1,418 results match your criteria Body Fluid Exposures


Sex and Gender Role Differences in Occupational Exposures and Work Outcomes Among Registered Nurses in Correctional Settings.

Ann Work Expo Health 2019 Mar 30. Epub 2019 Mar 30.

StayWell Health Center, Waterbury, CT, USA.

Background And Context: The correctional environment exposes registered nurses to unique occupational health hazards including, but not limited to, an increased risk for workplace violence. Gender role expectations regarding femininity and masculinity may influence occupational exposures and outcomes differently. Risk comparisons between male and female registered nurses working in correctional settings, have been minimally examined. Read More

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http://dx.doi.org/10.1093/annweh/wxz018DOI Listing

Adductomics: a promising tool for the verification of chemical warfare agents' exposures in biological samples.

Arch Toxicol 2019 Mar 28. Epub 2019 Mar 28.

Vertox Biochemistry Division, DRDE, Gwalior, India.

Humans are constantly exposed to a wide range of reactive and toxic chemicals from the different sources in everyday life. Identification of the exposed chemical helps in the detection and understanding the exposure associated adverse health effects. Covalent adducts of proteins and DNA formed after xenobiotics exposure may serve as readily measurable indicators of these exposures. Read More

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http://dx.doi.org/10.1007/s00204-019-02435-4DOI Listing
March 2019
5.980 Impact Factor

Bloodborne Pathogens Standard Enforcement at the Occupational Safety and Health Administration: The First Twenty-Five Years.

New Solut 2019 Mar 27:1048291119840077. Epub 2019 Mar 27.

3 Occupational Safety and Health Administration, Washington, DC, USA.

Bloodborne pathogen exposures continue to be an occupational health concern of high importance. It is uncertain whether national regulations and enforcement have an impact on employer action for reducing risk. The goal of this research was to determine whether citations issued under the Occupational Safety and Health Administration's Bloodborne Pathogens Standard changed over time given these changing risks and controls. Read More

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http://dx.doi.org/10.1177/1048291119840077DOI Listing
March 2019
1 Read

Two-month point prevalence of exposure to critical incidents in firefighters in a single fire service.

Work 2019 ;62(3):477-483

School of Rehabilitation Therapy & Canadian Institute for Military & Veteran Health Research (CIMVHR), Queen's University, Kingston, Ontario, Canada.

Background: Firefighters have high rates of exposures to critical events that contribute to physical and mental stress, resulting in high rates of injury and work-injury compensation claims.

Objective: To determine the prevalence of critical incidents in firefighters from a single fire service, and whether the number of critical events varied based on age, gender, years of service and/or rank.

Methods: We recruited 300 full-time firefighters. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/WOR-192882DOI Listing
January 2019
2 Reads

The influence of maternal and perinatal high-fat diet on ozone-induced pulmonary responses in offspring.

J Toxicol Environ Health A 2019 12;82(2):86-98. Epub 2019 Feb 12.

a Environmental Public Health Division , US Environmental Protection Agency , Durham , NC , USA.

There is growing interest in understanding how maternal diet might affect the sensitivity of offspring to environmental exposures. Previous studies demonstrated that adult rat offspring (approximately 6-months-old) from dams given a high-fat diet (HFD) prior to, during, and after pregnancy displayed elevated pulmonary responses to an acute ozone (O) exposure. The aim of this study was to examine the influence of maternal and perinatal HFD on pulmonary and metabolic responses to O in male and female young-adult offspring (approximately 3-month old). Read More

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http://dx.doi.org/10.1080/15287394.2018.1564101DOI Listing
February 2019
1 Read

Prenatal exposure to perfluoroalkyl substances is associated with lower hand, foot and mouth disease viruses antibody response in infancy: Findings from the Guangzhou Birth Cohort Study.

Sci Total Environ 2019 May 26;663:60-67. Epub 2019 Jan 26.

Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: Perfluoroalkyl substances (PFASs) are synthetic chemicals widely used in industry and for commercial products. Their immunomodulatory effects are a growing health concern in children. Hand, Foot and Mouth Disease (HFMD) is a common childhood viral infection, and increased incidence of which has parallel the rise in PFAS exposure in the Asia-Pacific region. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.325DOI Listing
May 2019
2 Reads

A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid and Plasma Concentrations of Cefepime.

mSphere 2019 01 30;4(1). Epub 2019 Jan 30.

Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA

This study sought to define the transit of cefepime between plasma and cerebral spinal fluid (CSF) in a rat model. Male Sprague-Dawley rats received cefepime intravenously. A total daily dose of 150 mg/kg of body weight/day was administered as a single injection every 24 h for 4 days. Read More

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http://dx.doi.org/10.1128/mSphere.00595-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354808PMC
January 2019
1 Read

Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy.

Environ Health 2019 01 9;18(1). Epub 2019 Jan 9.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.

Background: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been reported to disrupt endocrine system and reproduction. However, epidemiological evidence on the association between PFAS and preeclampsia is inconsistent. We aimed to investigate the association between prenatal PFAS exposure and hypertensive disorders of pregnancy (HDP) in humans. Read More

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https://ehjournal.biomedcentral.com/articles/10.1186/s12940-
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http://dx.doi.org/10.1186/s12940-018-0445-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327470PMC
January 2019
15 Reads

Cord blood perfluoroalkyl substances in mothers exposed to the World Trade Center disaster during pregnancy.

Environ Pollut 2019 Mar 11;246:482-490. Epub 2018 Dec 11.

Columbia Center for Children's Environmental Health, Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.

Perfluoroalkyl substances (PFAS) may have been released during the collapse of the World Trade Center (WTC) on 9/11. Evidence suggests PFAS can cross the placental barrier in humans and cause harm to the developing fetus; however, no studies have measured PFAS in mothers exposed to the WTC disaster during pregnancy. We measured PFAS in maternal plasma (n = 48) or cord blood (n = 231) from pregnant women in the Columbia University WTC birth cohort, enrolled between December 13, 2001 and June 26, 2002 at one of three hospitals located near the WTC site. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183406
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http://dx.doi.org/10.1016/j.envpol.2018.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402332PMC
March 2019
10 Reads

Partitional calorimetry.

J Appl Physiol (1985) 2019 Feb 29;126(2):267-277. Epub 2018 Nov 29.

Thermal Ergonomics Laboratory, Faculty of Health Sciences, The University of Sydney , Sydney, NSW , Australia.

For thermal physiologists, calorimetry is an important methodological tool to assess human heat balance during heat or cold exposures. A whole body direct calorimeter remains the gold standard instrument for assessing human heat balance; however, this equipment is rarely available to most researchers. A more widely accessible substitute is partitional calorimetry, a method by which all components of the conceptual heat balance equation-metabolic heat production, conduction, radiation, convection, and evaporation-are calculated separately based on fundamental properties of energy exchange. Read More

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http://dx.doi.org/10.1152/japplphysiol.00191.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397408PMC
February 2019
1 Read

Maternal stress and placental function, a study using questionnaires and biomarkers at birth.

PLoS One 2018 15;13(11):e0207184. Epub 2018 Nov 15.

Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Background: Prenatal stress affects the health of the pregnant woman and the fetus. Cortisol blood levels are elevated in pregnancy, and fetal exposure to cortisol is regulated by the placenta enzyme 11β-HSD2. A decrease in enzyme activity allows more maternal cortisol to pass through the placental barrier. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207184PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237336PMC
April 2019
17 Reads

Metabolomics in the study of retinal health and disease.

Prog Retin Eye Res 2019 03 10;69:57-79. Epub 2018 Nov 10.

Retina Service, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, United States. Electronic address:

Metabolomics is the qualitative and quantitative assessment of the metabolites (small molecules < 1.5 kDa) in body fluids. The metabolites are the downstream of the genetic transcription and translation processes and also downstream of the interactions with environmental exposures; thus, they are thought to closely relate to the phenotype, especially for multifactorial diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13509462183002
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http://dx.doi.org/10.1016/j.preteyeres.2018.11.002DOI Listing
March 2019
22 Reads

Consideration of Occult Infection and Sepsis Mimics in the Sick Patient Without an Apparent Infectious Source.

J Emerg Med 2019 Jan 2;56(1):36-45. Epub 2018 Nov 2.

Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas.

Background: Evaluation and treatment of the acutely ill patient is typically complicated by multiple comorbidities and incomplete medical histories. This is exemplified by patients with sepsis, whose care is complicated by variable presentations, shifting definitions, and a variety of potential sources. Many practitioners fail to consider and recognize less-common sources of infection in a timely manner. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679183095
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http://dx.doi.org/10.1016/j.jemermed.2018.09.035DOI Listing
January 2019
9 Reads

The associations of workload, individual and organisational factors on nurses' occupational injuries.

J Clin Nurs 2019 Mar 8;28(5-6):902-911. Epub 2018 Nov 8.

Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran.

Aims And Objectives: To determine the prevalence and type of occupational injuries in nurses and their associations with workload, working shift, and nurses' individual and organisational factors.

Background: Nurses are vulnerable to occupational injuries due to the nature of their job.

Design: A cross-sectional correlational design (based on STROBE Statement) was conducted. Read More

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http://dx.doi.org/10.1111/jocn.14699DOI Listing
March 2019
26 Reads
1.233 Impact Factor

[Occupational and non occupational exposure to viral risk].

Rev Med Interne 2019 Apr 5;40(4):238-245. Epub 2018 Oct 5.

Service de médecine interne, hôpital Ambroise-Paré, HUPIFO, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne, France; UFR Paris Île-de-France Ouest, université Versailles Saint-Quentin-en-Yvelines, 78180 Versailles, France; GERES, UFR de médecine Bichat, 16, rue Henri-Huchart, 75018 Paris, France. Electronic address:

The transmission of an infectious disease can occur through exposure to blood or other potentially infectious body fluids, particularly in the event of skin-puncture injuries for healthcare workers, and during sexual intercourse. These situations are known as accidental blood exposures and sexual exposures respectively. Combined actions carried out have allowed to significantly reduce risks, either to healthcare professionals (by standard precautions, provision of safety devices, Hepatitis B vaccination made compulsory in the 1990s, antiretroviral post-exposure prophylaxis that should be initiated as soon as possible after exposure), or to people engaging in unprotected sex (by prevention messages, condom promotion, and antiretroviral post-exposure prophylaxis). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02488663183070
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http://dx.doi.org/10.1016/j.revmed.2018.09.002DOI Listing
April 2019
3 Reads

Genetic diversity, infection prevalence, and possible transmission routes of Bartonella spp. in vampire bats.

PLoS Negl Trop Dis 2018 09 27;12(9):e0006786. Epub 2018 Sep 27.

Odum School of Ecology, University of Georgia, Athens, Georgia, United States of America.

Bartonella spp. are globally distributed bacteria that cause endocarditis in humans and domestic animals. Recent work has suggested bats as zoonotic reservoirs of some human Bartonella infections; however, the ecological and spatiotemporal patterns of infection in bats remain largely unknown. Read More

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https://dx.plos.org/10.1371/journal.pntd.0006786
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http://dx.doi.org/10.1371/journal.pntd.0006786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159870PMC
September 2018
17 Reads

Assessment of adherence behaviors for the self-reporting of occupational exposure to blood and body fluids among registered nurses: A cross-sectional study.

PLoS One 2018 26;13(9):e0202069. Epub 2018 Sep 26.

Department of Burns Surgery, Xiangya Hospital of Central South University, Changsha City, Hu'nan Province, China.

Background: In China, register nurses (RNs) have a high risk of occupational exposure to blood/body fluids. The adherence behavior related to self-reporting of occupational exposure needs to be evaluated to protect RNs from healthcare-related infections.

Objectives: To assess adherence behaviors for self-reporting of occupational exposure to blood and body fluids among RNs and identify factors affecting self-reporting in Hunan Province, China for developing upgraded strategies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202069PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157846PMC
February 2019
12 Reads

Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes.

Environ Pollut 2018 Dec 19;243(Pt B):1126-1133. Epub 2018 Sep 19.

Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, AState Key Laboratory of Environmental Health (incubating), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Prenatal disinfection by-products (DBPs) exposure is linked with adverse birth outcomes. Genetic susceptibility to DBP metabolism may modify the exposure-outcome associations.

Object: To investigate whether CYP2E1 and GSTZ1 genetic polymorphisms modified the associations of prenatal DBP exposures with adverse birth outcomes. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.09.083DOI Listing
December 2018
5 Reads

Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA).

Environ Health Perspect 2018 09;126(9):97006

1 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts, USA.

Background: Epigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health.

Objective: We sought to examine the associations of residential proximity to roadways at birth and epigenome-wide DNA methylation. We also assessed associations of differential methylation with child cognitive outcomes. Read More

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http://dx.doi.org/10.1289/EHP2034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375460PMC
September 2018
4 Reads

Identification and quantification of spinochromes in body compartments of 's coloured types.

R Soc Open Sci 2018 Aug 22;5(8):171213. Epub 2018 Aug 22.

Biology of Marine Organisms and Biomimetics Unit, Research Institute for Biosciences, University of Mons-UMONS, 23 Place du Parc, 7000 Mons, Belgium.

Sea urchin pigmentation is mainly due to polyhydroxy-1,4-naphthoquinones called spinochromes. If their molecular structures are well known in test and spines of many species, their abundance and distribution in other body compartments remain unstudied. The aim of this study is to analyse the pigment composition in four body compartments (test/spines, digestive system, gonads and coelomic fluid) of four coloured types of the sea urchin . Read More

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http://dx.doi.org/10.1098/rsos.171213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124065PMC
August 2018
19 Reads

Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence.

Environ Int 2018 12 9;121(Pt 1):159-168. Epub 2018 Sep 9.

Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China (Fudan University), China; Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address:

Objective: Metabolomics may unravel global metabolic changes in response to environmental exposures and identify important biological pathways involved in the pathophysiology of childhood obesity. Phthalate has been considered an obesogen and contributing to overweight and obesity in children. The purpose of this study is to evaluate changes in urine metabolites in response to the environmental phthalate exposure among overweight or obese children, and to investigate the metabolic mechanisms involved in the obesogenic effect of phthalate on children at puberty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183100
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http://dx.doi.org/10.1016/j.envint.2018.09.001DOI Listing
December 2018
3 Reads

Ambient air pollution, H19/DMR methylation in cord blood and newborn size: A pilot study in Zhengzhou City, China.

Chemosphere 2018 Dec 30;212:863-871. Epub 2018 Aug 30.

Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address:

Prenatal exposure to air pollutants is believed to be associated with adverse birth outcomes. However, the potential mechanisms, especially the epigenetic modified effects, still remain unclear. This study was designed to explore the association of air pollution, H19/DMR methylation levels, and birth weight and length. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.08.140DOI Listing
December 2018
12 Reads
3.340 Impact Factor

Mind the weather: a report on inter-annual variations in entomological data within a rural community under insecticide-treated wall lining installation in Kwara State, Nigeria.

Parasit Vectors 2018 Sep 4;11(1):497. Epub 2018 Sep 4.

Molecular Entomology and Vector Control Research Laboratory, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.

Background: Entomological indices within a specific area vary with climatic factors such as rainfall, temperature and relative humidity. Contributions of such weather parameter fluctuations to the changes in entomological data obtained within a community under implementation of a promising vector control intervention should be taken into account. This study reports on inter-annual changes in entomological indices within two rural communities, one of which was under insecticide-treated durable wall lining (DL) installation. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3078-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123909PMC
September 2018
12 Reads

Trend analysis and factors associated with biological injuries among health care workers in Southern Italy.

Med Lav 2018 Aug 28;109(4):308-315. Epub 2018 Aug 28.

University of L'Aquila.

Background: Biological injuries are the most common and serious among health care workers.

Objectives: This study aims to estimate the injuries' incidence, job distribution and temporal trend in a hospital in Southern Italy.

Methods: Data on accidents, collected from January 2010 to December 2016, were analyzed. Read More

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http://dx.doi.org/10.23749/mdl.v109i4.7245DOI Listing
August 2018
16 Reads

Global metabolomic responses in urine from atm deficient mice in response to LD gamma irradiation doses.

Environ Mol Mutagen 2018 08 10;59(7):576-585. Epub 2018 Aug 10.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia.

Exposures to ionizing radiation (IR) may either be accidental or intentional, for medical purposes or even through terrorist actions. As certain populations emerge to be more radiosensitive than others, it is imperative to assess those individuals and treat them accordingly. To demonstrate the feasibility of rapid identification of such cases, we utilized the highly radiosensitive mouse model Atm in the C57BL/6 background, and evaluated the urinary responses in 8-10 week old male mice at early time points (4, 24, and 72 h) after exposure to their respective LD doses [4 Gy for Atm , and 8 Gy for wild type (WT)]. Read More

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http://dx.doi.org/10.1002/em.22202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113093PMC
August 2018
5 Reads

Lead exposure biomarkers in the Common Loon.

Sci Total Environ 2019 Jan 4;647:639-644. Epub 2018 Aug 4.

Cummings School of Veterinary Medicine, Tufts University, N. Grafton, MA, United States of America.

Lead in fishing tackle is a significant source of exposure to the environment, wildlife, and potentially humans. Common Loons (Gavia immer) are exposed to lead by eating fish which have lead tackle, or ingesting fishing weights or spent ammunition when they ingest small stones to aid in digestion. Blood lead is traditionally used as a biomarker of exposure in loons, but it only reflects recent exposures. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.08.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168339PMC
January 2019
3 Reads

Epidemiological Characteristics of the Accidental Exposures to Blood-Borne Pathogens Among Workers in the Hospital.

Med Arch 2018 Jun;72(3):187-191

Clinic for Cardiovascular surgery, University Clinical Center Tuzla, Bosnia and Herzegovina.

Introduction: The main route of acquiring infectious blood and body fluids in hospital conditions is accidental exposure to stinging incidents.

Aim: The aim of this study was to determine the epidemiological characteristics of accidental exposures to blood-borne pathogens among different professional groups of health care workers (HCWs).

Materials And Methods: A cross-sectional study was conducted using the "Questionnaire on the HCWs exposure to blood and blood transmitted infections" at the University Clinical Centre Tuzla, Bosnia and Herzegovina, from the 1st of March to the 31st of December 2014. Read More

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http://dx.doi.org/10.5455/medarh.2018.72.187-191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021162PMC
June 2018
6 Reads

Dynamic Characteristics of Sequential Acute Exacerbations and Risk Windows in AECOPD Rats Induced by Cigarette-Smoke and Exposure to Klebsiella pneumoniae.

Biol Pharm Bull 2018 Oct 28;41(10):1543-1553. Epub 2018 Jul 28.

Collaborative Innovation Center for Respiratory Diseases Diagnostics, Treatment and New Drug Research and Development of Henan University of Traditional Chinese Medicine (TCM).

The risk-window (RW) of chronic obstructive pulmonary disease (COPD) is a period after an acute exacerbation (AE) but before the following stable phase, in which exacerbations are easy to relapse. We established a sequential COPD-AE-RW rat model by cigarette-smoke and bacterial exposures in the first 8 weeks, and was challenged with Klebsiella pneumonia to mimic an AE on Day 1 of week 9, and found that body temperature, white blood cell, neutrophils, serum amyloid A (SAA) and C-reactive protein (CRP) increased in AECOPD rats 24 h after challenge, and declined in 3-6 d, while lung function declined in 48 h, and recovered in 7-16 d. When sacrificed, pulmonary forced expiratory volume (FEV)100 and FEV300 decreased, while elevated bronchoalveolar lavage fluid (BALF) neutrophils and marked airway inflammation, remodeling and emphysema were observed. Read More

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https://www.jstage.jst.go.jp/article/bpb/41/10/41_b18-00148/
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http://dx.doi.org/10.1248/bpb.b18-00148DOI Listing
October 2018
5 Reads

[Survey of Anticancer Drug Exposure to Attendant Families in Pediatric Medical Centers].

Gan To Kagaku Ryoho 2018 Jun;45(6):945-948

Medical Center for Child Health, Dept. of Nursing, Kyushu University Hospital.

The occupational exposure to hazardous drugs(HD)has already been investigated; however, the actual exposure of the attendant family members of patients with childhood cancer has remained unknown. Here, we analyzed cyclophosphamide (CPM)exposure in attendant family members and the environment after the administration of CPM to patients with pediatric cancer. CPM of 320(8. Read More

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June 2018
2 Reads

Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques.

J Virol 2018 09 16;92(17). Epub 2018 Aug 16.

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Current approaches do not eliminate all human immunodeficiency virus type 1 (HIV-1) maternal-to-infant transmissions (MTIT); new prevention paradigms might help avert new infections. We administered maraviroc (MVC) to rhesus macaques (RMs) to block CCR5-mediated entry, followed by repeated oral exposure of a CCR5-dependent clone of simian immunodeficiency virus (SIV) mac251 (SIVmac766). MVC significantly blocked the CCR5 coreceptor in peripheral blood mononuclear cells and tissue cells. Read More

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http://dx.doi.org/10.1128/JVI.00576-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096825PMC
September 2018
10 Reads

Maternal and cord blood manganese (Mn) levels and birth weight: The MIREC birth cohort study.

Int J Hyg Environ Health 2018 07 7;221(6):876-882. Epub 2018 Jun 7.

Department of Environmental and Occupational Health, University of Montreal, Montreal, QC, H3C 3J7, Canada. Electronic address:

Epidemiological studies have hypothesized that both insufficient and excess blood manganese (Mn) levels during pregnancy are associated with reduced fetal growth. This literature is characterized by inconsistent results and a limited focus on women with exposures representative of the general North American population. We examined the relationship between maternal and cord blood Mn levels and fetal growth among women enrolled in the Maternal-Infant Research on Environmental Chemicals Study (MIREC). Read More

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http://dx.doi.org/10.1016/j.ijheh.2018.05.015DOI Listing
July 2018
3 Reads

Sex differences in effects of maternal risk and protective factors in childhood and pregnancy on newborn telomere length.

Psychoneuroendocrinology 2018 09 17;95:74-85. Epub 2018 May 17.

Department of Pediatrics, Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1198, New York City, NY 10029, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Little research has examined determinants of newborn telomere length, a potential biomarker of lifetime disease risk impacted by prenatal exposures. No study has examined whether maternal exposures in childhood influence newborn telomere length or whether there are sex differences in the maternal factors that influence newborn telomere length. We tested whether a range of maternal risk and protective factors in childhood and pregnancy were associated with newborn telomere length among 151 sociodemographically diverse mother-infant dyads. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2018.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109592PMC
September 2018
4 Reads

Recipes for simulated vomitus.

J Infect Prev 2018 May 20;19(3):141-143. Epub 2017 Nov 20.

School of Public Health, University of Illinois at Chicago, USA.

We developed and demonstrated the stability of recipes for simulated vomitus for use in experiments characterizing occupational exposures to body fluid during simulated healthcare activities. The recipes can be easily adapted to make other simulated bodily fluids at low costs and surrogates added to facilitate detection. Read More

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http://dx.doi.org/10.1177/1757177417741972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956701PMC

Experimental challenges regarding the in vitro investigation of the nanoparticle-biocorona in disease states.

Toxicol In Vitro 2018 Sep 5;51:40-49. Epub 2018 May 5.

School of Health Sciences, Purdue University, 550 Stadium Mall Dr, West Lafayette, IN 47907, United States. Electronic address:

Toxicological evaluation of nanoparticles (NPs) requires the utilization of in vitro techniques due to their number and diverse properties. Cell culture systems are often lacking in their ability to perform comparative toxicity assessment due to dosimetry issues and capacity to simulate in vivo environments. Upon encountering a physiological environment, NPs become coated with biomolecules forming a biocorona (BC), influencing function, biodistribution, and toxicity. Read More

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http://dx.doi.org/10.1016/j.tiv.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291017PMC
September 2018
1 Read

Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data.

Dev Cogn Neurosci 2018 Aug 16;32:97-106. Epub 2018 Mar 16.

Department of Pediatrics, Keck School of Medicine, University of Southern California, and Children's Hospital Los Angeles, Los Angeles, CA, USA. Electronic address:

Biospecimen collection in the Adolescent Brain Cognitive Development (ABCD) study - of hair samples, shed deciduous (baby) teeth, and body fluids - will serve dual functions of screening for study eligibility, and providing measures of biological processes thought to predict or correlate with key study outcomes on brain and cognitive development. Biosamples are being collected annually to screen for recency of drug use prior to the neuroimaging or cognitive testing visit, and to store for the following future studies: (1) on the effects of exposure to illicit and recreational drugs (including alcohol and nicotine); (2) of pubertal hormones on brain and cognitive developmental trajectories; (3) on the contribution of genomics and epigenomics to child and adolescent development and behavioral outcomes; and (4) with pre- and post-natal exposure to environmental neurotoxicants and drugs of abuse measured from novel tooth analyses. The present manuscript describes the rationales for inclusion and selection of the specific biospecimens, methodological considerations for each measure, future plans for assessment of biospecimens during follow-up visits, and preliminary ABCD data to illustrate methodological considerations. Read More

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http://dx.doi.org/10.1016/j.dcn.2018.03.005DOI Listing
August 2018
10 Reads

Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort.

Epigenetics 2018 16;13(3):290-300. Epub 2018 May 16.

a Division of Environmental Genetics and Molecular Toxicology.

Faroe islanders consume marine foods contaminated with methylmercury (MeHg), polychlorinated biphenyls (PCBs), and other toxicants associated with chronic disease risks. Differential DNA methylation at specific CpG sites in cord blood may serve as a surrogate biomarker of health impacts from chemical exposures. We aimed to identify key environmental chemicals in cord blood associated with DNA methylation changes in a population with elevated exposure to chemical mixtures. Read More

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http://dx.doi.org/10.1080/15592294.2018.1445901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997167PMC
February 2019
1 Read

Dairy product consumption and its association with metabolic disturbance in a prospective study of urban adults.

Br J Nutr 2018 03;119(6):706-719

1Laboratory of Epidemiology and Population Sciences,National Institute on Aging,National Institute on Aging, National Institutes of Health, Intramural Research Program,Baltimore,MD 21224,USA.

The role of dairy foods and related nutrients in cardiometabolic health aetiology is poorly understood. We investigated longitudinal associations between the metabolic syndrome (MetS) and its components with key dairy product exposures. We used prospective data from a bi-racial cohort of urban adults (30-64 years at baseline (n 1371)), the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS), in Baltimore City, MD (2004-2013). Read More

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http://dx.doi.org/10.1017/S0007114518000028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863589PMC
March 2018
2 Reads

Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.

Mult Scler 2019 Apr 13;25(5):661-668. Epub 2018 Mar 13.

Department of Neurology and Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Background:: The course of multiple sclerosis (MS) shows substantial inter-individual variability. The underlying determinants of disease severity likely involve genetic and environmental factors.

Objective:: The aim of this study was to assess the impact of APOE and HLA polymorphisms as well as smoking and body mass index (BMI) in the very early MS course. Read More

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http://journals.sagepub.com/doi/10.1177/1352458518763541
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http://dx.doi.org/10.1177/1352458518763541DOI Listing
April 2019
24 Reads

Maternal levels of endocrine disrupting chemicals in the first trimester of pregnancy are associated with infant cord blood DNA methylation.

Epigenetics 2018 18;13(3):301-309. Epub 2018 Apr 18.

a Department of Environmental Health Sciences, School of Public Health , University of Michigan , Ann Arbor , MI , USA.

Endocrine disrupting chemicals (EDCs) pose a public health risk through disruption of normal biological processes. Identifying toxicoepigenetic mechanisms of developmental exposure-induced effects for EDCs, such as phthalates or bisphenol A (BPA), is essential. Here, we investigate whether maternal exposure to EDCs is predictive of infant DNA methylation at candidate gene regions. Read More

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https://www.tandfonline.com/doi/full/10.1080/15592294.2018.1
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http://dx.doi.org/10.1080/15592294.2018.1448680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997152PMC
February 2019
1 Read

Neonatal intensive care unit phthalate exposure and preterm infant neurobehavioral performance.

PLoS One 2018 5;13(3):e0193835. Epub 2018 Mar 5.

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Every year in the United States, more than 300,000 infants are admitted to neonatal intensive care units (NICU) where they are exposed to a chemical-intensive hospital environment during a developmentally vulnerable period. The neurodevelopmental impact of environmental exposure to phthalates during the NICU stay is unknown. As phthalate exposure during the third trimester developmental window has been implicated in neurobehavioral deficits in term-born children that are strikingly similar to a phenotype of neurobehavioral morbidity common among children born premature, the role of early-life phthalate exposure on the neurodevelopmental trajectory of premature infants may be clinically important. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193835PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837295PMC
June 2018
7 Reads

Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation.

Epigenetics 2018 16;13(1):108-116. Epub 2018 Feb 16.

a Department of Epidemiology, School of Public Health , University of Michigan.

Cord blood DNA methylation is associated with numerous health outcomes and environmental exposures. Whole cord blood DNA reflects all nucleated blood cell types, while centrifuging whole blood separates red blood cells, generating a white blood cell buffy coat. Both sample types are used in DNA methylation studies. Read More

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http://dx.doi.org/10.1080/15592294.2017.1417710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836975PMC
December 2018
3 Reads

Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine.

Gut 2018 06 6;67(6):1168-1180. Epub 2018 Feb 6.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Immunotherapy strategies targeting immune checkpoints such as the and (programmed cell death 1 ligand 1, PD-L1)/ (programmed cell death 1, PD-1) T-cell coreceptor pathways are revolutionising oncology. The approval of pembrolizumab use for solid tumours with high-level microsatellite instability or mismatch repair deficiency by the US Food and Drug Administration highlights promise of precision immuno-oncology. However, despite evidence indicating influences of exogenous and endogenous factors such as diet, nutrients, alcohol, smoking, obesity, lifestyle, environmental exposures and microbiome on tumour-immune interactions, integrative analyses of those factors and immunity lag behind. Read More

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http://dx.doi.org/10.1136/gutjnl-2017-315537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943183PMC
June 2018
8 Reads

Maternal depression, antidepressant use and placental oxytocin receptor DNA methylation: Findings from the MPEWS study.

Psychoneuroendocrinology 2018 04 4;90:1-8. Epub 2018 Jan 4.

School of Psychology and Exercise Science, Murdoch University, Australia.

The aim of this study was to investigate placental DNA methylation of the oxytocin receptor gene (OXTR) in women with depression in pregnancy. We also explored the role of antidepressant medication in pregnancy on placental OXTR methylation. Data were obtained from 239 women in the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS), a selected pregnancy cohort. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2018.01.004DOI Listing
April 2018
10 Reads
4.944 Impact Factor

Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study.

J Proteome Res 2018 03 9;17(3):1235-1247. Epub 2018 Feb 9.

MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London , St. Mary's Campus, Norfolk Place, London W2 1PG, United Kingdom.

Birth weight is an important indicator of maternal and fetal health and a predictor of health in later life. However, the determinants of variance in birth weight are still poorly understood. We aimed to identify the biological pathways, which may be perturbed by environmental exposures, that are important in determining birth weight. Read More

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http://dx.doi.org/10.1021/acs.jproteome.7b00846DOI Listing
March 2018
36 Reads

Synergetic Effects of Prenatal and Postnatal High Sucrose Intake on Glucose Tolerance and Hepatic Insulin Resistance in Rat Offspring.

Mol Nutr Food Res 2018 03 19;62(5). Epub 2018 Feb 19.

Institute for Fetology, First Hospital of Soochow University, Suzhou, China.

Scope: High sucrose intake during pregnancy is linked to type 2 diabetes mellitus and altered insulin resistance.

Methods And Results: This study attempts to ascertain whether prenatal high sucrose intake (20% sucrose) alleviates the detrimental effects of high postnatal sugar consumption in the offspring, and the molecular mechanisms are investigated using a rat model. High prenatal sucrose exposure increases the body weight of the offspring at 1-3 weeks of age. Read More

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http://dx.doi.org/10.1002/mnfr.201700771DOI Listing
March 2018
9 Reads

Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health.

Environ Res 2018 02;161:505-511

Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan. Electronic address:

Bisphenol A and phthalates are widely detected in human urine, blood, breast milk, and amniotic fluid. Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics. Exposure to these chemicals during fetal development, and its consequences should be concerning because they can cross the placenta. Read More

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http://dx.doi.org/10.1016/j.envres.2017.11.052DOI Listing
February 2018
19 Reads

Metabolism and disposition of arsenic species from controlled oral dosing with sodium arsenite in adult female CD-1 mice. I. Pilot study to determine dosing, analytical measurements, and sampling strategies.

Food Chem Toxicol 2018 Jan 5;111:482-493. Epub 2017 Dec 5.

Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address:

Arsenic (As) is ubiquitous in the earth's crust, with typical dietary intake in developed countries <1 μg/kg bw/d, and atypical groundwater exposures in developing countries approaching 50 μg/kg bw/d. Arsenic exposures are linked with human diseases and doses of toxicological concern are similar to typical dietary intake estimates. The methylation of arsenite by arsenite-3-methyltransferase (As3MT) promotes the clearance of arsenic as pentavalent species, but also generates reactive trivalent intermediates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915173074
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http://dx.doi.org/10.1016/j.fct.2017.12.005DOI Listing
January 2018
11 Reads

Prenatal urinary polycyclic aromatic hydrocarbon metabolites, global DNA methylation in cord blood, and birth outcomes: A cohort study in China.

Environ Pollut 2018 Mar 1;234:396-405. Epub 2017 Dec 1.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is a potential risk factor for adverse birth outcomes. Epigenetic mechanisms may play a key role in which PAHs exert its effects.

Objective: Our study aimed to examine whether prenatal PAH exposure was associated with adverse birth outcomes and altered DNA methylation and to explore potential mediating roles of DNA methylation. Read More

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http://dx.doi.org/10.1016/j.envpol.2017.11.082DOI Listing
March 2018
9 Reads