44,390 results match your criteria Blood Substitutes


Tissue engineering applications in breast cancer.

J Med Eng Technol 2020 May 13:1-7. Epub 2020 May 13.

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

In Iran, breast cancer (BC) is the most prevalent cancer among women. The standard treatment for this cancer is partial or total removal of breast tissue, followed by chemotherapy and radiation. Tissue engineering (TE) has made new treatments for tissue loss in these patients by creating functional substitutes in the laboratory. Read More

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http://dx.doi.org/10.1080/03091902.2020.1757771DOI Listing

Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration.

Int J Mol Sci 2020 May 3;21(9). Epub 2020 May 3.

Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy.

Bone tissue renewal can be outlined as a complicated mechanism centered on the interaction between osteogenic and angiogenic events capable of leading to bone formation and tissue renovation. The achievement or debacle of bone regeneration is focused on the primary role of vascularization occurrence; in particular, the turning point is the opportunity to vascularize the bulk scaffolds, in order to deliver enough nutrients, growth factors, minerals and oxygen for tissue restoration. The optimal scaffolds should ensure the development of vascular networks to warrant a positive suitable microenvironment for tissue engineering and renewal. Read More

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http://dx.doi.org/10.3390/ijms21093242DOI Listing

Estimated population wide benefits and risks in China of lowering sodium through potassium enriched salt substitution: modelling study.

BMJ 2020 04 22;369:m824. Epub 2020 Apr 22.

George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, PO Box M201, Missenden Road, NSW 2050, Australia.

Objectives: To estimate the effects of nationwide replacement of discretionary salt (used at table or during cooking) with potassium enriched salt substitute on morbidity and death from cardiovascular disease in China.

Design: Modelling study.

Setting: China. Read More

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http://dx.doi.org/10.1136/bmj.m824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190075PMC

Thoracic aortic surgery: status and upcoming novelties.

Minerva Cardioangiol 2020 Apr 21. Epub 2020 Apr 21.

Department of Cardiothoracic Surgery Weill Cornell Medicine, Presbyterian Hospital, New York, NY, USA.

Several novel technological developments and surgical approaches have characterized the field of aortic surgery in the recent decade. The progressive introduction of endovascular procedure, minimally invasive surgical techniques and hybrid approaches have changed the practice in aortic surgery and generated new trends and questions. Also, the advancements in the manufacturing of tissue engineered vascular grafts as substitutes for aortic replacements are enlightening new avenues in the treatment of aortic disease. Read More

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http://dx.doi.org/10.23736/S0026-4725.20.05263-9DOI Listing

Artificial Blood: The History and Current Perspectives of Blood Substitutes.

Discoveries (Craiova) 2020 Mar 18;8(1):e104. Epub 2020 Mar 18.

Mount Sinai Health System, Department of Pathology and Laboratory Medicine, Icahn School of Medicine, New York, NY, USA.

Blood transfusions are one of the most common procedures performed in hospitalized patients. Yet, despite all of the measures taken to ensure the safety of the blood supply, there are known risks associated with transfusions, including infectious and noninfectious complications. Meanwhile, issues with blood product availability, the need for compatibility testing, and the storage and transport requirements of blood products, have presented challenges for the administration of blood transfusions. Read More

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http://dx.doi.org/10.15190/d.2020.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086064PMC

Human platelet lysate efficiency, stability, and optimal heparin concentration required in culture of mammalian cells.

Blood Res 2020 Mar 30;55(1):35-43. Epub 2020 Mar 30.

National Organization for Research and Control of Biologicals, Giza, Egypt.

Background: Fetal bovine serum (FBS) has been used to support the growth and proliferation of mammalian cells for decades. Owing to several risk factors associated with FBS, several trials have been conducted to evaluate substitutes to FBS with the same efficiency and the lower risk issues.

Methods: In this study, human platelet lysate (HPL) derived from activated human platelets was evaluated as an alternative to FBS due to the associated risk factors. Read More

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http://dx.doi.org/10.5045/br.2020.55.1.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106120PMC

Azides and Porphyrinoids: Synthetic Approaches and Applications. Part 1-Azides, Porphyrins and Corroles.

Molecules 2020 Apr 3;25(7). Epub 2020 Apr 3.

LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

Azides and porphyrinoids (such as porphyrin and corrole macrocycles) can give rise to new derivatives with significant biological properties and as new materials' components. Significant synthetic approaches have been studied. A wide range of products (e. Read More

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http://dx.doi.org/10.3390/molecules25071662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181322PMC

Vessel graft fabricated by the on-site differentiation of human mesenchymal stem cells towards vascular cells on vascular extracellular matrix scaffold under mechanical stimulation in a rotary bioreactor.

J Mater Chem B 2019 04 26;7(16):2703-2713. Epub 2019 Mar 26.

Department of Biomedical Engineering, University of South Dakota, 4800 N Career Ave, Suite 221, Sioux Falls, SD, USA.

Although a significant number of studies on vascular tissue engineering have been reported, the current availability of vessel substitutes in the clinic remains limited mainly due to the mismatch of their mechanical properties and biological functions with native vessels. In this study, a novel approach to fabricating a vessel graft for vascular tissue engineering was developed by promoting differentiation of human bone marrow mesenchymal stem cells (MSCs) into endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) on a native vascular extracellular matrix (ECM) scaffold in a rotary bioreactor. The expression levels of CD31 and vWF, and the LDL uptake capacity as well as the angiogenesis capability of the EC-like cells in the dynamic culture system were significantly enhanced compared to the static system. Read More

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http://dx.doi.org/10.1039/c8tb03348jDOI Listing

Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.

Wiad Lek 2020 ;73(2):272-277

Higher Education Institution In Ukraine "Bukovinian State Medical University", Chernivtsi, Ukraine.

Objective: The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.

Patients And Methods: Materials and methods: The study included 100 patients with AIS. Read More

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Electrospun novel nanocomposite comprising polyurethane integrated with ayurveda amla oil for bone tissue engineering.

An Acad Bras Cienc 2020 30;92(1):e20180369. Epub 2020 Mar 30.

School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia.

Ayurveda oil contains numerous source of biological constituents which plays an important role in reducing the pain relief caused during bone fracture. The aim of the study is to fabricate the polyurethane (PU) scaffold for bone tissue engineering added with ayurveda amla oil using electrospinning technique. Scanning Electron Microscopy (SEM) analysis showed that the fabricated nanocomposites showed reduced fiber diameter (758 ± 185. Read More

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http://dx.doi.org/10.1590/0001-3765202020180369DOI Listing

Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity.

Fluids Barriers CNS 2020 Mar 30;17(1):25. Epub 2020 Mar 30.

Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, 467-8603, Japan.

Background: In vitro blood-brain barrier (BBB) models using human induced pluripotent stem (iPS) cell-derived brain microvascular endothelial-like cells (iBMELCs) have been developed to predict the BBB permeability of drug candidates. For the differentiation of iBMELCs, Matrigel, which is a gelatinous protein mixture, is often used as a coating substrate. However, the components of Matrigel can vary among lots, as it is obtained from mouse sarcoma cells with the use of special technics and also contains various basement membranes. Read More

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http://dx.doi.org/10.1186/s12987-020-00186-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106710PMC

A label-free aptasensor for highly sensitive detection of homocysteine based on gold nanoparticles.

Bioelectrochemistry 2020 Aug 4;134:107497. Epub 2020 Mar 4.

Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.

In the present study, an original electrode fabrication approach was devised to create a label free sensitive electrochemical aptasensor for the detection of Homocysteine (Hcy) (Homocysteine signal was used for detection). To bind certain targets, synthetic oligonucleotides used as aptamers (APs) were specifically selected. Aptamers are substitutes for antibodies for analytical devices because of their sensitivity and high affinity. Read More

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http://dx.doi.org/10.1016/j.bioelechem.2020.107497DOI Listing
August 2020
4.172 Impact Factor

Improving Self-Care in Patients With Coexisting Type 2 Diabetes and Hypertension by Technological Surrogate Nursing: Randomized Controlled Trial.

J Med Internet Res 2020 Mar 27;22(3):e16769. Epub 2020 Mar 27.

Department of Industrial and Manufacturing Systems Engineering, University of Hong Kong, Hong Kong, Hong Kong.

Background: Technological surrogate nursing (TSN) derives from the idea that nurse-caregiver substitutes can be created by technology to support chronic disease self-care.

Objective: This paper begins by arguing that TSN is a useful and viable approach to chronic disease self-care. The analysis then focuses on the empirical research question of testing and demonstrating the effectiveness and safety of prototype TSN supplied to patients with the typical complex chronic disease of coexisting type 2 diabetes and hypertension. Read More

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http://dx.doi.org/10.2196/16769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148548PMC

Design and synthesis of potent PAR-1 antagonists based on vorapaxar.

Bioorg Med Chem Lett 2020 Apr 17;30(8):127046. Epub 2020 Feb 17.

Hebei University of Technology, Tianjin 300100, China. Electronic address:

A series of novel vorapaxar analogues with different amino substitutes at the C-7, C-9a and aromatic substitutes at the C-4 position were designed, synthesized, and evaluated for their inhibitory activity to PAR-1. Several compounds showed good potency in antagonist activity based on the intracellular calcium mobilization assay and excellent pharmacokinetics profile in rats. Among these analogues, 3d exhibited excellent PAR-1 inhibitory activity (IC = 0. Read More

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http://dx.doi.org/10.1016/j.bmcl.2020.127046DOI Listing
April 2020
2.420 Impact Factor

Preparation of dummy molecularly imprinted polymers based on dextran-modified magnetic nanoparticles FeO for the selective detection of acrylamide in potato chips.

Food Chem 2020 Jul 19;317:126431. Epub 2020 Feb 19.

School of Biotechnology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu 215500, PR China.

Novel dummy magnetic molecularly imprinted polymers (dex-MMIPs) were prepared for highly selective recognition and fast enrichment of acrylamide (AA) in potato chips. Propionamide (PA) was used as dummy template molecule and the FeO nanoparticles modified with carboxymethyl dextran were developed as supports. Methacrylic acid (MAA) and ethyleneglycoldimethacrylate (EGDMA) were chosen as the functional monomer and cross-linker, respectively. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.126431DOI Listing

The hypotensive effect of salt substitutes in stage 2 hypertension: a systematic review and meta-analysis.

BMC Cardiovasc Disord 2020 Feb 27;20(1):98. Epub 2020 Feb 27.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan, University of Medical Sciences, Kashan, IR, Iran.

Background: Hypertension (HTN) is a ubiquitous risk factor for numerous non-communicable diseases, including cardiovascular disease and stroke. There are currently no wholly effective pharmacological therapies for subjects with HTN. However, salt substitutes have emerged as a potential therapy for the treatment of HTN. Read More

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http://dx.doi.org/10.1186/s12872-020-01347-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047420PMC
February 2020
1.500 Impact Factor

Electrosprayed Polymeric Nanospheres for Enhanced Solubility, Dissolution Rate, Oral Bioavailability and Antihyperlipidemic Activity of Bezafibrate.

Int J Nanomedicine 2020 31;15:705-715. Epub 2020 Jan 31.

Department of Pharmacy, COMSATS University Islamabad, Lahore 54000, Pakistan.

Background: Bezafibrate is a BCS class II drug as it presents very low solubility in water; therefore, its bioavailability after oral administration is very poor. The aim of this work was to enhance solubility and dissolution rate of bezafibrate in water in order to enhance its oral bioavailability.

Methods: Several formulations were prepared using PVP K30 and Cremophor ELP employing the solvent-evaporation method and the electrospraying technique. Read More

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http://dx.doi.org/10.2147/IJN.S235146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999775PMC

Transfusion Outcomes in Patients Undergoing Unifocalization and Repair of Tetralogy of Fallot With Major Aortopulmonary Collaterals.

World J Pediatr Congenit Heart Surg 2020 Mar;11(2):159-165

Clinical and Translational Research Program, Lucile Packard Children's Hospital Heart Center, Stanford University, Stanford, CA, USA.

Background: Surgical repair of tetralogy of Fallot and major aortopulmonary collaterals (TOF/MAPCAs) involves unifocalization of MAPCAs and reconstruction of the pulmonary arterial circulation. Surgical and cardiopulmonary bypass (CPB) times are long and suture lines are extensive. Maintaining patency of the newly anastomosed vessels while achieving hemostasis is important, and assessment of transfusion practices is critical to successful outcomes. Read More

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http://dx.doi.org/10.1177/2150135119892192DOI Listing

A systematic multidisciplinary initiative may reduce the need for blood products in patients with abnormally invasive placenta.

J Matern Fetal Neonatal Med 2020 Feb 23:1-7. Epub 2020 Feb 23.

Abnormally Invasive Placenta Clinic, Fundación Valle del Lili, Cali, Colombia.

The main complication of the abnormally invasive placenta is massive bleeding, with transfusions required frequently. We aim to evaluate the impact of interdisciplinary management on transfusion practices in women with abnormally invasive placenta. Clinical outcomes of women with abnormally invasive placenta treated between 2011 and 2019 were reviewed, including transfusion frequency. Read More

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http://dx.doi.org/10.1080/14767058.2020.1731460DOI Listing
February 2020

Effects of gold nanoparticles in gilthead seabream-A proteomic approach.

Aquat Toxicol 2020 Apr 11;221:105445. Epub 2020 Feb 11.

Departamento de Biologia & CESAM, Universidade de Aveiro, 3810-193, Aveiro, Portugal.

Despite the widespread use of nanoparticles (NPs), there are still major gaps of knowledge regarding the impact of nanomaterials in the environment and aquatic animals. The present work aimed to study the effects of 7 and 40 nm gold nanoparticles (AuNPs) - citrate and polyvinylpyrrolidone (PVP) coated - on the liver proteome of the estuarine/marine fish gilthead seabream (Sparus aurata). After 96 h, exposure to AuNP elicited alterations on the abundance of 26 proteins, when compared to the control group. Read More

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http://dx.doi.org/10.1016/j.aquatox.2020.105445DOI Listing

Effect of salt reduction interventions in lowering blood pressure in Chinese populations: a systematic review and meta-analysis of randomised controlled trials.

BMJ Open 2020 Feb 17;10(2):e032941. Epub 2020 Feb 17.

Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China

Rationale And Objective: Salt reduction remains a global challenge and different salt reduction strategies have been studied in China. This study is to systematically evaluate evidence from randomised controlled trials (RCT) in China and inform the effective salt reduction strategies.

Design: Systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-032941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044858PMC
February 2020

Effect of salt substitution on community-wide blood pressure and hypertension incidence.

Nat Med 2020 03 17;26(3):374-378. Epub 2020 Feb 17.

CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.

Replacement of regular salt with potassium-enriched substitutes reduces blood pressure in controlled situations, mainly among people with hypertension. We report on a population-wide implementation of this strategy in a stepped-wedge cluster randomized trial (NCT01960972). The regular salt in enrolled households was retrieved and replaced, free of charge, with a combination of 75% NaCl and 25% KCl. Read More

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http://dx.doi.org/10.1038/s41591-020-0754-2DOI Listing

A Blood-Free Diet to Rear Anopheline Mosquitoes.

J Vis Exp 2020 Jan 31(155). Epub 2020 Jan 31.

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, IHMT-NOVA;

Malaria research requires large-scale breeding and production conditions for mosquitoes (Anopheles spp.) in captivity. The sustainable and reliable production of mosquitoes is currently inhibited by the supply of fresh vertebrate blood. Read More

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http://dx.doi.org/10.3791/60144DOI Listing
January 2020

Synergism between recombinant human bone morphogenetic protein 2/absorbable collagen sponge and bone substitutes favor vertical bone augmentation and the resorption rate of the biomaterials: Histomorphometric and 3D microcomputed tomography analysis.

J Periodontol 2020 Feb 13. Epub 2020 Feb 13.

Department of Oral and Maxillofacial Surgery and Traumatology, School of Dentistry, University of São Paulo (USP), São Paulo, Brazil.

Background: Recombinant human bone morphogenetic protein 2 (rhBMP-2) is an osteoinductor frequently used for bone regeneration in oral and maxillofacial surgery. There is no consensus about the ideal carrier for this growth factor. The aim of this study was to compare the bone augmentation, bone microarchitecture, and biodegradation rate of additional carriers to rhBMP-2/absorbable collagen sponge (ACS) in a vertical guided bone regeneration model. Read More

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http://dx.doi.org/10.1002/JPER.19-0571DOI Listing
February 2020

Interfacial tension and mechanism of liquid-liquid phase separation in aqueous media.

Phys Chem Chem Phys 2020 Feb;22(8):4574-4580

Cleveland Diagnostics, Cleveland, OH, USA.

The organization of multiple subcellular compartments is controlled by liquid-liquid phase separation. Phase separation of this type occurs with the emergence of interfacial tension. Aqueous two-phase systems formed by two non-ionic polymers can be used to separate and analyze biological macromolecules, cells and viruses. Read More

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http://dx.doi.org/10.1039/c9cp05810aDOI Listing
February 2020

Histologic Comparison of the Dura Mater among Species.

Comp Med 2020 Apr 3;70(2):170-175. Epub 2020 Feb 3.

Department of Neurology and Neurosurgery, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Brain Technology Institute, Utrecht, The Netherlands; Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

The biocompatibility, biodegradation, feasibility, and efficacy of medical devices like dural sealants and substitutes are often evaluated in various animal models. However, none of these studies explain the rationale for choosing a particular species, and a systematic interspecies comparison of the dura is not available. We hypothesized that histologic characteristics of the dura would differ among species. Read More

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http://dx.doi.org/10.30802/AALAS-CM-19-000022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137549PMC

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in a small child: A case report.

Medicine (Baltimore) 2020 Jan;99(3):e18759

Department of Pediatrics, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania.

Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a rare, potentially lethal disorder, characterized by a dysregulation of the immune response, leading to a severe inflammatory syndrome. Epstein-Barr virus (EBV)-associated HLH is a form of secondary HLH, a fulminant presentation of an otherwise benign viral infection.

Patient Concerns: We report the case of a 3-year-old girl who presented with fever, signs of accute upper respiratory tract infection and spontaneous, disseminated ecchymoses. Read More

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http://dx.doi.org/10.1097/MD.0000000000018759DOI Listing
January 2020

Acute cytotoxic effects of silica microparticles used for coating of plastic blood-collection tubes on human periosteal cells.

Odontology 2020 Jan 30. Epub 2020 Jan 30.

Division of Oral Bioengineering, Institute of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.

Because of its simple operation, platelet-rich fibrin (PRF) is becoming more popular than the original form, platelet-rich plasma (PRP), in regenerative dentistry. PRF preparation requires plain glass blood-collection tubes, but not either anticoagulants or coagulation factors. However, such glass tubes designed for laboratory testing are no longer commercially available. Read More

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http://dx.doi.org/10.1007/s10266-020-00486-zDOI Listing
January 2020

Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.

Authors:
Fei Xu Yubo Fan

J Biomed Nanotechnol 2020 Jan;16(1):101-110

Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice. However, small-diameter (< 6 mm) synthetic grafts have not been applied due to their hydrophobicity. In this study, poly-vinylpyrrolidone (PVP) was introduced into poly-L-lactic acid (PLLA) to prepare biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA). Read More

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http://dx.doi.org/10.1166/jbn.2020.2877DOI Listing
January 2020
5.338 Impact Factor

Reply: Hyaluronic Acid-Povidone-Iodine Compound Facilitates Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Rodent Model.

Plast Reconstr Surg 2020 02;145(2):455e-456e

Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1097/PRS.0000000000006450DOI Listing
February 2020

Hyaluronic Acid-Povidone-Iodine Compound Facilitates Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Rodent Model.

Plast Reconstr Surg 2020 02;145(2):454e-455e

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong Universtiy, School of Medicine, Shandong University, Jinan, Shandong, China Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and, Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1097/PRS.0000000000006449DOI Listing
February 2020

Autologous plasma versus fetal calf serum as a supplement for the culture of neutrophils.

BMC Res Notes 2020 Jan 22;13(1):39. Epub 2020 Jan 22.

Immunology Department, Medical School, Isfahan University of Medical Sciences, Hezar Jerib Street, Isfahan, Iran.

Objective: Currently, the replacement of fetal calf serum (FCS) by a more suitable alternative is a sought aim in the field of tissue and cell culture research. Autologous plasma (AP) and especially autologous serum (AS) have been shown to be effective substitutes of FCS in culture media for some of the cell types. Nevertheless, there is no comparative data on the most appropriate supplement for cell media in neutrophil studies, it is now unclear whether AP have a relatively equal, superior or inferior performance to FCS in neutrophil cell culture. Read More

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http://dx.doi.org/10.1186/s13104-020-4902-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977324PMC
January 2020

Socket preservation using eggshell-derived nanohydroxyapatite with platelet-rich fibrin as a barrier membrane: a new technique.

J Korean Assoc Oral Maxillofac Surg 2019 Dec 26;45(6):332-342. Epub 2019 Dec 26.

Department of Oral and Maxillofacial Pathology, Sibar Institute of Dental Sciences, Guntur, India.

Objectives: Socket grafting is vital to prevent bone resorption after tooth extraction. Several techniques to prevent resorption have been described, and various bone graft substitutes have been developed and used with varying success. We conducted this pilot study to evaluate the performance of nanohydroxyapatite (nHA) derived from chicken eggshells in socket preservation. Read More

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http://dx.doi.org/10.5125/jkaoms.2019.45.6.332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955417PMC
December 2019

Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial.

JAMA 2020 01;323(3):225-236

CHU Montpellier, Département Anesthésie et Réanimation B (DAR B), Hôpital Saint-Eloi, and Inserm U-1046, Montpellier, France.

Importance: It is not known if use of colloid solutions containing hydroxyethyl starch (HES) to correct for intravascular deficits in high-risk surgical patients is either effective or safe.

Objective: To evaluate the effect of HES 130/0.4 compared with 0. Read More

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http://dx.doi.org/10.1001/jama.2019.20833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990683PMC
January 2020

Hydroxyethyl Starch for Fluid Replacement Therapy in High-Risk Surgical Patients: Context and Caution.

JAMA 2020 01;323(3):217-218

Research Institute, HCor (Hospital do Coração), São Paulo, Brazil.

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http://dx.doi.org/10.1001/jama.2019.20141DOI Listing
January 2020

Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer.

Drug Discov Ther 2019 ;13(6):343-353

Laboratory of Pharmaceutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.

Conventional oral preparations generally release incorporated drugs omnidirectionally, including into the lumen, leading to a low bioavailability of drugs that are unstable in the gastrointestinal tract. Here, we designed Janus microspheres for efficient mucosal drug delivery as single-sided-release microspheres with the oriented attachment to mucus and evaluated their attachment to and orientation on a Caco-2 (human Caucasian colon adenocarcinoma cell line) monolayer. The microspheres comprised a mucus-oriented hemisphere of an ammonioalkyl methacrylate copolymer and a protective hemisphere of a hard fat. Read More

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http://dx.doi.org/10.5582/ddt.2019.01090DOI Listing

Effects of anaesthesia-induced hypotension and phenylephrine on plasma volume expansion by hydroxyethyl starch: A randomised controlled study.

Acta Anaesthesiol Scand 2020 May 30;64(5):620-627. Epub 2020 Jan 30.

Department of Anaesthesiology and Pain Medicine, Hyogo College of Medicine, Hyogo, Japan.

Background: Changes in blood haemoglobin concentration indicate plasma volume expansion following hydroxyethyl starch (HES) infusion, but may be affected by vascular tone and HES-induced shedding of the endothelial surface layer (ESL). We hypothesised that anaesthesia-induced hypotension enhances changes in plasma volume as assessed by blood haemoglobin concentration (ΔPV , %) following HES infusion.

Methods: Fifty-two patients undergoing abdominal surgery were randomised to receive a continuous infusion of saline (S group) or phenylephrine to restore vascular tone (P group) (n = 26 each). Read More

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http://dx.doi.org/10.1111/aas.13548DOI Listing

Short-Segment Instrumentation with Fractured Vertebrae Augmentation by Screws and Bone Substitute for Thoracolumbar Unstable Burst Fractures.

Biomed Res Int 2019 26;2019:4780426. Epub 2019 Dec 26.

Department of Orthopedics Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.

Background: For thoracolumbar burst fractures, traditional four-screw (one above and one below) short-segment instrumentation is popular and has a high failure rate. Additional augmentation at the fractured vertebrae is believed to reduce surgical failure. The purpose of this study was to examine the clinical and radiographic results of patients who underwent short-segment posterior instrumentation with augmentation by screws and bone substitutes at the fractured vertebrae and to compare these data to those of patients who underwent long-segment instrumentation for thoracolumbar burst fractures. Read More

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http://dx.doi.org/10.1155/2019/4780426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948339PMC
December 2019

Urinary bisphenol A and its analogues and haemato-biochemical alterations of pregnant women in Korea.

Environ Res 2020 Mar 3;182:109104. Epub 2020 Jan 3.

National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea. Electronic address:

Introduction: Bisphenol F (BPF) and bisphenol S (BPS) are chemical substitutes for, and may have similar physiological effects to, bisphenol A (BPA). Bisphenols provoke endocrine disorders and are cytotoxic, oxidize hemoglobin, and induce morphological changes in human red blood cells (RBC). It is more sensitive to changes in the RBC number and hemoglobin (Hb) level during pregnancy. Read More

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http://dx.doi.org/10.1016/j.envres.2019.109104DOI Listing

Polylactide-Based Reactive Micelles as a Robust Platform for mRNA Delivery.

Pharm Res 2020 Jan 8;37(2):30. Epub 2020 Jan 8.

Aix Marseille Université, CNRS, ICR UMR 7273, 13397, Marseille, France.

Purpose: mRNA has recently emerged as a potent therapeutics and requires safe and effective delivery carriers, particularly prone to address its issues of poor stability and escape from endosomes. In this context, we designed poly(D,L-lactide) (PLA)-based micelles with N-succinimidyl (NS) ester decorated hydrophilic hairy corona to trap/couple a cationic fusogenic peptide and further complex mRNA.

Methods: Two strategies were investigated, namely (i) sequential immobilization of peptide and mRNA onto the micelles (layer-by-layer, LbL) or (ii) direct immobilization of peptide-mRNA pre-complex (PC) on the micelles. Read More

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http://dx.doi.org/10.1007/s11095-019-2749-6DOI Listing
January 2020

Sustainable Dissolution Performance of a Carrier Tailored Electrospun.

Pharm Res 2020 Jan 7;37(2):28. Epub 2020 Jan 7.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Purpose: This study aims to conduct an impact investigation in the hydrophobic-hydrophilic balance as an important factor for dissolution improvement of a hydrophilic carrier-based solid dispersion system.

Methods: Polymeric carriers with different hydrophobic to hydrophilic ratios were used to prepare several electrospun solid dispersion formulations. Physicochemical properties and surface morphology of the samples were assessed using Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR), polarized light microscopy, Differential Scanning Calorimetry (DSC), X-ray Powder Diffraction (XRPD) and Scanning Electron Microscopy (SEM). Read More

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http://dx.doi.org/10.1007/s11095-019-2734-0DOI Listing
January 2020

Barbaloin Attenuates Mucosal Damage in Experimental Models of Rat Colitis by Regulating Inflammation and the AMPK Signaling Pathway.

Med Sci Monit 2019 Dec 27;25:10045-10056. Epub 2019 Dec 27.

Department of Intervention, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (mainland).

BACKGROUND Barbaloin is one of the main medicinal ingredients of aloe vera, which displays various anti-inflammatory and anti-apoptosis properties in several inflammatory and fibrotic diseases. Our study evaluated its efficacy against dextran sulfate sodium (DSS)-induced colitis in rats. MATERIAL AND METHODS Ulcerative colitis (UC) rat models were established in vivo, and after barbaloin treatment, body weight and inflammation index were measured. Read More

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http://dx.doi.org/10.12659/MSM.918935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946048PMC
December 2019

Long Term Evaluation of Nanofibrous, Bioabsorbable Polycarbonate Urethane Grafts for Small Diameter Vessel Replacement in Rodents.

Eur J Vasc Endovasc Surg 2020 04 23;59(4):643-652. Epub 2019 Dec 23.

Centre for Biomedical Research, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Medical University of Vienna, Vienna, Austria. Electronic address:

Objective: Biodegradable materials for in situ vascular tissue engineering could meet the increasing clinical demand for sufficient synthetic small diameter vascular substitutes in aortocoronary bypass and peripheral vascular surgery. The aim of this study was to design a new degradable thermoplastic polycarbonate urethane (dPCU) with improved biocompatibility and optimal biomechanical properties. Electrospun conduits made from dPCU were evaluated in short and long term follow up and compared with expanded polytetrafluoroethylene (ePTFE) controls. Read More

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http://dx.doi.org/10.1016/j.ejvs.2019.11.004DOI Listing

Design and Optimization of a Temperature-Stable Dry Powder BCG Vaccine.

Pharm Res 2019 Dec 23;37(1):11. Epub 2019 Dec 23.

Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Health Sciences Center, Albuquerque, New Mexico, 87131, USA.

Purpose: Loss of vaccine potency due to extreme temperature exposure during storage and transport remains a significant obstacle to the success of many vaccines, including the Bacille Calmette-Guérin (BCG) vaccine, the only vaccine available against Mycobacterium tuberculosis. BCG is a live, attenuated vaccine requiring refrigerated storage for viability. In this study, we formulated a temperature-stable BCG dry powder using the spray drying technique. Read More

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http://dx.doi.org/10.1007/s11095-019-2739-8DOI Listing
December 2019

Surface Composition and Formulation Heterogeneity of Protein Solids Produced by Spray Drying.

Pharm Res 2019 Dec 23;37(1):14. Epub 2019 Dec 23.

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana, 47907, USA.

Purpose: The aim of this study is to determine the effects of saccharide-containing excipients on the surface composition of spray-dried protein formulations and their matrix heterogeneity.

Methods: Spray-dried formulations of myoglobin or bovine serum albumin (BSA) were prepared without excipient or with sucrose, trehalose, or dextrans. Samples were characterized by solid-state Fourier-transform infrared spectroscopy (ssFTIR), differential scanning calorimetry (DSC), size exclusion chromatography (SEC) and scanning electron microscopy (SEM). Read More

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http://dx.doi.org/10.1007/s11095-019-2738-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227480PMC
December 2019

Enhanced electrochemiluminescence of luminol based on CuO-Au heterostructure enabled multiple-amplification strategy.

Biosens Bioelectron 2020 Mar 16;151:111970. Epub 2019 Dec 16.

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China.

Herein, a credible construction strategy to improve electrochemiluminescence (ECL) of luminol was developed based on CuO-Au heterostructures. Summarily, gold nanoparticles (AuNPs) were anchored on surface of CuO nanocube (CuO@AuNPs) by spontaneous reduction reaction. Then, luminol molecules were concentrated on CuO@AuNPs using L-Cysteine (Cys) as covalent linkage to build the composite emitter (CuO@AuNPs-Cys-luminol). Read More

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http://dx.doi.org/10.1016/j.bios.2019.111970DOI Listing

Is it time for South Africa to end the routine high-dose vitamin A supplementation programme?

S Afr Med J 2019 Nov 27;109(12):907-910. Epub 2019 Nov 27.

School of Clinical Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

In accordance with World Health Organization guidelines, South Africa (SA) introduced routine periodic high-dose vitamin A supplementation (VAS) in 2002. These guidelines were developed after research in the 1980s and 1990s showed the efficacy of VAS in reducing childhood mortality. However, two recent studies in low- to middle-income countries (2013 and 2014) have shown no effect of high-dose VAS on mortality. Read More

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http://dx.doi.org/10.7196/SAMJ.2019.v109i12.14203DOI Listing
November 2019

Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T Weighted Magnetic Resonance Imaging.

Molecules 2019 Dec 17;24(24). Epub 2019 Dec 17.

CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse CEDEX 4, France.

The growing concern over the toxicity of Gd-based contrast agents used in magnetic resonance imaging (MRI) motivates the search for less toxic and more effective alternatives. Among these alternatives, iron-iron oxide (Fe@FeOx) core-shell architectures have been long recognized as promising MRI contrast agents while limited information on their engineering is available. Here we report the synthesis of 10 nm large Fe@FeOx nanoparticles, their coating with a 11 nm thick layer of dense silica and functionalization by 5 kDa PEG chains to improve their biocompatibility. Read More

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http://dx.doi.org/10.3390/molecules24244629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943426PMC
December 2019

Nanomedicines: A Potential Treatment for Blood Disorder Diseases.

Front Bioeng Biotechnol 2019 28;7:369. Epub 2019 Nov 28.

Chinese Academy of Inspection and Quarantine, Beijing, China.

Blood disorder diseases (BDDs), also known as hematologic, is one of the diseases owing to hematopoietic system disorder. Chemotherapy, bone marrow transplantation, and stem cells therapy have been used to treat BDDs. However, the cure rates are still low due to the availability of the right type of bone marrow and the likelihood of recurrence and infection. Read More

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http://dx.doi.org/10.3389/fbioe.2019.00369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892756PMC
November 2019