120,086 results match your criteria Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis[Journal]


Validation of an MPC Polymer Coating to Attenuate Surface-Induced Crosstalk between the Complement and Coagulation Systems in Whole Blood in In Vitro and In Vivo Models.

Macromol Biosci 2019 Feb 20:e1800485. Epub 2019 Feb 20.

Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden.

Artificial surfaces that come into contact with blood induce an immediate activation of the cascade systems of the blood, leading to a thrombotic and/or inflammatory response that can eventually cause damage to the biomaterial or the patient, or to both. Heparin coating has been used to improve hemocompatibility, and another approach is 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer coatings. Here, the aim is to evaluate the hemocompatibility of MPC polymer coating by studying the interactions with coagulation and complement systems using human blood in vitro model and pig in vivo model. Read More

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http://dx.doi.org/10.1002/mabi.201800485DOI Listing
February 2019

Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F.

Elife 2019 Feb 20;8. Epub 2019 Feb 20.

Department of Structural Biology, University of Groningen, Groningen, Netherlands.

The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of phosphatidylserine in platelets. The protein is part of a family of membrane proteins, which encompasses calcium-activated channels for ions and lipids. Here, we reveal features of murine TMEM16F (mTMEM16F) that underlie its function as a lipid scramblase and an ion channel. Read More

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http://dx.doi.org/10.7554/eLife.44365DOI Listing
February 2019

Platelets retain inducible alpha granule secretion by P-selectin expression but exhibit mechanical dysfunction during trauma-induced coagulopathy.

J Thromb Haemost 2019 Feb 19. Epub 2019 Feb 19.

Department of Emergency Medicine, University of Washington, Seattle, WA.

Background: Trauma-induced coagulopathy (TIC) is a common and deadly bleeding disorder. Platelet dysfunction is present during TIC, but its mechanisms remain unclear. Platelets are currently thought to become "exhausted", a state in which they have released their granule contents and can no longer aggregate or contract. Read More

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http://dx.doi.org/10.1111/jth.14414DOI Listing
February 2019

Intraoperative and postoperative effects of TEG-guided platelet transfusion on antiplatelet drug-related intracerebral hemorrhage patients.

Exp Ther Med 2019 Mar 14;17(3):2263-2267. Epub 2019 Jan 14.

Department of Blood Transfusion, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, P.R. China.

Intraoperative and postoperative effects of platelet transfusion on antiplatelet drug-related intracerebral hemorrhage (ICH) patients were investigated. A retrospective study on 82 ICH patients undergoing emergency surgical treatment caused by antiplatelet drugs was conducted. Among them, 51 patients treated with platelet transfusion served as the observation group and 31 patients without platelet transfusion as the control group. Read More

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http://dx.doi.org/10.3892/etm.2019.7169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364191PMC

Assessment of serum biomarkers and coagulation/fibrinolysis markers for prediction of neurological outcomes of out of cardiac arrest patients treated with therapeutic hypothermia.

Clin Exp Emerg Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Emergency Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.

Objective: Despite increased survival in patients with cardiac arrest, it remains difficult to determine patient prognosis at the early stage. This study evaluated the prognosis of cardiac arrest patients using brain injury, inflammation, cardiovascular ischemic events, and coagulation/fibrinolysis markers collected 24, 48, and 72 hours after return of spontaneous circulation (ROSC).

Methods: From January 2011 to December 2016, we retrospectively observed patients who underwent therapeutic hypothermia. Read More

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http://dx.doi.org/10.15441/ceem.17.273DOI Listing
February 2019

The Haemostatic Mechanism and Menstruation: The Role of Intra-Uterine Contraceptive Devices.

Thromb Haemost 1979 Jul 18;42(1):1548-1556. Epub 2019 Feb 18.

The Regional Blood Transfusion Centre, Leeds, University Departments of Pathology and Obstetrics & Gynaecology and the Department of Medicine, Leeds General Infirmary, Leeds, U.K.

The haemostatic mechanism of 40 female patients undergoing menstruation, 20 with intra-uterine devices (IUCD) and 20 without (Control), were studied. The patients' coagulation profiles, fibrinolytic system and platelet functions were studied before and after hysterectomy. Platelet survival times and platelet consumption was determined using Cr. Read More

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http://dx.doi.org/10.1055/s-0038-1657057DOI Listing

Effects of Splenectomy on Blood Coagulation and Fibrinolysis in Patients with Liver Cirrhosis: Possible Role of the Spleen in Haemostasis.

Thromb Haemost 1979 Jul 18;42(1):1529-1535. Epub 2019 Feb 18.

The 2nd Department of Surgery and Department of Central Clinical Laboratory, Tokyo University School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan.

Blood coagulation and fibrinolysis before and after splenectomy was studied in 74 cases of liver cirrhosis. A hypocoagulable state was found before splenectomy, but the platelet count, and the levels of fibrinogen, plasminogen, ±-macroglobulin and antithrombin III increased significantly after splenectomy (p < 0.05 to p < 0. Read More

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http://dx.doi.org/10.1055/s-0038-1657055DOI Listing

Activation of TF-Dependent Blood Coagulation Pathway and VEGF-A in Patients with Essential Thrombocythemia.

Medicina (Kaunas) 2019 Feb 16;55(2). Epub 2019 Feb 16.

Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, Poland.

Recent studies suggest that a vascular endothelial growth factor (VEGF-A) may be involved in the thrombotic process by stimulating the expression of tissue factor in vascular endothelial cells. Tissue factor (TF) can also stimulate the transcription of the gene encoding VEGF-A. The relationship between coagulation and angiogenesis in myeloproliferative neoplasms is not fully understood. Read More

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http://dx.doi.org/10.3390/medicina55020054DOI Listing
February 2019

Vascular tissue engineering: Fabrication and characterization of acetylsalicylic acid-loaded electrospun scaffolds coated with amniotic membrane lysate.

J Cell Physiol 2019 Feb 18. Epub 2019 Feb 18.

Department of Molecular biology and genetic engineering and Department of nanotechnology and tissue engineering, Stem Cell Technology Research Center, Tehran, Iran.

As the incidence of small-diameter vascular graft (SDVG) occlusion is considerably high, a great amount of research is focused on constructing a more biocompatible graft. The absence of a biocompatible surface in the lumen of the engineered grafts that can support confluent lining with endothelial cells (ECs) can cause thrombosis and graft failure. Blood clot formation is mainly because of the lack of an integrated endothelium. Read More

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http://dx.doi.org/10.1002/jcp.28266DOI Listing
February 2019

Attenuating the abnormally high expression of AEBP1 suppresses the pathogenesis of childhood acute lymphoblastic leukemia via p53-dependent signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1184-1195

Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: This study aimed to explore the candidate genes and their potential mechanism in childhood acute lymphoblastic leukemia (cALL).

Materials And Methods: Differentially expressed genes (DEGs) were screened from GSE67684 (treatment), GSE28460 (relapse), and GSE60926 (relapse). The expression of AEBP1 at different stages of cALL was analyzed followed by functional enrichment analysis of its co-expressed genes. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17011DOI Listing
February 2019

Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis.

Front Immunol 2019 4;10:85. Epub 2019 Feb 4.

Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria.

The transcription factor NF-κB is a central mediator of inflammation with multiple links to thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types within the vasculature and the circulation that are involved in thrombo-inflammatory processes. All these cells express NF-κB, which mediates important functions in cellular interactions, cell survival and differentiation, as well as expression of cytokines, chemokines, and coagulation factors. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00085
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http://dx.doi.org/10.3389/fimmu.2019.00085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369217PMC
February 2019
1 Read

Anti-adhesive effects of human soluble thrombomodulin and its domains.

Biochem Biophys Res Commun 2019 Feb 15. Epub 2019 Feb 15.

Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu-city, Mie, 514-8507, Japan.

We reported previously that leukocyte β2 integrins (LFA-1 and Mac-1) bind to the serine/threonine-rich domain of thrombomodulin (TM) expressed on vascular endothelial cells (VECs). Recombinant human soluble TM (rhsTM, TMD123) has been approved as a therapeutic drug for septic disseminated intravascular coagulation. However, the roles of TMD123 on the adhesion of leukocyte integrins to VECs remain unclear. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.041DOI Listing
February 2019

Why does a point of care guided transfusion algorithm not improve blood loss and transfusion practice in patients undergoing high-risk cardiac surgery? A prospective randomized controlled pilot study.

BMC Anesthesiol 2019 Feb 18;19(1):24. Epub 2019 Feb 18.

Department of Anaesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany.

Background: Adult cardiac surgery is often complicated by elevated blood losses that account for elevated transfusion requirements. Perioperative bleeding and transfusion of blood products are major risk factors for morbidity and mortality. Timely diagnostic and goal-directed therapies aim at the reduction of bleeding and need for allogeneic transfusions. Read More

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http://dx.doi.org/10.1186/s12871-019-0689-7DOI Listing
February 2019

Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock.

Thromb Res 2019 Feb 12;176:39-45. Epub 2019 Feb 12.

Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; University of Queensland, Brisbane, Australia. Electronic address:

Introduction: Fluid resuscitation is a cornerstone of severe sepsis management, however there are many uncertainties surrounding the type and volume of fluid that is administered. The entire spectrum of coagulopathies can be seen in sepsis, from asymptomatic aberrations to fulminant disseminated intravascular coagulation (DIC). The aim of this study was to determine if fluid resuscitation with saline contributes to the haemostatic derangements in an ovine model of endotoxemic shock. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.02.015DOI Listing
February 2019

Factor XIII topology: organization of B subunits and changes with activation studied with single-molecule atomic force microscopy.

J Thromb Haemost 2019 Feb 17. Epub 2019 Feb 17.

Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Background: Factor XIII (FXIII) is a precursor of the blood plasma transglutaminase (FXIIIa) that is generated by thrombin and Ca and covalently cross-links fibrin to strengthen blood clots. Inactive plasma FXIII is a heterotetramer with two catalytic A subunits and two non-catalytic B subunits. Inactive A subunits have been characterized crystallographically, while the atomic structure of the entire FXIII and B subunits is unknown and the oligomerization state of activated A subunits remains controversial. Read More

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http://dx.doi.org/10.1111/jth.14412DOI Listing
February 2019
2 Reads

Characteristics Associated With Mortality in 372 Patients Receiving Low-Dose Recombinant Factor VIIa (rFVIIa) for Cardiac Surgical Bleeding.

J Cardiothorac Vasc Anesth 2019 Jan 22. Epub 2019 Jan 22.

Department of Anesthesiology, Division of Critical Care, Kansas University Medical Center, Kansas City, KS. Electronic address:

Objective: Activated recombinant factor VII (rFVIIa) has been used to treat cardiac surgical bleeding in an off-label manner. This observational report analyzes the outcomes with use of a low dose and early administration of rFVIIa for cardiac surgical bleeding.

Design: A retrospective, observational study. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.047DOI Listing
January 2019
1 Read

Increased galactose expression and enhanced clearance in patients with Low von Willebrand factor.

Blood 2019 Feb 15. Epub 2019 Feb 15.

Haemostasis Research Group, Department of Molecular and Cellular Therapeutics, Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, Dublin, Ireland.

Glycan determinants on von Willebrand factor (VWF) play critical roles in regulating its susceptibility to proteolysis and clearance. Abnormal glycosylation has been shown to cause VWD in a number of different mouse models. However, due to the significant technical challenges associated with accurate assessment of VWF glycan composition, the importance of carbohydrates in human VWD pathogenesis remains largely unexplored. Read More

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http://dx.doi.org/10.1182/blood-2018-09-874636DOI Listing
February 2019

HIV and Cardiovascular Diseases Risk: Exploring the Interplay between T cell Activation, Coagulation, Monocyte Subsets and Lipid Subclass Alterations.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, South Africa.

Although rollout of combined anti-retroviral treatment (cART) has blunted human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) onset, there is increased development of cardiovascular diseases (CVD) in HIV-infected individuals. While most HIV-infected individuals on cART achieve viral suppression, this may not necessarily result in complete immunological recovery. This study therefore evaluated T cell-mediated changes and coagulation markers in HIV-positive individuals to ascertain their potential to increase CVD risk. Read More

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http://dx.doi.org/10.1152/ajpheart.00797.2018DOI Listing
February 2019

Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients.

Theor Biol Med Model 2019 Feb 14;16(1). Epub 2019 Feb 14.

Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.

Background: Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and bleeding complications such as disseminated intravascular coagulation (DIC). However, the mechanisms underlying this improvement have yet to be elucidated. In vitro studies have reported that RA upregulates thrombomodulin (TM) expression on the endothelial cell surface. Read More

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http://dx.doi.org/10.1186/s12976-019-0099-zDOI Listing
February 2019

The hemostasis system in children with hereditary spherocytosis.

Thromb Res 2019 Feb 5;176:11-17. Epub 2019 Feb 5.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia.

Introduction: Patients with hereditary spherocytosis (HS) are characterized by having an increased risk for thrombosis. An early manifestation of thrombotic complications can occur even in childhood, especially after surgery. Hypercoagulability can be associated with hemolytic crises. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.02.004DOI Listing
February 2019
1 Read

Accuracy assessment of consecutive test strip lots for whole blood INR point-of-care instruments: clarifying the role of frozen plasma pools.

Clin Chem Lab Med 2019 Feb 14. Epub 2019 Feb 14.

Coagulation Reference Laboratory, Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Background In the Netherlands, each new lot of test strips for the CoaguChek XS is validated by a group of collaborating centers. The purpose of this study was to assess the accuracy of the international normalized ratio (INR) measured with consecutive test strip lots and the suitability of frozen plasma pools for accuracy evaluation. Methods Each year, a particular lot of CoaguChek XS test strips is used as reference lot. Read More

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http://dx.doi.org/10.1515/cclm-2018-1054DOI Listing
February 2019

Coagulation Changes induced by Lower Body Negative Pressure in Men and Women.

J Appl Physiol (1985) 2019 Feb 14. Epub 2019 Feb 14.

Physiology, Medical University of Graz, Austria.

We investigated whether lower body negative pressure (LBNP) application leads to coagulation activation in whole blood (WB) samples in healthy men and women. Twenty-four women and twenty-one men, all healthy young participants, with no histories of thrombotic disorders and not on medications, were included. LBNP was commenced at -10 mmHg and increased by -10 mmHg every-five minutes until a maximum of -40 mmHg. Read More

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https://www.physiology.org/doi/10.1152/japplphysiol.00940.20
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http://dx.doi.org/10.1152/japplphysiol.00940.2018DOI Listing
February 2019
1 Read

Coagulation factor XIII-A and activated XIII-A decrease in some deep vein thrombosis patients following catheter-directed thrombolysis.

Blood Coagul Fibrinolysis 2019 Feb 11. Epub 2019 Feb 11.

Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, University of British Columbia.

: To assess the effect of tissue plasminogen activator administered during catheter-directed thrombolysis (CDT) on coagulation factor XIII (FXIII). Thrombolytic therapy carries significant risks, such as life-threatening bleeds. The mechanisms responsible for major bleeds and intracerebral hemorrhages during thrombolysis are not fully understood. Read More

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http://dx.doi.org/10.1097/MBC.0000000000000797DOI Listing
February 2019
1 Read

Clinical standards for patient blood management and perioperative hemostasis and coagulation management position paper of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI).

Minerva Anestesiol 2019 Feb 13. Epub 2019 Feb 13.

S.C. di Anestesia e Rianimazione, Dipartimento di Scienze Mediche e Chirurgiche, Università di Foggia, Foggia, Italy -

Patient blood management is currently defined as the application of evidence based medical and surgical concepts designed to maintain hemoglobin (Hb), optimize hemostasis and minimize blood loss to improve patient outcome. Blood management focus on the perioperative management of patients undergoing surgery or other invasive procedures in which significant blood loss occurs or is expected. Preventive strategies are emphasized to identify and manage anemia, reduce iatrogenic blood losses, optimize hemostasis (e. Read More

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http://dx.doi.org/10.23736/S0375-9393.19.12151-7DOI Listing
February 2019
1 Read

Optimised methods (SDS/PAGE and LC-MS) reveal deamidation in all examined transglutaminase-mediated reactions.

FEBS Open Bio 2019 Feb 18;9(2):396-404. Epub 2019 Jan 18.

Research Department Covalab S.A.S Lyon France.

Transglutaminases (TGs) are a family of structurally and functionally related enzymes that catalyse calcium-dependent post-translational modifications of proteins through protein-protein crosslinking, amine incorporation, or deamidation. For many years deamidation mediated by TGs was considered to be a side reaction, but recently substrate-specific deamidations have been reported. Here we describe an optimised SDS/PAGE assay for the easy and rapid monitoring of the TG reaction with small peptides. Read More

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http://dx.doi.org/10.1002/2211-5463.12575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356169PMC
February 2019

Clinical Features and Outcomes of Peripheral Vascular Disease Patients Receiving Red Blood Cell Transfusions.

Cureus 2018 Dec 4;10(12):e3682. Epub 2018 Dec 4.

Emergency Medicine, Charleston Area Medical Center, Charleston, USA.

Background Peripheral vascular disease (PVD) patients are commonly transfused with red blood cells (RBC) due to their inability to compensate for anemia and blood loss. Anemias, as well as allogeneic transfusions, have been demonstrated as independent risk factors for increased mortality and morbidity following cardiovascular procedures. The relationships between anemia, transfusion, and adverse outcomes in PVD patients remain unascertained and understudied. Read More

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http://dx.doi.org/10.7759/cureus.3682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367124PMC
December 2018

Brain Endothelium: The "Innate Immunity Response Hypothesis" in Cerebral Malaria Pathogenesis.

Front Immunol 2018 29;9:3100. Epub 2019 Jan 29.

Instituto Gulbenkian de Ciência, Oeiras, Portugal.

Cerebral malaria (CM) is a life-threatening neurological syndrome caused by infection afflicting mainly children in Africa. Current pathogenesis models implicate parasite and host-derived factors in impairing brain vascular endothelium (BVE) integrity. Sequestration of -infected red blood cells (iRBCs) in brain microvessels is a hallmark of CM pathology. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03100
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http://dx.doi.org/10.3389/fimmu.2018.03100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361776PMC
January 2019
1 Read

[Severe coagulation abnormality during treatment for ischemic enteritis in an older patient taking a direct oral anticoagulant].

Nihon Ronen Igakkai Zasshi 2019 ;56(1):74-78

Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center.

An 85-year-old woman hospitalized for rehabilitation after cerebral infarction developed persistent bloody diarrhea and was transferred to our hospital (day 1). Contrast-enhanced computed tomography of the abdomen showed edematous thickening extending from the left side of the transverse colon to the rectum, with decreased mucosal enhancement. She was diagnosed with ischemic enteritis. Read More

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https://www.jstage.jst.go.jp/article/geriatrics/56/1/56_56.7
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http://dx.doi.org/10.3143/geriatrics.56.74DOI Listing
January 2019
2 Reads

Potential role of activated factor VIII (FVIIIa) in FVIIa/tissue factor-dependent FXa generation in initiation phase of blood coagulation.

Int J Hematol 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatrics, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan.

Factor VIIa/tissue factor (FVIIa/TF) initiates blood coagulation by promoting FXa generation (extrinsic-Xa). Subsequent generation of intrinsic FXa (intrinsic-Xa) amplifies thrombin formation. Previous studies suggested that FVIIa/TF activates FVIII rapidly in immediate coagulation reactions, and FVIIa/TF/FXa activates FVIII prior to thrombin-dependent feedback. Read More

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http://dx.doi.org/10.1007/s12185-019-02611-3DOI Listing
February 2019

Severe Acquired Coagulopathy During Fulminant Sepsis Most Likely Caused by Exotoxins (SSLs).

Eur J Case Rep Intern Med 2018 27;5(12):0001002. Epub 2018 Dec 27.

Internal Medicine, Vascular Medicine, Rijnstate Hospital Arnhem, The Netherlands.

Haemostatic abnormalities frequently occur during sepsis and are most often attributed to disseminated intravascular coagulation (DIC). We report the case of a patient with severe coagulopathy acquired during fulminant sepsis. DIC was not present. Read More

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http://dx.doi.org/10.12890/2018_0001002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346979PMC
December 2018
1 Read

Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries (TARGETS): study protocol for a prospective, randomized, double-blind, non-inferiority trial.

Trials 2019 Feb 12;20(1):125. Epub 2019 Feb 12.

Department of Anesthesiology, Peking Union Medical College Hospital, No.1 Shuai Fu Yuan, Wang Fu Jing Street, Beijing, 100730, People's Republic of China.

Background: Tranexamic acid (TXA) has been routinely delivered in multisegmental spinal decompression and bone graft fusion surgeries with satisfactory outcomes in minimizing gross blood loss and transfusion demands. However, concerns remain that intravenously delivered TXA (ivTXA) may increase risks of postoperative convulsive seizures and systemic thrombogenicity. Topical use of TXA (tTXA), being more targeted to the surgical bleeding site while minimizing patient systemic exposure to ivTXA, has been successfully applied to attenuate blood losses and transfusion requirements in hip and knee arthroplasty. Read More

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http://dx.doi.org/10.1186/s13063-019-3231-9DOI Listing
February 2019
2 Reads

A phase III study comparing secondary long-term prophylaxis versus on-demand treatment with vWF/FVIII concentrates in severe inherited von Willebrand disease.

Blood Transfus 2019 Feb 4:1-8. Epub 2019 Feb 4.

Division of Haematology and Transfusion Medicine, "Luigi Sacco" University Hospital, Milan, Italy.

Background: There is a lack of prospective clinical trials specifically designed to evaluate the benefits of prophylaxis with vWF/FVIII concentrates in patients with inherited von Willebrand disease (vWD). The aim of the study was to compare efficacy of secondary long-term prophylaxis (PRO) with vWF/FVIII in the prevention of bleeding episodes in severe vWD patients to standard of care (on-demand treatment; ODT).

Materials And Methods: In this 12-month, phase III, open-label study (PRO. Read More

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http://dx.doi.org/10.2450/2019.0183-18DOI Listing
February 2019
1 Read

Elevated D-dimer increases the risk of dialysis after surgery in patients with Stanford A aortic dissection through the impact of the coagulation system.

J Thorac Dis 2018 Dec;10(12):6783-6793

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background: To investigate whether Elevated D-dimer increases the risk of dialysis after surgery in patients with Stanford A aortic dissection.

Methods: A total of 120 patients with type A aortic dissection who underwent surgery at our institution from August 2014 to December 2015 were enrolled in the study. Acute type A aortic dissection was treated with Sun's operation. Read More

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http://jtd.amegroups.com/article/view/25902/19462
Publisher Site
http://dx.doi.org/10.21037/jtd.2018.11.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344706PMC
December 2018
3 Reads

Efficacy of Hematological and Coagulation Parameters in the Diagnosis and Prognosis of Patients with Acute Coronary Syndrome.

J Tehran Heart Cent 2018 Jul;13(3):115-125

Cardiology Department, Civil Hospital, Karachi, Pakistan.

The diagnosis and management of acute coronary syndrome (ACS) have improved significantly over the past few decades; however, the recognition of myocardial ischemia still proves to be a dilemma for cardiologists. The aim of this study was to determine the role of hematological and coagulation parameters in the diagnosis and prognosis of patients with ACS. This prospective study recruited 250 patients with ACS and 250 healthy controls. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368913PMC
July 2018
3 Reads

Correlation of early ROTEM parameters with conventional coagulation tests in patients with chronic liver disease undergoing liver transplant.

Indian J Anaesth 2019 Jan;63(1):21-25

Center for Liver and Biliary Sciences, Max Super Speciality Hospital, New Delhi, India.

Background And Aims: Viscoelastic tests such as rotational thromboelastometry (ROTEM) provide a quick and holistic assessment of coagulation status to guide transfusion during liver transplant (LT). Conventional coagulation tests (CCTs) measure single parameters in isolation, and also the results are delayed hampering management of patients during surgery. We evaluated the correlation of early ROTEM-derived parameters with CCTs and also assessed the ability of ROTEM-derived parameters to predict thrombocytopaenia and hypofibrinogenaemia during LT in patients with end-stage liver disease (ESLD). Read More

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http://dx.doi.org/10.4103/ija.IJA_334_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341893PMC
January 2019

A comparison of low and standard anti-coagulation regimens in extracorporeal membrane oxygenation.

J Heart Lung Transplant 2019 Jan 31. Epub 2019 Jan 31.

Department of Surgery, George Washington University Medical Center, Washington, DC.

Background: Bleeding and need for blood products are major complications associated with extracorporeal membrane oxygenation (ECMO) use. This study evaluated bleeding complications with low and standard heparinization protocols in the maintenance of venoarterial (VA)-ECMO.

Methods: A retrospective comparison was performed of 2 methods of heparinization in a contemporaneous series of adult patients supported with VA-ECMO at Rush University Medical Center, between November 2011 and November 2016. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1313DOI Listing
January 2019

Assessment of Mulberry leaf as a potential feed supplement for animal feeding in P.R. China.

Asian-Australas J Anim Sci 2019 Jan 4. Epub 2019 Jan 4.

Yunnan Academy of Grassland and Animal Science, Kunming 650212, Yunnan, China.

Objective: Mulberry (Morus alba L.) is a cultivated shrub grown widely in the sub-tropical and tropical areas. It has been shown that mulberry leaf contains high levels of protein while having polyphenols as phytonutrients. Read More

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http://dx.doi.org/10.5713/ajas.18.0671DOI Listing
January 2019
0.541 Impact Factor

Nanoparticles in the lungs of old mice: Pulmonary inflammation and oxidative stress without procoagulant effects.

Sci Total Environ 2018 Dec 11;644:907-915. Epub 2018 Jul 11.

Department of Public Health and Primary Care, Occupational and Environmental Toxicology, KU Leuven, Leuven, Belgium. Electronic address:

Pulmonary exposure to nanoparticles (NPs) has been shown to induce pulmonary as well as cardiovascular toxicity. These effects might be enhanced in elderly subjects as a result of a compromised immunity and/or declined organ functions. To study the adverse in vivo effects of NPs in a model for the elderly, we exposed 18-month-old C75Bl/6 mice to multi-walled carbon nanotubes (MWCNTs) or ZnO NPs by intratracheal instillation once a week during 5 consecutive weeks. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.06.301DOI Listing
December 2018
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Platelet count abnormalities and peri-operative outcomes in adults undergoing elective, non-cardiac surgery.

PLoS One 2019 11;14(2):e0212191. Epub 2019 Feb 11.

Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, United States of America.

Background: Anemia and transfusion of blood in the peri-operative period have been shown to be associated with increased morbidity and mortality across a wide variety of non-cardiac surgeries. While tests of coagulation, including the platelet count, have frequently been used to identify patients with an increased risk of peri-operative bleeding, results have been equivocal. The aim of this study was to assess the effect of platelet level on outcomes in patients undergoing elective surgery. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212191PLOS
February 2019

[A comparative analysis of laparoscopic and retroperitoneoscopic partial nephrectomy depending on the type of temporary and definite hemostasis].

Urologiia 2018 Dec(6):95-100

FGAOU VO of I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia, Moscow, Russia.

Aim: to carry out a comparative analysis of treatment results of patients with renal tumors who were undergone to nephron-sparing surgery, depending on the type of temporary and definite hemostasis.

Materials And Methods: a total of 163 laparoscopic partial nephrectomies were performed by single surgeon from January 2015 to July 2018. The comparative analysis of treatment results of patients with renal tumors based on following parameters: tumor stage, features of the tumor site, the duration of surgery, the amount of blood loss, complications rate and grade as well as functional and oncological outcomes, depending on the type of temporary and definite hemostasis, was conducted. Read More

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December 2018
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Thromboelastography On-the-Go: Evaluation of the TEG 6s Device During Ground and High-Altitude Aeromedical Evacuation with Extracorporeal Life Support.

J Trauma Acute Care Surg 2019 Feb 7. Epub 2019 Feb 7.

The Geneva Foundation, Tacoma, WA.

Background: Coagulation monitoring capabilities during transport are limited. Thromboelastography (TEG) is a whole-blood clotting test measuring clot formation, stabilization and fibrinolysis; and is traditionally performed in a laboratory. We evaluated a new point-of-care TEG analyzer, TEG 6s (Haemonetics; Braintree, MA), in a large animal model of combat-relevant trauma managed with extracorporeal life support (ECLS) during ground and high-altitude aeromedical evacuation. Read More

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http://dx.doi.org/10.1097/TA.0000000000002224DOI Listing
February 2019
1.970 Impact Factor

Hemostatic properties of cold-stored whole blood leukoreduced using a platelet-sparing versus a non-platelet-sparing filter.

Transfusion 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Whole blood (WB) is an appealing alternative to component-based transfusion in patients with significant bleeding. Historically, WB was transfused less than 48 hours after collection and was not leukoreduced (LR). However, LR components are now standard in many hospitals and LR WB is desirable. Read More

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http://dx.doi.org/10.1111/trf.15159DOI Listing
February 2019
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Anaphylactoid Syndrome of Pregnancy.

Nurs Womens Health 2019 Feb;23(1):38-48

Anaphylactoid syndrome of pregnancy (ASP) is a widespread, proinflammatory, anaphylactic-like reaction that can occur when amniotic fluid enters the maternal blood circulation. ASP is characterized by four cardinal findings: respiratory distress, altered mental status, hypotension, and disseminated intravascular coagulation. ASP is commonly associated with maternal and neonatal mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17514851183023
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http://dx.doi.org/10.1016/j.nwh.2018.11.006DOI Listing
February 2019
6 Reads

Injectable chitosan-nano bioglass composite hemostatic hydrogel for effective bleeding control.

Int J Biol Macromol 2019 Feb 6. Epub 2019 Feb 6.

Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi 682041, India. Electronic address:

Effective bleeding control is a major concern in trauma and major surgeries. Chitosan (Ch) as hemostatic agent has been widely used and when applied at the site of injury it acts by aggregating blood cells and forming a plug. Our prime interest is to enhance the blood clotting potential of Ch hydrogel. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.220DOI Listing
February 2019

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.

Neuron 2019 Jan 23. Epub 2019 Jan 23.

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

Cerebrovascular alterations are a key feature of Alzheimer's disease (AD) pathogenesis. However, whether vascular damage contributes to synaptic dysfunction and how it synergizes with amyloid pathology to cause neuroinflammation and cognitive decline remain poorly understood. Here, we show that the blood protein fibrinogen induces spine elimination and promotes cognitive deficits mediated by CD11b-CD18 microglia activation. Read More

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http://dx.doi.org/10.1016/j.neuron.2019.01.014DOI Listing
January 2019
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Effects of Caloric Restriction with Protein Supplementation on Plasma Protein Profiles in Middle-Aged Women with Metabolic Syndrome-A Preliminary Open Study.

J Clin Med 2019 Feb 6;8(2). Epub 2019 Feb 6.

School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan.

Background: Clinical studies have demonstrated that higher protein intake based on caloric restriction (CR) alleviates metabolic abnormalities. However, no study has examined the effects of plasma protein profiles on caloric restriction with protein supplementation (CRPS) in metabolic syndrome (MetS). Therefore, using a proteomic perspective, this pilot study investigated whether CRPS ameliorated metabolic abnormalities associated with MetS in middle-aged women. Read More

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http://dx.doi.org/10.3390/jcm8020195DOI Listing
February 2019
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[Comparative characteristics of the hemostatic potential in cord blood and in blood from premature and full-term newborns after birth according to the thromboelastography.]

Klin Lab Diagn 2018 ;63(9):553-556

Ivanovo research Institute of Maternity and Childhood. V.N. Gorodkova, Ivanovo, Russia.

The comparative characteristic of indicators of thromboelastography of umbilical cord blood and venous blood for 1-3 days of life at full-term and premature newborns is carried out. The study included 40 full term and 68 preterm infants at 1-5 days of life. Body weight of children was 3413. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-9-553-556DOI Listing
January 2018

Quantitative analysis of desmopressin (DDAVP) response in adult patients with type 1 von Willebrand disease.

Int J Lab Hematol 2019 Feb 8. Epub 2019 Feb 8.

Division of Hematology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.

Introduction: Patients with Type 1 von Willebrand disease (VWD) have reduced amounts of von Willebrand factor (VWF) in their blood. Desmopressin (DDAVP) has been used to raise the blood levels of VWF in these patients. However, not all patients with Type 1 VWD are known to respond to DDAVP therapy. Read More

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http://dx.doi.org/10.1111/ijlh.12978DOI Listing
February 2019
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Analysis of the effect of different doses of oral tranexamic acid on melasma: a multicentre prospective study.

Eur J Dermatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, Kinki University Faculty of Medicine, Higashiosaka, Japan.

Background: Melasma is pale brown to dark brown hyperpigmentation of the facial skin that commonly affects women of reproductive age. Treatment methods for melasma include oral and topical use of vitamin C, hydroquinone ointment, and laser treatment, with unsatisfactory results. Tranexamic acid (TA) has been shown to be effective against melasma, however, the optimal dose has not been investigated. Read More

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http://dx.doi.org/10.1684/ejd.2018.3494DOI Listing
February 2019
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Ex vivo haemostatic capacity of plasma upon thawing and beyond: a comparison between fresh frozen plasma (FFP) and frozen plasma prepared from whole blood stored at room temperature up to 24 hours postcollection (RTFP24).

Vox Sang 2019 Feb 7. Epub 2019 Feb 7.

Blood Services Group, Health Sciences Authority, Singapore, Singapore.

Background/objectives: We compared the ex vivo haemostatic capacity of RTFP24 with FFP upon thawing and >24 h post-thaw. We included thrombin generation (TG) as few studies had compared global haemostatic function, and most did not directly compare RTFP24 with FFP >24 h post-thaw.

Materials/methods: Twenty units each of RTFP24 and FFP were measured for coagulation factors and thrombin generation upon thawing (D0) and 4 days post-thaw (D4). Read More

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http://dx.doi.org/10.1111/vox.12749DOI Listing
February 2019