1,904 results match your criteria Blue Nevi

Chrysiasis: Gold Aggregates Around a Nevus and Osteoma Cutis.

Am J Dermatopathol 2021 May 11. Epub 2021 May 11.

Department of Dermatology, Keck School of Medicine at the University of Southern California, Los Angeles, CA; Department of Pathology, State University of New York Upstate Medical University, Syracuse, NY; Touro University Nevada, Henderson, NV; and Rose Salter Medical Research Foundation, Newport Beach, CA.

Abstract: Parenteral gold has historically been used to treat several conditions, including rheumatoid arthritis. Gold administration leads to a variety of cutaneous reactions, including chrysiasis, which is a permanent blue-grey hyperpigmentation of the skin due to dermal gold deposition. In this report, we describe the case of a patient who received parenteral gold injections 22 years before the onset of her chrysiasis for the treatment of rheumatoid arthritis. Read More

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Histopathologic classification and prognostic factors of melanoma: a 2020 update.

Mattheos Bobos

Ital J Dermatol Venerol 2021 May 13. Epub 2021 May 13.

Department of Biomedical Sciences, School of Health Sciences, Alexandrian Campus, International Hellenic University, Thessaloniki, Greece -

Despite the rapid recent advances in molecular analysis of tumors, which allow large-scale and high-resolution genomics, the "gold standard" for melanoma diagnosis continues to be histopathology, in conjunction with clinical characteristics and sometimes with important support of immunohistochemistry. Observations, where postulated that cutaneous melanomas may arise through two distinct pathways, discoveries such as that BRAFV600E mutations were mostly common in melanomas on sun-exposed skin with little solar elastosis and seminal works for melanoma progression and evolution set the groundwork for the new WHO Classification of Melanoma; a classification of melanoma that not only encompasses histologic but also clinical, epidemiologic, and genetic characteristics. The melanomas were divided into those etiologically related to sun exposure and those that are not, based on their mutational signatures, anatomic site, and epidemiology. Read More

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Expression of Oncogene in Benign, Malignant and Borderline Melanocytic Tumors-Unmasking the Wolf in Sheep's Clothing?

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Department of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, D-66421 Homburg, Germany.

oncogene located at chromosomal region 3q26 encodes for a transmembrane protein of the endoplasmic reticulum (ER) and is expressed at high levels in numerous human malignancies. overexpression has been associated with worse prognosis and high risk for lymphatic and distant metastases in head and neck cancer, cervical cancer, hepatocellular cancer, and lung cancer. However, its role in the development and tumor biology of melanocytic lesions has not been investigated so far. Read More

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A Case Report on the Dermoscopic Features of Spark's Nevus.

Ann Dermatol 2020 Jun 24;32(3):233-236. Epub 2020 Apr 24.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Spark's nevus is a compound word composed of Spitz nevus and Clark's nevus. It is one of the combined melanocytic nevi which is more common in female and usually presents as a sharp circumscribed hyperpigmented macule on the lower extremities. On histopathologic findings, both cytologic features of Spitz nevus characterized as large spindle or epithelioid melanocytes containing large nuclei with abundant cytoplasm, and architecture of Clark's nevus characterized as elongation of rete ridges, bridging of the nests, concentric and lamellar fibrosis can be seen. Read More

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Laryngeal Obstruction due to Blue Rubber Bleb Nevus Syndrome.

Ear Nose Throat J 2021 Apr 28:1455613211013078. Epub 2021 Apr 28.

Department of Oral and Maxillofacial Sciences, 9311Sapienza University of Rome, Roma, Italy.

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Treatment strategies for inferior vena cava aneurysms.

J Vasc Surg Venous Lymphat Disord 2021 Apr 17. Epub 2021 Apr 17.

Department of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address:

Objective: An inferior vena cava (IVC) aneurysm is a rare but potentially life-threatening entity. We successfully embolized an IVC aneurysm in a patient with history of blue rubber bleb nevus syndrome, a rare syndrome with multiple venous malformations. This new case was added to a literature review of previously reported cases, to analyze the management algorithm. Read More

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Unilateral clubbing-like digital thickening as a clinical manifestation of low-flow vascular malformations: a series of 13 cases.

Int J Dermatol 2021 Apr 13. Epub 2021 Apr 13.

Department of Dermatology, Hospital Universitario Virgen del Rocio, Sevilla, Spain.

Background: Digital clubbing is a well-known clinical sign characterized by thickening of the distal phalanges of the fingers and toes. Unilateral clubbing occurs less frequently. A previous report showed for the first time two cases of unilateral clubbing as a clinical manifestation of lower limb venous malformation. Read More

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The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.

Acta Dermatovenerol Croat 2020 Dec;28(7):236-237

Prof. Luca Roncati, MD, DMLS, PhD , Polyclinic Hospital, Largo del Pozzo 71 - 41124 , Modena (MO), Italy;

Malignant melanoma (M) can be defined, quite simply, as a malignant neoplasm derived from melanocytes; however, there is great histological and, consequently, clinical variability from case to case (1). In order to try to overcome this intrinsic difficulty, various classification systems have been proposed over the years; as part of this effort, the World Health Organization (WHO) introduced its famous classification about half a century ago (2). Currently, the International Classification of Diseases for Oncology (ICD-O), provided by the WHO International Agency for Research on Cancer (IARC), distinguishes the in situ forms from invasive ones, recognizing four main morphological subtypes: nodular M, superficial spreading M, lentigo maligna M, and acral lentiginous M (3). Read More

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December 2020

Blue rubber bleb nevus syndrome associated with tuberous sclerosis complex and CNS involvement.

Neurosciences (Riyadh) 2021 Apr;26(2):207-211

From the Department of Neuroscience, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder that is characterized by multiple dome-shaped cutaneous venous malformations on the skin and visceral organs. Typical extra-cutaneous lesions have the appearance of blueish nipple-shaped nodules that can easily compress and refill. We described a rare case of a 23-year-old female with BRBNS and tuberous sclerosis complex (TSC) that presented with central nervous system (CNS) involvement including unprovoked focal impaired awareness seizure. Read More

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Giant Congenital Blue Nevus Presenting as Cutis Verticis Gyrata: A Case Report and Review of the Literature.

Ann Otol Rhinol Laryngol 2021 Apr 3:34894211007236. Epub 2021 Apr 3.

Department of Plastic Surgery, University of Kansas Medical Center, Kansas City, KS, USA.

Objectives: Cerebriform intradermal nevus and giant congenital blue nevi are rarely reported melanocytic nevi with clinical and histopathologic similarities. Both are known to produce cutis verticis gyrata. We report a significantly large occipital scalp congenital blue nevus with secondary cutis verticis gyrata. Read More

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Comments on "Subungual blue nevus" by Webster TG et al.

J Cutan Pathol 2021 Apr 4. Epub 2021 Apr 4.

Department of Dermatology, St Pierre, Brugmann and Children's University Hospitals, Université Libre de Bruxelles, Bruxelles, Belgium.

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Melanocytic lesions with blue nevus-like (dendritic) morphology: an update with emphasis on histopathologic, immunophenotypic and molecular features.

Histopathology 2021 Mar 27. Epub 2021 Mar 27.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston.

An accurate diagnosis of melanocytic lesions requires a thorough histopathologic evaluation accompanied by appropriate correlation with clinical examination findings. Although most melanocytic lesions can readily be classified as one of the defined diagnostic entities using well-established diagnostic criteria, a subset of melanocytic lesions, particularly those with blue nevus-like (pigmented dendritic) morphology, have notoriously been an enduring challenge for pathologists. These lesions are rare and often demonstrate histologic ambiguities with features of both benignity and malignancy, thereby making accurate risk assessment and prediction of their biological behaviors difficult on histologic grounds alone. Read More

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Unexpected high fluorine-18 fluorodeoxyglucose uptake on positron emission tomography/computed tomography of a benign cellular blue nevus.

Indian J Dermatol Venereol Leprol 2021 Mar-Apr;87(2):265-267

Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

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January 2020

Endoscopic treatment of blue rubber bleb nevus syndrome in a 4-year-old girl with long-term follow-up: A case report.

World J Gastrointest Endosc 2021 Mar;13(3):90-96

Department of Pediatric Surgery, Republican Scientific and Practical Center of Pediatric Surgery, Minsk 220013, Belarus.

Background: Blue rubber bleb nevus syndrome (BRBNS) is a rare vascular disease, difficult to diagnose and choose a treatment method, especially in young children. There are several limiting factors to the use of enteroscopy for diagnostics and treatment in pediatric patients, in general. The literature on BRBNS cases is limited and presents various therapeutic approaches. Read More

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Perineuriomatous nevi: A series of eight cases highlighting unifying pathologic features to avoid misdiagnosis.

J Cutan Pathol 2021 Mar 21. Epub 2021 Mar 21.

Department of Pathology, Cleveland Clinic, Cleveland, Ohio, USA.

Background: Perineuriomatous nevi are rare and diagnostically problematic. We report a series of eight perineuriomatous nevi to highlight the diagnostic features.

Methods: Cases were retrospectively reviewed and characterized. Read More

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A narrative review of the role of sirolimus in the treatment of congenital vascular malformations.

J Vasc Surg Venous Lymphat Disord 2021 Mar 15. Epub 2021 Mar 15.

Department of Pediatric Hemato-Oncology, University Hospitals Leuven, Leuven, Belgium; Catholic University Leuven, Center for Molecular and Vascular Biology, Leuven, Belgium. Electronic address:

Objective: Vascular malformations arise from defects in the morphologic development of the vascular system and can have an impact on quality of life and/or lead to severe complications. To date, vascular malformations are frequently managed by invasive techniques, after which recurrence is common. Sirolimus, a downstream inhibitor of the phosphatidylinositol 3 kinase/AKT pathway and best known for its immunosuppressive effect, has been used off-label for lesions for which approved therapies were associated with unsatisfactory results or recurrence. Read More

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Blue rubber bleb nevus syndrome: an unusual cause of intestinal bleeding in the elderly.

Endoscopy 2021 Mar 5. Epub 2021 Mar 5.

Department of Digestive Surgery, Aix Marseille Université, APHM, Timone University Hospital, Marseille, France.

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Distribution Patterns (7B Rule) and Characteristics of Large Congenital Melanocytic Nevi: A Retrospective Cohort Study in China.

Front Med (Lausanne) 2021 19;8:637857. Epub 2021 Feb 19.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Large congenital melanocytic nevus has a high risk of malignancy. However, few studies have summarized its characteristics, treatments, outcomes and malignancy incidence in Chinese patients. This paper reviews a retrospective cohort study evaluating 1,171 patients from Shanghai Ninth People's Hospital between 1 January 1989 and 31 August 2019 using electronic medical records and phone calls to collect clinical and pathological data in which 133 patients were diagnosed with a large congenital melanocytic nevus. Read More

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February 2021

[Diffuse angiomatous lesions].

Rev Med Interne 2021 Mar 1. Epub 2021 Mar 1.

Service de dermatologie et vénérologie, CHU Ibn Rochd Casablanca, Maroc.

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Gastrointestinal: Small intestinal blue rubber bleb nevus syndrome.

J Gastroenterol Hepatol 2021 Feb 18. Epub 2021 Feb 18.

Department of Gastroenterology, Macquarie University Hospital, Sydney, New South Wales, Australia.

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February 2021

Atypical Cellular Blue Nevus With Necrosis Mimicking Melanoma Ex-Blue Nevus.

Am J Dermatopathol 2021 May;43(5):e61-e64

Department of Pathology and Laboratory Medicine, Summa Health System, Akron City, OH; and.

Abstract: Histologic distinction between melanoma ex-blue nevus and cellular blue nevus (CBN) can often be difficult, but features supporting melanoma include infiltrative growth pattern, frequent mitoses, cytologic atypia and pleomorphism, cell crowding, and tumor necrosis. Unfortunately, these features are not constantly dependable and frequently borderline lesions exist, so-called atypical CBN, which lack explicit malignant features. Furthermore, some CBN and atypical CBN show an assortment of features, which may lead to their misdiagnosis as melanoma, but to date necrosis is generally absent. Read More

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Both Age and Disease Duration are Associated with Clinical Phenotype of Hori's Nevus in Chinese: A Retrospective Analysis of 497 Cases.

Clin Cosmet Investig Dermatol 2021 18;14:65-71. Epub 2021 Jan 18.

Aesthetic Department, Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong 510091, People's Republic of China.

Background: Hori's nevus is a common pigmented disorder on the face, preferentially in females. The clinical features have not been well characterized.

Aim: To characterize the clinical features of Hori's nevus in Chinese adults. Read More

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January 2021

Super-high magnification dermoscopy can add information for the differential diagnosis between melanoma and atypical nevi.

Clin Exp Dermatol 2021 Jan 23. Epub 2021 Jan 23.

Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne Cedex, France.

Background: Dermoscopy is the most used non-invasive imaging technique for the clinical diagnosis of melanoma (MM). Super-high magnification dermoscopy at 400x magnification (D400) has been recently developed and can reveal additional features compared to traditional dermoscopy, up to the identification of single melanocytes in the skin.

Objectives: To evaluate which structures could be viewed at D400 and to compare them in atypical nevi and MMs. Read More

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January 2021

Photoablative cosmetic iridoplasty: effective, safe, and predictable-eye color change in 1176 eyes.

Int Ophthalmol 2021 Apr 23;41(4):1381-1393. Epub 2021 Jan 23.

Eyecos Clinic, Tuset, 23-25, 08006, Barcelona, Spain.

Purpose: To evaluate photoablative cosmetic iridoplasty (PCI), and its efficacy, safety, predictability, and satisfaction with the 532 nm Crystal Q-switched Nd: Yag laser, with 3-4 ns pulses, for depigmentation of the anterior epithelium of the iris in cases of heterochromia, nevus, or cosmetic indications (eye color change).

Design: Prospective clinical study on efficacy, safety, predictability, and satisfaction.

Method: The selection of patients was carried out in healthy individuals, over 18 years of age, with iris heterochromia (congenital-7% or acquired, secondary to topical medication-1%, trauma-0. Read More

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Recurrent cardiac and skin myxomas along with acromegaly: A case report of carney complex.

ARYA Atheroscler 2020 May;16(3):146-150

Associate Professor, Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Carney complex (CNC) is an uncommon multisystem endocrine disorder with significant variability of clinical manifestations including mucocutaneous involvement (pigmented lesions, myxomas, blue nevi, etc.), endocrine tumors (adrenal, pituitary, thyroid glands, or testicles), and non-endocrine tumors [cardiac myxomas, psammomatous melanotic schwannomas (PMS), breast myxomas as well as ductal adenomas, and osteochondromyxomas]. To our knowledge, this is the second report of CNC in Iran, presenting with typical manifestations. Read More

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ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.

Virchows Arch 2021 Jan 12. Epub 2021 Jan 12.

Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy.

The recent WHO classification of skin tumors has underscored the importance of acknowledging intermediate grade melanocytic proliferations. A multistep acquisition of oncogenic events drives the progressive transformation of nevi into melanomas. The various pathways described are modulated by the initial oncogenic drivers that define the common, blue, and Spitz nevi groups. Read More

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January 2021

Endoscopic patterns of the blebs in blue rubber bleb nevus syndrome.

Gastrointest Endosc 2021 May 6;93(5):1181-1182. Epub 2021 Jan 6.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, USA.

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Efficacy and Safety of Sirolimus for Blue Rubber Bleb Nevus Syndrome: A Prospective Study.

Am J Gastroenterol 2021 05;116(5):1044-1052

State Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Introduction: Blue rubber bleb nevus syndrome (BRBNS) is a rare systemic venous malformation (VM) disease. The characteristic gastrointestinal (GI) bleeding from multiple VM lesions causes severe chronic anemia which renders most patients depend on lifelong blood transfusion and frequent endoscopic treatment with dismayed outcomes. Although recent case reports suggest that oral sirolimus (rapamycin) is effective, a comprehensive evaluation of its efficacy and safety is in need. Read More

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Long-term sirolimus treatment in blue rubber bleb nevus syndrome: Case report and review of the literature.

Pediatr Dermatol 2021 Mar 31;38(2):464-468. Epub 2020 Dec 31.

Department of Paediatric Dermatology, Catholic Children's Hospital Wilhelmstift, Hamburg, Germany.

Blue rubber bleb nevus syndrome is a rare vascular syndrome characterized by continuous eruption of vascular nodules in the skin, mucous membranes, and solid organs due to somatic activating mutations of the angiopoietin receptor TEK gene. It may be complicated by acute life-threatening hemorrhage and localized intravascular coagulation. We report an 11-year-old girl with complicated blue rubber bleb nevus syndrome treated with sirolimus since the age of 2. Read More

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Influence of germline genetic variants on dermoscopic features of melanoma.

Pigment Cell Melanoma Res 2021 May 31;34(3):618-628. Epub 2021 Jan 31.

Melanoma Unit, Dermatology Department, Hospital Clínic & IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain.

Nevus count is highly determined by inherited variants and has been associated with the origin of melanoma. De novo melanomas (DNMMs) are more prevalent in patients with a low nevus count and have distinctive dermoscopic features than nevus-associated melanomas. We evaluated the impact of nine single nucleotide polymorphisms (SNPs) of MTAP (rs10811629, rs2218220, rs7023329 and rs751173), PLA2G6 (rs132985 and rs2284063), IRF4 (rs12203592), and PAX3 (rs10180903 and rs7600206) genes associated with nevus count and melanoma susceptibility, and the MC1R variants on dermoscopic features of 371 melanomas from 310 patients. Read More

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