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    1099 results match your criteria Blood transfusion = Trasfusione del sangue[Journal]

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    Position Paper on laboratory testing for patients on direct oral anticoagulants. A Consensus Document from the SISET, FCSA, SIBioC and SIPMeL.
    Blood Transfus 2017 Sep 13:1-9. Epub 2017 Sep 13.
    Department of Laboratory Medicine, Haemostasis and Thrombosis Centre, Hospital Institutes, Cremona, Italy.
    Although direct oral anticoagulants (DOAC) do not require dose-adjustment on the basis of laboratory test results, the measurement of their anticoagulant effect is useful in special situations. This position paper issued by the Italian Scientific Societies that are mainly involved in the management of patients on DOAC is aimed at providing guidance to care-givers on which tests should be used and the situations in which testing is useful. The guidance is based on the data from the literature so far available and/or on consensus among experts. Read More

    Cell salvage for postpartum haemorrhage during vaginal delivery: a case series.
    Blood Transfus 2017 Sep 29:1-4. Epub 2017 Sep 29.
    Department of Anesthesiology, Magee-Women's Hospital of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.
    Background: The safety and effectiveness of cell salvage for vaginal delivery is unknown. This case series aimed to assess the utility and adverse events related to the use of cell salvage for maternal haemorrhage during vaginal delivery.

    Materials And Methods: A cohort study design was chosen, focused on postpartum haemorrhages that occurred after vaginal delivery for which cell salvage equipment was requested to be set up in the labour and delivery room outside of a sterile operating room environment. Read More

    Characteristics of thawed pooled cryoprecipitate stored at refrigerated temperature for 24 hours.
    Blood Transfus 2017 Oct 30:1-4. Epub 2017 Oct 30.
    Department of Pathology, CHI St. Luke's Health - Baylor St. Luke's Medical Center, Baylor College of Medicine, Houston, TX, United States of America.
    Background: The need for thawed cryoprecipitate is growing. However, according to current guidelines, the shelf-life of pooled thawed cryoprecipitate at room temperature is limited because of possible bacterial contamination and loss of clotting factor activity. Here we assessed microbial growth and retention of clotting activity in cryoprecipitate stored at 4 °C after thawing to see whether its shelf life could be safely extended. Read More

    Current misconceptions in diagnosis and management of iron deficiency.
    Blood Transfus 2017 Sep;15(5):422-437
    Georgetown University School of Medicine, Washington, DC, United States of America.
    The prevention and treatment of iron deficiency is a major public health goal. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product which meets the needs of the patient. However, there are a number of non-evidence-based misconceptions regarding the diagnosis and management of iron deficiency, with or without anaemia, as well as inconsistency of terminology and lack of clear guidance on clinical pathways. Read More

    The role of recombinant activated factor VII in the haematological management of elective orthopaedic surgery in haemophilia A patients with inhibitors.
    Blood Transfus 2017 Sep 16;15(5):478-486. Epub 2017 May 16.
    Centre for Bleeding Disorders and Coagulation, Department of Oncology, "Careggi" University Hospital, Florence, Italy.
    The clinical profile and expectations of haemophilic patients with inhibitors have changed over the last three decades, mainly because of the prolongation of life-expectancy, often resulting in an increase of the orthopaedic burden. Recombinant activated factor VII (rFVIIa) is the most frequently used bypassing agent in haemophilia patients with inhibitors during elective orthopaedic surgery. For nearly 30 years, rFVIIa has been successfully used to control haemostasis in several major and minor surgical procedures. Read More

    High-titre inhibitors in previously untreated patients with severe haemophilia A receiving recombinant or plasma-derived factor VIII: a budget-impact analysis.
    Blood Transfus 2017 May 15:1-7. Epub 2017 May 15.
    "A. Bianchi Bonomi" Haemophilia and Thrombosis Centre, "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", Milan, Italy.

    Paediatric venous thromboembolism: a report from the Italian Registry of Thrombosis in Children (RITI).
    Blood Transfus 2017 Jun 30:1-8. Epub 2017 Jun 30.
    Department of Medicine, Thrombotic and Haemorrhagic Diseases Unit, University of Padua Medical School, Padua, Italy.
    Background: The Italian Registry of Thrombosis in Children (RITI) was established by a multidisciplinary team with the aims of improving knowledge about neonatal and paediatric thrombotic events in Italy and providing a preliminary source of data for the future development of specific clinical trials and diagnostic-therapeutic protocols.

    Materials And Methods: We analysed the subset of RITI data concerning paediatric systemic venous thromboembolic events that occurred between January 2007 and June 2013.

    Results: Eighty-five deep venous thromboses and seven pulmonary emboli were registered in the RITI. Read More

    Influence of red blood cell-derived microparticles upon vasoregulation.
    Blood Transfus 2017 Oct 15;15(6):522-534. Epub 2017 May 15.
    Department of Pediatrics, Washington University, St. Louis, MO, United States of America.
    Here we review recent data and the evolving understanding of the role of red blood cell-derived microparticles (RMPs) in normal physiology and in disease progression. Microparticles (MPs) are small membrane vesicles derived from various parent cell types. MPs are produced in response to a variety of stimuli through several cytoskeletal and membrane phospholipid changes. Read More

    Washing in hypotonic saline reduces the fraction of irreversibly-damaged cells in stored blood: a proof-of-concept study.
    Blood Transfus 2017 Sep 11;15(5):463-471. Epub 2017 May 11.
    Department of Biomedical Engineering, University of Houston, TX, United States of America.
    Background: During hypothermic storage, a substantial fraction of red blood cells (RBCs) transforms from flexible discocytes to rigid sphero-echinocytes and spherocytes. Infusion of these irreversibly-damaged cells into the recipient during transfusion serves no therapeutic purpose and may contribute to adverse outcomes in some patients. In this proof-of-concept study we describe the use of hypotonic washing for selective removal of the irreversibly-damaged cells from stored blood. Read More

    Individual, contextual and network characteristics of blood donors and non-donors: a systematic review of recent literature.
    Blood Transfus 2017 Sep 13;15(5):382-397. Epub 2017 Jun 13.
    Department of Donor Studies, Sanquin Research, Vrije Universiteit, the Netherlands.
    Background: The ageing population and recent migration flows may negatively affect the blood supply in the long term, increasing the importance of targeted recruitment and retention strategies to address donors. This review sought to identify individual, network and contextual characteristics related to blood donor status and behaviour, to systematically discuss differences between study results, and to identify possible factors to target in recruitment and retention efforts.

    Methods: The systematic review was conducted in accordance with a predefined PROSPERO protocol (CRD42016039591). Read More

    Use of fresh-frozen plasma in 2012 at the Fondazione Ca' Granda Hospital of Milan: assessment of appropriateness using record linkage techniques applied to data routinely recorded in various hospital information systems.
    Blood Transfus 2017 Jun 19:1-9. Epub 2017 Jun 19.
    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
    Background: The Quality Unit of a research and teaching hospital in Milan assessed the increased clinical use of fresh-frozen plasma in patients treated during 2012 in order to evaluate the appropriateness of this use.

    Materials And Methods: For each patient in the study, a pathology profile was generated by means of record linkage techniques involving data collected through different information systems. Patients' information was combined using the patient identifier key generating pathology profiles exported to an Excel file. Read More

    Enhanced opsonisation of Rhesus D-positive human red blood cells by recombinant polymeric immunoglobulin G anti-G antibodies.
    Blood Transfus 2017 May 30:1-9. Epub 2017 May 30.
    Cellular and Molecular Pathology Laboratory, Experimental Medicine Centre, Venezuelan Institute of Scientific Investigation (IVIC), Caracas, Venezuela.
    Background: Anti-RhD antibodies (anti-D) are important in the prophylaxis of haemolytic disease of the foetus and newborn (HDFN) due to RhD incompatibility. Current preparations of anti-D are sourced from hyperimmune human plasma, so its production carries a risk of disease and is dependent on donor availability. Despite the efforts to develop a monoclonal preparation with similar prophylactic properties to the plasma-derived anti-D, no such antibody is yet available. Read More

    Improving the safety of whole blood-derived transfusion products with a riboflavin-based pathogen reduction technology.
    Blood Transfus 2017 Jul 11;15(4):357-364. Epub 2017 May 11.
    Terumo BCT Europe N.V., Zaventem, Belgium.
    Worldwide safety of blood has been positively impacted by technological, economic and social improvements; nevertheless, growing socio-political changes of contemporary society together with environmental changes challenge the practice of blood transfusion with a continuous source of unforeseeable threats with the emergence and re-emergence of blood-borne pathogens. Pathogen reduction (PR) is a proactive strategy to mitigate the risk of transfusion-transmitted infections. PR technologies for the treatment of single plasma units and platelet concentrates are commercially available and have been successfully implemented in more than 2 dozen countries worldwide. Read More

    The use of fibrinogen concentrate for the management of trauma-related bleeding: a systematic review and meta-analysis.
    Blood Transfus 2017 Jul;15(4):318-324
    Italian National Blood Centre, National Institute of Health, Rome, Italy.
    Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in this review. A systematic search of the literature identified six retrospective studies and one prospective one, involving 1,650 trauma patients. Read More

    Red blood cell transfusion policy: a critical literature review.
    Blood Transfus 2017 Jul;15(4):307-317
    Italian National Blood Centre, National Institute of Health, Rome, Italy.
    The issue of the most appropriate red blood cell transfusion policy has been addressed by a number of randomised controlled trials, conducted over the last decades, comparing the effects on patients' outcome of restrictive blood transfusion strategies (transfusing when the haemoglobin concentration is less than 7 g/dL to 8 g/dL) vs more liberal ones (transfusing when the haemoglobin concentration is less than 9 g/dL to 10 g/dL) in a variety of clinical settings. In parallel, various systematic reviews and meta-analyses have tried to perform pooled analyses of the data from these randomised controlled trials and their results have been utilised by scientific societies to provide recommendations and guidelines on red blood cell transfusion thresholds. All these aspects will be critically discussed in this narrative review. Read More


    Red blood cells ageing markers: a multi-parametric analysis.
    Blood Transfus 2017 May;15(3):239-248
    Blood Products Research Laboratory, Interregional Blood Transfusion SRC, Epalinges, Switzerland.
    Background: Red blood cells collected in citrate-phosphate-dextrose can be stored for up to 42 days at 4 °C in saline-adenine-glucose-mannitol additive solution. During this controlled, but nevertheless artificial, ex vivo ageing, red blood cells accumulate lesions that can be reversible or irreversible upon transfusion. The aim of the present study is to follow several parameters reflecting cell metabolism, antioxidant defences, morphology and membrane dynamics during storage. Read More

    Acetylcholinesterase provides new insights into red blood cell ageing in vivo and in vitro.
    Blood Transfus 2017 May;15(3):232-238
    Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
    Background: During its 120 days sojourn in the circulation, the red blood cell (RBC) remodels its membrane. Acetylcholinesterase (AChE) is a glycosylphosphatidylinositol (GPI)-linked enzyme that may serve as a marker for membrane processes occurring this ageing-associated remodelling process.

    Materials And Methods: Expression and enzymatic activity of AChE were determined on RBCs of various ages, as obtained by separation based on volume and density (ageing in vivo), and on RBCs of various times of storage in blood bank conditions (ageing in vitro), as well as on RBC-derived vesicles. Read More

    Red blood cell storage time and transfusion: current practice, concerns and future perspectives.
    Blood Transfus 2017 May;15(3):222-231
    Department of Hematology, "Instituto de Investigación Sanitaria San Carlos" (IdISSC), "Hospital Clínico San Carlos", Madrid, Spain.
    Red blood cells (RBCs) units are the most requested transfusion product worldwide. Indications for transfusion include symptomatic anaemia, acute sickle cell crisis, and acute blood loss of more than 30% of the blood volume, with the aim of restoring tissue oxygen delivery. However, stored RBCs from donors are not a qualitative equal product, and, in many ways, this is a matter of concern in the transfusion practice. Read More

    The potential adverse effects of haemolysis.
    Blood Transfus 2017 May;15(3):218-221
    Department of Anaesthesia and Critical Care, "Fondazione IRCCS Istituto Nazionale dei Tumori", Milan, Italy.
    Haemolysis occurs in many haematologic and non-haematologic diseases. Transfusion of packed red blood cells (pRBCs) can result in intravascular haemolysis, in which the RBCs are destroyed within the circulation, and extravascular haemolysis, in which RBCs are phagocytosed in the monocyte-macrophage system. This happens especially after RBCs have been stored under refrigerated conditions for long periods. Read More

    Blood donor deferral policies across Europe and characteristics of men who have sex with men screened for human immunodeficiency virus in blood establishments: data from the European Men-who-have-sex-with-men Internet Survey (EMIS).
    Blood Transfus 2017 Mar 23:1-10. Epub 2017 Mar 23.
    Division for HIV/AIDS, STI and Blood-borne Infections, Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
    Background: The predominant mode of transmission of human immunodeficiency virus (HIV) in Europe is male-to-male transmission. Men who have sex with men (MSM) are deferred from donating blood in many countries, but nevertheless do donate blood. Based on data from 34 countries, we estimated the proportion of MSM screened for HIV in the context of a blood donation and identified individual factors associated with this HIV screening in order to propose possible public health interventions. Read More

    Quality assessment and transfusion efficacy of buffy coat-derived platelet concentrates washed with platelet additive solution.
    Blood Transfus 2017 Apr 13:1-6. Epub 2017 Apr 13.
    Haematology and Medical Oncology Service, Morales Meseguer University Hospital, Regional Blood Donation Centre, University of Murcia, IMIB-Arrixaca, CIBERER, Murcia, Spain.
    Background: Transfusion of washed platelet concentrates (W-PC) is recommended for some patients, such as those who have had previous severe allergic transfusion reactions. However, we still lack a standardised method for preparing these products. Here, we assessed the effect of a manual washing procedure on in vitro platelet quality and on the transfusion efficacy of W-PCs. Read More

    A cost analysis of public cord blood banks belonging to the Italian Cord Blood Network.
    Blood Transfus 2017 Apr 13:1-11. Epub 2017 Apr 13.
    Italian National Blood Centre, National Institute of Health, Rome, Italy.
    Background: Public cord blood banking is currently managed in Italy by a network of 19 regional cord blood banks coordinated by the National Blood Centre and the National Transplant Centre. A cost analysis was carried out within the Italian network to determine the relationship between cost of cord blood collection and banking and size of the bank inventory, which ranged from 106 to 9,341 units on December 31(st), 2012.

    Materials And Methods: The 19 banks were invited to report costs incurred in 2012 related to cord blood unit collection, transportation, biological validation, characterisation, manipulation, cryopreservation, storage, data management, and general costs. Read More

    Prevention of red cell storage lesion: a comparison of five different additive solutions.
    Blood Transfus 2017 Sep 10;15(5):456-462. Epub 2017 Apr 10.
    Sanquin Blood Bank, Department Product and Process Development, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
    Background: In Europe, red cell concentrates (RCC) are usually stored in SAGM (saline-adenine-glucose-mannitol). During storage, in vitro red cell quality declines, including lowered energy status and increased cell lysis. Recently, several additive solutions (ASs), designed to diminish the decline in in vitro quality during storage, have been developed. Read More

    Purinergic control of red blood cell metabolism: novel strategies to improve red cell storage quality.
    Blood Transfus 2017 Oct 12;15(6):535-542. Epub 2017 Apr 12.
    Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX.
    Transfusion of stored blood is regarded as one of the great advances in modern medicine. However, during storage in the blood bank, red blood cells (RBCs) undergo a series of biochemical and biomechanical changes that affect cell morphology and physiology and potentially impair transfusion safety and efficacy. Despite reassuring evidence from clinical trials, it is universally accepted that the storage lesion(s) results in the altered physiology of long-stored RBCs and helps explain the rapid clearance of up to one-fourth of long-stored RBCs from the recipient's bloodstream at 24 hours after administration. Read More

    Haemolysis, pure red cell aplasia and red cell antibody formation associated with major and bidirectional ABO incompatible haematopoietic stem cell transplantation.
    Blood Transfus 2017 Apr 19:1-8. Epub 2017 Apr 19.
    Department of Internal Medicine, Division of Haematology, University Hospital Centre Zagreb, Zagreb, Croatia.
    Background: Acute and delayed haemolysis, alloimmunisation and pure red cell aplasia (PRCA) are potential complications after ABO incompatible haematopoietic stem cell transplantation (HSCT). The aims of this study were to investigate acute and delayed red blood cell (RBC) antibody-associated complications, including haemolysis, PRCA and alloimmunisation in major and bidirectional ABO incompatible HSCT.

    Materials And Methods: We retrospectively examined the transplant courses of 36 recipients of bone marrow or peripheral blood stem cells from ABO incompatible donors and evaluated the current practice of performing plasmapheresis in patients with higher isoagglutinin titres. Read More

    Mild-to-moderate foeto-maternal haemorrhage in the third trimester and at term of pregnancy: quantitative determination and clinical-diagnostic evaluation.
    Blood Transfus 2017 Apr 19:1-5. Epub 2017 Apr 19.
    Obstetric and Gynaecology Department, "IRCCS Policlinico S. Matteo", Pavia, Italy.
    Background: Foeto-maternal haemorrhage (FMH), a gestational event that occurs before or during delivery, consists of a loss of foetal blood into the maternal circulation. FMH occurs more frequently during the third trimester or labour both in normal and complicated pregnancies. In the case of alloimmunisation, the maternal immunological response and the severity of the resulting foetal or neonatal disease depend on the amount of foetal blood that passes into the maternal circulation. Read More

    Strategies for reducing the risk of transfusion-transmitted leishmaniasis in an area endemic for Leishmania infantum: a patient- and donor-targeted approach.
    Blood Transfus 2017 Mar 15:1-8. Epub 2017 Mar 15.
    Parasitology Laboratory, Faculty of Pharmacology, University of Barcelona, Barcelona, Spain.
    Background: In the Balearic Islands, as in other areas of the Mediterranean basin, there is a significant proportion of asymptomatic Leishmania (L.) infantum-infected blood donors, who may represent an important threat to transfusion safety. The Balearic Islands blood bank, located in an area endemic for L. Read More

    Effect of storage period of red blood cell suspensions on helper T-cell subpopulations.
    Blood Transfus 2017 Mar 15:1-11. Epub 2017 Mar 15.
    Department of Immunology, Institute of Health Sciences, Uludag University, Bursa, Turkey.
    Background: The aim of this study was to investigate the immunological alterations that occur during the storage of erythrocyte suspensions which may lead to transfusion-related immunomodulation following allogeneic blood transfusion.

    Materials And Methods: One part of the erythrocyte suspensions obtained from donors was leucoreduced while the other part was not. The leucoreduced (LR) and non-leucoreduced (NL) erythrocyte suspensions were then further divided into three equal amounts which were stored for 0, 21 or 42 days prior to measurements, by enzyme-linked immunosorbent assays, of cytokine levels in their supernatants. Read More

    Towards pathogen inactivation of red blood cells and whole blood targeting viral DNA/RNA: design, technologies, and future prospects for developing countries.
    Blood Transfus 2017 Oct 13;15(6):512-521. Epub 2017 Apr 13.
    International PhD Program of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taiwan.
    Over 110 million units of blood are collected yearly. The need for blood products is greater in developing countries, but so is the risk of contracting a transfusion-transmitted infection. Without efficient donor screening/viral testing and validated pathogen inactivation technology, the risk of transfusion-transmitted infections correlates with the infection rate of the donor population. Read More

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