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Bois Et Forets Des Tropiques[Journal] Publications | PubFacts

3,955 results match your criteria Bois Et Forets Des Tropiques[Journal]


Grapevine virus M, a novel vitivirus discovered in the American hybrid bunch grape cultivar Blanc du Bois in Texas.

Arch Virol 2019 Apr 15. Epub 2019 Apr 15.

Department of Horticultural Sciences, Texas A&M University, College Station, TX, 77843, USA.

A novel ssRNA (+) virus with molecular properties typical of members of the genus Vitivirus (family Betaflexiviridae; subfamily Trivirinae) was discovered by high-throughput sequencing in samples of the American hybrid bunch grape cultivar Blanc du Bois in Texas. The results were independently confirmed by Sanger sequencing of the virus isolate, whose genome length is 7,387 nt, excluding the polyA tail. The genome sequence contains five ORFs that are homologous and phylogenetically related to ORFs of grapevine-infecting vitiviruses. Read More

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http://link.springer.com/10.1007/s00705-019-04252-7
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http://dx.doi.org/10.1007/s00705-019-04252-7DOI Listing
April 2019
1 Read

Mobilization of Microbiota Commensals and Their Bacteriocins for Therapeutics.

Trends Microbiol 2019 Apr 12. Epub 2019 Apr 12.

Biochemistry and Genetics of Microorganisms (BGM), Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, 1348 Louvain-la-Neuve, Belgium; Syngulon, rue du Bois Saint-Jean 15/1, 4102, Seraing, Belgium. Electronic address:

With the specter of resurgence of pathogens due to the propagation of antibiotic-resistance genes, innovative antimicrobial strategies are needed. In this review, we summarize the beneficial aspects of bacteriocins, a set of miscellaneous peptide-based bacterium killers, compared with classical antibiotics, and emphasize their use in cocktails to curb the emergence of new resistance. We highlight that their prey spectrum, their molecular malleability, and their multiple modes of production might lead to specific and personalized treatments to prevent systemic disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0966842X193007
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http://dx.doi.org/10.1016/j.tim.2019.03.007DOI Listing
April 2019
1 Read

Development of a defined approach for eye irritation or serious eye damage for neat liquids based on cosmetics Europe analysis of in vitro RhCE and BCOP test methods.

Toxicol In Vitro 2019 Apr 11. Epub 2019 Apr 11.

The Procter & Gamble Company, Egham, United Kingdom.

The focus of Cosmetics Europe's ocular toxicity programme is on development of testing strategies and defined approaches for identification of ocular effects of chemicals in the context of OECD's Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation. Cosmetics Europe created a comprehensive database of chemicals for which in vitro data are available with corresponding historical in vivo Draize eye data and physicochemical properties. This database allowed further exploration of the initially proposed strategies from the CON4EI project and to identify opportunities for refinement. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.04.011DOI Listing
April 2019
1 Read

Deleterious somatic variants in 473 consecutive individuals with ovarian cancer: results of the observational AGO-TR1 study (NCT02222883).

J Med Genet 2019 Apr 12. Epub 2019 Apr 12.

Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte Evangelische Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany.

Background: For individuals with ovarian cancer (OC), therapy options mainly depend on germline status. What is the prevalence of deleterious somatic variants, that is, does genetic tumour testing identify subgroups of individuals who also might benefit from targeted therapy?

Methods: Paired analysis of tumour-derived versus blood-derived DNA to determine the prevalence of deleterious somatic variants in OC predisposition genes (, , , , and ) and the and genes in individuals with OC (AGO-TR1 study, NCT02222883). Results were complemented by , and promoter methylation analyses and stratified by histological subtype; 473 individuals were included. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105930DOI Listing

Darwin and Neuroscience: The German Connection.

Front Neuroanat 2019 26;13:33. Epub 2019 Mar 26.

Department of History, University of Colorado Denver, Denver, CO, United States.

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http://dx.doi.org/10.3389/fnana.2019.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443820PMC

HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion.

Mol Genet Genomic Med 2019 Apr 9:e602. Epub 2019 Apr 9.

Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty, Max-Delbrueck-Center for Molecular Medicine (MDC), Berlin, Germany.

Background: Studying patients with rare Mendelian diabetes has uncovered molecular mechanisms regulating β-cell pathophysiology. Previous studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic endocrine cell function and glucose homeostasis.

Methods: We performed exome sequencing in one adolescent nonautoimmune diabetic patient and detected one de novo predicted disease-causing HDAC4 variant (p. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.602
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http://dx.doi.org/10.1002/mgg3.602DOI Listing
April 2019
3 Reads

Acetyl Groups in : Fate of Acetates during Organosolv and Ionosolv Pulping.

Polymers (Basel) 2018 Jun 5;10(6). Epub 2018 Jun 5.

Chair of Forest Biomaterials, University of Freiburg, Werthmannstr. 6, 79085 Freiburg im Breisgau, Germany.

During biomass fractionation, any native acetylation of lignin and heteropolysaccharide may affect the process and the resulting lignin structure. In this study, (TC) and its lignin isolated by milling (MWL), ionosolv (ILL) and organosolv (EOL) methods were investigated for acetyl group content using FT-Raman, ¹H NMR, 2D-NMR, back-titration, and Zemplén transesterification analytical methods. The study revealed that TC is a highly acetylated grass; extractive free TC (TC) and TC MWL exhibited similar values of acetyl content: 6 wt % and 8 wt % by Zemplén transesterification, respectively, and 11 wt % by back-titration. Read More

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http://dx.doi.org/10.3390/polym10060619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404047PMC

Combining conventional therapy with immunotherapy: A risky business?

Eur J Cancer 2019 Apr 6;113:41-44. Epub 2019 Apr 6.

Department of Gynaecology and Obstetrics, Leuven Cancer Institute, UZ Leuven, Leuven, Belgium; Department of Oncology, Laboratory of Tumour Immunology and Immunotherapy, ImmunOvar Research Group, KU Leuven, Leuven, Belgium; Department of Oncology, Laboratory of Gynecologic Oncology, KU Leuven, Leuven, Belgium. Electronic address:

Because of the failure of immunotherapy as single agent in a number of cancers, current clinical trials are focusing on combining immunotherapy with other therapies. The most frequently chosen combination for immunotherapy is chemotherapy. However, almost no preclinical data on this combination is available. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.02.014DOI Listing

First comparison of performances between the new whole-body cadmium-zinc-telluride SPECT-CT camera and a dedicated cardiac CZT camera for myocardial perfusion imaging: Analysis of phantom and patients.

J Nucl Cardiol 2019 Apr 8. Epub 2019 Apr 8.

Nuclear Medicine Department, IRIS, Hôpital Privé Le Bois, Lille, France.

Background: Dedicated cardiac Cadmium-zinc-telluride (CZT) cameras show superior performances compared with Anger systems, particularly in terms of spatial resolution and count sensitivity. This study evaluated the performances of a new polyvalent whole body CZT camera (DNM 670CZT) compared with a cardiac dedicated CZT camera (DNM 530c) for myocardial perfusion SPECT.

Methods: The spatial resolution was evaluated with three linear sources filled with Tc. Read More

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http://link.springer.com/10.1007/s12350-019-01702-2
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http://dx.doi.org/10.1007/s12350-019-01702-2DOI Listing
April 2019
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α,ω-Epoxide, Oxetane, and Dithiocarbonate Telechelic Copolyolefins: Access by Ring-Opening Metathesis/Cross-Metathesis Polymerization (ROMP/CM) of Cycloolefins in the Presence of Functional Symmetric Chain-Transfer Agents.

Polymers (Basel) 2018 Nov 9;10(11). Epub 2018 Nov 9.

Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes)-UMR 6226, F-35000 Rennes, France.

Epoxide- and oxetane-α,ω-telechelic (co)polyolefins have been successfully synthesized by the tandem ring-opening metathesis polymerization (ROMP)/cross-metathesis (CM) of cyclic olefins using Grubbs' second-generation catalyst () in the presence of a bifunctional symmetric alkene epoxide- or oxetane-functionalized chain-transfer agent (CTA). From cyclooctene (COE), ,,-1,5,9-cyclododecatriene (CDT), norbornene (NB), and methyl 5-norbornene-2-carboxylate (NB), with bis(oxiran-2-ylmethyl) maleate (CTA ), bis(oxetane-2-ylmethyl) maleate (CTA ), or bis(oxetane-2-ylmethyl) ()-hex-3-enedioate (CTA ), well-defined α,ω-di(epoxide or oxetane) telechelic PCOEs, P(COE--NB or -NB)s, and P(NB--CDT)s were isolated under mild operating conditions (40 or 60 °C, 24 h). The oxetane CTA and the epoxide CTA were revealed to be significantly more efficient in the CM step than CTA , which apparently inhibits the reaction. Read More

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http://dx.doi.org/10.3390/polym10111241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401821PMC
November 2018

Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos.

Int J Mol Sci 2019 Apr 6;20(7). Epub 2019 Apr 6.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-box 824, 3000 Leuven, Belgium.

Zebrafish-based platforms have recently emerged as a useful tool for toxicity testing as they combine the advantages of in vitro and in vivo methodologies. Nevertheless, the capacity to metabolically convert xenobiotics by zebrafish eleuthero embryos is supposedly low. To circumvent this concern, a comprehensive methodology was developed wherein test compounds (i. Read More

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https://www.mdpi.com/1422-0067/20/7/1712
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http://dx.doi.org/10.3390/ijms20071712DOI Listing
April 2019
2 Reads
2.862 Impact Factor

A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity.

Toxicol In Vitro 2019 Apr 4;59:44-50. Epub 2019 Apr 4.

Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as due to scientific reasons calling for more human-based strategies. A critical aspect of this challenge is linked to the capacity to cover a comprehensive set of interdependent mechanisms of action, link them to adverse effects and interpret their probability to be triggered in the light of the exposure at the (sub)cellular level. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.04.005DOI Listing

Crystallinity dependency of the time-dependent mechanical response of polyethylene: application in total disc replacement.

J Mater Sci Mater Med 2019 Apr 5;30(4):46. Epub 2019 Apr 5.

Ramsay Générale de Santé, Hôpital privé Le Bois, 59000, Lille, France.

Degeneration of the intervertebral disc (IVD) is a leading source of chronic low back pain or neck pain, and represents the main cause of long-term disability worldwide. In the aim to relieve pain, total disc replacement (TDR) is a valuable surgical treatment option, but the expected benefit strongly depends on the prosthesis itself. The present contribution is focused on the synthetic mimic of the native IVD in the aim to optimally restore its functional anatomy and biomechanics, and especially its time-dependency. Read More

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http://dx.doi.org/10.1007/s10856-019-6243-9DOI Listing

Population pharmacokinetic reanalysis of a Diazepam PBPK model: a comparison of Stan and GNU MCSim.

J Pharmacokinet Pharmacodyn 2019 Apr 4. Epub 2019 Apr 4.

School of Chemical Engineering, National Technical University of Athens, 9 Heroon Polytechneiou Street, Zografou Campus, 15780, Athens, Greece.

The aim of this study is to benchmark two Bayesian software tools, namely Stan and GNU MCSim, that use different Markov chain Monte Carlo (MCMC) methods for the estimation of physiologically based pharmacokinetic (PBPK) model parameters. The software tools were applied and compared on the problem of updating the parameters of a Diazepam PBPK model, using time-concentration human data. Both tools produced very good fits at the individual and population levels, despite the fact that GNU MCSim is not able to consider multivariate distributions. Read More

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http://dx.doi.org/10.1007/s10928-019-09630-xDOI Listing

Screening strategy for Chagas disease in a non-endemic country (Switzerland): a prospective evaluation.

Swiss Med Wkly 2019 Mar 4;149:w20050. Epub 2019 Apr 4.

Department of Ambulatory Care and Community Medicine, University Hospital of Lausanne, Switzerland / Swiss Tropical and Public Health Institute, University of Basel, Switzerland.

The WHO recommends screening of Latin American migrants for Chagas disease to reduce morbidity and mortality and increase the likelihood of eradicating the disease. The objective was to assess the feasibility and acceptability of a screening strategy in one Swiss canton. From February 2011 to September 2012, people attending six healthcare centres of different types were offered a rapid diagnostic test if they or their mother were of Latin American origin (or, at the blood donation centre, if they had travelled for ≥1 year in Latin America). Read More

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http://dx.doi.org/10.4414/smw.2019.20050DOI Listing

Updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland.

Swiss Med Wkly 2019 Mar 3;149:w20031. Epub 2019 Apr 3.

Oncology Centre Hirslanden and Zurich, Switzerland.

This update on plasma cell myeloma has been elaborated by a Swiss expert panel as a result of the plethora of new data on the treatment of plasma cell myeloma reported recently. It adds new insights to the more extensive review that was published 3 years ago and may help clinicians on decision making for their patients. The new recommendations for distinguishing plasma cell myeloma from smouldering myeloma are briefly presented, including a section on contemporary imaging studies with this respect. Read More

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https://doi.emh.ch/smw.2019.20031
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http://dx.doi.org/10.4414/smw.2019.20031DOI Listing
March 2019
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Early Modeled Longitudinal CA-125 Kinetics and Survival of Ovarian Cancer Patients: A GINECO AGO MRC CTU Study.

Clin Cancer Res 2019 Apr 1. Epub 2019 Apr 1.

Medical oncoloy, CITOHL, Institut de Cancérologie des Hospices Civils de Lyon

Background: Regarding CA-125 longitudinal kinetics during chemotherapy, the actual predictive value of the Gynecology Cancer InterGroup (GCIG) CA-125 response criterion is questioned. The modeled CA-125 elimination rate constant KELIM exhibited higher prognostic value in recurrent ovarian cancer patients enrolled in CALYPSO trial. The objective was to validate the higher predictive & prognostic values of KELIM during first line treatments. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3335DOI Listing

Online training on how to diagnose anoperineal lesions of Crohn's disease: Do pictures matter? A nationwide randomized study.

Clin Res Hepatol Gastroenterol 2019 Mar 29. Epub 2019 Mar 29.

Philippe-Marteau, université Paris Sorbonne, AP-HP, pole digestif, hôpital Saint Antoine 75012 Paris, France. Electronic address:

Any gastroenterologist must be trained to properly diagnose anoperineal lesions in patients with Crohn's disease (APLOC). The aim of this study was to establish whether adding pictures would improve teaching effectiveness of the diagnosis of APLOC to French gastroenterology trainees.

Method: Trainees were asked to answer a first web-based survey consisting of evaluating 12 pictures of APLOC with a closed answer questionnaire. Read More

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http://dx.doi.org/10.1016/j.clinre.2018.12.003DOI Listing
March 2019
1 Read

[Potential value of placental angiogenic factors as biomarkers in preeclampsia for clinical physicians].

Nephrol Ther 2019 Mar 29. Epub 2019 Mar 29.

Service de néphrologie et de dialyse de l'hôpital Américain de Paris, 63, boulevard Victor Hugo, 92200 Neuilly-sur-Seine, France; Service de néphrologie et de dialyse, hôpital Bichat, 46, rue Henri Huchard, 75018 Paris, France.

The role of angiogenic factors in the onset of clinical manifestations of preeclampsia was demonstrated in 2003 by the implication of sFlt-1, PlGF and VEGF, and in 2006 by the implication of soluble endoglin. Placental ischemia and inflammation observed in preeclampsia alter both the production and progression of angiogenic factors during pregnancy. During the first trimester, the combination of PlGF with clinical, biophysical and biological factors results in a better test than the conventional one. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.10.005DOI Listing
March 2019
3 Reads

Biomechanical response of a novel intervertebral disc prosthesis using functionally graded polymers: A finite element study.

J Mech Behav Biomed Mater 2019 Feb 20;94:288-297. Epub 2019 Feb 20.

Ramsay Générale de Santé, Hôpital privé Le Bois, 59000 Lille, France.

With their gradual and continuous properties, functionally graded polymers (FGP) have high potentials to reproduce the regional variation in microstructure/property of the natural intervertebral disc and, therefore, the functional anatomy and biomechanics of the soft tissue. This paper evaluates by finite element analysis the biomechanical response and stress distribution of a novel disc prosthesis using FGP. The kinetics of the FGP parameters is designed using experimental data issued from linear ethylene copolymers over a wide crystallinity range. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.021DOI Listing
February 2019

Elastic Scattering Time of Matter Waves in Disordered Potentials.

Phys Rev Lett 2019 Mar;122(10):100403

Laboratoire Charles Fabry, Institut d'Optique, CNRS, Université Paris-Saclay, 91127 Palaiseau cedex, France.

We report on an extensive study of the elastic scattering time τ_{s} of matter waves in optical disordered potentials. Using direct experimental measurements, numerical simulations, and comparison with the first-order Born approximation based on the knowledge of the disorder properties, we explore the behavior of τ_{s} over more than 3 orders of magnitude, ranging from the weak to the strong scattering regime. We study in detail the location of the crossover and, as a main result, we reveal the strong influence of the disorder statistics, especially on the relevance of the widely used Ioffe-Regel-like criterion kl_{s}∼1. Read More

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https://link.aps.org/doi/10.1103/PhysRevLett.122.100403
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http://dx.doi.org/10.1103/PhysRevLett.122.100403DOI Listing
March 2019
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Cyclone avoidance behaviour by foraging seabirds.

Sci Rep 2019 Apr 1;9(1):5400. Epub 2019 Apr 1.

Centre d'Etudes Biologiques de Chizé, CNRS, 79360, Villiers en Bois, France.

In the context of climate change, how extreme climatic events, such as cyclones, will affect the foraging abilities of marine vertebrates is still poorly known. During the course of a study on the foraging behaviour of two tropical seabirds, red-footed boobies and great frigatebirds, several cyclones have affected their breeding grounds and foraging zones, allowing us to study their response to extreme wind conditions. We examined whether adults and young naïve birds were able to predict the arrival of a cyclone and behave accordingly to reduce mortality risks and optimise foraging. Read More

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http://dx.doi.org/10.1038/s41598-019-41481-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443659PMC

AA16, a new lytic polysaccharide monooxygenase family identified in fungal secretomes.

Biotechnol Biofuels 2019 16;12:55. Epub 2019 Mar 16.

1Biodiversité et Biotechnologie Fongiques, UMR1163, INRA, Aix Marseille Université, Marseille, France.

Background: Lignocellulosic biomass is considered as a promising alternative to fossil resources for the production of fuels, materials and chemicals. Efficient enzymatic systems are needed to degrade the plant cell wall and overcome its recalcitrance. A widely used producer of cellulolytic cocktails is the ascomycete , but this organism secretes a limited set of enzymes. Read More

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http://dx.doi.org/10.1186/s13068-019-1394-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420742PMC

First experience of durable cytoreduction in chronic lymphoid leukemia with Lu-DOTATATE.

Med Oncol 2019 Mar 27;36(5):41. Epub 2019 Mar 27.

Nuclear Medicine Department and Molecular Imaging, CHUV, Rue du Bugnon 46, 1011, Lausanne, Switzerland.

This is the first described case of effective and durable cytoreduction after PRRT with Lu-DOTATATE in a 75-year-old female, with B cell chronic lymphoid leukemia, and well-differentiated metastatic neuroendocrine tumor. Read More

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http://dx.doi.org/10.1007/s12032-019-1266-0DOI Listing

Divergent Entry to C-Glycosides from Unprotected Sugars.

Org Lett 2019 Mar 27. Epub 2019 Mar 27.

L'Oréal Research & Innovation , 1 av. Eugène Schueller , 93600 Aulnay-sous-Bois , France.

An efficient, divergent, and straightforward access to novel C-glycosides has been developed, namely, α-hydroxy carboxamide and carboxylic acid derivatives, via a green and scalable process from unprotected carbohydrates. The method involves condensation of 1,3-dimethylbarbituric acid with unprotected sugars followed by subsequent barbiturate oxidative cleavage in the same pot. Further expanding of the chemistry led to the development of efficient entries to diastereoisomerically pure C-glycosyl-α-hydroxy esters or amides through nucleophilic attack on a readily available and versatile key lactone intermediate. Read More

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http://pubs.acs.org/doi/10.1021/acs.orglett.9b00666
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http://dx.doi.org/10.1021/acs.orglett.9b00666DOI Listing
March 2019
2 Reads

Early treatment modifications improve chemotherapy adherence in ovarian cancer patients ≥70 years.

Gynecol Oncol 2019 Mar 21. Epub 2019 Mar 21.

Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Kiel, Germany; Onkologisches Therapiezentrum, Krankenhaus Jerusalem, Hamburg, Germany.

Objective: Elderly ovarian cancer patients are underrepresented in clinical trials and disadvantaged with regard to therapeutic standards compared to other age groups. We explored the specific performance of a subset of patients aged ≥70 years in a large meta-data set of 3 phase III trials.

Methods: 3333 patients with advanced ovarian cancer recruited into 3 clinical phase III trials of the AGO & GINECO study groups were retrospectively analysed for age-specific prognostic and toxicity parameters. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.015DOI Listing
March 2019
2 Reads

[Assessment of muscular toxicity due to chemotherapy by cardio-pulmonary exercise testing].

Rev Mal Respir 2019 Mar 19;36(3):364-368. Epub 2019 Mar 19.

Unité de physiologie respiratoire et sportive, hôpitaux de Rouen, CHU, hôpitaux de Rouen, CHU, 1, rue de Germont, 76031 Rouen, France.

Introduction: Cardio-pulmonary exercise testing (CPET) is frequently used to assess aerobic capacity, to evaluate respiratory tolerance and to provide prognostic information. Therefore, CPET is often incorporated in the preoperative assessment of cancer patients. This clinical case report presents the preoperative assessment of a patient before thoracic surgery, in whom an important decrease of aerobic capacity was noted, possibly because of muscular toxicity linked to chemotherapy. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.11.006DOI Listing
March 2019
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Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy.

J Transl Med 2019 Mar 22;17(1):97. Epub 2019 Mar 22.

Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, 08854, USA.

Background: OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly soluble (BCS Class II drug). In order to be feasible for low and middle income countries (LMICs), any process to create or formulate such a therapeutic must be inexpensive at scale, and the resulting formulation must survive without refrigeration even in hot, humid climates. Read More

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http://dx.doi.org/10.1186/s12967-019-1849-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431012PMC

Two successful decades of Swiss collaborations to develop new anti-malarials.

Malar J 2019 Mar 22;18(1):94. Epub 2019 Mar 22.

Swiss Tropical & Public Health Institute, Socinstrasse 57, 4002, Basel, Switzerland.

Over the last two decades there has been a renaissance in the pipeline of new drugs targeting malaria, with the launch of new products that help save the lives of children throughout the world. In addition, there is a wealth of new molecules both entering and progressing through clinical development. These bring hope for a new generation of simpler and more effective cures that could overcome the emerging threat of drug resistance. Read More

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http://dx.doi.org/10.1186/s12936-019-2728-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431002PMC

Outcome of Frail Do-Not-Intubate Subjects With End-Stage Chronic Respiratory Failure and Their Opinion of Noninvasive Ventilation to Reverse Hypercapnic Coma.

Respir Care 2019 Mar 19. Epub 2019 Mar 19.

Department of Respiratory and Critical Care Medicine, Schaffner Hospital, Lens, France.

Background: The use of noninvasive ventilation (NIV) in the emergency setting to reverse hypercapnic coma in frail patients with end-stage chronic respiratory failure and do-not-intubate orders remains a questionable issue given the poor outcome of this vulnerable population. We aimed to answer this issue by assessing not only subjects' outcome with NIV but also subjects' point of view regarding NIV for this indication.

Methods: A prospective observational case-control study was conducted in 3 French tertiary care hospitals during a 2-y period. Read More

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http://dx.doi.org/10.4187/respcare.06346DOI Listing
March 2019
2 Reads

Vitamin C Prevents Ultraviolet-induced Pigmentation in Healthy Volunteers: Bayesian Meta-analysis Results from 31 Randomized Controlled versus Vehicle Clinical Studies.

J Clin Aesthet Dermatol 2019 Feb 1;12(2):E53-E59. Epub 2019 Feb 1.

Drs. de Dormael and Bastien contributed equally to this article.

Repeated nonextreme sun exposures induce skin pigmentation by increasing melanin production and by oxidizing preexisting melanin and melanin precursors. This leads to skin disorders and skin color heterogeneity such as hyperpigmented spots. We assessed 31 randomized, controlled clinical trials to determine the potential of vitamin C to limit ultraviolet (UV) daylight-induced pigmentation, considering dose response and different skin type populations (Caucasian and Chinese). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415704PMC
February 2019
1 Read

Chronic UVA1 irradiation of human dermal fibroblasts: persistence of DNA damage and validation of a cell-cultured based model of photoaging.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Centre de Recherche du CHU de Québec - Université Laval, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, Canada; Université Laval, Faculté de Médecine, Département d'Ophtalmologie, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.02.022DOI Listing

Haeckel and du Bois-Reymond: rival German Darwinists.

Theory Biosci 2019 Mar 13. Epub 2019 Mar 13.

Department of History, University of Colorado Denver, PO Box 173364, Denver, CO, 80217-3364, USA.

Ernst Haeckel and Emil du Bois-Reymond were the most prominent champions of Darwin in Germany. This essay compares their contributions to popularizing the theory of evolution, drawing special attention to the neglected figure of du Bois-Reymond as a spokesman for a world devoid of natural purpose. It suggests that the historiography of the German reception of Darwin's theory needs to be reassessed in the light of du Bois-Reymond's Lucretian outlook. Read More

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http://dx.doi.org/10.1007/s12064-019-00282-6DOI Listing
March 2019
1.226 Impact Factor

In-depth transcriptome characterization uncovers distinct gene family expansions for Cupressus gigantea important to this long-lived species' adaptability to environmental cues.

BMC Genomics 2019 Mar 13;20(1):213. Epub 2019 Mar 13.

Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Laboratory for Tree Breeding, Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, 100083, China.

Background: Cupressus gigantea, a rare and endangered tree species with remarkable medicinal value, is endemic to the Tibetan Plateau. Yet, little is known about the underlying genetics of the unique ecological adaptability of this extremely long-lived conifer with a large genome size. Here, we present its first de novo and multi-tissue transcriptome in-depth characterization. Read More

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http://dx.doi.org/10.1186/s12864-019-5584-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417167PMC

Pain coping strategies in children with cerebral palsy.

Dev Med Child Neurol 2019 Mar 10. Epub 2019 Mar 10.

CMCR des Massues - Croix-Rouge Française, Lyon, France.

Aim: To describe coping strategies in children and adolescents with cerebral palsy (CP), relative to age.

Method: Patients were prospectively recruited from two paediatric rehabilitation centres in France. The Pediatric Pain Coping Inventory - French and Structured Pain Questionnaire were completed by an experienced professional for each child. Read More

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http://dx.doi.org/10.1111/dmcn.14204DOI Listing
March 2019
5 Reads

Temperature and Pressure Dependent Rate Coefficients for the Reaction of Ketene with Hydroxyl Radical.

J Phys Chem A 2019 Apr 25;123(13):2483-2496. Epub 2019 Mar 25.

Unité Chimie et Procédés (UCP) , ENSTA ParisTech , 828 Boulevard des Maréchaux , 91120 Palaiseau , France.

The reaction of ketene with hydroxyl radical is drawing growing attention, for it is found to constitute an important step during the combustion of hydrocarbon and oxygenated hydrocarbon fuels, e.g., acetylene, propyne, allene, acetone, gasoline, diesel, jet fuels, and biofuels. Read More

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http://pubs.acs.org/doi/10.1021/acs.jpca.8b11273
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http://dx.doi.org/10.1021/acs.jpca.8b11273DOI Listing
April 2019
2 Reads

The structural characterization and antioxidant properties of oil palm fronds lignin incorporated with p-hydroxyacetophenone.

Int J Biol Macromol 2019 Jun 6;130:947-957. Epub 2019 Mar 6.

Materials Technology Research Group (MaTReC), School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia. Electronic address:

This study reports on the effects of unmodified autohydrolyzed ethanol organosolv lignin (AH EOL) and modified autohydrolyzed ethanol organosolv lignin on the structural characteristics and antioxidant properties upon incorporation of p-hydroxyacetophenone (AHP EOL). The lignin samples isolated from black liquor of oil palm fronds (OPF) were evaluated and compared using various complementary analyses; FTIR, H and C NMR spectroscopy, 2D-NMR spectroscopy (HMBC and HSQC), CHN, GPC, HPLC and thermal analyses (TGA and DSC). Chemically modified organosolv lignin (AHP EOL) provided lignin with lower molecular weight (M), which has smaller fragments that leads to higher solubility rate in water in comparison to unmodified organosolv lignin, AH EOL (D: 19. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.03.032DOI Listing
June 2019
3 Reads

Evergreenness influences fine root growth more than tree diversity in a common garden experiment.

Oecologia 2019 Mar 9. Epub 2019 Mar 9.

Centre for Forest Research, Université du Québec à Montréal, PO Box 8888, Centre-Ville Station, Montréal, QC, H3C 3P8, Canada.

Recent studies have reported positive net diversity effects on aboveground tree growth. However, whether similar effects occur belowground through root investment, and whether such effects are related to evergreenness of tree communities, is less clear. Here we studied vertical distribution of standing fine root biomass of twelve North American temperate tree species planted in a common garden tree diversity experiment of varying species richness and evergreenness to test whether belowground niche complementarity of trees could explain positive diversity effects reported aboveground. Read More

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http://dx.doi.org/10.1007/s00442-019-04373-5DOI Listing

Sensitive Skin in the Indian Population: An Epidemiological Approach.

Front Med (Lausanne) 2019 20;6:29. Epub 2019 Feb 20.

EMMA, Direction Scientifique, Fontenay sous Bois, France.

Sensitive skin is a very frequent condition, the prevalence of this syndrome has been studied in different countries in Europe, in United States and in Japan. The aim of the study was to evaluate the epidemiology of sensitive skin in the Indian population, like this has never been studied in this country. A representative nationwide sample of the Indian population aged 15 and over was selected. Read More

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https://www.frontiersin.org/article/10.3389/fmed.2019.00029/
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http://dx.doi.org/10.3389/fmed.2019.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391320PMC
February 2019
3 Reads

Plasmodium knowlesi exhibits distinct in vitro drug susceptibility profiles from those of Plasmodium falciparum.

Int J Parasitol Drugs Drug Resist 2019 Apr 22;9:93-99. Epub 2019 Feb 22.

Department of Immunology & Infection, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK; Department of Clinical Parasitology, Hospital for Tropical Diseases, Mortimer Market Centre, Capper Street, London, WC1E 6JB, UK.

New antimalarial agents are identified and developed after extensive testing on Plasmodium falciparum parasites that can be grown in vitro. These susceptibility studies are important to inform lead optimisation and support further drug development. Until recently, little was known about the susceptibility of non-falciparum species as these had not been adapted to in vitro culture. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113207183018
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http://dx.doi.org/10.1016/j.ijpddr.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403410PMC
April 2019
7 Reads

Post-natal corticosterone exposure affects ornaments in adult male house sparrows (Passer domesticus).

Gen Comp Endocrinol 2019 05 1;276:45-51. Epub 2019 Mar 1.

Centre d'Etudes Biologiques de Chizé, CNRS-ULR, UMR 7372, 79360 Villiers en Bois, France.

In vertebrates, the ontogeny of several crucial organismal systems is known to occur early in life. Developmental conditions can ultimately have important consequences on adult fitness by affecting individual phenotype. These developmental effects are thought to be primarily mediated by endocrine systems, and especially by glucocorticoids. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.02.021DOI Listing

Impact of Ferroquine on the Solubilization of Artefenomel (OZ439) during in Vitro Lipolysis in Milk and Implications for Oral Combination Therapy for Malaria.

Mol Pharm 2019 Apr 4;16(4):1658-1668. Epub 2019 Mar 4.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences , Monash University (Parkville Campus) , 381 Royal Parade , Parkville , VIC 3052 , Australia.

Milk is an attractive lipid-based formulation for the delivery of poorly water-soluble drugs to pediatric populations. We recently observed that solubilization of artefenomel (OZ439) during in vitro intestinal lipolysis was driven by digestion of triglycerides in full-cream bovine milk, reflecting the ability of milk to act as an enabling formulation in the clinic. However, when OZ439 was co-administered with a second antimalarial drug, ferroquine (FQ) the exposure of OZ439 was reduced. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448114PMC
April 2019
15 Reads

How to Assess Executive Functions in a Low-Educated and Multicultural Population Using a Switching Verbal Fluency Test (the TFA-93) in Neurodegenerative Diseases?

Am J Alzheimers Dis Other Demen 2019 Mar 3:1533317519833844. Epub 2019 Mar 3.

1 Equipe Neuropsychologie du Vieillissement (EA 4468), Institut de Psychologie, Université Paris Descartes, Boulogne-Billancourt, France.

Few neuropsychological tests are available to assess executive dysfunction in low-educated and multicultural populations. To address this issue, the TFA-93, a switching verbal fluency test to assess cognitive flexibility, was administered to 70 healthy controls, 57 patients with a clinical diagnosis of Alzheimer's disease, and 21 with a clinical diagnosis of a neurodegenerative disease associated with frontal disorders. Most of the participants were low-educated and nonnative French speakers. Read More

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http://journals.sagepub.com/doi/10.1177/1533317519833844
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http://dx.doi.org/10.1177/1533317519833844DOI Listing
March 2019
4 Reads

PET/CT Evaluation of Cardiac Sarcoidosis.

PET Clin 2019 Apr 1;14(2):223-232. Epub 2019 Feb 1.

Department of Cardiovascular Diseases, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

The increasing implementation of advanced cardiovascular imaging in the form of cardiac PET/CT has had a significant impact on the management of cardiac sarcoidosis, which continues to evolve. This review summarizes the role of PET/CT imaging in sarcoidosis with a specific focus on (1) indications, (2) patient preparation, (3) test performance, (4) study interpretation, (5) clinical relevance of findings, (6) comparison to alternative imaging modalities, and finally (7) introduction of areas of anticipated development and research. Read More

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http://dx.doi.org/10.1016/j.cpet.2018.12.004DOI Listing
April 2019
5 Reads

Environmental causes and reproductive correlates of mercury contamination in European pond turtles (Emys orbicularis).

Environ Res 2019 Jan 26;172:338-344. Epub 2019 Jan 26.

Centre d'Etudes Biologiques de Chizé, CEBC UMR 7372 CNRS-Université de La Rochelle, 79360 Villiers en Bois, France.

Assessing Hg contamination in aquatic ecosystems is difficult because wetlands are part of large and complex networks, and potential sources of Hg contamination are highly diverse. To investigate environmental determinants of Hg contamination, we studied one of the largest continental French wetlands structured as a dense network of artificial ponds. Such context allows to investigate the influence of pond characteristics on Hg contamination in an area relatively disconnected from direct sources of pollution. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00139351193004
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http://dx.doi.org/10.1016/j.envres.2019.01.043DOI Listing
January 2019
2 Reads

Exposure of breeding albatrosses to the agent of avian cholera: dynamics of antibody levels and ecological implications.

Oecologia 2019 Feb 28. Epub 2019 Feb 28.

Centre d'Écologie Fonctionnelle et Évolutive (CEFE), UMR CNRS 5175, University of Montpellier, EPHE, University Paul Valéry Montpellier 3, IRD, Montpellier, France.

Despite critical implications for disease dynamics and surveillance in wild long-lived species, the immune response after exposure to potentially highly pathogenic bacterial disease agents is still poorly known. Among infectious diseases threatening wild populations, avian cholera, caused by the bacterium Pasteurella multocida, is a major concern. It frequently causes massive mortality events in wild populations, notably affecting nestlings of Indian yellow-nosed albatrosses (Thalassarche carteri) in the Indian Ocean. Read More

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http://link.springer.com/10.1007/s00442-019-04369-1
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http://dx.doi.org/10.1007/s00442-019-04369-1DOI Listing
February 2019
4 Reads

Development of a defined approach for eye irritation or serious eye damage for liquids, neat and in dilution, based on cosmetics Europe analysis of in vitro STE and BCOP test methods.

Toxicol In Vitro 2019 Jun 26;57:154-163. Epub 2019 Feb 26.

The Procter & Gamble Company, Egham, United Kingdom.

The focus of Cosmetics Europe's programme on serious eye damage/eye irritation is on development of testing strategies and defined approaches for identification of ocular effects of chemicals in the context of OECD's Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation. Cosmetics Europe created a comprehensive database of chemicals for which in vitro data are available with corresponding historical in vivo Draize eye data. This database allowed further exploration of the initially proposed strategies from the CON4EI project and to identify opportunities for refinement. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.019DOI Listing

Developing a Clinico-Molecular Test for Individualized Treatment of Ovarian Cancer: The interplay of Precision Medicine Informatics with Clinical and Health Economics Dimensions.

AMIA Annu Symp Proc 2018 5;2018:1093-1102. Epub 2018 Dec 5.

Institute for Health Informatics, University of Minnesota, MN, USA.

We report recent progress in the development of a precision test for individualized use of the VEGF-A targeting drug bevacizumab for treating ovarian cancer. We discuss the discovery model stage (i.e. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371365PMC
December 2018
2 Reads

A Randomized Trial of Lymphadenectomy in Patients with Advanced Ovarian Neoplasms.

N Engl J Med 2019 02;380(9):822-832

From the Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen (P. Harter, A. du Bois), Department of Gynecology, Charité-Universitätsmedizin Berlin, Berlin (J.S.), the Coordinating Center for Clinical Trials, Philipps University Marburg (A.R., C.S.-B.), and the Department of Gynecology and Obstetrics, University Hospital Giessen and Marburg (U.W.), Marburg, the Department of Gynecology and Obstetrics, Kaiserswerther Diakonie (B.L.), and the Department of Obstetrics and Gynecology, Heinrich-Heine-University Düsseldorf (W.M.), Düsseldorf, the Department of Gynecology and Obstetrics, University Medicine Greifswald, Greifswald (A.M.), the Department of Gynecology, University Medical Center Hamburg-Eppendorf (S.M.), and the Department of Gynecology and Obstetrics, Albertinen Krankenhaus (I.L.), Hamburg, University Women's Hospital, Department of Gynecology and Reproductive Medicine and Center for Gynecologic Oncology, Jena University Hospital, Jena (I.B.R.), the Department of Obstetrics and Gynecology, University Munich rechts der Isar (B.S.), and the Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-Universität München (A. Burges), Munich, West German Cancer Center, Department of Gynecology and Obstetrics, University of Duisburg-Essen, Duisburg (R.K.), the Department of Gynecology and Obstetrics, University Hospital Kiel, Kiel (F.H.), University Medical Center Freiburg, Freiburg (A.H.), University Medical Center Mainz, Department of Gynecology and Obstetrics, Mainz (A.H.), and the Department of Gynecology and Obstetrics, Hannover Medical School, Hannover (P. Hillemanns) - all in Germany; the Gynecologic Oncology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori (D.L., F.R.), and the Department of Gynecologic Oncology, European Institute of Oncology, University of Milan (G.A.), Milan, the Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome (G.S.), Gynecologic Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori di Napoli, IRCCS Fondazione G. Pascale, Naples (S.G.), and the Cancer Reference Center, Centro di Riferimento Oncologico, Aviano (G.G.) - all in Italy; the Department of Gynecological Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium (I.V.); the Department of Obstetrics and Gynecology, Medical University Innsbruck, Innsbruck, Austria (C.M.); the Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea (J.-W.K.); and the Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic (D.C.).

Background: Systematic pelvic and paraaortic lymphadenectomy has been widely used in the surgical treatment of patients with advanced ovarian cancer, although supporting evidence from randomized clinical trials has been limited.

Methods: We intraoperatively randomly assigned patients with newly diagnosed advanced ovarian cancer (International Federation of Gynecology and Obstetrics stage IIB through IV) who had undergone macroscopically complete resection and had normal lymph nodes both before and during surgery to either undergo or not undergo lymphadenectomy. All centers had to qualify with regard to surgical skills before participation in the trial. Read More

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http://dx.doi.org/10.1056/NEJMoa1808424DOI Listing
February 2019
5 Reads