450 results match your criteria Blood research[Journal]


Coexistence of -positive chronic myeloid leukemia and -mutated myelofibrosis successfully treated with dasatinib and ruxolitinib.

Blood Res 2019 Mar 21;54(1):77-79. Epub 2019 Mar 21.

Department of Laboratory Medicine, Chung-Ang University, Seoul, Korea.

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http://dx.doi.org/10.5045/br.2019.54.1.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439304PMC

A case of immune thrombocytopenia associated with invasive thymoma successfully treated with eltrombopag.

Blood Res 2019 Mar 21;54(1):74-79. Epub 2019 Mar 21.

Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.

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http://dx.doi.org/10.5045/br.2019.54.1.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439297PMC
March 2019
1 Read

Biphenotypic acute leukemia or acute leukemia of ambiguous lineage in childhood: clinical characteristics and outcome.

Blood Res 2019 Mar 21;54(1):63-73. Epub 2019 Mar 21.

Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.

Background: Acute leukemia (AL), not clearly assigned to myeloid, B-lymphoid, or T-lymphoid lineage, is classified as either biphenotypic acute leukemia (BAL) based on the European Group for Immunological Classification of Leukemias (EGIL) or acute leukemia of ambiguous lineage (ALAL) encompassing acute undifferentiated leukemia (AUL) and mixed-phenotype acute leukemia (MPAL) based on the World Health Organization (WHO) criteria.

Methods: Medical records of children newly diagnosed with BAL or ALAL, based on the EGIL or the 2008/2016 WHO criteria, respectively, admitted at Chonnam National University Hospital in 2001-2017 were retrospectively reviewed.

Results: Twelve (3. Read More

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http://dx.doi.org/10.5045/br.2019.54.1.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439300PMC
March 2019
3 Reads

ABCB1 and BMI1 mRNA expression in patients with chronic myeloid leukemia: impact on imatinib efficacy.

Blood Res 2019 Mar 21;54(1):57-62. Epub 2019 Mar 21.

Chemical Pathology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.

Background: ATP-binding cassette transporters are important in the mechanism of multidrug resistance. ABCB1 displays a high affinity for imatinib. BMI1 is a polycomb group protein thought to be overexpressed in leukemic cells. Read More

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http://dx.doi.org/10.5045/br.2019.54.1.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439291PMC
March 2019
1 Read

Analysis of hematologic parameters of donors, patients, and granulocyte concentrates to predict successful granulocyte transfusion.

Blood Res 2019 Mar 21;54(1):52-56. Epub 2019 Mar 21.

Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Granulocyte transfusion (GTx) is performed as a supportive therapy in severe neutropenic patients caused by various conditions. The study aimed to analyze the hematologic parameters of donors, patients, and granulocyte concentrates to predict successful GTx.

Methods: This study was performed in 281 donors, with their granulocyte concentrates being collected through apheresis, and in 54 severe neutropenic patients who had various hematologic diseases. Read More

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http://dx.doi.org/10.5045/br.2019.54.1.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439292PMC

Outcome and prognostic factors of children with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib followed by allogeneic hematopoietic cell transplantation in first remission.

Blood Res 2019 Mar 21;54(1):45-51. Epub 2019 Mar 21.

Department of Pediatrics, The Catholic University of Korea, Seoul, Korea.

Background: Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is a subset of ALL with poor prognosis. Here, we analyzed the outcomes and prognostic factors of children with Ph+ ALL who received imatinib and chemotherapy followed by allogeneic hematopoietic cell transplantation (HCT) in first complete remission (CR).

Methods: Thirty-one Ph+ ALL patients (female 10) diagnosed from January 2005 to December 2016 were included in the study. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2019.54.
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http://dx.doi.org/10.5045/br.2019.54.1.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439289PMC
March 2019
5 Reads

Microcytosis in children and adolescents with the sickle cell trait in Basra, Iraq.

Blood Res 2019 Mar 21;54(1):38-44. Epub 2019 Mar 21.

Center for Hereditary Blood Diseases, Basrah Heath Directorate, Basrah, Iraq.

Background: Microcytic anemia, the most common form of anemia in children and adolescents, is a heterogeneous group of diseases that is acquired or inherited. We assessed the frequency and causes of microcytosis in children and adolescents with the sickle cell trait (SCT).

Methods: This descriptive study included 95 subjects (49 males and 46 females) with SCT who attended Basra Center for Hereditary Blood Diseases for evaluation. Read More

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http://dx.doi.org/10.5045/br.2019.54.1.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439302PMC
March 2019
1 Read

Biochemical effects and safety of Gum arabic () supplementation in patients with sickle cell anemia.

Blood Res 2019 Mar 21;54(1):31-37. Epub 2019 Mar 21.

Department of Physiology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Background: Sickle cell anemia (SCA) is a hereditary chronic hemolytic anemia with several clinical consequences. Intravascular sickling of red blood cells leads to multi-organ dysfunction. Moreover, several biochemical abnormalities have been associated with SCA. Read More

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http://dx.doi.org/10.5045/br.2019.54.1.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439290PMC
March 2019
2 Reads

Efficacy of parenteral glutamine supplementation in adult hematopoietic stem cell transplantation patients.

Blood Res 2019 Mar 21;54(1):23-30. Epub 2019 Mar 21.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: Hematopoietic stem cell transplantation (HSCT) patients need parenteral nutrition because of nausea, vomiting, and mucositis caused by conditioning regimens. The demand for glutamine increases during the HSCT period. We evaluated the effects of glutamine-containing parenteral nutrition on the clinical outcomes of HSCT patients. Read More

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http://dx.doi.org/10.5045/br.2019.54.1.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439295PMC
March 2019
1 Read

Recent progress in laboratory diagnosis of thalassemia and hemoglobinopathy: a study by the Korean Red Blood Cell Disorder Working Party of the Korean Society of Hematology.

Blood Res 2019 Mar 21;54(1):17-22. Epub 2019 Mar 21.

Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea.

Genetic hemoglobin disorders are caused by mutations and/or deletions in the α-globin or β-globin genes. Thalassemia is caused by quantitative defects and hemoglobinopathies by structural defect of hemoglobin. The incidence of thalassemia and hemoglobinopathy is increased in Korea with rapid influx of people from endemic areas. Read More

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http://dx.doi.org/10.5045/br.2019.54.1.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439293PMC
March 2019
3 Reads

Molecular perspective of iron uptake, related diseases, and treatments.

Blood Res 2019 Mar 21;54(1):10-16. Epub 2019 Mar 21.

Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Iron deficiency anemia and anemia of chronic disorders are the most common types of anemia. Disorders of iron metabolism lead to different clinical scenarios such as iron deficiency anemia, iron overload, iron overload with cataract and neurocognitive disorders. Regulation of iron in the body is a complex process and different regulatory proteins are involved in iron absorption and release from macrophages into hematopoietic tissues. Read More

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http://dx.doi.org/10.5045/br.2019.54.1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439303PMC
March 2019
3 Reads

Cord blood 2.0: state of the art and future directions in transplant medicine.

Authors:
John E Wagner

Blood Res 2019 Mar 21;54(1):7-9. Epub 2019 Mar 21.

Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.5045/br.2019.54.1.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439299PMC

Organ-specific considerations for marginal zone lymphomas in Korea, based on Consortium for Improving Survival of Lymphoma (CISL) and Korean clinical studies.

Blood Res 2019 Mar 21;54(1):4-6. Epub 2019 Mar 21.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.5045/br.2019.54.1.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439296PMC

Breast implant-associated anaplastic large cell lymphoma.

Blood Res 2019 Mar 21;54(1). Epub 2019 Mar 21.

Service d'Anatomie Pathologique, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.

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http://dx.doi.org/10.5045/br.2019.54.1.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439294PMC

Hemophagocytosis by blasts in acute lymphoblastic leukemia.

Blood Res 2019 Mar 21;54(1). Epub 2019 Mar 21.

Laboratoire d'Hématologie, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.

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http://dx.doi.org/10.5045/br.2019.54.1.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439298PMC
March 2019
1 Read

Recurrent bilateral deep vein thrombosis after cava vein resection in a patient with leiomyosarcoma.

Blood Res 2019 Mar 21;54(1). Epub 2019 Mar 21.

Venous Thromboembolism Unit, Internal Medicine Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

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http://dx.doi.org/10.5045/br.2019.54.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439301PMC
March 2019
2 Reads

Erratum: The incidence of venous thromboembolism is not lowin Korean patients with advanced pancreatic cancer.

Authors:

Blood Res 2018 Dec 17;53(4):335-336. Epub 2018 Dec 17.

[This corrects the article on p. 227 in vol. 53, PMID: 30310790. Read More

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http://dx.doi.org/10.5045/br.2018.53.4.335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300681PMC
December 2018

Altered expression of lncRNA in chronic lymphocytic leukemia patients, correlation with cytogenetic findings.

Blood Res 2018 Dec 17;53(4):320-324. Epub 2018 Dec 17.

Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran, Iran.

Background: Recent studies have devoted much attention to non-protein-coding transcripts in relation to a wide range of malignancies. , a long non-coding RNA, has been reported to be associated with cancer progression and prognosis. Thus, we here determined gene expression in chronic lymphocytic leukemia (CLL), a genetically heterogeneous disease, and explored its possible relationships with cytogenetic abnormalities. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2018.53.
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http://dx.doi.org/10.5045/br.2018.53.4.320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300670PMC
December 2018
4 Reads

Relationship between liver iron concentration determined by R2-MRI, serum ferritin, and liver enzymes in patients with thalassemia intermedia.

Blood Res 2018 Dec 17;53(4):314-319. Epub 2018 Dec 17.

Department of Endocrinology, Al-Elwiya Pediatric Teaching Hospital, Al-Rusafa Health Directorate, Baghdad, Iraq.

Background: Iron overload is a risk factor affecting all patients with thalassemia intermedia (TI). We aimed to determine whether there is a relationship of serum ferritin (SF) and alanine aminotransferase (ALT) with liver iron concentration (LIC) determined by R2 magnetic resonance imaging (R2-MRI), to estimate the most relevant degree of iron overload and best time to chelate in patients with TI.

Methods: In this cross-sectional study, 119 patients with TI (mean age years) were randomly selected and compared with 120 patients who had a diagnosis of thalassemia major (TM). Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2018.53.
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http://dx.doi.org/10.5045/br.2018.53.4.314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300676PMC
December 2018
5 Reads

Clinical presentation and treatment outcomes of primary ocular adnexal MALT lymphoma in Thailand.

Blood Res 2018 Dec 17;53(4):307-313. Epub 2018 Dec 17.

Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: Primary ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (POML) is the most common subtype of lymphoma involving the eyes in Thailand. We sought to assess the characteristics and treatment outcomes of patients with POML in Thailand.

Methods: We retrospectively reviewed patient data and included patients diagnosed with POML between January 2004 and December 2016 at Chiang Mai University Hospital and King Chulalongkorn Memorial Hospital, Thailand. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2018.53.
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http://dx.doi.org/10.5045/br.2018.53.4.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300677PMC
December 2018
11 Reads

Neutrophil oxidative burst as a diagnostic indicator of IgG-mediated anaphylaxis.

Blood Res 2018 Dec 17;53(4):299-306. Epub 2018 Dec 17.

Green Cross Reference Laboratory, Yongin, Korea.

Background: IgG-mediated anaphylaxis occurs after infusion of certain monoclonal antibody-based therapeutics. New tests are urgently needed to diagnose such reactions. We investigated whether allergens trigger neutrophil oxidative burst (OB) and if neutrophil OB occurs due to allergen-specific IgG (sIgG). Read More

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http://dx.doi.org/10.5045/br.2018.53.4.299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300672PMC
December 2018
3 Reads

Overexpression of indoleamine 2,3-dioxygenase correlates with regulatory T cell phenotype in acute myeloid leukemia patients with normal karyotype.

Blood Res 2018 Dec 17;53(4):294-298. Epub 2018 Dec 17.

Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Production of immunosuppressive enzymes such as indoleamine 2,3-dioxygenase (IDO) is one of the strategies employed by hematologic malignancies, including acute myeloid leukemia (AML), to circumvent immune surveillance. Moreover, IDO has the ability to convert CD4CD25 conventional T cells into regulatory T cells (Tregs). In this study, we evaluated the expression of IDO in cytogenetically normal acute myeloid leukemia (CN-AML) patients and its correlation with the Treg marker, FOXP3, as well as clinical and laboratory parameters. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2018.53.
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http://dx.doi.org/10.5045/br.2018.53.4.294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300669PMC
December 2018
10 Reads

Treatment and clinical outcomes of patients relapsing after allogeneic hematopoietic cell transplantation for myelodysplastic syndrome.

Blood Res 2018 Dec 17;53(4):288-293. Epub 2018 Dec 17.

Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Although allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment option for myelodysplastic syndrome (MDS), a substantial number of patients experience relapse. We reviewed the clinical outcomes of patients with MDS who relapsed after allogeneic HCT.

Methods: Thirty patients who experienced relapse or progression after allogeneic HCT for MDS between July 2000 and May 2016 were included in this retrospective analysis. Read More

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http://dx.doi.org/10.5045/br.2018.53.4.288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300680PMC
December 2018
8 Reads

Detection of bone marrow involvement with FDG PET/CT in patients with newly diagnosed lymphoma.

Blood Res 2018 Dec 17;53(4):281-287. Epub 2018 Dec 17.

Department of Hematology, Istanbul School of Medicine, Istanbul, Turkey.

Background: Bone marrow involvement (BMI) affects the lymphoma stage, survival, and treatment. Bone marrow biopsy (BMB) and fluorodeoxyglucose (FDG) positron emission tomography- computed tomography (PET/CT) are useful techniques to detect BMI. Both have advantages and disadvantages. Read More

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http://dx.doi.org/10.5045/br.2018.53.4.281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300678PMC
December 2018
14 Reads

Clinicohematological parameters and outcomes in a cohort of chronic lymphocytic leukemia patients with Deletion 17p from Pakistan.

Blood Res 2018 Dec 17;53(4):276-280. Epub 2018 Dec 17.

Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.

Background: Chronic lymphocytic leukemia (CLL) exhibits profound heterogeneity in its clinical course. Its clinicohematological and cytogenetic features play a significant role in determining the clinical course and in predicting the treatment response and prognosis. In this context, 17p deletion is known to predict a poor prognosis, as these cases are refractory to conventional therapy. Read More

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http://dx.doi.org/10.5045/br.2018.53.4.276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300684PMC
December 2018

Comparison of mean platelet volume levels in coronary artery ectasia and healthy people: systematic review and meta-analysis.

Blood Res 2018 Dec 17;53(4):269-275. Epub 2018 Dec 17.

Clinical Research Development Center, Imam Ali and Taleghani Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Coronary artery ectasia (CAE) is defined as the dilation of a segment of a coronary vessel to at least 1.5 times the diameter of its normal adjacent segment. Mean platelet volume (MPV) plays a role in acute coronary syndromes, with high MPV correlating to poor prognosis for acute thrombotic events and CAE. Read More

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http://dx.doi.org/10.5045/br.2018.53.4.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300668PMC
December 2018
1 Read

Small cell variant of T-cell prolymphocytic leukemia with atypical presentation.

Authors:
Joowon Park

Blood Res 2018 Dec 17;53(4):266. Epub 2018 Dec 17.

Department of Laboratory Medicine, Dankook University Hospital, Cheonan, Korea.

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http://dx.doi.org/10.5045/br.2018.53.4.266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300671PMC
December 2018

Cytoplasmic azurophilic inclusion bodies in reactive plasmacytosis.

Blood Res 2018 Dec 17;53(4):265. Epub 2018 Dec 17.

Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.5045/br.2018.53.4.265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300679PMC
December 2018

Erratum: Evaluation of thrombocytopenia in the hematology clinic: a case series from a large tertiary care center.

Authors:

Blood Res 2018 Sep 28;53(3):264. Epub 2018 Sep 28.

[This corrects the article on p. 166 in vol. 53, PMID: 29963525. Read More

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http://dx.doi.org/10.5045/br.2018.53.3.264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170313PMC
September 2018

Philadelphia-positive mixed phenotype acute leukemia presenting with α fusion transcript without t(15;17) on cytogenetic studies.

Blood Res 2018 Sep 28;53(3):256-260. Epub 2018 Sep 28.

Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.

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http://dx.doi.org/10.5045/br.2018.53.3.256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170305PMC
September 2018
4 Reads

A misleading presentation of T cell/histiocyte rich B-cell lymphoma mimicking osteomyelitis.

Blood Res 2018 Sep 28;53(3):250-251. Epub 2018 Sep 28.

Department of Hematology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2018.53.
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http://dx.doi.org/10.5045/br.2018.53.3.250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170306PMC
September 2018
14 Reads

Spectrum of mitochondrial genome instability and implication of mitochondrial haplogroups in Korean patients with acute myeloid leukemia.

Blood Res 2018 Sep 28;53(3):240-249. Epub 2018 Sep 28.

Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea.

Background: Mitochondrial DNA (mtDNA) mutations may regulate the progression and chemosensitivity of leukemia. Few studies regarding mitochondrial aberrations and haplogroups in acute myeloid leukemia (AML) and their clinical impacts have been reported. Therefore, we focused on the mtDNA length heteroplasmies minisatellite instability (MSI), copy number alterations, and distribution of mitochondrial haplogroups in Korean patients with AML. Read More

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http://dx.doi.org/10.5045/br.2018.53.3.240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170299PMC
September 2018
16 Reads

A cross-sectional retrospective study to analyze the underlying causes and clinical characteristics of children with reactive thrombocytosis at a Korean tertiary medical center.

Blood Res 2018 Sep 28;53(3):233-239. Epub 2018 Sep 28.

Department of Pediatrics, Keimyung University School of Medicine and Dongsan Medical Center, Daegu, Korea.

Background: Reactive thrombocytosis (RT) is a common condition among children, although no studies have examined the etiology or clinical characteristics of RT among Korean children.

Methods: This retrospective study evaluated children with RT at a single Korean tertiary center during a 10-year period.

Results: RT accounted for 13. Read More

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http://dx.doi.org/10.5045/br.2018.53.3.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170300PMC
September 2018
7 Reads

The incidence of venous thromboembolism is not lowin Korean patients with advanced pancreatic cancer.

Blood Res 2018 Sep 28;53(3):227-232. Epub 2018 Sep 28.

Division of Hematology & Oncology, Department of Internal Medicine, Soonchunhyang University, College of Medicine, Seoul Hospital, Seoul, Korea.

Background: Pancreatic cancer is among the most common malignancies associated with venous thromboembolism (VTE). Asian patients are known to have a lower incidence of VTE compared to Caucasian patients. However, few studies have investigated the incidence of VTE in Asian patients with pancreatic cancer. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2018.53.
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http://dx.doi.org/10.5045/br.2018.53.3.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170311PMC
September 2018
14 Reads

Bendamustine, etoposide, and dexamethasone to mobilize peripheral blood hematopoietic stem cells for autologous transplantation in non-Hodgkin lymphoma.

Blood Res 2018 Sep 28;53(3):223-226. Epub 2018 Sep 28.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Bendamustine is a chemotherapeutic agent that has shown broad activity in patients with lymphoid malignancies. It contains both alkylating and nucleoside analog moieties, and thus, is not commonly used for stem cell mobilization due to concerns that it may adversely affect stem cell collection. Here we describe the lymphoma subset of a prospective, non-randomized phase II study of bendamustine, etoposide, and dexamethasone (BED) as a mobilization agent for lymphoid malignancies. Read More

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http://dx.doi.org/10.5045/br.2018.53.3.223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170297PMC
September 2018
7 Reads

Smudge cell percentage as a surrogate marker for ZAP-70 expression in patients with chronic lymphocytic leukemia.

Blood Res 2018 Sep 28;53(3):218-222. Epub 2018 Sep 28.

Department of Hematology, Medical Research Institute, University of Alexandria, Alexandria, Egypt.

Background: This study aimed to evaluate the prognostic value of smudge cell percentage as a surrogate marker for zeta-chain-associated protein kinase 70 (ZAP-70) expression in chronic lymphocytic leukemia (CLL) patients.

Methods: Sixty three newly diagnosed CLL patients were investigated at the Hematology Department of the Medical Research Institute of Alexandria University with complete blood count, lactate dehydrogenase, β microglobulin levels, ZAP-70 expression, and estimation of the percentage of smudge cells.

Results: The percentage of smudge cells ranged from 2 to 58% with a mean of 24. Read More

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http://dx.doi.org/10.5045/br.2018.53.3.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170303PMC
September 2018
4 Reads

Effectiveness of L-asparaginase-based regimens compared to anthracycline-based regimens in newly diagnosed extranodal NK/T-cell lymphoma, nasal type: a single Mexican center experience.

Blood Res 2018 Sep 28;53(3):210-217. Epub 2018 Sep 28.

Department of Hematology-Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México.

Background: Extranodal NK/T-cell lymphoma, nasal type (ENKTCL) has a high prevalence in Asia and Latin American countries, such as Mexico, where it encompasses 40% of all T-cell non-Hodgkin lymphomas. Historically, responses to anthracycline-based therapies have been disappointing. Since data about the effectiveness of L-asparaginase-based regimens in Mexico are limited, we compared both therapies in our center. Read More

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http://dx.doi.org/10.5045/br.2018.53.3.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170315PMC
September 2018
2 Reads

Syndecan-1 (sCD138) levels in chronic lymphocytic leukemia: clinical and hematological correlations.

Blood Res 2018 Sep 28;53(3):205-209. Epub 2018 Sep 28.

Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.

Background: Syndecan-1 (sCD138) has recently been suggested to predict the clinical course of early-stage chronic lymphocytic leukemia (CLL), but few studies have been reported. This study assessed the role of syndecan-1 in the prognosis of patients with CLL and its correlation with other prognostic markers.

Methods: This prospective study was performed in the hematology department of an Indian tertiary care center, over nineteen months (Jun. Read More

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http://dx.doi.org/10.5045/br.2018.53.3.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170314PMC
September 2018

The prognostic impact of lymphocyte subsets in newly diagnosed acute myeloid leukemia.

Blood Res 2018 Sep 28;53(3):198-204. Epub 2018 Sep 28.

Department of Laboratory Medicine, Chungnam National University Hospital, Daejeon, Korea.

Background: Tumor-infiltrating lymphocytes, which form a part of the host immune system, affect the development and progression of cancer. This study investigated whether subsets of lymphocytes reflecting host-tumor immunologic interactions are related to the prognosis of patients with acute myeloid leukemia (AML).

Methods: Lymphocyte subsets in the peripheral blood of 88 patients who were newly diagnosed with AML were analyzed by quantitative flow cytometry. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2018.53.
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http://dx.doi.org/10.5045/br.2018.53.3.198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170312PMC
September 2018
14 Reads

Clinical features and survival outcomes of patients with lymphoplasmacytic lymphoma, including non-IgM type, in Korea: a single-center experience.

Blood Res 2018 Sep 28;53(3):189-197. Epub 2018 Sep 28.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: The incidence of lymphoplasmacytic lymphoma (LPL) is lower in Asian than in Western populations. Few studies have described the clinical features and treatment outcomes of patients with LPL, including non-IgM LPL, in East Asia.

Methods: We retrospectively analyzed patients diagnosed with LPL at Asan Medical Center between January 2001 and March 2016. Read More

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http://dx.doi.org/10.5045/br.2018.53.3.189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170298PMC
September 2018

Pseudo-Chediak-Higashi granules in myeloid cells in therapy-related AML with .

Blood Res 2018 Sep 28;53(3):188. Epub 2018 Sep 28.

Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea.

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2018.53.
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http://dx.doi.org/10.5045/br.2018.53.3.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170310PMC
September 2018
8 Reads

Multifocal large aggregates of pseudo-Gaucher cells in chronic myeloid leukemia.

Blood Res 2018 Sep 28;53(3):187. Epub 2018 Sep 28.

Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2018.53.
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http://dx.doi.org/10.5045/br.2018.53.3.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170307PMC
September 2018
14 Reads