4,181,396 results match your criteria Blood purification[Journal]


Hypercortisolism in Newly Diagnosed Type 2 Diabetes: A Prospective Study of 384 Newly Diagnosed Patients.

Horm Metab Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Cross-sectional studies in small and selected populations report a high prevalence of hypercortisolism in patients with type 2 diabetes (T2D), which could have therapeutic implications, if confirmed. We therefore estimated the prevalence of hypercortisolism in a large and unselected cohort of recently diagnosed T2D patients. Consecutive patients with recently diagnosed T2D first underwent an overnight dexamethasone (1 mg) suppression test (OD). Read More

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December 2018
1 Read

Tracking Arteriovenous Fistula Maturation: A Novel Approach.

Blood Purif 2018 Dec 6:1-6. Epub 2018 Dec 6.

Renal Research Institute, New York, New York, USA.

Background: The time between the creation of an arteriovenous fistula (AVF) and its successful use is significantly longer in hemodialysis (HD) patients in the United States compared to those in other countries, and there is an urgent need to reduce the residence time of central-venous catheters (CVC).

Methods: Successful AVF creation and maturation results in typical hemodynamic changes, such as an increase in cardiac output and upper body blood flow (UBBF). In patients with CVC as vascular access, we measured once per minute intradialytic central-venous oxygen saturation (ScvO2) and hemoglobin levels simultaneously using the Crit-Line Monitor. Read More

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December 2018
4 Reads

Neurofilament Light in the Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium.

Dement Geriatr Cogn Disord 2018 Dec 6;46(5-6):346-357. Epub 2018 Dec 6.

Oslo Delirium Research Group, Department of Geriatric Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury.

Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults undergoing elective surgery. Read More

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December 2018
2 Reads

Impact of Hybrid Therapy Comprising Peritoneal Dialysis and Hemodialysis on Acute Cardiovascular Events.

Blood Purif 2018 Dec 6:1-7. Epub 2018 Dec 6.

Background: The impact of hybrid therapy comprising peritoneal dialysis (PD) and hemodialysis on cardiovascular events in PD patients remains unclear.

Objective: We aimed to evaluate the effect of hybrid therapy on cardiovascular events.

Methods: A total of 93 PD patients undergoing hybrid therapy for ≥3 years were divided into 2 groups according to left ventricular ejection fraction (LVEF): lower ejection fraction (LEF [n = 29], LVEF < 60%) and normal ejection fraction (NEF [n = 64], LVEF ≥60%). Read More

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December 2018
2 Reads

Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression.

Cell Physiol Biochem 2018 Dec 6;51(5):2123-2135. Epub 2018 Dec 6.

Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou,

Background/aims: Emerging evidence suggests a close link between gut microbiota and non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the association between gut microbiota and the DNA methylation of adiponectin (an adipocyte-specific adipocytokine) in rats, following diet-induced NAFLD.

Methods: 50 male SD rats were randomly divided into five groups with or without a high fat diet (HFD), antibiotics, and probiotics, in order to establish an imbalanced gut microbiota and probiotic treatment model in NAFLD rats. Read More

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December 2018
2 Reads

Gliquidone Alleviates Diabetic Nephropathy by Inhibiting Notch/Snail Signaling Pathway.

Cell Physiol Biochem 2018 Dec 6;51(5):2085-2097. Epub 2018 Dec 6.

Background/aims: Diabetic nephropathy is a common complication of diabetes. This study explored the renal protective effect and possible mechanism of gliquidone in mice with diabetic nephropathy.

Methods: Animal model of diabetic nephropathy was established in KKAy mice. Read More

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December 2018
3 Reads

Virtual Reality Simulation in Peritoneal Dialysis Training: The Beginning of a New Era.

Blood Purif 2018 Dec 6:1-5. Epub 2018 Dec 6.

Weltenmacher GmbH, VR Training-Application, Düsseldorf, Germany.

Background/aim: Peritonitis rates in peritoneal dialysis (PD) vary considerably not only across countries but also between centers in the same country. Patient education has been shown to significantly reduce infection rates but up till now training lacks standardization with patients being trained using different methods and media (e.g. Read More

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December 2018
3 Reads

Developing a Process for Returning Medically Actionable Genomic Variants to Latino Patients in a Federally Qualified Health Center.

Public Health Genomics 2018 Dec 6:1-8. Epub 2018 Dec 6.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

Aim: To develop a process for returning medically actionable genomic variants to Latino patients receiving care in a Federally Qualified Health Center.

Methods: Prior to recruitment, researchers met with primary care providers to (1) orient clinicians to the project, (2) establish a process for returning actionable and nonactionable results to participants and providers through the electronic health record, and (3) develop a process for offering clinical decision support for follow-up education and care. A Community Advisory Board was engaged to provide input on recruitment strategies and materials for conveying results to participants. Read More

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December 2018
3 Reads

Difficult Patient Behavior in Dialysis Facilities.

Blood Purif 2018 Dec 6:1-5. Epub 2018 Dec 6.

Difficult behavior exhibited by dialysis patients is a spectrum that includes nonadherence, verbal or physical abuse, and threatening acts. Such behaviors may lead to harmful consequences to the patient, other patients, the facility, and staff and can culminate in involuntary discharge. It is important to recognize that these "difficult behaviors" may be due to underlying psychosocial or medical issues, which places an onus on care providers to explore further. Read More

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December 2018
1 Read

Association of Central Venous Oxygen Saturation Variability and Mortality in Hemodialysis Patients.

Blood Purif 2018 Dec 6:1-8. Epub 2018 Dec 6.

Renal Research Institute, New York, New York,

Background: Central venous oxygen saturation (ScvO2) is correlated with cardiac output. In most patients, ScvO2 declines during hemodialysis (HD) due to factors such as reduced preload, myocardial stunning, and intermittent arrhythmias. Previous research has shown that low ScvO2 is associated with higher mortality in chronic HD patients. Read More

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December 2018
1 Read

Direct Effect of Septic Plasma in Human Cell Lines Viability.

Blood Purif 2018 Dec 6:1-7. Epub 2018 Dec 6.

Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.

Background: Sepsis is a life-threatening condition often associated with a high incidence of multiple organs injury. Several papers suggested the immune response by itself, with the production of humoral inflammatory mediators, is crucial in determining organ injury. However, little is known of how sepsis directly induces organ injury at the cellular levels. Read More

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December 2018
1 Read

High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome.

Cell Physiol Biochem 2018 Dec 6;51(5):2041-2051. Epub 2018 Dec 6.

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University and Chongqing Clinical Research Center for Geriatrics, Chongqing,

Background/aims: Alarin has been reported to be related with increased food intake and body weight. The relationship of circulating Alarin with insulin resistance or metabolic syndrome (MetS), however, is unknown. This study aimed to investigate the physiological role of Alarin and its association with MetS in humans. Read More

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December 2018
1 Read

Longer schooling but not better off? A quasi-experimental study of the effect of compulsory schooling on biomarkers in France.

Soc Sci Med 2018 Nov 23;220:379-386. Epub 2018 Nov 23.

Department of Social and Behavioral Sciences, Harvard T H Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA; CUNY Graduate School of Public Health and Health Policy, 205 East 42nd Street, New York, NY, 10017, USA.

Less schooling is associated with increased biological risks for chronic disease, but whether increasing years of schooling through policy interventions reduces these risks remains unclear. We examine the effect of a major education reform introduced in 1959 that raised the minimum school leaving age from 14 to 16 years in France, offering a unique natural experiment. We assess the causal impact of increased schooling duration on 16 biomarkers of cardiovascular, metabolic, organ and immune function in a large cohort of men and women born around 1953. Read More

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November 2018
5 Reads

Intraventricular blood flow with a fully dynamic mitral valve model.

Comput Biol Med 2018 Nov 29;104:197-204. Epub 2018 Nov 29.

Department of Chemical Engineering, Faculty of Applied Science, Delft University of Technology, the Netherlands.

Mitral valve (MV) leaflets affect the formation, growth, and decay of vortices in the left ventricle (LV) during diastolic filling. The shape and motion of MV leaflets are simplified in most studies due to computational restrictions. In this study, we present a newly developed mathematical method to model the dynamic movement of valve leaflets and annulus, which is based on in vivo data obtained with magnetic resonance imaging (MRI). Read More

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November 2018
2 Reads

A sensitive biosensing method for detecting of ultra-trace amounts of AFB1 based on "Aptamer/reduced graphene oxide" nano-bio interaction.

Colloids Surf B Biointerfaces 2018 Dec 1;175:98-105. Epub 2018 Dec 1.

Department of Chemistry, Payame Noor University (PNU), P.O. Box: 19395-4697, Tehran, Iran. Electronic address:

A simple, low-cost and sensitive label-free aptasensor assembled with assisting reduced graphene oxide nanosheets as the signal amplifier was fabricated and applied for detecting ultra-low levels of Aflatoxin B1(AFB1) through a nano-bio interaction system. The conditions of different modified glassy carbon electrodes as the base of aptasensor were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The performance of the fabricated aptasensor was evaluated by FESEM, HRTEM and AFM images. Read More

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December 2018

Temporal dynamics of cortisol-associated changes in mRNA expression of glucocorticoid responsive genes FKBP5, GILZ, SDPR, PER1, PER2 and PER3 in healthy humans.

Psychoneuroendocrinology 2018 Nov 30;102:63-67. Epub 2018 Nov 30.

Department of Neurobehavioral Genetics, Institute of Psychobiology, University of Trier, D-54290, Trier, Germany. Electronic address:

Secretion of the stress hormone cortisol follows a circadian rhythm and is stimulated following stress exposure. Cortisol regulates the transcription of several genes, primarily through activation of the glucocorticoid receptor (GR). Previously, we showed an upregulation of PERIOD genes PER1 and PER3 after pharmacological/glucocorticoid challenge in vivo and in vitro. Read More

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November 2018
1 Read

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

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December 2018
2 Reads

Pulmonary impairment following respiratory viral infections is associated with high mortality in allogeneic hematopoietic cell transplant recipients.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Introduction: Pulmonary impairment predicts increased mortality in many settings, and respiratory viral infection (RVI) causes considerable morbidity and mortality in allogeneic hematopoietic cell transplant recipients (allo-HCT). We hypothesized that pulmonary impairment following respiratory viral infection, defined as a decline of forced expiratory volume in 1 second values by ≥10%, may identify allo-HCT recipients at high risk for mortality.

Methods: We studied all allo-HCT recipients at our institution who had RVI with respiratory syncytial virus, parainfluenza virus, or influenza from 2004-2013 and had pre-RVI and post-RVI pulmonary function tests. Read More

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December 2018

TroCCL4, a CC chemokine of Trachinotus ovatus, is involved in the antimicrobial immune response.

Fish Shellfish Immunol 2018 Dec 3. Epub 2018 Dec 3.

State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, PR China.

CC chemokines are a large subfamily of chemokines that play an important role in the innate immune system. To date, several CC chemokines have been identified in fish species; however, the activities and functions of these putative chemokines remain ambiguous in teleosts, especially in the golden pompano, Trachinotus ovatus. Here, we characterized CC chemokine ligand 4 from T. Read More

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December 2018
2 Reads

Posterior Extensive Circumferential Decompressive Reconstructive Technique in surgical treatment of Upper Thoracic Spine Compressive Lesions.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopedic Surgery and Traumatology and Minia University Hospital, Mohammed Badway str., 61111, El-Minia, Egypt; Minia University Spine Unit (MUSU), Faculty of Medicine, Minia University. Minia University Hospital, Mohammed Badway str., 61111, El-Minia, Egypt. Electronic address:

Background Data: Complexity in ventral surgical exposure, presence of scapula and large para-scapular musculature during posterior surgery are the main obstacles in operative treatment of Upper Thoracic Spine Compressive Lesions (UTSCL) like trauma, tuberculosis and neoplasm. Recently, the advantages of combined ventro-dorsal surgery could be successfully gained using 1-stage posterior salvage technique with enough accessibility to all three spinal columns.

Purpose: Retrospective evaluation of 35 patients with UTSCL treated by Posterior Extensive Circumferential Decompressive Reconstructive (PECDR) procedure. Read More

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December 2018
1 Read

Prediction of neutrophil-to-lymphocyte ratio in the diagnosis and progression of autoimmune encephalitis.

Neurosci Lett 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University, Jing Wu Road, Huaiyin District, Jinan, 250021, Shandong, China. Electronic address:

Objective: Autoimmune encephalitis (AIE) is a group of inflammatory disorders of the brain. The severity of AIE vary among individuals and it is always a challenge to predict. In this study, we measured the neutrophil-to-lymphocyte ratio (NLR), a novel potential biomarker of inflammatory status in other inflammatory diseases, in AIE patients and evaluated NLR as a biomarker for monitoring AIE progression. Read More

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December 2018
2 Reads

Loss of K607 and E877 interaction is a key reason for JAK2 K607N mutation caused acute myeloid leukemia.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. Electronic address:

Oncogenic activation of tyrosine kinase signaling pathway is recurrent in human leukemia. The acquired Janus kinase 2 (JAK2) K607N somatic mutation was detected in about 6.8% of acute myeloid leukemia (AML) patients. Read More

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December 2018
2 Reads
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Exploring potential new galactomannan source of Retama reatam seeds for food, cosmetic and pharmaceuticals: Characterization and physical, emulsifying and antidiabetic properties.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Industrial Engineering, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, SA, Italy.

In this study, physicochemical, interfacial and emulsifying properties of Retama reatam and guar galactomannans were comparatively investigated. The results showed that Retama reatam galactomannan is mainly composed of total carbohydrates (95.52%) and lower protein contents (0. Read More

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December 2018

Polyethylene glycol-decorated doxorubicin/carboxymethyl chitosan/gold nanocomplex for reducing drug efflux in cancer cells and extending circulation in blood stream.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea. Electronic address:

Polyethylene glycol (PEG)-decorated doxorubicin (Dox)/carboxymethyl chitosan (CMC)/gold nanoparticles (AuNPs) have been developed for cancer therapy. CMC was used as a reducing and stabilizing agent for the fabrication of AuNPs and Dox was loaded onto AuNPs as a chemotherapeutic agent. Dox-loaded CMC-stabilized AuNPs (Dox/CMC-AuNPs) with a mean diameter of 104. Read More

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December 2018
4 Reads

Mulberry leaf polysaccharides suppress renal fibrosis.

Authors:
Shengjun Wu

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Jiangsu Key Laboratory of Marine Bioresources and Environment, Huaihai Institute of Technology, 59 Cangwu Road, Haizhou 222005, China; Co-Innovation Center of Jiangsu Marine Bio-industry Technology, 59 Cangwu Road, Haizhou 222005, China; Jiangsu Key Laboratory of Marine Biotechnology, 59 Cangwu Road, Haizhou 222005, China. Electronic address:

A mulberry leaf polysaccharide (MLP-1) was prepared and partially characterised, and its anti-renal-fibrosis effects were investigated in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats. MLP-1, with a molecular weight of 2,792,624 Da, consisted of arabinose, glucose, xylose, rhamnose, and mannose in a molar ratio of 1:1.13:2. Read More

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December 2018
1 Read

The polyphenolic-polysaccharide complex of Agrimonia eupatoria L. as an indirect thrombin inhibitor - isolation and chemical characterization.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Organic and Pharmaceutical Technology, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 29, 50-370 Wrocław, Poland; Regional Specialist Hospital in Wrocław, Research and Development Centre, Kamieńskiego 73a, 51-124 Wrocław, Poland.

The polyphenolic-polysaccharide complex was isolated from the dried aerial parts of the medicinal plant Agrimonia eupatoria L. using a multi-step process involving the degreasing of the plant material by extraction with organic solvents, followed by extraction with hot alkali, neutralization, further separation with organic solvents and dialysis. The complex was homogeneous with a molecular weight of about 55 × 10 g/mol and consisted mainly of carbohydrates and polyphenols matrix, composed of lignin-related units, with the dominance of dimethoxyphenyl structures. Read More

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December 2018
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Chitosan-graft-poly(N-hydroxy ethyl acrylamide) copolymers: Synthesis, characterization and preliminary blood compatibility in vitro.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Biomedical Engineering, Near East University, Nicosia, P. O. Box: 99138, North Cyprus via Mersin 10, Turkey; Tissue Engineering and Biomaterials Research Centre, Near East University, P. O. Box: 99138, North Cyprus via Mersin 10, Turkey.

Poly(N-hydroxy ethyl acrylamide) was grafted onto chitosan in aqueous acidic medium using potassium per sulphate initiator to obtain polymer surfaces with blood compatibility for potential biomedical applications. Thermally cross-linked products were obtained upon drying at 60 °C overnight. Chemically cross-linked films were prepared using methylene bis acrylamide (MBA) cross-linker. Read More

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December 2018

Combined synergetic potential of metformin loaded pectin-chitosan biohybrids nanoparticle for NIDDM.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutics, GITAM University, Rushikonda, Visakapatnam 530045, Andhra Pradesh, India.

Rationale: Combined therapy is a promising approach over its preference to minimize the dose, adverse effects and enhanced therapeutic efficiency in a various diseases including diabetes.

Aim: The present research work is to explore combined synergistic anti-diabetic potential of chitosan and pectin with Metformin (CPM) nano-formulation, with special emphasis on effect of Metformin when integrated with bio polymers.

Methods: The biohybrid nanoparticles (CPMNP) were formulated by ionic gelation process. Read More

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December 2018
1 Read

Oxidation of cystatin imparted by riboflavin generated free radicals: Spectral analysis.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of life sciences, Aligarh Muslim University, Aligarh, UP 202002, India. Electronic address:

Thiol Protease inhibitors (cystatins) are endogenous natural inhibitors of cysteine proteases. They are present in all mammalians cells and body fluids. Cystatin are allocated into three major families. Read More

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December 2018
3 Reads

Gene polymorphisms of angiotensin-converting enzyme and angiotensinogen and risk of idiopathic ischemic stroke.

Gene 2018 Dec 3. Epub 2018 Dec 3.

Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, H.G.R. No 1. Dr. "Carlos Mac Gregor Sánchez Navarro" Instituto Mexicano del Seguro Social, Gabriel Mancera No. 222, Colonia Del Valle, CP 03100 Ciudad de México, Mexico.

Objective: The renin-angiotensin system (RAS) is a hormonal signaling mechanism implicated in the atherosclerosis and regulation of blood pressure. Angiotensin-converting enzyme (ACE) a key enzyme in the RAS, plays important roles in vascular remodeling atherosclerosis, and ischemic stroke. The aim of this study was to examine the possible contribution of the I/D in the ACE gene, M235T and T174M in the angiotensinogen (AGT) gene polymorphisms with ischemic stroke in young Mexican population. Read More

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December 2018
1 Read

Soluble mannose receptor levels in blood correlate to disease severity in patients with community-acquired pneumonia.

Immunol Lett 2018 Dec 3. Epub 2018 Dec 3.

Department of R&D, Hycult Biotechnology, Uden, the Netherlands. Electronic address:

Purpose: Community-acquired pneumonia (CAP) is the most common form of pneumonia and is a leading infectious cause worldwide. Identification of patients that are at risk to develop severe disease has proven to be a major challenge. Soluble mannose receptor (sMR; sCD206) is a new serum marker for macrophage activation. Read More

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December 2018
3 Reads
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