7,641 results match your criteria Bone[Journal]


The spatial differences in bone mineral density and hip structure between low-energy femoral neck and trochanteric fractures in elderly Chinese using quantitative computed tomography.

Bone 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Beijing Jishuitan Hospital, Beijing, China. Electronic address:

The purpose of this study was to investigate the differences in bone mineral density (BMD) and hip structure between femoral neck and trochanteric fractures in elderly Chinese individuals using quantitative computed tomography (QCT). A total of 625 Chinese patients (mean age 75.8 years) who sustained low-energy hip fractures (female: 293 femoral neck, 175 trochanteric; male: 82 femoral neck, 75 trochanteric) were recruited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193013
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http://dx.doi.org/10.1016/j.bone.2019.04.007DOI Listing
April 2019
1 Read

Influence of soft tissue on bone density and microarchitecture measurements by high-resolution peripheral quantitative computed tomography.

Bone 2019 Apr 15. Epub 2019 Apr 15.

Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, THR-1051 Boston, MA, USA; Harvard Medical School, 25 Shattuck St., Boston, MA, USA; Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, One Overland Street, Boston, MA, USA.

High-resolution peripheral quantitative computed tomography (HR-pQCT) is a non-invasive method of measuring volumetric bone mineral density (vBMD) and microarchitecture at the distal radius and tibia. With increasing use of this technology, it is crucial to understand the potential impact of overlying soft tissue on the accuracy of HR-pQCT measures. Thus, we examined the effects of a simulated increase in adiposity (via 6- and 12-mm thick layers of overlying circumferential fat) on HR-pQCT measures of a hydroxyapatite (HA) phantom and in women (n = 20, aged 18-75 years). Read More

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http://dx.doi.org/10.1016/j.bone.2019.04.008DOI Listing

Naproxen impairs load-induced bone formation, reduces bone toughness, and diminishes woven bone formation following stress fracture in mice.

Bone 2019 Apr 15;124:22-32. Epub 2019 Apr 15.

Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

Debilitating stress fractures are surprisingly common in physically active individuals, including athletes, military recruits, and dancers. These individuals are overrepresented in the 30 million daily users of non-steroidal anti-inflammatory drugs (NSAIDs). We hypothesized that regular use of NSAIDs would predispose habitually loaded bones to stress fracture and delay the repair of these injuries. Read More

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http://dx.doi.org/10.1016/j.bone.2019.04.009DOI Listing

IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2.

Bone 2019 Apr 11. Epub 2019 Apr 11.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu 807-8555, Japan. Electronic address:

Inflammation and vascular calcification are independent risk factors of cardiovascular events. Vascular smooth muscle cells (VSMCs) exhibit osteoblast-like characteristics in response to various stimuli such as oxidized cholesterol and inflammation. However the precise mechanism of transcriptional regulation of VSMCs by inflammatory stimuli remains unclear. Read More

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http://dx.doi.org/10.1016/j.bone.2019.04.006DOI Listing

The genetic architecture of osteoporosis and fracture risk.

Bone 2019 Apr 10. Epub 2019 Apr 10.

Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, Netherlands. Electronic address:

Osteoporosis and fracture risk are common complex diseases, caused by an interaction of numerous disease susceptibility genes and environmental factors. With the advances in genomic technologies, large-scale genome-wide association studies (GWAS) have been performed which have broadened our understanding of the genetic architecture and biological mechanisms of complex disease. Currently, more than ~90 loci have been found associated with DXA derived bone mineral density (BMD), over ~500 loci with heel estimated BMD and several others with other less widely available bone parameters such as bone geometry, shape, and microarchitecture. Read More

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http://dx.doi.org/10.1016/j.bone.2019.04.005DOI Listing
April 2019
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Use of oral bisphosphonates and risk of hospital admission with osteonecrosis of the jaw: Large prospective cohort study in UK women.

Bone 2019 Apr 5. Epub 2019 Apr 5.

Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK.

About 1 in 10 postmenopausal UK women are currently prescribed oral bisphosphonates, but there are concerns about their adverse effects. Osteonecrosis of the jaw is a recognised uncommon but important side effect of intravenous bisphosphonates, but epidemiological evidence on risk of osteonecrosis of the jaw associated with oral bisphosphonate use is less conclusive. The incidence of hospital admission with osteonecrosis of the jaw was examined among 521,695 Million Women Study participants, aged 64. Read More

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http://dx.doi.org/10.1016/j.bone.2019.04.003DOI Listing
April 2019
2 Reads

Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency.

Bone 2019 Apr 5;124:7-13. Epub 2019 Apr 5.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Electronic address:

In observational studies, vitamin D deficiency is a risk factor for low bone density and future fractures, whereas a causal relation has been difficult to show in randomized controlled trials (RCTs). Similarly, vitamin D deficiency has been associated with increased bone turnover, but RCTs with vitamin D have not shown conclusive effects. This could be due to inclusion of vitamin D sufficient subjects and low vitamin D doses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193013
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http://dx.doi.org/10.1016/j.bone.2019.04.002DOI Listing
April 2019
7 Reads

Changes in trabecular bone score and bone mineral density following allogeneic hematopoietic stem cell transplantation.

Bone 2019 Apr 6;124:40-46. Epub 2019 Apr 6.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea. Electronic address:

Purpose: It has been demonstrated that bone mineral density (BMD) loss is substantial within the first 12 months after allogeneic hematopoietic stem cell transplantation (alloHSCT). Declines in BMD showed a disproportionate cortical bone loss even though trabecular bone is metabolically more active than cortical bone. This finding suggests a unique mechanism. Read More

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http://dx.doi.org/10.1016/j.bone.2019.04.004DOI Listing
April 2019
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Corrigendum to "Effects of parathyroidectomy on the biology of bone tissue in patients with chronic kidney disease and secondary hyperparathyroidism" [Bone 121 (April 2019) 277-283].

Bone 2019 Apr 4;123:189-190. Epub 2019 Apr 4.

LIM 16 - Laboratorio de Fisiopatologia Renal, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Hospital Samaritano Americas Serviços Medicos, Sao Paulo, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2019.03.030DOI Listing
April 2019
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Proteomic studies of bone and skeletal health outcomes.

Bone 2019 Apr 4. Epub 2019 Apr 4.

Oregon Health & Science University, Portland, USA. Electronic address:

Proteins are an essential part of essentially all biological processes, and there is enormous variation in protein forms and concentrations that is not reflected in DNA or RNA. Recently there have been rapid advances in the ability to measure protein sequence, modification and concentration, particularly with methods based in mass spectrometry. Global measures of proteins in tissues or in the circulation provide a broad assessment of the proteome that can be extremely useful for discovery, and targeted proteomic measures can yield specific and sensitive assessments of specific peptides and proteins. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.032DOI Listing
April 2019
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Inverse correlation between trabecular bone volume and bone marrow adipose tissue in rats treated with osteoanabolic agents.

Bone 2019 Apr 4;123:211-223. Epub 2019 Apr 4.

Maine Medical Center Research Institute, Scarborough, ME, USA; University of Maine Graduate School of Biomedical Science and Engineering, Orono, ME, USA; Tufts University School of Medicine, Boston, MA, USA. Electronic address:

There is currently an unmet clinical need for improved treatments for skeletal diseases such as osteoporosis and cancer-induced bone disease. This is due in part to a paucity of novel targets and an incomplete understanding of the mechanisms of action for established therapies. We defined the effects of anabolic treatments on bone and the bone marrow adipocyte (BMA). Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.038DOI Listing
April 2019
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Vasculature submucosal changes at early stages of osteonecrosis of the jaw (ONJ).

Bone 2019 Apr 3;123:234-245. Epub 2019 Apr 3.

Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA 90095, USA. Electronic address:

Osteonecrosis of the jaw (ONJ), a rare, but potentially severe side effect of anti-resorptive medications, presents as exposed bone in the maxillofacial region lasting for at least 8 weeks. While clinical experience and animal models concur in finding that systemic antiresorptive treatment in conjunction with local risk factors, such as tooth extraction or dental disease may lead to ONJ development, the subclinical molecular changes that precede bone exposure remain poorly understood. The identification of these changes is not only important in understanding disease pathophysiology, but could provide potential for treatment development. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.031DOI Listing
April 2019
4 Reads

Incidence of hip fracture in Native American residents of U.S. nursing homes.

Bone 2019 Apr 3;123:204-210. Epub 2019 Apr 3.

Department of Health Services, Policy and Practice, School of Public Health, Brown University, 121 South Main Street, Providence, RI 02912, USA. Electronic address:

Objectives: To compare the standardized incidence rates (IRs) of hip fracture for Native Americans versus other racial groups in U.S. nursing homes (NHs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193012
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http://dx.doi.org/10.1016/j.bone.2019.04.001DOI Listing
April 2019
5 Reads

Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells.

Bone 2019 Apr 1. Epub 2019 Apr 1.

The Molecular Endocrinology & Stem Cell Research Unit (KMEB), Department of Endocrinology, Odense University Hospital & University of Southern Denmark, Odense, Denmark; Department of Cellular and Molecular Medicine, The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Panum Institute, University of Copenhagen, Copenhagen, Denmark; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address:

Aging is associated with decreased bone mass and accumulation of bone marrow adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived from a stem cell population within the bone marrow stroma called bone marrow stromal (skeletal or mesenchymal) stem cells (BMSC). In the present review, we provide an overview, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.041DOI Listing
April 2019
2 Reads

Type 1 diabetes onset at young age is associated with compromised bone quality.

Bone 2019 Mar 29;123:260-264. Epub 2019 Mar 29.

Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America.

Women with type 1 diabetes (T1D) are at increased risk for fracture. We studied the association of T1D and young age at T1D onset (T1D onset before 20 years) on bone structural quality. 24 postmenopausal women with T1D (mean age 60. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.039DOI Listing
March 2019
2 Reads

Aging of mouse intervertebral disc and association with back pain.

Bone 2019 Mar 29;123:246-259. Epub 2019 Mar 29.

Hospital for Special Surgery, New York, NY 10021, USA; Department of Cell and Developmental Biology, Weill Cornell Medicine, Graduate School of Medical Science, New York, NY 10065, USA. Electronic address:

With the increased burden of low back pain (LBP) in our globally aging population there is a need to develop preclinical models of LBP that capture clinically relevant features of physiological aging, degeneration, and disability. Here we assess the validity of using a mouse model system for age-related LBP by characterizing aging mice for features of intervertebral disc (IVD) degeneration, molecular markers of peripheral sensitization, and behavioral signs of pain. Compared to three-month-old and one-year-old mice, two-year-old mice show features typical of IVD degeneration including loss of disc height, bulging, innervation and vascularization in the caudal lumbar IVDs. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.037DOI Listing
March 2019
3 Reads

TRPV1 activation alters the function of Aδ and C fiber sensory neurons that innervate bone.

Bone 2019 Mar 29;123:168-175. Epub 2019 Mar 29.

Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia. Electronic address:

The Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a non-selective cation channel that is activated by capsaicin, low pH and noxious heat. It has been suggested to have a pro-algesic role in a range of conditions that present with bone pain, but the mechanisms by which this occurs are not yet clear. In this study we aimed to determine if TRPV1 is expressed in Aδ and/or C fiber bone afferent neurons, and to explore its role in the activation and/or sensitization of bone afferent neurons to mechanical stimulation. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.040DOI Listing

miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.

Bone 2019 Mar 28;123:129-136. Epub 2019 Mar 28.

Department of Orthopaedics, Yangpu District Central Hospital affiliated to Tongji University School of Medicine, Shanghai 200090, China.

MicroRNAs (miRNAs, miRs) are frequently dysregulated in osteoarthritis (OA), but the role of specific miRNAs in OA remains unclear. In this study, we found that miR-93-5p is underexpressed in human and rat OA-affected cartilage (compared with normal cartilage) as well as in IL-1β-treated chondrocytes. Overexpression of miR-93-5p promoted chondrocyte viability, suppressed chondrocyte apoptosis, and maintained the balance between anabolic and catabolic factors of the extracellular matrix in vitro. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.035DOI Listing

Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength.

Bone 2019 Mar 28;123:137-144. Epub 2019 Mar 28.

Divisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, United States of America. Electronic address:

Skeletal muscle weakness occurs with aging and in females this is compounded by the loss of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle strength from both inadequate preservation of skeletal muscle mass and decrements in the quality of the remaining skeletal muscle. Processes and components of skeletal muscle that are affected by estrogens are beginning to be identified. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.033DOI Listing

Role of hydrogen sulfide in the musculoskeletal system.

Bone 2019 Mar 27;124:33-39. Epub 2019 Mar 27.

Department of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA. Electronic address:

Hydrogen sulfide (HS) has been known as a gasotransmitter, and it contributes to various physiological and pathological processes. Multiple enzymes such as cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (MST) produce endogenous HS, and these are differentially expressed in the various tissue systems including the skeletal system. However, abnormal HS production is associated with deregulation of the signaling cascade and imbalanced tissue homeostasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193012
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http://dx.doi.org/10.1016/j.bone.2019.03.034DOI Listing
March 2019
5 Reads

Crosstalk between Activin A and Shh signaling contributes to the proliferation and differentiation of antler chondrocytes.

Bone 2019 Mar 27;123:176-188. Epub 2019 Mar 27.

College of Veterinary Medicine, Jilin University, Changchun, PR China. Electronic address:

Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signaling in the proliferation and differentiation of antler chondrocytes. We found that Activin A promoted chondrocyte proliferation and differentiation, and accelerated the transition of cell cycle from G1 into S phase along with the activation of Notch and Shh signaling whose blockage attenuated above function of Activin A. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.036DOI Listing

Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice.

Bone 2019 Mar 26;123:115-128. Epub 2019 Mar 26.

Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Box 951668 CHS B3-087, Los Angeles, CA 90095, USA. Electronic address:

Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw (MRONJ), is a morbid condition that represents a significant risk for oncology patients who have received high dose intravenous (IV) infusion of a potent nitrogen containing BP (N-BP) drug. At present, no clinical procedure is available to prevent or effectively treat MRONJ. Although the pathophysiological basis is not yet fully understood, legacy adsorbed N-BP in jawbone has been proposed to be associated with BRONJ by one or more mechanisms. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.027DOI Listing
March 2019
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Severe brachydactyly and short stature resulting from a novel pathogenic TRPS1 variant within the GATA DNA-binding domain.

Bone 2019 Mar 23;123:153-158. Epub 2019 Mar 23.

Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Brachydactyly type E, which can be an isolated finding or part of a syndrome in combination with other clinical anomalies, involves metacarpals and metatarsals with or without short phalanges. Herein we report two unrelated Turkish females who presented with brachydactyly type E and vitamin D deficiency in the absence of marked alterations in serum calcium, phosphate, and parathyroid hormone. After excluding disease-causing variants in two candidate genes, PTHLH and PDE4D, we identified different pathogenic variants in TRPS1, the gene mutated in patients with tricho-rhino-phalangeal syndrome (TRPS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193011
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http://dx.doi.org/10.1016/j.bone.2019.03.028DOI Listing
March 2019
3 Reads

Possible link between FSH and RANKL release from adipocytes in men with impaired gonadal function including Klinefelter syndrome.

Bone 2019 Mar 23;123:103-114. Epub 2019 Mar 23.

Group of skeletal, mineral and gonadal endocrinology, University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark; Division of Bone and Mineral Research, HSDM/HMS, Harvard Medical School, Boston, USA. Electronic address:

Introduction: The FSH receptor (FSHR) has been found to be expressed in human bone cells and bone marrow-adipocytes, and highly-debated mouse studies have suggested extra-gonadal effects of gonadotropins on glucose, adipocyte and bone homeostasis. These putative effects could be direct or indirectly mediated by endocrine factors released from bone-cells or adipocytes. Here, we investigated whether gonadotropins are linked with glucose- and lipid-metabolism in hypergonadotropic men. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.022DOI Listing

Phenotype and response to growth hormone therapy in siblings with B4GALT7 deficiency.

Bone 2019 Mar 23;124:14-21. Epub 2019 Mar 23.

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110, USA.

B4GALT7 encodes beta-1,4-galactosyltransferase which links glycosaminoglycans to proteoglycans in connective tissues. Rare, biallelic variants in B4GALT7 have been associated with spondylodysplastic Ehlers-Danlos and Larsen of Reunion Island syndromes. Thirty patients with B4GALT7-related disorders have been reported to date with phenotypic variability. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.029DOI Listing
March 2019
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Changes in Dkk-1, sclerostin, and RANKL serum levels following discontinuation of long-term denosumab treatment in postmenopausal women.

Bone 2019 Mar 22;123:191-195. Epub 2019 Mar 22.

Rheumatology Unit, University of Verona, Piazzale A. Scuro, 10, 37134 Verona, Italy.

Purpose: The positive effects of denosumab (DMAb) on bone mineral density (BMD) are quickly reversible after its discontinuation. We investigated whether this rebound was associated with dysregulation of the Wnt canonical pathway and/or by the increase in the receptor-activator of nuclear factor-kappa B ligand (RANKL) serum levels.

Methods: The study included patients (n = 15) with postmenopausal osteoporosis to whom DMAb was administered for 78 months and then discontinued. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.019DOI Listing

High frequency of paternal iso or heterodisomy at chromosome 20 associated with sporadic pseudohypoparathyroidism 1B.

Bone 2019 Mar 21;123:145-152. Epub 2019 Mar 21.

Normandie Univ, UNICAEN, CHU de Caen Normandie, Department of Genetics, Reference Center fo Rare Diseases of Calcium and Phosphorus Metabolism, EA7450 BioTARGen, 14000 Caen, France. Electronic address:

Pseudohypoparathyroidism 1B (PHP1B) is caused by maternal epigenetic defects in the imprinted GNAS cluster. PHP1B can follow an autosomal dominant mode of inheritance or occur sporadically (spor-PHP1B). These latter patients present broad methylation changes of two or more differentially methylated regions (DMR) that, when mimicking the paternal allele, raises the suspicious of the occurrence of paternal uniparental disomy of chromosome 20 (upd(20)pat). Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.023DOI Listing
March 2019
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Hyponatremia and metabolic bone disease in patients with epilepsy: A cross-sectional study.

Bone 2019 Mar 21;123:67-75. Epub 2019 Mar 21.

Department of Neurology, Rigshospitalet Glostrup, Valdemar Hansens vej 1-23, 2600 Glostrup, Denmark.

Aim: Patients with epilepsy frequently develop hyponatremia due to the treatment with antiepileptic drugs and have an increased risk of developing metabolic bone disease. Hyponatremia is known to be associated with osteoporosis. The aim of the study was to investigate the association between hyponatremia and osteoporosis in patients with epilepsy. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.017DOI Listing
March 2019
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Deletion of FOXO1 in chondrocytes rescues the effect of diabetes on mechanical strength in fracture healing.

Bone 2019 Mar 21;123:159-167. Epub 2019 Mar 21.

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Diabetes increases the risk of fracture, impairs fracture healing and causes rapid loss of the fracture callus cartilage, which was linked to increased FOXO1 expression in chondrocytes. We recently demonstrated that deletion of FOXO1 in chondrocytes blocked the premature removal of cartilage associated with endochondral bone formation during fracture healing. However, the ultimate impact of this deletion on mechanical strength was not investigated and remains unknown. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.026DOI Listing

Targeting vascular endothelial growth factor ameliorates PMMA-particles induced inflammatory osteolysis in murine calvaria.

Bone 2019 Mar 21;123:86-91. Epub 2019 Mar 21.

Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, United States of America. Electronic address:

Cytokines and growth factors mediate inflammatory osteolysis in response to particles released from bone implants. However, the mechanism by which this process develops is not entirely clear. Blood vessels and related factors may be required to deliver immune cells and soluble factors to the injury site. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.025DOI Listing

Vibration enhances osteoclastogenesis by inducing RANKL expression via NF-κB signaling in osteocytes.

Bone 2019 Mar 20;123:56-66. Epub 2019 Mar 20.

Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan; Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, Hokkaido 060-8586, Japan. Electronic address:

To shorten the duration of orthodontic treatment it is important not only to reduce risks such as dental caries, periodontal disease, and root resorption, but also to decrease pain and discomfort caused by a fixed appliance. Several studies have investigated the effect of vibration applied to fixed appliances to accelerate tooth movement. Although it was reported that vibration accelerates orthodontic tooth movement by enhancing alveolar bone resorption, the underlying cellular and molecular mechanisms remain unclear. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.024DOI Listing

Calcium and vitamin D supplementation and bone health in Marine recruits: Effect of season.

Bone 2019 Mar 20;123:224-233. Epub 2019 Mar 20.

Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, United States of America.

Stress fractures are common overuse injuries caused by repetitive bone loading. These fractures are of particular concern for military recruits and athletes resulting in attrition in up to 60% of recruits that sustain a fracture. Army and Navy recruits supplemented with daily calcium and vitamin D (Ca + D) demonstrated improved bone strength and reduced stress fractures. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.021DOI Listing
March 2019
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MicroRNA-181a/b-1 over-expression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolism.

Bone 2019 Mar 19;123:92-102. Epub 2019 Mar 19.

Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, United States of America; Department of Cell Biology, Washington University School of Medicine, St. Louis, MO, United States of America; Shriners Hospital for Children - St Louis, St Louis, MO, United States of America. Electronic address:

MicroRNAs are small non-coding RNAs that play important roles in many cellular processes including proliferation, metabolism and differentiation. They function by binding to specific regions within the 3'UTR of target mRNAs resulting in suppression of protein synthesis and modulation of potentially many cellular pathways. We previously showed that miRNA expression levels differed between cells from distinct regions of developing human embryonic long bones. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.020DOI Listing
March 2019
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The contribution of the pericanalicular matrix to mineral content in human osteonal bone.

Bone 2019 Mar 18;123:76-85. Epub 2019 Mar 18.

Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14476 Potsdam, Germany.

The osteocyte lacunar-canalicular network (LCN) penetrates bone and houses the osteocytes and their processes. Despite its rather low volume fraction, the LCN represents an outstanding large surface that is possibly used by the osteocytes to interact with the surrounding mineralized bone matrix thereby contributing to mineral homeostasis. The aim of this study was to quantitatively describe such contributions by spatially correlating the local density of the LCN with the mineral content at the same location in micrometer-sized volume elements in human osteons. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.018DOI Listing
March 2019
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Silencing GSK3β instead of DKK1 can inhibit osteogenic differentiation caused by co-exposure to fluoride and arsenic.

Bone 2019 Mar 16;123:196-203. Epub 2019 Mar 16.

Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.

Chronic exposure to combined fluoride (F) and arsenic (As) continues to be a major public health problem worldwide, attracting the attention of an increasing number of researchers. While bone is the main target organ of syndrome of endemic arsenic poisoning and fluorosis (SEAF), the specific mechanism and targeted intervention remains uncertain. The first question in this study sought to determine the interaction of F and As on the Wnt signaling pathway and its role in osteogenic differentiation in the SEAF population. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.016DOI Listing
March 2019
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Functional characterization of the C7ORF76 genomic region, a prominent GWAS signal for osteoporosis in 7q21.3.

Bone 2019 Mar 14;123:39-47. Epub 2019 Mar 14.

Department of Genetics, Microbiology and Statistics, Facultat de Biologia, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, IBUB, IRSJD, Barcelona, Catalonia, Spain. Electronic address:

Genome-wide association studies (GWAS) have repeatedly identified genetic variants associated with bone mineral density (BMD) and osteoporotic fracture in non-coding regions of C7ORF76, a poorly studied gene of unknown function. The aim of the present study was to elucidate the causality and molecular mechanisms underlying the association. We re-sequenced the genomic region in two extreme BMD groups from the BARCOS cohort of postmenopausal women to search for functionally relevant variants. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.014DOI Listing
March 2019
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The association between bone mineral density gene variants and osteocalcin at baseline, and in response to exercise: The Gene SMART study.

Bone 2019 Mar 14;123:23-27. Epub 2019 Mar 14.

Institute for Health and Sport (iHeS), Victoria University, Melbourne, Australia.; Murdoch Childrens Research Institute, Melbourne, Australia. Electronic address:

Introduction: Osteocalcin (OC) is used as a surrogate marker for bone turnover in clinical settings. As bone mineral density (BMD) is largely heritable, we tested the hypothesis that a) bone-associated genetic variants previously identified in Genome-Wide Association Studies (GWAS) and combined into a genetic risk score (GRS) are associated with a) circulating levels of OC and b) the changes in OC following acute exercise.

Methods: Total OC (tOC), undercarboxylated OC (ucOC), and carboxylated OC (cOC) were measured in serum of 73 healthy Caucasian males at baseline and after a single bout of high-intensity interval exercise. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.015DOI Listing
March 2019
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KBG syndrome presenting with brachydactyly type E.

Bone 2019 Mar 12;123:18-22. Epub 2019 Mar 12.

Bone Division, Garvan Institute of Medical Research, Sydney, Australia; Department of Endocrinology, St Vincent's Hospital Sydney, Australia; School of Medicine, UNSW, Sydney, Australia; School of Medicine Sydney, University of Notre Dame, Australia.

We report the case of a young woman who presented at age 10 years with height on the tenth centile, brachydactyly type E and mild developmental delay. Biochemistry and hormonal profiles were normal. Differential diagnoses considered included Albright hereditary osteodystrophy without hormone resistance (a. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.012DOI Listing
March 2019
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Ultrashort echo time magnetic resonance imaging (UTE-MRI) of cortical bone correlates well with histomorphometric assessment of bone microstructure.

Bone 2019 Mar 12;123:8-17. Epub 2019 Mar 12.

Radiology Service, VA San Diego Healthcare System, San Diego, CA, USA; Department of Radiology, University of California, San Diego, CA, USA. Electronic address:

Ultrashort echo time magnetic resonance imaging (UTE-MRI) techniques have been increasingly used to assess cortical bone microstructure. High resolution micro computed tomography (μCT) is routinely employed for validating the MRI-based assessments. However, water protons in cortical bone may reside in micropores smaller than the detectable size ranges by μCT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193008
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http://dx.doi.org/10.1016/j.bone.2019.03.013DOI Listing
March 2019
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Microcracks in subchondral bone plate is linked to less cartilage damage.

Bone 2019 Mar 9;123:1-7. Epub 2019 Mar 9.

Inserm UMR1132 and Paris Diderot University, Paris, France. Electronic address:

Objectives: Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartilage and subchondral bone plate in relation to cartilage damage in humans and to better define the association of microcracks and osteocyte density in subchondral bone. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.011DOI Listing

Evolution of heterotopic bone in fibrodysplasia ossificans progressiva: An [F]NaF PET/CT study.

Bone 2019 Mar 8;124:1-6. Epub 2019 Mar 8.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Internal Medicine Section Endocrinology, Amsterdam Bone Center, Amsterdam Movement Sciences, the Netherlands. Electronic address:

Fibrodysplasia ossificans progressiva (FOP) is a rare, autosomal dominant disorder characterized by heterotopic ossification (HO) in muscles, ligaments and tendons. Flare-ups often precede the formation of HO, resulting in immobilization of joints. Due to progression of the disease without signs of a flare-up, co-existence of a chronic progression of HO has been postulated, but conclusive evidence is lacking. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.009DOI Listing
March 2019
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Seasonal variation of serum 25-hydroxyvitamin D and parameters of bone and mineral disorder in dialysis patients.

Bone 2019 Mar 8. Epub 2019 Mar 8.

Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine, Orange, CA, USA; Long Beach Veterans Affairs Healthcare System, Long Beach, CA, USA. Electronic address:

Background: Vitamin D deficiency is common among dialysis patients and may impact blood concentrations of calcium, phosphorus, intact parathyroid hormone (iPTH), and alkaline phosphatase (ALP). Seasonal variation of serum 25-hydroxyvitamin D [25(OH)D] concentrations has been well established for the general population; however, less is known about circannual variation in 25(OH)D as well as other parameters of mineral and bone disorder among dialysis patients.

Method: Based on 57,500 serum 25(OH)D measurements collected over two years from January 2009 to December 2010 among 25,025 dialysis patients, we evaluated the circannual variations in serum concentrations of 25(OH)D, calcium, phosphorus, iPTH, and ALP by a linear regression model with a cosinor function for the time period (month). Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.003DOI Listing
March 2019
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Oral dosing of pentoxifylline, a pan-phosphodiesterase inhibitor restores bone mass and quality in osteopenic rabbits by an osteogenic mechanism: A comparative study with human parathyroid hormone.

Bone 2019 Mar 9;123:28-38. Epub 2019 Mar 9.

Division of Endocrinology, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow 226031, India. Electronic address:

The non-selective phosphodiesterase inhibitor pentoxifylline (PTX) is used for the treatment of intermittent claudication due to artery occlusion. Previous studies in rodents have reported salutary effects of the intraperitoneal administration of PTX in segmental bone defect and fracture healing, as well as stimulation of bone formation. We determined the effect of orally dosed PTX in skeletally mature ovariectomized (OVX) rabbits with osteopenia. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.010DOI Listing
March 2019
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GIT1 is critical for formation of the CD31Emcn vessel subtype in coupling osteogenesis with angiogenesis via modulating preosteoclasts secretion of PDGF-BB.

Bone 2019 May 7;122:218-230. Epub 2019 Mar 7.

Department of Orthopedic, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd., Nanjing 210029, China. Electronic address:

G protein-coupled receptor kinase 2 interacting protein-1 (GIT1) is a scaffold protein that plays a vital role in bone modeling and remodeling during osteogenesis coupled with angiogenesis. Recent studies have shown that a specialized subset of vascular endothelium strongly positive for CD31 and Endomucin (CD31Emcn) is coupled with anabolic bone formation. Based on our previous finding that GIT1 knockout (GIT1 KO) mice have impaired angiogenesis and bone formation, we hypothesized that GIT1 affects formation of the CD31Emcn vessel subtype. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193008
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http://dx.doi.org/10.1016/j.bone.2019.03.006DOI Listing
May 2019
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Discovery and validation an eight-biomarker serum gene signature for the diagnosis of steroid-induced osteonecrosis of the femoral head.

Bone 2019 May 8;122:199-208. Epub 2019 Mar 8.

Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China. Electronic address:

Steroid-induced osteonecrosis of the femoral head (SONFH) is difficult to be diagnosed at the early stages when it can be administrated effectively. Yet, to date no study has been performed to identify diagnostic biomarkers and to develop diagnostic models for SONFH. In the current study, a total of 60 SONFH patients with Association Research Circulation Osseous (ARCO) stages I-IV, and 20 controls were enrolled and divided into the discovery and validation cohorts. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.008DOI Listing
May 2019
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Suboptimal bone microarchitecure in adolescent girls with obesity compared to normal-weight controls and girls with anorexia nervosa.

Bone 2019 May 7;122:246-253. Epub 2019 Mar 7.

Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, United States of America; Division of Pediatric Endocrinology, Massachusetts General Hospital for Children, Harvard Medical School, United States of America.

Background: Despite their higher areal bone mineral density (aBMD), adolescents with obesity (OB) have an increase in fracture risk, particularly of the extremities, compared with normal-weight controls. Whereas bone parameters that increase fracture risk are well characterized in anorexia nervosa (AN), the other end of nutritional spectrum, these data are lacking in adolescents with obesity.

Objective: Our objective was to compare bone parameters in adolescent girls across the nutritional spectrum, to determine whether suboptimal bone adaptation to increased body weight may explain the increased fracture risk in OB. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.007DOI Listing
May 2019
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Influence of bone lesion location on femoral bone strength assessed by MRI-based finite-element modeling.

Bone 2019 May 7;122:209-217. Epub 2019 Mar 7.

New York University, New York, NY, United States of America.

Currently, clinical determination of pathologic fracture risk in the hip is conducted using measures of defect size and shape in the stance loading condition. However, these measures often do not consider how changing lesion locations or how various loading conditions impact bone strength. The goal of this study was to determine the impact of defect location on bone strength parameters in both the sideways fall and stance-loading conditions. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.005DOI Listing
May 2019
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Whole-exome sequencing in a Japanese pedigree implicates a rare non-synonymous single-nucleotide variant in BEST3 as a candidate for mandibular prognathism.

Bone 2019 May 5;122:193-198. Epub 2019 Mar 5.

Department of Orthodontics, Division of Oral Functional Science, Graduate School of Dental Medicine, Hokkaido University, Kita 13 Nishi 7, Kita-ku, Sapporo 060-8586, Japan.

Mandibular prognathism is a phenotype of facial deformity seen in populations around the world, but with higher incidence among East Asian populations. Five genome-wide nonparametric linkage analyses and a genome-wide association study to identify susceptibility loci of the phenotype have shown inconsistent results. To explore variants related to mandibular prognathism, we undertook whole-exome sequencing in a Japanese pedigree. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.004DOI Listing

Murine models of accelerated aging and musculoskeletal disease.

Bone 2019 Mar 4. Epub 2019 Mar 4.

Institute on the Biology of Aging and Metabolism, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, United States of America; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, United States of America. Electronic address:

The primary risk factor for most musculoskeletal diseases, including osteoarthritis, osteoporosis and sarcopenia, is aging. To treat the diverse types of musculoskeletal diseases and pathologies, targeting their root cause, the aging process itself, has the potential to slow or prevent multiple age-related musculoskeletal conditions simultaneously. However, the development of approaches to delay onset of age related diseases, including musculoskeletal pathologies, has been slowed by the relatively long lifespan of rodent models of aging. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.002DOI Listing
March 2019
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Longitudinal changes in hip geometry in relation to the final menstrual period: Study of Women's Health Across the Nation (SWAN).

Bone 2019 May 3;122:237-245. Epub 2019 Mar 3.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Background: In SWAN, we showed that accelerated loss of bone mineral density (BMD) begins 1 year before the final menstrual period (FMP) to 2 years after the FMP and slows thereafter. However, the risk of fracture depends on both BMD and bone geometry. The hip structural analysis (HSA) measures important geometric properties of bone. Read More

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http://dx.doi.org/10.1016/j.bone.2019.02.016DOI Listing
May 2019
1 Read