1,828 results match your criteria Blue Nevi


Obstetric and Neonatal Outcome of Pregnancy in Carney Complex: A Case Report.

Front Endocrinol (Lausanne) 2020 8;11:296. Epub 2020 May 8.

Department of Obstetrics and Gynecology, University Bonn Medical School, Bonn, Germany.

Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome with autosomal dominant inheritance. Affected individuals present with mucocutaneous lentigines/blue nevi, cardiac and noncardiac myxomatous tumors, and multiple endocrine tumors. Mutations in have been identified as genetic cause of the disease. Read More

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http://dx.doi.org/10.3389/fendo.2020.00296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225262PMC

Eruptive Blue Nevi: A Rare Phenomenon Diagnosed With the Aid of Dermoscopy.

Dermatol Pract Concept 2020 3;10(2):e2020041. Epub 2020 Apr 3.

Department of Dermatology, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Jerusalem, Israel.

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http://dx.doi.org/10.5826/dpc.1002a41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190562PMC

Screening and Intervention for Skin Cancer in the Galapagos.

Ann Plast Surg 2020 Apr 28. Epub 2020 Apr 28.

Division of Plastic and Reconstructive Surgery at Stony Brook University Hospital.

Objective: This study aimed to assess the general dermatological needs and correlation of tentative skin cancer screening diagnoses with histopathological confirmation in the highly sun-exposed locals of the Galapagos Islands.

Methods: An institutional review board-approved prospective study was performed at Blanca's House, a nonprofit surgical volunteer organization, free clinics in the Galapagos. After consent, a 40-item modified SPOTme-inspired questionnaire was completed. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002345DOI Listing

p16 Range of Expression in Dermal Predominant Benign Epithelioid and Spindled Nevi and Melanoma.

J Cutan Pathol 2020 Apr 24. Epub 2020 Apr 24.

Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.

Background: Screening borderline Spitz tumors with p16 immunohistochemistry has known utility. The applicability to other melanocytic neoplasms is not well defined.

Methods: Cases (N = 104) of blue, cellular blue, epithelioid blue, congenital pattern, deep penetrating, desmoplastic, desmoplastic Spitz, acral, "epithelioid" nevi, nevoid melanoma, melanoma with a precursor nevus, and non-nevoid melanoma with Breslow thickness > 0. Read More

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http://dx.doi.org/10.1111/cup.13721DOI Listing

Blue Rubber Bleb Nevus Syndrome With Multiple Cavernoma-Like Lesions on MRI: A Familial Case Report and Literature Review.

Front Neurol 2020 7;11:176. Epub 2020 Apr 7.

Department of Neurology, Instituto Nacional de Neurología y Neurocirugía "Dr. Manuel Velasco Suarez", Mexico City, Mexico.

Blue rubber bleb nevus syndrome (BRBNS), also called Bean's syndrome, is a rare disease associated with multiple venous malformations in the skin and gastrointestinal (GI) tract. Dermatological lesions, which are the first clinically visible manifestations, appear as skin-colored compressible protuberances or as dark-blue venous nodules, rubbery in consistency. Central nervous system (CNS) manifestations are rare, variable, non-specific, and tend to occur late in the disease, mainly reported as seizures and focal neurological deficits secondary to compression. Read More

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http://dx.doi.org/10.3389/fneur.2020.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154106PMC

BAP-1 Expression Status by Immunohistochemistry in Cellular Blue Nevus and Blue Nevus-like Melanoma.

Am J Dermatopathol 2020 May;42(5):313-321

Associate Professor, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

The family of blue nevi includes the common blue nevus (BN), cellular blue nevus (CBN), and atypical BN, while melanomas with BN-like morphology can either arise in association with a blue nevus (MABN) or in the de novo setting mimicking cellular blue nevus (MMCBN). Recent molecular and immunohistochemical studies have demonstrated loss of BAP-1 in MABN/MMCBN but not in BN/CBN, suggesting that loss of BAP-1 correlates with a malignant phenotype in these lesions. In this study, we applied anti-BAP-1 antibodies to a series of CBN/BN (n = 11) and MABN/MMCBN (n = 4). Read More

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http://dx.doi.org/10.1097/DAD.0000000000001551DOI Listing
May 2020
1.426 Impact Factor

Melanoma Ex Blue Nevus With GNA11 Mutation and BAP1 Loss: Case Report and Review of the Literature.

Am J Dermatopathol 2020 Apr 17. Epub 2020 Apr 17.

Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA.

Cutaneous melanomas may demonstrate a variety of histopathological features and genetic abnormalities. Melanomas that arise in the setting of blue nevi, also known as "malignant blue nevus" or melanoma ex blue nevus (MBN), share a similar histopathological and mutational profile with uveal melanoma. Most uveal melanomas show characteristic GNA11 or GNAQ mutations; additional BAP1 mutation or loss is associated with the highest risk of metastasis and worst prognosis. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001652DOI Listing
April 2020
1.426 Impact Factor

The dermoscopic pattern of blue nevi involving the nail apparatus.

Eur J Dermatol 2020 Apr 16. Epub 2020 Apr 16.

Dermatology - Department of Experimental, Diagnostic and Specialty Medicine (DIMES) Alma Mater Studiorum University of Bologna, Italy.

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http://dx.doi.org/10.1684/ejd.2020.3726DOI Listing

Targeted next generation sequencing (NGS) to classify melanocytic neoplasms.

J Cutan Pathol 2020 Apr 15. Epub 2020 Apr 15.

Dermatopathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.

This study piloted a pan-solid-tumor next generation sequence (NGS)-based laboratory developed test as a diagnostic aid in melanocytic tumors. 31 cases (4 "epithelioid" nevi, 5 blue nevi variants, 7 Spitz tumors [3 benign and 4 malignant] and 15 melanomas) were evaluated. All tumors [median diameter 7 mm (range 4-15 mm); median thickness 2. Read More

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http://dx.doi.org/10.1111/cup.13695DOI Listing

Three Types of Nodal Melanocytic Nevi in Sentinel Lymph Nodes of Patients With Melanoma: Pitfalls, Immunohistochemistry, and a Review of the Literature.

Am J Dermatopathol 2020 Apr 7. Epub 2020 Apr 7.

Department of Pathology, The University of Texas-MD Anderson Cancer Center, Houston, TX.

The presence or absence of metastasis in sentinel lymph nodes often drives melanoma staging, prognosis, and treatment. However, distinguishing between metastatic melanoma cells and clusters of benign melanocytic nevus cells is not always straightforward. When morphologic hematoxylin and eosin interpretation alone is not sufficient, additional hematoxylin and eosin sections and immunohistochemical (IHC) studies may be beneficial. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001645DOI Listing

Osteonevus of Nanta: a case report in a combined melanocytic nevus.

An Bras Dermatol 2020 May - Jun;95(3):351-354. Epub 2020 Mar 19.

Service of Dermatology Surgery, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

Secondary osteoma cutis is a phenomenon that may occur in several conditions. When it occurs in a melanocytic nevus it is named osteonevus of Nanta, an event considered uncommon and characterized by the presence of bone formation adjacent or interposed with melanocytic cells. There are reports of its occurrence in various melanocytic lesions, being more frequently associated with intradermal nevus. Read More

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http://dx.doi.org/10.1016/j.abd.2019.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253887PMC

Obscure gastrointestinal bleeding in the setting of blue rubber bleb nevus syndrome with extensive small bowel involvement.

Rev Esp Enferm Dig 2020 Apr;112(4):323-324

Gastroenterology, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder characterized by multiple vascular malformations of the gastrointestinal (GI) tract, skin and less frequently in solid organs. An 85-year-old male was admitted to the ER due to melena and was under apixaban anticoagulation. Dorsal hemangiomas were identified on physical examination. Read More

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http://dx.doi.org/10.17235/reed.2020.6963/2020DOI Listing

Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions.

Cureus 2020 Feb 11;12(2):e6955. Epub 2020 Feb 11.

Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.

Cutaneous tender tumors manifest as painful dermal or subcutaneous masses. Acronyms, a memory aid created from the initial letters of other words, can be used to assist in recalling a list of conditions. We report the case of a man who presented with a painful lesion on his leg; 15 years earlier, hot solder had embedded beneath his skin at that location. Read More

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http://dx.doi.org/10.7759/cureus.6955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067514PMC
February 2020

Blue papule on a nevus spilus.

Med Clin (Barc) 2020 Mar 3. Epub 2020 Mar 3.

Servicio de Dermatología, Hospital Universitario Severo Ochoa, Leganés, Madrid, España.

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http://dx.doi.org/10.1016/j.medcli.2019.12.013DOI Listing

Genomic and Clinicopathologic Characteristics of PRKAR1A-inactivated Melanomas: Toward Genetic Distinctions of Animal-type Melanoma/Pigment Synthesizing Melanoma.

Am J Surg Pathol 2020 Jun;44(6):805-816

Departments of Pathology.

Melanocytic tumors with inactivation of protein kinase A regulatory subunit-α (PRKAR1A) have large oval nuclei and intense pigmentation. Historically, these tumors have been categorized under various names, including epithelioid blue nevus, pigmented epithelioid melanocytoma (PEM) and animal-type melanoma. Although a subset of PEM harbor BRAF activating mutations and biallelic inactivation of PRKAR1A, there are only a few reports of melanomas, or of tumors with genomic alterations beyond those of PEMs. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001458DOI Listing

The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.

Arch Pathol Lab Med 2020 Apr 14;144(4):500-522. Epub 2020 Feb 14.

From the Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia (Dr Elder); the Department of Dermatology, University of California San Francisco, San Francisco (Dr Bastian); International Agency for Research on Cancer, Lyon, France (Dr Cree); Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy (Dr Massi); and the Department of Pathology and Melanoma Institute Australia, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia (Dr Scolyer).

Context.—: There have been major advances in the understanding of melanoma since the last revision of the World Health Organization (WHO) classification in 2006.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2019-0561-RADOI Listing

Blue nevus with satellitosis: a case report in a pregnant patient.

G Ital Dermatol Venereol 2020 Feb 5. Epub 2020 Feb 5.

Department of Dermatology and Venereology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.23736/S0392-0488.19.06409-5DOI Listing
February 2020

Anesthetic considerations for blue rubber bleb nevus syndrome: a case report.

JA Clin Rep 2019 Dec 16;5(1):83. Epub 2019 Dec 16.

Department of Anesthesia, Teine Keijinkai Hospital, 1-12-1-40 Maeda, Teine, Sapporo, 006-8555, Japan.

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http://dx.doi.org/10.1186/s40981-019-0304-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967292PMC
December 2019

Melanoma recognition by a deep learning convolutional neural network-Performance in different melanoma subtypes and localisations.

Eur J Cancer 2020 Mar 20;127:21-29. Epub 2020 Jan 20.

Department of Dermatology, University of Heidelberg, Heidelberg, Germany. Electronic address:

Background: Deep learning convolutional neural networks (CNNs) show great potential for melanoma diagnosis. Melanoma thickness at diagnosis among others depends on melanoma localisation and subtype (e.g. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.11.020DOI Listing

Blue Nevus With Rosettes on Polarized Light Dermoscopy.

Dermatol Pract Concept 2020 31;10(1):e2020017. Epub 2019 Dec 31.

Dermatology Department, Melanoma Unit, Hospital Clínic of Barcelona, Barcelona University, Spain.

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http://dx.doi.org/10.5826/dpc.1001a17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936647PMC
December 2019

Acquired Asymptomatic Blue Tongue: A Report of Exogenous Agent-associated Tongue Dyschromia and Review of Blue Tongue Etiologies.

Authors:
Philip R Cohen

Cureus 2019 Nov 27;11(11):e6243. Epub 2019 Nov 27.

Dermatology, San Diego Family Dermatology, San Diego, USA.

This study presents the case of a man who developed a temporary and asymptomatic blue tongue. The dyschromia occurred following topical contact with gelato that contained Food, Drug, and Cosmetic (FD&C) blue dye no. 1. Read More

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http://dx.doi.org/10.7759/cureus.6243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935329PMC
November 2019

Low-dose sirolimus for a patient with blue rubber bleb nevus syndrome.

Pediatr Int 2020 Jan 27;62(1):112-113. Epub 2019 Dec 27.

Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan.

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http://dx.doi.org/10.1111/ped.14059DOI Listing
January 2020

Blue rubber bleb nevus: a rare cause of GI bleeding-review of management.

BMJ Case Rep 2019 Dec 16;12(12). Epub 2019 Dec 16.

Gastroenterology, AdventHealth Medical Group, Apopka, Florida, USA.

Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital vascular anomaly syndrome characterised by multifocal venous vascular malformations. It involves skin, central nervous systems, liver, muscles and gastrointestinal (GI) tract resulting in intestinal haemorrhage and anaemia. Patients with BRBNS experience severe chronic anaemia without any diagnosis requiring multiple transfusions and hospitalisations. Read More

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http://dx.doi.org/10.1136/bcr-2019-231561DOI Listing
December 2019

High-frequency ultrasound in the diagnosis of selected non-melanoma skin nodular lesions.

Postepy Dermatol Alergol 2019 Oct 12;36(5):572-580. Epub 2019 Nov 12.

Chair and Department of Dermatology, Venerology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.

Introduction: Ultrasonographic examination is commonly used in an outpatient setting, possibly due to its low cost, low risk for patients and the possibility to obtain real time images. Typically used heads have the frequency ranging from 7.5 to 12 MHz. Read More

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http://dx.doi.org/10.5114/ada.2019.89505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906959PMC
October 2019

Successful treatment of a patient with multicolored nevus of Ota using a combination of 1064 and 532 nm Q-switched Nd:YAG lasers.

J Cosmet Laser Ther 2020 11;22(1):27-29. Epub 2019 Dec 11.

Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.

Nevus of Ota (NO) is a hamartoma of dermal melanocytes usually presents as unilateral blue, gray or brown macules or patches. It can impose a high burden of cosmetic and psychological disturbances in affected individuals. Q-Switched lasers appear to be an effective treatment for this kind of dermal melanocytosis. Read More

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http://dx.doi.org/10.1080/14764172.2019.1701683DOI Listing
December 2019

Rare Germline Variants Identified from Blue Rubber Bleb Nevus Syndrome Might Impact mTOR Signaling.

Comb Chem High Throughput Screen 2019 ;22(10):675-682

State Key Laboratory for Medical Genetics, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SITUSM) and Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai 200031, China.

Background And Objective: Blue rubber bleb nevus syndrome (BRBN) or Bean syndrome is a rare Venous Malformation (VM)-associated disorder, which mostly affects the skin and gastrointestinal tract in early childhood. Somatic mutations in TEK have been identified from BRBN patients; however, the etiology of TEK mutation-negative patients of BRBN need further investigation.

Methods: Two unrelated sporadic BRBNs and one sporadic VM were firstly screened for any rare nonsilent mutation in TEK by Sanger sequencing and subsequently applied to whole-exome sequencing to identify underlying disease causative variants. Read More

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http://dx.doi.org/10.2174/1386207322666191203110042DOI Listing
January 2019

Compound blue nevus: a reappraisal of the concept in the genomic era.

Virchows Arch 2020 Mar 21;476(3):439-443. Epub 2019 Nov 21.

Department of Biopathology, Center Léon Bérard, 28, Rue Laennec, 69008, Lyon, France.

We report a series of 21 compound blue nevi, a rare variant in the vast clinical and morphological spectrum of blue melanocytic proliferations. Clinically, they presented in young adults, with a slight female predominance. One-third were located on the dorsum of the foot. Read More

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http://dx.doi.org/10.1007/s00428-019-02667-wDOI Listing
March 2020
2.651 Impact Factor

Blue rubber bleb nevus syndrome of the orbit and gastrointestinal tract.

Orbit 2019 Nov 12:1-2. Epub 2019 Nov 12.

Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1080/01676830.2019.1687737DOI Listing
November 2019

Postural changes revealing orbital venous malformation using ultrasound in blue rubber bleb nevus syndrome.

Orbit 2019 Nov 6:1-5. Epub 2019 Nov 6.

NESMOS Department, Ophthalmology Unit, S. Andrea Hospital, University of Rome "La Sapienza", Rome, Italy.

A 62-year-old white woman presented with a diagnosis of blue rubber bleb nevus syndrome (BRBNS). The right eye appeared enophthalmic, yet the patient complained of episodes of right proptosis on bending forward. The remainder of the examination was unremarkable. Read More

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http://dx.doi.org/10.1080/01676830.2019.1688357DOI Listing
November 2019

GNAQ expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.

Pigment Cell Melanoma Res 2020 01 20;33(1):96-111. Epub 2019 Nov 20.

Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.

Primary leptomeningeal melanocytic neoplasms represent a spectrum of rare tumors originating from melanocytes of the leptomeninges, which are the inner two membranes that protect the central nervous system. Like other non-epithelial melanocytic lesions, they bear frequent oncogenic mutations in the heterotrimeric G protein alpha subunits, GNAQ or GNA11. In this study, we used Plp1-creERT to force the expression of oncogenic GNAQ in the multipotent neural crest cells of the ventro-medial developmental pathway, beginning prior to melanocyte cell differentiation. Read More

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http://dx.doi.org/10.1111/pcmr.12843DOI Listing
January 2020
1 Read

An extensive nevus of Ota with oro-buccal involvement: a case review and proposal of a new classification system.

Authors:
Betul Tas

G Ital Dermatol Venereol 2019 Oct;154(5):581-585

Department of Dermatology, Istanbul Bagcilar Research and Training Hospital, University of Health Sciences, Istanbul, Turkey -

Nevus of Ota (NO) also known as nevus fuscoceruleus ophthalmomaxillaris or oculodermal melanocytosis is a rare hamartoma. It is usually characterized by unilateral, patchy and speckled, blue/gray or brown macules on the forehead and periocular area. Here, we report a rare case of NO with oro-buccal involvement, which is an unusual condition. Read More

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http://dx.doi.org/10.23736/S0392-0488.17.05150-1DOI Listing
October 2019
1 Read

Nevus-associated melanoma: An observational retrospective study of 22 patients evaluated with dermoscopy and reflectance confocal microscopy.

Skin Res Technol 2020 Jan 25;26(1):99-104. Epub 2019 Sep 25.

Dermatology Unit, Hospital Fundación Alcorcón, Alcorcón, Spain.

Background: The frequency of nevus-associated melanoma (NAM) has been estimated to be 29% of diagnosed melanomas.

Materials And Methods: This is an observational retrospective study of 22 cases of NAM diagnosed in the Universitary Hospital Alcorcón between September 2011 and 2018. The main objective was to analyze dermoscopic and RCM features of NAM. Read More

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http://dx.doi.org/10.1111/srt.12770DOI Listing
January 2020
3 Reads

Treatment response to checkpoint immunotherapy in a patient with a melanoma ex blue nevus.

J Cutan Pathol 2020 Jan 7;47(1):108. Epub 2019 Oct 7.

Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.

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http://dx.doi.org/10.1111/cup.13578DOI Listing
January 2020
2 Reads

Eruptive Blue Nevi of the Scalp in a Patient with Mayer-Rokitansky-Küster-Hauser Syndrome during Isotretinoin Therapy.

Indian J Dermatol 2019 Jul-Aug;64(4):339

Department of Medical-Surgical Sciences and Bio-Technologies, Dermatology Unit "Daniele Innocenzi", Sapienza University of Rome, Fiorini Hospital, Polo Pontino, Terracina, Italy. E-mail:

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http://dx.doi.org/10.4103/ijd.IJD_188_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714184PMC
September 2019
2 Reads

Blue Nevus Developing at a Combined Tetanus, Diphtheria, and Pertussis (Tdap) Vaccination Site: Case Report and Summary of Vaccine-Associated Cutaneous Lesions.

Cureus 2019 Jun 25;11(6):e4997. Epub 2019 Jun 25.

Dermatology, San Diego Family Dermatology, National City, USA.

Skin reaction may develop at the site of vaccine administration. A 54-year-old woman who developed a cellular blue nevus at the site of the combined tetanus, diphtheria, and acellular pertussis (Tdap) vaccine injection four years prior to presentation is described. In addition to blue nevus, other reactions at combined tetanus, diphtheria, and pertussis vaccine injection sites include abscess, deep reactive nodular infiltrates of mixed inflammation, and necrotizing granuloma. Read More

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https://www.cureus.com/articles/19936-blue-nevus-developing-
Publisher Site
http://dx.doi.org/10.7759/cureus.4997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707821PMC
June 2019
3 Reads

A pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3-SCAPER gene fusion.

J Cutan Pathol 2020 Jan 11;47(1):70-75. Epub 2019 Sep 11.

Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, Michigan.

Pigmented epithelioid melanocytoma (PEM) represents a group of rare, heavily pigmented melanocytic tumors encompassing lesions previously designated as "animal-type melanomas" and "epithelioid blue nevi." Despite the association of multiple such tumors in the setting of Carney complex, most cases of PEM occur spontaneously as solitary neoplasms in otherwise healthy patients. PEM may arise in both children and adults, and has a known propensity to spread to the regional lymph nodes. Read More

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http://dx.doi.org/10.1111/cup.13566DOI Listing
January 2020
4 Reads

Melanocytic Skin Neoplasms: What Lesson From Genomic Aberrations?

Authors:
Carmelo Urso

Am J Dermatopathol 2019 Sep;41(9):623-629

Scientific Director, Dermatopathology Study Center of Florence, Florence, Italy.

Studies on the genomic aberrations in melanocytic neoplasms have shown a complex genomic landscape. In nevi and melanomas, a MAP-kinase pathway activation was generally found, produced by different chromosomal aberrations, including BRAF, NRAS, HRAS, GNAQ, GNA11, BAP1, CTNNB1, MAP2K1, PRKAR1A, and NF1 mutations, and ALK, ROS1, NTRK1, RET, MET, BRAF, NTRK3, and PRKCA fusions. Melanomas also showed a variable number of additional mutations ablating tumor-suppression mechanisms and activating other oncogenic pathways, including CDKN2A loss, PTEN loss, as well as TP53 and TERT-promoter mutations. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001341DOI Listing
September 2019
4 Reads

Association Between Surgical Skin Markings in Dermoscopic Images and Diagnostic Performance of a Deep Learning Convolutional Neural Network for Melanoma Recognition.

JAMA Dermatol 2019 Aug 14. Epub 2019 Aug 14.

Department of Dermatology, University of Heidelberg, Heidelberg, Germany.

Importance: Deep learning convolutional neural networks (CNNs) have shown a performance at the level of dermatologists in the diagnosis of melanoma. Accordingly, further exploring the potential limitations of CNN technology before broadly applying it is of special interest.

Objective: To investigate the association between gentian violet surgical skin markings in dermoscopic images and the diagnostic performance of a CNN approved for use as a medical device in the European market. Read More

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http://dx.doi.org/10.1001/jamadermatol.2019.1735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694463PMC
August 2019
3 Reads

Melanocytoma of the Conjunctiva: Clinicopathologic Features of Three Cases.

Ocul Oncol Pathol 2019 Jun 18;5(4):290-297. Epub 2019 Mar 18.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Background: Melanocytoma (magnocellular nevus) is a jet-black benign lesion histologically composed of polygonal tumor cells with small, inconspicuous nuclei and abundant cytoplasm. Melanocytomas in general are rare. Most cases occur in the optic nerve head. Read More

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http://dx.doi.org/10.1159/000496557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615338PMC
June 2019
3 Reads

Blue rubber bleb nevus syndrome.

CMAJ 2019 07;191(30):E841

Department of Medicine, University of Saskatchewan, Saskatoon, Sask.

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http://dx.doi.org/10.1503/cmaj.190173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663495PMC
July 2019
4 Reads

Diagnosis and management of children with Blue Rubber Bleb Nevus Syndrome: A multi-center case series.

Dig Liver Dis 2019 11 26;51(11):1537-1546. Epub 2019 Jul 26.

Centre of Paediatric Gastroenterology, Sheffield Children's Hospital, Sheffield, United Kingdom.

Background: Blue Rubber Bleb Nevus Syndrome (BRBNS) is a rare, severe, sporadically occurring disorder characterized by multiple venous malformations.

Aims: To present and analyze a case series of pediatric patients with BRBNS and to describe diagnostic approaches and management options applied.

Patients And Methods: Multicenter, retrospective study, evaluating the diagnosis and management of children with BRBNS. Read More

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http://dx.doi.org/10.1016/j.dld.2019.04.020DOI Listing
November 2019
7 Reads

Concomitant GNA11 and SF3B1 mutations in two cases of melanoma associated with blue naevus.

Clin Exp Dermatol 2020 Jan 23;45(1):123-126. Epub 2019 Jul 23.

Faculté de Médecine Lyon Est, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.

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http://dx.doi.org/10.1111/ced.14036DOI Listing
January 2020

Generalized congenital epithelioid blue nevi (pigmented epithelioid melanocytomas) in an infant: Report of case and review of the literature.

J Cutan Pathol 2019 Dec 22;46(12):954-959. Epub 2019 Jul 22.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

The epithelioid blue nevus (EBN) is a variant of the blue nevus characterized by heavily pigmented epithelioid melanocytes and lightly or nonpigmented spindle cells. It may be associated with Carney complex, a multiple neoplasia syndrome. Congenital cases of EBN not associated with Carney complex are rarely reported. Read More

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http://dx.doi.org/10.1111/cup.13544DOI Listing
December 2019
5 Reads

Visual perception training: a prospective cohort trial of a novel, technology-based method to teach melanoma recognition.

Postgrad Med J 2019 Jun;95(1124):350-352

Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

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http://dx.doi.org/10.1136/postgradmedj-2018-136379DOI Listing
June 2019
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1.549 Impact Factor

Blue rubber bleb nevus syndrome in geriatric patients.

Rev Gastroenterol Mex 2020 Apr - Jun;85(2):215-216. Epub 2019 Jun 27.

Servicio de Endoscopia, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, CDMX, México.

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http://dx.doi.org/10.1016/j.rgmx.2019.03.004DOI Listing
June 2019
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Successful management of anemia with sirolimus in blue rubber bleb nevus syndrome: case report and update.

Rev Esp Enferm Dig 2019 Aug;111(8):643-647

Estudiante de Medicina, Fundación Hospital de Alcorcón, España.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder with characteristic skin hemangiomas and vascular malformations, mostly in the gastrointestinal (GI) tract. The GI lesions are mainly located in the stomach and small intestine, usually more than a hundred, leading to gastrointestinal bleeding and severe chronic anemia. Parenteral iron infusions and scheduled transfusions are frequently necessary. Read More

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http://dx.doi.org/10.17235/reed.2019.6250/2019DOI Listing
August 2019
13 Reads

Pulmonary embolism during pregnancy in a case of blue rubber bleb nevus syndrome.

Chin Med J (Engl) 2019 Jun;132(12):1499-1501

Department of Obstetrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China.

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http://dx.doi.org/10.1097/CM9.0000000000000268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629321PMC
June 2019
7 Reads