1,916 results match your criteria Blount Disease


The development of a lifetime care model in comprehensive spina bifida care.

J Pediatr Rehabil Med 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.

Purpose: To describe the development and implementation of the Children's of Alabama (COA) Spina Bifida (SB) Lifetime-Care-Model, including standardized care protocols and transition plan.

Methods: In 2010, members of the pediatric team at COA began to evaluate limitations in access to care for patients with SB at various stages of life. Through clinic surveys, observations, and caregiver report, a Lifetime-Care-Model was developed and implemented. Read More

View Article
November 2018
1 Read

Evaluation of the Association Between Genetic Variants in Circadian Rhythm Genes and Posttraumatic Stress Symptoms Identifies a Potential Functional Allele in the Transcription Factor .

Front Psychiatry 2018 15;9:597. Epub 2018 Nov 15.

Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, United States.

Previous studies suggest that genetic variants within genes affecting the circadian rhythm influence the development of posttraumatic stress symptoms (PTSS). In the present study, we used data from three emergency care-based cohorts to search genetic variants in circadian pathway genes previously associated with neuropsychiatric disorders for variants that influence PTSS severity. The three cohorts used included a discovery cohort of African American men and women enrolled following motor vehicle collision ( = 907) and two replication cohorts: one of multi-ethnic women enrolled following sexual assault ( = 274) and one of multi-ethnic men and women enrolled following major thermal burn injury ( = 68). Read More

View Article
November 2018
1 Read

Percutaneous low-energy osteotomy in treatment of pathological coronal knee deformities in pediatrics.

J Pediatr Orthop B 2018 Nov 21. Epub 2018 Nov 21.

Department of Orthopaedic Surgery, Ain Shams University, Cairo, Egypt.

The aim of this study was to assess the safety and efficacy of percutaneous low-energy osteotomy and casting in treatment of pathological coronal knee deformities in children equal or younger than 6 years. A prospective nonrandomized case series study was conducted. A total of 62 (109 limbs) patients with pathological coronal knee deformities were treated by percutaneous low-energy osteotomy and casting and observed over 3-10 years. Read More

View Article
November 2018

Electromagnetic Navigation Bronchoscopy for Peripheral Pulmonary Lesions: One-Year Results of the Prospective, Multicenter NAVIGATE Study.

J Thorac Oncol 2018 Nov 23. Epub 2018 Nov 23.

Inova Health System, 2921 Telestar Court, Suite 140, Falls Church, VA 22043.

Introduction: Electromagnetic navigation bronchoscopy (ENB) is a minimally invasive technology that guides endoscopic tools to pulmonary lesions. ENB has been evaluated primarily in small, single-center studies; thus, the diagnostic yield in a generalizable setting is unknown.

Methods: NAVIGATE is a prospective, multicenter, cohort study that evaluated ENB using the superDimension™ navigation system. Read More

View Article
November 2018
8 Reads

Effects of Low Intensity Focused Ultrasound on Liposomes Containing Channel proteins.

Sci Rep 2018 Nov 22;8(1):17250. Epub 2018 Nov 22.

Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA.

The ability to reversibly and non-invasively modulate region-specific brain activity in vivo suggests Low Intensity Focused Ultrasound (LIFU) as potential therapeutics for neurological dysfunctions such as epilepsy and Parkinson's disease. While in vivo studies provide evidence of the bioeffects of LIFU on neuronal activity, they merely hint at potential mechanisms but do not fully explain how this technology achieves these effects. One potential hypothesis is that LIFU produces local membrane depolarization by mechanically perturbing the neuronal cell membrane, or activating channels or other proteins embedded in the membrane. Read More

View Article
November 2018
1 Read

Marijuana and Tobacco Coexposure in Hospitalized Children.

Pediatrics 2018 Dec;142(6)

Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: The impact of secondhand marijuana smoke exposure on children is unknown. New methods allow for the detection of marijuana smoke exposure in children.

Methods: We studied children who were hospitalized in Colorado and had a parent participating in a smoking cessation study; all children had urine samples remaining from the original study as well as consent for future research. Read More

View Article
December 2018
2 Reads

Contingency and determinism in evolution: Replaying life's tape.

Science 2018 11;362(6415)

Department of Biology, Washington University, St. Louis, MO 63130, USA.

Historical processes display some degree of "contingency," meaning their outcomes are sensitive to seemingly inconsequential events that can fundamentally change the future. Contingency is what makes historical outcomes unpredictable. Unlike many other natural phenomena, evolution is a historical process. Read More

View Article
November 2018

Novel compounds that specifically bind and modulate MscL: insights into channel gating mechanisms.

FASEB J 2018 Oct 25:fj201801628R. Epub 2018 Oct 25.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

The bacterial mechanosensitive channel of large conductance (MscL) normally functions as an emergency release valve discharging cytoplasmic solutes upon osmotic stress. Opening the large pore of MscL inappropriately is detrimental to the cell, and thus it has been speculated to be a potential antibiotic target. Although MscL is one of the best studied mechanosensitive channels, no chemical that influenced bacterial growth by modulating MscL is known. Read More

View Article
October 2018
3 Reads

The Role of Taylor Spatial Frame in the Treatment of Blount Disease.

Folia Med (Plovdiv) 2018 Jun;60(2):208-215

Pediatric Orthopaedics, Iaso Children's Hospital, Athens, Greece.

Background: Alteration of the posteromedial part of the proximal tibia is the main characteristic of Blount's disease and if left untreated, leg alignment and normal development of the lower limbs may be compromised.

Aim: To report treatment outcomes in children with Blount's disease using the Taylor Spatial Frame (TSF).

Materials And Methods: From January 2007 to December 2014, 16 young children (24 tibia) with a mean age of 7. Read More

View Article
June 2018
2 Reads

On the deformability of an empirical fitness landscape by microbial evolution.

Proc Natl Acad Sci U S A 2018 10 15;115(44):11286-11291. Epub 2018 Oct 15.

Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06511;

A fitness landscape is a map between the genotype and its reproductive success in a given environment. The topography of fitness landscapes largely governs adaptive dynamics, constraining evolutionary trajectories and the predictability of evolution. Theory suggests that this topography can be deformed by mutations that produce substantial changes to the environment. Read More

View Article
October 2018
4 Reads

No evidence of quantitative signal honesty across species of aposematic burnet moths (Lepidoptera: Zygaenidae).

J Evol Biol 2018 Oct 14. Epub 2018 Oct 14.

Centre for Ecology & Conservation, College of Life & Environmental Sciences, University of Exeter, Penryn, UK.

Many defended species use conspicuous visual warning signals to deter potential predators from attacking. Traditional theory holds that these signals should converge on similar forms, yet variation in visual traits and the levels of defensive chemicals is common, both within and between species. It is currently unclear how the strength of signals and potency of defences might be related: conflicting theories suggest that aposematic signals should be quantitatively honest, or, in contrast, that investment in one component should be prioritized over the other, while empirical tests have yielded contrasting results. Read More

View Article
October 2018

Reducing inequities in preventable neural tube defects: the critical and underutilized role of neurosurgical advocacy for folate fortification.

Neurosurg Focus 2018 Oct;45(4):E20

Department of Neurosurgery, University of Alabama at Birmingham, Alabama.

Neural tube defects (NTDs) are one of the greatest causes of childhood mortality and disability-adjusted life years worldwide. Global prevalence at birth is approximately 18.6 per 10,000 live births, with more than 300,000 infants with NTDs born every year. Read More

View Article
October 2018
2 Reads

Can Gartland II and III supracondylar humerus fractures be treated using Blount's method in the emergency room?

Orthop Traumatol Surg Res 2018 Nov 12;104(7):1079-1081. Epub 2018 Sep 12.

Service d'orthopédie pédiatrique, CHU de Lenval, hôpitaux pédiatriques de Nice, 57, avenue de la Californie, 06000 Nice, France. Electronic address:

Background: Studies have established that Blount's method is reliable for treating extension supracondylar fractures (SCFs) in paediatric patients. Reduction in the emergency room (ER) under procedural sedation followed by orthopaedic treatment is increasingly used for many fracture types. The primary objective of this study was to determine whether SCF reduction in the ER was feasible, by determining the failure rate. Read More

View Article
November 2018
3 Reads

Development of best practices to minimize wound complications after complex tethered spinal cord surgery: a modified Delphi study.

J Neurosurg Pediatr 2018 Sep 14:1-9. Epub 2018 Sep 14.

Department of Neurological Surgery, Columbia University Medical Center, New York, New York.

OBJECTIVE Complications after complex tethered spinal cord (cTSC) surgery include infections and cerebrospinal fluid (CSF) leaks. With little empirical evidence to guide management, there is variability in the interventions undertaken to limit complications. Expert-based best practices may improve the care of patients undergoing cTSC surgery. Read More

View Article
September 2018
5 Reads

Effects of supplementary feeding on interspecific dominance hierarchies in garden birds.

PLoS One 2018 5;13(9):e0202152. Epub 2018 Sep 5.

Centre for Ecology and Conservation, College of Life & Environmental Sciences, University of Exeter, Penryn Campus, Penryn, Cornwall, United Kingdom.

Individuals often differ in competitive ability, which can lead to the formation of a dominance hierarchy that governs differential access to resources. Previous studies of dominance have predominently focussed on within-species interactions, while the drivers of between-species competitive hierarchies are poorly understood. The increasing prevalence of predictable anthropogenic food subsidies, such as that provided by garden bird feeders, is likely to intensify between-species competition. Read More

View Article
September 2018
6 Reads

Health Problems and Burning Indoor Fuels.

Am J Respir Crit Care Med 2018 Sep;198(5):P9-P10

View Article
September 2018
7 Reads

Treated hydrocephalus in individuals with myelomeningocele in the National Spina Bifida Patient Registry.

J Neurosurg Pediatr 2018 Aug 24:1-6. Epub 2018 Aug 24.

Department of Neurosurgery, University of Alabama at Birmingham, Children's of Alabama, Birmingham.

OBJECTIVE Although the majority of patients with myelomeningocele have hydrocephalus, reported rates of hydrocephalus treatment vary widely. The purpose of this study was to determine the rate of surgical treatment for hydrocephalus in patients with myelomeningocele in the National Spina Bifida Patient Registry (NSBPR). In addition, the authors explored the variation in shunting rates across NSBPR institutions, examined the relationship between hydrocephalus, and the functional lesion level of the myelomeningocele, and evaluated for temporal trends in rates of treated hydrocephalus. Read More

View Article
August 2018
2 Reads

Decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry.

J Neurosurg Pediatr 2018 Aug 24:1-7. Epub 2018 Aug 24.

Department of Neurosurgery, University of Alabama at Birmingham, Children's of Alabama, Birmingham.

OBJECTIVE The purpose of this study was to determine the rate of decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry (NSBPR). In addition, the authors explored the variation in rates of Chiari II decompression across NSBPR institutions, examined the relationship between Chiari II decompression and functional lesion level of the myelomeningocele, age, and need for tracheostomy, and they evaluated for temporal trends in rates of Chiari II decompression. METHODS The authors queried the NSBPR to identify all individuals with myelomeningocele between 2009 and 2015. Read More

View Article
August 2018
3 Reads

Quantification of 19 Aldehydes in Human Serum by Headspace SPME/GC/High-Resolution Mass Spectrometry.

Environ Sci Technol 2018 Sep 6;52(18):10571-10579. Epub 2018 Sep 6.

Division of Laboratory Sciences, National Center for Environmental Health , Centers for Disease Control and Prevention , Atlanta , Georgia 30341 , United States.

Sources of human aldehyde exposure include food additives, combustion of organic matter (tobacco smoke), water disinfection byproducts via ozonation, and endogenous processes. Aldehydes are potentially carcinogenic and mutagenic, and chronic human aldehyde exposure has raised concerns about potential deleterious health effects. To aid investigations of human aldehyde exposure, we developed a novel method to measure 19 aldehydes released from Schiff base protein adducts in serum using controlled acid hydrolysis, solid-phase microextraction (SPME), gas chromatography (GC), and high-resolution mass spectrometry (HRMS). Read More

View Article
September 2018

Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch.

ACS Chem Biol 2018 Oct 20;13(10):2908-2919. Epub 2018 Sep 20.

Department of Chemistry and Biochemistry , University of Colorado , 596 UCB , Boulder , Colorado 80309 , United States.

The flavin mononucleotide (FMN) riboswitch is an emerging target for the development of novel RNA-targeting antibiotics. We previously discovered an FMN derivative, 5FDQD, that protects mice against diarrhea-causing Clostridium difficile bacteria. Here, we present the structure-based drug design strategy that led to the discovery of this fluoro-phenyl derivative with antibacterial properties. Read More

View Article
October 2018
9 Reads

Reply to Million et al.

Clin Infect Dis 2018 Nov;67(11):1799-1800

Edward Hines Jr. VA Hospital, Hines, Illinois.

View Article
November 2018
1 Read

Intensive prolonged exposure therapy for combat-related posttraumatic stress disorder: Design and methodology of a randomized clinical trial.

Contemp Clin Trials 2018 Sep 25;72:126-136. Epub 2018 Jul 25.

VA Boston Healthcare System, Boston, MA, USA; Boston University, Boston, MA, USA. Electronic address:

Combat-related posttraumatic stress disorder (PTSD) is the most common psychological health condition in military service members and veterans who have deployed to the combat theater since September 11, 2001. One of the highest research priorities for the Department of Defense and the Department of Veterans Affairs is to develop and evaluate the most efficient and efficacious treatments possible for combat-related PTSD. However, the treatment of combat-related PTSD in military service members and veterans has been significantly more challenging than the treatment of PTSD in civilians. Read More

View Article
September 2018
12 Reads
1.990 Impact Factor

Exposure to Perchlorate in Lactating Women and Its Associations With Newborn Thyroid Stimulating Hormone.

Front Endocrinol (Lausanne) 2018 3;9:348. Epub 2018 Jul 3.

Department of Medical Biochemistry, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Perchlorate, thiocyanate, and nitrate can block iodide transport at the sodium iodide symporter (NIS) and this can subsequently lead to decreased thyroid hormone production and hypothyroidism. NIS inhibitor exposure has been shown to reduce iodide uptake and thyroid hormone levels; therefore we hypothesized that maternal NIS inhibitor exposure will influence both maternal and newborn thyroid function. Spot urine samples were collected from 185 lactating mothers and evaluated for perchlorate, thiocyanate, and nitrate concentrations. Read More

View Article
July 2018
5 Reads

Building Trust through Lymphatic Filariasis Elimination: A Platform to Address Social Exclusion and Human Rights in the Dominican Republic.

Health Hum Rights 2018 Jun;20(1):41-52

Epidemiologist for Health Programs at The Carter Center, Atlanta, GA, USA.

Hispaniola, the Caribbean island that includes the countries of Haiti and the Dominican Republic (DR), accounts for 90% of lymphatic filariasis (LF) in the Americas. Both countries have committed to LF elimination by 2020. In the DR, LF occurs mainly in , or company towns that historically hosted migrant laborers from Haiti. Read More

View Article

Treatment failures and complications in patients with Blount disease treated with temporary hemiepiphysiodesis: a critical systematic literature review.

J Pediatr Orthop B 2018 Nov;27(6):522-529

Department of Orthopaedics, University Medical Center Hamburg-Eppendorf.

This systematic review sums up the state of knowledge about complications and reasons for failure when children with Blount disease are treated with temporary hemiepiphysiodesis. Twelve studies meet the inclusion criteria. The main reported obstacles were under correction and the poor predictability of the amount of correction that was obtainable. Read More

View Article
November 2018
19 Reads

Effects of winter food provisioning on the phenotypes of breeding blue tits.

Ecol Evol 2018 May 24;8(10):5059-5068. Epub 2018 Apr 24.

Centre for Ecology and Conservation College of Life & Environmental Sciences University of Exeter Penryn Cornwall UK.

Throughout the Western World, huge numbers of people regularly supply food for wild birds. However, evidence of negative impacts of winter feeding on future reproduction has highlighted a need to improve understanding of the underlying mechanisms shaping avian responses to supplementary food. Here, we test the possibility that carry-over effects are mediated via their impact on the phenotypes of breeding birds, either by influencing the phenotypic structure of populations through changes in winter survival and/or by more direct effects on the condition of breeding birds. Read More

View Article

Particle Shape Influences Settling and Sorting Behavior in Microfluidic Domains.

Sci Rep 2018 Jun 5;8(1):8583. Epub 2018 Jun 5.

Defense Intelligence Solutions Division, Southwest Research Institute, San Antonio, TX, 78238, USA.

We present a new numerical model to simulate settling trajectories of discretized individual or a mixture of particles of different geometrical shapes in a quiescent fluid and their flow trajectories in a flowing fluid. Simulations unveiled diverse particle settling trajectories as a function of their geometrical shape and density. The effects of the surface concavity of a boomerang particle and aspect ratio of a rectangular particle on the periodicity and amplitude of oscillations in their settling trajectories were numerically captured. Read More

View Article

Expression and Regulation of Deubiquitinase-Resistant, Unanchored Ubiquitin Chains in Drosophila.

Sci Rep 2018 May 31;8(1):8513. Epub 2018 May 31.

Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, USA.

The modifier protein, ubiquitin (Ub) regulates various cellular pathways by controlling the fate of substrates to which it is conjugated. Ub moieties are also conjugated to each other, forming chains of various topologies. In cells, poly-Ub is attached to proteins and also exists in unanchored form. Read More

View Article

Collaborative Method Performance Study of the Measurement of Nicotine, Its Metabolites, and Total Nicotine Equivalents in Human Urine.

Cancer Epidemiol Biomarkers Prev 2018 Sep 31;27(9):1083-1090. Epub 2018 May 31.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Biomarkers of tobacco exposure have a central role in studies of tobacco use and nicotine intake. The most significant exposure markers are nicotine itself and its metabolites in urine. Therefore, it is important to evaluate the performance of laboratories conducting these biomarker measurements. Read More

View Article
September 2018
6 Reads
1 Citation
4.120 Impact Factor

The impact of conversion to International Classification of Diseases, 10th revision (ICD-10) on an academic ophthalmology practice.

Clin Ophthalmol 2018 18;12:949-956. Epub 2018 May 18.

Department of Ophthalmology & Vision Sciences, University of California, Davis Medical Center, Sacramento, CA, USA.

Purpose: To determine the financial and clinical impact of conversion from International Classification of Disease, 9th revision (ICD-9) to ICD-10 coding.

Design: Retrospective, database study.

Materials And Methods: Monthly billing and coding data from 44,564 billable patient encounters at an academic ophthalmology practice were analyzed by subspecialty in the 1-year periods before (October 1, 2014, to September 30, 2015) and after (October 1, 2015, to September 30, 2016) conversion from ICD-9 to ICD-10. Read More

View Article
May 2018
1 Read

Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome.

Nat Commun 2018 05 22;9(1):1932. Epub 2018 May 22.

Imperial College Centre for Synthetic Biology, Imperial College London, London, SW7 2AZ, UK.

Synthetic biology tools, such as modular parts and combinatorial DNA assembly, are routinely used to optimise the productivity of heterologous metabolic pathways for biosynthesis or substrate utilisation, yet it is well established that host strain background is just as important for determining productivity. Here we report that in vivo combinatorial genomic rearrangement of Saccharomyces cerevisiae yeast with a synthetic chromosome V can rapidly generate new, improved host strains with genetic backgrounds favourable to diverse heterologous pathways, including those for violacein and penicillin biosynthesis and for xylose utilisation. We show how the modular rearrangement of synthetic chromosomes by SCRaMbLE can be easily determined using long-read nanopore sequencing and we explore experimental conditions that optimise diversification and screening. Read More

View Article
May 2018
3 Reads

Urinary metabolites of volatile organic compounds of infants in the neonatal intensive care unit.

Pediatr Res 2018 Jun 16;83(6):1158-1164. Epub 2018 May 16.

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland.

BackgroundPreterm infants (PTI) in the NICU are often placed in incubators that may increase their exposure to volatile organic chemicals (VOCs). To determine whether PTI in incubators have higher urinary concentrations of VOC metabolites compared with infants in cribs.MethodsUrine from 40 PTI in incubators and 40 infants in cribs was collected and analyzed for 28 urinary VOC biomarkers. Read More

View Article
June 2018
2 Reads

Sex differences but no evidence of quantitative honesty in the warning signals of six-spot burnet moths (Zygaena filipendulae L.).

Evolution 2018 May 16. Epub 2018 May 16.

Centre for Ecology and Conservation, College of Life and Environmental Sciences, University of Exeter, Penryn, Cornwall TR10 9FE, United Kingdom.

The distinctive black and red wing pattern of six-spot burnet moths (Zygaena filipendulae, L.) is a classic example of aposematism, advertising their potent cyanide-based defences. While such warning signals provide a qualitatively honest signal of unprofitability, the evidence for quantitative honesty, whereby variation in visual traits could provide accurate estimates of individual toxicity, is more equivocal. Read More

View Article
May 2018
3 Reads

Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.

N Engl J Med 2018 Jul 16;379(3):215-225. Epub 2018 May 16.

From the Dean's Office, Dell Medical School, University of Texas at Austin, Austin (S.C.J.); the Department of Neurology, University of California, San Francisco, San Francisco (J.D.E., M.F., A.S.K.); the Department of Emergency Medicine, University of Michigan, Ann Arbor (W.B.); the Division of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda (R.A.C.), and Emmes, Rockville (A.S.L.) - both in Maryland; and the Data Coordination Unit, Department of Public Health Sciences, Medical University of South Carolina, Charleston (J.J.E., Y.Y.P.).

Background: Combination antiplatelet therapy with clopidogrel and aspirin may reduce the rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient ischemic attack (TIA). A trial of combination antiplatelet therapy in a Chinese population has shown a reduction in the risk of recurrent stroke. We tested this combination in an international population. Read More

View Article
July 2018
1 Read

Chronic lithium treatment induces novel patterns of pendrin localization and expression.

Am J Physiol Renal Physiol 2018 Aug 18;315(2):F313-F322. Epub 2018 Apr 18.

Renal Division, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.

Prolonged lithium treatment is associated with various renal side effects and is known to induce inner medullary collecting duct (IMCD) remodeling. In animals treated with lithium, the fraction of intercalated cells (ICs), which are responsible for acid-base homeostasis, increases compared with renal principal cells (PCs). To investigate the intricacies of lithium-induced IMCD remodeling, male Sprague-Dawley rats were fed a lithium-enriched diet for 0,1, 2, 3, 6, 9, or 12 wk. Read More

View Article
August 2018
1 Read

Engineering a pH-Sensitive Liposomal MRI Agent by Modification of a Bacterial Channel.

Small 2018 May 11;14(19):e1704256. Epub 2018 Apr 11.

Department of Physiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

MscL is a bacterial mechanosensitive channel that serves as a cellular emergency release valve, protecting the cell from lysis upon a drop in external osmolarity. The channel has an extremely large pore (30 Å) and can be purified and reconstituted into artificial membranes. Moreover, MscL is modified to open in response to alternative external stimuli including changes in pH. Read More

View Article

Multimethod Assessment of Medication Nonadherence and Barriers in Adolescents and Young Adults With Solid Organ Transplants.

J Pediatr Psychol 2018 Aug;43(7):789-799

University of Georgia.

Objective: To (a) examine levels of medication nonadherence in adolescent and young adult (AYA) solid organ transplant recipients based on AYA- and caregiver proxy-reported nonadherence to different medication types and the medication-level variability index (MLVI) for tacrolimus, and (b) examine associations of adherence barriers and AYA and caregiver emotional distress symptoms with reported nonadherence and the MLVI.

Method: The sample included 47 AYAs (M age = 16.67 years, SD = 1. Read More

View Article
August 2018
15 Reads

Digital poly-victimization: The increasing importance of online crime and harassment to the burden of victimization.

J Trauma Dissociation 2018 May-Jun;19(3):382-398

a Appalachian Center for Resilience Research & Department of Psychology , University of the South , Monteagle , TN , USA.

Many forms of victimization, including bullying and property crime, are increasingly moving online, but most studies of poly-victimization still primarily focus on in-person crime and violence. Few studies have examined the importance of incorporating technology-based victimizations for assessing the true burden of violence. The purpose of this study is to explore whether digital poly-victimization contributes to post-traumatic stress and anxiety/dysphoria symptoms after controlling for in-person poly-victimization. Read More

View Article
October 2018

UPLC-ESI-MS/MS method for the quantitative measurement of aliphatic diamines, trimethylamine N-oxide, and β-methylamino-l-alanine in human urine.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Apr 2;1083:86-92. Epub 2018 Mar 2.

Centers for Disease Control and Prevention, Division of Laboratory Sciences, Tobacco and Volatiles Branch, Atlanta, GA 30341, United States.

This work describes a quantitative high-throughput analytical method for the simultaneous measurement of small aliphatic nitrogenous biomarkers, i.e., 1,6-hexamethylenediamine (HDA), isophoronediamine (IPDA), β-methylamino-l-alanine (BMAA), and trimethylamine N-oxide (TMAO), in human urine. Read More

View Article
April 2018
3 Reads

Effects of an early-life paraquat exposure on adult resistance to oxidative stress, plumage colour and sperm performance in a wild bird.

J Anim Ecol 2018 Jul 6;87(4):1137-1148. Epub 2018 Apr 6.

Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland.

Early-life stressful conditions can shape individual phenotypes and ultimately influence fitness. Oxidative stress is a pervasive threat that affects many fitness-related traits and can modulate life-history trade-offs. Yet, the extent to which exposure to oxidative stress during early life can have long-lasting effects on key fitness-related traits remains to be elucidated, particularly in natural populations of vertebrates. Read More

View Article
July 2018
2 Reads

Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability.

Cell 2018 Mar;173(1):166-180.e14

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Center for Neuroengineering, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA; Duke Institute for Brain Sciences, Duke University Medical Center, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 22208, USA. Electronic address:

Brain-wide fluctuations in local field potential oscillations reflect emergent network-level signals that mediate behavior. Cracking the code whereby these oscillations coordinate in time and space (spatiotemporal dynamics) to represent complex behaviors would provide fundamental insights into how the brain signals emotional pathology. Using machine learning, we discover a spatiotemporal dynamic network that predicts the emergence of major depressive disorder (MDD)-related behavioral dysfunction in mice subjected to chronic social defeat stress. Read More

View Article
March 2018
37 Reads
32.240 Impact Factor

Blount disease.

Authors:
Marc Janoyer

Orthop Traumatol Surg Res 2018 Feb 23. Epub 2018 Feb 23.

Service de chirurgie infantile, CHU de Martinique, Maison de la femme de la mère et de l'enfant, boîte postale 632, 97261 Fort-de-France cedex, Martinique. Electronic address:

Blount disease is an asymmetrical disorder of proximal tibial growth that produces a three-dimensional deformity. Tibia vara is the main component of the deformity. Blount disease exists as two clinical variants, infantile or early-onset, and adolescent or late-onset, defined based on whether the first manifestations develop before or after 10 years of age. Read More

View Article
February 2018
13 Reads

Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment.

Clin Exp Nephrol 2018 Aug 16;22(4):906-916. Epub 2018 Feb 16.

Section of Nephrology, Yale University School of Medicine, New Haven, CT, 06510, USA.

Background: Semaphorin 7A (SEMA7A) is an immunomodulating protein implicated in lung and liver fibrosis. In autosomal-dominant polycystic kidney disease (ADPKD), the progressive expansion of renal cysts, inflammation, and subsequent renal fibrosis leads to end-stage renal disease (ESRD). SEMA7A may play a role in renal fibrosis and in ADPKD. Read More

View Article
August 2018
1 Read

Electrode quenching control for highly efficient CsPbBr perovskite light-emitting diodes via surface plasmon resonance and enhanced hole injection by Au nanoparticles.

Nanotechnology 2018 Apr 13;29(17):175203. Epub 2018 Feb 13.

School of Physical Science and Technology, MOE Key Laboratory on Luminescence and Real-Time Analysis, Southwest University, Chongqing 400715, People's Republic of China.

Compared to organic-inorganic hybrid metal halide perovskites, all-inorganic cesium lead halides (e.g, CsPbBr) hold greater promise in being emissive materials for light-emitting diodes owing to their superior optoelectronic properties as well as their higher stabilities. However, there is still considerable potential for breakthroughs in the current efficiency of CsPbBr perovskite light-emitting diodes (PeLEDs). Read More

View Article
April 2018
10 Reads

Relations between Positive Temperament, Substance Use, and Internalizing Problems among Adolescents and Young Adults with and without Medical Conditions.

Subst Use Misuse 2018 Aug 9;53(10):1715-1725. Epub 2018 Feb 9.

a Department of Psychology , University of Georgia , Athens , Georgia , USA.

Background: Substance use problems are prevalent during emerging adulthood and may be particularly harmful for individuals with medical conditions. Understanding the role of positive temperament in substance use for adolescents and young adults (AYAs) may facilitate the identification of intervention and prevention targets given the complex relations between positive emotions and substance use.

Objective: To examine whether components of positive temperament differentially relate to substance use in a sample of AYAs with and without medical conditions. Read More

View Article
August 2018
1 Read
1.230 Impact Factor

Crotonaldehyde exposure in U.S. tobacco smokers and nonsmokers: NHANES 2005-2006 and 2011-2012.

Environ Res 2018 May 3;163:1-9. Epub 2018 Feb 3.

Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention Atlanta, GA 30341, USA.

Introduction: Crotonaldehyde is an α,β-unsaturated carbonyl compound that is a potent eye, respiratory, and skin irritant. Crotonaldehyde is a major constituent of tobacco smoke and its exposure can be quantified using its urinary metabolite N-acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine (HPMM). A large-scale biomonitoring study is needed to determine HPMM levels, as a measure of crotonaldehyde exposure, in the general U. Read More

View Article
May 2018
3 Reads

Update on treatment of adolescent Blount disease.

Curr Opin Pediatr 2018 02;30(1):71-77

Advanced Bone Reconstruction Surgery, Hospital San Juan de Dios y Complejo Hospitalario de Navarra, Pamplona, Spain.

Purpose Of Review: Treatments available to correct adolescent Blount disease deformities differ in terms of features, advantages, and disadvantages. Each is indicated, therefore, for different scenarios of severity, physeal condition, and maturity. The purpose of this review is to update basic concepts, surgical treatments, and controversies concerning this disorder. Read More

View Article
February 2018
11 Reads

The changing landscape of Lynch syndrome due to PMS2 mutations.

Authors:
J Blount A Prakash

Clin Genet 2018 Jul 15;94(1):61-69. Epub 2018 Mar 15.

Mitchell Cancer Institute, The University of South Alabama, Mobile, Alabama.

DNA repair pathways are essential for cellular survival as our DNA is constantly under assault from both exogenous and endogenous DNA damaging agents. Five major mammalian DNA repair pathways exist within a cell to maintain genomic integrity. Of these, the DNA mismatch repair (MMR) pathway is highly conserved among species and is well documented in bacteria. Read More

View Article
July 2018
7 Reads

Drug Monographs: Avelumab and Ribociclib.

Hosp Pharm 2017 Jul 17;52(7):459-463. Epub 2017 Jul 17.

Oncology Pharmacy Services, Inc, Arlington, VA, USA.

The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Read More

View Article