120,674 results match your criteria Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis[Journal]


Biochemical Changes in Blood of Patients with Duchenne Muscular Dystrophy Treated with Granulocyte-Colony Stimulating Factor.

Biomed Res Int 2019 13;2019:4789101. Epub 2019 Mar 13.

Department of Pediatric Radiology, Medical University of Bialystok, Bialystok, Poland.

Introduction: In addition to the "gold standard" of therapy-steroids and gene therapy-there are experimental trials using granulocyte-colony stimulating factor (G-CSF) for patients with Duchenne muscular dystrophy (DMD). The aim of this study was to present the biochemical changes in blood after repeating cycles of granulocyte-colony stimulating factor G-CSF therapy in children with DMD.

Materials And Methods: Nineteen patients, aged 5 to 15 years, with diagnosed DMD confirmed by genetic tests, participated; nine were in wheelchairs, and ten were mobile and independent. Read More

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http://dx.doi.org/10.1155/2019/4789101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436375PMC

In Vitro Antiatherothrombotic Effects of Extracts from L., L., and Benth.

Evid Based Complement Alternat Med 2019 14;2019:3245836. Epub 2019 Mar 14.

Food and Science Technology Research Centre, MARDI, Serdang, Selangor, Malaysia.

Coronary artery disease is the leading cause of mortality and morbidity worldwide. The pathogenesis is mainly due to atherosclerosis, plaque rupture, and platelet thrombus formation. The main risk factors for coronary artery disease include obesity, hypercholesterolemia, smoking, diabetes, and high blood pressure. Read More

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http://dx.doi.org/10.1155/2019/3245836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437728PMC

Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys ().

Int J Endocrinol 2019 13;2019:2047803. Epub 2019 Mar 13.

Laboratory of Neuroscience and Behaviour, University of Brasilia, Brasilia, Brazil.

This study aimed at evaluating the availability of the primate as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female from the Primate Research Center of the University of Brasília were selected to take part in this experiment. Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment. Read More

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http://dx.doi.org/10.1155/2019/2047803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436371PMC

Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model.

Front Immunol 2019 2;10:619. Epub 2019 Apr 2.

Hematology Research Unit, GIGA-I3, GIGA Institute, University of Liège, Liège, Belgium.

Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft- vs.-host disease (GVHD). However, despite promising results in phase I/II studies, bone marrow (BM-) derived MSCs failed to demonstrate their superiority over placebo in the sole phase III trial reported thus far. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00619
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http://dx.doi.org/10.3389/fimmu.2019.00619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454068PMC
April 2019
1 Read

Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms.

Sci Rep 2019 Apr 18;9(1):6272. Epub 2019 Apr 18.

Division of Cancer-Hull York Medical School, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.

The bidirectional association between coagulation and cancer has been established. However, anticoagulant therapies have been reported to have beneficial outcomes by influencing the vascularisation of the tumours. In this study the influence of a set of anticoagulants on tumour formation, invasion and vascularisation was examined. Read More

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http://dx.doi.org/10.1038/s41598-019-42738-1DOI Listing

Vitamin K deficiency-induced hemorrhagic shock after thoracentesis: a case report.

BMC Gastroenterol 2019 Apr 18;19(1):58. Epub 2019 Apr 18.

Honjoudaiichi Hospital, 110, Iwabuchishita, Yurihonnjou, Akita, 015-8567, Japan.

Background: Vitamin K deficiency results in serious coagulation dysfunction, but hemorrhagic shock is rare. Herein, we describe a case of vitamin K deficiency and abnormality in the path of the intercostal artery, the combination of which led to hemorrhagic shock.

Case Presentation: An 83-year-old woman was hospitalized for suspected gallstones. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0978-0DOI Listing
April 2019
1 Read

Surgical Risk on Patients with Coagulopathies: Guidelines on Hemophiliac Patients for Oro-Maxillofacial Surgery.

Int J Environ Res Public Health 2019 Apr 17;16(8). Epub 2019 Apr 17.

Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy.

Background: Haemophilia is a disease of genetic origin, which causes a defect in blood coagulation. Under normal conditions, in the case of leakage from the blood vessels, the blood forms a clot that reduces or blocks the bleeding. This process involves the activation of several plasma proteins in a cascade-like species. Read More

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http://dx.doi.org/10.3390/ijerph16081386DOI Listing

Engineered Electrospun Polyurethane Composite Patch Combined with Bi-functional Components Rendering High Strength for Cardiac Tissue Engineering.

Polymers (Basel) 2019 Apr 17;11(4). Epub 2019 Apr 17.

Media and Game Innovation Centre of Excellence (MaGICX), Institute of Human Centered Engineering (iHumEn), Universiti Teknologi Malaysia, Skudai 81310, Malaysia.

Cardiovascular application of nanomaterial's is of increasing demand and its usage is limited by its mechanical and blood compatible properties. In this work, an attempt is made to develop an electrospun novel nanocomposite loaded with basil oil and titanium dioxide (TiO) particles. The composite material displayed increase in hydrophobic and reduced fiber diameter compared to the pristine polymer. Read More

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https://www.mdpi.com/2073-4360/11/4/705
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http://dx.doi.org/10.3390/polym11040705DOI Listing
April 2019
1 Read

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

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April 2019
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Clampless and sutureless laparoscopic partial nephrectomy using monopolar coagulation with or without N-butyl-2-cyanoacrylate.

World J Surg Oncol 2019 Apr 17;17(1):72. Epub 2019 Apr 17.

Department of Urology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, China.

Objective: To describe a novel technique for clampless and sutureless laparoscopic partial nephrectomy (LPN) using monopolar coagulation with or without N-butyl-2-cyanoacrylate (NBCA).

Methods: From February 2015 to October 2018, we performed clampless and sutureless LPN using monopolar coagulation with or without NBCA on 142 patients. The tumors were resected with cold scissor. Read More

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http://dx.doi.org/10.1186/s12957-019-1614-8DOI Listing

Entecavir-Associated Thrombocytopenia: A Case Report and Review of the Pathophysiology, Diagnosis, and Treatment of a Rare but Reversible Cause of Thrombocytopenia.

Case Rep Hematol 2019 12;2019:4319148. Epub 2019 Mar 12.

Department of Internal Medicine, Texas Health Presbyterian Hospital, Dallas, Texas 75231, USA.

Drug-associated thrombocytopenia is often unrecognized. We report a 76-year-old female with lymphoma who presented with easy bruising and oral bleeding. She had undergone screening for hepatitis B virus (HBV) prior to starting rituximab and was found to have hepatitis B core serum antibody (IgG anti-HBc). Read More

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https://www.hindawi.com/journals/crihem/2019/4319148/
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http://dx.doi.org/10.1155/2019/4319148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434310PMC
March 2019
1 Read

Probing prothrombin structure by limited proteolysis.

Sci Rep 2019 Apr 16;9(1):6125. Epub 2019 Apr 16.

Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, 63104, USA.

Prothrombin, or coagulation factor II, is a multidomain zymogen precursor of thrombin that undergoes an allosteric equilibrium between two alternative conformations, open and closed, that react differently with the physiological activator prothrombinase. Specifically, the dominant closed form promotes cleavage at R320 and initiates activation along the meizothrombin pathway, whilst the open form promotes cleavage at R271 and initiates activation along the alternative prethrombin-2 pathway. Here we report how key structural features of prothrombin can be monitored by limited proteolysis with chymotrypsin that attacks W468 in the flexible autolysis loop of the protease domain in the open but not the closed form. Read More

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http://dx.doi.org/10.1038/s41598-019-42524-zDOI Listing

Thrombomodulin Regulation of Mitogen-Activated Protein Kinases.

Int J Mol Sci 2019 Apr 15;20(8). Epub 2019 Apr 15.

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

The multifaceted role of mitogen-activated protein kinases (MAPKs) in modulating signal transduction pathways in inflammatory conditions such as infection, cardiovascular disease, and cancer has been well established. Recently, coagulation factors have also emerged as key players in regulating intracellular signaling pathways during inflammation. Among coagulation factors, thrombomodulin, as a high affinity receptor for thrombin on vascular endothelial cells, has been discovered to be a potent anti-inflammatory and anti-tumorigenic signaling molecule. Read More

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http://dx.doi.org/10.3390/ijms20081851DOI Listing

[Clinical efficacy of Bushen Huoxue Anshen therapy in treating perimenopausal sleep disorder with kidney deficiency and blood stasis].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1069-1074

Traditional Chinese Medicine Hospital of Huairou District Beijing 101400,China.

The efficacy and safety of traditional Chinese medicine and acupuncture in the treatment of kidney-deficiency and bloodstasis perimenopausal sleep disorders were evaluated. A total of 67 subjects who completed the study were randomly divided into two groups. The traditional Chinese medicine group was orally given Bushen Huoxue Anshen Fang,and the acupuncture group was given acupuncture treatment. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181225.002DOI Listing

[Nature-effect relationship research of Curcumae Longae Rhizoma,Curcumae Radix,and Curcumae Rhizoma based on nature combination].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):229-234

State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.

Curcumae Longae Rhizoma,Curcumae Radix and Curcumae Rhizoma are different medicinal parts of the same plant.Nevertheless,they are different in medicinal effects due to the different Chinese herbal nature. In this study,traditional Chinese medicines database( TCMD2009),traditional Chinese medicine system( TCMSP),and Ch EMBL database were retrieved to screen the active components and targets,and construct the target PPI network. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20180903.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180903.003DOI Listing
January 2019
1 Read

[Nature-effect relationship research of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos based on nature combination].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):224-228

State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.

Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are commonly traditional Chinese medicines with invigorating blood circulation and eliminating blood stasis,but they are different in effects due to differences in five tastes and four properties. In this study,Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are selected as research vectors to obtain the active ingredients and targets through TCMD,TCMSP database and Ch EMBL database. The protein interaction information of the target is used to obtain from STRING online database,then imported into Cytoscape software to plot the protein interaction network and perform GO enrichment analysis. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180903.002DOI Listing
January 2019

[Nature-effect relationship research of cold and warm medicinal properties of traditional Chinese medicine for promoting blood circulation and removing blood stasis based on nature combination].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):212-217

State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.

Traditional Chinese medicine for promoting blood circulation and removing blood stasis is a kind of drug with cold or warm medicinal properties which is commonly used in clinical practice. It is an excellent carrier for studying the nature-effect relationship of traditional Chinese medicine. Therefore,this study will acquire the main active components and targets based on the drug-based research method. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20180903.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180903.001DOI Listing
January 2019
3 Reads

[Nature-effect relationship research of traditional Chinese medicine for promoting blood circulation and removing blood stasis based on nature combination].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):205-211

State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.

The efficacy of traditional Chinese medicine is the therapeutic effect of the drug on the body. The nature of traditional Chinese medicine is a further generalization of the effect of efficacy,and there is an intrinsic relationship between efficacy and nature of traditional Chinese medicine. In this study,the nature-effect relationship is found on the whole level,through the research mode of " nature combination-targets of traditional Chinese medicine-modules of protein interaction network-efficiency". Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180913.001DOI Listing
January 2019

[Blood-cooling and hemostasis effects of Rehmanniae Radix before and after carbonizing].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(5):954-961

College of Traditional Chinese Medicine,Shanxi University of Chinese Medicine Jinzhong 030619,China.

To compare the blood-cooling and hemostasis effects of Rehmanniae Radix before and after carbonizing on rats with blood heat and hemorrhage syndrome. The blood heat and hemorrhage syndrome rat model was established. Indexes including rectal temperature,whole blood viscosity,plasma viscosity,thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen content(FIB),red blood cell(RBC),hemoglobin(Hb),hematocrit(HCT),blood platelet count(PLT),mean platelet volume(MPV),serum IL-1,serum IL-6 and lung histopathology were detected to investigate the blood-cooling and hemostasis effects of Rehmanniae Radix and its carbonized products. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181221.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181221.007DOI Listing
March 2019
1 Read

Pancytopenia as a Consequence of Sepsis and Intravenous Antibiotic Drug Toxicity.

Cureus 2019 Feb 1;11(2):e3994. Epub 2019 Feb 1.

Internal Medicine, Ocala Regional Medical Center/ University of Central Florida College of Medicine, Ocala, USA.

This case involves a 62-year-old male with a prior history of epidural abscess and L1-L2 osteodiscitis who was admitted because of low back pain. The patient was previously treated for methicillin-susceptible Staphylococcus aureus (MSSA) discitis in the L1/L2 vertebral region with intravenous (IV) nafcillin through a peripherally inserted central catheter (PICC). However, he returned after four months with recurrent low back pain along with chills and fever. Read More

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https://www.cureus.com/articles/17399-pancytopenia-as-a-cons
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http://dx.doi.org/10.7759/cureus.3994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443538PMC
February 2019
1 Read

Application value of thromboelastography in perioperative clinical blood transfusion and its effect on the outcome of patient.

Exp Ther Med 2019 May 1;17(5):3483-3488. Epub 2019 Mar 1.

Department of Intensive Care Unit, Central Hospital of Zibo, Zibo, Shandong 255000, P.R. China.

Application value of thromboelastography (TEG) in perioperative clinical blood transfusion and its effect on the outcome of patient were investigated. Seventy-four patients, admitted to The Surgical Department of the First Hospital of Zibo from March 2015 to March 2018, were selected for this study. Among them, 34 patients took only the traditional coagulation function testing method as the blood transfusion guide during the perioperative period and they were regarded as the control group. Read More

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http://dx.doi.org/10.3892/etm.2019.7333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447791PMC

Efficacy of Thromboelastography (TEG) in Predicting Acute Trauma-Induced Coagulopathy (ATIC) in Isolated Severe Traumatic Brain Injury (iSTBI).

Indian J Hematol Blood Transfus 2019 Apr 11;35(2):325-331. Epub 2018 Aug 11.

4Department of Emergency Medicine, Jai Prakash Narayan Apex Trauma Center, AIIMS, New Delhi, India.

To evaluate the efficacy of point-of-care thromboelastography (TEG) to predict acute trauma-induced coagulopathy (ATIC) in isolated severe TBI (iSTBI). We conducted an observational diagnostic cohort. Patients for whom TEG was performed before blood transfusion were stratified by conventional coagulation tests (CCTs) on admission and classified as "ATIC" (prothrombin time ≥ 16. Read More

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http://dx.doi.org/10.1007/s12288-018-1003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439129PMC

Reduced Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 is Associated with Disturbed Coagulation in Septic Shock.

Thromb Haemost 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

Background:  Activation of the complement system is part of the dysregulated immune response in sepsis. The mannose-binding lectin-associated serine proteases (MASP)-1 and -2 activate the lectin pathway of the complement system. Besides, these proteins can activate coagulation in vitro. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685140
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http://dx.doi.org/10.1055/s-0039-1685140DOI Listing
April 2019
2 Reads

PEGAylated graphene oxide/superparamagnetic nanocomposite as a high-efficienc loading nanocarrier for controlled delivery of methotrexate.

J Biotechnol 2019 Apr 12. Epub 2019 Apr 12.

Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, 81746-73441, Iran.

Polymer-coated nanocarriers play an important role in targeted drug delivery. The use of polymers such as polyethylene glycol increases stability, biocompatibility, and blood circulation time of the drug, and may consequently improve the success of drug delivery. In the present work, a simple approach has been reported for synthesizing polyethylene glycol bis amin (PEGA) functionalized graphene oxide/iron oxide nanocomposite as a remarkable unit for loading drugs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681656193012
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http://dx.doi.org/10.1016/j.jbiotec.2019.04.006DOI Listing
April 2019
1 Read

Impact of low volume citrate tubes on results of first-line hemostasis testing.

Int J Lab Hematol 2019 Apr 15. Epub 2019 Apr 15.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

Introduction: Pediatric tubes are increasingly used for drawing blood for hemostasis testing. This study has investigated the potential impact of low volume citrate tubes on results of first-line hemostasis testing.

Methods: The study population comprised 34 patients on warfarin therapy and 17 ostensibly healthy volunteers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijlh.13028
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http://dx.doi.org/10.1111/ijlh.13028DOI Listing
April 2019
1 Read

Trauma-Induced Coagulopathy: The Past, Present, and Future.

J Thromb Haemost 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Denver Health Medical Center and the University of Colorado, 777 Bannock Street. Mail Code 0206, Denver, CO, 80203.

Trauma remains a leading cause of death worldwide, and most early preventable deaths in both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm advances in modern trauma care. Combined tissue injury and shock result in hemostatic failure, which has been identified as a multi-dimensional molecular, physiologic, and clinical disorder termed trauma-induced coagulopathy (TIC). Understanding the biology of TIC is of utmost importance as it is often responsible for uncontrolled bleeding, organ failure, thromboembolic complications, and death. Read More

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http://dx.doi.org/10.1111/jth.14450DOI Listing
April 2019
1 Read

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction.

J Vis Exp 2019 Apr 1(146). Epub 2019 Apr 1.

Carones Ophthalmology Center.

Dry eye disease (DED) is an increasingly common condition and one of the most common complaints of patients. The vast majority of DED is caused by the so-called "evaporative" subtype, that is mainly caused by meibomian gland dysfunction (MGD). Intense pulsed light (IPL) devices employ high intensity pulses of polychromatic lights with a broad range of wavelength (515-1200 nm). Read More

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http://dx.doi.org/10.3791/57811DOI Listing
April 2019
2 Reads

Review of herbal medications with the potential to cause bleeding: dental implications, and risk prediction and prevention avenues.

Authors:
Worku Abebe

EPMA J 2019 Mar 8;10(1):51-64. Epub 2019 Jan 8.

Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, CL-2130, Augusta, GA 30912-1128 USA.

Medicinal plant products have been used in health care since time immemorial. During the past three decades, the use of herbal supplements has been on the rise in the USA. A number of these products have been shown to possess the potential to interfere with blood clotting. Read More

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http://link.springer.com/10.1007/s13167-018-0158-2
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http://dx.doi.org/10.1007/s13167-018-0158-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459456PMC
March 2019
1 Read

The Antioxidative Action of ZTP by Increasing Nrf2/ARE Signal Pathway.

Evid Based Complement Alternat Med 2019 10;2019:5421528. Epub 2019 Mar 10.

School of Life Science, Beijing Institute of Technology, Beijing 100081, China.

So far, more than 25,000 brain diseases have been shown to be related to oxidative stress. Excessive free radicals and reactive oxygen species (ROS) can attack cells resulting in dysfunctional proteins, lipids, and nucleic acid, finally leading to imbalance of energy metabolism, cell death, gene mutation, and immune reaction. Therefore oxidative stress plays an important role in neuronal diseases. Read More

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https://www.hindawi.com/journals/ecam/2019/5421528/
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http://dx.doi.org/10.1155/2019/5421528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431467PMC
March 2019
2 Reads

Efficacy and complications of argon plasma coagulation for hemorrhagic chronic radiation proctitis.

World J Gastroenterol 2019 Apr;25(13):1618-1627

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China.

Background: Chronic radiation proctitis (CRP) is a complication which occurs in 1%-5% of patients who undergo radiotherapy for pelvic malignancies. Although a wide range of therapeutic modalities are available, there is no literature to date showing any particularly appropriate therapeutic modality for each disease stage. Argon plasma coagulation (APC) is currently recommended as the first-choice treatment for hemorrhagic CRP, however, its indication based on long-term follow-up is still unclear. Read More

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http://dx.doi.org/10.3748/wjg.v25.i13.1618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452229PMC

[Structural control and characterization of hierarchically structured fibrous scaffolds].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):479-485

Key Laboratory of Textile Science & Technology, Ministry of Education, Textile College of Donghua University, Shanghai, 201620, P.R.China.

Objective: To prepare hierarchically structured fibrous scaffolds with different morphologies, and to explore the additional dimensionality for tuning the physicochemical properties of the scaffolds and the effect of their hemocompatibility and cytocompatibility.

Methods: Electrospinning poly (e-caprolactone) (PCL)/polyvinylpyrrolidone (PVP) bicomponent fibers (PCL∶PVP mass ratios were 8∶2 and 5∶5 respectively), and the surface porous fibrous scaffolds were prepared by extracting PVP components. The scaffolds were labeled PCL-P8 and PCL-P5 respectively according to the mass ratio of polymer. Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201808128
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http://dx.doi.org/10.7507/1002-1892.201808128DOI Listing
April 2019
1 Read

Methanolic root extract of Codonopsis clematidea prevents hypoxia induced procoagulant state by inhibition of GPIb receptor regulated Lyn kinase activation.

Phytomedicine 2019 Mar 27;59:152903. Epub 2019 Mar 27.

Defence Institute of Physiology and Allied Sciences, Delhi, 110054, India.

Background: The prevalence of procoagulant state under prolonged hypoxic exposures and the complications and lack of specificity associated with use of existing anti-thrombotic agents have necessitated the search for safer and natural therapeutics. Codonopsis, a widely studied medicinal herb, has been reported to decrease whole blood viscosity but the bioactive ingredients involved, and their mechanism of action therein however remain to be investigated.

Purpose: The present study aimed at evaluating the efficacy of C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113193007
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http://dx.doi.org/10.1016/j.phymed.2019.152903DOI Listing
March 2019
2 Reads
3.126 Impact Factor

Platelet enhancement of bacterial growth during room temperature storage: mitigation through refrigeration.

Transfusion 2019 Apr;59(S2):1479-1489

U.S. Army Institute of Surgical Research, Coagulation and Blood Research Task Area, Texas.

Introduction: Due to high risk of septic transfusion reactions arising from bacterial contamination, US Food and Drug Administration regulations currently limit platelet storage to 5 days at room temperature (RT). However, blood culturing methods can take up to 7 days to detect bacteria, allowing transfusion of potentially contaminated units. Thus, cold storage (CS) may be a viable means of extending shelf life and improving safety. Read More

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http://dx.doi.org/10.1111/trf.15255DOI Listing

Effect of leukoreduction and pathogen reduction on the hemostatic function of whole blood.

Transfusion 2019 Apr;59(S2):1539-1548

Department of Pediatrics, Division of Pediatric Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri.

Background: There is renewed interest in the use of whole blood (WB) for resuscitation of patients in hemorrhagic shock. Leukoreduction with platelet-sparing filters and pathogen reduction may be used to improve the safety profile of WB, yet the effects of leukoreduction and pathogen reduction on WB hemostatic function are not well characterized.

Study Design And Methods: Blood from 32 healthy group O donors was divided into treatment groups (n = 8 for each group): untreated, pathogen reduced (PR ), leukoreduced using an in-line filter (LR ), or PR LR . Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.15175
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http://dx.doi.org/10.1111/trf.15175DOI Listing
April 2019
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Optimizing whole blood storage: hemostatic function of 35-day stored product in CPD, CP2D, and CPDA-1 anticoagulants.

Transfusion 2019 Apr;59(S2):1549-1559

United States Army Institute of Surgical Research, JBSA-Fort Sam Houston, Texas.

Background: Transitioning from whole blood (WB) to components developed from efforts to maximize donor yield. Components are advantageous for specific derangements, but treating hemorrhage with components requires significantly more volume to provide similar effects to WB. Because storage lesion and waste remain problematic, this study examined hemostatic function of refrigerated WB stored for 35 days in anticoagulants citrate-phosphate-dextrose-adenosine (CPDA-1), citrate-phosphate-dextrose (CPD), or citrate-phosphate-double dextrose (CP2D). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.15164
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http://dx.doi.org/10.1111/trf.15164DOI Listing
April 2019
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Human primary fibroblasts perform similarly to MSCs in assays used to evaluate MSC safety and potency.

Transfusion 2019 Apr;59(S2):1593-1600

Coagulation & Blood Research, US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.

Background: Cellular therapeutic agents may benefit trauma patients by modulating the immune response to injury, and by reducing inflammation and vascular leakage. Administration of allogeneic mesenchymal stromal cells (MSCs) shows some benefit in preclinical and clinical trials, but less testing has been performed with other cell types. Human primary fibroblasts (FBs) were compared to MSCs in assays designed to evaluate MSCs to determine if these assays actually evaluate properties unique to MSCs or whether related cell types perform similarly. Read More

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http://dx.doi.org/10.1111/trf.15187DOI Listing

A prospective evaluation of thromboelastometry (ROTEM) to identify acute traumatic coagulopathy and predict massive transfusion in military trauma patients in Afghanistan.

Transfusion 2019 Apr;59(S2):1601-1607

Coagulation and Blood Research Program, US Army Institute of Surgical Research, FT Sam Houston, Texas.

Background: Hemorrhage is the leading cause of preventable trauma-related mortality and is frequently aggravated by acute traumatic coagulopathy (ATC). Viscoelastic tests such as rotational thromboelastometry (ROTEM) may improve identification and management of ATC. This study aimed to prospectively evaluate changes in ROTEM among combat casualties during the first 24 hours and compare the capabilities of our conventional clotting assay (international normalized ratio [INR], >1. Read More

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http://dx.doi.org/10.1111/trf.15176DOI Listing

Evaluation of a lyophilized platelet-derived hemostatic product.

Transfusion 2019 Apr;59(S2):1490-1498

Coagulation and Blood Research Program, U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas.

Background: Current limitations of platelet shelf life to 5 days have led to an increasingly greater demand for hemostatic agents with greater longevity. The objective of this study was to evaluate the function of a lyophilized platelet-derived hemostatic product (thrombosome [TS]) as a potential alternative to fresh platelets.

Methods: Platelets were collected from whole blood from healthy donors. Read More

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http://dx.doi.org/10.1111/trf.15167DOI Listing
April 2019
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[Sex and gender-specific aspects in prediabetes and diabetes mellitus-clinical recommendations (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Interne Abteilung, Landeskrankenhaus Hochzirl - Natters, Hochzirl, Österreich.

Metabolic diseases dramatically affect the life of men and women from infancy up to old age in different and manifold ways and are a major challenge for the healthcare system. The treating physicians are confronted with the different needs of women and men in the clinical routine. Gender-specific differences affect screening, diagnostic and treatment strategies as well as the development of complications and mortality rates. Read More

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http://dx.doi.org/10.1007/s00508-018-1421-1DOI Listing

Effect of Liver Disease Etiology on ROTEM Profiles in Patients Undergoing Liver Transplantation.

Transplant Proc 2019 Apr 9;51(3):783-789. Epub 2019 Jan 9.

Department of Anaesthetics, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK.

Background: Coagulation abnormalities in liver transplant patients are complex and may be related to the underlying liver disease. We evaluated the effects of disease etiology on whole-blood rotational thromboelastometry (ROTEM; Pentapharm GmbH, Munich, Germany) profile and association with thrombotic complications following liver transplantation.

Methods: Analysis of perioperative data from patients undergoing liver transplantation between January 1, 2012 and December 31, 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183131
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http://dx.doi.org/10.1016/j.transproceed.2018.12.030DOI Listing
April 2019
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Graft Neutrophil Sequestration and Concomitant Tissue Plasminogen Activator Release During Reperfusion in Clinical Kidney Transplantation.

Transplant Proc 2019 Apr 26;51(3):647-650. Epub 2019 Jan 26.

Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Inflammation, coagulation, and fibrinolysis are tightly linked together. Reperfusion after transient ischemia activates both neutrophils, coagulation, and fibrinolysis. Experimental data suggest that tissue plasminogen activator (tPA) regulates renal neutrophil influx in kidney ischemia and reperfusion injury. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183093
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http://dx.doi.org/10.1016/j.transproceed.2019.01.056DOI Listing
April 2019
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Increased Phosphatidylserine on Blood Cells in Oral Squamous Cell Carcinoma.

J Dent Res 2019 Apr 12:22034519843106. Epub 2019 Apr 12.

3 Department of Hematology, First Hospital, Harbin Medical University, Harbin, China.

The specific function of phosphatidylserine (PS) in the context of the development of a hypercoagulable state among individuals with oral squamous cell carcinoma (OSCC) is uncertain. The goal of this study was therefore to assess the exposure of PS on microparticles (MPs) as well as on endothelial and blood cells and to assess procoagulant activity (PCA) as a function of the stage of OSCC progression. We recruited patients with OSCC ( n = 63) as well as healthy controls ( n = 26) to participate in this study. Read More

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http://dx.doi.org/10.1177/0022034519843106DOI Listing
April 2019
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In Vitro Effects on Thrombin of Paris Saponins and In Vivo Hemostatic Activity Evaluation of var. .

Molecules 2019 Apr 11;24(7). Epub 2019 Apr 11.

West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

The resource shortage of Rhizoma Paridis has never been effectively addressed, and the industry continues to search for alternative resources. The in vitro effects on thrombin of Paris saponins and in vivo hemostatic activity of var. (PF) were evaluated in this study. Read More

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https://www.mdpi.com/1420-3049/24/7/1420
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http://dx.doi.org/10.3390/molecules24071420DOI Listing
April 2019
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Blood coagulation dynamic testing sensor based on electromagnetic vibration.

Proc Inst Mech Eng H 2019 Apr 12:954411919837308. Epub 2019 Apr 12.

1 Changchun University of Science and Technology, Changchun, China.

Rapid detection techniques and methods of blood coagulation have attracted wide attention in academia and the business community in the presence of the increased demands for rapid assessment (point-of-care testing) of patients from surgery, intensive care unit, and other departments. The differential equation of vibration system composed of elastic support and electromagnetic induction devices was set up using the principle of damping vibration and establishing the dynamics model; meanwhile, the harmonic response analysis and vibration fatigue coupling analysis were carried out, the analysis results were optimized, and the experimental device of the electromagnetic induction testing sensor was established. In addition, the experimental device with blood coagulation reagent was assorted to establish the standard point-of-care testing rapid blood coagulation detection curve, and to compare the testing curve with that of the imported point-of-care testing blood coagulation instrument. Read More

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http://dx.doi.org/10.1177/0954411919837308DOI Listing

Novel Cellulose - Halloysite Hemostatic Nanocomposite Fibers with a Dramatic Reduction in Human Plasma Coagulation Time.

ACS Appl Mater Interfaces 2019 Apr 12. Epub 2019 Apr 12.

High performance cellulose - halloysite hemostatic nanocomposite fibers (CHNFs) are fabricated using a one-step wet-wet electrospinning process and evaluated for human plasma coagulation by activated partial thromboplastin time. These novel biocompatible CHNFs exhibit 2.4-times faster plasma coagulation time compared with the industry gold standard Quikclot Combat Gauze® (QCG®). Read More

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http://dx.doi.org/10.1021/acsami.9b04615DOI Listing

Wearable artificial kidney and wearable ultrafiltration device vascular access-future directions.

Clin Kidney J 2019 Apr 19;12(2):300-307. Epub 2018 Sep 19.

International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy.

Background: Since 2005, three human clinical trials have been performed with the Wearable Artificial Kidney (WAK) and Wearable Ultrafiltration (WUF) device. The lack of an adequate vascular access (VA) has been pointed out as the main limitation to their implementation. Based on the current level of understanding, we will make the first conceptual proposal of an adequate VA suitable for the WAK and the WUF. Read More

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http://dx.doi.org/10.1093/ckj/sfy086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452182PMC

Investigation of Frequency of the Lethal Triad and Its 24 Hours Prognostic Value among Patients with Multiple Traumas.

Open Access Maced J Med Sci 2019 Mar 26;7(6):962-966. Epub 2019 Mar 26.

Department of Emergency Medicine, Orthopedic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Death in multiple trauma (MT) patients is one of the serious concerns of the medical service provider. Any prediction of the likelihood of death on the assessment of the patient's condition is performed using different variables, one of the tools in the triage of patients to determine their condition.

Aim: We aimed to investigate the frequency and the predictive value of death in 24 hours triad of death in patients qualified with multiple traumas admitted to Imam Khomeini hospital. Read More

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http://dx.doi.org/10.3889/oamjms.2019.217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454176PMC
March 2019
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The Association between the Level of Antithrombin III and Mortality in Children with Sepsis.

Open Access Maced J Med Sci 2019 Mar 26;7(6):959-961. Epub 2019 Mar 26.

Department of Child Health, Medical School, University of Sumatera Utara, Medan, Indonesia.

Background: Sepsis is a significant cause of morbidity and mortality in children. The diagnosis of sepsis remains continuing to develop which determines treatment and prognostic. Antithrombin III is one of the coagulation markers to evaluate the prognosis of sepsis. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2019.211
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http://dx.doi.org/10.3889/oamjms.2019.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454173PMC
March 2019
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Incidence and features of thrombosis in children with inherited antithrombin deficiency.

Haematologica 2019 Apr 11. Epub 2019 Apr 11.

Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain;

Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). Read More

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http://dx.doi.org/10.3324/haematol.2018.210666DOI Listing
April 2019
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Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway.

Part Fibre Toxicol 2019 Apr 11;16(1):16. Epub 2019 Apr 11.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China.

Background: Safety evaluation is a prerequisite for nanomaterials in a wide range of fields, including chemical industries, medicine or food sciences. Previously, we had demonstrated that SiNPs could trigger the thrombotic effects in vivo, but the underlying mechanisms remain unknown. This study was aimed to explore and verify the role of miR-451a on SiNPs-induced vascular endothelial dysfunction and pre-thrombotic state. Read More

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http://dx.doi.org/10.1186/s12989-019-0300-xDOI Listing