Efficacy and safety of early versus late titration of fixed-dose irbesartan/hydrochlorothiazide: ACTUAL study.
Blood Press Suppl 2011 Dec;2:22-9
Assistance Publique - Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Service Endocrinologie, Unité de Prévention Cardiovasculaire, Paris, France.
Hypertension management guidelines recommend titrating antihypertensive drugs stepwise every 4-6 weeks.We compared efficacy and safety of early versus late titration after 10 weeks' treatment with irbesartan/hydrochlorothiazide. Hypertensive patients uncontrolled on monotherapy were randomized into two groups. Read More