2,352 results match your criteria Blood purification[Journal]


Cytokine Blood Filtration Responses in COVID-19.

Blood Purif 2020 May 28:1-9. Epub 2020 May 28.

Department of Medical Equipment Technology, College of Applied Medical Science, Majmaah University, Majmaah, Saudi Arabia,

The real issue with the COVID-19 pandemic is that a rapidly increasing number of patients with life-threatening complications are admitted in hospitals and are not well-administered. Although a limited number of patients use the intensive care unit (ICU), they consume medical resources, safety equipment, and enormous equipment with little possibility of rapid recovery and ICU discharge. This work reviews effective methods of using filtration devices in treatment to reduce the level of various inflammatory mediators and discharge patients from the ICU faster. Read More

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http://dx.doi.org/10.1159/000508278DOI Listing

Extracorporeal Blood Purification and Organ Support in the Critically Ill Patient during COVID-19 Pandemic: Expert Review and Recommendation.

Blood Purif 2020 May 26:1-11. Epub 2020 May 26.

Department of Critical Care, King's College London, Guy's & St Thomas' Hospital, London, United Kingdom,

Critically ill COVID-19 patients are generally admitted to the ICU for respiratory insufficiency which can evolve into a multiple-organ dysfunction syndrome requiring extracorporeal organ support. Ongoing advances in technology and science and progress in information technology support the development of integrated multi-organ support platforms for personalized treatment according to the changing needs of the patient. Based on pathophysiological derangements observed in COVID-19 patients, a rationale emerges for sequential extracorporeal therapies designed to remove inflammatory mediators and support different organ systems. Read More

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http://dx.doi.org/10.1159/000508125DOI Listing
May 2020
1.920 Impact Factor

Efficacy and Safety of Regional Anticoagulation with 4% Trisodium Citrate Versus Heparin in Extended Hemodialysis among Critical Patients with Cancer and Acute Kidney Injury.

Blood Purif 2020 May 8:1-7. Epub 2020 May 8.

Department of Nephrology, AC Camargo Cancer Center, Sao Paulo, Brazil,

Introduction: Patients with cancer admitted to critical care units are at increased risk of being affected with acute kidney injury (AKI) and mortality. Sustained low-efficiency dialysis (SLED) combines the cardiovascular stability of continuous therapy with the operational facility of conventional hemodialysis (HD). Citrate has become an alternative to heparin in anticoagulation because it favors the maintenance of filter patency and reduces bleeding. Read More

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http://dx.doi.org/10.1159/000507874DOI Listing

The Role of the Renin-Angiotensin System in Severe Acute Respiratory Syndrome-CoV-2 Infection.

Blood Purif 2020 Apr 28:1-5. Epub 2020 Apr 28.

Surgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy.

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http://dx.doi.org/10.1159/000507914DOI Listing

Early Leukapheresis Depletion in an Ex-Premature with Severe Acute Respiratory Distress Syndrome Due to Bordetella Pertussis and Coronavirus Infection.

Blood Purif 2020 Apr 27:1-3. Epub 2020 Apr 27.

Pediatric Intensive Care Unit, Emergency, Anaesthesia and Intensive Care Department, Bambino Gesù Children's Hospital, Rome, Italy.

We describe a 2 weeks corrected gestational age infant admitted in pediatric intensive care unit (PICU) for severe acute respiratory distress syndrome (ARDS) associated to Bordetella pertussis and Coronavirus infection. He developed leukocytosis as soon as ARDS required intubation and aggressive mechanical ventilation: hence he underwent 3 early therapeutic leukapheresis treatments in order to avoid the worsening of related cardiopulmonary complications, according to recent literature on pertussis infection in infants. The infant was discharged from PICU healthy. Read More

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http://dx.doi.org/10.1159/000507873DOI Listing

Coronavirus Disease 2019 in a Hemodialysis Patient.

Blood Purif 2020 Apr 27:1-4. Epub 2020 Apr 27.

Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.

There has been a global outbreak of the coronavirus disease 2019 (COVID-19) since December 2019. Here, we describe the case of a 49-year-old male undergoing maintenance hemodialysis (HD) who got infected with COVID-19 and our experience in performing HD for him. The patient's symptoms and lung imaging changes were atypical. Read More

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http://dx.doi.org/10.1159/000507877DOI Listing

Predictors of Hypophosphatemia and Outcomes during Continuous Renal Replacement Therapy.

Blood Purif 2020 Apr 22:1-8. Epub 2020 Apr 22.

Departments of Clinical Pharmacy and Translational Science and Medicine (Nephrology), University of Tennessee Health Science Center, Memphis, Tennessee, USA,

Introduction: Hypophosphatemia occurs in up to 80% of patients undergoing continuous renal replacement therapy (CRRT) and has been associated with poor outcomes. Whether preemptive phosphate supplementation is warranted in select patients has not been adequately explored. This single-center, retrospective cohort study evaluates predictors of hypophosphatemia and characterizes treatment approaches in adult patients undergoing at least 12 h of CRRT. Read More

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http://dx.doi.org/10.1159/000507421DOI Listing

Risk Factors for Community-Acquired Acute Kidney Injury in Medical Patients: A Nested Case-Control Study.

Blood Purif 2020 Apr 22:1-8. Epub 2020 Apr 22.

Department of Internal Medicine, Fundación Universitaria de Ciencias de la Salud, Hospital San José, Bogota, Colombia.

Introduction: Research about the risk factors associated with community-acquired acute kidney injury (CA-AKI) in acute medical diseases is scarce. Data extrapolation from surgical to medical illnesses is questionable.

Objectives: To evaluate potential risk factors and hospital outcomes associated with a CA-AKI in medical illnesses. Read More

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http://dx.doi.org/10.1159/000506502DOI Listing

Double Filtration Plasmapheresis in the Treatment of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis with Severe Kidney Dysfunction.

Blood Purif 2020 Apr 15:1-10. Epub 2020 Apr 15.

National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China.

Background: Therapeutic plasma exchange (TPE) has been recommended by guidelines for the treatment of anti-neutrophil cytoplasmic antibodies-associated vasculitis (AAV) with severe kidney dysfunction. In recent years, some researchers have proposed that double-filtration plasmapheresis (DFPP) can also be used effectively in the treatment of these patients, but the difference between the 2 modalities of plasmapheresis is not clear.

Methods: In this retrospective cohort study of AAV patients with serum creatinine ≥500 μmol/L from March 2013 to July 2018 who received TPE or DFPP treatment, we compared TPE and DFPP in terms of the changes of clinical parameters before and after plasmapheresis, the rates of adverse events during plasmapheresis, and kidney and patient survival during follow-up. Read More

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http://dx.doi.org/10.1159/000507615DOI Listing
April 2020
1.920 Impact Factor

Effect of Hemodialysis on Efficacy and Pharmacokinetics of Sofosbuvir Coformulated with Either Daclatasvir or Ledipasvir in Patients with End-Stage Renal Disease.

Blood Purif 2020 Apr 14:1-8. Epub 2020 Apr 14.

Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China,

Background/aims: Direct-acting antivirals (DAAs) play a key role in the eradication of hepatitis C virus (HCV) infection. However, limited data are available on DAA for treating HCV infection in hemodialysis (HD) patients. This study was to evaluate the pharmacokinetic characteristics and effectiveness of daclatasvir/sofosbuvir (DAC/SOF) and ledipasvir/SOF (LDV/SOF) in HD patients. Read More

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http://dx.doi.org/10.1159/000499161DOI Listing

Treatment of Uremic Tumoral Calcinosis in Maintenance Hemodialysis Patients.

Blood Purif 2020 Apr 14:1-7. Epub 2020 Apr 14.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China,

Background/aims: Uremic tumoral calcinosis (UTC) is a rare disease with metastatic tissue calcification in maintenance hemodialysis (HD) patients. However, limited data are available on the treatment of UTC in HD patients. This article mainly discusses the diagnostic findings and efficacy of treatment on HD patients with UTC. Read More

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http://dx.doi.org/10.1159/000506115DOI Listing

Coronavirus Disease 19 Pandemic and Extracorporeal Therapies in Intensive Care: "Bis Peccare in Bello Non Licet".

Blood Purif 2020 Apr 9:1-2. Epub 2020 Apr 9.

Department of Nephrology, Avicennes Military Hospital, Faculty of Medicine, Cadi Ayyad University, Marrakech, Morocco.

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http://dx.doi.org/10.1159/000507603DOI Listing

Impact of Consensus Papers versus Randomized Trials in Critical Care Nephrology.

Authors:
John A Kellum

Blood Purif 2020 Apr 8:1-5. Epub 2020 Apr 8.

Center for Critical Care Nephrology, CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA,

Introduction: Reports of consensus conferences are usually valued less than reports of clinical trials even when rigorous methodology is used. However, limited data are available comparing the impact of these 2 methods of shaping clinical practice.

Objective: Compare the publication impact of consensus conferences and clinical trials. Read More

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http://dx.doi.org/10.1159/000507422DOI Listing

Safeguarding the Maintenance Hemodialysis Patient Population during the Coronavirus Disease 19 Pandemic.

Blood Purif 2020 1;49(3):259-264. Epub 2020 Apr 1.

Department of Medicine, University of Padova, Padua, Italy,

The World Health Organization has recognized the pandemic nature of the coronavirus disease 19 (COVID-19) outbreak. A large proportion of positive patients require hospitalization, while 5-6% of them may need more aggressive therapies in intensive care. Most governments have recommended social separation and severe measures of prevention of further spreading of the epidemic. Read More

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http://dx.doi.org/10.1159/000507537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179526PMC

Use of Fluoride as a Marker Solute to Quantify the Current Effective Delivered Dose in Continuous Renal Replacement Therapy: An "in vitro" Study.

Blood Purif 2020 Mar 20:1-7. Epub 2020 Mar 20.

Department of Health Sciences, Section of Anesthesiology, Intensive Care and Pain Medicine, University of Florence, Florence, Italy.

Background: The current effective delivered dose is a quality indicator for continuous renal replacement therapy. Its periodic assessment might enable physicians to deliver personalised treatments. Yet, its quantification as by extracorporeal urea clearance (Cl) is cumbersome and thus often neglected in routine practice. Read More

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http://dx.doi.org/10.1159/000507013DOI Listing

Immunoadsorption Combined with Membrane Filtration to Counteract Early Treatment-Refractory Antibody-Mediated Rejection.

Blood Purif 2020 Mar 19:1-10. Epub 2020 Mar 19.

Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Vienna, Austria.

Introduction: Immunoadsorption (IA) represents a therapeutic option for acute antibody-mediated rejection (ABMR) after kidney transplantation. The addition of membrane filtration (MF) to enhance elimination of macromolecular components that potentially contribute to rejection, such as key complement component C1q and alloreactive IgM, may be an effective strategy to further improve its therapeutic efficiency.

Results: Here we present 4 consecutive patients with episodes of HLA donor-specific antibody-positive ABMR nonresponsive to cycles of 6-16 sessions of IA treatment. Read More

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http://dx.doi.org/10.1159/000506504DOI Listing

Anticoagulation Effect and Safety Observation of Regional Citrate Anticoagulation for Double-Filtration Plasmapheresis in Critical Patients.

Blood Purif 2020 Mar 19:1-8. Epub 2020 Mar 19.

Department of Critical Care Unit and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China,

Introduction: Double-filtration plasmapheresis (DFPP) is a semi-selective blood purification method based on dual filtration system. Regional citrate anticoagulation (RCA) is an appealing anticoagulation alternative in DFPP. However, there are still few reports on the safety of RCA in DFPP treatment. Read More

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http://dx.doi.org/10.1159/000505613DOI Listing

Relapsing and Progressive Complications of Severe Hypertriglyceridemia: Effective Long-Term Treatment with Double Filtration Plasmapheresis.

Blood Purif 2020 Mar 19:1-11. Epub 2020 Mar 19.

Department of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Background: Severe hypertriglyceridemia (HTG) is associated with major complications such as acute or relapsing pancreatitis (AP) and atherosclerotic cardiovascular disease (ASCVD). Rapid elimination of triglyceride (TG)-rich lipoproteins (LP) with double filtration plasmapheresis (DFPP) without need for substitution has been found to be effective for the acute, short-term treatment of HTG-induced AP. Data on the long-term use of DFPP to prevent HTG-associated complications are scarce. Read More

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http://dx.doi.org/10.1159/000506506DOI Listing
March 2020
1.920 Impact Factor

Coronavirus Epidemic and Extracorporeal Therapies in Intensive Care: si vis pacem para bellum.

Blood Purif 2020 13;49(3):255-258. Epub 2020 Mar 13.

International Renal Research Institute Vicenza, Vicenza, Italy.

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http://dx.doi.org/10.1159/000507039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179535PMC

Kidney Health for Everyone Everywhere - From Prevention to Detection and Equitable Access to Care.

Blood Purif 2020 Mar 11:1-8. Epub 2020 Mar 11.

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, California, USA.

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Read More

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http://dx.doi.org/10.1159/000506966DOI Listing
March 2020
1.920 Impact Factor

The Advantages of Using Vascular Dilators in Angioaccess Surgery.

Authors:
Branko Fila

Blood Purif 2020 Mar 6:1-5. Epub 2020 Mar 6.

Department of Vascular Surgery, University Hospital Dubrava, Zagreb, Croatia,

The creation of a functional angioaccess is the cornerstone in treatment of chronic hemodialysis patients. The aim of this article is to review the use of vascular probes as a simple and cheap tool that could help surgeons in preparation of vessels and with creation of an anastomosis. Autogenous arteriovenous fistula is the best angioaccess available but is hampered by its relatively high non-maturation rate. Read More

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http://dx.doi.org/10.1159/000506503DOI Listing

Peritoneal Dialysis as an Urgent-Start Option for Incident Patients on Chronic Renal Replacement Therapy: World Experience and Review of Literature.

Blood Purif 2020 Mar 6:1-6. Epub 2020 Mar 6.

Botucatu School of Medicine, UNESP, Botucatu, Brazil,

Chronic kidney disease is a significant problem of public health worldwide, and up to 60% of patients start dialysis in an unplanned manner without a definitive dialysis access. Recently, peritoneal dialysis (PD) has emerged as an alternative to unplanned chronic dialytic method, and the world collective experience shows that PD can be an efficient, safe, and cost-effective alternative with comparable outcomes to the planned PD and urgent-start hemodialysis (HD). More importantly, as compared to urgent-start HD using a central venous catheter, urgent-start PD has significantly fewer incidences of catheter-related bloodstream infections, dialysis-related mechanical complications, and need for dialysis catheter reinsertions during the initial time of the therapy. Read More

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http://dx.doi.org/10.1159/000506505DOI Listing

Complications of Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy: An Observational Study.

Blood Purif 2020 Mar 3:1-9. Epub 2020 Mar 3.

Adult Intensive Care Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland,

Introduction: Regional citrate anticoagulation (RCA) is the recommended anticoagulation modality for continuous renal replacement therapy (CRRT). RCA was associated with a low rate of complications in randomized controlled trials. However, little is known about the type and rate of complications in real life. Read More

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http://dx.doi.org/10.1159/000506253DOI Listing

A Promising Innovative Treatment for ST-Elevation Myocardial Infarction: The Use of C-Reactive Protein Selective Apheresis: Case Report.

Blood Purif 2020 Feb 28:1-5. Epub 2020 Feb 28.

"Dedinje" Cardiovascular Institute, Belgrade, Serbia.

Background: In patients with ST-elevation myocardial infarction (STEMI), C-reactive protein (CRP) levels are associated with larger infarct size, transmural extent, and poor function of left ventricle and independently predict 30-day mortality. CRP-apheresis following STEMI showed to be feasible, safe, and has significant beneficial effect both on myocardial infarction size and wall motion. To the best of our knowledge, this is only the second published clinical evaluation of the efficacy and safety of selective CRP-apheresis in the STEMI treatment using Spectra-Optia and Pentrasorb CRP-adsorber systems. Read More

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http://dx.doi.org/10.1159/000506176DOI Listing
February 2020

Successful Reduction of Creatine Kinase and Myoglobin Levels in Severe Rhabdomyolysis Using Extracorporeal Blood Purification (CytoSorb®).

Blood Purif 2020 Feb 28:1-5. Epub 2020 Feb 28.

Department of Intensive Care, Erasmus Medical Centre, University Medical Center, Rotterdam, The Netherlands.

Rhabdomyolysis, if severe, can lead to acute kidney injury (AKI). Myoglobin is an iron and oxygen-binding protein that is freely filtered by the glomerulus. Precipitation of myoglobin in the nephrons' distal parts is responsible for tubular damage with AKI as a consequence. Read More

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http://dx.doi.org/10.1159/000505899DOI Listing
February 2020

Circuit Survival during Continuous Venovenous Hemodialysis versus Continuous Venovenous Hemofiltration.

Blood Purif 2020 21;49(3):281-288. Epub 2020 Feb 21.

Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia,

Background: Continuous renal replacement therapy (CRRT) technique may affect circuit lifespan. A shorter circuit life may reduce CRRT efficacy and increase costs.

Methods: In a before-and-after study, we compared circuit median survival time during continuous venovenous hemofiltration (CVVH) versus continuous venovenous hemodialysis (-CVVHD). Read More

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http://dx.doi.org/10.1159/000504037DOI Listing
February 2020

Extracorporeal Therapies in the Treatment of Focal Segmental Glomerulosclerosis.

Blood Purif 2020 Feb 19:1-11. Epub 2020 Feb 19.

Akron Nephrology Associates at Cleveland Clinic Akron General, Akron, Ohio, USA.

Focal segmental glomerulosclerosis (FSGS) is one of the most frequent and severe glomerular kidney disease with frequent progression to end-stage renal disease and a high rate of recurrence in renal transplantations. Due to intolerance or resistance to the current immunomodulatory treatments, the management of FSGS is a therapeutic challenge. Over the last few years, development in extracorporeal therapies has shown potential beneficial outcomes in drug-resistant and recurrent FSGS patients. Read More

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http://dx.doi.org/10.1159/000506277DOI Listing
February 2020

Ectopic Calcification in Uremia: Where Do We Stand?

Blood Purif 2020 Feb 19:1-2. Epub 2020 Feb 19.

Department of Nephrology, Renal Research Laboratory, Dialysis and Renal Transplant, Fondazione Ca' Granda IRCCS, Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1159/000506178DOI Listing
February 2020

Elevated Neutrophil Gelatinase-Associated Lipocalin for the Assessment of Structural versus Functional Renal Damage among ST-Segment Elevation Myocardial Infarction Patients.

Blood Purif 2020 Feb 19:1-7. Epub 2020 Feb 19.

Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel,

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of renal tubular damage. We investigated the incidence and possible implications of elevated NGAL levels (suggesting renal damage) compared to both functional and damage markers (manifested as serum creatinine [sCr] elevation) and no NGAL/sCr change, among -ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).

Methods: We included 131 patients with STEMI treated with PCI. Read More

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http://dx.doi.org/10.1159/000506175DOI Listing
February 2020

Association of Body Composition and Intradialytic Hypotension in Hemodialysis Patients.

Blood Purif 2020 19;49(3):334-340. Epub 2020 Feb 19.

Department of Nephrology, Guizhou Provincial People's Hospital, Guiyang, China.

Background/aim: The relationship between body mass index (BMI) and intradialytic hypotension (IDH) has been inconsistently reported, but no further research has investigated the correlation between body composition and IDH so far. This study aimed to determine whether the lean tissue index (LTI), fat tissue index (FTI), or both derived from body composition monitoring (BCM) is associated with IDH defined as a nadir intradialytic systolic blood pressure of <90 mm Hg and ≥3 episodes hypotension per 10 hemodialysis (HD) treatments in patients undergoing prevalent HD.

Methods: The observational cohort study comprised 1,463 patients receiving thrice-weekly HD from 13 dialysis centers. Read More

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http://dx.doi.org/10.1159/000504245DOI Listing
February 2020

Coupled Plasma Filtration Adsorption for Treatment of Capillary Leak Syndrome Superimposed to Acute Generalized Exanthematous Pustolosis: A Case Report.

Blood Purif 2020 18;49(3):372-378. Epub 2020 Feb 18.

Nephrology and Dialysis Unit, Department of Internal Medicine, ASUITS, Trieste, Italy.

Coupled plasma filtration adsorption (CPFA) is an extracorporeal supportive therapy based on nonspecific adsorption of pro- and anti-inflammatory mediators combined with continuous renal replacement therapy. The main field of CPFA application is septic shock, and there are limited data about its efficacy in the treatment of other acute conditions characterized by a dysregulation in immune homeostasis. Capillary leak syndrome (CLS) defines a life-threatening condition sustained by hypercytokinemia and characterized by abrupt onset of increased capillary permeability leading to severe generalized edema and hypovolemic shock refractory to fluid administration. Read More

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http://dx.doi.org/10.1159/000503770DOI Listing
February 2020

Serum Alkaline Phosphatase Level Predicts Cardiac Valve Calcification in Maintenance Hemodialysis Patients.

Blood Purif 2020 Feb 12:1-10. Epub 2020 Feb 12.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.

Purpose: Cardiac valve calcification (CVC) is frequently occurred in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. This study aimed to evaluate the relationships between risk factors and extent of CVC and further provide the treatment target in MHD patients.

Methods: One hundred and forty-five patients who received MHD ≥3 months were enrolled. Read More

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http://dx.doi.org/10.1159/000505846DOI Listing
February 2020

Chronic Therapy with Sucroferric Oxyhydroxide Does Not Affect Iron and Anemia Markers in Dialysis Patients.

Blood Purif 2020 Feb 12:1-8. Epub 2020 Feb 12.

Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.

Introduction: Sucroferric oxyhydroxide (SOH) is an iron-based phosphate binder (PB), and its use has been widely expanded since its initial approval in 2014. Based on the existing data, however, it remains yet unclear whether its long-term administration is followed by iron overload in dialysis patients. The purpose of this observational study was to evaluate the longstanding effects of SOH on the anemia and iron indices in patients on dialysis. Read More

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http://dx.doi.org/10.1159/000505432DOI Listing
February 2020

Brief Report: A Case of Tramadol Overdose: Extracorporeal Life Support and Hemoperfusion as Life-Saving Treatment.

Blood Purif 2020 Feb 4:1-4. Epub 2020 Feb 4.

Department of Anaesthesia and Intensive Care Unit, I.R.C.C.S. San Matteo Hospital and University of Pavia, Pavia, Italy.

We describe the case of a 49-year-old woman with a Tramadol intoxication associated with multiorgan failure. Veno-arterial femoro-femoral extracorporeal life support (VA-ECLS) and hemoperfusion (HP) were used as rescue treatments. The emergency medical service found a woman at home unconscious. Read More

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http://dx.doi.org/10.1159/000505845DOI Listing
February 2020

Successful Treatment of Allopurinol-Induced Severe Skin Reactions with Double Filtration Plasmapheresis: A Case Report.

Blood Purif 2020 Feb 4:1-5. Epub 2020 Feb 4.

Department of Nephrology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China,

Severe cutaneous adverse reactions (SCAR) are uncommon and acute and frequently represent a drug reaction. For years, allopurinol use has remained the highest risk factor for SCARs worldwide. There are multiple risk factors for allopurinol-induced SCARs, including genetic and non-genetic factors. Read More

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http://dx.doi.org/10.1159/000506040DOI Listing
February 2020
1.920 Impact Factor

Citrate-Based Self-Circulation Anticoagulation Protocol for Discontinuity of Continuous Renal Replacement Therapy.

Blood Purif 2020 Feb 4:1-6. Epub 2020 Feb 4.

Intensive Care Unit, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Children Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.

Background/aims: Continuous renal replacement therapy (CRRT) has been used widely in the treatment of critically ill children for its continuity. However, sometimes we have to interrupt the continuity for necessary surgeries or blood transfusions. Our objective was to demonstrate a feasible self-circulation anticoagulation protocol based on citrate (CSAP) to address discontinuity during CRRT. Read More

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http://dx.doi.org/10.1159/000504562DOI Listing
February 2020
1.920 Impact Factor

In vitro Evaluation of Linezolid and Doripenem Clearance with Different Hemofilters.

Blood Purif 2020 29;49(3):295-301. Epub 2020 Jan 29.

Department of Anesthesiology and Clinical Care Medicine, Fujita Health University School of Medicine, Toyoake, Japan.

Introduction: Renal replacement therapy (RRT) is widely used in the treatment of septic acute kidney injury. However, little is known about how the adsorption properties of hemofilters used in RRT affect antibiotic concentration. Because a cytokine-adsorption membrane is frequently used in RRT, it is important to determine the antibiotic adsorption capacity of this membrane. Read More

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http://dx.doi.org/10.1159/000504039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212696PMC
January 2020

Efficacy of HA330 Hemoperfusion Adsorbent in Patients Followed in the Intensive Care Unit for Septic Shock and Acute Kidney Injury and Treated with Continuous Venovenous Hemodiafiltration as Renal Replacement Therapy.

Blood Purif 2020 Jan 28:1-9. Epub 2020 Jan 28.

Health Sciences University Diyarbakır Gazi Yaşargil Education and Research Hospital Anesthesia and Reanimation Clinic, Diyarbakır, Turkey,

Introduction: Blood purification is an option for treatment of the source of sepsis when correcting patients' septic shock-induced clinical status. We investigated the efficacy of HA330 hemoperfusion adsorbent application with renal replacement therapy in patients with septic shock and acute kidney injury.

Methods: This prospective observational study involved 23 patients diagnosed with sepsis who underwent continuous venovenous hemodiafiltration and HA330 hemoperfusion for 2 h once daily for 3 days. Read More

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http://dx.doi.org/10.1159/000505565DOI Listing
January 2020

Feasibility of Online Haemodiafiltration in Sleep Apnoea: A Randomized Crossover Study.

Blood Purif 2020 Jan 24:1-10. Epub 2020 Jan 24.

Department of Nephrology, Medical and Interventional Services, John Hunter Hospital, Hunter New England Local Health District, Charlestown, New South Wales, Australia.

Background: Sleep apnoea is prevalent in dialysis patients. Previous studies identified excessive inflammation in -patients with sleep apnoea. Online haemodiafiltration -(OL-HDF) may reduce systematic inflammation through better clearance of middle molecules. Read More

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http://dx.doi.org/10.1159/000505572DOI Listing
January 2020

The Predictive Value of NT-Pro-Brain Natriuretic Peptide for Risk of Pneumonia in Patients on Maintenance Hemodialysis.

Blood Purif 2020 24;49(3):348-355. Epub 2020 Jan 24.

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.

Background/aims: Pneumonia is a common type of infection in maintenance hemodialysis (MHD) patients, while the treatment and prevention progress still keep limited. N-terminal-pro-brain natriuretic peptide (NT-proBNP) is an important marker in reflecting cardiac failure which also is a risk factor for pneumonia. This study aimed to determine the possible predictive value of NT-proBNP for pneumonia in MHD patients. Read More

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http://dx.doi.org/10.1159/000504524DOI Listing
January 2020

The miR-29b/Matrix Metalloproteinase 2 Axis Regulates Transdifferentiation and Calcification of Vascular Smooth Muscle Cells in a Calcified Environment.

Blood Purif 2020 Jan 24:1-11. Epub 2020 Jan 24.

Department of Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China,

Background: Vascular calcification (VC) is a common pathological lesion that promotes progress and mortality in cardiovascular disease. Vascular smooth muscle cells (VSMCs) acquiring an osteogenic phenotype facilitate VC occurrence and development. We recently reported that miR-29b-3p directly regulates the expression of matrix metalloproteinase 2 (MMP2). Read More

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http://dx.doi.org/10.1159/000505571DOI Listing
January 2020

Higher Postdialysis Lactic Acid Is Associated with Postdialysis Fatigue in Maintenance of Hemodialysis Patients.

Blood Purif 2020 Jan 22:1-7. Epub 2020 Jan 22.

Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Background: Postdialysis fatigue (PDF) is not an unusual symptom among hemodialysis (HD) patients; however, its causes remain unclear. The aim of this study was to analyze the factors responsible for PDF in maintenance HD patients.

Methods: This was a single-center cross-sectional study conducted between March 2018 and March 2019 at the Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University. Read More

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http://dx.doi.org/10.1159/000505612DOI Listing
January 2020

A tRial Evaluating Mid Cut-Off Value Membrane Clearance of Albumin and Light Chains in HemoDialysis Patients: A Safety Device Study.

Blood Purif 2020 Jan 22:1-11. Epub 2020 Jan 22.

Australasian Kidney Trials Network, The University of Queensland, Brisbane, Queensland, Australia.

Background: A new class of dialysis membrane, the mid cut-off (MCO) dialyzer, has been developed to improve the clearance of uremic toxins in hemodialysis (HD). The a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HemoDialysis patients (REMOVAL-HD) study aimed to determine if regular use of MCO dialyzer was safe and specifically did not result in a significant loss of albumin.

Methods: This investigator initiated, crossover, longitudinal, device study was conducted across 9 centers in Australia and New Zealand (n = 89). Read More

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http://dx.doi.org/10.1159/000505567DOI Listing
January 2020

Effect of L-Carnitine on Amino Acid Metabolism in Elderly Patients Undergoing Regular Hemodialysis.

Blood Purif 2020 Jan 22:1-8. Epub 2020 Jan 22.

Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Introduction: Among patients regularly undergoing hemodialysis, hypocarnitinaemia often develops as a consequence of inadequate dietary intake, reduced synthesis in the body, and considerable losses during hemodialysis.

Objectives: To evaluate the effects of L-carnitine supplementation on patients with end-stage kidney disease (ESKD) who underwent hemodialysis.

Methods: Thirty-one patients with ESKD, comprising 18 men and 13 women, with a median age of 72 (range 58-89) years, who underwent regular hemodialysis received treatment with L-carnitine for 1 year. Read More

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http://dx.doi.org/10.1159/000505609DOI Listing
January 2020

Correlation between the Incidence and Attributable Mortality Fraction of Acute Kidney Injury: A Systematic Review.

Blood Purif 2020 Jan 22:1-8. Epub 2020 Jan 22.

Department of Acute Medicine, The University of Tokyo Hospital, Tokyo, Japan,

Introduction: The incidence of acute kidney injury (AKI) as diagnosed by international standardized criteria as well as its mortality has undergone extreme variations. Although AKI is a significant worsening mortality factor, a higher prevalence may lead to better patient management, thereby lowering mortality. We investigated the correlation between AKI incidence and its associated mortality. Read More

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http://dx.doi.org/10.1159/000505568DOI Listing
January 2020

In vivo Elimination of Clonidine by Continuous Venovenous Hemofiltration in Critically Ill Patients.

Blood Purif 2020 Jan 21:1-5. Epub 2020 Jan 21.

Department of Clinical Pharmacy, Deventer Hospital, Deventer, The Netherlands.

Background: Clonidine is an α2-agonist that is commonly used for sedation in the intensive care unit. When patients are on continuous venovenous hemofiltration (CVVH) in the presence of kidney dysfunction, the sieving coefficient of clonidine is required to estimate how much drug is removed by CVVH. In the present study, we measured the sieving coefficient of clonidine in critically ill, ventilated patients receiving CVVH. Read More

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http://dx.doi.org/10.1159/000505610DOI Listing
January 2020

The Promising Role of Lung Ultrasound in Assessment of Volume Status for Patients Receiving Maintenance Renal Replacement Therapy.

Blood Purif 2020 Jan 15:1-4. Epub 2020 Jan 15.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1159/000505529DOI Listing
January 2020

Report of Dialysis-Induced Hypophosphatemia Leading to Reversible Encephalopathy Prevented by Adding Phosphorus to the Dialysate.

Blood Purif 2020 Jan 15:1-6. Epub 2020 Jan 15.

Division of Nephrology, Department of Medicine, Zuckerberg San Francisco General Hospital and University of California, San Francisco, California, USA,

Patients with advanced chronic kidney disease have an inability to excrete phosphorus normally leading to high serum concentrations of phosphorus. The hyperphosphatemia is even more pronounced in dialysis patients who often require large doses of phosphorus binders to combat the problem. Hemodialysis is able to remove fair amount of the extra phosphorus; however, the removal is often hampered by the fact that the phosphorus is removed only from the extracellular compartment and phosphorus is mainly intracellular. Read More

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http://dx.doi.org/10.1159/000504561DOI Listing
January 2020

Age Difference in the Association between Hyponatremia and Infection-Related Mortality in Peritoneal Dialysis Patients.

Blood Purif 2020 Jan 15:1-10. Epub 2020 Jan 15.

Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, NHC Key Laboratory of Nephrology, Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, China,

Objectives: This study aimed to examine the association of serum sodium with infection-related mortality and its age difference among continuous ambulatory peritoneal dialysis (CAPD) patients.

Methods: A total of 1,656 CAPD patients from January 2006 to December 2013 were included in this study. All patients were followed up until December 2018. Read More

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http://dx.doi.org/10.1159/000505614DOI Listing
January 2020

Clinical Effect of the Acrylonitrile-Co-Methallyl Sulfonate Surface-Treated Membrane as a Cytokine Adsorption Therapy for Sepsis due to Acute Panperitonitis: A Retrospective Cohort Study.

Blood Purif 2020 15;49(3):364-371. Epub 2020 Jan 15.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.

Introduction: Sepsis is a systemic inflammatory response syndrome caused by infectious diseases, with cytokines possibly having an important role in the disease mechanism. Acrylonitrile-co-methallyl sulfonate surface-treated (AN69ST) membrane is expected to improve the outcomes of patients with sepsis through cytokine adsorption.

Objective: This study aimed to investigate the clinical effect of the AN69ST membrane in comparison to standard continuous renal replacement therapy (CRRT) membranes for panperitonitis due to lower gastrointestinal perforation. Read More

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http://dx.doi.org/10.1159/000504560DOI Listing
January 2020