7,582 results match your criteria Bone[Journal]


Treatment with an inhibitor of fatty acid synthase attenuates bone loss in ovariectomized mice.

Bone 2019 Feb 16. Epub 2019 Feb 16.

Sydney Medical School Nepean, The University of Sydney, Penrith, NSW 2750, Australia; Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St Albans, VIC 3021, Australia; Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St Albans, VIC 3021, Australia. Electronic address:

Bone and fat cells have an antagonistic relationship. Adipocytes exert a toxic effect on bone cells in vitro through the secretion of fatty acids, which are synthesized by fatty acid synthase (FAS). Inhibition of FAS in vitro rescues osteoblasts from fat-induced toxicity and cell death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.017DOI Listing
February 2019

Using mouse genetics to understand human skeletal disease.

Bone 2019 Feb 15. Epub 2019 Feb 15.

Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Australia, Sydney, NSW, 2010, Australia; University of Notre Dame Australia, Sydney, NSW, 2010, Australia.

Technological advances have enabled the study of the human genome in incredible detail with relative ease. However, our ability to interpret the functional significance of the millions of genetic variants present within each individual is limited. As a result, the confident assignment of disease-causing variant calls remains a significant challenge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.015DOI Listing
February 2019

Subregional areal bone mineral density (aBMD) is a better predictor of heterogeneity in trabecular microstructure of vertebrae in young and aged women than subregional trabecular bone score (TBS).

Bone 2019 Feb 15. Epub 2019 Feb 15.

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Germany; Laboratory for Anthropology and Skeletal Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Serbia.

Background: Currently, bone densitometry fails to identify nearly half of those elderly patients at immediate fracture risk. To improve clinical assessment of vertebral fracture risk, we aimed to determine how the DXA-based 2D parameter Trabecular Bone Score (TBS) relates to subregional variability in 3D trabecular microstructure in young and elderly women compared to aBMD.

Methods: T12 vertebrae from 29 women (11 young: 32 ± 6 years, 18 aged: 71 ± 5 years) were DXA-scanned ex vivo in anterior-posterior (AP) and lateral projection providing vertebral aBMD and TBS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.014DOI Listing
February 2019

Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells.

Bone 2019 Feb 15. Epub 2019 Feb 15.

Department of Oncology and Metabolism, Medical School, University of Sheffield, UK. Electronic address:

Multiple myeloma (MM) is characterised by destructive lytic bone disease, caused by induction of bone resorption and impaired bone formation. Our understanding of the molecular mechanisms responsible for osteoblast suppression, are limited. Using the 5T2MM murine model of MM we have previously shown that suppression of the activity of a known inhibitor of bone formation Dikkopf-1 (Dkk1) prevents the development of lytic bone disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.012DOI Listing
February 2019

Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis.

Bone 2019 Feb 14. Epub 2019 Feb 14.

IRCCS Istituto Ortopedico Rizzoli, Laboratory of Preclinical and Surgical Studies, Bologna, Italy.

MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of miRNA actions and their targets has helped to identify them as novel regulations actors in bone. Various studies have shown that miRNA deregulation mediates the progression of bone-related pathologies, such as osteoporosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.013DOI Listing
February 2019

Rickets severity predicts clinical outcomes in children with X-linked hypophosphatemia: Utility of the radiographic Rickets Severity Score.

Bone 2019 Feb 14. Epub 2019 Feb 14.

Yale University School of Medicine, New Haven, CT, USA.

The Rickets Severity Score (RSS) was used to evaluate X-linked hypophosphatemic rickets (XLH), a genetic disorder mediated by increased circulating FGF23. The reliability of the RSS was assessed using data from a randomized, phase 2 clinical trial that evaluated the effects of burosumab, a fully human anti-FGF23 monoclonal antibody, in 52 children with XLH ages 5 to 12 years. Bilateral knee and wrist radiographs were obtained at baseline, week 40, and week 64. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.010DOI Listing
February 2019

Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin.

Bone 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathophysiology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan; Division of Laboratory Animal Research, Advanced Research Support Center, Ehime University, Toon, Ehime, Japan; Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, Toon, Ehime, Japan. Electronic address:

Zinc finger and SCAN domain containing 10 (Zscan10) was identified as a novel transcription factor that is involved in osteoclast differentiation in our previous report. However, the biological functions of Zscan10 are not fully understood except its roles in the maintenance of genome stability and pluripotency of embryonic stem cells. Therefore, the purpose of this study was to clarify the function of Zscan10 in somatic cells, especially during osteoclast differentiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.011DOI Listing
February 2019

Using zebrafish to study skeletal genomics.

Bone 2019 Feb 11. Epub 2019 Feb 11.

The Musculoskeletal Genetics Laboratory, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel; Hebrew SeniorLife, Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, USA. Electronic address:

While genome-wide association studies (GWAS) have revolutionized our understanding of the genetic architecture of skeletal diseases, animal models are required to identify causal mechanisms and to translate underlying biology into new therapies. Despite large-scale knockout mouse phenotyping efforts, the skeletal functions of most genes residing at GWAS-identified loci remain unknown, highlighting a need for complementary model systems to accelerate gene discovery. Over the past several decades, zebrafish (Danio rerio) has emerged as a powerful system for modeling the genetics of human diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.009DOI Listing
February 2019

A scoring assessment tool for the risk of vertebral fractures in patients with type 2 diabetes mellitus.

Bone 2019 Feb 11. Epub 2019 Feb 11.

Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane 693-8501, Japan. Electronic address:

Background: Development of assessment tool for fracture risk is an urgent task, because bone mineral density (BMD) is less useful for evaluating fracture risk in type 2 diabetes mellitus (T2DM).

Subjects And Methods: In total, 808 T2DM patients were enrolled in this cross-sectional study. To develop a scoring assessment tool using clinical risks for vertebral fracture (VF), we evaluated which variables were associated with VF by logistic regression analysis, and categorized these variables based on cut-off values obtained by using receiver operating characteristic (ROC) curves. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.003DOI Listing
February 2019

High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT.

Bone 2019 Feb 8;122:14-21. Epub 2019 Feb 8.

Department of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.

Purpose: Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not been studied in Norwegian patients with fragility fractures. The objectives of this study were to examine the clinical characteristics of a cohort of women and men with fragility fractures, their prevalence of vertebral fractures using VFA and prevalence of low TBS, and explore the differences between the sexes and patients with and without vertebral fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.008DOI Listing
February 2019
1 Read

Changes in the osteocyte lacunocanalicular network with aging.

Bone 2019 Feb 8. Epub 2019 Feb 8.

Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO 64108, United States of America. Electronic address:

Osteoporosis is an aging-related disease of reduced bone mass that is particularly prevalent in post-menopausal women, but also affects the aged male population and is associated with increased fracture risk. Osteoporosis is the result of an imbalance whereby bone formation by osteoblasts no longer keeps pace with resorption of bone by osteoclasts. Osteocytes are the most abundant cells in bone and, although previously thought to be quiescent, they are now known to be active, multifunctional cells that play a key role in the maintenance of bone mass by regulating both osteoblast and osteoclast activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.025DOI Listing
February 2019
1 Read

Effects of pH alteration on the pathogenesis of medication-related osteonecrosis of the jaw.

Bone 2019 Feb 7. Epub 2019 Feb 7.

Department of Oral and Maxillofacial Surgery, Ewha Womans University Medical Center, Seoul, Republic of Korea; Research Institute for Intractable Osteonecrosis of the Jaw, School of Medicine, Ewha Womans University, Seoul, Republic of Korea. Electronic address:

Introduction: An acidic environment has been recognized to increase catabolic activities and inhibit osteoblastic deposition, and also exhibited in the pathogenesis of various bone diseases. The aim of the study was to investigate the role of systemic and local pH alteration in the pathogenesis of medication-related osteonecrosis of the jaw (MRONJ).

Material And Methods: Initially, MRONJ was induced in 54 Sprague-Dawley rats via subcutaneous bisphosphonate injections, once a week for 8 weeks. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282193004
Publisher Site
http://dx.doi.org/10.1016/j.bone.2019.02.007DOI Listing
February 2019
2 Reads

Effects of parathyroidectomy on the biology of bone tissue in patients with chronic kidney disease and secondary hyperparathyroidism.

Bone 2019 Feb 6;121:277-283. Epub 2019 Feb 6.

LIM 16 - Laboratorio de Fisiopatologia Renal, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Hospital Samaritano Americas Serviços Medicos, Sao Paulo, SP, Brazil. Electronic address:

Secondary hyperparathyroidism is a complication of chronic kidney disease that compromises skeletal integrity. In patients with secondary hyperparathyroidism undergoing parathyroidectomy, parathyroid hormone levels dramatically decrease. The effects of parathyroidectomy on bone tissue are poorly understood, especially regarding the proteins expressed by osteocytes, such as fibroblast growth factor 23, dentin matrix protein 1, matrix extracellular phosphoglycoprotein, sclerostin, receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin, which regulate bone turnover. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.029DOI Listing
February 2019
1 Read

Sirtuins and FoxOs in osteoporosis and osteoarthritis.

Bone 2019 Feb 6. Epub 2019 Feb 6.

Department of Medicine, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Department of Orthopedics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

The sirtuin family of NAD-dependent protein deacetylases promotes longevity and counteract age-related diseases. One of the major targets of Sirtuins are the FoxO family of transcription factors. FoxOs play a major role in the adaptation of cells to a variety of stressors such as oxidative stress and growth factor deprivation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.018DOI Listing
February 2019
1 Read

Bone mass development is sensitive to insulin resistance in adolescent boys.

Bone 2019 Feb 7;122:1-7. Epub 2019 Feb 7.

Hans Christian Andersen Children's Hospital, Odense University Hospital, Kløvervænget 23C, 5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3, 5000 Odense C, Denmark; Department of Nutrition, Exercise and Sports, University of Copenhagen, Nørre Allé 51, 2200 København N, Denmark.

Purpose: Insulin resistance may exert a negative influence on bone mass in childhood and adolescence. The objective was to assess the association between insulin resistance and total body less head (TBLH) bone mineral content (BMC) and to investigate whether body composition, physical activity or osteocalcin levels may influence this association.

Methods: A longitudinal study with follow-up over more than 6 years was performed and included 562 apparently healthy participants with a mean age of 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.005DOI Listing
February 2019
2 Reads

Advanced glycation end-product 2 and Porphyromonas gingivalis lipopolysaccharide increase sclerostin expression in mouse osteocyte-like cells.

Bone 2019 Feb 5;122:22-30. Epub 2019 Feb 5.

Department of Periodontology and Endodontology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

Sclerostin is a secreted glycoprotein that is mainly expressed in osteocytes, exerts negative effects on bone formation, and is present at elevated levels in diabetes mellitus (DM). Periodontitis is an infectious disease caused by periodontopathic bacteria, a complication of DM, and sometimes associated with severe inflammation and alveolar bone resorption. Advanced glycation end-products (AGEs) are a major pathogen in DM complications and adversely influence periodontitis in DM patients. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282193004
Publisher Site
http://dx.doi.org/10.1016/j.bone.2019.02.001DOI Listing
February 2019
3 Reads

Skeletal responses to an all-female unassisted Antarctic traverse.

Bone 2019 Feb 5;121:267-276. Epub 2019 Feb 5.

Army Personnel Research Capability, Army Headquarters, Andover, UK. Electronic address:

Purpose: To investigate the skeletal effects of the first all-female trans-Antarctic traverse.

Methods: Six women (mean ± SD, age 32 ± 3 years, height 1.72 ± 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.002DOI Listing
February 2019

Senescent and apoptotic osteocytes and aging: Exercise to the rescue?

Bone 2019 Feb 6;121:255-258. Epub 2019 Feb 6.

Tufts University School of Medicine, Maine Medical Center Research Institute Scarborough, ME, United States of America.

Osteocytes are the most prevalent cell in the skeleton and are the master regulator of bone remodeling. Despite the understanding that osteocytes have a multiyear lifespan, and some factors induce apoptosis in osteocytes, much less is understood about the induction and consequences of osteocyte senescence. Filling these gaps in knowledge will provide novel approaches to slowing age-related bone loss and preventing fragility fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.006DOI Listing
February 2019

Intermittent PTH treatment improves bone and muscle in glucocorticoid treated Mdx mice: A model of Duchenne Muscular Dystrophy.

Bone 2019 Feb 1;121:232-242. Epub 2019 Feb 1.

Department of Pharmacology and Toxicology, University of Toronto, ON, Canada. Electronic address:

Duchenne Muscular Dystrophy (DMD) is a progressive muscle disorder caused by genetic mutations of the dystrophin encoding gene. In the absence of functional dystrophin, DMD patients suffer from muscle inflammation and wasting, as well as compromised bone health with increased risk of fracture. The use of high dose glucocorticoids (GC) as the standard therapy also contributes to bone fragility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.028DOI Listing
February 2019
4 Reads

Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls.

Bone 2019 Jan 31;121:221-226. Epub 2019 Jan 31.

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America; Department of Genetics, University of Pennsylvania, Philadelphia, PA, United States of America; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America. Electronic address:

Over the past two decades, a low frequency variant (rs1800012) within the first intron of the type I collagen alpha 1 (COLIA1) gene has been implicated in lower areal BMD (aBMD) and increased risk of osteoporotic fracture. This association is particularly strong in postmenopausal women, in whom net bone loss arises in the context of high bone turnover. High bone turnover also accompanies childhood linear growth; however, the role of rs1800012 in this stage of net bone accretion is less well understood. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282193003
Publisher Site
http://dx.doi.org/10.1016/j.bone.2019.01.026DOI Listing
January 2019
4 Reads

Response to: Letter to the editor: The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats.

Authors:
Shereen N Raafat

Bone 2019 Mar;120:534

Department of Pharmacology and Toxicology, Faculty of Dentistry, British University in Egypt. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.007DOI Listing

Retraction notice to "Homocysteine as a predictive factor for hip fracture in stroke patients" Bone, Volume 36, Issue 4, April 2005, Pages 721-726.

Bone 2019 03;120:522

Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.012DOI Listing
March 2019
1 Read

Long-term childhood body mass index and adult bone mass are linked through concurrent body mass index and body composition.

Bone 2019 Jan 30;121:259-266. Epub 2019 Jan 30.

Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address:

Body mass plays a crucial role in the bone growth and development, but few studies have examined the association of long-term cumulative impact and trajectory patterns of childhood body mass index (BMI) with adult bone mass, and the mediation effect of adult BMI and body composition on these associations. A total of 397 Chinese adults (54.4%) who had been examined for BMI 4-8 times during childhood (6-19 years) and bone mass in adulthood (29-37 years), were included for analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.027DOI Listing
January 2019

Assessing bone impairment in ankylosing spondylitis (AS) using the trabecular bone score (TBS) and high-resolution peripheral quantitative computed tomography (HR-pQCT).

Bone 2019 Jan 29;122:8-13. Epub 2019 Jan 29.

Bone Metabolism Laboratory, Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address:

Objectives: To compare bone quality using the trabecular bone score (TBS) and bone microarchitecture in the distal tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT) in ankylosing spondylitis (AS) patients and healthy controls (HC).

Methods: Areal bone mineral density (aBMD) and TBS (TBS iNsight software) were evaluated using DXA (Hologic, QDR 4500); while volumetric bone mineral density (vBMD) and bone microarchitecture were analyzed in the distal tibia using HR-pQCT (Scanco) in 73 male patients with AS and 52 age-matched HC.

Results: AS patients were a mean 41. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.024DOI Listing
January 2019
2 Reads

Effects of disease-afflicted and aging neurons on the musculoskeletal system.

Authors:
Gregorio Valdez

Bone 2019 Jan 26;122:31-37. Epub 2019 Jan 26.

Fralin Biomedical Research Institute, Virginia Tech Carilion, Roanoke, VA, USA; Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA. Electronic address:

The musculoskeletal system includes skeletal muscles, bones and innervating axons from neurons in the central and peripheral nervous systems. Together, they form the largest structure in the body. They also initiate and coordinate locomotion, provide structural stability, and contribute to metabolism and homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.023DOI Listing
January 2019

Aortic aneurysm/dissection and osteogenesis imperfecta: Four new families and review of the literature.

Bone 2019 Jan 23;121:191-195. Epub 2019 Jan 23.

Center for Medical Genetics, University of Antwerp/Antwerp University Hospital, Antwerp, Belgium; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.

Osteogenesis imperfecta (OI) is the commonest form of heritable bone fragility. It is mainly characterized by fractures, hearing loss and dentinogenesis imperfecta. OI patients are at increased risk of cardiovascular disease of variable severity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.022DOI Listing
January 2019

Clinical and genetic analysis in a large Chinese cohort of patients with X-linked hypophosphatemia.

Bone 2019 Jan 23;121:212-220. Epub 2019 Jan 23.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Shuaifuyuan No. 1, Wangfujing, Dongcheng District, Beijing 100730, China. Electronic address:

X-linked Hypophosphatemia (XLH) is caused by loss of function mutations in the PHEX gene. Given the recent availability of a new therapy for XLH, a retrospective analysis of the most recent 261 Chinese patients with XLH evaluated at Peking Union Medical College Hospital was conducted. Clinical, biochemical, radiographic studies, as well as genetic analyses, including Sanger sequencing for point mutations and Multiplex Ligation-dependent Probe Amplification (MLPA) to detect large deletions/duplications were employed. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282193003
Publisher Site
http://dx.doi.org/10.1016/j.bone.2019.01.021DOI Listing
January 2019
4 Reads

Nutritional supplementation with myo-inositol in growing mice specifically augments mandibular endochondral growth.

Bone 2019 Jan 22;121:181-190. Epub 2019 Jan 22.

Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan.

Introduction: The purpose of this study was to examine growth-promoting effects of myo-inositol nutritional supplementation on the mandible in experimental animals.

Methods: Mice were fed on diets that contained various concentration of myo-inositol for 3 to 12 weeks. The length of the mandible, maxilla, and femur were measured on μCT images. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.020DOI Listing
January 2019

Fractures in school age children in relation to sex and ethnic background: The Generation R Study.

Bone 2019 Jan 22;121:227-231. Epub 2019 Jan 22.

Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Department of Internal Medicine, the Netherlands; Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, The Generation R Study, the Netherlands; Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Department of Epidemiology, the Netherlands. Electronic address:

Fracture rate in childhood is increasing and its consequences may affect health and developmental processes and cause school absence and restricted activity days. There are scarce epidemiologic studies regarding fractures in children. The aim of this study was to evaluate if pediatric fractures show disparities across sexes and ethnic groups. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282193002
Publisher Site
http://dx.doi.org/10.1016/j.bone.2019.01.019DOI Listing
January 2019
13 Reads

Lower baseline value and greater decline in BMD as independent risk factors for mortality in community dwelling elderly.

Bone 2019 Jan 17;121:204-211. Epub 2019 Jan 17.

Department of Internal Medicine, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Republic of Korea. Electronic address:

Skeleton plays diverse roles via crosstalk between others, thus it is conceivable that lower BMD per se may reflect negative influences on health status and threats to life independent of fracture events. We investigated investigate the association between BMD and mortality, and to examine whether the rate of bone loss can predict future mortality in an elderly population. This study was conducted as a part of the Korean Longitudinal Study on Health and Aging, a community-based prospective study of Korean people aged 65 years and older that began in 2005. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.017DOI Listing
January 2019
3 Reads

Absence of an osteopetrosis phenotype in IKBKG (NEMO) mutation-positive women: A case-control study.

Bone 2019 Jan 16;121:243-254. Epub 2019 Jan 16.

Department of Clinical Research, Faculty of Health, University of Southern Denmark (SDU), Winsløwparken 19. 3, DK-5000 Odense C, Denmark; Department of Clinical Genetics, Odense University Hospital, J.B. Winsløws Vej 4, DK-5000 Odense C, Denmark. Electronic address:

Background: NF-κB essential modulator (NEMO), encoded by IKBKG, is necessary for activation of the ubiquitous transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Animal studies suggest NEMO is required for NF-κB mediated bone homeostasis, but this has not been thoroughly studied in humans. IKBKG loss-of-function mutation causes incontinentia pigmenti (IP), a rare X-linked disease featuring linear hypopigmentation, alopecia, hypodontia, and immunodeficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.014DOI Listing
January 2019
4 Reads

Defective circadian control in mesenchymal cells reduces adult bone mass in mice by promoting osteoclast function.

Bone 2019 Jan 16;121:172-180. Epub 2019 Jan 16.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Serum bone turnover markers show diurnal variation in humans, suggesting that circadian rhythms contribute to normal bone physiology. This conclusion is corroborated by bone phenotypes in mice with genetic disruption of the circadian molecular clock mechanism, for instance via deletion of the transcription factor Brain and Muscle Arntl-like 1 (Bmal1). To dissect the contribution of circadian molecular clocks in individual bone cell types, we generated mice with conditional deletion of Bmal1 in osteoclasts (Ctsk-cre) and in mesenchymal cells of the limbs (Prx1-cre). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.016DOI Listing
January 2019
1 Read

Cellular senescence in bone.

Bone 2019 Jan 16;121:121-133. Epub 2019 Jan 16.

Division of Endocrinology and Metabolism and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Electronic address:

Cellular senescence refers to a process induced by various types of stress that causes irreversible cell cycle arrest and distinct cellular alterations, including profound changes in gene expression, metabolism, and chromatin organization as well as activation/reinforcement of anti-apoptotic pathways and development of a pro-inflammatory secretome or senescence-associated secretory phenotype (SASP). However, because of challenges and technical limitations in identifying and characterizing senescent cells in living organisms, only recently have some of the diverse in vivo roles of these unique cells been discovered. New findings indicate that senescent cells and their SASP can have acute beneficial functions, such as in tissue regeneration and wound healing. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282193001
Publisher Site
http://dx.doi.org/10.1016/j.bone.2019.01.015DOI Listing
January 2019
7 Reads

The relationship between volumetric thoracic bone mineral density and coronary calcification in men and women - results from the Copenhagen General Population Study.

Bone 2019 Jan 16;121:116-120. Epub 2019 Jan 16.

Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Radiology, The Diagnostic Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Background: The association between low bone mineral density (BMD) and the presence of coronary artery calcium (CAC) as a marker of atherosclerosis is unclear. The aim of this study was to assess the potential relationship between volumetric thoracic bone mineral density and coronary calcification in a large population of men and women.

Methods: Participants from the Copenhagen General Population Study underwent multidetector computed tomography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.010DOI Listing
January 2019
6 Reads

Characterising variability and regional correlations of microstructure and mechanical competence of human tibial trabecular bone: An in-vivo HR-pQCT study.

Bone 2019 Jan 15;121:139-148. Epub 2019 Jan 15.

Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Leicestershire, UK. Electronic address:

Objective: Quantifying spatial distribution of trabecular bone mechanical competence and microstructure is important for early diagnosis of skeletal disorders and potential risk of fracture. The objective of this study was to determine a spatial distribution of trabecular mechanical and morphological properties in human distal tibia and examine the contribution of regional variability of trabecular microarchitecture to mechanical competence.

Methods: A total of 340 representative volume elements at five anatomic regions of trabecular bone - anterior, posterior, lateral, medial and centre - from ten white European-origin postmenopausal women were studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.013DOI Listing
January 2019
2 Reads

Prevalent vertebral fracture on bone density lateral spine (VFA) images in routine clinical practice predict incident fractures.

Bone 2019 Jan 8;121:72-79. Epub 2019 Jan 8.

University of Manitoba, Winnipeg, Canada.

Purpose: The predictive validity of vertebral fracture assessment (VFA) on bone density lateral spine images to identify prevalent vertebral fractures in routine clinical practice has not been established. Our objective was to estimate the associations of prevalent vertebral fracture identified on VFA images in routine practice with incident hip, all non-vertebral, major osteoporotic, and clinical vertebral fractures, using the Manitoba Bone Density database.

Methods: From 2010 onward, 9972 men and women (mean age [SD] 76 [6. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282193000
Publisher Site
http://dx.doi.org/10.1016/j.bone.2019.01.009DOI Listing
January 2019
5 Reads

Adaptation of the proximal humerus to physical activity: A within-subject controlled study in baseball players.

Bone 2019 Jan 8;121:107-115. Epub 2019 Jan 8.

Department of Physical Therapy, School of Health and Human Sciences, Indiana University, Indianapolis, IN, United States of America.

The proximal humerus is a common, yet understudied site for osteoporotic fracture. The current study explored the impact of prolonged physical activity on proximal humerus bone health by comparing bone properties between the throwing and nonthrowing arms within professional baseball players. The proximal humerus in throwing arms had 28. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.008DOI Listing
January 2019
2 Reads

Weekly teriparatide treatment increases vertebral body strength by improving cortical shell architecture in ovariectomized cynomolgus monkeys.

Bone 2019 Jan 8;121:80-88. Epub 2019 Jan 8.

Department of Orthopedic Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

Weekly teriparatide treatment is reported to reduce the incidence of osteoporotic vertebral fractures. However, the effect of weekly teriparatide on cortical bone has not been clarified. This study aimed to examine the effects of weekly teriparatide treatment on bone mass, intracortical structure, and remodeling of the lumbar vertebral cortical shell and its relation to mechanical properties in ovariectomized cynomolgus monkeys. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282193000
Publisher Site
http://dx.doi.org/10.1016/j.bone.2019.01.006DOI Listing
January 2019
9 Reads

Hyperglycemic status is associated with an elevated risk of osteoporotic fracture in community-dwelling elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men (FORMEN) cohort study.

Bone 2019 Jan 5;121:100-106. Epub 2019 Jan 5.

Nara Medical University School of Medicine, 840 Shijocho, Kashihara, Nara 634-8521, Japan.

Purpose: Patients with type 2 diabetes mellitus have an increased fracture risk. However, population-based studies on the association between glycemic status and fracture risk are scarce, and none have targeted a Japanese population. In addition, patients in the lowest category of hemoglobin A1c (HbA1c) do not always show the lowest risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.005DOI Listing
January 2019
2 Reads

Outcomes following intravenous bisphosphonate infusion in pediatric patients: A 7-year retrospective chart review.

Bone 2019 Jan 4;121:60-67. Epub 2019 Jan 4.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.

Introduction: Intravenous bisphosphonates (IV BP) have been used to treat children with osteoporosis for many years. Favorable side effect profile and improvements in bone mineral density (BMD) have been demonstrated in patients with osteogenesis imperfecta (OI), a primary form of osteoporosis in pediatrics. Less is known about the safety of IV BP in children with secondary osteoporosis or glucocorticoid-induced osteoporosis (GIO). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.003DOI Listing
January 2019
2 Reads

Serum periostin levels and severity of fibrous dysplasia of bone.

Bone 2019 Jan 4;121:68-71. Epub 2019 Jan 4.

INSERM UMR 1033, Université de Lyon, Division of Rheumatology, Edouard Herriot University Hospital, 5 Place d'Arsonval, 69003 Lyon, France.

Fibrous dysplasia of bone (FD) is a rare congenital bone disease, characterized by a fibrous component in the bone marrow. Periostin has been extensively researched because of its implication in various fibrotic or inflammatory diseases. Periostin may be associated with the burden or the severity of FD. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S87563282193000
Publisher Site
http://dx.doi.org/10.1016/j.bone.2019.01.004DOI Listing
January 2019
6 Reads

3D patient-specific finite element models of the proximal femur based on DXA towards the classification of fracture and non-fracture cases.

Bone 2019 Jan 3;121:89-99. Epub 2019 Jan 3.

BCN MedTech, Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Osteoporotic bone fractures reduce quality of life and drastically increase mortality. Minimally irradiating imaging techniques such as dual-energy X-ray absorptiometry (DXA) allow assessment of bone loss through the use of bone mineral density (BMD) as descriptor. Yet, the accuracy of fracture risk predictions remains limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.001DOI Listing
January 2019
2 Reads

Constitutive activation of the alternative NF-κB pathway disturbs endochondral ossification.

Bone 2019 Jan 3;121:29-41. Epub 2019 Jan 3.

Division of Molecular Signaling and Biochemistry, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-kux, Kitakyushu 803-8580, Japan; Laboratory of Molecular and Cellular Biochemistry, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Oral Health/Brain Health/Total Health Research Center, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address:

Endochondral ossification is important for skeletal development. Recent findings indicate that the p65 (RelA) subunit, a main subunit of the classical nuclear factor-κB (NF-κB) pathway, plays essential roles in chondrocyte differentiation. Although several groups have reported that the alternative NF-κB pathway also regulates bone homeostasis, the role of the alternative NF-κB pathway in chondrocyte development is still unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.01.002DOI Listing
January 2019
6 Reads

Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis.

Bone 2019 Jan 2;121:16-28. Epub 2019 Jan 2.

Department of Orthopedics, Second Affiliated Hospital of Soochow University, 215004 Suzhou, China; Osteoporosis Institute, Soochow University, 215004 Suzhou, China. Electronic address:

Iron accumulation is an independent risk factor for type I osteoporosis, but the molecular mechanisms of the phenomenon are not well defined, and effective therapy has not been reported. Here, we found that the level of mTOR was increased both in wild-type mouse models with iron accumulation and transgenic mouse models (Hepc) of high-turnover osteoporosis with iron accumulation. We show that an increased level of mTOR can depress osteogenesis and angiogenesis by Cxcl9 both in bone and in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2018.12.019DOI Listing
January 2019
2 Reads

Effects of deprivation, ethnicity, gender and age on distal radius fracture incidence and surgical intervention rate.

Bone 2018 Dec 29;121:1-8. Epub 2018 Dec 29.

Academic Team of Musculoskeletal Surgery, University Hospitals of Leicester, Gwendolen Road, Leicester LE5 4PW, UK.

Introduction: Social deprivation has been shown to be associated with increased incidence of many types of fracture but the causes for this have not been established. The aim of this study was to establish if distal radius fracture was associated with deprivation and investigate reasons for this.

Method: Data was reviewed of 4463 adult patients who attended our Emergency Department over a four year period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2018.12.018DOI Listing
December 2018
1 Read

Novel fibronectin mutations and expansion of the phenotype in spondylometaphyseal dysplasia with "corner fractures".

Bone 2018 Dec 30;121:163-171. Epub 2018 Dec 30.

CHU Sainte Justine Research Centre and Department of Pediatrics, University of Montreal, Montreal, QC H3T 1C5, Canada. Electronic address:

Heterozygous pathogenic variants in the FN1 gene, encoding fibronectin (FN), have recently been shown to be associated with a skeletal disorder in some individuals affected by spondylometaphyseal dysplasia with "corner fractures" (SMD-CF). The most striking feature characterizing SMD-CF is irregularly shaped metaphyses giving the appearance of "corner fractures". An array of secondary features, including developmental coxa vara, ovoid vertebral bodies and severe scoliosis, may also be present. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2018.12.020DOI Listing
December 2018
1 Read

Bone adaptation compensates resorption when sciatic neurectomy is followed by low magnitude induced loading.

Bone 2019 Mar 23;120:487-494. Epub 2018 Dec 23.

Department of Bioengineering, Northeastern University, Boston, MA 02115, USA; Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA. Electronic address:

The uniaxial tibial loading model is commonly used to promote bone formation through mechanoadaptation in mice. Sciatic neurectomy on the other hand recruits osteoclasts, which results in bone loss. Previous studies have shown that combining sciatic neurectomy with high magnitude loading increases the amount of bone formed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2018.12.017DOI Listing
March 2019
1 Read