1,404 results match your criteria Body Fluid Exposures


The influence of maternal and perinatal high-fat diet on ozone-induced pulmonary responses in offspring.

J Toxicol Environ Health A 2019 Feb 12:1-13. Epub 2019 Feb 12.

a Environmental Public Health Division , US Environmental Protection Agency , Durham , NC , USA.

There is growing interest in understanding how maternal diet might affect the sensitivity of offspring to environmental exposures. Previous studies demonstrated that adult rat offspring (approximately 6-months-old) from dams given a high-fat diet (HFD) prior to, during, and after pregnancy displayed elevated pulmonary responses to an acute ozone (O) exposure. The aim of this study was to examine the influence of maternal and perinatal HFD on pulmonary and metabolic responses to O in male and female young-adult offspring (approximately 3-month old). Read More

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http://dx.doi.org/10.1080/15287394.2018.1564101DOI Listing
February 2019

A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid and Plasma Concentrations of Cefepime.

mSphere 2019 01 30;4(1). Epub 2019 Jan 30.

Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA

This study sought to define the transit of cefepime between plasma and cerebral spinal fluid (CSF) in a rat model. Male Sprague-Dawley rats received cefepime intravenously. A total daily dose of 150 mg/kg of body weight/day was administered as a single injection every 24 h for 4 days. Read More

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http://dx.doi.org/10.1128/mSphere.00595-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354808PMC
January 2019

Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy.

Environ Health 2019 01 9;18(1). Epub 2019 Jan 9.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.

Background: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been reported to disrupt endocrine system and reproduction. However, epidemiological evidence on the association between PFAS and preeclampsia is inconsistent. We aimed to investigate the association between prenatal PFAS exposure and hypertensive disorders of pregnancy (HDP) in humans. Read More

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https://ehjournal.biomedcentral.com/articles/10.1186/s12940-
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http://dx.doi.org/10.1186/s12940-018-0445-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327470PMC
January 2019
6 Reads

Partitional calorimetry.

J Appl Physiol (1985) 2019 Feb 29;126(2):267-277. Epub 2018 Nov 29.

Thermal Ergonomics Laboratory, Faculty of Health Sciences, The University of Sydney , Sydney, NSW , Australia.

For thermal physiologists, calorimetry is an important methodological tool to assess human heat balance during heat or cold exposures. A whole body direct calorimeter remains the gold standard instrument for assessing human heat balance; however, this equipment is rarely available to most researchers. A more widely accessible substitute is partitional calorimetry, a method by which all components of the conceptual heat balance equation-metabolic heat production, conduction, radiation, convection, and evaporation-are calculated separately based on fundamental properties of energy exchange. Read More

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http://dx.doi.org/10.1152/japplphysiol.00191.2018DOI Listing
February 2019
1 Read

Metabolomics in the study of retinal health and disease.

Prog Retin Eye Res 2018 Nov 10. Epub 2018 Nov 10.

Retina Service, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, United States. Electronic address:

Metabolomics is the qualitative and quantitative assessment of the metabolites (small molecules < 1.5 kDa) in body fluids. The metabolites are the downstream of the genetic transcription and translation processes and also downstream of the interactions with environmental exposures; thus, they are thought to closely relate to the phenotype, especially for multifactorial diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13509462183002
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http://dx.doi.org/10.1016/j.preteyeres.2018.11.002DOI Listing
November 2018
12 Reads

Consideration of Occult Infection and Sepsis Mimics in the Sick Patient Without an Apparent Infectious Source.

J Emerg Med 2019 Jan 2;56(1):36-45. Epub 2018 Nov 2.

Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas.

Background: Evaluation and treatment of the acutely ill patient is typically complicated by multiple comorbidities and incomplete medical histories. This is exemplified by patients with sepsis, whose care is complicated by variable presentations, shifting definitions, and a variety of potential sources. Many practitioners fail to consider and recognize less-common sources of infection in a timely manner. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679183095
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http://dx.doi.org/10.1016/j.jemermed.2018.09.035DOI Listing
January 2019
7 Reads

The associations of workload, individual and organisational factors on nurses' occupational injuries.

J Clin Nurs 2019 Mar 8;28(5-6):902-911. Epub 2018 Nov 8.

Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran.

Aims And Objectives: To determine the prevalence and type of occupational injuries in nurses and their associations with workload, working shift, and nurses' individual and organisational factors.

Background: Nurses are vulnerable to occupational injuries due to the nature of their job.

Design: A cross-sectional correlational design (based on STROBE Statement) was conducted. Read More

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http://dx.doi.org/10.1111/jocn.14699DOI Listing
March 2019
16 Reads
1.233 Impact Factor

[Occupational and non occupational exposure to viral risk].

Rev Med Interne 2018 Oct 5. Epub 2018 Oct 5.

Service de médecine interne, hôpital Ambroise-Paré, HUPIFO, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne, France; UFR Paris Île-de-France Ouest, université Versailles Saint-Quentin-en-Yvelines, 78180 Versailles, France; GERES, UFR de médecine Bichat, 16, rue Henri-Huchart, 75018 Paris, France. Electronic address:

The transmission of an infectious disease can occur through exposure to blood or other potentially infectious body fluids, particularly in the event of skin-puncture injuries for healthcare workers, and during sexual intercourse. These situations are known as accidental blood exposures and sexual exposures respectively. Combined actions carried out have allowed to significantly reduce risks, either to healthcare professionals (by standard precautions, provision of safety devices, Hepatitis B vaccination made compulsory in the 1990s, antiretroviral post-exposure prophylaxis that should be initiated as soon as possible after exposure), or to people engaging in unprotected sex (by prevention messages, condom promotion, and antiretroviral post-exposure prophylaxis). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02488663183070
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http://dx.doi.org/10.1016/j.revmed.2018.09.002DOI Listing
October 2018
3 Reads

Genetic diversity, infection prevalence, and possible transmission routes of Bartonella spp. in vampire bats.

PLoS Negl Trop Dis 2018 09 27;12(9):e0006786. Epub 2018 Sep 27.

Odum School of Ecology, University of Georgia, Athens, Georgia, United States of America.

Bartonella spp. are globally distributed bacteria that cause endocarditis in humans and domestic animals. Recent work has suggested bats as zoonotic reservoirs of some human Bartonella infections; however, the ecological and spatiotemporal patterns of infection in bats remain largely unknown. Read More

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https://dx.plos.org/10.1371/journal.pntd.0006786
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http://dx.doi.org/10.1371/journal.pntd.0006786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159870PMC
September 2018
14 Reads

Assessment of adherence behaviors for the self-reporting of occupational exposure to blood and body fluids among registered nurses: A cross-sectional study.

PLoS One 2018 26;13(9):e0202069. Epub 2018 Sep 26.

Department of Burns Surgery, Xiangya Hospital of Central South University, Changsha City, Hu'nan Province, China.

Background: In China, register nurses (RNs) have a high risk of occupational exposure to blood/body fluids. The adherence behavior related to self-reporting of occupational exposure needs to be evaluated to protect RNs from healthcare-related infections.

Objectives: To assess adherence behaviors for self-reporting of occupational exposure to blood and body fluids among RNs and identify factors affecting self-reporting in Hunan Province, China for developing upgraded strategies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202069PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157846PMC
February 2019
11 Reads

Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes.

Environ Pollut 2018 Dec 19;243(Pt B):1126-1133. Epub 2018 Sep 19.

Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, AState Key Laboratory of Environmental Health (incubating), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Prenatal disinfection by-products (DBPs) exposure is linked with adverse birth outcomes. Genetic susceptibility to DBP metabolism may modify the exposure-outcome associations.

Object: To investigate whether CYP2E1 and GSTZ1 genetic polymorphisms modified the associations of prenatal DBP exposures with adverse birth outcomes. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.09.083DOI Listing
December 2018
2 Reads

Identification and quantification of spinochromes in body compartments of 's coloured types.

R Soc Open Sci 2018 Aug 22;5(8):171213. Epub 2018 Aug 22.

Biology of Marine Organisms and Biomimetics Unit, Research Institute for Biosciences, University of Mons-UMONS, 23 Place du Parc, 7000 Mons, Belgium.

Sea urchin pigmentation is mainly due to polyhydroxy-1,4-naphthoquinones called spinochromes. If their molecular structures are well known in test and spines of many species, their abundance and distribution in other body compartments remain unstudied. The aim of this study is to analyse the pigment composition in four body compartments (test/spines, digestive system, gonads and coelomic fluid) of four coloured types of the sea urchin . Read More

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http://dx.doi.org/10.1098/rsos.171213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124065PMC
August 2018
12 Reads

Ambient air pollution, H19/DMR methylation in cord blood and newborn size: A pilot study in Zhengzhou City, China.

Chemosphere 2018 Dec 30;212:863-871. Epub 2018 Aug 30.

Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address:

Prenatal exposure to air pollutants is believed to be associated with adverse birth outcomes. However, the potential mechanisms, especially the epigenetic modified effects, still remain unclear. This study was designed to explore the association of air pollution, H19/DMR methylation levels, and birth weight and length. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.08.140DOI Listing
December 2018
9 Reads
3.340 Impact Factor

Mind the weather: a report on inter-annual variations in entomological data within a rural community under insecticide-treated wall lining installation in Kwara State, Nigeria.

Parasit Vectors 2018 Sep 4;11(1):497. Epub 2018 Sep 4.

Molecular Entomology and Vector Control Research Laboratory, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.

Background: Entomological indices within a specific area vary with climatic factors such as rainfall, temperature and relative humidity. Contributions of such weather parameter fluctuations to the changes in entomological data obtained within a community under implementation of a promising vector control intervention should be taken into account. This study reports on inter-annual changes in entomological indices within two rural communities, one of which was under insecticide-treated durable wall lining (DL) installation. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3078-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123909PMC
September 2018
11 Reads

Trend analysis and factors associated with biological injuries among health care workers in Southern Italy.

Med Lav 2018 Aug 28;109(4):308-315. Epub 2018 Aug 28.

University of L'Aquila.

Background: Biological injuries are the most common and serious among health care workers.

Objectives: This study aims to estimate the injuries' incidence, job distribution and temporal trend in a hospital in Southern Italy.

Methods: Data on accidents, collected from January 2010 to December 2016, were analyzed. Read More

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http://dx.doi.org/10.23749/mdl.v109i4.7245DOI Listing
August 2018
12 Reads

Global metabolomic responses in urine from atm deficient mice in response to LD gamma irradiation doses.

Environ Mol Mutagen 2018 08 10;59(7):576-585. Epub 2018 Aug 10.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia.

Exposures to ionizing radiation (IR) may either be accidental or intentional, for medical purposes or even through terrorist actions. As certain populations emerge to be more radiosensitive than others, it is imperative to assess those individuals and treat them accordingly. To demonstrate the feasibility of rapid identification of such cases, we utilized the highly radiosensitive mouse model Atm in the C57BL/6 background, and evaluated the urinary responses in 8-10 week old male mice at early time points (4, 24, and 72 h) after exposure to their respective LD doses [4 Gy for Atm , and 8 Gy for wild type (WT)]. Read More

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http://dx.doi.org/10.1002/em.22202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113093PMC
August 2018
3 Reads

Lead exposure biomarkers in the Common Loon.

Sci Total Environ 2019 Jan 4;647:639-644. Epub 2018 Aug 4.

Cummings School of Veterinary Medicine, Tufts University, N. Grafton, MA, United States of America.

Lead in fishing tackle is a significant source of exposure to the environment, wildlife, and potentially humans. Common Loons (Gavia immer) are exposed to lead by eating fish which have lead tackle, or ingesting fishing weights or spent ammunition when they ingest small stones to aid in digestion. Blood lead is traditionally used as a biomarker of exposure in loons, but it only reflects recent exposures. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.08.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168339PMC
January 2019
3 Reads

Epidemiological Characteristics of the Accidental Exposures to Blood-Borne Pathogens Among Workers in the Hospital.

Med Arch 2018 Jun;72(3):187-191

Clinic for Cardiovascular surgery, University Clinical Center Tuzla, Bosnia and Herzegovina.

Introduction: The main route of acquiring infectious blood and body fluids in hospital conditions is accidental exposure to stinging incidents.

Aim: The aim of this study was to determine the epidemiological characteristics of accidental exposures to blood-borne pathogens among different professional groups of health care workers (HCWs).

Materials And Methods: A cross-sectional study was conducted using the "Questionnaire on the HCWs exposure to blood and blood transmitted infections" at the University Clinical Centre Tuzla, Bosnia and Herzegovina, from the 1st of March to the 31st of December 2014. Read More

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http://dx.doi.org/10.5455/medarh.2018.72.187-191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021162PMC
June 2018
4 Reads

Dynamic Characteristics of Sequential Acute Exacerbations and Risk Windows in AECOPD Rats Induced by Cigarette-Smoke and Exposure to Klebsiella pneumoniae.

Biol Pharm Bull 2018 Oct 28;41(10):1543-1553. Epub 2018 Jul 28.

Collaborative Innovation Center for Respiratory Diseases Diagnostics, Treatment and New Drug Research and Development of Henan University of Traditional Chinese Medicine (TCM).

The risk-window (RW) of chronic obstructive pulmonary disease (COPD) is a period after an acute exacerbation (AE) but before the following stable phase, in which exacerbations are easy to relapse. We established a sequential COPD-AE-RW rat model by cigarette-smoke and bacterial exposures in the first 8 weeks, and was challenged with Klebsiella pneumonia to mimic an AE on Day 1 of week 9, and found that body temperature, white blood cell, neutrophils, serum amyloid A (SAA) and C-reactive protein (CRP) increased in AECOPD rats 24 h after challenge, and declined in 3-6 d, while lung function declined in 48 h, and recovered in 7-16 d. When sacrificed, pulmonary forced expiratory volume (FEV)100 and FEV300 decreased, while elevated bronchoalveolar lavage fluid (BALF) neutrophils and marked airway inflammation, remodeling and emphysema were observed. Read More

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https://www.jstage.jst.go.jp/article/bpb/41/10/41_b18-00148/
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http://dx.doi.org/10.1248/bpb.b18-00148DOI Listing
October 2018
2 Reads

[Survey of Anticancer Drug Exposure to Attendant Families in Pediatric Medical Centers].

Gan To Kagaku Ryoho 2018 Jun;45(6):945-948

Medical Center for Child Health, Dept. of Nursing, Kyushu University Hospital.

The occupational exposure to hazardous drugs(HD)has already been investigated; however, the actual exposure of the attendant family members of patients with childhood cancer has remained unknown. Here, we analyzed cyclophosphamide (CPM)exposure in attendant family members and the environment after the administration of CPM to patients with pediatric cancer. CPM of 320(8. Read More

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June 2018
1 Read

Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques.

J Virol 2018 09 16;92(17). Epub 2018 Aug 16.

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Current approaches do not eliminate all human immunodeficiency virus type 1 (HIV-1) maternal-to-infant transmissions (MTIT); new prevention paradigms might help avert new infections. We administered maraviroc (MVC) to rhesus macaques (RMs) to block CCR5-mediated entry, followed by repeated oral exposure of a CCR5-dependent clone of simian immunodeficiency virus (SIV) mac251 (SIVmac766). MVC significantly blocked the CCR5 coreceptor in peripheral blood mononuclear cells and tissue cells. Read More

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http://dx.doi.org/10.1128/JVI.00576-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096825PMC
September 2018
7 Reads

Maternal and cord blood manganese (Mn) levels and birth weight: The MIREC birth cohort study.

Int J Hyg Environ Health 2018 07 7;221(6):876-882. Epub 2018 Jun 7.

Department of Environmental and Occupational Health, University of Montreal, Montreal, QC, H3C 3J7, Canada. Electronic address:

Epidemiological studies have hypothesized that both insufficient and excess blood manganese (Mn) levels during pregnancy are associated with reduced fetal growth. This literature is characterized by inconsistent results and a limited focus on women with exposures representative of the general North American population. We examined the relationship between maternal and cord blood Mn levels and fetal growth among women enrolled in the Maternal-Infant Research on Environmental Chemicals Study (MIREC). Read More

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http://dx.doi.org/10.1016/j.ijheh.2018.05.015DOI Listing
July 2018
2 Reads

Recipes for simulated vomitus.

J Infect Prev 2018 May 20;19(3):141-143. Epub 2017 Nov 20.

School of Public Health, University of Illinois at Chicago, USA.

We developed and demonstrated the stability of recipes for simulated vomitus for use in experiments characterizing occupational exposures to body fluid during simulated healthcare activities. The recipes can be easily adapted to make other simulated bodily fluids at low costs and surrogates added to facilitate detection. Read More

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http://dx.doi.org/10.1177/1757177417741972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956701PMC

Experimental challenges regarding the in vitro investigation of the nanoparticle-biocorona in disease states.

Toxicol In Vitro 2018 Sep 5;51:40-49. Epub 2018 May 5.

School of Health Sciences, Purdue University, 550 Stadium Mall Dr, West Lafayette, IN 47907, United States. Electronic address:

Toxicological evaluation of nanoparticles (NPs) requires the utilization of in vitro techniques due to their number and diverse properties. Cell culture systems are often lacking in their ability to perform comparative toxicity assessment due to dosimetry issues and capacity to simulate in vivo environments. Upon encountering a physiological environment, NPs become coated with biomolecules forming a biocorona (BC), influencing function, biodistribution, and toxicity. Read More

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http://dx.doi.org/10.1016/j.tiv.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291017PMC
September 2018
1 Read

Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data.

Dev Cogn Neurosci 2018 Aug 16;32:97-106. Epub 2018 Mar 16.

Department of Pediatrics, Keck School of Medicine, University of Southern California, and Children's Hospital Los Angeles, Los Angeles, CA, USA. Electronic address:

Biospecimen collection in the Adolescent Brain Cognitive Development (ABCD) study - of hair samples, shed deciduous (baby) teeth, and body fluids - will serve dual functions of screening for study eligibility, and providing measures of biological processes thought to predict or correlate with key study outcomes on brain and cognitive development. Biosamples are being collected annually to screen for recency of drug use prior to the neuroimaging or cognitive testing visit, and to store for the following future studies: (1) on the effects of exposure to illicit and recreational drugs (including alcohol and nicotine); (2) of pubertal hormones on brain and cognitive developmental trajectories; (3) on the contribution of genomics and epigenomics to child and adolescent development and behavioral outcomes; and (4) with pre- and post-natal exposure to environmental neurotoxicants and drugs of abuse measured from novel tooth analyses. The present manuscript describes the rationales for inclusion and selection of the specific biospecimens, methodological considerations for each measure, future plans for assessment of biospecimens during follow-up visits, and preliminary ABCD data to illustrate methodological considerations. Read More

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http://dx.doi.org/10.1016/j.dcn.2018.03.005DOI Listing
August 2018
10 Reads

Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort.

Epigenetics 2018 16;13(3):290-300. Epub 2018 May 16.

a Division of Environmental Genetics and Molecular Toxicology.

Faroe islanders consume marine foods contaminated with methylmercury (MeHg), polychlorinated biphenyls (PCBs), and other toxicants associated with chronic disease risks. Differential DNA methylation at specific CpG sites in cord blood may serve as a surrogate biomarker of health impacts from chemical exposures. We aimed to identify key environmental chemicals in cord blood associated with DNA methylation changes in a population with elevated exposure to chemical mixtures. Read More

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http://dx.doi.org/10.1080/15592294.2018.1445901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997167PMC
February 2019
1 Read

Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.

Mult Scler 2018 Mar 1:1352458518763541. Epub 2018 Mar 1.

Department of Neurology and Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Background: The course of multiple sclerosis (MS) shows substantial inter-individual variability. The underlying determinants of disease severity likely involve genetic and environmental factors.

Objective: The aim of this study was to assess the impact of APOE and HLA polymorphisms as well as smoking and body mass index (BMI) in the very early MS course. Read More

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http://journals.sagepub.com/doi/10.1177/1352458518763541
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http://dx.doi.org/10.1177/1352458518763541DOI Listing
March 2018
19 Reads

Maternal levels of endocrine disrupting chemicals in the first trimester of pregnancy are associated with infant cord blood DNA methylation.

Epigenetics 2018 18;13(3):301-309. Epub 2018 Apr 18.

a Department of Environmental Health Sciences, School of Public Health , University of Michigan , Ann Arbor , MI , USA.

Endocrine disrupting chemicals (EDCs) pose a public health risk through disruption of normal biological processes. Identifying toxicoepigenetic mechanisms of developmental exposure-induced effects for EDCs, such as phthalates or bisphenol A (BPA), is essential. Here, we investigate whether maternal exposure to EDCs is predictive of infant DNA methylation at candidate gene regions. Read More

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https://www.tandfonline.com/doi/full/10.1080/15592294.2018.1
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http://dx.doi.org/10.1080/15592294.2018.1448680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997152PMC
February 2019
1 Read

Neonatal intensive care unit phthalate exposure and preterm infant neurobehavioral performance.

PLoS One 2018 5;13(3):e0193835. Epub 2018 Mar 5.

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Every year in the United States, more than 300,000 infants are admitted to neonatal intensive care units (NICU) where they are exposed to a chemical-intensive hospital environment during a developmentally vulnerable period. The neurodevelopmental impact of environmental exposure to phthalates during the NICU stay is unknown. As phthalate exposure during the third trimester developmental window has been implicated in neurobehavioral deficits in term-born children that are strikingly similar to a phenotype of neurobehavioral morbidity common among children born premature, the role of early-life phthalate exposure on the neurodevelopmental trajectory of premature infants may be clinically important. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193835PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837295PMC
June 2018
6 Reads

Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation.

Epigenetics 2018 16;13(1):108-116. Epub 2018 Feb 16.

a Department of Epidemiology, School of Public Health , University of Michigan.

Cord blood DNA methylation is associated with numerous health outcomes and environmental exposures. Whole cord blood DNA reflects all nucleated blood cell types, while centrifuging whole blood separates red blood cells, generating a white blood cell buffy coat. Both sample types are used in DNA methylation studies. Read More

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http://dx.doi.org/10.1080/15592294.2017.1417710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836975PMC
December 2018
3 Reads

Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine.

Gut 2018 06 6;67(6):1168-1180. Epub 2018 Feb 6.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Immunotherapy strategies targeting immune checkpoints such as the and (programmed cell death 1 ligand 1, PD-L1)/ (programmed cell death 1, PD-1) T-cell coreceptor pathways are revolutionising oncology. The approval of pembrolizumab use for solid tumours with high-level microsatellite instability or mismatch repair deficiency by the US Food and Drug Administration highlights promise of precision immuno-oncology. However, despite evidence indicating influences of exogenous and endogenous factors such as diet, nutrients, alcohol, smoking, obesity, lifestyle, environmental exposures and microbiome on tumour-immune interactions, integrative analyses of those factors and immunity lag behind. Read More

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http://dx.doi.org/10.1136/gutjnl-2017-315537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943183PMC
June 2018
7 Reads

Maternal depression, antidepressant use and placental oxytocin receptor DNA methylation: Findings from the MPEWS study.

Psychoneuroendocrinology 2018 04 4;90:1-8. Epub 2018 Jan 4.

School of Psychology and Exercise Science, Murdoch University, Australia.

The aim of this study was to investigate placental DNA methylation of the oxytocin receptor gene (OXTR) in women with depression in pregnancy. We also explored the role of antidepressant medication in pregnancy on placental OXTR methylation. Data were obtained from 239 women in the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS), a selected pregnancy cohort. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2018.01.004DOI Listing
April 2018
10 Reads
4.944 Impact Factor

Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study.

J Proteome Res 2018 03 9;17(3):1235-1247. Epub 2018 Feb 9.

MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London , St. Mary's Campus, Norfolk Place, London W2 1PG, United Kingdom.

Birth weight is an important indicator of maternal and fetal health and a predictor of health in later life. However, the determinants of variance in birth weight are still poorly understood. We aimed to identify the biological pathways, which may be perturbed by environmental exposures, that are important in determining birth weight. Read More

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http://dx.doi.org/10.1021/acs.jproteome.7b00846DOI Listing
March 2018
20 Reads

Synergetic Effects of Prenatal and Postnatal High Sucrose Intake on Glucose Tolerance and Hepatic Insulin Resistance in Rat Offspring.

Mol Nutr Food Res 2018 03 19;62(5). Epub 2018 Feb 19.

Institute for Fetology, First Hospital of Soochow University, Suzhou, China.

Scope: High sucrose intake during pregnancy is linked to type 2 diabetes mellitus and altered insulin resistance.

Methods And Results: This study attempts to ascertain whether prenatal high sucrose intake (20% sucrose) alleviates the detrimental effects of high postnatal sugar consumption in the offspring, and the molecular mechanisms are investigated using a rat model. High prenatal sucrose exposure increases the body weight of the offspring at 1-3 weeks of age. Read More

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http://dx.doi.org/10.1002/mnfr.201700771DOI Listing
March 2018
4 Reads

Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health.

Environ Res 2018 02;161:505-511

Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan. Electronic address:

Bisphenol A and phthalates are widely detected in human urine, blood, breast milk, and amniotic fluid. Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics. Exposure to these chemicals during fetal development, and its consequences should be concerning because they can cross the placenta. Read More

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http://dx.doi.org/10.1016/j.envres.2017.11.052DOI Listing
February 2018
15 Reads

Metabolism and disposition of arsenic species from controlled oral dosing with sodium arsenite in adult female CD-1 mice. I. Pilot study to determine dosing, analytical measurements, and sampling strategies.

Food Chem Toxicol 2018 Jan 5;111:482-493. Epub 2017 Dec 5.

Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address:

Arsenic (As) is ubiquitous in the earth's crust, with typical dietary intake in developed countries <1 μg/kg bw/d, and atypical groundwater exposures in developing countries approaching 50 μg/kg bw/d. Arsenic exposures are linked with human diseases and doses of toxicological concern are similar to typical dietary intake estimates. The methylation of arsenite by arsenite-3-methyltransferase (As3MT) promotes the clearance of arsenic as pentavalent species, but also generates reactive trivalent intermediates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915173074
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http://dx.doi.org/10.1016/j.fct.2017.12.005DOI Listing
January 2018
11 Reads

Prenatal urinary polycyclic aromatic hydrocarbon metabolites, global DNA methylation in cord blood, and birth outcomes: A cohort study in China.

Environ Pollut 2018 Mar 1;234:396-405. Epub 2017 Dec 1.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is a potential risk factor for adverse birth outcomes. Epigenetic mechanisms may play a key role in which PAHs exert its effects.

Objective: Our study aimed to examine whether prenatal PAH exposure was associated with adverse birth outcomes and altered DNA methylation and to explore potential mediating roles of DNA methylation. Read More

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http://dx.doi.org/10.1016/j.envpol.2017.11.082DOI Listing
March 2018
8 Reads

Health-care workers' occupational exposures to body fluids in 21 countries in Africa: systematic review and meta-analysis.

Bull World Health Organ 2017 Dec 13;95(12):831-841F. Epub 2017 Oct 13.

Department of Demography and Social Statistics, Covenant University, Ota, Nigeria.

Objective: To estimate the lifetime and 12-month prevalence of occupational exposure to body fluids among health-care workers in Africa.

Methods: Embase®, PubMed® and CINAHL databases were systematically searched for studies published between January 2000 and August 2017 that reported the prevalence of occupational exposure to blood or other body fluids among health-care workers in Africa. The continent-wide prevalence of exposure was estimated using random-effects meta-analysis. Read More

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http://dx.doi.org/10.2471/BLT.17.195735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710084PMC
December 2017
18 Reads
1 Citation
5.090 Impact Factor

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury.

Int J Circumpolar Health 2017 ;76(1):1406234

a Department of Environmental Medicine , University of Southern Denmark , Odense C , Denmark.

This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother-child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Read More

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http://dx.doi.org/10.1080/22423982.2017.1406234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717715PMC
August 2018
1 Read

Regional differences of cFos immunoreactive cells in the preoptic areas in hypothalamus associated with heat and cold responses in mice.

Neurosci Lett 2018 02 26;665:130-134. Epub 2017 Nov 26.

Body Temperature and Fluid Laboratory, Faculty of Human Sciences, Waseda University, Saitama, Japan; Institute of Applied Brain Sciences, Waseda University, Saitama, Japan. Electronic address:

cFos expression in the preoptic area (PO), which is thermoregulatory center increased by both heat and cold exposures; however, the regional difference is unknown yet. We aimed to determine if cFos expression in the PO was regionally different between heat and cold exposures. Mice were exposed to 27, 10, or 38°C for 90min, and body temperature (T) was measured. Read More

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http://dx.doi.org/10.1016/j.neulet.2017.11.053DOI Listing
February 2018
2 Reads

Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother-neonate pairs.

Sci Total Environ 2018 Jun 13;626:1494-1501. Epub 2017 Nov 13.

Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. Electronic address:

Bisphenol A (BPA) exposure during the perinatal and postnatal periods increases the susceptibility to disease over the life cycle. However, information on the BPA delivered to fetuses or infants via the placenta and breastfeeding is limited. We determined the BPA exposure levels in various bodily fluids and tissues of pregnant women and described fetus and infant exposures to BPA based on associations and BPA ratios in mother-neonate paired samples. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2017.10.042DOI Listing
June 2018
34 Reads

Association Between Prepregnancy Body Mass Index and Severe Maternal Morbidity.

JAMA 2017 11;318(18):1777-1786

Department of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver, Canada.

Importance: Although high body mass index (BMI) is associated with adverse birth outcomes, the association with severe maternal morbidity is unclear.

Objective: To examine the association between prepregnancy BMI and severe maternal morbidity.

Design, Setting, And Participants: Retrospective population-based cohort study including all singleton hospital births in Washington State, 2004-2013. Read More

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http://dx.doi.org/10.1001/jama.2017.16191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820710PMC
November 2017
6 Reads

Prenatal traffic-related air pollution exposures, cord blood adipokines and infant weight.

Pediatr Obes 2018 06 3;13(6):348-356. Epub 2017 Nov 3.

Department of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, USA.

Objective: Studies suggest that prenatal exposure to traffic-related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early-life weight gain.

Methods: The Maternal and Child Health Study birth cohort included 136 women from the Los Angeles County + University of Southern California Medical Center. Read More

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http://dx.doi.org/10.1111/ijpo.12248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934325PMC
June 2018
1 Read

Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging.

JAMA Pediatr 2017 12;171(12):1160-1167

Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.

Importance: Telomere length is a marker of biological aging that may provide a cellular memory of exposures to oxidative stress and inflammation. Telomere length at birth has been related to life expectancy. An association between prenatal air pollution exposure and telomere length at birth could provide new insights in the environmental influence on molecular longevity. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2017.3024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233867PMC
December 2017
11 Reads

Acute and Chronic Kidney Injury in a Non-Human Primate Model of Partial-Body Irradiation with Bone Marrow Sparing.

Radiat Res 2017 12 16;188(6):661-671. Epub 2017 Oct 16.

b   Radiation Oncology, University of Maryland, School of Medicine, Baltimore, Maryland; and.

The development of medical countermeasures against acute and delayed multi-organ injury requires animal models predictive of the human response to radiation and its treatment. Late chronic injury is a well-known feature of radiation nephropathy, but acute kidney injury has not been reported in an appropriate animal model. We have established a single-fraction partial-body irradiation model with minimal marrow sparing in non-human primates. Read More

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http://dx.doi.org/10.1667/RR24857.1DOI Listing
December 2017
13 Reads
2.911 Impact Factor

Suspect screening of maternal serum to identify new environmental chemical biomonitoring targets using liquid chromatography-quadrupole time-of-flight mass spectrometry.

J Expo Sci Environ Epidemiol 2018 03 11;28(2):101-108. Epub 2017 Oct 11.

Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA.

The use and advantages of high-resolution mass spectrometry (MS) as a discovery tool for environmental chemical monitoring has been demonstrated for environmental samples but not for biological samples. We developed a method using liquid chromatography-quadrupole time-of-flight MS (LC-QTOF/MS) for discovery of previously unmeasured environmental chemicals in human serum. Using non-targeted data acquisition (full scan MS analysis) we were able to screen for environmental organic acids (EOAs) in 20 serum samples from second trimester pregnant women. Read More

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http://dx.doi.org/10.1038/jes.2017.28DOI Listing
March 2018
28 Reads
1 Citation
3.190 Impact Factor

Characterisation of occupational blood and body fluid exposures beyond the Needlestick Safety and Prevention Act.

J Infect Prev 2016 Sep 27;17(5):226-232. Epub 2016 Apr 27.

Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Objective: To describe the use of mandated safety engineered sharps devices (SESDs) and personal protective equipment in healthcare workers (HCWs) with occupational body fluid exposures (BFE) since the Needlestick Safety and Prevention Act.

Methods: Two questionnaires were administered, over 3 years, to HCWs who reported sharps or splash BFEs. Descriptive statistics and chi-square analysis were used. Read More

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http://dx.doi.org/10.1177/1757177416645339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102074PMC
September 2016
5 Reads

Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model.

PLoS Negl Trop Dis 2017 Sep 21;11(9):e0005942. Epub 2017 Sep 21.

Merck Global Health Institute, Ares Trading S.A., a subsidiary of Merck KGaA (Darmstadt, Germany), Coinsins, Switzerland.

After more than 40 years of use, Praziquantel (PZQ) still remains the drug of choice for the treatment of intestinal and urogenital schistosomiasis. Its anti-parasitic activity resides primarily in the (R)-enantiomer. Hitherto neither the molecular target nor the pharmacokinetic-pharmacodynamic relationship have been fully elucidated. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626502PMC
September 2017
28 Reads