45,903 results match your criteria Blood Substitutes

Hemoglobin-based oxygen carriers camouflaged with membranes extracted from red blood cells: Optimization and assessment of functionality.

Mater Sci Eng C Mater Biol Appl 2022 Feb 3:112691. Epub 2022 Feb 3.

Department of Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Nils Koppels Allé, Building 423, 2800 Kgs. Lyngby, Denmark. Electronic address:

Despite being an indispensable clinical procedure, the transfusion of donor blood has important limitations including a short shelf-life, limited availability and specific storage requirements. Therefore, a lot of effort has been devoted to developing hemoglobin (Hb)-based oxygen carriers (HBOCs) that are able to replace or complement standard blood transfusions, especially in extreme life-threatening situations. Herein, we employed a Hb-loaded poly(lactide-co-glycolide) core which was subsequently coated with nanozymes to protect the encapsulated Hb from oxidation by reactive oxygen species. Read More

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February 2022

Environmentally relevant exposure to TBBPA and its analogues may not drastically affect human early cardiac development.

Environ Pollut 2022 May 13:119467. Epub 2022 May 13.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.

Tetrabromobisphenol A (TBBPA) and its substitutes and derivatives have been widely used as halogenated flame retardants (HFRs), in the past few decades. As a consequence, these compounds are frequently detected in the environment, as well as human bodily fluids, especially umbilical cord blood and breast milk. This has raised awareness of their potential risks to fetuses and infants. Read More

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Modeling the Effects of Disease, Drug Properties, and Material on Drug Transport From Intraocular Lenses.

Transl Vis Sci Technol 2022 May;11(5):14

Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada.

Purpose: Surgically implanted intraocular lenses (IOLs) may be used as drug-delivery devices, but their effectiveness is not well defined. Computational fluid dynamics models were developed to investigate the capability of IOLs to release drugs at therapeutic concentrations.

Methods: Models were generated using COMSOL Multiphysics. Read More

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Plasmid DNA Undergoes Two Compaction Regimes under Macromolecular Crowding.

ACS Macro Lett 2022 Feb 13;11(2):186-192. Epub 2022 Jan 13.

Biophysics and Soft Matter Laboratory, Department of Physics, Indian Institute of Technology, Kharagpur 721302, India.

The laser light scattering experiments were performed to explore the role of dextran (size (): 2.6, 6.9, and 17. Read More

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February 2022

Responses of promyelocytic leukemia HL60 cells as an inflammatory cell lineage model to silica microparticles used to coat blood collection tubes.

Int J Implant Dent 2022 May 14;8(1):24. Epub 2022 May 14.

Division of Oral Bioengineering, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan.

Background: The preparation of platelet-rich fibrin (PRF) requires glass blood collection tubes, and thus, the shortage or unavailability of such tubes has driven clinicians to search for suitable substitutes, such as silica-coated plastic tubes. However, we have previously demonstrated the cytotoxicity of silica microparticles (MPs) used in plastic tubes to cultured human periosteal cells. To further establish the effects of silica MPs on inflammation, we examined silica MP-induced changes in a human promyelocytic cell model in vitro. Read More

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Alpha-Linolenic Acid Modulates T Cell Incorporation in a 3D Tissue-Engineered Psoriatic Skin Model.

Cells 2022 Apr 30;11(9). Epub 2022 Apr 30.

Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, 1401 18e Rue, Québec City, QC G1J 2Z4, Canada.

Psoriasis is an autoimmune skin disease with an increased number of leukocytes infiltrating the dermal and epidermal compartments compared with normal skin. N-3 polyunsaturated fatty acids (n-3 PUFAs) are frequently used in the clinic in order to attenuate the symptoms of psoriasis. For psoriatic patients, a supplementation of the diet with alpha-linolenic acid (ALA) reduces the activation of T cell signaling pathways, leading to a significant reduction in inflammatory cytokine secretion. Read More

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Implication of genetic variants in primary microRNA processing sites in the risk of multiple sclerosis.

EBioMedicine 2022 May 10;80:104052. Epub 2022 May 10.

Department of Neurology, Division of Neuroimmunology, Rostock University Medical Center, Gehlsheimer Str. 20, Rostock 18147, Germany.

Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with a well-established genetic contribution to susceptibility. Over 200 genetic regions have been linked to the inherited risk of developing MS, but the disease-causing variants and their functional effects at the molecular level are still largely unresolved. We hypothesised that MS-associated single-nucleotide polymorphisms (SNPs) affect the recognition and enzymatic cleavage of primary microRNAs (pri-miRNAs). Read More

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Effect of water sorption on glass transition and microstructural variation of dextran & sugar mixtures.

Carbohydr Polym 2022 Aug 20;290:119505. Epub 2022 Apr 20.

State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China; China-Russia Agricultural Processing Joint Laboratory, Tianjin Agricultural University, Tianjin 300392, China. Electronic address:

Dextran is widely used as a model polysaccharide to study the interactions between polysaccharides and small molecule sugars. This study examined water sorption isotherms and glass transition temperatures (T) of mixtures of dextran with trehalose, lactose and sucrose for understanding how different disaccharides affect dextran's processing adaptation and storage performance relevant to water sorption. At the same chemical composition, monolayer water (m) was dextran & sucrose (dex&suc) > dextran & trehalose (dex&tre) > dextran & lactose (dex&lac). Read More

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Klotho functionalization on vascular graft for improved patency and endothelialization.

Mater Sci Eng C Mater Biol Appl 2022 Jan 3:112630. Epub 2022 Jan 3.

Department of Tissue Engineering, School of Intelligent Medicine, China Medical University, Shenyang 110122, China. Electronic address:

The Klotho (KL) gene is related to aging. In this study, SKL (secreted KL) and heparin were cross-linked to the acellular small intestinal submucosa (SIS). Based on this, tissue-engineered bioactive small blood vessels were constructed. Read More

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January 2022

Development of alginate-based hydrogels for blood vessel engineering.

Mater Sci Eng C Mater Biol Appl 2021 Dec 8:112588. Epub 2021 Dec 8.

3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal. Electronic address:

Vascular diseases are among the primary causes of death worldwide. In serious conditions, replacement of the damaged vessel is required. Autologous grafts are preferred, but their limited availability and difficulty of the harvesting procedures favour synthetic alternatives' use. Read More

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December 2021

In vitro effect of hydroxyethyl starch on coagulation in dogs as assessed by dynamic viscoelastic coagulometry.

Am J Vet Res 2022 May 11;83(6). Epub 2022 May 11.

Department of Statistics, Oklahoma State University, Stillwater, OK.

Objective: To evaluate the effect of 6% hydroxyethyl starch (HES) 670/0.75 and 6% HES 130/0.4 dilution of canine whole blood on coagulation using dynamic viscoelastic coagulometry (DVC). Read More

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In-depth analysis of iodine in artificial biofilm model layers by variable excitation energy XPS and argon gas cluster ion sputtering XPS.

Biointerphases 2022 May 4;17(3):031002. Epub 2022 May 4.

Bundesanstalt für Materialforschung und -prüfung, 12200 Berlin, Germany.

Here, we present a study on agarose thin-film samples that represent a model system for the exopolysaccharide matrix of biofilms. Povidone-iodide (PVP-I) was selected as an antibacterial agent to evaluate our x-ray photoelectron spectroscopy (XPS)-based methodology to trace specific marker elements, here iodine, commonly found in organic matrices of antibiotics. The in-depth distribution of iodine was determined by XPS analyses with variable excitation energies and in combination with argon gas cluster ion beam sputter cycles. Read More

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Influence of N-glycosylation in the A and C domains on the immunogenicity of factor VIII.

Blood Adv 2022 May 5. Epub 2022 May 5.

University of Washington, United States.

The most significant complication in hemophilia A treatment is the formation of inhibitors against factor VIII (FVIII) protein. Glycans and glycan-binding proteins are central to a properly functioning immune system. This study focuses on whether glycosylation of FVIII plays an important role in induction and regulation of anti-FVIII immune responses. Read More

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Bacitracin-Functionalized Dextran-MoSe with Peroxidase-like and Near-Infrared Photothermal Activities for Low-Temperature and Synergetic Antibacterial Applications.

ACS Appl Bio Mater 2022 May 2;5(5):2347-2354. Epub 2022 May 2.

School of Chemistry and Pharmaceutical Science, State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, P. R. China.

Bacitracin (an antimicrobial peptide, AMP)-modified dextran-MoSe nanosheets (AMP/dex-MoSe NSs) were constructed and applied for low-temperature and synergetic antibacterial applications. The near-infrared (NIR) photothermal and peroxidase-like activities of dex-MoSe were combined with the bacterial membrane-binding ability of AMP through electrostatic adsorption, and a multimode antibacterial method was realized. HO was converted into a hydroxyl radical (·OH) by AMP/dex-MoSe, which exhibits a higher antibacterial activity and can avoid the toxicity of a high concentration of HO. Read More

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Recent Biomimetic Approaches for Articular Cartilage Tissue Engineering and Their Clinical Applications: Narrative Review of the Literature.

Hamza Abu Owida

Adv Orthop 2022 22;2022:8670174. Epub 2022 Apr 22.

Medical Engineering Department, Faculty of Engineering, Al-Ahliyya Amman University, Amman 19328, Jordan.

Since articular cartilage is lacking blood vessels and nerves, its capacity to heal is extremely limited. This means that ruptured cartilage affects the joint as a whole. A health issue known as osteoarthritis can develop as a result of injury and deterioration. Read More

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Bioprinting and plastic compression of large pigmented and vascularized human dermo-epidermal skin substitutes by means of a new robotic platform.

J Tissue Eng 2022 Jan-Dec;13:20417314221088513. Epub 2022 Apr 25.

Tissue Biology Research Unit, Department of Pediatric Surgery, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.

Extensive availability of engineered autologous dermo-epidermal skin substitutes (DESS) with functional and structural properties of normal human skin represents a goal for the treatment of large skin defects such as severe burns. Recently, a clinical phase I trial with this type of DESS was successfully completed, which included patients own keratinocytes and fibroblasts. Yet, two important features of natural skin were missing: pigmentation and vascularization. Read More

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[Dynamics of sperm indicators in men with chronic prostatitis associated with secondary infertility based on the use of ANDROEXPERT SV1 suppositories].

Urologiia 2022 May(2):59-65

Federal Medical Research Centre of Fundamental and Translational Medicine, Novosibirsk, Russia.

Introduction: Chronic prostatitis (CP) is the most common cause of a disorder of not only sexual, but also reproductive functions in men, which is caused by a decrease in the quality of the ejaculate and is confirmed by a deterioration in spermogram parameters, up to oligoasthenoteratozoospermia and azoospermia. In such a situation, the onset of pregnancy in the natural cycle is impossible - even with a completely preserved reproductive function in a woman. As an active substance in the recovery of men with chronic prostatitis associated with secondary infertility, we proposed oxidised dextran in the form of a pharmaceutical composition, which was developed at Federal Research Centre for Fundamental and Translational Medicine, Novosibirsk, Russia; and produced by ANDROEXPERT Research and Manufacturing Company LTD, Novosibirsk, Russia. Read More

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Resistant starch-An accessible fiber ingredient acceptable to the Western palate.

Compr Rev Food Sci Food Saf 2022 Apr 27. Epub 2022 Apr 27.

School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.

Dietary fiber intakes in Western societies are concerningly low and do not reflect global recommended dietary fiber intakes for chronic disease prevention. Resistant starch (RS) is a fermentable dietary fiber that has attracted research interest. As an isolated ingredient, its fine particle size, relatively bland flavor, and white appearance may offer an appealing fiber source to the Western palate, accustomed to highly refined, processed grains. Read More

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Impacts of Gum Arabic and Polyvinylpyrrolidone (PVP) with Salicylic Acid on Peach Fruit () Shelf Life.

Molecules 2022 Apr 18;27(8). Epub 2022 Apr 18.

Nutrition and Food Science, Home Economics Department, Faculty of Specific Education, Mansura University, Mansoura 35516, Egypt.

Peaches are grown in many Egyptian orchards for local and global fresh market sales. The interior fruit tissue breakdown (IFTB), often resulting in decayed peaches, is a severe problem during marketing. Therefore, to minimize FTB of peaches, in this study, gum arabic (GA) and polyvinylpyrrolidone (PVP) were mixed with different concentrations of salicylic acid (SA) (0, 1, and 2 mM) and were applied as edible coating to extend the shelf life of peach fruits. Read More

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A Molecular Study of Aspirin and Tenofovir Using Gold/Dextran Nanocomposites and Surface-Enhanced Raman Spectroscopy.

Molecules 2022 Apr 15;27(8). Epub 2022 Apr 15.

National Laser Centre, Council for Scientific and Industrial Research, P.O. Box 395, Pretoria 0001, South Africa.

In this study, we show how surface enhanced Raman spectroscopy (SERS) can be used to monitor the molecular behaviour of aspirin and tenofovir as a means of screening medication for quality control purposes. Gold-coated slides combined with gold/dextran nanoaggregates were used to provide signal enhancement of the drugs using SERS. Aspirin (10% /) and tenofovir (20% /) were analysed in the presence of the nanomaterials to determine trends in molecular response to changes in gold/dextran concentrations. Read More

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Conductive Supramolecular Polymer Nanocomposites with Tunable Properties to Manipulate Cell Growth and Functions.

Int J Mol Sci 2022 Apr 14;23(8). Epub 2022 Apr 14.

Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.

Synthetic bioactive nanocomposites show great promise in biomedicine for use in tissue growth, wound healing and the potential for bioengineered skin substitutes. Hydrogen-bonded supramolecular polymers (3A-PCL) can be combined with graphite crystals to form graphite/3A-PCL composites with tunable physical properties. When used as a bioactive substrate for cell culture, graphite/3A-PCL composites have an extremely low cytotoxic activity on normal cells and a high structural stability in a medium with red blood cells. Read More

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Continuous Percoll Gradient Centrifugation of Erythrocytes-Explanation of Cellular Bands and Compromised Age Separation.

Cells 2022 Apr 11;11(8). Epub 2022 Apr 11.

Dynamics of Fluids, Experimental Physics, Saarland University, 66123 Saarbrücken, Germany.

(1) Background: When red blood cells are centrifuged in a continuous Percoll-based density gradient, they form discrete bands. While this is a popular approach for red blood cell age separation, the mechanisms involved in banding were unknown. (2) Methods: Percoll centrifugations of red blood cells were performed under various experimental conditions and the resulting distributions analyzed. Read More

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Internal exposure of Flemish teenagers to environmental pollutants: Results of the Flemish Environment and Health Study 2016-2020 (FLEHS IV).

Int J Hyg Environ Health 2022 May 19;242:113972. Epub 2022 Apr 19.

BioStat, Data Science Institute, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.

The Flemish Environment and Health Study (FLEHS) collects information on internal exposure to a broad range of environmental chemicals in the general population in Flanders, the Northern region of Belgium. The aim is to establish biomonitoring exposure distributions for the general population in support of public health and environmental policy, environmental risk assessment and risk management decisions. In 2017-2018, urine and blood samples were collected from 428 teenagers by a stratified clustered two stage randomized design. Read More

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Spatiotemporal Control of Melanin Synthesis in Liquid Droplets.

ACS Appl Mater Interfaces 2022 May 22;14(18):20520-20527. Epub 2022 Apr 22.

Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

Melanins are natural biopolymers that have remarkable properties including UV-protection, coloration, and antioxidant activity. Their biosynthesis is regulated both spatially and temporally and involves supramolecular templating and compartmentalization of enzymes and reactants within specialized organelles called melanosomes. In contrast, the laboratory-based bulk synthesis of melanin by tyrosine or dopamine oxidation is a poorly controlled process, resulting in materials with undefined properties. Read More

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In situ injectable nano-complexed hydrogel based on chitosan/dextran for combining tumor therapy via hypoxia alleviation and TAMs polarity regulation.

Carbohydr Polym 2022 Jul 28;288:119418. Epub 2022 Mar 28.

College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China. Electronic address:

The tumor microenvironment (TME) is characterized by low pH, hypoxia, and infiltrated tumor-associated macrophages (TAMs). Therefore, regulation of TAMs polarization into anti-tumor M1 phenotype and meanwhile alleviation of the hypoxia in TME are expected to improve anti-tumor therapeutic efficacy. To this end, a novel in situ injectable nano-complexed hydrogel was developed in this study for combining tumor therapy. Read More

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Comparative efficacy of citric acid, Spirulina platensis, and their combination as alternatives to an antibiotic growth promoter on the performances of broilers.

J Adv Vet Anim Res 2022 Mar 14;9(1):1-7. Epub 2022 Jan 14.

Department of Animal Nutrition, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.

Objective: A 35-day-long trial was conducted to compare the consequences of supplementing citric acid (CA), , and their combination as natural substitutes for antibiotic growth promoters (AGP) on the productive performance, dressing percentage, and blood serum metabolites of broilers.

Materials And Methods: A total of 150-day-old Cobb-500 broiler chicks were randomly assigned to 5 dietary treatment groups, each having 30 chicks in it (10 chicks per replicate cage). The dietary groups were as follows: 1- Control (corn-soybean-based), 2- Control + antibiotic (Enrofloxacin, 10 mg/kg bodyweight), 3- Control + 1% , 4- Control + 0. Read More

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Synthesis and characterization of phase shift dextran stabilized nanodroplets for ultrasound-induced cancer therapy: A novel nanobiotechnology approach.

J Biotechnol 2022 May 12;350:17-23. Epub 2022 Apr 12.

Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Baqiyatallah University of Medical Sciences, Tehran, Iran.

The nanobiotechnology, one heck of a biotechnology approach, is considered as a focal point in drug delivery systems. Although, plenty of novel approaches are reported in this area, it tackles with strict challenged which confine its broad application. Therefore, there is a need to dig deep into it along with all details. Read More

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Effect of 6% Hydroxyethyl Starch 130/0.4 on Inflammatory Response and Pulmonary Function in Patients Having Cardiac Surgery.

Anesth Analg 2022 05;134(5):e27-e28

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China,

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Maillard induced glycation of β-casein for enhanced stability of the self-assembly micelles against acidic and calcium environment.

Food Chem 2022 Sep 7;387:132914. Epub 2022 Apr 7.

College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Qinghua East Road, Beijing 100083, China; National Engineering Research Center for Fruits and Vegetables Processing, No. 17 Qinghua East Road, Beijing 100083, China. Electronic address:

Bovine β-casein (β-CN) has attracted increasingly interest as biocompatible nanocarrier for hydrophobic flavonoid due to its self-assembly ability to form micelles. This paper reported Maillard induced glycation reaction of β-CN using dextran in order to improve stability of naringenin-loaded β-CN micelles under acidic and high calcium environments. Our results showed that solubility of β-CN-graft-dextran was remarkable increased at acidic pH and the conjugation with 20 kDa dextran had the highest level of graft degree. Read More

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September 2022

Blood Component Requirements and Erythrocyte Transfusion and Mortality Related to Hemoglobin Deficit in Phase III Trial of Hemoglobin-Based Oxygen Carrier: HBOC-201.

Am J Ther 2022 May-Jun 01;29(3):e279-e286. Epub 2022 Apr 14.

Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Background: Hemoglobin-based oxygen carriers (HBOCs) may cause coagulopathy, changes in total hemoglobin (THb), and affect mortality. Low total hemoglobin concentrations [THb] during hemorrhage may worsen outcomes.

Study Question: The database of the Hemopure HEM-0115 phase III trial was queried to determine the use of platelets, plasma, or cryoprecipitate and compare transfusion requirements and coagulation studies between patients randomized to erythrocyte transfusion or HBOC-201 infusion. Read More

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