2,204 results match your criteria Blood purification[Journal]


Routine Is the Worst Enemy of the Dialysis Patient.

Blood Purif 2019 Apr 18:1-2. Epub 2019 Apr 18.

Clinical Research Branch, Division of Nephrology, Miulli General Hospital, Acquaviva delle Fonti, Italy.

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http://dx.doi.org/10.1159/000498980DOI Listing

Augmented Adsorptive Blood Purification during Continuous Veno-Venous Haemodiafiltration in a Severe Septic, Acute Kidney Injury Patient: Use of oXiris®: A Single Centre Case Report.

Blood Purif 2019 12;47 Suppl 3:1-6. Epub 2019 Apr 12.

Department of Renal Medicine, Singapore General Hospital, Singhealth-Duke Academic Medical Centre, Singapore, Singapore.

The use of the oXiris® haemofilter during continuous veno-venous haemodiafiltration (CVVHDF) for acute kidney injury (AKI) and severe sepsis is not completely understood. Although this filter has in vitro adsorptive properties for blood-borne cytokines and other humoural mediators of sepsis, its clinical usefulness is uncertain. Given its inherent adsorptive limitation for septic mediators, we developed a CVVHDF protocol in which the oXiris haemofilter was electively changed every 12 h even though there was no clotting or adverse circuit pressures. Read More

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http://dx.doi.org/10.1159/000499633DOI Listing
April 2019
1 Read

Practice of Extracorporeal Therapies for Septic Acute Kidney Injury Patients in Intensive Care Units in Mainland China.

Blood Purif 2019 12;47 Suppl 3:1-6. Epub 2019 Apr 12.

Medical Affairs, Baxter Healthcare (Asia) Pte Ltd, Singapore, Singapore,

Background: Continuous renal replacement therapy (CRRT) and other extracorporeal therapies for acute kidney injury (AKI) and other organ dysfunction syndromes in critically ill patients are common in the intensive care unit (ICU). Many studies have focused on clinical practice for managing these conditions. However, there are few studies that describe the utilization of extracorporeal therapies, especially CRRT, in patients with sepsis-associated AKI. Read More

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http://dx.doi.org/10.1159/000499456DOI Listing

Sepsis Management with a Blood Purification Membrane: European Experience.

Blood Purif 2019 12;47 Suppl 3:1-9. Epub 2019 Apr 12.

Baxter, Baxter Deutschland GmbH, Unterschleissheim, Germany.

Background: Septic shock is a leading cause of acute kidney injury (AKI). Endotoxins and cytokine levels are associated with the occurrence and severity of AKI, and different blood purification devices are available to remove them from circulation. One such device, oXiris, is a hollow-fibre purification filter that clears both endotoxins and cytokines. Read More

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http://dx.doi.org/10.1159/000499355DOI Listing
April 2019
2 Reads

oXiris® Use in Septic Shock: Experience of Two French Centres.

Blood Purif 2019 12;47 Suppl 3:1-7. Epub 2019 Apr 12.

Anaesthesia and Critical Care Medicine Department, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.

Background: Sepsis is a dysregulated host response to an infection and can result in organ dysfunctions and death. Extracorporeal blood purification techniques aim to improve the prognosis of these patients by modulating the unbalanced immune response. This study reports our experience with the use of the oXiris® membrane for septic shock patients requiring continuous renal replacement therapy (CRRT). Read More

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http://dx.doi.org/10.1159/000499510DOI Listing
April 2019
1 Read

Analysis of Endotoxin Adsorption in Two Swedish Patients with Septic Shock.

Blood Purif 2019 12;47 Suppl 3:1-3. Epub 2019 Apr 12.

Perioperative and Intensive Care, Skåne University Hospital, Lund, Sweden.

Background: Lipopolysaccharide (endotoxin) from the outer Gram-negative bacterial wall can induce a harmful immunologic response, involving hemodynamic deprivation, and is one important motor driving the septic cascade. The positively charged poly-imine ethylene layer on the oXiris membrane is capable of adsorbing negatively charged endotoxin molecules and removing them from the blood compartment. Endotoxin is detrimental and should be removed from blood. Read More

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http://dx.doi.org/10.1159/000499546DOI Listing
April 2019
1 Read

Hemofilter with Adsorptive Capacities: Case Report Series.

Blood Purif 2019 12;47 Suppl 3:1-6. Epub 2019 Apr 12.

Medical Affairs, Baxter Healthcare (Asia) Pte Ltd, Singapore, Singapore.

Background: oXiris is a blood purification product that has been launched recently in China. In addition to renal function support and fluid management capabilities, it can also adsorb cytokines and endotoxins. This may complement standard treatment for septic acute kidney injury (AKI) patients to control the amplitude of systemic inflammatory response responsible for acute tissue and organ damage. Read More

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http://dx.doi.org/10.1159/000499357DOI Listing
April 2019
1.920 Impact Factor

Continuous Renal Replacement Therapy with the Adsorbing Filter oXiris in Septic Patients: A Case Series.

Blood Purif 2019 12;47 Suppl 3:1-5. Epub 2019 Apr 12.

Cardiac Surgery European Hospital Rome, Rome, Italy.

Background: Extracorporeal treatment may be useful during sepsis, but definitive recommendations are lacking. Aim of this study is to review retrospectively the medical records of septic patients submitted to continuous renal replacement therapy (CRRT) with the adsorbing membrane oXiris and evaluate (1) the safety of the device, (2) the cardiorenal response, and (3) the immunological response.

Materials And Methods: The medical records of 60 septic patients submitted to CRRT with the membrane oXiris from April 2011 to December 2018 have been reviewed. Read More

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http://dx.doi.org/10.1159/000499589DOI Listing
April 2019
1 Read

Extracorporeal Blood Purification Therapies for Sepsis.

Blood Purif 2019 11;47 Suppl 3:1-14. Epub 2019 Apr 11.

Full Professor of Nephrology, Department of Medicine, University of Padova, Vicenza, Italy.

Extracorporeal blood purification is proposed as an adjuvant therapy for sepsis, aiming at controlling the associated dysregulation of the immune system, which is known to induce organ dysfunctions. Different therapies have been developed to address certain steps of the immune dysregulation. Most of the available blood purification devices focus on a single target, such as the endotoxin that triggers the immune cascade, or the cytokine storm that causes organ damages. Read More

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http://dx.doi.org/10.1159/000499520DOI Listing
April 2019
1 Read

Introduction.

Authors:
Claudio Ronco

Blood Purif 2019 11;47 Suppl 3:1-2. Epub 2019 Apr 11.

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http://dx.doi.org/10.1159/000499786DOI Listing

oXirisNet Registry: A Prospective, National Registry on the oXiris Membrane.

Blood Purif 2019 04 11;47 Suppl 3:1-8. Epub 2019 Apr 11.

Department of Health Sciences, Section of Anesthesiology and Intensive Care, University of Florence, Florence, Italy.

Worldwide, the widespread use of extracorporeal blood purification therapies (EBPTs) is progressively increasing in everyday clinical practice, particularly in critical care settings. The efficacy of EBPTs on removal of inflammatory mediators is already well established in the literature. Nonetheless, clinical research is particularly cumbersome in this setting, and many clinical trials aiming at exploring the effect of EBPTs on outcomes have failed in demonstrating consistent results regarding 28-day- or hospital-mortality rates. Read More

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https://www.karger.com/Article/FullText/499356
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http://dx.doi.org/10.1159/000499356DOI Listing
April 2019
2 Reads

Counteracting the Metabolic Effects of Glucose Load in Peritoneal Dialysis Patients; an Exercise-Based Approach.

Blood Purif 2019 Apr 4:1-7. Epub 2019 Apr 4.

Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia, USA.

Glucose-based peritoneal dialysis (PD) solutions are the predominantly used dialysate in PD patients. Glucose absorption has been shown to be associated with several unfavorable metabolic complications. Several studies have shown positive effects of exercise in end-stage renal disease patients. Read More

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http://dx.doi.org/10.1159/000499406DOI Listing
April 2019
1 Read

Predilution On-Line Hemodiafiltration Improves Albumin Redox in Maintenance Hemodialysis Patients.

Blood Purif 2019 Apr 3;47 Suppl 2:1-6. Epub 2019 Apr 3.

Division of Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Background/aim: In this study, we compared the dialysis efficiency, oxidative stress, and nutritional conditions between predilution on-line hemodiafiltration (pre-OL-HDF) and conventional hemodialysis (HD) using a super-flux dialyzer (CHD).

Method: This was a crossover study of 38 maintenance HD patients. All patients were treated with CHD for the first 4 months (1st CHD period), then were switched to pre-OL-HDF for 4 months (pre-OL-HDF period), and were returned to CHD for the next 4 months (2nd CHD period). Read More

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http://dx.doi.org/10.1159/000496631DOI Listing
April 2019
1 Read

Strategies for the Super-Aged Dialysis Population: Survival Benefits or Alternative Goals?

Blood Purif 2019 Apr 3;47 Suppl 2:1-11. Epub 2019 Apr 3.

Department of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Tokyo, Japan.

Background/aims: Japan's aging population has prominent epidemiological and patient characteristics. The number of hemodialysis patients aged ≥70 years is increasing. Age-adjusted mortality is improving, but some cause-specific mortalities remain unchanged, including infectious disease and malignancy, requiring combative strategies. Read More

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http://dx.doi.org/10.1159/000496660DOI Listing
April 2019
3 Reads

Serum Magnesium Levels and Mortality in Japanese Maintenance Hemodialysis Patients.

Blood Purif 2019 Apr 3;47 Suppl 2:1-7. Epub 2019 Apr 3.

Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan,

Background/aims: Although hypomagnesemia was found to be a risk for cardiovascular diseases in the general population, the relationship between serum magnesium (Mg) levels and prognosis of patients on maintenance hemodialysis (MHD) has not been extensively studied. This study sought to determine the relationship of serum Mg levels with aortic arch calcification (AoAC) and mortality in Japanese MHD patients.

Methods: We measured serum Mg levels in a cohort of 392 patients on MHD, classified the patients into 3 groups according to these levels, and followed their course for 4 years. Read More

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http://dx.doi.org/10.1159/000496659DOI Listing
April 2019
18 Reads

Prevalence of Carnitine Deficiency and Decreased Carnitine Levels in Patients on Hemodialysis.

Blood Purif 2019 Apr 3;47 Suppl 2:1-7. Epub 2019 Apr 3.

Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan,

Background: Patients on hemodialysis (HD) are known to be at risk of carnitine deficiency. The aims of this study were to investigate the prevalence of carnitine deficiency in patients on dialysis and to compare the likelihood of a reduction in the serum carnitine level on HD with that on hemodiafiltration (HDF).

Methods: The prevalence of carnitine deficiency, defined as a serum free carnitine level < 20 μmol/L, and that of carnitine insufficiency, defined as an acyl/free carnitine ratio > 0. Read More

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http://dx.doi.org/10.1159/000496720DOI Listing

Medium Cut-Off Dialyzer versus Eight Hemodiafiltration Dialyzers: Comparison Using a Global Removal Score.

Blood Purif 2019 Apr 3:1-8. Epub 2019 Apr 3.

Department of Biochemistry, Hospital Clínic Barcelona, Barcelona, Spain.

Background: A novel class of membranes, medium cut-off (MCO) membranes, has recently been designed to achieve interesting removal capacities for middle and large middle molecules in hemodialysis (HD) treatments. The few studies published to date have reported contradictory results regarding middle-sized molecules when comparing MCO dialyzers versus dialyzers used in online hemodiafiltration (OL-HDF).

Methods: A prospective, single-center study was carried out in 22 patients. Read More

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http://dx.doi.org/10.1159/000499759DOI Listing
April 2019
5 Reads

Preface.

Blood Purif 2019 Apr 3;47 Suppl 2:1-2. Epub 2019 Apr 3.

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http://dx.doi.org/10.1159/000497532DOI Listing

Analysis of Extracellular Fluid Volume in Peritoneal Dialysis Patients before and after Kidney Transplantation.

Blood Purif 2019 Apr 3;47 Suppl 2:1-7. Epub 2019 Apr 3.

Department of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan,

Background/aims: To examine the relationship of extracellular fluid (ECF) volume and osmotic excess with treatment modality, we retrospectively analyzed spontaneous body weight loss and osmotic excretion versus true body weight after kidney transplantation in peritoneal dialysis (PD) patients and preemptive transplant recipients compared with hemodialysis (HD) patients. We also examined maximum bladder volume in other transplant recipients on PD.

Methods: From 2005 to 2011, 42 PD patients underwent kidney transplantation at our institution. Read More

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http://dx.doi.org/10.1159/000496639DOI Listing
April 2019
1 Read

Effect of Progression in Malnutrition and Inflammatory Conditions on Adverse Events and Mortality in Patients on Maintenance Hemodialysis.

Blood Purif 2019 Apr 3;47 Suppl 2:1-9. Epub 2019 Apr 3.

Department of Nephrology, Gojinkai-Sumiyoshigawa Hospital, Kobe, Japan.

Background/aim: In maintenance hemodialysis (MHD), protein-energy malnutrition and chronic inflammation can be critical and are two of the main causes of mortality.

Method: We compared the change in nutrition and inflammatory conditions between younger and older MHD patients during a 2-year period. Furthermore, using Kaplan-Meier analysis, we evaluated the correlations between changes in each parameter and any adverse events. Read More

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http://dx.doi.org/10.1159/000496629DOI Listing
April 2019
1 Read

Prevalence and Severity of Itching in Patients with End-Stage Renal Disease: Treatment with Nalfurafine Hydrochloride.

Blood Purif 2019 Apr 3;47 Suppl 2:1-5. Epub 2019 Apr 3.

Department of Nephrology, Tokorozawa Kidney Clinic, Saitama, Japan.

Background/aims: In this study, we investigated the severity and frequency of uremic pruritus and itch-associated insomnia in patients with end-stage renal disease (ESRD) or chronic kidney disease (CKD).

Methods: This questionnaire-based study included outpatients with ESRD or CKD who were attending Tokorozawa Renal Clinic in Saitama Prefecture or Musashi Ranzan Hospital and were stable on treatment. The questionnaire was completed by patients on hemodialysis (HD) before a dialysis session and by patients on peritoneal dialysis (PD) or conservative treatment at the time of an outpatient hospital visit. Read More

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http://dx.doi.org/10.1159/000496637DOI Listing

Inhibition of the Mammalian Target of Rapamycin May Augment the Increase in Soluble Klotho Levels in Renal Transplantation Recipients.

Blood Purif 2019 Apr 3;47 Suppl 2:1-7. Epub 2019 Apr 3.

Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine, Nishinomiya, Japan.

Background/aims: α-Klotho is mainly expressed in the kidneys, and its soluble form can prevent vascular calcifications. Inhibition of the mammalian target of rapamycin (mTOR) upregulates Klotho. We assessed serial changes in the levels of soluble Klotho (sKlotho) in recipients before and after renal transplantation and investigated the effects of an mTOR inhibitor. Read More

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http://dx.doi.org/10.1159/000496630DOI Listing
April 2019
3 Reads

Significance of Content of the Reticulocyte Hemoglobin in the Management of Renal Anemia.

Blood Purif 2019 Apr 3;47 Suppl 2:1-4. Epub 2019 Apr 3.

Maeda Institute of Renal Research, Kawasaki, Japan.

Optimal iron level in hemodialysis patients remains a subject of debate. The reticulocyte hemoglobin content (CHr) is believed to reflect the concentration of iron required in the most recent hematopoiesis in the bone marrow. CHr is not influenced by any factors that measure direct hemoglobin (Hb) of reticulocytes and is considered a reliable indicator. Read More

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http://dx.doi.org/10.1159/000496641DOI Listing
April 2019
3 Reads

Resistance to Erythropoiesis-Stimulating Agents in Pre-Dialysis and Post-Dialysis Mortality in Japanese Incident Hemodialysis Patients.

Blood Purif 2019 Apr 3;47 Suppl 2:1-7. Epub 2019 Apr 3.

Division of Nephrology, Toho University Ohashi Medical Center, Tokyo, Japan.

Background/aims: There is lack of definitive evidence about the association between erythropoiesis-stimulating agent (ESA) responsiveness in the pre-dialysis phase and mortality. Therefore, we conducted a hospital-based, retrospective, cohort study to assess the predictive value of ESA response for prognosis in incident hemodialysis patients.

Methods: A total of 108 patients without preexisting cardiovascular disease who had been started on maintenance hemodialysis were studied. Read More

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http://dx.doi.org/10.1159/000496634DOI Listing
April 2019
1 Read

Pre- and Postdialysis Uric Acid Difference and Risk of Long-Term All-Cause and Cardiovascular Mortalities in Japanese Hemodialysis Patients; Miyazaki Dialysis Cohort Study.

Blood Purif 2019 Apr 3;47 Suppl 2:1-6. Epub 2019 Apr 3.

Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Background/aims: Uric acid (UA) levels are affected by changes in dialysis; however, the relationship between the pre- and postdialysis UA difference (UAD) and mortality remains unclear.

Methods: A total of 1,073 patients receiving maintenance hemodialysis (HD) were enrolled in this cohort study and followed up for 5 years. Patients were divided into quartile categories according to baseline UAD. Read More

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http://dx.doi.org/10.1159/000496638DOI Listing

Aortic Arch Calcification and Bone-Associated Molecules in Peritoneal Dialysis Patients.

Blood Purif 2019 Apr 3;47 Suppl 2:1-7. Epub 2019 Apr 3.

Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan,

Background/aims: Aortic arch calcification (AoAC) is a fatal complication in dialysis. AoAC progression-related molecules in continuous ambulatory peritoneal dialysis (CAPD) remain unclear.

Methods: AoAC was estimated using plain chest radiography scoring (AoACS) in 30 CAPD patients (age 49. Read More

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http://dx.doi.org/10.1159/000496657DOI Listing
April 2019
1 Read

Differential Impacts of Intravenous Iron Administration and Iron-Containing Phosphate Binders on Serum Intact Fibroblast Growth Factor 23 Levels.

Blood Purif 2019 Apr 3;47 Suppl 2:1-7. Epub 2019 Apr 3.

Division of Nephrology, Department of Medicine, Showa University, School of Medicine, Tokyo, Japan.

Aims: This study assessed the impact of iron administration on serum fibroblast growth factor 23 (FGF23) levels.

Methods: Of 123 hemodialysis (HD) patients treated with erythropoiesis-stimulating agents, 22 received once-weekly intravenous iron and 17 received daily oral iron with iron-containing phosphate binders. Intact FGF23 and biomarkers of iron metabolism were measured from blood samples drawn before each HD session, at baseline and on days 3, 5, 7, and 14. Read More

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http://dx.doi.org/10.1159/000496640DOI Listing
April 2019
1 Read

Association between the Cardio-Ankle Vascular Index and Diabetes Mellitus-Related Peripheral Arterial Disease in Chronic Hemodialysis Patients.

Blood Purif 2019 Apr 3;47 Suppl 2:1-6. Epub 2019 Apr 3.

Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan.

Background: Peripheral arterial disease (PAD) has increased in association with the increase in the numbers of patients with kidney disease or diabetes. The aim of this study was to assess the prevalence of PAD in hemodialysis patients with diabetes.

Methods: To examine the usefulness of the cardio-ankle vascular index (CAVI) to screen for the presence of PAD, cross-sectional studies of 100 patients undergoing chronic hemodialysis were performed. Read More

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http://dx.doi.org/10.1159/000496632DOI Listing
April 2019
2 Reads

Complications During Continuous Renal Replacement Therapy in Critically Ill Neonates.

Blood Purif 2019 Apr 3;47 Suppl 2:1-7. Epub 2019 Apr 3.

Department of Pediatrics, School of Medicine, Iwate Medical University, Morioka, Japan.

Background/ Aims: Owing to practical and technical developments, continuous renal replacement therapy (CRRT) has been administered even in critically ill neonates. In this study, the complications in CRRT for neonates were examined to establish a safe CRRT.

Methods: This retrospective study reviewed the clinical records of neonates who underwent CRRT at our neonatal intensive care unit between 2009 and 2017. Read More

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http://dx.doi.org/10.1159/000496654DOI Listing
April 2019
2 Reads

Incidence, Risk factors, and Biomarkers Predicting Ischemic or Hemorrhagic Stroke Associated Acute Kidney Injury and Outcome: A Retrospective Study in a General Intensive Care Unit.

Blood Purif 2019 Mar 19:1-10. Epub 2019 Mar 19.

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China,

Objective: We investigated the epidemiology, risk factors, and predictive parameters for ischemic or hemorrhagic stroke-associated acute kidney injury (AKI) and mortality in a general intensive care unit (ICU) in China.

Methods: During 5 years, 479 stroke patients were screened, and 381 were enrolled. AKI was diagnosed within 7 days after ICU admission, based on the Kidney Disease Improving Global Outcomes criteria. Read More

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http://dx.doi.org/10.1159/000499029DOI Listing
March 2019
3 Reads

The Effect of Serum Neutrophil Gelatinase-Associated Lipocalin on the Discontinuation of Continuous Renal Replacement Therapy in Critically Ill Patients with Acute Kidney Injury.

Blood Purif 2019 Mar 7:1-8. Epub 2019 Mar 7.

Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China.

Background: To determine the optimal time for discontinuing continuous renal replacement therapy (CRRT) by evaluating serum neutrophil gelatinase-associated lipocalin (NGAL) in critically ill patients with acute kidney injury (AKI).

Methods: A prospective observational study was conducted from September 2015 to March 2018. AKI patients treated with CRRT for at least 24 h were divided into "success" and "failure" groups according to their RRT requirement within 7 days after the initial discontinuation of CRRT. Read More

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http://dx.doi.org/10.1159/000499026DOI Listing
March 2019
1 Read
1.920 Impact Factor

Burden, Access, and Disparities in Kidney Disease.

Blood Purif 2019 Mar 5:1-8. Epub 2019 Mar 5.

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.1159/000497498DOI Listing
March 2019
3 Reads

The Association between Long- and Intra-Dialytic Blood Pressure Variability with All-Cause Mortality in Hemodialysis Patients.

Blood Purif 2019 Feb 26:1-8. Epub 2019 Feb 26.

Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China,

Background: Blood pressure variability (BPV) is a potential prognostic predictor for all-cause mortality.

Objectives: We conducted a retrospective cohort study to compare the prognostic value of long-term BPV with intra-dialytic BPV in hemodialysis (HD) patients.

Materials And Methods: We included 611 HD patients and collected their baseline blood pressure (BP) measurements for 1 year and monitored them for 40 months. Read More

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https://www.karger.com/Article/FullText/496561
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http://dx.doi.org/10.1159/000496561DOI Listing
February 2019
6 Reads

Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients.

Blood Purif 2019 Feb 21:1-9. Epub 2019 Feb 21.

Department of Biostatistics, Faculty of Medicine, Erzincan University, Erzincan, Turkey.

Objectives: Aim of the study was investigating the effect of serum vitamin D levels on health-related quality of life in hemodialysis patients.

Method: One-hundred and twenty-three maintenance hemodialysis patients were enrolled in this cross-sectional study. Patients divided into 2 groups according to serum vitamin D levels. Read More

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http://dx.doi.org/10.1159/000497242DOI Listing
February 2019
2 Reads

Role of Lipoprotein Apheresis in Cardiovascular Disease Risk Reduction.

Blood Purif 2019 Feb 21:1-16. Epub 2019 Feb 21.

Division of Pediatric Nephrology, Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada.

Background And Aim: Elevated low-density lipoprotein cholesterol and/or lipoprotein(a) are established risk factors for cardiovascular disease (CVD). Management of hypercholesterolemia consists of drug therapies, including statins and proprotein convertase subtilisin/kexin type 9 inhibitors. In patients with familial hypercholesterolemia (FH), lipoprotein apheresis (LA) is utilized to control lipid levels. Read More

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http://dx.doi.org/10.1159/000497447DOI Listing
February 2019
1 Read

Misplacement of Tunneled Hemodialysis Catheter into Azygos Vein: Left or Right Jugular Insertion Has Similar Susceptibility.

Blood Purif 2019 Feb 14:1-9. Epub 2019 Feb 14.

Department of Nephrology, University of Hong Kong-Shenzhen Hospital, Shenzhen, China,

Background: Central venous catheter (CVC) is commonly used to provide access for hemodialysis (HD) when arteriovenous access is not available. The misplacement of CVC into azygos vein (AV) is a rare but a potential serious complication. Previous reports communicated the opinion that left-sided catheterization predisposed to AV misplacement, but these reports concentrated on peripherally inserted CVCs, placed for indications rather than HD. Read More

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http://dx.doi.org/10.1159/000497231DOI Listing
February 2019
1 Read

Uremic Patients with Increased Vascular Calcification Score Have Serum with High Calcific Potential: Role of Vascular Smooth Muscle Cell Osteoblastic Differentiation and Apoptosis.

Blood Purif 2019 Feb 6:1-8. Epub 2019 Feb 6.

Renal Division, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Milan, Italy,

Background/aims: Uremic patients experience premature vascular ageing that causes cardiovascular morbidity. In this study, we investigated the relationship between uremic serum calcific potential induced by high phosphate (Pi) and vascular calcification score (VCS).

Methods: Vascular smooth muscle cells (VSMCs) were cultured with 3. Read More

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http://dx.doi.org/10.1159/000497229DOI Listing
February 2019
3 Reads

Multi-Biomarkers Panel in Cardiac Surgery Patients.

Blood Purif 2019 Feb 6. Epub 2019 Feb 6.

IRRIV-International Renal Research Institute Vicenza, Vicenza, Italy.

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http://dx.doi.org/10.1159/000497230DOI Listing
February 2019

Chronic Kidney Disease: Exploring Value-Based Healthcare as a Potential Viable Solution.

Blood Purif 2019 1;47(1-3):156-165. Epub 2019 Feb 1.

Care Value Management EMEA, Fresenius Medical Care, Bad Homburg, Germany.

Background: Increasing healthcare expenditures have triggered a trend from volume to value by linking patient outcome to costs. This concept first described as value-based healthcare (VBHC) by Michael Porter is especially applicable for chronic conditions. This article aims to explore the applicability of the VBHC framework to the chronic kidney disease (CKD) care area. Read More

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http://dx.doi.org/10.1159/000496681DOI Listing
February 2019
1 Read

Maximum Glomerular Filtration Decline Rate is Associated with Mortality and Poor Renal Outcome in Chronic Kidney Disease Patients.

Blood Purif 2019 Feb 1:1-7. Epub 2019 Feb 1.

Division of Nephrology, Asia University Hospital, Taichung, Taiwan,

Background: Glomerular filtrate rate (GFR) decline is associated with increased risk of dialysis in patients with chronic kidney disease (CKD). It is unclear whether the maximum, the minimum, or the average of GFR decline rate is associated with the risk of mortality and the initiation of renal replacement therapy (RRT). We investigated prognostic role of the maximum, the minimum, and the average of GFR decline rate in patients with CKD not yet on dialysis. Read More

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http://dx.doi.org/10.1159/000496082DOI Listing
February 2019
1 Read

ACUsmart Continuous Renal Replacement Therapy Platform: Multicenter Pilot Study for Technical and Clinical Assessment (A.M.P. Study).

Blood Purif 2019 Feb 1:1-7. Epub 2019 Feb 1.

Department of Nephrology, Dialysis and Transplantation and International Renal Research Institute of Vicenza, San Bortolo Hospital, Vicenza, Italy.

Background: ACUsmart (Medica S.P.A. Read More

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http://dx.doi.org/10.1159/000496090DOI Listing
February 2019
10 Reads

Sclerostin/Receptor Related Protein 4 and Ginkgo Biloba Extract Alleviates β-Glycerophosphate-Induced Vascular Smooth Muscle Cell Calcification By Inhibiting Wnt/β-Catenin Pathway.

Blood Purif 2019 30;47 Suppl 1:17-23. Epub 2019 Jan 30.

Department of Nephrology, The First Hospital of China Medical University, Shenyang, China,

Background: Abnormal mineral metabolism in patients with chronic kidney disease (CKD) may lead to vascular calcification, which is markedly associated with adverse events, including ischemic cardiac diseases and all-cause cardiovascular mortality. Thus, preventing and treating vascular calcification play an important role in improving the prognosis of CKD patients.

Objectives: To investigate the potential functions of sclerostin and low-density lipoprotein receptor-related protein 4 (Lrp4) in alleviating the β-glycerophosphate (β-GP)-induced vascular smooth muscle cell (VSMC) calcification, and the protective effect of Ginkgo biloba extract (GBE). Read More

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http://dx.doi.org/10.1159/000496219DOI Listing
January 2019
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1.920 Impact Factor

Study on the Prevalence of Vascular Calcification in Different Types of Arteries and Influencing Factors in Maintenance Peritoneal Dialysis Patients.

Blood Purif 2019 30;47 Suppl 1:8-16. Epub 2019 Jan 30.

Department of Nephrology, Peking University People's Hospital, Beijing, China.

Objective: To investigate the occurrence of vascular calcification (VC) in different types of arteries in patients with maintenance peritoneal dialysis (PD) patients and its influencing factors.

Methods: This study enrolled PD patients with stable status who has received PD treatment for more than 6 months in Peking University People's Hospital. We used plain X-ray films of abdomen, pelvis, and hands to quantitatively evaluate VC of large artery (abdominal aorta, iliac artery), medium artery (femoral artery, radial artery), and small artery (finger arteries). Read More

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http://dx.doi.org/10.1159/000496218DOI Listing
January 2019
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Improved Control of Secondary Hyperparathyroidism in Hemodialysis Patients Switching from Oral Cinacalcet to Intravenous Etelcalcetide, Especially in Nonadherent Patients.

Blood Purif 2019 Jan 30:1-9. Epub 2019 Jan 30.

Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona, Spain,

Background: Etelcalcetide is a novel second-generation calcimimetic that, because of its intravenous administration, could improve treatment adherence in secondary hyperparathyroidism (SHPT). The aim of this study was to evaluate the effectiveness of etelcalcetide compared with that of cinacalcet in controlling SHPT in patients under hemodialysis.

Methods: A prospective observational study was performed in 29 patients with SHPT under hemodialysis who switched from cinacalcet to etelcalcetide with a follow-up of 6 months. Read More

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http://dx.doi.org/10.1159/000496562DOI Listing
January 2019
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Effects of Multidisciplinary Team Care Based on 5E's Renal Rehabilitation for Peritoneal Dialysis Patients in Guangxi Zhuang Autonomous Region of China: A Randomized Controlled Trial.

Blood Purif 2019 Jan 30:1-9. Epub 2019 Jan 30.

Department of Nutritional, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background: The number of patients with peritoneal dialysis (PD) in China has been increasing year after year, but there are still some challenge in the management of PD patients, and the efficient and effective method has yet to be developed. Multidisciplinary team (MDT) is to create a standardized, individualized, and continuous integrated treatment program for the patients, to ensure the best efficacy and improve patient outcomes. 5E's renal rehabilitation was originally developed by the Life Options Rehabilitation Advisory Council in 1997 to achieve better management of PD patients. Read More

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http://dx.doi.org/10.1159/000496823DOI Listing
January 2019

Meta-Analysis of the Association between Fibroblast Growth Factor 23 and Mortality and Cardiovascular Events in Hemodialysis Patients.

Blood Purif 2019 30;47 Suppl 1:24-30. Epub 2019 Jan 30.

Departments of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Introduction: This study was conducted to ensure the correlation between fibroblast growth factor 23 (FGF23) and death and cardiovascular events in hemodialysis patients.

Methods: We conducted a literature search of PubMed database to April 2018 for relevant articles that reported the association between FGF23 and risk of all-cause mortality and cardiovascular disease (CVD) events. The meta-analysis was performed using the Revman 5. Read More

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http://dx.doi.org/10.1159/000496220DOI Listing
January 2019
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Clearance of Magnesium in Peritoneal Dialysis Patients: A Single-Center Study.

Blood Purif 2019 30;47 Suppl 1:1-7. Epub 2019 Jan 30.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: This retrospective study aimed to investigate the clearance of magnesium (Mg) in peritoneal dialysis (PD) patients and its influencing factors.

Methods: The demographic information, clinical characteristics and laboratory data of the patients were collected. According to the corrected serum Mg (cS-Mg) concentration, patients were divided into 3 groups including hypomagnesemia (Mg2+ < 0. Read More

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http://dx.doi.org/10.1159/000496217DOI Listing
January 2019
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Ectopic Calcification of Fibrin Sheath on the Catheter.

Blood Purif 2019 Jan 30:1-3. Epub 2019 Jan 30.

Department of Kidney Disease and Blood Purification, Institute of Urology and Key Laboratory of Tianjin, The Second Hospital of Tianjin Medical University, Tianjin, China,

We describe a case of hemodialysis catheter that appeared to be encased in a sleeve-shaped fibrous sheath with calcification. Ectopic calcification is a serious complication in hemodialysis patients with calcium-phosphorus metabolism disorder. Clinical awareness and understanding of this condition is imperative to the prevention and management of ectopic calcification. Read More

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https://www.karger.com/Article/FullText/496231
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http://dx.doi.org/10.1159/000496231DOI Listing
January 2019
7 Reads

Differential Molecular Modeling Predictions of Mid and Conventional Dialysate Flows.

Blood Purif 2019 Jan 30:1-8. Epub 2019 Jan 30.

Palo Alto Medical Foundation, Palo Alto, California, USA,

Background: High dialysate flow rates (QD) of 500-800 mL/min are used to maximize urea removal during conventional hemodialysis. There are few data describing hemodialysis with use of mid-rate QD (300 mL/min).

Methods: We constructed uremic solute (urea, beta2-microglobulin and phosphate) kinetic models at varying volumes of distribution and blood flow rates to predict solute clearances at QD of 300 and 500 mL/min. Read More

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http://dx.doi.org/10.1159/000495022DOI Listing
January 2019
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Effects of Peritoneal Dialysis on Clinical Factors and Functional Performance.

Blood Purif 2019 Jan 30:1-7. Epub 2019 Jan 30.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan,

Background: We investigated the longitudinal trend of functional performance in peritoneal dialysis (PD) patients over 1 year after PD commencement and its related clinical parameters.

Methods: One hundred and ninety-six PD patients were enrolled in this study. Karnofsky Performance Status Scale(KPSS) scores were used to assess functional performance. Read More

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https://www.karger.com/Article/FullText/496081
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http://dx.doi.org/10.1159/000496081DOI Listing
January 2019
9 Reads