45,099 results match your criteria Blood Substitutes

3D Printing of Strontium Silicate Microcylinder-Containing Multicellular Biomaterial Inks for Vascularized Skin Regeneration.

Adv Healthc Mater 2021 May 8:e2100523. Epub 2021 May 8.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.

The reconstruction of dermal blood vessels is essential for skin regeneration process. However, the lack of vascular structure, insufficient angiogenesis induction, and ineffective graft-host anastomosis of the existing skin substitutes are major bottle-necks for permanent skin replacement in tissue engineering. In this study, the uniform strontium silicate (SS) microcylinders are successfully synthesized and integrated into the biomaterial ink to serve as stable cell-induced factors for angiogenesis, and then a functional skin substitute based on a vascularization-induced biomimetic multicellular system is prepared via a "cell-writing" bioprinting technology. Read More

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Development of a Lyophilization Process for Long-Term Storage of Albumin-Based Perfluorodecalin-Filled Artificial Oxygen Carriers.

Pharmaceutics 2021 Apr 20;13(4). Epub 2021 Apr 20.

Institute of Pharmaceutical Technology and Biopharmacy, University of Muenster, Corrensstr. 48, 48149 Muenster, Germany.

Every day, thousands of patients receive erythrocyte concentrates (ECs). They are indispensable for modern medicine, despite their limited resource. Artificial oxygen carriers (AOCs) represent a promising approach to reduce the need for ECs. Read More

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Growth and Body Composition in PKU Children-A Three-Year Prospective Study Comparing the Effects of L-Amino Acid to Glycomacropeptide Protein Substitutes.

Nutrients 2021 Apr 16;13(4). Epub 2021 Apr 16.

Birmingham Women's and Children's Hospital, NHS Foundation Trust, Birmingham B4 6NH, UK.

Protein quality and quantity are important factors in determining lean body (muscle) mass (LBM). In phenylketonuria (PKU), protein substitutes provide most of the nitrogen, either as amino acids (AA) or glycomacropeptide with supplementary amino acids (CGMP-AA). Body composition and growth are important indicators of long-term health. Read More

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Exploring the Biomaterial-Induced Secretome: Physical Bone Substitute Characteristics Influence the Cytokine Expression of Macrophages.

Int J Mol Sci 2021 Apr 24;22(9). Epub 2021 Apr 24.

Institute of Pathology, Repair-Lab, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.

In addition to their chemical composition various physical properties of synthetic bone substitute materials have been shown to influence their regenerative potential and to influence the expression of cytokines produced by monocytes, the key cell-type responsible for tissue reaction to biomaterials in vivo. In the present study both the regenerative potential and the inflammatory response to five bone substitute materials all based on β-tricalcium phosphate (β-TCP), but which differed in their physical characteristics (i.e. Read More

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Histological Comparison between Biphasic Calcium Phosphate and Deproteinized Bovine Bone on Critical-Size Bone Defects.

Braz Dent J 2021 Jan-Feb;32(1):26-33

Department of Stomatology, UFPR - Universidade Federal do Paraná, Curitiba, PR, Brazil.

The limited options for bone repair have led to an extensive research of the field and the development of alloplastic and xenogeneic grafts. The purpose of this study was to evaluate bone repair with two bone substitutes: deproteinized bovine bone (DBB) and biphasic calcium phosphate ceramic (BCP) in critical-size defect. A total of 8-mm defects were made in the parietal bones of rabbits (n=12). Read More

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[Fluid and Volume Therapy with Crystalloid and Colloidal Infusion Solutions].

Anasthesiol Intensivmed Notfallmed Schmerzther 2021 Apr 22;56(4):232-245. Epub 2021 Apr 22.

A rational infusion therapy orchestrates fluid- and volume therapy based on the individual indication and situation. The principle of fluid replacement is to substitute ongoing fluid losses such as insensible perspiration and urine output or to treat dehydration with balanced crystalloid solutions. Volume therapy in contrast is the quick restoration of intravascular losses such as an acute blood loss through application of balanced colloids or crystalloids. Read More

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The mechanical characterization of blood vessels and their substitutes in the continuous quest for physiological-relevant performances. A critical review.

Mater Today Bio 2021 Mar 7;10:100106. Epub 2021 Mar 7.

Laboratory for Biomaterials and Bioengineering, Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in Surgery, Department of Min-Met-Materials Engineering, Research Center of CHU de Québec, Division of Regenerative Medicine, Laval University, Québec, QC, G1V 0A6, Canada.

During the last 50 years, novel biomaterials and tissue engineering techniques have been investigated to produce alternative vascular substitutes that recapitulate the unique elastic mechanical features of blood vessels. A large variation in mechanical characterization, including the test type, protocol, and data analysis, is present in literature which complicates the comparison among studies and prevents the blooming and the advancement of this field. In addition, a limited mechanical assessment of the substitute for the intended application is often provided. Read More

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A Review of Topical Povidone-iodine to Decrease Viral Load of COViD-19.

Sr Care Pharm 2021 May;36(5):238-241

Topical povidone-iodine (PVP-I) is currently being considered as a potential preventive measure against the spread of COVID-19. Diluted PVP-I solutions have been historically used in Asia to treat upper respiratory tract infections (URTIs) by decreasing the bacterial and viral load on oropharyngeal mucosa to decrease the transmission of diseases. Efficacy of gargling 0. Read More

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Meniscal Salvage: Where We Are Today.

J Am Acad Orthop Surg 2021 Apr 16. Epub 2021 Apr 16.

From the Division of Orthopaedics, Department of Surgery, Walter Reed National Military Medical Center, Uniformed Services University, Bethesda, MD (Anderson and Dickens), Geneva Foundation, Tacoma, WA (Gaston), the Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD (Gaston), and United States Naval Academy, Naval Health Clinic Annapolis, Annapolis, MD (LeClere).

The menisci are fibrocartilaginous semilunar structures in the knee that provide load support. Injury to the meniscus alters its load sharing and biomechanical profile. Knee arthroscopy with meniscus débridement is the most common orthopaedic surgical procedure done in the United States. Read More

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Translational research of hemoglobin vesicles as a transfusion alternative.

Curr Med Chem 2021 Apr 12. Epub 2021 Apr 12.

Department of Chemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521. Japan.

Clinical situations arise in which blood for transfusion becomes scarce or unavailable. Considerable demand for a transfusion alternative persists because of various difficulties posed by blood donation and transfusion systems. Hemoglobin-vesicles (HbV) are artificial oxygen carriers being developed for use as a transfusion alternative. Read More

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Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry.

Scand J Trauma Resusc Emerg Med 2021 Apr 9;29(1):57. Epub 2021 Apr 9.

Hematopathology, Pathology Department, CDB, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain.

Background: Colloid fluids supplemented with adequate combinations of coagulation factor concentrates with the capability to restore coagulation could be a desirable future treatment component in massive transfusion.

Methods: Starting from a coagulation factor and blood cell-free albumin solution we added Prothrombin Complex Concentrate, Fibrinogen Concentrate and Factor XIII in different combinations and concentrations to analyze their properties to restore thromboelastometry parameters without the use of plasma. Further analysis under the presence of platelets was performed for comparability to whole blood conditions. Read More

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Structural Stability and Biophysical Properties of the Mega-Protein Erythrocruorin Are Regulated by Polyethylene Glycol Surface Coverage.

Biomacromolecules 2021 Apr 6. Epub 2021 Apr 6.

William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.

A wide variety of hemoglobin-based oxygen carriers (HBOCs) have been designed for use as red blood cell (RBC) substitutes in transfusion medicine, organ perfusion, oxygen delivery to hypoxic tissues, and a myriad of other applications. However, hemoglobin (Hb) derived from annelids (erythrocruorins [Ecs]) comprise a natural class of HBOC, since they are larger in size (30 nm in diameter) and contain more heme groups per molecule (144 heme groups) compared to human Hb (hHb; 5 nm in diameter and 4 heme groups). The larger size of Ec compared to hHb reduces tissue extravasation from the vascular space, thus, reducing vasoconstriction, systemic hypertension, and tissue oxidative injury when used as an RBC substitute. Read More

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Pre-Treat Xenogenic Collagenous Blocks of Bone Substitutes with Saline Facilitate Their Manipulation and Guarantee High Bone Regeneration Rates, Qualitatively and Quantitatively.

Biomedicines 2021 Mar 17;9(3). Epub 2021 Mar 17.

Biomaterials Laboratory, Division of Fixed Prosthodontics and Biomaterials, University of Geneva, University Clinics of Dental Medicine, 1, rue Michel Servet, 1204 Geneva, Switzerland.

Deproteinized bovine bone mineral particles embedded in collagen (DBBM-C) are widely used for bone regenerations with excellent, albeit sometimes variable clinical outcomes. Clinicians usually prepare DBBM-C by mixing with blood. Replacing blood by saline represents an alternative. Read More

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Synthesis of Densely Immobilized Gold-Assembled Silica Nanostructures.

Int J Mol Sci 2021 Mar 3;22(5). Epub 2021 Mar 3.

Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea.

In this study, dense gold-assembled SiO nanostructure (SiO@Au) was successfully developed using the Au seed-mediated growth. First, SiO (150 nm) was prepared, modified by amino groups, and incubated by gold nanoparticles (ca. 3 nm Au metal nanoparticles (NPs)) to immobilize Au NPs to SiO surface. Read More

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Complement-Opsonized Nano-Carriers Are Bound by Dendritic Cells (DC) via Complement Receptor (CR)3, and by B Cell Subpopulations via CR-1/2, and Affect the Activation of DC and B-1 Cells.

Int J Mol Sci 2021 Mar 11;22(6). Epub 2021 Mar 11.

Department of Dermatology, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.

The development of nanocarriers (NC) for biomedical applications has gained large interest due to their potential to co-deliver drugs in a cell-type-targeting manner. However, depending on their surface characteristics, NC accumulate serum factors, termed protein corona, which may affect their cellular binding. We have previously shown that NC coated with carbohydrates to enable biocompatibility triggered the lectin-dependent complement pathway, resulting in enhanced binding to B cells via complement receptor (CR)1/2. Read More

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No evidence of racial disparities in blood pressure salt sensitivity when potassium intake exceeds levels recommended in the US dietary guidelines.

Am J Physiol Heart Circ Physiol 2021 May 2;320(5):H1903-H1918. Epub 2021 Apr 2.

Department of Medicine, University of California, San Francisco, California.

On average, black individuals are widely believed to be more sensitive than white individuals to blood pressure (BP) effects of changes in salt intake. However, few studies have directly compared the BP effects of changing salt intake in black versus white individuals. In this narrative review, we analyze those studies and note that when potassium intake substantially exceeds the recently recommended US dietary goal of 87 mmol/day, black adults do not appear more sensitive than white adults to BP effects of short-term or long-term increases in salt intake (from an intake ≤50 mmol/day up to 150 mmol/day or more). Read More

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Effects of a reduced-sodium added-potassium salt substitute on blood pressure in rural Indian hypertensive patients: a randomized, double-blind, controlled trial.

Am J Clin Nutr 2021 Mar 30. Epub 2021 Mar 30.

The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

Background: High salt intake is a major modifiable risk factor of hypertension which is prevalent in India. It is not yet clear if salt substitutes reduce blood pressure (BP) among Indian hypertensive patients.

Objectives: Examine the acceptability, usage, and BP effects of a reduced-sodium and added-potassium salt substitute among hypertensive patients. Read More

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F Magnetic Resonance Imaging and Spectroscopy in Neuroscience.

Michel Modo

Neuroscience 2021 Mar 23. Epub 2021 Mar 23.

Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

H magnetic resonance imaging (MRI) has established itself as a key diagnostic technique, affording the visualization of brain anatomy, blood flow, activity and connectivity. The detection of other atoms (e.g. Read More

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Effect of BH4 on blood phenylalanine and tyrosine variations in patients with phenylketonuria.

Mol Genet Metab 2021 05 6;133(1):49-55. Epub 2021 Mar 6.

Division of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, the Netherlands. Electronic address:

Background: In patients with phenylketonuria, stability of blood phenylalanine and tyrosine concentrations might influence brain chemistry and therefore patient outcome. This study prospectively investigated the effects of tetrahydrobiopterin (BH4), as a chaperone of phenylalanine hydroxylase on diurnal and day-to-day variations of blood phenylalanine and tyrosine concentrations.

Methods: Blood phenylalanine and tyrosine were measured in dried blood spots (DBS) four times daily for 2 days (fasting, before lunch, before dinner, evening) and once daily (fasting) for 6 days in a randomized cross-over design with a period with BH4 and a period without BH4. Read More

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Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus.

Cochrane Database Syst Rev 2021 03 23;3:CD013512. Epub 2021 Mar 23.

Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: Keratoconus is the most common corneal dystrophy. It can cause loss of uncorrected and best-corrected visual acuity through ectasia (thinning) of the central or paracentral cornea, irregular corneal scarring, or corneal perforation. Disease onset usually occurs in the second to fourth decade of life, periods of peak educational attainment or career development. Read More

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Bone substitutes and photobiomodulation in bone regeneration: A systematic review in animal experimental studies.

J Biomed Mater Res A 2021 Mar 17. Epub 2021 Mar 17.

Department of Biosciences, Federal University of São Paulo (UNIFESP), Santos, São Paulo, Brazil.

In general, bone fractures are able of healing by itself. However, in critical situations such as large bone defects, poor blood supply or even infections, the biological capacity of repair can be impaired, resulting in a delay of the consolidation process or even in non-union fractures. Thus, technologies able of improving the process of bone regeneration are of high demand. Read More

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An Efficient Synthesis of Novel Dextran-Arsenite Nanoparticles intended for Potential Antitumor Drug Material.

An Acad Bras Cienc 2021 15;93(2):e20190551. Epub 2021 Mar 15.

Guangxi University, College of Light Industry and Food Engineering, No.100, Daxue East Road, Nanning, 530004, Guangxi, China.

The functionalization of polysaccharides with synthetic nanopolymers has attracted great attention owing to the applications of this method in many industrial fields. This work aimed to investigate the effect of arsenic trioxide on the functionalization of dextran. Dextran-arsenite nanoparticle formation was induced by microwave with sulfuric acid as a catalyst. Read More

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Engineering motile aqueous phase-separated droplets via liposome stabilisation.

Nat Commun 2021 03 15;12(1):1673. Epub 2021 Mar 15.

Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, 82 Wood Lane, London, W12 0BZ, UK.

There are increasing efforts to engineer functional compartments that mimic cellular behaviours from the bottom-up. One behaviour that is receiving particular attention is motility, due to its biotechnological potential and ubiquity in living systems. Many existing platforms make use of the Marangoni effect to achieve motion in water/oil (w/o) droplet systems. Read More

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USPIO-enhanced MRI of lymph nodes in rectal cancer: A node-to-node comparison with histopathology.

Eur J Radiol 2021 May 10;138:109636. Epub 2021 Mar 10.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Erwin L. Hahn Institute for MR Imaging, University of Duisburg-Essen, Essen, 45141, Germany.

Purpose: To evaluate the initial results of predicting lymph node metastasis in rectal cancer patients detected in-vivo with USPIO-enhanced MRI at 3 T compared on a node-to-node basis with histopathology.

Methods: Ten rectal cancer patients of all clinical stages were prospectively included for an in-vivo 0.85 mm isotropic 3D MRI after infusion of Ferumoxtran-10. Read More

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Clinical Outcomes and Medical Costs of Hydration Therapy with Hydroxyethyl Starch (130/0.4) or Acute Single Infarction.

J Stroke Cerebrovasc Dis 2021 May 10;30(5):105705. Epub 2021 Mar 10.

Department of Rehabilitation Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Objectives: To investigate the effects of hydration with or without Hydroxyethyl Starch (HES) 130/0.4 on neurological outcomes and medical costs during hospitalisation in patients with a single infarction (SI) in the posterior lenticulostriate artery (LSA) territory.

Materials And Methods: In this retrospective, single-centre, non-blinded cohort study, SI in the posterior LSA was defined as an ischaemic lesion with a high-signal intensity area ≥20 mm. Read More

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Neurotensin: A novel mediator of ovulation?

FASEB J 2021 Apr;35(4):e21481

Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, USA.

The midcycle luteinizing hormone (LH) surge initiates a cascade of events within the ovarian follicle which culminates in ovulation. Only mural granulosa cells and theca cells express large numbers of LH receptors, and LH-stimulated paracrine mediators communicate the ovulatory signal within the follicle. Recent reports identified the neuropeptide neurotensin (NTS) as a product of granulosa cells. Read More

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The cost-effectiveness of government actions to reduce sodium intake through salt substitutes in Vietnam.

Arch Public Health 2021 Mar 11;79(1):32. Epub 2021 Mar 11.

The George Institute for Global Health, Australia University of NSW, PO Box M201, Missenden Rd, Camperdown, NSW, 2050, Australia.

Background: Dietary sodium reduction is recommended to reduce the burden of cardiovascular disease. In Vietnam food products including salt, fish sauce and bot canh contribute to ~ 70% of dietary sodium intake. Reduced sodium versions of these products can be produced by replacing some of the sodium chloride with potassium chloride. Read More

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Umbilical vein injection for management of retained placenta.

Cochrane Database Syst Rev 2021 03 11;3:CD001337. Epub 2021 Mar 11.

Department of Women's and Children's Health, The University of Liverpool, Liverpool, UK.

Background: Retained placenta is a common complication of pregnancy affecting 1% to 6% of all births. If a retained placenta is left untreated, spontaneous delivery of the placenta may occur, but there is a high risk of bleeding and infection. Manual removal of the placenta (MROP) in an operating theatre under anaesthetic is the usual treatment, but is invasive and may have complications. Read More

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Preparation of dextran-casein phosphopeptide conjugates, evaluation of its calcium binding capacity and digestion in vitro.

Food Chem 2021 Aug 20;352:129332. Epub 2021 Feb 20.

State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Engineering, Tianjin University of Science & Technology, No. 29, No. 13 Ave., TEDA, Tianjin 300457, China. Electronic address:

In order to construct a novel and efficient calcium delivery system, a dextran- casein phosphopeptide (CPP) conjugates as calcium carrier was prepared by Maillard reaction of CPP and dextran. The preparation of the conjugates, construction of calcium delivery system and digestion in vitro were studied. The grafting rate of conjugates, which was confirmed by migration and intensity changes in the characteristic peaks using ultraviolet-visible and Fourier transform infrared spectroscopy, reached 48. Read More

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High-resolution T MRI via renally clearable dextran nanoparticles with an iron oxide shell.

Nat Biomed Eng 2021 03 8;5(3):252-263. Epub 2021 Mar 8.

Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea.

Contrast agents for magnetic resonance imaging (MRI) improve anatomical visualizations. However, owing to poor image resolution in whole-body MRI, resolving fine structures is challenging. Here, we report that a nanoparticle with a polysaccharide supramolecular core and a shell of amorphous-like hydrous ferric oxide generating strong T MRI contrast (with a relaxivity coefficient ratio of ~1. Read More

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