43,580 results match your criteria Blood Substitutes


Searching for a bisphenol A substitute: Effects of bisphenols on catalase molecules and human red blood cells.

Sci Total Environ 2019 Mar 10;669:112-119. Epub 2019 Mar 10.

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, Shandong Province, PR China. Electronic address:

Some countries are limiting the use of BPA. To meet the challenge of finding a suitable alternative requires safety assessments of the common analogs of BPA. Bisphenol S (BPS), Bisphenol F (BPF) and Bisphenol B (BPB) are increasingly used as substitutes and the aim of this study is to assess their human health implications. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.129DOI Listing

Acute effect of an amino acid mixture in the rat glycemic profile.

J Cell Biochem 2019 Mar 14. Epub 2019 Mar 14.

Faculdade de Ciências da Nutrição e Alimentação, Universidade do Porto, Porto, Portugal.

Amino acid mixtures (AAM) are protein substitutes used for phenylketonuria treatment, but their metabolic effects have not been well characterized. The objective of this study was to compare the acute glycemic response to free amino acids (free AA) from AAM with the response to intact protein (iProtein). Male Wistar rats (n = 14) were administered by gavage a bolus of free AA (n = 7) or iProtein as albumin (n = 7) containing equivalent amounts of nitrogen. Read More

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http://dx.doi.org/10.1002/jcb.28576DOI Listing

Regeneration of trachea graft with cartilage support, vascularization, and epithelization.

Acta Biomater 2019 Mar 10. Epub 2019 Mar 10.

Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, PR China; National Tissue Engineering Center of China, Shanghai, PR China. Electronic address:

The repair and functional reconstruction of long-segment tracheal defects is always a great challenge in the clinic. Finding an ideal substitute for tracheal transplantation is the only way to solve this problem. The current study proposed a series of novel strategies for constructing a bionic living trachea substitute. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.003DOI Listing

Artificial Oxygen Carriers and Red Blood Cell Substitutes: An Historic Overview and Recent Developments Toward Military and Clinical Relevance.

J Trauma Acute Care Surg 2019 Mar 8. Epub 2019 Mar 8.

Trauma Center at Penn, Department of Surgery, University of Pennsylvania, Philadelphia, PA, 19104.

Packed red blood cells are a critical component in the resuscitation of hemorrhagic shock. The availability of donor-derived blood products, however, suffers from issues of supply, immunogenicity, and pathogenic contamination. Deployment in remote or austere environments, such as the battlefield, is further hindered by the inherent perishability of blood products. Read More

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http://dx.doi.org/10.1097/TA.0000000000002250DOI Listing
March 2019
1 Read

Assessing the Thrombogenic Potential of Heart Valve Prostheses: An Approach for a Standardized In-Vitro Method.

Cardiovasc Eng Technol 2019 Mar 6. Epub 2019 Mar 6.

Department of Cardiovascular Engineering, Helmholtz Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany.

Purpose: Thrombogenic complications are still a main issue in the general performance of cardiovascular implants, especially heart valves. To date, the thrombogenic potential of those prostheses is pre-clinically assessed in time consuming animal studies with questionable evidence.

Methods: In this study, we present a new in-vitro method to assess and compare deficiencies of heart valve substitutes concerning their thrombogenic performance and locate initial clot formation under physiological conditions using porcine blood. Read More

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http://dx.doi.org/10.1007/s13239-019-00408-3DOI Listing
March 2019
1 Read

Assessing the effect of sugar type and form of its intake on selected parameters of carbohydrate-lipid metabolism and plasma atherogenic indices in rats

Rocz Panstw Zakl Hig 2019 ;70(1):59-67

West Pomeranian University of Technology in Szczecin, Faculty of Food Sciences and Fisheries, Department of Human Nutrition Physiology, al. Piastów 17, 70-310 Szczecin, Poland

Background: Over the past 50 years, the average consumption of sugar worldwide has tripled, also the type of consumed sugar has changed. Due to high price of sucrose and its technological disadvantages, high fructose corn syrup (HFCS) has become one of the most commonly used substitutes.

Objective: The aim of the study was to compare, on the animal model, the effect of sugar type (sucrose vs high fructose corn syrup 55% of fructose) and the sugar form (solid vs fluid and solid) on the chosen parameters of carbohydrate-lipid metabolism. Read More

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http://wydawnictwa.pzh.gov.pl/roczniki_pzh/pobierz-artykul?i
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http://dx.doi.org/10.32394/rpzh.2019.0055DOI Listing
January 2019
3 Reads

Artificial oxygen carriers- past, present and the future-a review of the most innovative and clinically relevant concepts.

J Pharmacol Exp Ther 2019 Mar 5. Epub 2019 Mar 5.

Muenster University.

Blood transfusions are daily practice in hospitals. As these products are limited in availability and have various, harmful side-effects, researchers have pursued the goal to develop artificial blood components for about 40 years. Development of oxygen therapeutics and stem cells are more recent goals. Read More

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http://dx.doi.org/10.1124/jpet.118.254664DOI Listing
March 2019
1 Read

Blood Conservation: Exploring Alternatives to Blood Transfusions.

Crit Care Nurs Q 2019 Apr/Jun;42(2):187-191

School of Nursing, Fayetteville State University, Fayetteville, North Carolina (Ms Hudgins). Ms Carter is a telephone triage nurse at Cape Fear Valley Medical Center, Fayetteville, North Carolina.

The conservation of blood products and the use of alternatives to blood transfusion are the best practice. Patients treated with blood conservation techniques will have a reduced risk of blood-borne diseases and a reduced risk of human error that can occur during blood processing. The bedside nurse plays a vital role in educating the patient and the caregiver regarding risks, benefits, and alternatives. Read More

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http://dx.doi.org/10.1097/CNQ.0000000000000252DOI Listing
March 2019
1 Read

Impact of Dual-Layer Duraplasty During Hemicraniectomy on Morbidity and Operative Metrics of Cranioplasty: A Retrospective Case-Control Study Comparing a Single-Layer with a Dual-Layer Technique.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA; Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Background: Dural substitutes used during hemicraniectomy provide a barrier and dissection plane during subsequent cranioplasty. A recent review by our group showed that use of dural substitutes in hemicraniectomy is associated with reduction in estimated blood loss (EBL) and operative time (OT). In our experience, the use of a dual-layer technique facilitates a dissection plane with minimal adhesions. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.276DOI Listing
February 2019

The effects of perioperative intravenous fluid administration strategy on renal outcomes in patients undergoing cardiovascular surgery: An observational study.

Medicine (Baltimore) 2019 Feb;98(7):e14383

Department of Anesthesiology and Pain Medicine.

We assessed whether perioperative fluid management with balanced solutions and a limited volume of hydroxyethyl starch (renal-protective fluid management [RPF] strategy) could improve renal outcomes after cardiovascular surgery.For this retrospective observational study, we evaluated 2613 patients who underwent cardiovascular surgery from January 1, 2010 to December 31, 2013. The control group were given intravenous fluids with saline-based solutions and unlimited volumes of hydroxyethyl starch solutions and the RPF group were given intravenous fluids with RPF. Read More

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http://dx.doi.org/10.1097/MD.0000000000014383DOI Listing
February 2019

Postoperative subdural hematoma with blood flow from an epidural hematoma through a tear at the suture point of an artificial dura substitute.

Acta Neurochir (Wien) 2019 Feb 14. Epub 2019 Feb 14.

Department of Neurosurgery, Cerebrovascular Research Institute, Eisyokai Yoshida Hospital, Daikai-dori9-2-6, Hyogo-ku, Kobe, 652-0803, Japan.

Objective: We have recently seen cases of postoperative epidural and subdural hematomas after duraplasty with an artificial dura substitute. In these cases, the epidural hematoma flowed into the subdural space through a tear at the suture point of the artificial dura substitute. In this study, whether such hematomas are specific to a certain artificial dura substitute was investigated, and the cause and risk factors were examined. Read More

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http://dx.doi.org/10.1007/s00701-019-03830-7DOI Listing
February 2019
1 Read

Endoscopic Management of Vesicoureteral Reflux and Long-term Follow-up.

Indian Pediatr 2018 Dec;55(12):1046-1049

Department of Nuclear Medicine, PGIMER, Chandigarh, India.

Objective: To report our experience with endoscopic management of vesicoureteral reflux (VUR) by injection of a tissue bulking substance - Dextranomer/ hyaluronic acid co-polymer at vesicoureteric junction.

Design: Retrospective analyses of case records.

Setting: Pediatric Surgery department in a tertiary care government Institute. Read More

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December 2018
2 Reads

Dose distribution verification in high-dose-rate brachytherapy using a highly sensitive normoxic N-vinylpyrrolidone polymer gel dosimeter.

Phys Med 2019 Jan 26;57:72-79. Epub 2018 Dec 26.

School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan; Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa, Japan.

Rapid technological advances in high-dose-rate brachytherapy have led to a requirement for greater accuracy in treatment planning system calculations and in the verification of dose distributions. In high-dose-rate brachytherapy, it is important to measure the dose distribution in the low-dose region at a position away from the source in addition to the high-dose range in the proximity of the source. The aim of this study was to investigate the accuracy of a treatment plan designed for prostate cancer in the low-dose range using a normoxic N-vinylpyrrolidone-based polymer gel (VIPET gel) dosimeter containing inorganic salt as a sensitizer (iVIPET). Read More

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http://dx.doi.org/10.1016/j.ejmp.2018.12.007DOI Listing
January 2019
3 Reads

The effect of nacre extract on cord blood-derived endothelial progenitor cells: A natural stimulus to promote angiogenesis?

J Biomed Mater Res A 2019 Feb 8. Epub 2019 Feb 8.

Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), UMR 7365, CNRS-Université de Lorraine, Vandœuvre-Lès-Nancy, F-54505, France.

Angiogenesis is a critical parameter to consider for the development of tissue-engineered bone substitutes. The challenge is to promote sufficient vascularization in the bone substitute to prevent cell death and to allow its efficient integration. The capacity of nacre extract to restore the osteogenic activity of osteoarthritis osteoblasts has already been demonstrated. Read More

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http://dx.doi.org/10.1002/jbm.a.36655DOI Listing
February 2019
3 Reads

Improving the Production of Cofactor-Containing Proteins: Production of Human Hemoglobin in Yeast.

Methods Mol Biol 2019 ;1923:243-264

Department of Biology and Biological Engineering, Systems and Synthetic Biology, Chalmers University of Technology, Gothenburg, Sweden.

Human hemoglobin is an essential protein, whose main function as an oxygen carrier is indispensable for life. Hemoglobin is a cofactor-containing protein with heme as prosthetic group. Same as in humans, heme is synthesized in many organisms in a complex pathway involving two cellular compartments (mitochondria and cytosol), which is tightly regulated. Read More

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http://dx.doi.org/10.1007/978-1-4939-9024-5_11DOI Listing
January 2019
1 Read

Effect of restrictive fluid therapy with hydroxyethyl starch during esophagectomy on postoperative outcomes: a retrospective cohort study.

BMC Surg 2019 Feb 4;19(1):15. Epub 2019 Feb 4.

Department of Anesthesiology and Pain Medicine, Laboratory for Perioperative Outcomes Analysis and Research, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Background: To improve prognosis after esophageal surgery, intraoperative fluid optimization is important. Herein, we hypothesized that hydroxyethyl starch administration during esophagectomy reduce the total amount of fluid infused and it could have a positive effect on postoperative complication occurrence and mortality.

Methods: All consecutive adult patients who underwent elective esophageal surgery for cancer were studied. Read More

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http://dx.doi.org/10.1186/s12893-019-0482-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360773PMC
February 2019
1 Read

Nanomaterials as potential and versatile platform for next generation tissue engineering applications.

J Biomed Mater Res B Appl Biomater 2019 Jan 28. Epub 2019 Jan 28.

Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India.

Tissue engineering (TE) is an emerging field where alternate/artificial tissues or organ substitutes are implanted to mimic the functionality of damaged or injured tissues. Earlier efforts were made to develop natural, synthetic, or semisynthetic materials for skin equivalents to treat burns or skin wounds. Nowadays, many more tissues like bone, cardiac, cartilage, heart, liver, cornea, blood vessels, and so forth are being engineered using 3-D biomaterial constructs or scaffolds that could deliver active molecules such as peptides or growth factors. Read More

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http://dx.doi.org/10.1002/jbm.b.34327DOI Listing
January 2019
2 Reads

Potential use of salt substitutes to reduce blood pressure.

J Clin Hypertens (Greenwich) 2019 Mar 28;21(3):350-354. Epub 2019 Jan 28.

The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/jch.13482DOI Listing
March 2019
1 Read

Double stimuli-responsive polysaccharide block copolymers as green macrosurfactants for near-infrared photodynamic therapy.

Soft Matter 2019 Feb;15(6):1423-1434

Institut für Pharmazie und Biochemie, Johannes Gutenberg-Universität Mainz, Staudingerweg 5, 55128 Mainz, Germany.

The NIR absorbing photosensitizer phthalocyanine zinc (PC(Zn)) was stabilized in aqueous media as water-dispersible nanoparticles with a reduction- and pH-responsive full polysaccharide block copolymer. A cellular uptake and also photo switchable intracellular activity of the cargo upon irradiation at wavelengths in the near infrared region were shown. The block copolymer was synthesized by applying a copper-free click strategy based on a thiol exchange reaction, creating an amphiphilic double-stimuli-responsive mixed disulfide. Read More

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http://dx.doi.org/10.1039/c8sm02204fDOI Listing
February 2019
2 Reads

Effect of low-sodium salt substitutes on blood pressure, detected hypertension, stroke and mortality.

Heart 2019 Jan 19. Epub 2019 Jan 19.

CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.

Objective: A systematic review and meta-analysis was conducted to assess the efficacy of low-sodium salt substitutes (LSSS) as a potential intervention to reduce cardiovascular (CV) diseases.

Methods: Five engines and ClinicalTrials.gov were searched from inception to May 2018. Read More

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-314036
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http://dx.doi.org/10.1136/heartjnl-2018-314036DOI Listing
January 2019
7 Reads

Neutrophil isolation from feline blood using discontinuous Percoll dilutions.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Dec 18;46(6):399-402. Epub 2019 Jan 18.

Objective: Some studies have performed in vitro neutrophil isolation from feline blood. The major limiting factor for these studies is the small volume of blood that can be collected without development of potentially life-threatening complications. In the present study we attempted neutrophil isolation from feline venous blood samples using discontinuous Percoll gradients. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1677404
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http://dx.doi.org/10.1055/s-0038-1677404DOI Listing
December 2018
10 Reads

Application of Texture Analysis Technique in Formulation Development of Lyophilized Orally Disintegrating Tablets Containing Mannitol, Polyvinylpyrrolidone and Amino Acids.

AAPS PharmSciTech 2019 Jan 10;20(2):71. Epub 2019 Jan 10.

Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, Leicester, UK.

Orally disintegrating tablets (ODTs) attract a great attention as this easy swallowing dosage form often improves patient compliance. In the current work, orally disintegrating tablets comprising mannitol, polyvinylpyrrolidone (PVP) and an amino acid (alanine, glycine or serine) with various PVP-to-amino acid ratios were formulated. The combination of mannitol and an amino acid was aimed to use the advantages of mannitol, the matrix-supporting and disintegration agent, and to reduce the total amount of sugar/polyol in tablets. Read More

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http://dx.doi.org/10.1208/s12249-018-1269-8DOI Listing
January 2019
2 Reads

Novel electrochemical sensing platform based on a nanocomposite of PVA/PVP/RGO applied to IgG anti- Toxoplasma gondii antibodies quantitation.

Talanta 2019 Apr 30;195:699-705. Epub 2018 Nov 30.

INQUISAL, Departamento de Química, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 917, D5700BWS San Luis, Argentina. Electronic address:

This article describes the development of a new electrochemical platform composed by a polymer mixture and graphene oxide (GO). The working electrode of a screen-printed carbon electrode (SPCE) was modified with nanocomposite constituted by poly-vinyl alcohol (PVA), poly-vinylpyrrolidone (PVP) and GO, which was electrochemically reduced to obtain PVA/PVP/RGO/SPCE. The interactions and morphology of the PVA/PVP/GO nanocomposite were investigated by SEM, FTIR and UV-Vis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00399140183122
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http://dx.doi.org/10.1016/j.talanta.2018.11.070DOI Listing
April 2019
3 Reads

Photo-regulatable DNA isothermal amplification by template-mediated ligation.

Chem Commun (Camb) 2019 Jan 8;55(8):1080-1083. Epub 2019 Jan 8.

Department of Bio molecular Engineering, Graduate School of Engineering, Nagoya University Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.

By combining azobenzene-tethered oligonucleotides as modulators and poly(l-lysine)-graft-dextran (PLL-g-Dex), a chaperone polymer, to facilitate strand displacement, we successfully developed a photo-regulatable DNA isothermal amplification method. By alternating UV and visible irradiation, linear amplification was achieved. The method enables photo-regulatability and mismatch discrimination in linear amplification of the DNA target. Read More

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http://dx.doi.org/10.1039/c8cc09218dDOI Listing
January 2019

Cannabinoid concentrations in confiscated cannabis samples and in whole blood and urine after smoking CBD-rich cannabis as a "tobacco substitute".

Int J Legal Med 2019 Jan 5. Epub 2019 Jan 5.

Institute of Forensic Medicine, Department of Traffic Sciences, University of Bern, Sulgenauweg 40, 3007, Bern, Switzerland.

In Switzerland, only cannabis with a total Δ-tetrahydrocannabinol (THC) content higher than 1% is controlled by the narcotics legislation. Cannabis products rich in cannabidiol (CBD) and low in THC can be legally sold as tobacco substitutes. In this paper, we address analytical and forensic toxicological issues related to the increasing availability and consumption of these products. Read More

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http://link.springer.com/10.1007/s00414-018-01994-y
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http://dx.doi.org/10.1007/s00414-018-01994-yDOI Listing
January 2019
5 Reads

Wall porosity in isolated cells from food plants: Implications for nutritional functionality.

Food Chem 2019 May 12;279:416-425. Epub 2018 Dec 12.

ARC Centre of Excellence in Plant Cell Walls, Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072, Australia. Electronic address:

Macronutrients in whole plant foods are enclosed inside cells. The metabolic response from these entrapped nutrients may depend on cell-wall porosity, by controlling the passage of digestive enzymes. As non-interacting size mimics of digestive enzymes, we investigated the diffusion of fluorescently-labelled probes across the walls of isolated plant cells from potato tuber, red kidney bean and banana. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.12.024DOI Listing
May 2019
1 Read

Iron gall ink revisited: hierarchical formation of Fe(iii)-tannic acid coacervate particles in microdroplets for protein condensation.

Chem Commun (Camb) 2019 Feb;55(15):2142-2145

Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon 34141, Korea.

Inspiration from the iron gall ink leads to the efficient formation of Fe(iii)-tannic acid coacervate particles inside the phase-separated microdroplets that are derived from the aqueous PEG/dextran liquid-liquid phase separation system. This hierarchical self-assembly, in aid of the protein affinity of tannic acid, makes it possible to compartmentalize and condense proteins into a localized, compact space in the microdroplets. Read More

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http://dx.doi.org/10.1039/c8cc09507hDOI Listing
February 2019
1 Read

Synthesis and biophysical characteristics of riboflavin/HSA protein system on silver nanoparticles.

Mater Sci Eng C Mater Biol Appl 2019 Mar 30;96:30-40. Epub 2018 Oct 30.

Department of Cellular and Molecular Biology, National Institute of R&D for Biological Sciences, Splaiul Independentei 296, 060031 Bucharest, Romania.

Novel l‑Arginine‑Dextran70 based-silver nanoparticles (SNPs) (SNPs), functionalized with Riboflavin (RF) and Human Serum Albumin (HSA) were characterized by UV-Vis absorption, Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), fluorescence and circular dichroism spectroscopy, chemiluminescence and Neutral red assays. TEM analysis showed the formed faceted particles, large clumps/fused aggregates, nano-featured with the mean particle size of 41.60 nm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183012
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http://dx.doi.org/10.1016/j.msec.2018.10.087DOI Listing
March 2019
9 Reads

A Combined Utilization of Plasdone-S630 and HPMCAS-HF in Ziprasidone Hydrochloride Solid Dispersion by Hot-Melt Extrusion to Enhance the Oral Bioavailability and No Food Effect.

AAPS PharmSciTech 2019 Jan 2;20(1):37. Epub 2019 Jan 2.

Nanjing Tech University, Nanjing, Jiangsu Province, China.

The purpose of this study was to research a novel combination of Plasdone-S630 and HPMCAS-HF as hot-melt carrier used in ziprasidone hydrochloride for enhanced oral bioavailability and dismissed food effect. Ziprasidone hydrochloride solid dispersion (ZH-SD) was prepared by hot-melt extrusion technique, and its optimized formulation was selected by the central composite design (CCD), which was characterized for powder X-ray diffraction (PXRD), fourier transform infrared spectroscopy (FTIR), in vitro dissolution study, and stability study. Finally, the in vivo study in fasted/fed state was carried out in beagle dogs. Read More

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http://dx.doi.org/10.1208/s12249-018-1216-8DOI Listing
January 2019
1 Read

PVP-templated highly luminescent copper nanoclusters for sensing trinitrophenol and living cell imaging.

Nanoscale 2019 Jan;11(3):1286-1294

Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.

Copper nanoclusters (CuNCs) exhibit susceptibility to oxidation in the subnanometer size range. In this work, a facile and green protocol is reported for the successful synthesis of water soluble CuNCs, with poly(vinylpyrrolidone) as a template and ascorbic acid as a mild reducing agent. The as-prepared CuNCs exhibit a green fluorescence and high quantum yield (QY = 44. Read More

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http://dx.doi.org/10.1039/c8nr07142jDOI Listing
January 2019
1 Read

Extraction and characterization of dextran from Leuconostoc pseudomesenteroides YB-2 isolated from mango juice.

Carbohydr Polym 2019 Mar 29;207:218-223. Epub 2018 Nov 29.

Youjiang Medical University for Nationalities, Guangxi, Baise, 533000, PR China; Key Laboratory of Guangxi's College for the Study of Characteristic Medicine in Youjiang River Basin, Youjiang Medical University for Nationalities, Guangxi, Baise, 533000, PR China. Electronic address:

An exopolysaccharide (EPS)-producing strain of YB-2 isolated from mango juice was identified as Leuconostoc pseudomesenteroides. The molecular weight (Mw) of this EPS was 7.67×10 Da. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01448617183142
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http://dx.doi.org/10.1016/j.carbpol.2018.11.092DOI Listing
March 2019
10 Reads

Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings.

Environ Pollut 2019 Mar 13;246:414-422. Epub 2018 Dec 13.

MOE Key Laboratory of Resources and Environmental Systems Optimization, College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, PR China.

Silver nanoparticles (AgNPs) in aquatic ecosystems are toxic to aquatic organisms. In this study, we aimed to investigate the toxicities and molecular mechanisms of AgNPs with different surface coatings (sodium citrate and polyvinylpyrrolidone) and particle sizes (20 nm and 100 nm) in the gills, intestines, and muscles of zebrafish after 96 h of exposure. Our results indicated that the contribution of particle size to AgNP toxicity was greater than that of the surface coating. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.12.034DOI Listing

Pegylated Bovine Carboxyhemoglobin (SANGUINATE) in a Jehovah's Witness Undergoing Liver Transplant: A Case Report.

Transplant Proc 2018 Dec 8;50(10):4012-4014. Epub 2018 Sep 8.

Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

Liver transplantation in practicing Jehovah's Witnesses is challenging because of their religious beliefs preventing them from accepting allogenic blood products. Pegylated bovine carboxyhemoglobin (SANGUINATE) is an oxygen transfer agent, currently under investigation for the treatment of sickle cell disease, which may play a role in these patients by maximizing perioperative oxygen delivery. We report a case involving the use of SANGUINATE in a Jehovah's Witness undergoing liver transplant. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.09.006DOI Listing
December 2018
1 Read

How Synthetic Biology and Metabolic Engineering Can Boost the Generation of Artificial Blood Using Microbial Production Hosts.

Front Bioeng Biotechnol 2018 30;6:186. Epub 2018 Nov 30.

Section of Synthetic Biology, Department of Biotechnology and Biomedicine Technical University of Denmark (DTU), Lyngby, Denmark.

Hemoglobin is an essential protein to the human body as it transports oxygen to organs and tissues through the bloodstream (Looker et al., 1992). In recent years, there has been an increasing concern regarding the global supply of this vital protein, as blood availability cannot currently meet the high demands in many developing countries. Read More

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http://dx.doi.org/10.3389/fbioe.2018.00186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287201PMC
November 2018
4 Reads

Successful Use of Negative-pressure Wound Therapy and Dermal Substitute in the Treatment of Gluteal Ecthyma Gangrenosum in a 2-year-old Girl.

Plast Reconstr Surg Glob Open 2018 Oct 3;6(10):e1953. Epub 2018 Oct 3.

Department of Pediatric Surgery, Meyer Children Hospital, Florence, Italy.

Ecthyma Gangrenosum is a manifestation of infection, usually occurring in immunocompromised patients, which can be associated with bacteremia with potentially lethal outcome. The clinical appearance is of an inflammatory cutaneous lesion with a central necrotic spot; the lesion then rapidly progresses to a gangrenous ulcer with a gray-black eschar extending in the deep soft tissues. Treatment of Ecthyma Gangrenosum includes both aggressive systemic antibiotic therapy and surgical procedures. Read More

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http://Insights.ovid.com/crossref?an=01720096-201810000-0003
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http://dx.doi.org/10.1097/GOX.0000000000001953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250464PMC
October 2018
7 Reads

The effect of silver nanoparticles and silver ions on zebrafish embryos (Danio rerio).

Neuro Endocrinol Lett 2018 Oct;39(4):299-304

Department of Animal Protection, Welfare and Behaviour, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.

Objectives: The aim of this study was to establish and evaluate the mortality rate, hatching rate and observe the presence of sublethal changes in zebrafish embryos after exposure to silver ions and nanoparticles.

Methods: Tests were conducted on newly fertilized zebrafish embryos, according to the modified OECD guideline 236, using a semistatic method and 96 hour incubation time. Silver nitrate and two different silver nanoparticles, stabilized with 0. Read More

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October 2018
4 Reads

Molecular epidemiology of HIV-1 infection among men who have sex with men in Taiwan from 2013 to 2015.

PLoS One 2018 6;13(12):e0202622. Epub 2018 Dec 6.

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.

Men who have sex with men (MSM) is the major risk population of HIV-1 infection in Taiwan, and its surveillance has become critical in HIV-1 prevention. We recruited MSM subjects from 17 high-risk venues and 4 community centers in northern and southern Taiwan for anonymous HIV-1 screening during 2013-2015. Blood samples were obtained for genotyping and phylogenetic analysis, and a questionnaire survey covering demographic variables and social behavior was conducted. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202622PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283607PMC
December 2018
9 Reads

The surrounding tissue contributes to smooth muscle cells' regeneration and vascularization of small diameter vascular grafts.

Biomater Sci 2019 Feb;7(3):914-925

Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.

Small diameter vascular grafts have been promising substitutes for bypass surgery to treat cardiovascular disease. However, no ideal product is available in the clinic. In order to design improved, next generation vascular grafts, it is essential to understand the cellular and molecular mechanisms underlying tissue regeneration after vascular graft implantation. Read More

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http://dx.doi.org/10.1039/c8bm01277fDOI Listing
February 2019
3 Reads

The impact of immune response on endochondral bone regeneration.

NPJ Regen Med 2018 29;3:22. Epub 2018 Nov 29.

1Department of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, Utrecht University, Utrecht, G05.222, PO Box 85500, 3508 GA The Netherlands.

Tissue engineered cartilage substitutes, which induce the process of endochondral ossification, represent a regenerative strategy for bone defect healing. Such constructs typically consist of multipotent mesenchymal stromal cells (MSCs) forming a cartilage template in vitro, which can be implanted to stimulate bone formation in vivo. The use of MSCs of allogeneic origin could potentially improve the clinical utility of the tissue engineered cartilage constructs in three ways. Read More

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http://www.nature.com/articles/s41536-018-0060-5
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http://dx.doi.org/10.1038/s41536-018-0060-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265275PMC
November 2018
12 Reads

Biomarkers in traumatic brain injury (TBI): a review.

Neuropsychiatr Dis Treat 2018 8;14:2989-3000. Epub 2018 Nov 8.

FloTBI Inc., Cleveland, OH, USA,

Biomarkers can be broadly defined as qualitative or quantitative measurements that convey information on the physiopathological state of a subject at a certain time point or disease state. Biomarkers can indicate health, pathology, or response to treatment, including unwanted side effects. When used as outcomes in clinical trials, biomarkers act as surrogates or substitutes for clinically meaningful endpoints. Read More

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https://www.dovepress.com/biomarkers-in-traumatic-brain-inju
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http://dx.doi.org/10.2147/NDT.S125620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231511PMC
November 2018
12 Reads

Cell Seeding on UV-C-Treated 3D Polymeric Templates Allows for Cost-Effective Production of Small-Caliber Tissue-Engineered Blood Vessels.

Biotechnol J 2019 Jan 21;14(1):e1800306. Epub 2018 Dec 21.

Laval University Experimental Organogenesis Research Center/LOEX, Division of Regenerative Medicine, CHU de Québec Research Center, Enfant-Jésus Hospital, 1401, 18e rue, Québec, G1J 1Z4, Canada.

There is a strong clinical need to develop small-caliber tissue-engineered blood vessels for arterial bypass surgeries. Such substitutes can be engineered using the self-assembly approach in which cells produce their own extracellular matrix (ECM), creating a robust vessel without exogenous material. However, this approach is currently limited to the production of flat sheets that need to be further rolled into the final desired tubular shape. Read More

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http://dx.doi.org/10.1002/biot.201800306DOI Listing
January 2019
1 Read

Oxidant Potential of Krunidon In Vitro and In Vivo.

Bull Exp Biol Med 2018 Dec 28;166(2):213-216. Epub 2018 Nov 28.

Research Center "Park of Active Molecules", Obninsk, Russia.

We studied the effect of Fe ions in polymerized hemoglobin (Krunidon blood substitute) and in molecular hemoglobin (Sigma) on OH radical initiation in the Fenton system. It was found that polymerized hemoglobin, as a component of Krunidon preparation, in contrast to hemoglobin tetramer, did not intensify OH radical generation. The oxidant potential of Krunidon was evaluated in vivo by measuring malondialdehyde level in dog blood plasma after repeated intravenous administration (5 days in a dose of 114 mg/kg) as a biomarker. Read More

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http://dx.doi.org/10.1007/s10517-018-4316-2DOI Listing
December 2018
1 Read

An intensive milk replacer feeding program benefits immune response and intestinal microbiota of lambs during weaning.

BMC Vet Res 2018 Nov 26;14(1):366. Epub 2018 Nov 26.

State Key Laboratory of Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.

Background: Pre-weaning milk replacer (MR) feeding program is a key factor affecting the health and welfare of lambs during their weaning. Weaning stress is well known as an inducement that negatively impacts the immune system of young ruminants, whose physiological and immune state is closely linked to the community of microbiota in their intestines. This study had two objectives: 1) To evaluate the innate immune response to weaning stress at both the physiological and molecular level; 2) To investigate changes to the jejunal chyme and mucosal adhesive microbiota between the control and high plane of MR groups. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1691-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258415PMC
November 2018
14 Reads

Characterization of a tissue-engineered choroid.

Acta Biomater 2019 Jan 23;84:305-316. Epub 2018 Nov 23.

Département d'ophtalmologie et d'ORL-CCF, Faculté de médecine, Université Laval, Québec, QC, Canada; Centre de recherche du CHU de Québec-UL, Axe médecine régénératrice, Québec, QC, Canada; Centre de recherche en organogénèse expérimentale de l'Université Laval/LOEX, Québec, QC, Canada. Electronic address:

The choroid of the eye is a vascularized and pigmented connective tissue lying between the retina and the sclera. Increasing evidence demonstrates that, beyond supplying nutrients to the outer retina, the different choroidal cells contribute to the retina's homeostasis, especially by paracrine signaling. However, the precise role of each cell type is currently unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183069
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http://dx.doi.org/10.1016/j.actbio.2018.11.033DOI Listing
January 2019
15 Reads

Invited commentary.

Authors:
Shirling Tsai

J Vasc Surg 2018 12;68(6S):187S

Dallas, Tex.

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http://dx.doi.org/10.1016/j.jvs.2017.10.058DOI Listing
December 2018
1 Read

Dietary exposure of mussels to PVP/PEI coated Ag nanoparticles causes Ag accumulation in adults and abnormal embryo development in their offspring.

Sci Total Environ 2019 Mar 14;655:48-60. Epub 2018 Nov 14.

CBET Research Group, Dept. Zoology and Animal Cell Biology, Faculty of Science and Technology and Research Centre for Experimental Marine Biology and Biotechnology PiE, University of the Basque Country UPV/EHU, Basque Country, Spain. Electronic address:

Toxicity of silver nanoparticles (Ag NPs) to aquatic organisms has been widely studied. However, the potential toxic effects of Ag NPs ingested through the food web, especially at environmentally relevant concentrations, as well as the potential effects on the offspring remain unknown. The aims of this work were to screen the cytotoxicity of Poly N‑vinyl‑2‑pirrolidone/Polyethyleneimine (PVP/PEI) coated 5 nm Ag NPs in hemocytes exposed in vitro and to assess the effects of dietary exposure to Ag NPs on mussels growth, immune status, gonad condition, reproductive success and offspring embryo development. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.181DOI Listing
March 2019
1 Read

Injection of Urethral Bulking Agents.

Urol Clin North Am 2019 Feb;46(1):1-15

Urinary Tract and Pelvic Reconstruction, Department of Urology, MD Anderson Cancer Center, Unit 1373, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

Urethral injection is a safe and minimally invasive method of treating female stress urinary incontinence with multiple bulking agents currently commercially available. Although there are numerous studies that demonstrate efficacy, long-term success is not yet proven. This article aims to describe the mechanism of action and properties of various agents, patient selection factors, available techniques for injection, outcomes of urethral injections, and complications associated with the procedure. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.08.012DOI Listing
February 2019
20 Reads

Clinical and CT Analysis of Lumbar Spine Arthrodesis: β-Tricalcium Phosphate Versus Demineralized Bone Matrix.

J Am Acad Orthop Surg Glob Res Rev 2018 Sep 12;2(9):e024. Epub 2018 Sep 12.

Department of Orthopaedics, Beaumont Health System, Royal Oak, MI.

Background: Bone graft substitutes have been developed to circumvent donor site morbidity associated with iliac crest bone graft, but sparse literature compares the efficacy of various substitutes. Two commonly used bone graft substitutes used in lumbar fusion are β-tricalcium phosphate (BTP) and demineralized bone matrix (DBM).

Methods: A retrospective review of patients who underwent instrumented posterolateral lumbar fusion was conducted by a single surgeon from January 2013 to December 2016. Read More

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http://dx.doi.org/10.5435/JAAOSGlobal-D-18-00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226294PMC
September 2018
27 Reads

The synthesis of a new macromolecule for the sentinel node detection: 99mTc-gly-mannosyl-dextran.

Nucl Med Commun 2019 Feb;40(2):131-135

Key Laboratory of Nuclear Medicine, Ministry of Health, Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China.

Objective: We aimed to design and synthesize a new macromolecule for sentinel node detection to improve the imaging quality and avoid possible adverse effect.

Background: The imaging of sentinel lymph node has been an important field in the nuclear medicine. A lot of imaging agents have been developed, including Tc-sulfer colloid, Tc-labeled dextrans and the latest Tc-DTPA-mannosyl-dextran. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000951DOI Listing
February 2019
25 Reads

Effects of sodium chloride and sodium perchlorate on properties and partition behavior of solutes in aqueous dextran-polyethylene glycol and polyethylene glycol-sodium sulfate two-phase systems.

J Chromatogr A 2019 Jan 12;1583:28-38. Epub 2018 Nov 12.

IBB-Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal. Electronic address:

Effects of two salt additives, NaCl and NaClO, at the fixed concentrations of 0.215 M on the properties of aqueous two-phase systems (ATPSs) formed by dextran (Dex) and polyethylene glycol (PEG), and the effects of NaClO at the same concentration on the properties of ATPS formed by PEG and NaSO were examined. The effects of these salt additives on partitioning of 12 small organic compounds and five proteins in the above ATPSs were studied. Read More

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http://dx.doi.org/10.1016/j.chroma.2018.11.015DOI Listing
January 2019
11 Reads