13,230 results match your criteria Bmc Pharmacology & Toxicology[Journal]


Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer.

Authors:
Manuel A Ferreira Eric R Gamazon Fares Al-Ejeh Kristiina Aittomäki Irene L Andrulis Hoda Anton-Culver Adalgeir Arason Volker Arndt Kristan J Aronson Banu K Arun Ella Asseryanis Jacopo Azzollini Judith Balmaña Daniel R Barnes Daniel Barrowdale Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Katarzyna Białkowska Carl Blomqvist Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Ake Borg Hiltrud Brauch Hermann Brenner Annegien Broeks Barbara Burwinkel Trinidad Caldés Maria A Caligo Daniele Campa Ian Campbell Federico Canzian Jonathan Carter Brian D Carter Jose E Castelao Jenny Chang-Claude Stephen J Chanock Hans Christiansen Wendy K Chung Kathleen B M Claes Christine L Clarke Fergus J Couch Angela Cox Simon S Cross Kamila Czene Mary B Daly Miguel de la Hoya Joe Dennis Peter Devilee Orland Diez Thilo Dörk Alison M Dunning Miriam Dwek Diana M Eccles Bent Ejlertsen Carolina Ellberg Christoph Engel Mikael Eriksson Peter A Fasching Olivia Fletcher Henrik Flyger Eitan Friedman Debra Frost Marike Gabrielson Manuela Gago-Dominguez Patricia A Ganz Susan M Gapstur Judy Garber Montserrat García-Closas José A García-Sáenz Mia M Gaudet Graham G Giles Gord Glendon Andrew K Godwin Mark S Goldberg David E Goldgar Anna González-Neira Mark H Greene Jacek Gronwald Pascal Guénel Christopher A Haiman Per Hall Ute Hamann Wei He Jane Heyworth Frans B L Hogervorst Antoinette Hollestelle Robert N Hoover John L Hopper Peter J Hulick Keith Humphreys Evgeny N Imyanitov Claudine Isaacs Milena Jakimovska Anna Jakubowska Paul A James Ramunas Janavicius Rachel C Jankowitz Esther M John Nichola Johnson Vijai Joseph Beth Y Karlan Elza Khusnutdinova Johanna I Kiiski Yon-Dschun Ko Michael E Jones Irene Konstantopoulou Vessela N Kristensen Yael Laitman Diether Lambrechts Conxi Lazaro Goska Leslie Jenny Lester Fabienne Lesueur Sara Lindström Jirong Long Jennifer T Loud Jan Lubiński Enes Makalic Arto Mannermaa Mehdi Manoochehri Sara Margolin Tabea Maurer Dimitrios Mavroudis Lesley McGuffog Alfons Meindl Usha Menon Kyriaki Michailidou Austin Miller Marco Montagna Fernando Moreno Lidia Moserle Anna Marie Mulligan Katherine L Nathanson Susan L Neuhausen Heli Nevanlinna Ines Nevelsteen Finn C Nielsen Liene Nikitina-Zake Robert L Nussbaum Kenneth Offit Edith Olah Olufunmilayo I Olopade Håkan Olsson Ana Osorio Janos Papp Tjoung-Won Park-Simon Michael T Parsons Inge Sokilde Pedersen Ana Peixoto Paolo Peterlongo Paul D P Pharoah Dijana Plaseska-Karanfilska Bruce Poppe Nadege Presneau Paolo Radice Johanna Rantala Gad Rennert Harvey A Risch Emmanouil Saloustros Kristin Sanden Elinor J Sawyer Marjanka K Schmidt Rita K Schmutzler Priyanka Sharma Xiao-Ou Shu Jacques Simard Christian F Singer Penny Soucy Melissa C Southey John J Spinelli Amanda B Spurdle Jennifer Stone Anthony J Swerdlow William J Tapper Jack A Taylor Manuel R Teixeira Mary Beth Terry Alex Teulé Mads Thomassen Kathrin Thöne Darcy L Thull Marc Tischkowitz Amanda E Toland Diana Torres Thérèse Truong Nadine Tung Celine M Vachon Christi J van Asperen Ans M W van den Ouweland Elizabeth J van Rensburg Ana Vega Alessandra Viel Qin Wang Barbara Wappenschmidt Jeffrey N Weitzel Camilla Wendt Robert Winqvist Xiaohong R Yang Drakoulis Yannoukakos Argyrios Ziogas Peter Kraft Antonis C Antoniou Wei Zheng Douglas F Easton Roger L Milne Jonathan Beesley Georgia Chenevix-Trench

Nat Commun 2019 Apr 15;10(1):1741. Epub 2019 Apr 15.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. Read More

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http://dx.doi.org/10.1038/s41467-018-08053-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465407PMC
April 2019
1 Read

Acute Cocaine Enhances Dopamine DR Recognition and Signaling and Counteracts DR Internalization in Sigma1R-DR Heteroreceptor Complexes.

Mol Neurobiol 2019 Apr 10. Epub 2019 Apr 10.

Department of Neuroscience, Karolinska Institutet, Biomedicum (B0851). Solnavägen 9, 171 77, Stockholm, Sweden.

The current study was performed to establish the actions of nanomolar concentrations of cocaine, not blocking the dopamine transporter, on dopamine D2 receptor (DR)-sigma 1 receptor (δ1R) heteroreceptor complexes and the DR protomer recognition, signaling and internalization in cellular models. We report the existence of DR-δ1R heteroreceptor complexes in subcortical limbic areas as well as the dorsal striatum, with different distribution patterns using the in situ proximity ligation assay. Also, through BRET, these heteromers were demonstrated in HEK293 cells. Read More

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http://dx.doi.org/10.1007/s12035-019-1580-8DOI Listing

A pharmacogenetic study of patients with schizophrenia from West Siberia gets insight into dopaminergic mechanisms of antipsychotic-induced hyperprolactinemia.

BMC Med Genet 2019 Apr 9;20(Suppl 1):47. Epub 2019 Apr 9.

Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya str., 4, Tomsk, Russian Federation, 634014.

Background: Hyperprolactinemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 receptors (DRD2s) on the membranes of lactotroph cells within the pituitary gland. Certain antipsychotic drugs, e.g. Read More

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http://dx.doi.org/10.1186/s12881-019-0773-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454588PMC
April 2019
2 Reads

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study.

BMC Med 2019 Apr 8;17(1):76. Epub 2019 Apr 8.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool and The Royal Liverpool and Broadgreen University Hospitals NHS Trust, members of Liverpool Health Partners, Liverpool, UK.

Background: Warfarin is a widely used oral anticoagulant. Determining the correct dose required to maintain the international normalised ratio (INR) within a therapeutic range can be challenging. In a previous trial, we showed that a dosing algorithm incorporating point-of-care genotyping information ('POCT-GGD' approach) led to improved anticoagulation control. Read More

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http://dx.doi.org/10.1186/s12916-019-1308-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454722PMC

Schistosoma mansoni infection among preschool age children attending Erer Health Center, Ethiopia and the response rate to praziquantel.

BMC Res Notes 2019 Apr 5;12(1):211. Epub 2019 Apr 5.

Department of Microbiology Immunology and Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Objective: Preschool age children (PSAC) are excluded from community based praziquantel treatment programs mainly due to paucity of evidence on the magnitude of schistosomiasis, efficacy and safety of this treatment in PSAC. The aim of this study is to assess Schistosoma mansoni infection rate and evaluate response to praziquantel in PSAC. A facility based longitudinal study was employed from April to June 2016 at Erer Health Center, Eastern Ethiopia. Read More

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http://dx.doi.org/10.1186/s13104-019-4246-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451229PMC
April 2019
1 Read

Acceptance of interprofessional learning between medical and pharmacy students in a prescribing skills training workshop: pre-post intervention study.

BMC Med Educ 2019 Apr 5;19(1):101. Epub 2019 Apr 5.

Medical Education and Research Development Unit (MERDU), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: The success of interprofessional collaboration in healthcare services requires a paradigm shift in the training of future health profession practitioners. This study aimed to develop and validate an instrument to measure Student Acceptance of Interprofessional Learning (SAIL) in Malaysia, and to assess this attribute among medical and pharmacy students using a prescribing skills training workshop.

Methods: The study consisted of two phases. Read More

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http://dx.doi.org/10.1186/s12909-019-1525-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451269PMC
April 2019
1 Read

Association of first trimester maternal vitamin D, ferritin and hemoglobin level with third trimester fetal biometry: result from cohort study on vitamin D status and its impact during pregnancy and childhood in Indonesia.

BMC Pregnancy Childbirth 2019 Apr 2;19(1):112. Epub 2019 Apr 2.

dr Hasan Sadikin Hospital, Bandung, Indonesia.

Introduction: The role of vitamin D in placental functions and fetal growth had been addressed in many reports with conflicting results. However, such report is limited for Indonesian population. The aim of this study was to explore the association between maternal vitamin D level in the first trimester and fetal biometry in the later stage of pregnancy with adjusted OR for other determinants like hemoglobin and ferritin level. Read More

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http://dx.doi.org/10.1186/s12884-019-2263-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446282PMC

How exposure to ALS-inhibiting gametocide tribenuron-methyl induces male sterility in rapeseed.

BMC Plant Biol 2019 Apr 2;19(1):124. Epub 2019 Apr 2.

College of Agronomy, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Background: Acetolactate synthase (ALS)-inhibiting herbicide tribenuron-methyl (TBM) is an efficient gametocide that can cause rapeseed (Brassica napus L.) to become male sterile and outcrossing. To find the reason the TBM treatment leads to male sterility, an integrated study using cytological, physiological, and transcriptomic methods was conducted. Read More

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https://bmcplantbiol.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12870-019-1722-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444545PMC
April 2019
6 Reads

Knowledge about the administration and regulation of high alert medications among nurses in Palestine: a cross-sectional study.

BMC Nurs 2019 20;18:11. Epub 2019 Mar 20.

2Division of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839 Palestine.

Background: Medication errors (MEs) are unintended failures in the drug treatment process that can occur during prescription, dispensing, storing, preparation or administration of medications. High alert medications (HAMs) are defined as those medications that bear the highest risk of causing significant patient harm when used incorrectly, either due to their serious adverse events or to a narrow therapeutic window. Nurses are responsible for administration of HAMs; incorrect administration can have a significant clinical outcome. Read More

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https://bmcnurs.biomedcentral.com/articles/10.1186/s12912-01
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http://dx.doi.org/10.1186/s12912-019-0336-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425670PMC
March 2019
9 Reads

The TECTA mutation R1890C is identified as one of the causes of genetic hearing loss: a case report.

BMC Med Genet 2019 Apr 1;20(1):57. Epub 2019 Apr 1.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.

Background: Many mutations in the α-tectorin gene (TECTA) have been reported to cause non-syndromic hearing loss (NSHL) in either a dominant or recessive inheritance pattern. Among the identified TECTA mutations, H1400Y has been associated with NSHL in two independent studies. However, its exact role in contributing to genetic hearing loss remains elusive. Read More

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http://dx.doi.org/10.1186/s12881-019-0775-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444877PMC
April 2019
1 Read

Assessment of agreement and interchangeability between the TEG5000 and TEG6S thromboelastography haemostasis analysers: a prospective validation study.

BMC Anesthesiol 2019 Mar 30;19(1):45. Epub 2019 Mar 30.

Department of Anaesthesia, Austin Hospital, 145 Studley Rd, Heidelberg, Victoria, 3084, Australia.

Background: TEG6S® and TEG5000® (Haemonetics Corp, USA) are haemostasis analysers that measure viscoelasticity properties of whole blood. Both use different mechanisms to assess similar components of the coagulation process. The aim of this study was to assess agreement and interchangeability between the TEG6S and TEG5000 analysers. Read More

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http://dx.doi.org/10.1186/s12871-019-0717-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441230PMC
March 2019
1 Read

Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial.

BMC Complement Altern Med 2019 Mar 29;19(1):77. Epub 2019 Mar 29.

Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Republic of Korea.

Background: Cordyceps is a traditional Chinese herb that produces various biopharmaceutical effects, including immune-enhancing effects. In this study, we prepared a Cordyceps mycelium culture extract (Paecilomyces hepiali, CBG-CS-2) to confirm its efficacy in enhancing the immune system and to evaluate its safety in healthy adults.

Methods: Healthy adults were divided into the intervention group (n = 39), who were given 1. Read More

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http://dx.doi.org/10.1186/s12906-019-2483-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441223PMC

Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq.

BMC Genomics 2019 Mar 29;20(1):249. Epub 2019 Mar 29.

Epigenomics Development Laboratory, Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Stabile building 12-04, 200 First Street SW, Rochester, MN, 55905, USA.

Background: Epigenetic dysregulation is involved in the etiology and progression of various human diseases. Formalin-fixed paraffin-embedded (FFPE) samples represent the gold standard for archiving pathology samples, and thus FFPE samples are a major resource of samples in clinical research. However, chromatin-based epigenetic assays in the clinical settings are limited to fresh or frozen samples, and are hampered by low chromatin yield in FFPE samples due to the lack of a reliable and efficient chromatin preparation method. Read More

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http://dx.doi.org/10.1186/s12864-019-5639-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440302PMC

Reduced transient receptor potential vanilloid 2 expression in alveolar macrophages causes COPD in mice through impaired phagocytic activity.

BMC Pulm Med 2019 Mar 26;19(1):70. Epub 2019 Mar 26.

Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Background: Defective phagocytosis in alveolar macrophages is associated with chronic obstructive pulmonary disease (COPD). Transient receptor potential cation channel subfamily V member 2 (TRPV2), a type of nonselective cation channel pertinent to diverse physiological functions, regulates macrophage phagocytosis. However, the role of TRPV2 in COPD remains poorly understood. Read More

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http://dx.doi.org/10.1186/s12890-019-0821-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434859PMC
March 2019
1 Read

Differential genome-wide DNA methylation patterns in childhood obesity.

BMC Res Notes 2019 Mar 25;12(1):174. Epub 2019 Mar 25.

Department of Psychiatry, McGill University and Douglas Hospital Research Centre, Montreal, QC, Canada.

Objective: Exposure to stress during pregnancy may program susceptibility to the development of obesity in offspring. Our goal was to determine whether prenatal maternal stress (PNMS) due to a natural disaster was associated with child obesity, and to compare the DNA methylation profiles in obese versus non-obese children at age 13½ years. Women and their children were involved in the longitudinal natural disaster study-Project Ice Strom, which served as a human model to study PNMS. Read More

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http://dx.doi.org/10.1186/s13104-019-4189-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434834PMC

Deciphering the mechanism of Indirubin and its derivatives in the inhibition of Imatinib resistance using a "drug target prediction-gene microarray analysis-protein network construction" strategy.

BMC Complement Altern Med 2019 Mar 25;19(1):75. Epub 2019 Mar 25.

Department of Oncology, Affilited Hospital of Weifang Medical University, Weifang, 261031, Shandong, People's Republic of China.

Background: The introduction of imatinib revolutionized the treatment of chronic myeloid leukaemia (CML), substantially extending patient survival. However, imatinib resistance is currently a clinical problem for CML. It is very importantto find a strategy to inhibit imatinib resistance. Read More

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http://dx.doi.org/10.1186/s12906-019-2471-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434895PMC
March 2019
1 Read
2.020 Impact Factor

In vitro evaluation of the α-glucosidase inhibitory potential of methanolic extracts of traditionally used antidiabetic plants.

BMC Complement Altern Med 2019 Mar 25;19(1):74. Epub 2019 Mar 25.

Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

Background: Different plant parts of Roylea cinerea (D. Don) Baill. (Lamiaceae), Clematis grata Wall. Read More

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http://dx.doi.org/10.1186/s12906-019-2482-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434821PMC

Correction to: Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells.

BMC Cancer 2019 03 21;19(1):257. Epub 2019 Mar 21.

Louisiana State University Health Sciences Center, Shreveport, LA, USA.

Following publication of the original article [1], the author noticed the following errors in the article. Read More

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http://dx.doi.org/10.1186/s12885-019-5458-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429697PMC
March 2019
3.362 Impact Factor

Effects of hydroalcoholic extract of Solidago chilensis Meyen on nociception and hypernociception in rodents.

BMC Complement Altern Med 2019 Mar 20;19(1):72. Epub 2019 Mar 20.

Department of Health Sciences, Universidade Estadual de Santa Cruz, BR-415, Rodovia Ilhéus- Itabuna, Km-16, Salobrinho, Ilhéus, Bahia, 45662-000, Brazil.

Background: Solidago chilensis (syn. microglossa) is a plant from the Asteraceae family widely distributed in South America and used to treat inflammatory diseases. In 2009, it was listed as one of the native medicinal herbal plants used in the Brazilian public health system. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s12906-019-2478-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427863PMC
March 2019
2 Reads

Inhibition of extracellular proteases improves the production of a xylanase in Parageobacillus thermoglucosidasius.

BMC Biotechnol 2019 03 20;19(1):17. Epub 2019 Mar 20.

Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

Background: Parageobacillus thermoglucosidasius is a thermophilic and ethanol-producing bacterium capable of utilising both hexose and pentose sugars for fermentation. The organism has been proposed to be a suitable organism for the production of bioethanol from lignocellulosic feedstocks. These feedstocks may be difficult to degrade, and a potential strategy to optimise this process is to engineer strains that secrete hydrolases that liberate increased amounts of sugars from those feedstocks. Read More

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http://dx.doi.org/10.1186/s12896-019-0511-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425571PMC

ApoE4: an emerging therapeutic target for Alzheimer's disease.

BMC Med 2019 Mar 20;17(1):64. Epub 2019 Mar 20.

Department of Neurobiology, Sagol School of Neurosciences, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 6997801, Tel Aviv, Israel.

Background: The growing body of evidence indicating the heterogeneity of Alzheimer's disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy, suggest that the development of a single magic cure suitable for all cases may not be possible. This calls for a shift in paradigm where targeted treatment is developed for specific AD subpopulations that share distinct genetic or pathological properties. Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor of AD, is expressed in more than half of AD patients and is thus an important possible AD therapeutic target. Read More

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http://dx.doi.org/10.1186/s12916-019-1299-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425600PMC
March 2019
5 Reads

Exogenous 2-(3,4-Dichlorophenoxy) triethylamine ameliorates the soil drought effect on nitrogen metabolism in maize during the pre-female inflorescence emergence stage.

BMC Plant Biol 2019 Mar 19;19(1):107. Epub 2019 Mar 19.

College of Agriculture, Northeast Agricultural University, No. 600, Changjiang Street, Xiangfang District, Harbin, China.

Background: Nitrogen (N) metabolism plays an important role in plant drought tolerance. 2-(3,4-Dichlorophenoxy) triethylamine (DCPTA) regulates many aspects of plant development; however, the effects of DCPTA on soil drought tolerance are poorly understood, and the possible role of DCPTA on nitrogen metabolism has not yet been explored.

Results: In the present study, the effects of DCPTA on N metabolism in maize (Zea mays L. Read More

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http://dx.doi.org/10.1186/s12870-019-1710-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425708PMC

Ocimum gratissimum Linn. Leaves reduce the key enzymes activities relevant to erectile dysfunction in isolated penile and testicular tissues of rats.

BMC Complement Altern Med 2019 Mar 19;19(1):71. Epub 2019 Mar 19.

Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, 3886, South Africa.

Background: Ocimum gratissimum L. is a medicinal plant widely grown in tropical and subtropical regions with the leaf decoction usually taken in folk medicine to enhance erectile performance in men although the probable mechanism of actions remains undetermined. This study examined the inhibitory potentials of Ocimum gratissimum leaves on some key enzymes associated with erectile dysfunction in penile and testicular tissues of the rat. Read More

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http://dx.doi.org/10.1186/s12906-019-2481-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425690PMC
March 2019
2.020 Impact Factor

Invitro synergistic activity of lactic acid bacteria against multi-drug resistant staphylococci.

BMC Complement Altern Med 2019 Mar 19;19(1):70. Epub 2019 Mar 19.

Department of Microbial Biotechnology, Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth (Deemed to be) University, Katraj, Pune, 411046, India.

Background: Multi-drug resistance in microorganisms is a serious problem at national as well as at a global level. Many researches have suggested alternatives to antibiotics with minimal or no major side effects. LAB is one of the most human-friendly probiotic strains known to mankind from times immemorial. Read More

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http://dx.doi.org/10.1186/s12906-019-2470-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425562PMC
March 2019
2 Reads

Relapse rates after elective discontinuation of anti-TNF therapy in rheumatoid arthritis: a meta-analysis and review of literature.

BMC Rheumatol 2019 8;3:10. Epub 2019 Mar 8.

6Department of Rheumatology and Rehabilitation, Tanta University Faculty of Medicine, Elgesh Street, Tanta, Gharbeia Egypt.

Background: Inhibitors of tumor necrosis factor alpha (TNF-α) are current mainstay of therapies for rheumatoid arthritis (RA). The decision when to withdraw TNF-α inhibitors after achieving remission and the incidence of relapse rates with elective discontinuation are both important questions that demand intense survey in these patients. In this meta-analysis we aimed to estimate the magnitude of relapse rate after elective TNF-α inhibitor discontinuation in RA patients with remission. Read More

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http://dx.doi.org/10.1186/s41927-019-0058-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408847PMC
March 2019
1 Read

In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494).

BMC Rheumatol 2018 28;2:23. Epub 2018 Aug 28.

1Immunology Discovery Research, AbbVie Bioresearch Center, 100 Research Dr, Worcester, MA 01605 USA.

Background: Anti-cytokine therapies such as adalimumab, tocilizumab, and the small molecule JAK inhibitor tofacitinib have proven that cytokines and their subsequent downstream signaling processes are important in the pathogenesis of rheumatoid arthritis. Tofacitinib, a pan-JAK inhibitor, is the first approved JAK inhibitor for the treatment of RA and has been shown to be effective in managing disease. However, in phase 2 dose-ranging studies tofacitinib was associated with dose-limiting tolerability and safety issues such as anemia. Read More

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http://dx.doi.org/10.1186/s41927-018-0031-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390583PMC

Assessment of hypertension control and factors associated with the control among hypertensive patients attending at Zewditu Memorial Hospital: a cross sectional study.

BMC Res Notes 2019 Mar 18;12(1):152. Epub 2019 Mar 18.

Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Objective: This study was conducted to assess hypertension control and factors associated with it among hypertensive patients on treatment at Zewditu Memorial Hospital.

Results: A total of 225 patients were included in the study, of which 55.6% of patients were females. Read More

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http://dx.doi.org/10.1186/s13104-019-4173-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423777PMC

Radiological and clinical outcomes of cervical disc arthroplasty for the elderly: a comparison with young patients.

BMC Musculoskelet Disord 2019 Mar 18;20(1):115. Epub 2019 Mar 18.

Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Room 525, 17F, #201, Shih-Pai Road, Sec. 2, Beitou District, Taipei, 11217, Taiwan.

Background: This study aimed to investigate whether cervical disc arthroplasty (CDA) would be equally effective in elderly patients as in the young. The inclusion criteria of published clinical trials for CDA-enrolled patients covered the ages from 18 to 78 years. However, there was a paucity of data addressing the differences of outcomes between older and the younger patients. Read More

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http://dx.doi.org/10.1186/s12891-019-2509-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421705PMC
March 2019
1 Read

The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines.

BMC Cancer 2019 Mar 18;19(1):243. Epub 2019 Mar 18.

Institute of Pharmacogenetics, University Hospital Essen, Essen, Germany.

Background: High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach, but previous studies suggest that a combined inhibition of Bcl-2 and Mcl-1 is necessary. TW-37 inhibits Mcl-1 and Bcl-2 with almost the same affinity. Read More

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http://dx.doi.org/10.1186/s12885-019-5439-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423774PMC
March 2019
1 Read

Traditional Chinese medicine formulation Yanggan Jiedu Sanjie inhibits TGF-β1-induced epithelial-mesenchymal transition and metastatic potential in human hepatocarcinoma Bel-7402 cells.

BMC Complement Altern Med 2019 Mar 15;19(1):67. Epub 2019 Mar 15.

Institute of Traditional Chinese Medicine in Oncology, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People's Republic of China.

Background: Epithelial-mesenchymal transition (EMT) is a vital process in cancer progression and metastasis. Yanggan Jiedu Sanjie (YGJDSJ) is Traditional Chinese Medicine formulation for liver cancer treatment. In the present study, we evaluated the effects of YGJDSJ on TGF-β1-induced EMT in hepatocellular carcinoma Bel-7402 cells. Read More

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http://dx.doi.org/10.1186/s12906-019-2477-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420768PMC

FitEllipsoid: a fast supervised ellipsoid segmentation plugin.

BMC Bioinformatics 2019 Mar 15;20(1):142. Epub 2019 Mar 15.

ITAV, CNRS, Université de Toulouse, 1 Pl. Pierre Potier, Toulouse, 31106, France.

Background: The segmentation of a 3D image is a task that can hardly be automatized in certain situations, notably when the contrast is low and/or the distance between elements is small. The existing supervised methods require a high amount of user input, e.g. Read More

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http://dx.doi.org/10.1186/s12859-019-2673-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419800PMC

Assessment of nutritional status in the maintenance of haemodialysis patients: a cross-sectional study from Palestine.

BMC Nephrol 2019 Mar 15;20(1):92. Epub 2019 Mar 15.

Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.

Background: Protein-energy wasting (PEW) is a relatively prevalent problem among adult haemodialysis patients (HDP). PEW is an important determinant of morbidity and mortality in HDP, therefore it is essential for dietitians to accurately assess malnutrition (MN) in these patients. HDP appear to be more susceptible to developing MN; however, this is not well documented. Read More

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http://dx.doi.org/10.1186/s12882-019-1288-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420767PMC
March 2019
1 Read
1.520 Impact Factor

Antimicrobial use for selected diseases in cats in Switzerland.

BMC Vet Res 2019 Mar 14;15(1):94. Epub 2019 Mar 14.

Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057, Zurich, Switzerland.

Background: Antibiotic use in human and veterinary medicine is considered a main driver of antimicrobial resistance. Although guidelines to promote appropriate use of antimicrobials in veterinary patients have been developed, antibiotic overprescription is assumed to be a common problem. The goal of this study was to investigate antimicrobial use in cats in Switzerland with acute upper respiratory tract disease (aURTD), feline lower urinary tract disease (FLUTD) and abscesses, and to assess compliance of prescription with consensus guidelines. Read More

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http://dx.doi.org/10.1186/s12917-019-1821-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417182PMC
March 2019
2 Reads

Effects of a combination of herbal extracts (modified Ojayeonjonghwan (Wuzi Yanzong wan)) on partial urethral obstruction-induced detrusor overactivity in rats: impact on the nitric oxide pathway and oxidative stress.

BMC Complement Altern Med 2019 Mar 14;19(1):64. Epub 2019 Mar 14.

Department of Urology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: We investigated the effects of a berry mixture formula (modified Ojayeonjonghwan (Wuzi Yanzong Wan, MO formula) on detrusor overactivity (DO).

Methods: The MO formula consisted of 5 seeds obtained from 5 types of berry plants. Twenty-four Sprague-Dawley rats were randomly assigned to four groups: sham-operated (control), partial urethral obstruction-induced DO (DO group), 0. Read More

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http://dx.doi.org/10.1186/s12906-019-2467-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419416PMC
March 2019
2 Reads

Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicine.

BMC Complement Altern Med 2019 Mar 12;19(1):57. Epub 2019 Mar 12.

The K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.

Background: Prolonged hyperuricemia is associated with kidney disease or gouty arthritis. Whether Yokuininto, a commercially available Kampo medicine that has been used for osteoarthritis or rheumatoid arthritis, can exhibit anti-hyperuricemic and inflammatory effects remains elusive. In the present study, Yokuininto exerts multiple homeostatic action on serum uric acid (sUA) levels by blocking pro-inflammatory cytokine activities and inducing uricosuric function with anti-renal injury functions. Read More

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http://dx.doi.org/10.1186/s12906-019-2469-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419507PMC
March 2019
1 Read

Green cardamom supplementation improves serum irisin, glucose indices, and lipid profiles in overweight or obese non-alcoholic fatty liver disease patients: a double-blind randomized placebo-controlled clinical trial.

BMC Complement Altern Med 2019 Mar 12;19(1):59. Epub 2019 Mar 12.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Background: Despite the reported health effects of cardamom on dyslipidemia, hepatomegaly, and fasting hyperglycemia, no human research has studied its potency in non-alcoholic fatty liver disease (NAFLD) as the hepatic part of metabolic syndrome. Our aim was determining the effects of green cardamom (GC) on serum glucose indices, lipids, and irisin level among overweight or obese NAFLD patients.

Methods: The place of participant recruitment was the polyclinic of the National Iranian Oil Company (NIOC) central hospital in Tehran. Read More

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http://dx.doi.org/10.1186/s12906-019-2465-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419418PMC
March 2019
3 Reads
2.020 Impact Factor

TADKB: Family classification and a knowledge base of topologically associating domains.

BMC Genomics 2019 Mar 14;20(1):217. Epub 2019 Mar 14.

Department of Computer Science, University of Miami, 1365 Memorial Drive, Coral Gables, FL, 33124-4245, USA.

Background: Topologically associating domains (TADs) are considered the structural and functional units of the genome. However, there is a lack of an integrated resource for TADs in the literature where researchers can obtain family classifications and detailed information about TADs.

Results: We built an online knowledge base TADKB integrating knowledge for TADs in eleven cell types of human and mouse. Read More

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http://dx.doi.org/10.1186/s12864-019-5551-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419456PMC

A detection of benzimidazole resistance-associated SNPs in the isotype-1 β-tubulin gene in Haemonchus contortus from wild blue sheep (Pseudois nayaur) sympatric with sheep in Helan Mountains, China.

BMC Vet Res 2019 Mar 12;15(1):89. Epub 2019 Mar 12.

College of Wildlife Resources, Northeast Forestry University, Harbin, China.

Background: Benzimidazole (BZ) resistance is an increasingly serious problem due to the excessive use of this anthelmintic for controlling Haemonchus contortus, which is one of the major gastrointestinal nematodes infecting small ruminants worldwide. Three known single nucleotide polymorphisms (SNPs), F167Y (TAC), E198A (GCA) and F200Y (TAC), in the isotype-1 β-tubulin gene of H. contortus are associated with BZ resistance. Read More

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http://dx.doi.org/10.1186/s12917-019-1838-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416841PMC
March 2019
1 Read

Identification and antimicrobial susceptibility profile of Escherichia coli isolated from backyard chicken in and around ambo, Central Ethiopia.

BMC Vet Res 2019 Mar 11;15(1):85. Epub 2019 Mar 11.

School of Veterinary Medicine, Wolaita Sodo University, P O Box 138, Sodo, Ethiopia.

Background: Escherichia coli is bacteria that exist as commensal in the intestine of animals and humans, but pathogenic strains cause disease in chickens. The development of antimicrobial resistance in E. coli is one of major concern worldwide. Read More

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http://dx.doi.org/10.1186/s12917-019-1830-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417126PMC
March 2019
1 Read

Cancer patients' use of complementary and alternative medicine in Sweden: a cross-sectional study.

BMC Complement Altern Med 2019 Mar 13;19(1):62. Epub 2019 Mar 13.

Regional Cancer Center Stockholm Gotland, Box 6909, 102 39, Stockholm, Sweden.

Background: Access to and advice on Complementary and Alternative Medicine (CAM) are uncommon within Swedish conventional cancer care and little is known about cancer patients' own use of CAM. The aim of this cross-sectional study was to explore Swedish cancer patients´ patterns of CAM use, their experiences and preferences.

Methods: Questionnaires were distributed consecutively to 1297 cancer patients at a university hospital's out-patient oncology units. Read More

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http://dx.doi.org/10.1186/s12906-019-2452-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417272PMC

Effect of fractioning on antibacterial activity of n-butanol fraction from Enantia chlorantha stem bark methanol extract.

BMC Complement Altern Med 2019 Mar 11;19(1):56. Epub 2019 Mar 11.

Faculty of Sciences, University of Yaoundé I, PO, Box 812, Yaoundé, Cameroon.

Background: Enantia chlorantha is a plant belonging to Annonaceae Family. The Barks and leaves are used traditionally to treat infectious diseases. Earlier studies highlighted the antibacterial activity of stem barks methanol extract. Read More

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http://dx.doi.org/10.1186/s12906-019-2459-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416886PMC
March 2019
1 Read
2.020 Impact Factor

Association between glycosylated hemoglobin A1c and bone biochemical markers in type 2 diabetic postmenopausal women: a cross-sectional study.

BMC Endocr Disord 2019 Mar 12;19(1):31. Epub 2019 Mar 12.

Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Anti-inflammatory and Immune Medicine innovation team, Hefei, 230032, China.

Background: type 2 diabetes mellitus (T2DM) is a complicated disease that can affect bone health, but the change in bone biochemical markers caused by T2DM was controversial, so the aim of this study was to investigate whether there was a discrepancy in the levels of bone biochemical markers between postmenopausal women with T2DM and non-diabetic women and to explore the relationship between the level of glycosylated hemoglobin A1c (HbA1c) and bone biochemical markers in these subjects.

Methods: A total of 237 type 2 diabetic postmenopausal women visiting the First Affiliated Hospital of Anhui Medical University from January 2017 to October 2018 and 93 healthy postmenopausal women were retrospectively enrolled. The differences in the levels of bone biochemical markers between patients and controls were analyzed by one-way ANOVA or chi-square test. Read More

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http://dx.doi.org/10.1186/s12902-019-0357-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416956PMC
March 2019
1 Read

Basal and dynamics mRNA expression of muscular HSP108, HSP90, HSF-1 and HSF-2 in thermally manipulated broilers during embryogenesis.

BMC Vet Res 2019 Mar 8;15(1):83. Epub 2019 Mar 8.

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University, P.O. Box 400, Al-Hufof, 31982, Saudi Arabia.

Background: Limited data are available about the kinetics of mRNA expressions of Heat shock proteins (HSPs) and heat shock factors (HSFs) in the thermally manipulated (TM) broiler chicks during acute heat stress. Therefore, this study aimed to investigate effects of thermal manipulation (TM) of broiler chicken during embryonic days (ED) 12-18 on the basal and dynamics mRNA expression of heat shock proteins (HSP108 and HSP90) and heat shock factors (HSF-1 and HSF-2) in the muscle tissue during late embryogenesis, first week of life and during heat stress (HS) on post-hatch days 14 and 28. One thousand and five hundred fertile Ross 315 broiler eggs were randomly allocated to five groups: control group (37. Read More

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http://dx.doi.org/10.1186/s12917-019-1827-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408791PMC
March 2019
3 Reads

Effects of concentration of amyloid β (Aβ) on viability of cultured retinal pigment epithelial cells.

BMC Ophthalmol 2019 Mar 8;19(1):70. Epub 2019 Mar 8.

Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8522, Japan.

Background: Amyloid beta (Aβ) is a constituent of drusen that is a common sign of age-related macular degeneration (AMD). The purpose of this study was to investigate the effect of Aβ on human retinal pigment epithelial (RPE) cells in culture.

Methods: Cells from a human RPE cell line (ARPE-19) were exposed to 0 to 25 μM of Aβ 1-40 for 48 h, and the number of living cells was determined by WST-8 cleavage. Read More

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http://dx.doi.org/10.1186/s12886-019-1076-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408759PMC

Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model.

BMC Cancer 2019 Mar 7;19(1):205. Epub 2019 Mar 7.

Department of Medicine, Section of Hematology & Medical Oncology, Tulane University School of Medicine, New Orleans, LA, USA.

Background: Triple-negative breast cancer (TNBC) represents an aggressive subtype with limited therapeutic options. Experimental preclinical models that recapitulate their tumors of origin can accelerate target identification, thereby potentially improving therapeutic efficacy. Patient-derived xenografts (PDXs), due to their genomic and transcriptomic fidelity to the tumors from which they are derived, are poised to improve the preclinical testing of drug-target combinations in translational models. Read More

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http://dx.doi.org/10.1186/s12885-019-5401-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407287PMC
March 2019
3.362 Impact Factor

The MEOPAeDent trial protocol-an observational study of the Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) effects in paediatric dentistry.

BMC Oral Health 2019 Mar 7;19(1):42. Epub 2019 Mar 7.

Pharmacology Department - Addictovigilance, CHU Nantes, Nantes, France.

Background: Many studies were conducted to assess the benefit/risk ratio of EMONO (Equimolar Mixture of Oxygen and Nitrous Oxide) in France before it was authorized for use outside the hospital setting in 2009. The main objective of this project is to evaluate the effects sought and felt by children when EMONO is used in paediatric dentistry. The secondary objectives are to (i) evaluate the appreciation of EMONO by the children, (ii) characterize children who experience both analgesia and anxiolysis, (iii) evaluate children's appetite for EMONO and characterize children with a high appetite and (iv) evaluate the impact of the difference in practice among the French dental service university hospitals on anxiety. Read More

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http://dx.doi.org/10.1186/s12903-019-0732-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407269PMC
March 2019
1 Read

Transcriptomic analysis reveals the regulatory module of apple (Malus × domestica) floral transition in response to 6-BA.

BMC Plant Biol 2019 Mar 6;19(1):93. Epub 2019 Mar 6.

Department of Horticulture College, Northwest Agriculture & Forestry University, Yangling, 712100, China.

Background: Insufficient production of flower buds is an intractable problem in 'Fuji' apple orchards. Although cytokinin (CK) promotes flower bud formation in apple trees, little is known about the mechanisms regulating this phenomenon.

Results: In the present study, high-throughput RNA sequencing (RNA-Seq) of 'Nagafu No. Read More

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http://dx.doi.org/10.1186/s12870-019-1695-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402183PMC
March 2019
2 Reads

Effects of unaltered and bioconverted mulberry leaf extracts on cellular glucose uptake and antidiabetic action in animals.

BMC Complement Altern Med 2019 Mar 6;19(1):55. Epub 2019 Mar 6.

Department of Pharmacology, Chungnam National University College of Pharmacy, 99 Daehak-ro (St.), Yuseong-gu, Daejeon, 34134, Republic of Korea.

Background: Mulberry is a Korean medicinal herb that shows effective prevention and treatment of obesity and diabetes. Bioconversion is the process of producing active ingredients from natural products using microorganisms or enzymes.

Methods: In this study, we prepared bioconverted mulberry leaf extract (BMLE) with Viscozyme L, which we tested in insulin-sensitive cells (i. Read More

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http://dx.doi.org/10.1186/s12906-019-2460-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404318PMC
March 2019
1 Read

Effect of green tea and mulberry leaf powders on the gut microbiota of chicken.

BMC Vet Res 2019 Mar 6;15(1):77. Epub 2019 Mar 6.

School of Life Science, Huizhou University, Huizhou, 516007, China.

Background: The gut microbiota is closely correlated with host health and is strongly influenced by food composition. Chinese herbs are usually used as natural feed additives in livestock production. Therefore, the present study assessed the influence of diet supplementation with green tea and mulberry leaf powders on the chicken gut microbiota. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
Publisher Site
http://dx.doi.org/10.1186/s12917-019-1822-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404333PMC
March 2019
7 Reads