4 Reads

Estrogen depletion alters mineralization regulation mechanisms in an ovariectomized monkey animal model.

Bone 2018 Nov 7;120:279-284. Epub 2018 Nov 7.

Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Department of Biomedical Engineering, Indiana University-Purdue University, Indianapolis (IUPUI), Indianapolis, IN 46202, USA.

Ovariectomized animal models have been extensively used in osteoporosis research due to the resulting loss of bone mass. The purpose of the present study was to test the hypothesis that estrogen depletion alters mineralization regulation mechanisms in an ovariectomized monkey animal model. To achieve this we used Raman microspectroscopy to analyze humeri from monkeys that were either SHAM-operated or ovariectomized (N = 10 for each group). Read More

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November 2018
1 Read

Induction of Lrp5 HBM-causing mutations in Cathepsin-K expressing cells alters bone metabolism.

Bone 2018 Oct 25;120:166-175. Epub 2018 Oct 25.

Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA; Department of Biomedical Engineering, Indiana University-Purdue University at Indianapolis, Indianapolis, IN, USA. Electronic address:

High-bone-mass (HBM)-causing missense mutations in the low density lipoprotein receptor-related protein-5 (Lrp5) are associated with increased osteoanabolic action and protection from disuse- and ovariectomy-induced osteopenia. These mutations (e.g. Read More

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October 2018
3 Reads

Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis.

Bone 2018 Oct 25. Epub 2018 Oct 25.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA. Electronic address:

Vertebrate teeth are attached to the jawbones using a variety of methods but in mammals, a fibrous connection is the norm. This fibrous periodontal ligament (PDL) allows teeth to move in the jawbones in response to natural eruptive forces, mastication, and orthodontic tooth movement. In some disease states the PDL either calcifies or is replaced by a mineralized tissue and the result is ankylosis, where the tooth is fused to the alveolar bone. Read More

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October 2018
2 Reads

Bone and muscle specific circulating microRNAs in postmenopausal women based on osteoporosis and sarcopenia status.

Bone 2018 Nov 5;120:271-278. Epub 2018 Nov 5.

Department of Health and Exercise Science, University of Oklahoma, 1401 Asp Avenue, Norman, OK 73019, USA.

MicroRNAs (miRNAs) are short, non-coding RNA molecules that fine tune posttranscriptional protein expression. Aging is accompanied by progressive declines in muscle mass and strength, and in bone mineral density (BMD). Although miRNAs in pathology have been extensively studied, the role of circulating miRNAs (c-miRNAs) in osteoporosis and sarcopenia has to date not been well understood. Read More

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November 2018
5 Reads

Use it or lose it to age: A review of bone and muscle communication.

Authors:
Lynda Bonewald

Bone 2018 Nov 5;120:212-218. Epub 2018 Nov 5.

Indiana University, United States of America. Electronic address:

Until recently, it was assumed that the only interaction between muscle and bone is mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism. A relatively new concept is that muscle, especially contracted muscle, acts as a secretory organ, regulating metabolism. An even newer concept is that bone, especially the osteocytes in bone, act as endocrine cells targeting other organs such as kidney and more recently, muscle. Read More

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November 2018
5 Reads

Phenotyping and genotyping of skeletal dysplasias: Evolution of a center and a decade of experience in India.

Bone 2018 Nov 6;120:204-211. Epub 2018 Nov 6.

Department of Medical Genetics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India. Electronic address:

Genetic heterogeneity, high burden and the paucity of genetic testing for rare diseases challenge genomic healthcare for these disorders in India. Here we report our experience over the past decade, of establishing the genomic evaluation of skeletal dysplasia at a tertiary university hospital in India. Research or clinical genomic testing was carried out by Sanger sequencing and next-generation sequencing. Read More

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November 2018
2 Reads

Bone collagen network integrity and transverse fracture toughness of human cortical bone.

Bone 2018 Oct 28;120:187-193. Epub 2018 Oct 28.

Vanderbilt University Medical Center, Nashville, TN, United States of America. Electronic address:

Greater understanding of the determinants of skeletal fragility is highly sought due to the great burden that bone affecting diseases and fractures have on economies, societies and health care systems. Being a complex, hierarchical composite of collagen type-I and non-stoichiometric substituted hydroxyapatite, bone derives toughness from its organic phase. In this study, we tested whether early observations that a strong correlation between bone collagen integrity measured by thermomechanical methods and work to fracture exist in a more general and heterogeneous sampling of the population. Read More

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October 2018
7 Reads

Sphenoid bone hypoplasia is a skeletal phenotype of cleidocranial dysplasia in a mouse model and patients.

Bone 2018 Nov 2;120:176-186. Epub 2018 Nov 2.

Tokyo Dental College Research Branding Project, Tokyo Dental College, Tokyo, Japan; Oral Health Science Center, Tokyo Dental College, Tokyo, Japan. Electronic address:

Cleidocranial dysplasia (CCD) is an autosomal dominant disorder caused by heterozygous mutations in RUNX2. Affected individuals exhibit delayed maturation or hypoplasia in various bones, mainly including those formed by intramembranous ossification. Although several reports described deformation of the sphenoid bone in CCD patients, details of the associated changes have not been well documented. Read More

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November 2018
2 Reads

Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones.

Bone 2018 Oct 30;120:219-231. Epub 2018 Oct 30.

Department of Molecular Endocrinology, National Research Institute of Child Health and Development, Tokyo 157-8535, Japan.

A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such genes contributes to the cell lineage commitment and subsequent differentiation via epigenetic chromatin modification and remodeling. However, it is unclear which cell lineage and gene sets are targeted by polycomb proteins during skeletal growth. Read More

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October 2018
1 Read

SF-deferoxamine, a bone-seeking angiogenic drug, prevents bone loss in estrogen-deficient mice.

Bone 2018 Oct 30;120:156-165. Epub 2018 Oct 30.

Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China. Electronic address:

Deferoxamine (DFO) possesses a good chelating capability and is therefore used for the clinical treatment of ion deposition diseases. Increasing evidence shows that DFO can inhibit the activity of proline hydroxylase (PHD) by chelating iron, resulting in hypoxia-induced factor (HIF) signaling activation and angiogenesis promotion. However, clinical evidence indicates that a high concentration of DFO could be biotoxic due to its enrichment in related organs. Read More

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October 2018
3 Reads

Letter to the editor: The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats.

Bone 2018 Oct 24. Epub 2018 Oct 24.

Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

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October 2018

Bone mineral density response rates are greater in patients treated with abaloparatide compared with those treated with placebo or teriparatide: Results from the ACTIVE phase 3 trial.

Bone 2018 Oct 22;120:137-140. Epub 2018 Oct 22.

Nordic Bioscience, Copenhagen, Denmark.

Background: Abaloparatide is a 34-amino acid peptide that selectively binds to the RG conformation of the parathyroid hormone receptor type 1. It was developed for the treatment of women with postmenopausal osteoporosis at high risk of fracture. In ACTIVE, an 18-month phase 3 study (NCT01343004), abaloparatide increased bone mineral density (BMD), decreased the risk of vertebral and nonvertebral fractures compared with placebo, and decreased the risk of major osteoporotic fractures compared with placebo and teriparatide. Read More

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October 2018
9 Reads

Administration of teriparatide for four years cyclically compared to two years daily in treatment Naïve and alendronate treated women.

Bone 2018 Oct 21;120:246-253. Epub 2018 Oct 21.

Regional Bone and Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, NY 10993, United States of America; Department of Medicine, Columbia University, New York, NY 10032, United States of America.

Purpose: We evaluated if equivalent doses of TPTD given cyclically over 4-years could increase BMD >2-years of daily TPTD in 2 cohorts of women; previously untreated (Rx-Naïve) and women previously treated with ALN (ALN-Rx).

Methods: In Rx-Naïve, women were randomized to daily TPTD for 24 months (Daily; n = 23) or cyclic TPTD for 48 months (3 months on, 3 months off; Cyclic; n = 25). In ALN-Rx, women were randomized to continued ALN plus daily TPTD for 24 months, followed by ALN alone for 24 months (Daily; n = 21) or TPTD for 48 months (3 months on, 3 months off) while ALN was continued (Cyclic; n = 20). Read More

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October 2018

Frequency and duration of vigorous physical activity bouts are associated with adolescent boys' bone mineral status: A cross-sectional study.

Bone 2018 Oct 22;120:141-147. Epub 2018 Oct 22.

Institute of Sport Pedagogy and Coaching Sciences, Centre of Behavioral, Social and Health Sciences, University of Tartu, Tartu, Estonia.

Purpose: Vigorous physical activity (VPA) has been proven to promote osteogenesis in adolescents; however the specifics of the optimal pattern of frequency and duration of VPA are unknown. The main goal of the present study was to analyze the associations of different length of VPA bouts with bone health.

Methods: 180 healthy male adolescents (11-13 years) had their bone mineral content and density assessed by dual-energy X-ray absorptiometry scans at the whole body, femoral neck (FN) and lumbar spine and their physical activity measured by an accelerometer during one week. Read More

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October 2018
7 Reads

Abaloparatide, a novel osteoanabolic PTHrP analog, increases cortical and trabecular bone mass and architecture in orchiectomized rats by increasing bone formation without increasing bone resorption.

Bone 2018 Oct 19;120:148-155. Epub 2018 Oct 19.

Radius Health, Waltham, MA, USA.

Male osteoporosis can occur with advanced age and with hypogonadism, with increased bone resorption and/or inadequate bone formation contributing to reduced bone mass and increased fracture risk. Abaloparatide is a selective PTH receptor agonist that increases bone formation and bone mass in postmenopausal women with osteoporosis and in estrogen-deficient animals. The current study evaluated the effects of abaloparatide in orchiectomized (ORX) rats, a model of male osteoporosis. Read More

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October 2018
2 Reads

Tissue nonspecific alkaline phosphatase promotes calvarial progenitor cell cycle progression and cytokinesis via Erk1,2.

Bone 2018 Oct 17;120:125-136. Epub 2018 Oct 17.

Department of Orthodontics and Pediatric Dentistry, School of Dentistry, 1011 N University Avenue, University of Michigan, Ann Arbor, MI 48109-1078, USA. Electronic address:

Bone growth is dependent upon the presence of self-renewing progenitor cell populations. While the contribution of Tissue Nonspecific Alkaline Phosphatase (TNAP) enzyme activity in promoting bone mineralization when expressed in differentiated bone forming cells is well understood, little is known regarding the role of TNAP in bone progenitor cells. We previously found diminished proliferation in the calvarial MC3T3E1 cell line upon suppression of TNAP by shRNA, and in calvarial cells and tissues of TNAP mice. Read More

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October 2018
4 Reads

QCT of the femur: Comparison between QCTPro CTXA and MIAF Femur.

Bone 2018 Oct 17;120:262-270. Epub 2018 Oct 17.

Institute of Medical Physics, University of Erlangen, Erlangen, Germany; Dept of Medicine 3, University Hospital Erlangen, Germany. Electronic address:

QCT is commonly employed in research studies and clinical trials to measure BMD at the proximal femur. In this study we compared two analysis software options, QCTPro CTXA and MIAF-Femur, using CT scans of the semi-anthropometric European Proximal Femur Phantom (EPFP) and in vivo data from 130 Chinese elderly men and women aged 60-80 years. Integral (Int), cortical (Cort) and trabecular (Trab) vBMD, volume, and BMC of the neck (FN), trochanter (TR), inter-trochanter (IT), and total hip (TH) VOIs were compared. Read More

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October 2018
5 Reads

Systemic bone loss, impaired osteogenic activity and type I muscle fiber atrophy in mice with elastase-induced pulmonary emphysema: Establishment of a COPD-related osteoporosis mouse model.

Bone 2018 Oct 17;120:114-124. Epub 2018 Oct 17.

Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

Although it is suggested that chronic obstructive pulmonary disease (COPD) and bone are related, almost all of the pathological mechanisms of COPD-related osteoporosis remain unknown. There is a mouse model showing a deterioration of bone quality after cigarette smoke exposure; however, in smoking exposure models, various factors exist that affect bone metabolism, such as smoking and body weight loss (muscle and fat mass loss). We considered it appropriate to use an elastase-induced emphysema model to exclude factors influencing bone metabolism and to investigate the influence of pulmonary emphysema on bone metabolism. Read More

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October 2018
1 Read

Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate.

Bone 2018 Oct 16;120:101-113. Epub 2018 Oct 16.

São Paulo State University (UNESP), School of Dentistry, Department of Surgery and Integrated Clinic, Rua José Bonifácio, 1193, CEP 16015-050, Araçatuba, SP, Brazil; Group for the Research and Study of Laser in Dentistry, São Paulo State University (UNESP), School of Dentistry, Rua José Bonifácio, 1193, CEP 16015-050, Araçatuba, SP, Brazil.

This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Senile rats received 0.45 ml of vehicle (VEH and VEH/aPDT) or 0. Read More

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October 2018
5 Reads

Mendelian randomization in the bone field.

Bone 2018 Oct 12. Epub 2018 Oct 12.

MRC Biostatistics Unit, University of Cambridge, United Kingdom; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

Identification of causative risk factors amenable for modification is essential for the prevention and treatment of osteoporosis. Observational studies have identified associations between several potentially modifiable risk factors and osteoporosis. However, observational studies are susceptible to confounding, reverse causation bias, and measurement error, all of which limit their ability to provide causal estimates of the effect of exposures on outcomes, thereby reducing their ability to inform prevention and treatment strategies against bone loss and fractures. Read More

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October 2018
7 Reads

The genetics of vitamin D.

Bone 2018 Oct 12. Epub 2018 Oct 12.

Program in Genetic Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Brookline, Boston 02115, USA.

Vitamin D plays an essential role in human health as it influences immune function, cell proliferation, differentiation and apoptosis. Vitamin D deficiency has been associated with numerous health outcomes, including bone disease, cancer, autoimmune disease, cardiovascular conditions and more. However, the causal role of vitamin D beyond its importance for bone health remains unclear and is under much debate. Read More

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October 2018
2 Reads

Bone matrix hypermineralization associated with low bone turnover in a case of Nasu-Hakola disease.

Bone 2018 Oct 10. Epub 2018 Oct 10.

Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling,, 1st Med. Dept. Hanusch Hospital, Vienna, Austria; Orthopedic Hospital of Speising, Pediatric Department, Vienna, Austria.

Analysis of tissue from a 34-years-old male patient from Austrian origin with a history of multiple fractures associated with painful episodes over the carpal, tarsal and at the end of the long bones respectively is presented. Radiographic images and axial 3DCT scans showed widespread defects in trabecular bone architecture and ill-defined cortices over these skeletal sites in the form of discrete cystic-like lesions. Family history indicated two sisters (one half and one full biological sisters) also with a history of fractures. Read More

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October 2018
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Changes in bone matrix properties with aging.

Authors:
David B Burr

Bone 2018 Oct 10;120:85-93. Epub 2018 Oct 10.

Dept. of Anatomy and Cell Biology, Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, United States of America; Dept. of Biomedical Engineering, Indiana University-Purdue University, Indianapolis (IUPUI), United States of America. Electronic address:

It is well known that bone loss accompanies aging in both men and women and contributes to skeletal fragility in the older population, but changes that occur to the bone tissue matrix itself are less well known. These changes in bone quality aggravate the skeletal fragility associated with loss of bone mass. Bone tissue quality is affected by age-related changes in bone mineral, collagen and its cross-linking profiles, water compartments and even non-collagenous proteins. Read More

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October 2018
8 Reads

Findings as a starting point to unravel the underlying mechanisms of in vivo interactions involving Wnt10a in bone, fat and muscle.

Bone 2018 Oct 11;120:75-84. Epub 2018 Oct 11.

Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health University, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

Wnt10a is a member of the WNT family. Although deficiency of this gene causes symptoms related to teeth, hair, nails, and skin, we recently demonstrated a new phenotype of Wnt10a knockout (KO) mice involving bone and fat. The in vivo effect of the Wnt10a gene on bone and fat is unclear, and the relationship between bone/fat and muscle in Wnt10a signaling is also interesting. Read More

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October 2018
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Lowering iron level protects against bone loss in focally irradiated and contralateral femurs through distinct mechanisms.

Bone 2018 Oct 7;120:50-60. Epub 2018 Oct 7.

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, China. Electronic address:

Radiation therapy leads to increased risk of late-onset fragility and bone fracture due to the loss of bone mass. On the other hand, iron overloading causes osteoporosis by enhancing bone resorption. It has been shown that total body irradiation increases iron level, but whether the systemic bone loss is related to the changes in iron level and hepcidin regulation following bone irradiation remains unknown. Read More

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October 2018
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Epigenetic dynamic during endochondral ossification and articular cartilage development.

Bone 2018 Oct 6. Epub 2018 Oct 6.

Normandie Univ, UNICAEN, EA7451 BioConnecT, Caen, France. Electronic address:

Within the last decade epigenetics has emerged as fundamental regulator of numerous cellular processes, including those orchestrating embryonic and fetal development. As such, epigenetic factors play especially crucial roles in endochondral ossification, the process by which bone tissue is created, as well during articular cartilage formation. In this review, we summarize the recent discoveries that characterize how DNA methylation, histone post-translational modifications and non-coding RNA (e. Read More

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October 2018
7 Reads

Denosumab effects on bone density and turnover in postmenopausal women with low bone mass with or without previous treatment.

Bone 2018 Oct 4;120:44-49. Epub 2018 Oct 4.

Department of Endocrinology, 424 General Military Hospital, 54638 Thessaloniki, Greece. Electronic address:

Purpose: Prior osteoporosis therapies may affect the skeletal response to denosumab. We compared the effect of denosumab (60 mg every 6 months for 12 months) on bone mineral density and bone metabolism parameters in postmenopausal women with low bone mass who were either treatment-naïve (n = 30), or previously treated either with zoledronic acid (n = 30), or teriparatide (n = 22).

Methods: We assessed lumbar spine bone mineral density (BMD) and measured serum concentrations of the bone turnover markers pro-collagen type 1 N-terminal propeptide (PINP) and C-terminal-cross-linking telopeptide of type 1 collagen (CTX), as well as sclerostin, dickkopf-1 (Dkk-1), and myostatin. Read More

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October 2018
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Associations of dietary protein intake with bone mineral density: An observational study in 70,215 UK Biobank participants.

Bone 2018 Oct 4;120:38-43. Epub 2018 Oct 4.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address:

Purpose: Adequate dietary protein intake is important for the maintenance of bone health; however, data in this area is ambiguous with some suggestion that high protein intake can have deleterious effects on bone health. The aim of the current study was to explore the associations of protein intake with bone mineral density (BMD).

Methods: We used baseline data from the UK Biobank (participants aged 40-69 years) to examine the association of protein intake with BMD (measured by ultrasound). Read More

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October 2018
1 Read