Safety of intravenous tranexamic acid in patients undergoing majororthopaedic surgery: a meta-analysis of randomised controlled trials.
- Massimo Franchini,
- Carlo Mengoli,
- Marco Marietta,
- Giuseppe Marano,
- Stefania Vaglio,
- Simonetta Pupella,
- Pier Mannuccio Mannucci,
- Giancarlo M Liumbruno
Blood Transfus 2018 Jan;16(1):36-43
Italian National Blood Centre, National Institute of Health, Rome, Italy.
Among the various pharmacological options to decrease peri-operative bleeding, tranexamic acid appears to be one of the most interesting. Several trials have consistently documented the efficacy of this synthetic drug in reducing the risk of blood loss and the need for allogeneic blood transfusion in patients undergoing total hip and knee arthroplasty. The safety of intravenous tranexamic acid in major orthopaedic surgery, particularly regarding the risk of venous thromboembolism, was systematically analysed in this review. Read More