524 results match your criteria Blood research[Journal]


Chronicles of blood morphology associated with steroid use.

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Blood Res 2020 Jun;55(2):128

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http://dx.doi.org/10.5045/br.2020.2019065DOI Listing

An interesting story of a clone.

Blood Res 2020 Jun;55(2):115-117

Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.5045/br.2020.2020012DOI Listing

Immune checkpoint inhibitors in patients with pretreated HodgkinÊs lymphoma: a Korean single-center, retrospective study.

Blood Res 2020 Jun;55(2):85-90

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Immune checkpoint inhibitors have demonstrated efficacy in the treatment of classical Hodgkin's lymphoma (cHL). We analyzed the efficacy and safety of pembrolizumab or nivolumab in patients with pretreated cHL.

Methods: Clinical data from the cancer chemotherapy registry of Samsung Medical Center were retrospectively analyzed to study patients with cHL treated with pembrolizumab or nivolumab between Oct 2015 and Dec 2018. Read More

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http://dx.doi.org/10.5045/br.2020.2020014DOI Listing

Coronavirus disease-19 and its hematological manifestations.

Blood Res 2020 Jun;55(2):71-74

Brain Korea 21 Plus Project, Chonnam National University Medical School, Gwangju, Korea.

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http://dx.doi.org/10.5045/br.2020.2020121DOI Listing

Adult T-cell leukemia/lymphoma and Glucose-6-phosphate dehydrogenase deficiency rapidly diagnosed through blood smear examination.

Blood Res 2020 Jun;55(2):76

Laboratoire d'hématologie, Centre de Biologie Pathologie, Centre Hospitalier Régional Universitaire de Lille, Lille, France.

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http://dx.doi.org/10.5045/br.2020.2020060DOI Listing

Response of multifocal acquired demyelinating sensorimotor neuropathy associated with atypical chronic lymphocytic leukemia to rituximab therapy.

Blood Res 2020 Jun;55(2):117-120

Department of Haematology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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http://dx.doi.org/10.5045/br.2020.2020047DOI Listing

Natural soluble human leukocyte antigen class I in donor serum neutralizes donor-specific HLA alloantibodies in recipient serum.

Blood Res 2020 Jun;55(2):91-98

Departments of Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.

Background: Human leukocyte antigen (HLA) molecules are cell-bound but can be identified in a soluble form. These soluble HLA (sHLA) molecules have an immunomodulatory function. We investigated whether natural sHLA in donor serum can neutralize donor-specific HLA alloantibodies (DSAs) in recipient serum. Read More

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http://dx.doi.org/10.5045/br.2020.2020031DOI Listing

Pulmonary hypertension in patients with Philadelphia-negative myeloproliferative neoplasms: a single-center retrospective analysis of 225 patients.

Blood Res 2020 Jun;55(2):77-84

Division of Hematology/Oncology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.

Background: The prevalence of pulmonary hypertension (PH) in myeloproliferative neoplasms (MPNs) varies among studies. We analyzed the prevalence of PH in Korean patients with Philadelphia-negative (Ph-) MPNs.

Methods: Medical records of patients with Ph- MPNs [essential thrombocythemia (ET), polycythemia vera (PV), or primary myelofibrosis (PMF)] visiting a single hospital between 1993 and 2019 were reviewed retrospectively. Read More

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http://dx.doi.org/10.5045/br.2020.2020001DOI Listing

Atypical presentation of hairy cell leukemia: a report and comprehensive review.

Blood Res 2020 Jun;55(2):123-127

Departments of Pathology and Laboratory Medicine, IMS and Sum Hospital, S'O'A Deemed to be University, Bhubaneswar, India.

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http://dx.doi.org/10.5045/br.2020.2020069DOI Listing

Impact of using genotyping to predict SERF negative phenotype in Thai blood donor populations.

Blood Res 2020 Jun;55(2):107-111

National Blood Centre, Thai Red Cross Society, Bangkok, Thailand.

Background: SERF(+) is a high prevalence antigen in the Cromer blood group system that is encoded by a allele. The SERF(-) on red cells is caused by a single nucleotide variation, c.647C>T, in exon 5 of the gene. Read More

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http://dx.doi.org/10.5045/br.2020.2020042DOI Listing

Apparent diffusion coefficient as a valuable quantitative parameter for predicting clinical outcomes in patients with newly diagnosed primary CNS lymphoma.

Blood Res 2020 Jun;55(2):99-106

Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.

Background: This study attempted to identify novel prognostic factors in patients with newly diagnosed primary central nervous system lymphoma (PCNSL) using magnetic resonance imaging (MRI).

Methods: We retrospectively evaluated 67 patients diagnosed with central nervous system (CNS) tumors. The enrollment criteria were as follows: i) pathologic diagnosis of CNS lymphoma, ii) no evidence of systemic involvement, iii) no evidence of human immunodeficiency virus-1 infection or other immunodeficiencies, and iv) MRI scans available at diagnosis. Read More

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http://dx.doi.org/10.5045/br.2020.2020032DOI Listing

Large granular lymphocytes (LGL) in primary Sjögren syndrome (pSS): immunophenotype and review on the pathological role of T cells in pSS.

Blood Res 2020 Jun;55(2):120-123

Department of Clinical and Experimental Medicine, Section of Haematology, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.5045/br.2020.2020052DOI Listing

Chronic phase of chronic myeloid leukemia presenting with myeloid sarcoma in an adolescent.

Blood Res 2020 Jun;55(2):112-115

Departments of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea.

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http://dx.doi.org/10.5045/br.2020.2019191DOI Listing

testing in a population of Korean patients with pernicious anemia.

Blood Res 2020 Mar 30;55(1):69. Epub 2020 Mar 30.

Division of Hematolog/Oncology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.

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http://dx.doi.org/10.5045/br.2020.55.1.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106112PMC

Response to the letter by Langabeer on "Retrospective screening for Philadelphia-negative myeloproliferative neoplasms in patients with cerebral infarctions as revealed using the revised 2016 World Health Organization diagnostic criteria".

Authors:
Ik-Chan Song

Blood Res 2020 Mar 30;55(1):68. Epub 2020 Mar 30.

Division of Hematology/Oncology, Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.

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http://dx.doi.org/10.5045/br.2020.55.1.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106110PMC

Molecular screening for an underlying myeloproliferative neoplasm in patients with stroke: who and how?

Blood Res 2020 Mar 30;55(1):67-68. Epub 2020 Mar 30.

Cancer Molecular Diagnostics, St. James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.5045/br.2020.55.1.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106119PMC

Daratumumab in dialysis-dependent multiple myeloma.

Blood Res 2020 Mar 30;55(1):65-67. Epub 2020 Mar 30.

Division of Hematology and Bone Marrow Transplant, Max Super-Specialty Hospital, New Delhi, India.

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http://dx.doi.org/10.5045/br.2020.55.1.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106121PMC

Clinical significance of myeloproliferative neoplasms with V617F mutations and major translocations: a literature review with case presentation.

Blood Res 2020 Mar 30;55(1):62-65. Epub 2020 Mar 30.

Department of Laboratory Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

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http://dx.doi.org/10.5045/br.2020.55.1.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106111PMC

Mantle cell lymphoma relapsed after autologous stem cell transplantation: a single-center experience.

Blood Res 2020 Mar 30;55(1):57-61. Epub 2020 Mar 30.

Department of Hospital and Specialty Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

Background: Autologous stem cell transplantation (autoSCT) can extend remission of mantle cell lymphoma (MCL), but the management of subsequent relapse is challenging.

Methods: We examined consecutive patients with MCL who underwent autoSCT at Veterans Affairs Puget Sound Health Care System between 2009 and 2017 (N=37).

Results: Ten patients experienced disease progression after autoSCT and were included in this analysis. Read More

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http://dx.doi.org/10.5045/br.2020.55.1.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106113PMC

HIV-negative plasmablastic lymphoma: report of 8 cases and a comprehensive review of 394 published cases.

Blood Res 2020 Mar 30;55(1):49-56. Epub 2020 Mar 30.

Department of Lymphoma and Hematology, Hunan Cancer Hospital, Changsha, China.

Background: Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma (PBL) is a rare entity of diffuse large B-cell lymphoma (DLBCL). The clinicopathological features of and optimal treatment for HIV-negative PBL remain largely unknown.

Methods: To gain insight into this distinct lymphoma, we summarized the clinicopathologic characteristics of 8 unpublished HIV-negative PBLs and performed a comprehensive review of 394 published cases. Read More

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http://dx.doi.org/10.5045/br.2020.55.1.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106118PMC

Thromboprophylaxis after bariatric surgery.

Blood Res 2020 Mar 30;55(1):44-48. Epub 2020 Mar 30.

Sultan Qaboos University, Sultan Qaboos University Hospital, Oman.

Background: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a known cause of morbidity and mortality after bariatric surgery. However, the data concerning appropriate thromboprophylaxis after bariatric surgery is uncertain. The objective of this study was to evaluate the efficacy and safety of extended duration thromboprophylaxis in post-bariatric surgery patients. Read More

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http://dx.doi.org/10.5045/br.2020.55.1.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106117PMC

Human platelet lysate efficiency, stability, and optimal heparin concentration required in culture of mammalian cells.

Blood Res 2020 Mar 30;55(1):35-43. Epub 2020 Mar 30.

National Organization for Research and Control of Biologicals, Giza, Egypt.

Background: Fetal bovine serum (FBS) has been used to support the growth and proliferation of mammalian cells for decades. Owing to several risk factors associated with FBS, several trials have been conducted to evaluate substitutes to FBS with the same efficiency and the lower risk issues.

Methods: In this study, human platelet lysate (HPL) derived from activated human platelets was evaluated as an alternative to FBS due to the associated risk factors. Read More

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http://dx.doi.org/10.5045/br.2020.55.1.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106120PMC

Similar transplant outcomes between haploidentical and unrelated donors after reduced-intensity conditioning with busulfan, fludarabine, and anti-thymocyte globulin in patients with acute leukemia or myelodysplastic syndrome.

Blood Res 2020 Mar 30;55(1):27-34. Epub 2020 Mar 30.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: Although T-cell-replete hematopoietic cell transplantation (HCT) from haploidentical donors (HIDs) using anti-thymocyte globulin (ATG) has shown promising outcomes, previous studies often adopted heterogenous graft sources and conditioning.

Methods: We retrospectively compared HCT outcomes from 62 HIDs, 36 partially-matched unrelated donors (PUDs), and 55 matched unrelated donors (MUDs) in patients with acute leukemia or myelodysplastic syndrome using the same graft source of peripheral blood and a reduced intensity conditioning of busulfan, fludarabine, and ATG.

Results: The estimates of 3-yr disease-free survival (DFS) and overall survival (OS) rates were not significantly different among the MUD, HID, and PUD groups, at 46%, "41%, and 36%" for the DFS rate (=0. Read More

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http://dx.doi.org/10.5045/br.2020.55.1.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106115PMC

Characteristics of mutations in acute myeloid leukemia.

Blood Res 2020 Mar 30;55(1):17-26. Epub 2020 Mar 30.

Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: mutations occur in approximately 20% of AML cases and are associated with changes in DNA methylation. plays an important role in the regulation of hematopoietic progenitor cells and mutation is associated with promoter methylation. We analyzed the characteristics of mutations including their clinical significance in AML and their influence on promoter methylation and expression. Read More

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http://dx.doi.org/10.5045/br.2020.55.1.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106122PMC

A general view of CD33 leukemic stem cells and CAR-T cells as interesting targets in acute myeloblatsic leukemia therapy.

Blood Res 2020 Mar 30;55(1):10-16. Epub 2020 Mar 30.

Division of Cell Biology, Biocenter, Medical University Innsbruck, Innsbruck, Austria.

Acute myeloblastic leukemia (AML) is the most frequent acute leukemia in adulthood with very poor overall survival rates. In the past few decades, significant progresses had led to the findings of new therapeutic approaches and the better understanding of the molecular complexity of this hematologic malignancy. Leukemic stem cells (LSCs) play a key role in the initiation, progression, regression, and drug resistance of different types of leukemia. Read More

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http://dx.doi.org/10.5045/br.2020.55.1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106116PMC

Bibliometric analysis of studies about acute myeloid leukemia conducted globally from 1999 to 2018.

Blood Res 2020 Mar 30;55(1):1-9. Epub 2020 Mar 30.

Department of Public Health, Graduate School, Korea University, Seoul, Korea.

A bibliometric study is performed to analyze publication patterns in a specific research area and to establish a landscape model that can be used to quantitatively weigh publications. This study aimed to investigate AML research networks and to conduct a trend-related keyword analysis. We analyzed 48,202 studies about AML published from 1999 to 2019 in the Web of Science Core Collection. Read More

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http://dx.doi.org/10.5045/br.2020.55.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106114PMC

Beta-2 microglobulin as a prognostic factor of primary central nervous system lymphoma.

Blood Res 2019 Dec 20;54(4):285-288. Epub 2019 Dec 20.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.5045/br.2019.54.4.285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942142PMC
December 2019

EBV reactivation mimicking a lymphoproliferative disorder associated with ruxolitinib therapy for myelofibrosis.

Blood Res 2019 Dec 20;54(4):282-284. Epub 2019 Dec 20.

Division of Leukemia, Princess Margaret Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.5045/br.2019.54.4.282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942146PMC
December 2019

Clinical significance of T cell receptor excision circle (TREC) quantitation after allogenic HSCT.

Blood Res 2019 Dec 20;54(4):274-281. Epub 2019 Dec 20.

Clinical Hematology Department, Head of BMT Unit, Alexandria Faculty of Medicine, Alexandria, Egypt.

Background: Hematopoietic stem cell transplantation (HSCT) is a well-established treatment modality for a variety of diseases. Immune reconstitution is an important event that determines outcomes. The immune recovery of T cells relies on peripheral expansion of mature graft cells, followed by differentiation of donor-derived hematopoietic stem cells. Read More

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http://dx.doi.org/10.5045/br.2019.54.4.274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942145PMC
December 2019

The increasing trend of blood donation in Iran.

Blood Res 2019 Dec 20;54(4):269-273. Epub 2019 Dec 20.

HIV/STI Surveillance Research Center, WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.

Background: This is the first study on the blood donation trend in Iran at a national level. We report different characteristics of blood donation such as demographic status, donor type, donation trend, and geographical distribution of blood donation in Iran between 2003 and 2017.

Methods: This study used data registered in the donor vigilance part of the Iranian Blood Transfusion Organization. Read More

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http://dx.doi.org/10.5045/br.2019.54.4.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942136PMC
December 2019

Evaluating the effect of donor anxiety levels and lifestyle characteristics on the activation of platelet concentrates.

Blood Res 2019 Dec 20;54(4):262-268. Epub 2019 Dec 20.

Department of Infectious Disease and Clinical Microbiology, Health Science University, Gulhane Training and Education Hospital, Ankara, Turkey.

Background: Smoking, alcohol use, performing regular physical exercise, dietary habits, and anxiety level may cause platelet activation. We aimed to evaluate the anxiety levels, smoking status, alcohol intake, and sportive habits of donors, and determine their impact on the quality of apheresis-platelets.

Methods: State and Transient Anxiety Inventory (STAI) was used to determine the level of donors' anxiety. Read More

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http://dx.doi.org/10.5045/br.2019.54.4.262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942143PMC
December 2019

Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells.

Blood Res 2019 Dec 20;54(4):253-261. Epub 2019 Dec 20.

Department of Laboratory Medicine and Mitochondrial Research Laboratory, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun, Korea.

Background: Fluoranthene (FR) is a common environmental pollutant that exists in a complex mixture with other polycyclic aromatic hydrocarbons (PAHs). We identified biomarkers for monitoring FR exposure and investigated the rescue effect of FR-induced cellular toxicity via aryl hydrocarbon receptor (AHR) antagonist activity in bone marrow derived mesenchymal stem cells (BM-MSCs).

Methods: Morphological changes, viability, and rescue effects of an AHR antagonist (CH223191) were examined in BM-MSCs after exposure to FR. Read More

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http://dx.doi.org/10.5045/br.2019.54.4.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942141PMC
December 2019

Clinical impacts of inflammatory markers and clinical factors in patients with relapsed or refractory diffuse large B-cell lymphoma.

Blood Res 2019 Dec 20;54(4):244-252. Epub 2019 Dec 20.

Department of Hematology, Dong-A University Hospital, Busan, Korea.

Background: Systemic inflammatory response can be associated with the prognosis of diffuse large B cell lymphoma (DLBCL). We investigated the systemic factors significantly related to clinical outcome in relapsed/refractory DLBCL.

Methods: In 242 patients with DLBCL, several factors, including inflammatory markers were analyzed. Read More

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http://dx.doi.org/10.5045/br.2019.54.4.244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942137PMC
December 2019

Do not jump to hasty conclusions: all gamma delta T-cells neoplasms are not aggressive!

Blood Res 2019 Dec 20;54(4):243. Epub 2019 Dec 20.

Laboratory of Haematology, University Cancer Institute of Toulouse, Toulouse, France.

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http://dx.doi.org/10.5045/br.2019.54.4.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942139PMC
December 2019

Recurred breast cancer presenting with autoimmune hemolytic anemia.

Authors:
Joowon Park

Blood Res 2019 Dec 20;54(4):242. Epub 2019 Dec 20.

Department of Laboratory Medicine, Dankook University Hospital, Cheonan, Korea.

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http://dx.doi.org/10.5045/br.2019.54.4.242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942140PMC
December 2019

Chronic lymphocytic leukemia with unusual cytoplasmic anomalies.

Authors:
Nicolas Athanase

Blood Res 2019 Dec 20;54(4):241. Epub 2019 Dec 20.

Laboratoire d'hématologie, Centre Hospitalier Agen-Nérac, Agen, France.

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http://dx.doi.org/10.5045/br.2019.54.4.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942138PMC
December 2019

HIV/AIDS-related lymphoma: perspective from a regional cancer center in India.

Blood Res 2019 Sep 25;54(3):181-188. Epub 2019 Sep 25.

Department of Pathology, Kidwai Cancer Institute, Bengaluru, India.

Background: India has the third largest population of people living with HIV/AIDS (PLHA). Lymphoma is the second most common malignancy among PLHA. However, data are lacking regarding HIV/AIDS-related lymphoma (ARL) in India. Read More

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http://dx.doi.org/10.5045/br.2019.54.3.181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779940PMC
September 2019

Bone marrow metastasis of small cell lung carcinoma with spontaneous tumor lysis syndrome without hepatic metastasis at diagnosis: first case report in Korea and review of literature.

Blood Res 2019 Sep 25;54(3):231-233. Epub 2019 Sep 25.

Departments of Hematology and Cellular Therapy, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.

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http://dx.doi.org/10.5045/br.2019.54.3.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779933PMC
September 2019

Clinical features and treatment outcomes of Hodgkin lymphoma: A retrospective review in a Malaysian tertiary hospital.

Blood Res 2019 Sep 25;54(3):210-217. Epub 2019 Sep 25.

Department of Haematology, Hospital Sultanah Aminah, Ministry of Health Malaysia, Johor Bahru, Malaysia.

Background: Classical Hodgkin lymphoma (cHL) is a clinicopathologically unique, aggressive lymphoma arising from germinal center B-cells and is one of the most curable hematological malignancies. This study aimed to determine the clinical course, treatment regimens, response rates, and survival data of patients diagnosed with cHL in a tertiary center.

Methods: A retrospective review was conducted to include patients with a diagnosis of cHL from 2013 to 2017. Read More

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http://dx.doi.org/10.5045/br.2019.54.3.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779942PMC
September 2019

Mesenchymal stem cells in acute myeloid leukemia: a focus on mechanisms involved and therapeutic concepts.

Blood Res 2019 Sep 25;54(3):165-174. Epub 2019 Sep 25.

Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Drug resistance in cancer, especially in leukemia, creates a dilemma in treatment planning. Consequently, studies related to the mechanisms underlying drug resistance, the molecular pathways involved in this phenomenon, and alternate therapies have attracted the attention of researchers. Among a variety of therapeutic modalities, mesenchymal stem cells (MSCs) are of special interest due to their potential clinical use. Read More

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http://dx.doi.org/10.5045/br.2019.54.3.165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779935PMC
September 2019

The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A.

Blood Res 2019 Sep 25;54(3):204-209. Epub 2019 Sep 25.

Department of Pediatrics, Eulji University School of Medicine, Daejeon, Korea.

Background: Risk factors for the development of inhibitors in previously untreated patients (PUPs) have been reported; this is not the case in previously treated patients (PTPs) owing to fewer studies. Risk factors may differ for the development of PTP versus PUP inhibitors. We aimed to identify risk factors for PTP inhibitor development. Read More

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http://dx.doi.org/10.5045/br.2019.54.3.204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779946PMC
September 2019

Subgroup analysis of a phase 2/3 study of rurioctocog alfa pegol in patients with severe hemophilia A: efficacy and safety in previously treated Korean patients.

Blood Res 2019 Sep 25;54(3):198-203. Epub 2019 Sep 25.

Baxalta US Inc., a Takeda Company, Cambridge, MA, USA.

Background: The efficacy and safety of extended half-life, full-length, pegylated recombinant factor VIII rurioctocog alfa pegol [BAX 855, ADYNOVATE (USA)/ADYNOVI (Europe); Baxalta US Inc., a Takeda company, Lexington, MA, USA] was investigated in previously treated Korean patients with severe hemophilia A (HA).

Methods: A post hoc data analysis from the international, multicenter, phase 2/3 PROLONG-ATE study of rurioctocog alfa pegol in patients with severe HA (NCT01736475) determined annualized bleeding rates (ABRs) and rates of adverse events (AEs) in Korean patients treated in this study. Read More

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http://dx.doi.org/10.5045/br.2019.54.3.198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779944PMC
September 2019

Successful treatment of non-IgM lymphoplasmacytic lymphoma by bortezomib-containing regimen: case reports and review of literature.

Blood Res 2019 Sep 25;54(3):236-240. Epub 2019 Sep 25.

Hematology Division, National Hospital Organization Disaster Medical Center, Tokyo, Japan.

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http://dx.doi.org/10.5045/br.2019.54.3.236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779941PMC
September 2019

Prognostic utility of ADAMTS13 activity for the atypical hemolytic uremic syndrome (aHUS) and comparison of complement serology between aHUS and thrombotic thrombocytopenic purpura.

Blood Res 2019 Sep 25;54(3):218-228. Epub 2019 Sep 25.

Western Australian Centre for Thrombosis and Haemostasis, Murdoch University, Perth, Australia.

Background: Atypical hemolytic uremic syndrome (aHUS) involves dysregulation of the complement system, but whether this also occurs in thrombotic thrombocytopenic purpura (TTP) remains unclear. Although these conditions are difficult to differentiate clinically, TTP can be distinguished by low (<10%) ADAMTS13 activity. The aim was to identify the differences in complement activation products between TTP and aHUS and investigate ADAMTS13 activity as a prognostic factor in aHUS. Read More

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http://dx.doi.org/10.5045/br.2019.54.3.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779945PMC
September 2019

Neutrophil-erythrocyte rosettes in direct antiglobulin test-negative autoimmune hemolytic anemia.

Blood Res 2019 Sep 25;54(3):164. Epub 2019 Sep 25.

Department of Laboratory Medicine, Chungbuk National University Hospital, Cheongju, Korea.

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http://dx.doi.org/10.5045/br.2019.54.3.164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779931PMC
September 2019