1,752 results match your criteria Blue Nevi


Angiosarcoma of the Liver: Clinicopathologic Features and Morphologic Patterns.

Am J Surg Pathol 2019 May;43(5):581-590

Division of Anatomic Pathology, Mayo Clinic, Rochester, MN.

Angiosarcoma is a rare malignant neoplasm of the liver. The various morphologic patterns seen with angiosarcomas of the liver have not been systematically studied and their recognition remains a major diagnostic challenge. In order to provide more comprehensive data on the morphologic patterns, angiosarcomas that had been diagnosed between 1996 and 2016 at a large medical referral center were reviewed. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001228DOI Listing
May 2019
4 Reads

A Man with Juvenile Nasopharyngeal Angiofibroma, Vestibular Schwannoma, Cleft Lip and Cleft Palate, and Various Nevi: Case Report and Review.

Cureus 2018 Sep 14;10(9):e3304. Epub 2018 Sep 14.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Juvenile nasopharyngeal angiofibroma is a vascular tumor that typically occurs in men. Vestibular schwannoma (acoustic neuroma) is a tumor affecting the vestibulocochlear nerve. A 38-year-old man with various pigmented lesions and history of juvenile nasopharyngeal angiofibroma, vestibular schwannoma, and cleft lip and cleft palate is described. Read More

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http://dx.doi.org/10.7759/cureus.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417465PMC
September 2018
1 Read

Clinical and Histopathologic Characteristics of Melanocytic Lesions on the Volar Skin Without Typical Dermoscopic Patterns.

JAMA Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

Importance: It is challenging to differentiate melanoma from melanocytic nevus on the volar skin in the absence of typical dermoscopic patterns.

Objective: To identify the frequency and clinical and dermoscopic characteristics of melanocytic lesions on the volar skin not displaying a parallel furrow pattern, lattice-like pattern, fibrillar pattern, or parallel ridge pattern on results of dermoscopy.

Design, Setting, And Participants: In this retrospective cohort study, a total of 504 melanocytic lesions on the volar skin were evaluated in the Shinshu University Hospital department of dermatology between January 1, 2000, and December 31, 2012. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.5926DOI Listing
March 2019
1 Read

Painful tumors of the skin: "CALM HOG FLED PEN AND GETS BACK".

Clin Cosmet Investig Dermatol 2019 13;12:123-132. Epub 2019 Feb 13.

Compass Dermatopathology, San Diego, CA, USA.

Painful tumors of the skin present as dermal or subcutaneous nodules. They can originate from several sources: adipose tissue, cartilage degeneration, deposition of bone or calcium, eccrine glands, fibrous tissue, infiltration of benign (endometrium) or malignant (metastatic neoplasm) tissue, muscle, nerve, or vascular structures. Although pathologic evaluation of the lesion is necessary to determine the diagnosis, it is possible to make a reasonable differential diagnosis based on knowledge of prior tumors that have appeared as tender lesions. Read More

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https://www.dovepress.com/painful-tumors-of-the-skin-calm-ho
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http://dx.doi.org/10.2147/CCID.S193359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386355PMC
February 2019
6 Reads

β-Catenin nuclear expression discriminates deep penetrating nevi from other cutaneous melanocytic tumors.

Virchows Arch 2019 Feb 12. Epub 2019 Feb 12.

Departement de Biopathologie, Centre Léon Bérard, 28, rue Laennec, 69008, Lyon, France.

Recent advances in genomics have improved the molecular classification of cutaneous melanocytic tumors. Among them, deep penetrating nevi (DPN) and plexiform nevi have been linked to joint activation of the MAP kinase and dysregulation of the β-catenin pathways. Immunohistochemical studies have confirmed cytoplasmic and nuclear expression of β-catenin and its downstream effector cyclin D1 in these tumors. Read More

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http://dx.doi.org/10.1007/s00428-019-02533-9DOI Listing
February 2019
16 Reads

Blue rubber bleb nevus syndrome: endoscopic treatment with sclerotherapy during double-balloon enteroscopy in a 9-year-old boy.

Endoscopy 2019 Feb 12. Epub 2019 Feb 12.

Department of Endoscopy and Gastroenterology, Pavillon L, Edouard Herriot Hospital, Lyon, France.

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http://dx.doi.org/10.1055/a-0840-3214DOI Listing
February 2019
18 Reads

Magnetically Controlled Capsule Endoscopy in Children: A Single Center, Retrospective Cohort Study.

J Pediatr Gastroenterol Nutr 2019 Feb 7. Epub 2019 Feb 7.

Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China.

Objective: Capsule endoscopy (CE) is a noninvasive diagnostic tool for the digestive tract. We aim to investigate the feasibility and safety of newly-developed magnetically controlled capsule endoscopy (MCE) in children.

Methods: A total of 129 children who underwent MCE in Shanghai Children's Hospital were retrospectively recruited between March 2016 and August 2018. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002292DOI Listing
February 2019
15 Reads

Photoacoustic imaging as an innovative technique for the exploration of Blue Rubber Bleb Nevus.

Br J Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Institute for Advanced Biosciences, Univ. of Grenoble Alpes, INSERM U1209 and CNRS UMR5309, 38000, Grenoble, France.

Blue rubber bleb nevus syndrome (BRBN, Bean syndrome) is a rare vascular malformation (VM) characterized by multiple cutaneous and mucous venous defects disseminated throughout the body. An infringement of mucous membranes is possible with potential complications as anemia or hemorrhage. Photoacoustic imaging (PAI) is an emerging technology combining the most compelling features of optical imaging and ultrasound, providing both high optical contrast and high ultrasound resolution at depth in living organisms . Read More

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http://doi.wiley.com/10.1111/bjd.17765
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http://dx.doi.org/10.1111/bjd.17765DOI Listing
February 2019
7 Reads

Variables that predict response of nevus of ota to lasers.

J Cosmet Dermatol 2019 Apr 5;18(2):464-468. Epub 2019 Feb 5.

Department of Dermatology, DR RMLH, PGIMER, New Delhi, India.

Nevus of ota is a dermal melanocytosis common among Asian patients, mottled, blue-gray macule that is usually located unilaterally within the distribution of the first and second branches of the trigeminal nerve and almost always responds well to treatment with Q-switched lasers (eg, ruby, alexandrite, and Nd: YAG). In spite of the plethora of science behind laser-tissue interactions, the objective evaluation of nevus of ota response to laser is not on firm footing and most studies report subjective percentile scoring improvement. A knowledge of the variations in morphology of nevus of ota can help predict an optimal dose response and help to counsel patients appropriately. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12875
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http://dx.doi.org/10.1111/jocd.12875DOI Listing
April 2019
3 Reads

A cellular blue nevus with pigmented epithelioid melanocytoma-like pattern on the ipsilateral upper arm associated with a congenital plaque-type blue nevus on the hand.

J Cutan Pathol 2019 May 28;46(5):383-388. Epub 2019 Mar 28.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

A 36-year-old man presented with a subcutaneous nodule on the right upper arm. A small nodule had developed 8 years earlier, and grew in size, accompanied by a tingling sensation and numbness. In addition, he had a bluish irregular patch on the right hand since birth, which crossed from the palm to the dorsal hand. Read More

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http://dx.doi.org/10.1111/cup.13435DOI Listing
May 2019
1 Read

Glomuvenous malformations in a young man.

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

University of Mississippi Medical Center School of Medicine, Department of Dermatology, and Department of Pathology, Jackson, Mississippi.

A young man presented with blue nodules on the trunk, face, and extremities that gradually increased in number and size. His mother had similar lesions. Initially, blue rubber bleb nevus syndrome was suspected, but histological findings confirmed the diagnosis of hereditary glomuvenous malformations. Read More

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October 2018
1 Read

Hyperspectral imaging in automated digital dermoscopy screening for melanoma.

Lasers Surg Med 2019 Mar 17;51(3):214-222. Epub 2019 Jan 17.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York.

Objectives: Early melanoma detection decreases morbidity and mortality. Early detection classically involves dermoscopy to identify suspicious lesions for which biopsy is indicated. Biopsy and histological examination then diagnose benign nevi, atypical nevi, or cancerous growths. Read More

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http://doi.wiley.com/10.1002/lsm.23055
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http://dx.doi.org/10.1002/lsm.23055DOI Listing
March 2019
42 Reads

Gastrointestinal: Endoscopic injection sclerotherapy for duodenal vascular malformation in blue rubber bleb nevus syndrome.

J Gastroenterol Hepatol 2019 Jan 14. Epub 2019 Jan 14.

Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.

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http://dx.doi.org/10.1111/jgh.14590DOI Listing
January 2019
2 Reads

Use of Targeted Next-Generation Sequencing to Identify Activating Hot Spot Mutations in Cherry Angiomas.

JAMA Dermatol 2019 Feb;155(2):211-215

Department of Dermatology, Massachusetts General Hospital, Boston.

Importance: Shared gene variants in benign-malignant process pairs, such as BRAF mutations common to benign nevi and melanoma, are associated with differing phenotypic manifestations. Study of gene mechanisms underlying cherry angioma may uncover previously unknown disease relationships.

Objective: To identify somatic mutations present in cherry angioma specimens by using targeted next-generation sequencing. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.4231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440195PMC
February 2019
30 Reads

Blue Rubber Bleb Nevus Syndrome with Long-Term Follow-Up: A Case Report and Review of the Literature.

Case Rep Gastrointest Med 2018 25;2018:8087659. Epub 2018 Nov 25.

Department of Pediatric Surgery, Shizuoka Children's Hospital, 860 Urushiyama, Aoi-ku, Shizuoka 420-8660, Shizuoka, Japan.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disease in which venous malformations (VMs) involve any body organ, most commonly the skin and the gastrointestinal (GI) tract. Treatment of BRBNS aims at preserving the GI tract as much as possible. Although there are several dozen case reports about BRBNS that describe short-term clinical courses, a few provide an account of long-term clinical course. Read More

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http://dx.doi.org/10.1155/2018/8087659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286777PMC
November 2018
2 Reads

Orbital Hemangioma in Bean Syndrome: The Lure of the Red Herring.

World Neurosurg 2019 Mar 18;123:272-280. Epub 2018 Dec 18.

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Bean syndrome (BS) is a rare congenital low-flow angiomatosis affecting multiple organ systems. About 200 cases with heterogeneous clinical presentation have been reported worldwide. The exact etiopathology is still not known. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.257DOI Listing
March 2019
1 Read
2.417 Impact Factor

Blue Rubber Bleb Nevus Syndrome: A Possible Cause for Growth Retardation and Pubertal Delay.

Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: The aim of this paper was to describe a rare case of blue rubber bleb nevus (BRBNS) with growth retardation and pubertal delay.

Clinical Presentation And Intervention: A 16-year-old boy with severe iron deficiency anemia was diagnosed with BRBNS, showing growth retardation and pubertal delay simultaneously. The patient was treated conservatively with intravenous iron therapy, and his puberty advanced gradually. Read More

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http://dx.doi.org/10.1159/000496105DOI Listing
December 2018
15 Reads

Dermoscopic evaluation of melanocytic nevi changes after photo-epilation techniques: a prospective study.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Clinic - Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Background: The clinical and dermoscopic changes of melanocytic nevi under the effects of photo-epilation are poorly known.

Objective: Prospective study on clinical and dermatoscopic effects of photoe-pilation on melanocytic nevi.

Methods: Eighteen patients exposed to photo-epilation gave consent to a follow-up programme from 2008 to 2017 at the Videodermatoscopic Office of the Dermatology Clinic of Cagliari (Italy), with clinical and dermoscopic assessment. Read More

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http://dx.doi.org/10.1111/jdv.15388DOI Listing
December 2018
6 Reads

A diagnostically-challenging case of melanoma ex blue nevus with comprehensive molecular analysis, including the 23-gene expression signature (myPath melanoma).

J Cutan Pathol 2019 Mar 26;46(3):226-230. Epub 2018 Dec 26.

Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hybridization were used to arrive at the correct diagnosis. Read More

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http://doi.wiley.com/10.1111/cup.13400
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http://dx.doi.org/10.1111/cup.13400DOI Listing
March 2019
14 Reads

Impact of clinical and personal data in the dermoscopic differentiation between early melanoma and atypical nevi.

Dermatol Pract Concept 2018 Oct 31;8(4):324-327. Epub 2018 Oct 31.

Dermatology Division, Department of Medical, Surgical and NeuroSciences, University of Siena, Siena, Italy.

Background: Differential diagnosis of clinically atypical nevi (aN) and early melanomas (eMM) still represents a challenge even for experienced dermoscopists, as dermoscopy alone is not sufficient to adequately differentiate these equivocal melanocytic skin lesions (MSLs).

Objectives: The objectives of this study were to investigate what were the most relevant parameters for noninvasive differential diagnosis between eMM and aN among clinical, personal, and dermoscopic data and to evaluate their impact as risk factors for malignancy.

Methods: This was a retrospective study performed on 450 MSLs excised from 2014 to 2016 with a suspicion of malignancy. Read More

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http://dx.doi.org/10.5826/dpc.0804a16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246054PMC
October 2018
10 Reads

Distinct Genomic Patterns in Pigmented Epithelioid Melanocytoma: A Molecular and Histologic Analysis of 16 Cases.

Am J Surg Pathol 2019 Apr;43(4):480-488

Dermatology, Feinberg School of Medicine, Northwestern University.

Pigmented epithelioid melanocytoma (PEM) is considered an intermediate grade melanocytic lesion that is histologically indistinguishable from epithelioid blue nevi associated with Carney complex. PEM are characterized by an intradermal population of heavily pigmented epithelioid-shaped melanocytes along with some spindled and dendritic melanocytes with frequent melanophages. These melanocytic tumors occasionally involve regional lymph nodes but only rarely result in distant metastases. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001195DOI Listing
April 2019
16 Reads

Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus.

Case Rep Pediatr 2018 8;2018:7654278. Epub 2018 Oct 8.

Division of Pediatric Hematology/Oncology, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free. Read More

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http://dx.doi.org/10.1155/2018/7654278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196891PMC
October 2018
12 Reads

Nevus of Ota associated with a primary uveal melanoma and intracranial melanoma metastasis.

Cutis 2018 Sep;102(3):E2-E4

Department of Dermatology, University of Virginia, Charlottesville, USA.

Nevus of Ota is a blue, hyperpigmented, benign dermatosis of the skin and mucosae that most often occurs unilaterally in the distribution of the ophthalmic (V1) and maxillary (V2) branches of the trigeminal nerve. Although uncommon, association with malignant melanoma is a complication that must be considered in the evaluation of patients with nevus of Ota. Mutations in the and genes in patients with nevus of Ota place them at higher risk for malignant melanoma and metastasis. Read More

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September 2018
5 Reads

Sclerosing nevus with pseudomelanomatous features: dermoscopic and confocal aspects.

J Eur Acad Dermatol Venereol 2019 Mar 9;33(3):525-532. Epub 2018 Nov 9.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Background: Sclerosing nevus with pseudomelanomatous features (SNPFs) is a clinical and pathologic entity that mimics melanoma both clinically and histologically. The lesion is a melanocytic nevus, histologically characterized by fibrosis and a pseudomelanomatous proliferation. It is typically seen in young to middle-aged individuals, mainly on the back, where microtrauma or inflammatory changes are more frequent. Read More

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http://doi.wiley.com/10.1111/jdv.15284
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http://dx.doi.org/10.1111/jdv.15284DOI Listing
March 2019
6 Reads

Agminated blue nevus with a GNAQ mutation: A case report and review of the literature.

J Cutan Pathol 2019 Feb 19;46(2):130-133. Epub 2018 Nov 19.

Department of Dermatology, University of California, San Diego, California.

Agminated blue nevi are dermal melanocytic proliferations that classically present as dark blue macules or papules in a grouped, linear, or blaschkoid distribution. In their more common sporadic form, blue nevi manifest in young adulthood as solitary blue papules or macules on the scalp, face, hands, or feet. By contrast, agminated blue nevi tend to manifest earlier in life, and are distributed more evenly across anatomic sites. Read More

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http://doi.wiley.com/10.1111/cup.13373
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http://dx.doi.org/10.1111/cup.13373DOI Listing
February 2019
18 Reads

Agminated heterogeneous papules on the neck.

Cutis 2018 Aug;102(2):E24-E26

Dermatology Department, Naval Hospital Camp Lejeune, North Carolina, USA.

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August 2018
2 Reads

Blue Rubber Bleb Nevus Syndrome.

Anesthesiology 2018 Dec;129(6):1169

From the Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1097/ALN.0000000000002414DOI Listing
December 2018
1 Read

An update on molecular alterations in melanocytic tumors with emphasis on Spitzoid lesions.

Ann Transl Med 2018 Jun;6(12):249

First Department of Pathology, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

Significant progress in the molecular pathology of melanocytic tumors have revealed that benign neoplasms, so-called nevi, are initiated by gain-of-function mutations in one of several primary oncogenes, such as in acquired melanocytic nevi, in congenital nevi or / in blue nevi, with consequent MAPK and PI3K/AKT/mTOR activation. Secondary genetic alterations overcome tumor suppressive mechanisms and allow the progression to intermediate lesions characterized by TERT-p mutation or to invasive melanomas displaying disruption of tumor suppressor genes. Currently, melanoma is molecularly regarded as four different diseases, namely , , and the "triple wild type" subtypes, which are associated with particular clinicopathological features. Read More

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http://atm.amegroups.com/article/view/20068/19956
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http://dx.doi.org/10.21037/atm.2018.05.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046302PMC
June 2018
28 Reads

Statistical Detection of Colors in Dermoscopic Images With a Texton-Based Estimation of Probabilities.

IEEE J Biomed Health Inform 2019 Mar 5;23(2):560-569. Epub 2018 Apr 5.

Color has great diagnostic significance in dermatoscopy. Several diagnosis methods are based on the colors detected within a lesion. Malignant lesions frequently show more than three colors, whereas in benign lesions, three or fewer colors are usually observed. Read More

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http://dx.doi.org/10.1109/JBHI.2018.2823499DOI Listing
March 2019
1 Read

Surgery for Blue Rubber Bleb Nevus Syndrome-a Case Report.

Indian J Surg 2018 Jun 19;80(3):272-274. Epub 2017 Dec 19.

Department of General Surgery ,TMCH, Thanjavur, India.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disease characterised by multiple venous malformations and haemangioma in the skin and visceral organs. The lesion often involves the cutaneous and gastrointestinal tract. Most common visceral organ affected is the GIT. Read More

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http://dx.doi.org/10.1007/s12262-017-1715-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014949PMC
June 2018
35 Reads

Phototherapy-induced blistering reaction and eruptive melanocytic nevi in a child with transient neonatal porphyrinemia.

Pediatr Dermatol 2018 Sep 1;35(5):e272-e275. Epub 2018 Jul 1.

Department of Dermatology and Allergology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.

Neonatal blue-light phototherapy induced a blistering reaction followed by eruption of melanocytic nevi on the exposed skin surface of a child with transient neonatal porphyrinemia. New nevi are still developing 4 years after the triggering event. The role of phototoxicity-induced epidermal injury, that of porphyrins and the influence of neonatal blue-light therapy, in this unique phenomenon are discussed. Read More

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http://dx.doi.org/10.1111/pde.13569DOI Listing
September 2018
5 Reads

Osteoma Cutis Arising in Common Blue Nevus (Blue Osteonevus): A Clinicopathologic, Immunohistochemical, and Dermoscopic Study.

Am J Dermatopathol 2019 Feb;41(2):e19-e21

Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Osteonevus of Nanta is a rare histopathologic variant of melanocytic nevus that results from ossification of the dermis between dermal nests of melanocytes. Most cases described in the literature have been associated with long-standing intradermal nevi and were often located in the upper part of the body. We report a lesion on the shoulder of an elderly man showing the association of a common blue nevus and osteoma cutis, an exceptional feature which has been previously reported in 2 instances. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001211DOI Listing
February 2019
26 Reads

ALK Rearrangements Are Infrequent in Cellular Blue Nevus and Deep Penetrating Nevus.

Am J Dermatopathol 2018 Jul;40(7):469-478

Chief Resident (A.L.J.D.), Associate Professor (J.M.G., S.C.S.), Assistant Professor (J.R.K.), Professor (W.B.), Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR.

Recent studies have identified kinase fusions in Spitzoid melanocytic neoplasms, and approximately 10% of Spitzoid neoplasms harbor anaplastic lymphoma kinase (ALK) rearrangements and corresponding ALK immunoreactivity. Deep penetrating nevi (DPN), a subset of melanocytic neoplasms, have histologic and immunohistochemical overlap that have historically supported classification of DPN with blue/cellular blue nevi (CBN). However, HRAS mutations have rarely been detected in DPN, thereby also linking them to Spitz nevi. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001014DOI Listing
July 2018
26 Reads

Integrated Genomic Classification of Melanocytic Tumors of the Central Nervous System Using Mutation Analysis, Copy Number Alterations, and DNA Methylation Profiling.

Clin Cancer Res 2018 Sep 11;24(18):4494-4504. Epub 2018 Jun 11.

Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Germany.

In the central nervous system, distinguishing primary leptomeningeal melanocytic tumors from melanoma metastases and predicting their biological behavior solely using histopathologic criteria may be challenging. We aimed to assess the diagnostic and prognostic value of integrated molecular analysis. Targeted next-generation sequencing, array-based genome-wide methylation analysis, and BAP1 IHC were performed on the largest cohort of central nervous system melanocytic tumors analyzed to date, including 47 primary tumors of the central nervous system, 16 uveal melanomas, 13 cutaneous melanoma metastases, and 2 blue nevus-like melanomas. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0763DOI Listing
September 2018
8 Reads

Nevus Blue as a Sporadic Finding in a Patient with a Blue Toe?

Open Access Maced J Med Sci 2018 May 15;6(5):855-858. Epub 2018 May 15.

Medical Institute of the Ministry of Interior (MVR-Sofia), Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.

Background: Blue nevus is an interesting finding, which aetiology and risk of locoregional and distant metastasis have not yet been fully clarified. It may be inherited or acquired, with sporadic cases usually presented as solitary lesions. It is often localised in the area of the head and less often on the arms, legs or trunk. Read More

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http://dx.doi.org/10.3889/oamjms.2018.228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985889PMC
May 2018
28 Reads

Metastatic Blue Nevus-Like Melanoma Detected by Liquid-Based Catheterized Urine Cytology.

Ann Dermatol 2018 Jun 23;30(3):356-360. Epub 2018 Apr 23.

Department of Pathology, Ajou University School of Medicine, Suwon, Korea.

Primary or metastatic malignant melanoma can mimic benign blue nevus in rare cases, making the diagnosis challenging. Herein, we report an exceptionally rare case of blue nevus-like melanoma and its blue nevus-like metastasis which was detected by catheterized urine cytology. The patient presented with blue-colored papuloplaques on his temple which were diagnosed as blue nevus-like melanoma on punch biopsies. Read More

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http://dx.doi.org/10.5021/ad.2018.30.3.356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929957PMC
June 2018
21 Reads

A 10-year delayed diagnosis of blue rubber bleb nevus syndrome characterized by refractory iron-deficiency anemia: A case report and literature review.

Medicine (Baltimore) 2018 Jun;97(22):e10873

Department of Pediatrics, West China Second University Hospital.

Rationale: Blue rubber bleb nevus syndrome (BRBNS) is a rare vascular disorder consisting of multifocal venous malformations. Delayed diagnosis or misdiagnosis frequently occurs in patients without typical cutaneous lesions or gastrointestinal bleeding symptoms. This article reports a 10-year case of delayed diagnosis of BRBNS detected by capsule endoscopy. Read More

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http://dx.doi.org/10.1097/MD.0000000000010873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392564PMC
June 2018
9 Reads

Dermoscopy of a Spark's nevus.

Dermatol Pract Concept 2018 Apr 30;8(2):126-128. Epub 2018 Apr 30.

Dermatology Unit, Galliera Hospital, Genoa, Italy.

Spark's nevus is a particular type of melanocytic nevus that on histology shows features of both Spitz's and Clark's nevus. Clinically, it is an asymmetric, irregular, multicolored, pigmented lesion that is not clearly distinguishable from melanoma or dysplastic (Clark's) nevus. Dermoscopic features have not been described yet, and one could speculate that they are similar to those of Clark's nevi because the histopathologic architecture of Spark's nevus is similar to that of a Clark's nevus, resembling Spitz's nevi in the epithelioid morphology of melanocytes. Read More

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http://dx.doi.org/10.5826/dpc.0802a11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955080PMC
April 2018
2 Reads

Role of In Vivo Reflectance Confocal Microscopy in the Analysis of Melanocytic Lesions.

Acta Dermatovenerol Croat 2018 Apr;26(1):64-67

Elena-Daniela Serban, MD, Department of Medical Oncology, University of Bologna, 40138 Bologna; Italy.

Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. Read More

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April 2018
10 Reads

Microphthalmia-associated transcription factor (MiTF): Promiscuous staining patterns in fibrohistiocytic lesions is a potential pitfall.

Pathol Res Pract 2018 Jun 11;214(6):821-825. Epub 2018 May 11.

Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:

Microphthalmia-associated transcription factor (MiTF) is used as a marker of melanocytic differentiation. However, MiTF immunoexpression has also been observed in histiocytes, macrophages, smooth muscle cells and fibroblasts, which raise the concern of fibrohistiocytic (FH) lesions being misdiagnosed as melanoma based on MiTF immunoreactivity. MiTF has been known to be positive in FH tumors, but this is the first study evaluating ninety-three fibrohistiocytic neoplasms to understand and delineate the staining pattern of MiTF in these tumors. Read More

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http://dx.doi.org/10.1016/j.prp.2018.05.001DOI Listing
June 2018
39 Reads
1.562 Impact Factor

Plexiform Atypical Spitz Tumor With Rosette-Like Giant Cells: A Histologic and Immunohistochemical Study on a Case Suggesting Ganglioneuroblastic Differentiation: Review of the Literature and Considerations on Histogenesis.

Am J Dermatopathol 2018 Dec;40(12):903-907

Department of Biomedicine, Internal Medicine, and Specialized, Medicine (DIBIMIS), Section of Dermatology, University of Palermo, AOUP Paolo Giaccone, Palermo, PA, Italy.

Spitz nevi, atypical Spitz tumors and Spitzoid melanoma, the three clinicopathologic forms that constitute the spectrum of the Spitz-type melanocytic lesions, share a histologic picture characterized by large spindle and/or epithelioid ganglion-like cells, with various admixtures of multinucleate bizarre cells. This remarkable cytology has always been interpreted as an unusual, as well as unexplained form of atypia. We report a case of atypical Spitz tumor with Homer Wright-like rosettes, a feature characteristic of ganglioneuroblastic proliferation. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001184DOI Listing
December 2018
6 Reads

Orbital melanocytoma: When a tumor becomes a relieving surprise.

Am J Ophthalmol Case Rep 2018 Jun 24;10:124-127. Epub 2018 Feb 24.

Ophthalmology Department, Kasr Al Ainy school of medicine, Cairo University, Cairo, Egypt.

Purpose: Melanocytomas are rare pigmented tumors that arise form melanocytes and have been reported in the central nervous system. Orbital melanocytomas "also known as blue nevus" are rarely reported. The occurrence of choroidal melanoma and orbital melanocytomas has never been described. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936173034
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http://dx.doi.org/10.1016/j.ajoc.2018.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910506PMC
June 2018
10 Reads

A Rare Case of Multifocal Prostatic Blue Nevus.

Case Rep Urol 2018 21;2018:7820717. Epub 2018 Feb 21.

Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, USA.

Prostatic blue nevus is a rare benign pathologic diagnosis most commonly diagnosed incidentally on many different types of prostate specimens. Blue nevus is the deposition of stromal melanin characterized by spindle cells within the fibromuscular stroma which stains positive for melanin-specific stains Fontana-Masson and S100 and stains negative for CD68, HMB45, and iron stains. We report the case of a multifocal and bilateral blue nevus in a 52-year-old Hispanic male who presented with an elevated prostate-specific antigen of 4. Read More

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http://dx.doi.org/10.1155/2018/7820717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841115PMC
February 2018
3 Reads

An unusual cause of gastrointestinal bleeding in a hemodialysis patient.

Hemodial Int 2018 10 2;22(4):E60-E62. Epub 2018 Apr 2.

AURA Paris Plaisance, Paris, France.

Iron deficiency caused by gastrointestinal (GI) bleeding is a common cause of anemia in hemodialysis patient. Herein, we report the case of an 89-year-old hemodialysis patient who presented with acute anemia and melena. Endoscopy found gastritis and diverticulosis without active bleeding. Read More

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http://dx.doi.org/10.1111/hdi.12657DOI Listing
October 2018
33 Reads

[Blue rubber bleb naevus syndrome involving the pleura].

Rev Mal Respir 2018 Mar 28;35(3):333-337. Epub 2018 Mar 28.

Service d'oncologie thoracique, maladies de la plèvre et pneumologie interventionnelle, hôpital Nord, chemin des Bourrely, 13015 Marseille, France; Aix-Marseille université, 13284 Marseille cedex 07, France. Electronic address:

Bean's syndrome ('blue rubber bleb nevus syndrome') is a rare disease characterized by venous malformations involving various organs. Most often these lesions are localized to the skin and the digestive system. Gastro-intestinal bleeding is the most frequent presentation. Read More

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http://dx.doi.org/10.1016/j.rmr.2017.06.006DOI Listing

Solitary pigmented lesions in oral mucosa in Latin American children: A case series.

Pediatr Dermatol 2018 May 24;35(3):374-377. Epub 2018 Mar 24.

Department of Pathology and Oral Medicine, School of Dentistry, Oral Medicine Clinic, Universidad de Chile, Santiago, Chile.

Background: A variety of local and systemic processes caused exogenous and endogenous pigmentation of the oral mucosa. Solitary melanotic pigmentation is rare, hence the scarce number of studies in children and adolescents.

Methods: Clinical and histopathologic features of 10 Latin American children with solitary pigmented lesions of the oral mucosa were reviewed. Read More

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http://dx.doi.org/10.1111/pde.13465DOI Listing
May 2018
9 Reads

Blue Nevi of the Ocular Surface: Clinical Characteristics, Pathologic Features, and Clinical Course.

Ophthalmology 2018 Aug 15;125(8):1189-1198. Epub 2018 Mar 15.

Bascom Palmer Eye Institute, University of Miami, Miami, Florida. Electronic address:

Purpose: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Read More

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http://dx.doi.org/10.1016/j.ophtha.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056321PMC
August 2018
10 Reads

Fern-shaped patch as a hallmark of blue rubber bleb nevus syndrome in neonatal venous malformations.

Eur J Pediatr 2018 Sep 8;177(9):1395-1398. Epub 2018 Mar 8.

Department of Pediatric Surgery, University Hospital La Paz, Madrid, Spain.

Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital vascular disease associated with important morbidity and non-insignificant risk of mortality in cases of severe gastrointestinal or neurological involvement. Early diagnosis in the neonatal period can be difficult as very often skin lesions appear progressively during childhood having no correlation with gastrointestinal lesion development. The appearance of one large venous malformation (VM) in the neonatal period has suggested a characteristic finding of this syndrome. Read More

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http://dx.doi.org/10.1007/s00431-018-3126-xDOI Listing
September 2018
9 Reads