43,443 results match your criteria Blood Substitutes


Cannabinoid concentrations in confiscated cannabis samples and in whole blood and urine after smoking CBD-rich cannabis as a "tobacco substitute".

Int J Legal Med 2019 Jan 5. Epub 2019 Jan 5.

Institute of Forensic Medicine, Department of Traffic Sciences, University of Bern, Sulgenauweg 40, 3007, Bern, Switzerland.

In Switzerland, only cannabis with a total Δ-tetrahydrocannabinol (THC) content higher than 1% is controlled by the narcotics legislation. Cannabis products rich in cannabidiol (CBD) and low in THC can be legally sold as tobacco substitutes. In this paper, we address analytical and forensic toxicological issues related to the increasing availability and consumption of these products. Read More

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http://dx.doi.org/10.1007/s00414-018-01994-yDOI Listing
January 2019
1 Read

How Synthetic Biology and Metabolic Engineering Can Boost the Generation of Artificial Blood Using Microbial Production Hosts.

Front Bioeng Biotechnol 2018 30;6:186. Epub 2018 Nov 30.

Section of Synthetic Biology, Department of Biotechnology and Biomedicine Technical University of Denmark (DTU), Lyngby, Denmark.

Hemoglobin is an essential protein to the human body as it transports oxygen to organs and tissues through the bloodstream (Looker et al., 1992). In recent years, there has been an increasing concern regarding the global supply of this vital protein, as blood availability cannot currently meet the high demands in many developing countries. Read More

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http://dx.doi.org/10.3389/fbioe.2018.00186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287201PMC
November 2018
2 Reads

Successful Use of Negative-pressure Wound Therapy and Dermal Substitute in the Treatment of Gluteal Ecthyma Gangrenosum in a 2-year-old Girl.

Plast Reconstr Surg Glob Open 2018 Oct 3;6(10):e1953. Epub 2018 Oct 3.

Department of Pediatric Surgery, Meyer Children Hospital, Florence, Italy.

Ecthyma Gangrenosum is a manifestation of infection, usually occurring in immunocompromised patients, which can be associated with bacteremia with potentially lethal outcome. The clinical appearance is of an inflammatory cutaneous lesion with a central necrotic spot; the lesion then rapidly progresses to a gangrenous ulcer with a gray-black eschar extending in the deep soft tissues. Treatment of Ecthyma Gangrenosum includes both aggressive systemic antibiotic therapy and surgical procedures. Read More

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http://Insights.ovid.com/crossref?an=01720096-201810000-0003
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http://dx.doi.org/10.1097/GOX.0000000000001953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250464PMC
October 2018
3 Reads

Molecular epidemiology of HIV-1 infection among men who have sex with men in Taiwan from 2013 to 2015.

PLoS One 2018 6;13(12):e0202622. Epub 2018 Dec 6.

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.

Men who have sex with men (MSM) is the major risk population of HIV-1 infection in Taiwan, and its surveillance has become critical in HIV-1 prevention. We recruited MSM subjects from 17 high-risk venues and 4 community centers in northern and southern Taiwan for anonymous HIV-1 screening during 2013-2015. Blood samples were obtained for genotyping and phylogenetic analysis, and a questionnaire survey covering demographic variables and social behavior was conducted. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202622PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283607PMC
December 2018
3 Reads

The surrounding tissue contributes to smooth muscle cells' regeneration and vascularization of small diameter vascular grafts.

Biomater Sci 2018 Dec 4. Epub 2018 Dec 4.

Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China. and Key Laboratory of Bioactive Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Science, Nankai University, Tianjin 300071, China.

Small diameter vascular grafts have been promising substitutes for bypass surgery to treat cardiovascular disease. However, no ideal product is available in the clinic. In order to design improved, next generation vascular grafts, it is essential to understand the cellular and molecular mechanisms underlying tissue regeneration after vascular graft implantation. Read More

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http://dx.doi.org/10.1039/c8bm01277fDOI Listing
December 2018
2 Reads

The impact of immune response on endochondral bone regeneration.

NPJ Regen Med 2018 29;3:22. Epub 2018 Nov 29.

1Department of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, Utrecht University, Utrecht, G05.222, PO Box 85500, 3508 GA The Netherlands.

Tissue engineered cartilage substitutes, which induce the process of endochondral ossification, represent a regenerative strategy for bone defect healing. Such constructs typically consist of multipotent mesenchymal stromal cells (MSCs) forming a cartilage template in vitro, which can be implanted to stimulate bone formation in vivo. The use of MSCs of allogeneic origin could potentially improve the clinical utility of the tissue engineered cartilage constructs in three ways. Read More

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http://www.nature.com/articles/s41536-018-0060-5
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http://dx.doi.org/10.1038/s41536-018-0060-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265275PMC
November 2018
6 Reads

Biomarkers in traumatic brain injury (TBI): a review.

Neuropsychiatr Dis Treat 2018 8;14:2989-3000. Epub 2018 Nov 8.

FloTBI Inc., Cleveland, OH, USA,

Biomarkers can be broadly defined as qualitative or quantitative measurements that convey information on the physiopathological state of a subject at a certain time point or disease state. Biomarkers can indicate health, pathology, or response to treatment, including unwanted side effects. When used as outcomes in clinical trials, biomarkers act as surrogates or substitutes for clinically meaningful endpoints. Read More

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https://www.dovepress.com/biomarkers-in-traumatic-brain-inju
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http://dx.doi.org/10.2147/NDT.S125620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231511PMC
November 2018
4 Reads

Cell Seeding on UV-C-Treated 3D Polymeric Templates Allows for Cost-Effective Production of Small-Caliber Tissue-Engineered Blood Vessels.

Biotechnol J 2019 Jan 21;14(1):e1800306. Epub 2018 Dec 21.

Laval University Experimental Organogenesis Research Center/LOEX, Division of Regenerative Medicine, CHU de Québec Research Center, Enfant-Jésus Hospital, 1401, 18e rue, Québec, G1J 1Z4, Canada.

There is a strong clinical need to develop small-caliber tissue-engineered blood vessels for arterial bypass surgeries. Such substitutes can be engineered using the self-assembly approach in which cells produce their own extracellular matrix (ECM), creating a robust vessel without exogenous material. However, this approach is currently limited to the production of flat sheets that need to be further rolled into the final desired tubular shape. Read More

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http://dx.doi.org/10.1002/biot.201800306DOI Listing
January 2019

Oxidant Potential of Krunidon In Vitro and In Vivo.

Bull Exp Biol Med 2018 Dec 28;166(2):213-216. Epub 2018 Nov 28.

Research Center "Park of Active Molecules", Obninsk, Russia.

We studied the effect of Fe ions in polymerized hemoglobin (Krunidon blood substitute) and in molecular hemoglobin (Sigma) on OH radical initiation in the Fenton system. It was found that polymerized hemoglobin, as a component of Krunidon preparation, in contrast to hemoglobin tetramer, did not intensify OH radical generation. The oxidant potential of Krunidon was evaluated in vivo by measuring malondialdehyde level in dog blood plasma after repeated intravenous administration (5 days in a dose of 114 mg/kg) as a biomarker. Read More

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http://dx.doi.org/10.1007/s10517-018-4316-2DOI Listing
December 2018

An intensive milk replacer feeding program benefits immune response and intestinal microbiota of lambs during weaning.

BMC Vet Res 2018 Nov 26;14(1):366. Epub 2018 Nov 26.

State Key Laboratory of Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China.

Background: Pre-weaning milk replacer (MR) feeding program is a key factor affecting the health and welfare of lambs during their weaning. Weaning stress is well known as an inducement that negatively impacts the immune system of young ruminants, whose physiological and immune state is closely linked to the community of microbiota in their intestines. This study had two objectives: 1) To evaluate the innate immune response to weaning stress at both the physiological and molecular level; 2) To investigate changes to the jejunal chyme and mucosal adhesive microbiota between the control and high plane of MR groups. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1691-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258415PMC
November 2018
5 Reads

Characterization of a tissue-engineered choroid.

Acta Biomater 2019 Jan 23;84:305-316. Epub 2018 Nov 23.

Département d'ophtalmologie et d'ORL-CCF, Faculté de médecine, Université Laval, Québec, QC, Canada; Centre de recherche du CHU de Québec-UL, Axe médecine régénératrice, Québec, QC, Canada; Centre de recherche en organogénèse expérimentale de l'Université Laval/LOEX, Québec, QC, Canada. Electronic address:

The choroid of the eye is a vascularized and pigmented connective tissue lying between the retina and the sclera. Increasing evidence demonstrates that, beyond supplying nutrients to the outer retina, the different choroidal cells contribute to the retina's homeostasis, especially by paracrine signaling. However, the precise role of each cell type is currently unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183069
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http://dx.doi.org/10.1016/j.actbio.2018.11.033DOI Listing
January 2019
11 Reads

Injection of Urethral Bulking Agents.

Urol Clin North Am 2019 Feb;46(1):1-15

Urinary Tract and Pelvic Reconstruction, Department of Urology, MD Anderson Cancer Center, Unit 1373, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

Urethral injection is a safe and minimally invasive method of treating female stress urinary incontinence with multiple bulking agents currently commercially available. Although there are numerous studies that demonstrate efficacy, long-term success is not yet proven. This article aims to describe the mechanism of action and properties of various agents, patient selection factors, available techniques for injection, outcomes of urethral injections, and complications associated with the procedure. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.08.012DOI Listing
February 2019
4 Reads

Clinical and CT Analysis of Lumbar Spine Arthrodesis: β-Tricalcium Phosphate Versus Demineralized Bone Matrix.

J Am Acad Orthop Surg Glob Res Rev 2018 Sep 12;2(9):e024. Epub 2018 Sep 12.

Department of Orthopaedics, Beaumont Health System, Royal Oak, MI.

Background: Bone graft substitutes have been developed to circumvent donor site morbidity associated with iliac crest bone graft, but sparse literature compares the efficacy of various substitutes. Two commonly used bone graft substitutes used in lumbar fusion are β-tricalcium phosphate (BTP) and demineralized bone matrix (DBM).

Methods: A retrospective review of patients who underwent instrumented posterolateral lumbar fusion was conducted by a single surgeon from January 2013 to December 2016. Read More

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http://dx.doi.org/10.5435/JAAOSGlobal-D-18-00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226294PMC
September 2018
16 Reads

Glycopolymers/PEI complexes as serum-tolerant vectors for enhanced gene delivery to hepatocytes.

Carbohydr Polym 2019 Feb 15;205:167-175. Epub 2018 Oct 15.

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, PR China. Electronic address:

Serum stability is a crucial factor for ideal polymeric gene vectors. In this work, a series of serum-tolerant and low-toxicity glycopolymers/poly(ethyleneimine) (PEI) complexes were designed for gene delivery. Atomic transfer radical polymerization (ATRP) was used to synthesize the comb-shaped random copolymers dextran-g-poly(2-dimethylaminoethyl methacrylate-co-2-lactobionamidoethyl methacrylate) (DDrL). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01448617183122
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http://dx.doi.org/10.1016/j.carbpol.2018.10.036DOI Listing
February 2019
8 Reads

Cannabinoid-like effects of five novel carboxamide synthetic cannabinoids.

Neurotoxicology 2018 Nov 12;70:72-79. Epub 2018 Nov 12.

Department of Pharmacology and Neuroscience, Center for Neuroscience Discovery, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA.

A new generation of novel cannabinoid compounds have been developed as marijuana substitutes to avoid drug control laws and cannabinoid blood tests. 5F-MDMB-PINACA (also known as 5F-ADB, 5F-ADB-PINACA), MDMB-CHIMICA, MDMB-FUBINACA, ADB-FUBINACA, and AMB-FUBINACA (also known as FUB-AMB, MMB-FUBINACA) were tested for in vivo cannabinoid-like effects to assess their abuse liability. Locomotor activity in mice was tested to screen for locomotor depressant effects and to identify behaviorally-active dose ranges and times of peak effect. Read More

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http://dx.doi.org/10.1016/j.neuro.2018.11.004DOI Listing
November 2018
2 Reads

Induction of angiogenic and inflammation-associated dermal biomarkers following acute UVB exposure on bio-engineered pigmented dermo-epidermal skin substitutes in vivo.

Pediatr Surg Int 2019 Jan 14;35(1):129-136. Epub 2018 Nov 14.

Tissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland.

Purpose: Ultraviolet (UV) radiation adversely affects skin health at cellular and molecular levels. Hence, UV radiation can directly induce inflammatory responses in the dermis by inducing erythema, edema, inflammation, dermal fibroblasts alterations, and extracellular matrix modifications.

Methods: Human keratinocytes, melanocytes, and fibroblasts were isolated from skin biopsies, cultured, and expanded in vitro. Read More

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http://link.springer.com/10.1007/s00383-018-4384-4
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http://dx.doi.org/10.1007/s00383-018-4384-4DOI Listing
January 2019
9 Reads

Effects of partial replacement of soybean meal with other protein sources in diets of lactating cows.

Animal 2018 Nov 12:1-9. Epub 2018 Nov 12.

1Faculdade de Zootecnia e Engenharia de Alimentos,Universidade de São Paulo,13635900, Pirassununga, São Paulo,Brazil.

The protein nutrition of dairy cows is of great importance because of its direct influence on milk production, reproductive efficiency, and feeding cost. Eight first-lactation Holstein cows were randomly assigned to two contemporary 4 × 4 Latin squares in a 2 × 2 factorial design to evaluate the effects of replacing soybean meal with yeast-derived microbial protein (YMP) as a protein source (0% or 1.5% of dry matter (DM)) and its combination with slow-release urea (SRU; 0% or 0. Read More

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http://dx.doi.org/10.1017/S1751731118002926DOI Listing
November 2018

Polymeric nanoparticles promote endocytosis of a survivin molecular beacon: Localization and fate of nanoparticles and beacon in human A549 cells.

Life Sci 2018 Dec 7;215:106-112. Epub 2018 Nov 7.

Istituto di Fisica Applicata "Nello Carrara", Consiglio Nazionale delle Ricerche, Via Madonna del Piano 10, 50019 Sesto Fiorentino, FI, Italy. Electronic address:

Polymethylmethacrylate core-shell fluorescent nanoparticles promote, in human lung A549 cancer cells, the internalization of a molecular beacon (MB) specific for survivin mRNA, an anti-apoptotic protein overexpressed in cancer cells.

Aims: To design an effective drug delivery system, the knowledge of the uptake mechanism and of the nanoparticles (NPs) and MB fate is required.

Materials And Methods And Key Findings: Experiments with dextran as marker for endocytosis showed that in the presence of NPs the number of endocytic vesicles per cell doubled and their mean size significantly (p < 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183071
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http://dx.doi.org/10.1016/j.lfs.2018.11.007DOI Listing
December 2018
8 Reads

Perfluoroalkane sulfonyl fluorides non-covalently bind to human serum albumin at Sudlow's sites.

Toxicol Lett 2019 Feb 5;301:17-23. Epub 2018 Nov 5.

College of Pharmaceutical Sciences, Zhejiang University, Zhejiang 310058, China. Electronic address:

Perfluorooctane sulfonyl fluoride (PFOSF) has been defined as persistent organic pollutant in the Stockholm Convention in 2009. Currently PFOSF and its substitutes (structural analogues in which octyl group is substituted for other aliphatic chains) are still scarcely studied. HSA is a main carrier for drugs in blood, and the influence of exogenous compounds including pollutants on HSA is of particular interest. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.11.001DOI Listing
February 2019
6 Reads

The Buoyancy of Is Affected by Capsule Size.

mSphere 2018 11 7;3(6). Epub 2018 Nov 7.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

is an environmental pathogenic fungus with a worldwide geographical distribution that is responsible for hundreds of thousands of human cryptococcosis cases each year. During infection, the yeast undergoes a morphological transformation involving capsular enlargement that increases microbial volume. To understand the factors that play a role in environmental dispersal of and , we evaluated the cell density of using Percoll isopycnic gradients. Read More

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http://dx.doi.org/10.1128/mSphere.00534-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222054PMC
November 2018
1 Read

Size- and shape-dependent toxicity of silver nanomaterials in green alga Chlorococcum infusionum.

Ecotoxicol Environ Saf 2019 Jan 2;168:388-393. Epub 2018 Nov 2.

Department of Environmental Health Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea. Electronic address:

Silver nanomaterials (AgNMs) of different shapes and sizes are potentially toxic to aquatic organisms. However, studies on the toxicity of AgNMs and on their shape-dependent effects on algae are scarce. The present study evaluated the effects of three AgNMs (silver nanospheres, AgNPs; silver nanowires, AgNWs; silver nanoplates, AgPLs) with different shapes coated with polyvinylpyrrolidone on the growth and photosynthetic performance of an alga, Chlorococcum infusionum. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.10.082DOI Listing
January 2019
2 Reads

The feasibility of finger prick autologous blood (FAB) as a novel treatment for severe dry eye disease (DED): protocol for a randomised controlled trial.

BMJ Open 2018 Oct 31;8(10):e026770. Epub 2018 Oct 31.

Bedford Hospital NHS Trust, Bedford, UK.

Introduction: Patients with severe dry eye disease (DED) often have limited treatment options with standard non-surgical management focused on the use of artificial tears for lubrication and anti-inflammatory drugs. However, artificial tears do not address the extraordinary complexity of human tears. Crudely, human tears with its vast constituents is essentially filtered blood. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02677
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http://dx.doi.org/10.1136/bmjopen-2018-026770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252631PMC
October 2018
5 Reads

[Safety Evaluation of Cellular-type Artificial Blood Based on Pharmacokinetic Analysis and Its Use in Medical Gas Delivery].

Authors:
Kazuaki Taguchi

Yakugaku Zasshi 2018 ;138(11):1381-1389

Faculty of Pharmaceutical Sciences, Sojo University.

Hemoglobin vesicles (HbVs) in which human hemoglobin is encapsulated in a phospholipid bilayer membrane (liposome) have been developed as artificial red blood cells. Although the effectiveness of HbVs, including their physicochemical characteristics and pharmacological effects, has been reported, data on the pharmacokinetic properties of HbVs are limited. Previously, we developed two kinds of radiolabeled HbV, I-HbV and H-HbV, in which the internal hemoglobin and lipid membranes were labeled with I and H, respectively. Read More

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http://dx.doi.org/10.1248/yakushi.18-00127DOI Listing
November 2018
2 Reads

Soft tissue substitutes to increase gingival thickness: Histologic and volumetric analyses in dogs.

J Clin Periodontol 2018 Oct 29. Epub 2018 Oct 29.

Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.

Objectives: To evaluate the histologic and volumetric changes of gingival tissues following grafting with collagen-based matrices at labial aspect of teeth in canines.

Materials And Methods: Gingival augmentation was performed in the mandibular incisor area using two types of xenogeneic cross-linked collagen matrices (CCMs), bovine CCM for BCCM group and porcine CCM for PCCM group, whereas the contralateral sides remained untreated (B-control group and P-control group). Descriptive histology, histometric and volumetric analyses were performed after 12 weeks. Read More

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http://doi.wiley.com/10.1111/jcpe.13034
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http://dx.doi.org/10.1111/jcpe.13034DOI Listing
October 2018
6 Reads

A scientist's fraudulent studies put patients at risk.

Authors:
Adam Marcus

Science 2018 Oct 25;362(6413):394. Epub 2018 Oct 25.

Retraction Watch.

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http://dx.doi.org/10.1126/science.362.6413.394-aDOI Listing
October 2018

Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs.

J Vet Intern Med 2018 Nov 25;32(6):1927-1933. Epub 2018 Oct 25.

Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.

Background: Tetrastarch solution (TS) can impair coagulation but the clinical relevance of this impairment is unclear in veterinary medicine.

Objective: Compare the effects of volume replacement (VR) with lactated Ringer's solution (LRS) or 6% TS on coagulation in hemorrhaged dogs.

Animals: Six healthy English Pointer dogs (19. Read More

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http://dx.doi.org/10.1111/jvim.15327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272039PMC
November 2018
9 Reads

Extracorporeal Barbotage Detoxification of the Blood Plasma.

Bull Exp Biol Med 2018 Oct 23;165(6):820-822. Epub 2018 Oct 23.

I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.

We studied the efficiency of bubbling air as a method of detoxification of the blood plasma and its mixtures with plasma substitutes from CCl4. The efficiency of detoxification depended on the characteristics of the obtained foams: foam forming ability, frequency rate, dispersion, stability of a foam skeleton, syneresis, etc. A hardware-software complex for extracorporeal blood plasma detoxification was developed and the programs for the control and regulation of this process were tested. Read More

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http://dx.doi.org/10.1007/s10517-018-4273-9DOI Listing
October 2018
1 Read

How to Ward Off Retinal Toxicity of Perfluorooctane and Other Perfluorocarbon Liquids?

Invest Ophthalmol Vis Sci 2018 Oct;59(12):4841-4846

Department of Ophthalmology, University Medical Center, Goettingen, Germany.

Purpose: Reactive and underfluorinated impurities are acknowledged as a source of cytotoxicity of perfluorocarbon liquids (PFCLs) used as blood substitutes. To determine whether this is also a relevant factor in retinal toxicity, we analyzed eight PFO batches associated with adverse ocular events.

Methods: (A) The amount of reactive and underflurinated impurities was analyzed by fluoride-selective potentiometry and expressed as H-value. Read More

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http://dx.doi.org/10.1167/iovs.18-24698DOI Listing
October 2018
2 Reads

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat.

J Vis Exp 2018 Oct 6(140). Epub 2018 Oct 6.

Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, University Hospital Jena;

Organ engineering is a novel strategy to generate liver organ substitutes that can potentially be used in transplantation. Recently, in vivo liver engineering, including in vivo organ decellularization followed by repopulation, has emerged as a promising approach over ex vivo liver engineering. However, postoperative survival was not achieved. Read More

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https://www.jove.com/pdf/57991/a-novel-surgical-technique-as
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https://www.jove.com/video/57991/a-novel-surgical-technique-
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http://dx.doi.org/10.3791/57991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235435PMC
October 2018
6 Reads

Precut DMEK Using Dextran-Containing Storage Medium Is Equivalent to Conventional DMEK: A Prospective Pilot Study.

Cornea 2019 Jan;38(1):24-29

Department of Ophthalmology, Eye Clinic Sulzbach, Knappschaft Hospital Saar, Sulzbach/Saar, Germany.

Purpose: To compare the clinical outcome after Descemet membrane endothelial keratoplasty (DMEK) either as precut or conventional Descemet membrane graft preparation under standard European eye bank organ culture conditions.

Methods: This was a prospective pilot study of patients receiving either precut or conventional DMEK. Graft preparation was performed using the liquid bubble technique. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001778DOI Listing
January 2019
2 Reads

Preemptive volume therapy to prevent hemodynamic changes caused by the beach chair position: hydroxyethyl starch 130/0.4 versus Ringer's acetate-a controlled randomized trial.

J Shoulder Elbow Surg 2018 Dec 12;27(12):2129-2138. Epub 2018 Oct 12.

Clinic of Anesthesiology, Ludwig-Maximilians-University Munich, Munich, Germany. Electronic address:

Background: Hemodynamic instability frequently occurs in beach chair positioning for surgery, putting patients at risk for cerebral adverse events. This study examined whether preoperative volume loading with crystalloids alone or with a crystalloid-colloid combination can prevent hemodynamic changes that may be causative for unfavorable neurologic outcomes.

Methods: The study randomly assigned 43 adult patients undergoing shoulder surgery to 3 study groups. Read More

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http://dx.doi.org/10.1016/j.jse.2018.08.003DOI Listing
December 2018

In situ blood vessel regeneration using neuropeptide substance P-conjugated small-diameter vascular grafts.

J Biomed Mater Res B Appl Biomater 2018 Oct 13. Epub 2018 Oct 13.

Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.

In situ blood vessel regeneration through host stem/progenitor cell mobilization may hold great promise for vascular reconstruction. Neuropeptide substance P (SP) has been shown to accelerate tissue repair by endogenous cell mobilization and recruitment. This study was aimed to evaluate the vascular regeneration potential of SP and heparin co-tethered vascular grafts. Read More

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http://dx.doi.org/10.1002/jbm.b.34260DOI Listing
October 2018
3 Reads
2.760 Impact Factor

Biomimetic Nanoemulsions for Oxygen Delivery In Vivo.

Adv Mater 2018 Dec 8;30(49):e1804693. Epub 2018 Oct 8.

Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093, USA.

Blood transfusion is oftentimes required for patients suffering from acute trauma or undergoing surgical procedures in order to help maintain the body's oxygen levels. The continued demand worldwide for blood products is expected to put significant strain on available resources and infrastructure. Unfortunately, efforts to develop viable alternatives to human red blood cells for transfusion are generally unsuccessful. Read More

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http://doi.wiley.com/10.1002/adma.201804693
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http://dx.doi.org/10.1002/adma.201804693DOI Listing
December 2018
2 Reads

Doxorubicin-loaded dextran-based nano-carriers for highly efficient inhibition of lymphoma cell growth and synchronous reduction of cardiac toxicity.

Int J Nanomedicine 2018 24;13:5673-5683. Epub 2018 Sep 24.

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Purpose: Cardiac side effects of doxorubicin (Dox) have limited its clinical application. The aim of this study was to explore new Dox-loaded dextran-based nano-carriers (NCs) in efficiently targeting tumor growth with less cardiac toxicity.

Methods: Inspired by recent reports that polymeric NCs could function as sustained, controlled and targeted drug delivery systems, we developed Dox-loaded NCs which displayed a 2-fold release ratio of Dox in the mimic tumor site condition (pH 5. Read More

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https://www.dovepress.com/doxorubicin-loaded-dextran-based-n
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http://dx.doi.org/10.2147/IJN.S161203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161723PMC
November 2018
12 Reads

Chemotherapeutic Efficacy of Implantable Antineoplastic-Treatment Protocols in an Optimal Mouse Model for Human Ovarian Carcinoma Cell Targeting.

Int J Mol Sci 2018 Oct 4;19(10). Epub 2018 Oct 4.

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, Faculty of Health Sciences, School of Therapeutics Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.

The present study aimed to design and develop a nanocomposite drug delivery system employing an antineoplastic-loaded antibody functionalized nanomicelle encapsulated within a Chitosan⁻Poly(vinylpyrrolidone)⁻Poly(N-isopropylacrylamide) (C⁻P⁻N) hydrogel to form an in situ forming implant (ISFI), responsive to temperature and pH for cancer cell-targeting following intraperitoneal implantation. The optimum nanomicelle formulation was surface-functionalized with anti-MUC 16 (antibody) for the targeted delivery of methotrexate to human ovarian carcinoma (NIH:OVCAR-5) cells in Athymic nude mice that expressed MUC16, as a preferential form of intraperitoneal ovarian cancer (OC) chemotherapy. The cross-linked interpenetrating C⁻P⁻N hydrogel was synthesized for the preparation of an in situ-forming implant (ISFI). Read More

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http://www.mdpi.com/1422-0067/19/10/3030
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http://dx.doi.org/10.3390/ijms19103030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213745PMC
October 2018
60 Reads
2.862 Impact Factor

Optimising amino acid absorption: essential to improve nitrogen balance and metabolic control in phenylketonuria.

Nutr Res Rev 2018 Oct 4:1-9. Epub 2018 Oct 4.

7Division of Metabolic Diseases,Beatrix Children's Hospital,University Medical Center Groningen,University of Groningen,Groningen,the Netherlands.

It has been nearly 70 years since the discovery that strict adherence to a diet low in phenylalanine prevents severe neurological sequelae in patients with phenylalanine hydroxylase deficiency (phenylketonuria; PKU). Today, dietary treatment with restricted phenylalanine intake supplemented with non-phenylalanine amino acids to support growth and maintain a healthy body composition remains the mainstay of therapy. However, a better understanding is needed of the factors that influence N balance in the context of amino acid supplementation. Read More

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https://www.cambridge.org/core/product/identifier/S095442241
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http://dx.doi.org/10.1017/S0954422418000173DOI Listing
October 2018
16 Reads
3.912 Impact Factor

Macromolecular crowding-induced molten globule states of the alkali pH-denatured proteins.

Biochim Biophys Acta Proteins Proteom 2018 11 4;1866(11):1102-1114. Epub 2018 Sep 4.

School of Chemistry and Biochemistry, Thapar University, Patiala 147004, India.

Structural and molecular properties extracted from circular dichroism (CD), tryptophan fluorescence and 1-anilino-8-napthalene sulfonate (ANS) binding experiments suggest that the high concentration of synthetic crowding agents (dextran 40, dextran 70 and ficoll 70) stabilizes and refolds the base-denatured ferricytochrome c (Ferricyt c) and lysozyme (Lyz) at pH 12.9 (±0.1) to molten globule (MG) states (C-states). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15709639183014
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http://dx.doi.org/10.1016/j.bbapap.2018.08.012DOI Listing
November 2018
2 Reads
2.750 Impact Factor

Short-term post-implantation dynamics of in vitro engineered human microvascularized adipose tissues.

Biomed Mater 2018 Oct 2;13(6):065013. Epub 2018 Oct 2.

Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, CMDGT/LOEX, Aile-R, Hôpital Enfant-Jésus, 1401, 18e Rue, Québec, Qc, G1J 1Z4, Canada. Division of Regenerative Medicine, CHU de Québec-Université Laval Research Center, 1401, 18e Rue, Québec, Qc, G1J 1Z4, Canada.

Engineered adipose tissues are developed for their use as substitutes for tissue replacement in reconstructive surgery. To ensure a timely perfusion of the grafted substitutes, different strategies can be used such as the incorporation of an endothelial component. In this study, we engineered human adipose tissue substitutes comprising of functional adipocytes as well as a natural extracellular matrix using the self-assembly approach, without the use of exogenous scaffolding elements. Read More

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http://dx.doi.org/10.1088/1748-605X/aadff7DOI Listing
October 2018
1 Read

Detecting GPC3-Expressing Hepatocellular Carcinoma with L5 Peptide-Guided Pretargeting Approach: In Vitro and In Vivo MR Imaging Experiments.

Contrast Media Mol Imaging 2018 10;2018:9169072. Epub 2018 Sep 10.

Department of Medical Imaging Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: To investigate the potential of L5 peptide-guided pretargeting approach to identify GPC3-expressing hepatocellular carcinoma (HCC) using ultrasmall superparamagnetic iron oxide (USPIO) as the MR probe.

Methods: Immunofluorescence with carboxyfluorescein- (FAM-) labeled L5 peptide was performed in HepG2 cells. Polyethylene glycol-modified USPIO (PEG-USPIO) and its conjugation with streptavidin (SA-PEG-USPIO) were synthesized, and their hydrodynamic diameters, zeta potential, T relaxivity, and cytotoxicity were measured. Read More

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https://www.hindawi.com/journals/cmmi/2018/9169072/
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http://dx.doi.org/10.1155/2018/9169072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151370PMC
January 2019
2 Reads

Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction.

Drug Des Devel Ther 2018 20;12:3061-3070. Epub 2018 Sep 20.

Department of Anaesthesiology and Reanimation, Gazi University Medical Faculty, Ankara, Turkey,

Objective: This study was conducted since the effects of colloid solutions on the renal system remain controversial and need to be adequately studied in animals. We aimed to evaluate the effects of hydroxyethyl starch (Voluven) on the kidney tissue of rats with late renal failure due to ureteral obstruction.

Materials And Methods: Rats were divided into four groups: Group C, control; Group HES, hydroxyethyl starch solution (HES) 130/0. Read More

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https://www.dovepress.com/effects-of-hydroxyethyl-starch-130
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http://dx.doi.org/10.2147/DDDT.S165695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157580PMC
December 2018
10 Reads

Novel core-shell dextran hybrid nanosystem for anti-viral drug delivery.

Mater Sci Eng C Mater Biol Appl 2018 Dec 23;93:864-872. Epub 2018 Aug 23.

International and Inter University Centre for Nanoscience and Nanotechnology,Mahatma Gandhi University, Kottayam 686 560, Kerala, India; School of Chemical Sciences, Mahatma Gandhi University, Kottayam 686 560, Kerala, India. Electronic address:

Zidovudine (AZT) is an antiviral drug extensively used for combating the global pandemic- HIV/AIDS. However, its uses are overshadowed by its short half -life, poor aqueous solubility and inability to cross physiological barriers. This study highlights a nanosystem consisting of dextran and stearic acid for AZT delivery. Read More

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http://dx.doi.org/10.1016/j.msec.2018.08.015DOI Listing
December 2018
1 Read

Hydroxide assisted synthesis of monodisperse and biocompatible gold nanoparticles with dextran.

Mater Sci Eng C Mater Biol Appl 2018 Dec 21;93:759-767. Epub 2018 Aug 21.

Yunnan Key laboratory of Optoelectronic Information Technology, College of Physics and Electronic Information, Yunnan Normal University, Kunming 650500, China.

A simple and rapid approach to synthesize monodisperse and biocompatible gold nanoparticles (AuNPs) employing dextran as a reducing and stabilizing agents at different reaction conditions was described. The obtained dextran-gold nanoparticles (Dex-AuNPs) were characterized by transmission electron microscopy (TEM), UV-Vis spectroscopy, Nuclear magnetic resonance (NMR) spectroscopy, Fourier transformer infrared (FTIR) spectroscopy and X-ray diffraction (XRD) analysis. The TEM examinations showed the resultant particles were 4-50 nm in size, monodispersity and uniform particle size distribution. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931173453
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http://dx.doi.org/10.1016/j.msec.2018.08.045DOI Listing
December 2018
8 Reads

Praziquantel systems with improved dissolution rate obtained by high pressure homogenization.

Mater Sci Eng C Mater Biol Appl 2018 Dec 20;93:28-35. Epub 2018 Jul 20.

Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), San Juan 670, 8000 Bahía Blanca, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Camino La Carrindanga Km 7, 8000 Bahía Blanca, Argentina. Electronic address:

Praziquantel (PZQ), an antihelmintic agent commonly administered to humans and cattle, has low aqueous solubility, which compromises its bioavailability and efficacy. The purpose of this study was to develop a new formulation, in order to improve PZQ dissolution rate. PZQ dispersions have been developed by high-pressure homogenization (HPH) using different stabilizers, selected upon PZQ saturation solubility. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931173368
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http://dx.doi.org/10.1016/j.msec.2018.07.050DOI Listing
December 2018
1 Read

Manipulation of osteoclastogenesis: Bioactive multiphasic silica/collagen composites and their effects of surface and degradation products.

Mater Sci Eng C Mater Biol Appl 2018 Dec 19;93:265-276. Epub 2018 Jul 19.

Max Bergmann Center of Biomaterials and Institute of Materials Science, Technical University Dresden, Budapester Str. 27, D-01069 Dresden, Germany.

The intent of the present study was to demonstrate that multiphasic silica/collagen xerogels are able to manipulate cellular processes. These xerogels were prepared by a sol-gel approach allowing the incorporation of mineral phases. The resulting nanocomposites are designed as biomaterial for bone regeneration. Read More

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http://dx.doi.org/10.1016/j.msec.2018.07.049DOI Listing
December 2018
8 Reads

Novel Orally Disintegrating Tablets Produced Using a High-Pressure Carbon Dioxides Process.

Chem Pharm Bull (Tokyo) 2018 ;66(10):932-938

Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science.

It is well known that high-pressure carbon dioxide (CO) lowers the glass transition temperature (T) of polymers. We therefore investigated whether T depression of high-pressure CO results in interparticle bridging of a polymer and the tablet characteristics that makes the manufacture of an orally disintegrating tablet (ODT) possible. Copolyvidone (Kollidon) and polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus) were examined and found to exhibit a large T depression. Read More

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https://www.jstage.jst.go.jp/article/cpb/66/10/66_c18-00220/
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http://dx.doi.org/10.1248/cpb.c18-00220DOI Listing
October 2018
6 Reads

Differential effect of polyvinylpyrrolidone-coated superparamagnetic iron oxide nanoparticles on BT-474 human breast cancer cell viability.

Toxicol In Vitro 2019 Feb 25;54:114-122. Epub 2018 Sep 25.

Department of Chemistry, Catalysis Division, University of Isfahan, Isfahan, Iran.

Polyvinylpyrrolidone superparamagnetic iron oxide nanoparticles (PVP-SPIONs) have unique properties. Due to these characteristics, PVP-SPIONs have been used in several medical applications such as magnetic resonance imaging (MRI) contrast agent or drug delivery system. However, a more comprehensive understanding of the environmental safety of PVP-SPIONs is vital for consumption of these nanomaterials. Read More

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http://dx.doi.org/10.1016/j.tiv.2018.09.018DOI Listing
February 2019
7 Reads

Isolation, Characterization and Antitumor Effect on DU145 Cells of a Main Polysaccharide in Pollen of Chinese Wolfberry.

Molecules 2018 Sep 21;23(10). Epub 2018 Sep 21.

Institute of Wolfberry Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, China.

Modern studies have shown that pollen has a certain role in the treatment of prostate-related diseases. In the present study, pollen polysaccharides from Chinese wolfberry (WPPs) were extracted by hot-water extraction and ethanol precipitation, further purified by chromatography on a DEAE-cellulose column and Sephadex G-100 column. Homogeneous polysaccharide CF1 of WPPS was obtained, the molecular weight of which was estimated to be 1540. Read More

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http://dx.doi.org/10.3390/molecules23102430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222688PMC
September 2018
2 Reads

Scar free healing mediated by the release of aloe vera and manuka honey from dextran bionanocomposite wound dressings.

Int J Biol Macromol 2018 Dec 21;120(Pt B):1581-1590. Epub 2018 Sep 21.

Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology Delhi, New Delhi 110016, India. Electronic address:

Scar preventive dextran based bionanocomposite dressings containing aloe vera (AV) and manuka honey (MH) were developed as wound care devices. This work was a challenge to fabricate herbal dressing that promotes healing, which at the same time is biocompatible, non-toxic, biodegradable, and cost effective in terms of the simplicity of application in complex chronic wound situations. With this aim, we synthesized in-situ crosslinked dextran/nanosoy/glycerol/chitosan (DNG/Ch) nanocomposite membranes via solvent casting technique followed by subsequent addition of AV and MH to obtain DNG/Ch/AV and DNG/Ch/MH herbal dressings. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.09.124DOI Listing
December 2018
6 Reads

Antioxidative and hepatoprotective effects of enzymatic and acidic-hydrolysis of Pleurotus geesteranus mycelium polysaccharides on alcoholic liver diseases.

Carbohydr Polym 2018 Dec 15;201:75-86. Epub 2018 Aug 15.

College of Life Science, Shandong Agricultural University, Taian, 271018, PR China. Electronic address:

The present work investigated the antioxidant and hepatoprotective effects of acidic- and enzymatic-hydrolysis mycelium polysaccharide (AcMPS and EnMPS) from Pleurotus geesteranus on alcoholic liver disease (ALD) mice. The animal studies demonstrated that the polysaccharides had potential effects reflected by remitting alcoholic hepatitis, reducing lipid accumulation, preventing oxidative stress, improving inflammatory symptoms, and alleviating the liver functions by histopathologic observation. Results showed that AcMPS (yield of 84%) was composed of L-Rha, D-Rib, L-Ara, D-Glc, D-Man and D-Gal with the Mw of 3. Read More

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http://dx.doi.org/10.1016/j.carbpol.2018.08.058DOI Listing
December 2018
2 Reads
4.074 Impact Factor

Glutathione responsive chitosan-thiolated dextran conjugated miR-145 nanoparticles targeted with AS1411 aptamer for cancer treatment.

Carbohydr Polym 2018 Dec 17;201:131-140. Epub 2018 Aug 17.

Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box, 14155-6451, Tehran, Iran; Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

miR-145 is a tumor suppressive miRNA which is abnormally reduced in different cancers. miR-145 overexpression reduces cancer migration, invasion, and cell adhesion. Increasing miR-145 level using suitable and efficient gene delivery systems could be valuable in cancer treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01448617183096
Publisher Site
http://dx.doi.org/10.1016/j.carbpol.2018.08.060DOI Listing
December 2018
16 Reads
4.074 Impact Factor