1,371,962 results match your criteria Body & Society[Journal]


Acot9 traffics mitochondrial short-chain fatty acids towards de novo lipogenesis and glucose production in the liver.

Hepatology 2020 Jun 4. Epub 2020 Jun 4.

Joan & Sanford I, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Obesity-induced pathogenesis of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) is associated with increased de novo lipogenesis (DNL) and hepatic glucose production (HGP) due to excess fatty acids. Acyl-CoA thioesterase (Acot) family members control the cellular utilization of fatty acids by hydrolyzing (deactivating) acyl-CoA into non-esterified fatty acids and CoASH. Using C. Read More

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http://dx.doi.org/10.1002/hep.31409DOI Listing

What is the pattern of the neuropathy associated with anti-FGFR3 antibodies?

Eur J Neurol 2020 Jun 4. Epub 2020 Jun 4.

Synaptopathies and Autoantibodies, Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, University of Lyon, University Jean-Monnet, Saint-Étienne, France.

A growing body of evidence is demonstrating the interest of anti-FGFR3 antibodies for the diagnosis of inflammatory neuropathies in patients with no other indication that their neurological disorder may be immune mediated. An important issue is to characterize the pattern of the neuropathy with anti-FGFR3 antibodies. In our initial study, we only detected high titer of anti-FGFR3 antibodies in patients with purely sensory disorders mostly fulfilling the criteria of sensory neuronopathy [1]. Read More

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http://dx.doi.org/10.1111/ene.14376DOI Listing

Highly sensitive wearable flexible strain sensor based on poly-crystalline MoS2 thin film.

Nanotechnology 2020 Jun 4. Epub 2020 Jun 4.

Centre for Applied Research in Electronics (CARE), Indian Institute of Technology Delhi, New Delhi, 110016, INDIA.

The present study investigates the piezoresistive property of poly-crystalline MoS2 film for strain sensing applications. The gauge factor (GF) of flexible MoS2 device (MoS2/PET) has been calculated to be 102±5 in the stress ranging from ~7 MPa to ~14 MPa. In addition, to improve the sensing stress range, the flexible strain sensors are encapsulated by SU-8. Read More

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http://dx.doi.org/10.1088/1361-6528/ab9970DOI Listing

Noncoplanar ferrimagnetism and local crystalline-electric-field anisotropy in the quasicrystal approximant Au70Si17Tb13.

J Phys Condens Matter 2020 Jun 4. Epub 2020 Jun 4.

Dept. Materials Science & Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, Tokyo, Tokyo, 125-8585, JAPAN.

Neutron scattering experiments have been performed to elucidate magnetic properties of the qua- sicrystal approximant Au70Si17Tb13, consisting of icosahedral spin clusters in a body-centered-cubic lattice. Bulk magnetic measurements performed on the single crystalline sample unambiguously confirm long-range ordering at TC = 11.6 ± 1 K. Read More

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http://dx.doi.org/10.1088/1361-648X/ab997dDOI Listing

Reducing Sitting Time in Obese Older Adults: The I-STAND Randomized Controlled Trial.

J Aging Phys Act 2020 Jun 4:1-11. Epub 2020 Jun 4.

Background: The authors tested the efficacy of the "I-STAND" intervention for reducing sitting time, a novel and potentially health-promoting approach, in older adults with obesity.

Methods: The authors recruited 60 people (mean age = 68 ± 4.9 years, 68% female, 86% White; mean body mass index = 35. Read More

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http://dx.doi.org/10.1123/japa.2019-0470DOI Listing

Pregnancy outcomes and postpartum relapse rates in women with RRMS treated with alemtuzumab in the phase 2 and 3 clinical development program over 16 years.

Mult Scler Relat Disord 2020 May 6;43:102146. Epub 2020 May 6.

University of Cambridge, Cambridge, United Kingdom. Electronic address:

Background: Relapsing-remitting multiple sclerosis (RRMS) is frequently diagnosed in women of reproductive age. Because the use of disease-modifying therapies (DMTs) early in the disease course is increasing, it is important to evaluate the safety of DMTs in pregnant women and their developing fetuses. Alemtuzumab, approved for the treatment of relapsing forms of MS, is administered as 2 courses of 12 mg/day on 5 consecutive days at baseline and on 3 consecutive days 12 months later. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102146DOI Listing

Bone health in neuromyelitis optica: Bone mineral density and fractures.

Mult Scler Relat Disord 2020 Apr 28;42:102080. Epub 2020 Apr 28.

Department of Neurology, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea; Department of Neurology, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: The bone health in neuromyelitis optica spectrum disorder with aquaporin-4 immunoglobulin G antibodies (NMOSD-AQP4) have not been fully evaluated. To evaluate the prevalence of fractures and bone loss in patients with NMOSD-AQP4 compared to healthy controls and patients with multiple sclerosis (MS) and to identify the risk factors associated with fractures and low bone mineral density (BMD) in patients with NMOSD-AQP4.

Methods: Seventy-one patients with NMOSD-AQP4 were included. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102080DOI Listing

Validation of different stepping counters during treadmill and over ground walking.

Gait Posture 2020 May 29;80:80-83. Epub 2020 May 29.

Sport sciences, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, DK-9220 Aalborg East, Denmark.

Background: Commercially available physical activity trackers are very popular in the general population and are increasingly common in clinical and research settings. The marketfor activity trackers are rapidly expanding, requiring them to be validated on an ongoing basis. Different approaches have been used for validating these devices. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.037DOI Listing

Blood glucose monitoring- an overview of current and future non-invasive devices.

Diabetes Metab Syndr 2020 May 22;14(5):739-751. Epub 2020 May 22.

Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, USA. Electronic address:

Background And Aims: Blood glucose monitoring is very important for individuals with diabetes due to its rate determining role in medication strength adjustment and observation of possible life-threatening hypoglycemia. Possible non-invasive devices can overcome some of these burdens and could increase adherence towards checking blood glucose.

Methods: Data extraction methods were primarily based through various PubMed scholarly articles for real-world examples of non-invasive approaches. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.05.016DOI Listing

Influence of type 1 diabetes on the postural control of women in the third gestational trimester.

Clin Biomech (Bristol, Avon) 2020 May 28;77:105062. Epub 2020 May 28.

Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Ribeirão Preto, São Paulo CEP: 14049-900, Brazil. Electronic address:

Background: Diabetes can cause biomechanical alterations that may be responsible for additional changes to those existing in a regular gestational period. The way a maternal body responds when affected by diabetes has not been clearly understood. This study aimed to describe the influence of type 1 diabetes on pregnant women's postural control. Read More

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http://dx.doi.org/10.1016/j.clinbiomech.2020.105062DOI Listing

Ultrathin hetero-nanosheets assembled hollow Ni-Co-P/C for hybrid supercapacitors with enhanced rate capability and cyclic stability.

J Colloid Interface Sci 2020 May 25;577:368-378. Epub 2020 May 25.

State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, PR China.

Nanohybrid-type Ni-Co-phosphide/C (Ni-Co-P/C) hollow microflowers with ultrathin nanosheets (HUNs) are constructed through a modified ethylene glycol-mediated self-assembly process and further phosphating treatment. The peculiar structure can availably provide affluent mass transfer channels and active sites, meanwhile inhibit the aggregation of nanosheets. The synergistic effects of the produced Ni-Co-P/C are demonstrated systematically through regulating the initial Ni/Co ratio. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.05.065DOI Listing

Exposure to light at night (LAN) and risk of obesity: A systematic review and meta-analysis of observational studies.

Environ Res 2020 May 12;187:109637. Epub 2020 May 12.

Healthy High Density Cities Lab, HKUrbanLab, The University of Hong Kong, Knowles Building, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China.

Background: There is emerging evidence of the association between light at night (LAN) exposure and weight gain.

Objective: We aim to conduct a systematic review and meta-analysis of observational studies on the association between LAN exposure and risk of obesity in human subjects.

Methods: Peer-reviewed observational studies were systematically searched from MEDLINE (EBSCO), Academic Search Complete (EBSCO), CINAHL Plus (EBSCO) and PubMed up to December 24, 2019. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109637DOI Listing

Inferior vena cava stenosis-induced deep vein thrombosis is influenced by multiple factors in rats.

Biomed Pharmacother 2020 Jun 1;128:110270. Epub 2020 Jun 1.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address:

Background: The pathogenesis of deep vein thrombosis (DVT) is incompletely understood, requiring reliable animal models. Inferior vena cava (IVC) stenosis model mimics human DVT.

Objective: To provide optimal conditions for establishing a rat model of IVC stenosis-induced DVT. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110270DOI Listing

Maternal and embryonic trace element concentrations and stable isotope fractionation in the smalleye smooth-hound (Mustelus higmani).

Chemosphere 2020 May 27;257:127183. Epub 2020 May 27.

Núcleo de Ecologia Aquática e Pesca da Amazônia, Universidade Federal Do Pará, Belém, PA, Brazil.

Here, we evaluate maternal offloading of 16 trace elements (Essential: Co, Cr, Cu, Fe, Mn, Ni, Se and Zn; Nonessential: Al, As, Ba, Cd, Hg, Pb, Tl and U) and determine mother-offspring isotopic fractionation of δC and δN in muscle and liver tissue of four pregnant Mustelus higmani and 18 associated embryos sampled from the Amazon Coast of Brazil. Embryo muscle tissue had significantly higher concentrations of most trace elements when compared to mothers, with the exception of Hg. Embryo liver accumulated more nonessential elements than muscle (n = 7 vs. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127183DOI Listing

Ammonia exposure impairs lateral-line hair cells and mechanotransduction in zebrafish embryos.

Chemosphere 2020 May 27;257:127170. Epub 2020 May 27.

Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address:

Ammonia (including NH and NH) is a major pollutant of freshwater environments. However, the toxic effects of ammonia on the early stages of fish are not fully understood, and little is known about the effects on the sensory system. In this study, we hypothesized that ammonia exposure can cause adverse effects on embryonic development and impair the lateral line system of fish. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127170DOI Listing

Prevalence and correlates of normal body mass index central obesity among people with cardiovascular diseases in Australia.

Public Health 2020 Jun 1;183:126-131. Epub 2020 Jun 1.

Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia; Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia. Electronic address:

Objective: Obesity is one of the most common risk factors for cardiometabolic diseases in Australia and worldwide. Recent studies show that people with normal body mass index (BMI) but with central obesity are at increased risk of morbidity and mortality from cardiometabolic diseases. This risk has not been explained well. Read More

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http://dx.doi.org/10.1016/j.puhe.2020.03.013DOI Listing

Ethnic Disparities in Hospitalisation for COVID-19 in England: The Role of Socioeconomic Factors, Mental Health, and Inflammatory and Pro-inflammatory Factors in a Community-based Cohort Study.

Brain Behav Immun 2020 Jun 1. Epub 2020 Jun 1.

Department of Epidemiology and Public Health, University College London, UK.

Background: Differentials in COVID-19 hospitalisations and mortality according to ethnicity have been reported but their origin is uncertain. We examined the role of socioeconomic, mental health, and pro-inflammatory factors in a community-based sample.

Methods: We used data on 340,966 men and women (mean age 56. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.05.074DOI Listing

An experimental and algorithm-based study of the spectral features of breast cancer patients by a photodiagnosis approach.

Photodiagnosis Photodyn Ther 2020 Jun 1:101851. Epub 2020 Jun 1.

Department of Electrical Computer Engineering, COMSATS University Islambad, Islamabad Campus, Park Road, Chak Shahzad, Islamabad, 45550, Pakistan.

In the present study, the spectral diagnosis of blood plasma samples of breast cancer patients and an equal number of normal controls was investigated. A set of ratio parameters was acquired by employing SXS and FES. The samples were also analyzed statistically by employing Welch two-sample t-tests, and the effects of three ratio parameters, R, R, and R, were also studied by plotting them against the subject numbers. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101851DOI Listing

Pressure filtration properties of sludge generated in the electrochemical treatment of mining waters.

Water Res 2020 May 18;181:115922. Epub 2020 May 18.

Department of Separation Science, LUT School of Engineering Science, Lappeenranta-Lahti University of Technology, Yliopistonkatu 34, FI, 53850, Lappeenranta, Finland.

In this study, batch electrocoagulation (EC) experiments were performed with synthetic mining water in various conditions in a laboratory-scale 1L reactor. The process was scaled up and the selected results were verified with both synthetic and real mining water in a 70 L reactor. The generated solids were characterized by XRD, SEM, and a laser diffraction particle size analyzer. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115922DOI Listing

Characterization of lamprey (Lampetra japonica) tnfr10-like gene: A potential granulocyte marker molecule and its immune functions.

Mol Immunol 2020 Jun 1;124:25-34. Epub 2020 Jun 1.

College of Life Sciences, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China. Electronic address:

Tumor necrosis factor receptor superfamily (TNFRSF) is an ancient protein superfamily. By binding to tumor necrosis factor (TNF), it can participate in inflammatory response, apoptosis, lymphocyte homeostasis and tissue development. Seven TNFR members have previously been identified in lampreys but detailed functions of TNFR members are not yet to be resolved. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.05.015DOI Listing

Preparation and Characterization of Cyclodextrin Nanosponges for Organic Toxic Molecule Removal.

Int J Pharm 2020 Jun 1:119485. Epub 2020 Jun 1.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100, Ankara, Turkey. Electronic address:

Cyclodextrin-based nanosponges (CD-NS) are considered as safe and biocompatible systems for removing toxic molecules from the body. Rapid removal of toxic molecules that are formed in the body from certain food constituents, is relevant especially for patients affected by chronic kidney disease. Within the scope of this study, innovative cyclodextrin polymers were synthesized to form nanosponges able to remove indole, before it could form the toxic indoxyl sulfate in the body. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119485DOI Listing

Cardiac Irradiation Predicts Activity Decline in Patients Receiving Concurrent Chemoradiation for Locally Advanced Lung Cancer.

Int J Radiat Oncol Biol Phys 2020 Jun 1. Epub 2020 Jun 1.

Department of Radiation Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York. Electronic address:

Purpose: Many lung cancer patients are inactive due to their disease and underlying comorbidities, and activity levels can decline further during cancer therapy. Here we explore dosimetric predictors of activity decline in a cohort of patients who underwent continuous activity monitoring during definitive concurrent chemoradiotherapy (CRT) for locally advanced lung cancer.

Methods And Materials: We identified patients who participated in prospective clinical trials involving the use of a commercial fitness tracker throughout the course of CRT. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.05.042DOI Listing

Preparation of polymyxin B-loaded gellan-polylysine polyion complex fibers with high affinity to endotoxin.

Int J Biol Macromol 2020 Jun 1. Epub 2020 Jun 1.

Key Laboratory of Carbohydrate Chemistry and Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:

Endotoxemia, a life-threatening disease affecting people worldwide, can be treated by hemoperfusion alone. New hemoperfusion materials with high biocompatibility and endotoxin-combination ability are always in demand. Herein, polymyxin B (PMB), a specific endotoxin binding molecule, was loaded onto gellan-polylysine polyion complex, and the obtained material was used in preparing wet-spun fibers. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.263DOI Listing

2-[F]FDG PET/CT radiomics in lung cancer: an overview of the technical aspect and its emerging role in management of the disease.

Methods 2020 Jun 1. Epub 2020 Jun 1.

Department of Nuclear Medicine, University Hospital, RWTH University, Aachen, Germany; Department of Nuclear Medicine & Endocrinology, Paracelsus Medical University, Salzburg, Austria. Electronic address:

Lung cancer is the most common cancer, worldwide, and a major health issue with a remarkable mortality rate. 2-[F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (2-[F]FDG PET/CT) plays an indispensable role in the management of lung cancer patients. Long-established quantitative parameters such as size, density, and metabolic activity have been and are being employed in the current practice to enhance interpretation and improve diagnostic and prognostic value. Read More

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http://dx.doi.org/10.1016/j.ymeth.2020.05.023DOI Listing

Phenotypic characteristics of patients with Chronic Obstructive Pulmonary Disease after stratification for the Short Physical Performance Battery summary score.

Arch Phys Med Rehabil 2020 Jun 1. Epub 2020 Jun 1.

Department of Research and Development, CIRO, Horn, the Netherlands; Reval Rehabilitation Research - Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium; Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands.

Objective: To assess the phenotypic characteristics of patients with Chronic Obstructive Pulmonary Disease (COPD) after stratification for Short Physical Performance Battery (SPPB) summary scores and to determine phenotypic characteristics of the SPPB summary score at the start of pulmonary rehabilitation (PR).

Design: Retrospective, cross-sectional.

Setting: Baseline assessment for PR program. Read More

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http://dx.doi.org/10.1016/j.apmr.2020.05.011DOI Listing

Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis.

Comp Biochem Physiol B Biochem Mol Biol 2020 Jun 1:110461. Epub 2020 Jun 1.

Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa K1S 5B6, Canada. Electronic address:

In arid conditions, the African Clawed frog Xenopus laevis enters a state of estivation dormancy as an adaptive survival strategy. Under estivation, X. laevis experience severe dehydration stress as 25-35% of total body water is lost. Read More

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http://dx.doi.org/10.1016/j.cbpb.2020.110461DOI Listing

Reduced telomere shortening in lifelong trained male football players compared to age-matched inactive controls.

Prog Cardiovasc Dis 2020 Jun 1. Epub 2020 Jun 1.

Department of Sports Science and Clinical Biomechanics, SDU Sport and Health Sciences Cluster, University of Southern Denmark, Odense 3450, Denmark; Sport and Health Sciences, St Luke's Campus, University of Exeter, Exeter EX1 6JA, United Kingdom; Shanghai University of Sport, Shanghai, China. Electronic address:

Aims: Current evidence points to cellular anti-ageing effects of regular endurance training which may differ from other sport modalities. Effects of football training on markers of cell senescence have not been tested.

Methods: One hundred and forty healthy, non-smoking men participated in the study, including young elite football players aged 18-30 years (YF, n = 35, 21. Read More

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http://dx.doi.org/10.1016/j.pcad.2020.05.009DOI Listing

Diverse function and regulation of CmSnf1 in entomopathogenic fungus Cordyceps militaris.

Fungal Genet Biol 2020 Jun 1:103415. Epub 2020 Jun 1.

National Engineering Research Centre of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, P.R.China. Electronic address:

SNF1/AMPK protein kinases play important roles in fungal development and activation of catabolite-repressed genes. In this study, we characterized the role of SNF1 ortholog in Cordyceps militaris (CmSnf1). The vegetative growth of a CmSnf1 deletion mutant was (ΔCmSnf1) reduced by 42. Read More

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http://dx.doi.org/10.1016/j.fgb.2020.103415DOI Listing

Toxic and Physiological Metal Uptake and Release by Human Serum Transferrin.

Biophys J 2020 May 20. Epub 2020 May 20.

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California. Electronic address:

An atomistic understanding of metal transport in the human body is critical to anticipate the side effects of metal-based therapeutics and holds promise for new drugs and drug delivery designs. Human serum transferrin (hTF) is a central part of the transport processes because of its ubiquitous ferrying of physiological Fe(III) and other transition metals to tightly controlled parts of the body. There is an atomistic mechanism for the uptake process with Fe(III), but not for the release process, or for other metals. Read More

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http://dx.doi.org/10.1016/j.bpj.2020.05.006DOI Listing

Tail-phase safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in HIV-uninfected adults: a secondary analysis of the HPTN 077 trial.

Lancet HIV 2020 Jun 1. Epub 2020 Jun 1.

School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Background: Long-acting injectable cabotegravir is a novel integrase inhibitor currently in advanced clinical development for HIV prevention and treatment. We aimed to assess the terminal phase pharmacokinetics and safety of long-acting injectable cabotegravir in participants included in the HPTN 077 trial.

Methods: HPTN 077 was a multicentre, double-blind, randomised, placebo-controlled phase 2a trial done at eight sites in Brazil, Malawi, South Africa, and the USA. Read More

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http://dx.doi.org/10.1016/S2352-3018(20)30106-5DOI Listing

Pycnogenol achieves neuroprotective effects in rats with spinal cord injury by stabilizing the mitochondrial membrane potential.

Neurol Res 2020 Jun 4:1-8. Epub 2020 Jun 4.

Department of Orthopaedics, China Medical University First Hospital , Shenyang, Liaoning, China.

Objectives: In this study, we aimed to verify the neuroprotective effects of pycnogenol (PYC) on spinal cord injury (SCI) and to determine the underlying mechanisms.

Methods: Male Wistar rats were selected to establish a model of SCI in accordance with the Allen's protocol. The rats in the PYC group were treated with 100 mg/kg PYC by intraperitoneal injection 15 minutes after SCI. Read More

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http://dx.doi.org/10.1080/01616412.2020.1773610DOI Listing

Relationship between risky behaviors and non-prescription opioid use among Asian American youth.

J Ethn Subst Abuse 2020 Jun 4:1-10. Epub 2020 Jun 4.

University of Texas Health Science Center (UTHealth), Dallas, Texas.

Asian Americans (AA) are a highly understudied population and are often considered the "model minority" for health. However, there is a dearth of research on risky behaviors associated with opioid use in AA teens. Data among AA youth aged 12 to 16 was collected from the 2017 Youth Risk Behavior Surveillance System. Read More

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http://dx.doi.org/10.1080/15332640.2020.1772931DOI Listing

Novel drug delivery systems of β2 adrenoreceptor agonists to suppress SNCA gene expression and mitochondrial oxidative stress in Parkinson's disease management.

Expert Opin Drug Deliv 2020 Jun 4. Epub 2020 Jun 4.

Department of Pharmacology, JSS College of Pharmacy (A constituent college of JSS Academy of Higher Education & Research) , Ooty, 643 001, The Nilgiris, Tamil Nadu, India.

Introduction: α-synuclein (SNCA), a major component of Lewy body is a pathological hallmark of Parkinson's disease (PD). Mutations in the SNCA gene cause misfolding and aggregation of SNCA protein, which results in neurodegeneration. Several studies have established the neuroprotective benefits of β2-adrenoreceptor (β2AR) agonists in PD However, β2AR agonists are associated with peripheral side effects- tachycardia, palpitation, pulmonary edema, myocardial ischemia, and cardiac arrhythmia due to βARactivation in peripheral tissues. Read More

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http://dx.doi.org/10.1080/17425247.2020.1779218DOI Listing

Suppression of knee joint osteoarthritis induced secondary to type 2 diabetes mellitus in rats by resveratrol: role of glycated haemoglobin and hyperlipidaemia and biomarkers of inflammation and oxidative stress.

Arch Physiol Biochem 2020 Jun 4:1-8. Epub 2020 Jun 4.

Department of Basic Medical Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

We investigated whether the anti-inflammatory and antioxidant agent, resveratrol can inhibit type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and whether it is associated with the suppression of glycaemia, dyslipidemia and inflammatory and oxidative stress biomarkers. T2DM was induced by streptozotocin (50 mg/kg body weight) and high carbohydrate and fat diet (HCFD). The protective group was put on resveratrol (30 mg/kg) 14 days prior to the induction of diabetes and continued on resveratrol and HCFD until being sacrificed at week 12. Read More

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http://dx.doi.org/10.1080/13813455.2020.1771378DOI Listing

Determining the steering direction in critical situations: A decision tree-based method.

Traffic Inj Prev 2020 Jun 4:1-6. Epub 2020 Jun 4.

State Key Laboratory of Automotive Safety and Energy, School of Vehicle and Mobility, Tsinghua University, Beijing, China.

Factors related to the driver-vehicle-environment system have a significant influence on a driver's decision to perform evasive maneuvers, especially the decision of steering direction (DSD) in critical situations. However, few studies have systematically investigated the relationships between these factors and DSD. The objective of this study is to analyze and model drivers' DSD in critical situations. Read More

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http://dx.doi.org/10.1080/15389588.2020.1771326DOI Listing

The accurate prediction of sweat rate from energy expenditure and air temperature: A proof-of-concept study.

Appl Physiol Nutr Metab 2020 Jun 4. Epub 2020 Jun 4.

Sports Science Synergy, LLC , Franklin, MA , Franklin, Massachusetts, United States , 02038 ;

This proof-of-concept study used a web application to predict runner sweat losses using only energy expenditure and air temperature. A field study (FS) of n = 37 runners was completed with n = 40 sweat loss observations measured over one hour (sweat rate, SR). Predictions were also compared to 10 open literature (OL) studies where individual runner SR was reported (n = 82; 109 observations). Read More

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http://dx.doi.org/10.1139/apnm-2020-0236DOI Listing

Longitudinal development of hippocampal subregions from early- to mid-childhood.

Hippocampus 2020 Jun 4. Epub 2020 Jun 4.

Department of Psychology, University of Maryland, College Park, Maryland, USA.

Early childhood is characterized by vast changes in behaviors supported by the hippocampus and an increased susceptibility of the hippocampus to environmental influences. Thus, it is an important time to investigate the development of the hippocampus. Existing research suggests subregions of the hippocampus (i. Read More

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http://dx.doi.org/10.1002/hipo.23218DOI Listing

Urinary sodium-to-potassium ratio and body mass index in relation to high blood pressure in a national health survey in Chile.

J Clin Hypertens (Greenwich) 2020 Jun 4. Epub 2020 Jun 4.

División de Enfermedades Cardiovasculares, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Several lifestyle and sociodemographic factors are associated with blood pressure (BP). The authors conducted a retrospective study of 4870 subjects from the National Health Survey 2009 in Chile to identify exposure factors associated with increasing BP levels. Subjects with isolated urinary excretion of sodium (n = 2873), potassium, and creatinine were included to estimate daily salt intake and urinary sodium/potassium (Na/K) ratio. Read More

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http://dx.doi.org/10.1111/jch.13904DOI Listing

DXA measured body composition predicts blood pressure using machine learning methods.

J Clin Hypertens (Greenwich) 2020 Jun 4. Epub 2020 Jun 4.

Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/jch.13914DOI Listing

Overall and chemotherapy-free survival following stereotactic body radiation therapy for abdominopelvic oligometastases.

J Med Imaging Radiat Oncol 2020 Jun 4. Epub 2020 Jun 4.

Department of Oncology, McMaster University/Juravinski Cancer Centre, Hamilton, Ontario, Canada.

Introduction: Limited data establish the efficacy and safety of SBRT in the abdominopelvic (AP) space, where SBRT delivery is challenging due to the proximity of radiosensitive luminal gastrointestinal (GI) organs. The aim of this study was to assess clinical outcomes in patients with AP OM treated with SBRT.

Methods: Eligible patients were those with OM (defined as metastases in ≤3 total sites) in the AP space (excluding liver) treated with SBRT. Read More

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http://dx.doi.org/10.1111/1754-9485.13057DOI Listing

Stimulation of Retrotrapezoid Nucleus Phox2b-expressing Neurons Rescues Breathing Dysfunction in an Experimental Parkinson's Disease Rat Model.

Brain Pathol 2020 Jun 4. Epub 2020 Jun 4.

Department of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo (USP), 05508-000, São Paulo, SP, Brazil.

Emerging evidence from multiple studies indicates that Parkinson's disease (PD) patients suffer from a spectrum of autonomic and respiratory motor deficiencies in addition to the classical motor symptoms attributed to substantia nigra degeneration of dopaminergic neurons. Animal models of PD show a decrease in the resting respiratory rate as well as a decrease in the number of Phox2b-expressing retrotrapezoid nucleus (RTN) neurons. The aim of this study was to determine the extent to which substantia nigra pars compact (SNc) degeneration induced RTN biomolecular changes and to identify the extent to which RTN pharmacological or optogenetic stimulations rescue respiratory function following PD-induction. Read More

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http://dx.doi.org/10.1111/bpa.12868DOI Listing

Population Pharmacokinetics of Olanzapine in Children.

Br J Clin Pharmacol 2020 Jun 4. Epub 2020 Jun 4.

See Acknowledgments for a listing of committee members.

Aims: To evaluate the population pharmacokinetics (PopPK) of olanzapine in children and devise a model-informed pediatric dosing scheme.

Method: The PopPK of olanzapine was characterized using opportunistically collected plasma samples from children receiving olanzapine per standard of care for any indication. A nonlinear mixed effect modeling approach was employed for model development using the software NONMEM (v7. Read More

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http://dx.doi.org/10.1111/bcp.14414DOI Listing

The functional nutritional and regulatory activities of calcium supplementation from eggshell for obesity disorders management.

J Food Biochem 2020 Jun 4:e13313. Epub 2020 Jun 4.

Faculty of Science, Zoology Department, Suez University, Suez, Egypt.

The present study was to investigate the effective role of renewable sources of Ca from eggshell (ES) with different doses to restrict obesity disorders. Rats were classified as follows, G : normal diet for 26 weeks; G : high-fat diet (HFD) for 26 weeks; G , G , and G were supplemented with HFD for 16 weeks and treated with 7.2 g Ca ES/Kg rat chow, 18 g Ca ES/Kg rat chow, and 2% diet containing fat (DCF), respectively, for the remaining 10 weeks. Read More

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http://dx.doi.org/10.1111/jfbc.13313DOI Listing

Obesity, race, and long-term prostate cancer outcomes.

Cancer 2020 Jun 4. Epub 2020 Jun 4.

Urology Section, Department of Surgery, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California.

Background: The authors previously found that obesity was linked with prostate cancer (PC)-specific mortality (PCSM) among men who underwent radical prostatectomy (RP). Herein, in a larger RP cohort, the authors investigated whether the association between obesity and long-term PC outcomes, including PCSM, differed by race.

Methods: Data from 5929 patients who underwent RP and were in the Shared Equal Access Regional Cancer Hospital (SEARCH) database were analyzed. Read More

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http://dx.doi.org/10.1002/cncr.32906DOI Listing

Efficacy of oral sarolaner against Lynxacarus radovskyi in naturally infested cats.

Vet Dermatol 2020 Jun 4. Epub 2020 Jun 4.

Animal Parasitology Department, Veterinary Institute, Federal Rural University of Rio de Janeiro, BR 465, Km 7, 23897-000, Seropédica, RJ, Brazil.

Background: Lynxacarus radovskyi is a fur mite of cats. Several classes of ectoparasiticides have shown success for treatment, including an isoxazoline.

Objectives: To evaluate the efficacy of a single oral dose of sarolaner for the treatment of L. Read More

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http://dx.doi.org/10.1111/vde.12857DOI Listing

Patients who report cording after breast cancer surgery are at higher risk of lymphedema: Results from a large prospective screening cohort.

J Surg Oncol 2020 Jun 4. Epub 2020 Jun 4.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.

Objectives: To identify the association between cording and breast cancer-related lymphedema (BCRL); describe time course, location, symptoms and functional impairments.

Methods: A total of 1181 patients were prospectively screened for BCRL after breast cancer (BC) surgery, including patient-reported outcome measures (4193) and perometric arm volume measurements (BCRL defined as relative or weight-adjusted volume change [RVC or WAC] ≥10% ≥3 months postoperatively).

Results: A total of 374/1181 patients (31. Read More

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http://dx.doi.org/10.1002/jso.25944DOI Listing

A lesson from a saboteur: high molecular weight kininogen (HMWK) impact in COVID-19.

Br J Pharmacol 2020 Jun 4. Epub 2020 Jun 4.

Department of Pharmacy (DIFARMA), University of Salerno, Via Giovanni Paolo II, 132, Fisciano, 84084, Italy.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly identified coronavirus which has spread from China to the rest of the world causing the pandemic coronavirus disease 19 (COVID-19). It has fatality rate that floats from 5 to 15% and the symptoms are fever, cough, myalgia and/or fatigue up to dyspnea, responsible for hospitalization and in most of the cases of artificial oxygenation. In the attempt to understand how the virus spreads and how to pharmacologically abolish it, it was highlighted that SARS-CoV-2 infects human cells by means of angiotensin converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2) and SARS-CoV-2 main protease (M ). Read More

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http://dx.doi.org/10.1111/bph.15154DOI Listing

The Dancing Cord: Inherent Spinal Cord Motion and Its Effect on Cord Dose in Spine Stereotactic Body Radiation Therapy.

Neurosurgery 2020 Jun 4. Epub 2020 Jun 4.

Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington.

Background: Spinal cord dose limits are critically important for the safe practice of spine stereotactic body radiotherapy (SBRT). However, the effect of inherent spinal cord motion on cord dose in SBRT is unknown.

Objective: To assess the effects of cord motion on spinal cord dose in SBRT. Read More

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http://dx.doi.org/10.1093/neuros/nyaa202DOI Listing
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