4,790 results match your criteria Blood Dyscrasias and Stroke


Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial.

JAMA 2019 Feb;321(6):553-561

National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Importance: There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia.

Objective: To evaluate the effect of intensive blood pressure control on risk of dementia.

Design, Setting, And Participants: Randomized clinical trial conducted at 102 sites in the United States and Puerto Rico among adults aged 50 years or older with hypertension but without diabetes or history of stroke. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.21442DOI Listing
February 2019
28 Reads

Matched Sibling Donor Hematopoietic Stem Cell Transplantation to Prevent Stroke in Children With Sickle Cell Anemia.

JAMA 2019 01;321(3):251-252

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1001/jama.2018.20390DOI Listing
January 2019
1 Read

Prevalence, risk factors, and significance of iron deficiency and anemia in nonischemic heart failure patients with reduced ejection fraction from a Himachal Pradesh heart failure registry.

Indian Heart J 2018 Dec 2;70 Suppl 3:S182-S188. Epub 2018 Nov 2.

IGMC Shimla, HP, India.

Background: The study aimed to estimate the prevalence, risk determinants, and its clinical significance of iron deficiency and anemia in patients of nonischemic heart failure with reduced ejection fraction (HFrEF).

Methods: Serum ferritin, transferrin saturation, and the hemoglobin (Hb) levels were measured in 226 consecutive patients with HFrEF diagnosed based on the left ventricular ejection fraction ≤ 45% and absence of coronary artery luminal narrowing of more than 50%, in a prospective tertiary care hospital-based heart failure registry. Patients with the New York Heart Association functional class III/IV were classified as patients with advanced heart failure. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310070PMC
December 2018
1 Read

A case report of cerebral infarction caused by polycythemia vera.

Medicine (Baltimore) 2018 Dec;97(52):e13880

Department of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.

Rationale: Polycythemia vera (PV) is a cloned erythrocytotic disease manifested by high proliferation and apoptosis in the bone marrow. The clinical symptoms of PV are occult. In practice, patients with cerebral infarction caused by PV are prone to misdiagnosis and missed diagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314744PMC
December 2018
1 Read

Use of Measures of Inflammation and Kidney Function for Prediction of Atherosclerotic Vascular Disease Events and Death in Patients With CKD: Findings From the CRIC Study.

Am J Kidney Dis 2018 Dec 10. Epub 2018 Dec 10.

Division of Kidney Diseases and Hypertension, George Washington University, Washington, DC. Electronic address:

Rationale & Objective: Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney disease (CKD). We sought to determine whether the addition of measures of inflammation and kidney function to traditional estimation tools improves prediction of these events in a diverse cohort of patients with CKD.

Study Design: Observational cohort study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.09.012DOI Listing
December 2018
2 Reads
5.900 Impact Factor

Adult and pediatric mechanical circulation: a guide for the hematologist.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):507-515

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Mechanical circulatory support (MCS) is the overarching term that encompasses the temporary and durable devices used in patients with severe heart failure. MCS disturbs the hematologic and coagulation system, leading to platelet activation, activation of the contact pathway of coagulation, and acquired von Willebrand syndrome. Ischemic stroke and major hemorrhage occur in up to 30% of patients. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245997PMC
November 2018
1 Read

Prevalence of comorbidities in systemic sclerosis versus rheumatoid arthritis: a comparative, multicenter, matched-cohort study.

Arthritis Res Ther 2018 Dec 4;20(1):267. Epub 2018 Dec 4.

Joint Rheumatology Program, 1st Department of Propedeutic Internal Medicine-Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens, Greece.

Background: Comorbidities are common in chronic systemic connective tissue diseases and are associated with adverse outcomes, increased morbidity and mortality. Although the prevalence of comorbidities has been well-studied in isolated diseases, comparative studies between different autoimmune diseases are limited. In this study, we compared the prevalence of common comorbidities between patients with systemic sclerosis (SSc) and patients with rheumatoid arthritis (RA). Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1771-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280404PMC
December 2018
10 Reads

Investigating the ability of non-invasive measures of cardiac output to detect a reduction in blood volume resulting from venesection in spontaneously breathing subjects.

Scand J Trauma Resusc Emerg Med 2018 Dec 4;26(1):104. Epub 2018 Dec 4.

Emergency Department, Royal London Hospital, Barts Health NHS Trust, London, UK.

Background: Monitoring cardiac output (CO) in shocked patients provides key etiological information and can be used to guide fluid resuscitation to improve patient outcomes. Previously this relied on invasive monitoring, restricting its use in the Emergency Department (ED) setting. The development of non-invasive devices (such as LiDCOrapid with CNAP™ and USCOM 1A), and ultrasound based measurements (Transthoracic echocardiography, inferior vena cava collapsibility index (IVCCI), carotid artery blood flow (CABF) and carotid artery corrected flow time (FTc)) enables stroke volume (SV) and CO to be measured non-invasively in the ED. Read More

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https://sjtrem.biomedcentral.com/articles/10.1186/s13049-018
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http://dx.doi.org/10.1186/s13049-018-0571-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280441PMC
December 2018
2 Reads

Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke.

World J Gastroenterol 2018 Nov;24(43):4950-4958

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Province, China.

Aim: To investigate the specific biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke (CRCIS).

Methods: A retrospective study was conducted on CRCIS patients (colorectal cancer patients with ischemic stroke without conventional stroke risk factors) registered at seven centers between January 2007 and December 2017. Clinical data and laboratory and imaging findings were compared with age- and sex- matched patients with colorectal cancer (CRC) without ischemic stroke that were admitted to the same hospital during the same period. Read More

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http://dx.doi.org/10.3748/wjg.v24.i43.4950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250925PMC
November 2018
1 Read

Impact of anemia on percutaneous coronary intervention in Chinese patients: A large single center data.

J Interv Cardiol 2018 Dec 22;31(6):826-833. Epub 2018 Nov 22.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Objectives: To investigate the impact of anemia on 2-year outcomes in patients undergoing contemporary percutaneous coronary intervention (PCI).

Background: Whether anemia is an independent predictor of adverse outcomes after PCI is under debate.

Methods: A total of 10 717 consecutive patients who underwent PCI with available hemoglobin values at Fuwai Hospital were collected. Read More

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http://dx.doi.org/10.1111/joic.12570DOI Listing
December 2018
2 Reads

Fetal stroke and cerebrovascular disease: Advances in understanding from lenticulostriate and venous imaging, alloimmune thrombocytopaenia and monochorionic twins.

Eur J Paediatr Neurol 2018 Nov 11;22(6):989-1005. Epub 2018 Sep 11.

Departments of Child Health, Obstetrics and Gynaecology and Radiology, University Hospital Southampton, United Kingdom; Clinical and Experimental Sciences, University of Southampton, United Kingdom.

Fetal stroke is an important cause of cerebral palsy but is difficult to diagnose unless imaging is undertaken in pregnancies at risk because of known maternal or fetal disorders. Fetal ultrasound or magnetic resonance imaging may show haemorrhage or ischaemic lesions including multicystic encephalomalacia and focal porencephaly. Serial imaging has shown the development of malformations including schizencephaly and polymicrogyra after ischaemic and haemorrhagic stroke. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.08.008DOI Listing
November 2018
12 Reads

Plasma Phospholipid Transfer Protein Promotes Platelet Aggregation.

Thromb Haemost 2018 Dec 12;118(12):2086-2097. Epub 2018 Nov 12.

Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, United States.

It remains unclear whether plasma phospholipid transfer protein (PLTP) is involved in hyper-coagulation or hypo-coagulation. This study investigated the direct effect of PLTP on platelet aggregation and the underlying mechanism. Washed platelets from humans or mice and mouse platelet-rich plasma and human recombinant PLTP were isolated. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1675228
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http://dx.doi.org/10.1055/s-0038-1675228DOI Listing
December 2018
6 Reads

Hemichorea associated with cavernous angioma and a small errhysis: A case report and literature review.

Medicine (Baltimore) 2018 Oct;97(43):e12889

Departments of Neurosurgery.

Rationale: Chorea is a movement disorder characterized by randomly appearing involuntary movements of the face, neck, limbs, or trunk. Hemichorea is unilateral, involving one side of the body. Hemichorea is commonly caused by non-ketotic hyperglycemia and/or cerebrovascular injury to the contralateral basal ganglia. Read More

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http://dx.doi.org/10.1097/MD.0000000000012889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221695PMC
October 2018
1 Read

Angiotensinogen M235T Gene Polymorphism is a Genetic Determinant of Cerebrovascular and Cardiopulmonary Morbidity in Adolescents with Sickle Cell Disease.

J Stroke Cerebrovasc Dis 2019 Feb 5;28(2):441-449. Epub 2018 Nov 5.

Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address:

Background: Cerebrovascular stroke is a common critical complication of sickle cell disease (SCD). Angiotensinogen (AGT) M235T gene polymorphism is associated with risk of ischemic stroke and cardiovascular disease.

Aim: We investigated the potential association between angiotensinogen M235T gene polymorphism and susceptibility to cerebrovascular and cardiopulmonary complications in adolescents with SCD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183059
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.019DOI Listing
February 2019
54 Reads
1.993 Impact Factor

Indwelling ports for prophylactic RBC exchanges in sickle cell patients: Comparison of bard and vortex ports.

J Clin Apher 2018 Dec 2;33(6):666-670. Epub 2018 Nov 2.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Introduction: Red blood cell exchange (RCE) procedures are commonly used for stroke prevention in sickle cell disease (SCD) patients. We compared two different dual lumen ports used for RCE because differences between the port and catheter design may lead to functional variance.

Methods: We reviewed the RCE parameters of SCD patients following implantable port placement encountered at a single institution. Read More

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http://dx.doi.org/10.1002/jca.21663DOI Listing
December 2018

Recurrent thrombosis after carotid endarterectomy secondary to activated protein C resistance and essential thrombocytosis: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e13118

Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, Ulsan University, Republic of Korea.

Rationale: Thrombosis is a major cause of morbidity in the perioperative period. Although many risk factors are known, activated protein C resistance is a prominent risk for thrombosis. Activated protein C resistance frequently occurs with recurrent thromboembolism. Read More

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http://dx.doi.org/10.1097/MD.0000000000013118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221756PMC
November 2018
3 Reads

Safety of Therapeutic Plasma Exchange for the Treatment of Guillain-Barré Syndrome in Polycythemia Vera.

Neurologist 2018 Nov;23(6):185-187

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York.

Polycythemia vera (PV) is a risk factor for systemic thromboses and ischemic stroke. This has been attributed to blood hyperviscosity, the result of increased blood cell production. Intravenous immunoglobulin, which is indicated for the treatment of numerous hematologic and neurological conditions also causes increased serum viscosity and has been associated with ischemic strokes in the setting of PV. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000197DOI Listing
November 2018
7 Reads

Intravenous Iron in Patients Undergoing Maintenance Hemodialysis.

N Engl J Med 2019 01 26;380(5):447-458. Epub 2018 Oct 26.

From the Department of Renal Medicine, King's College Hospital (I.C.M., C.W.), and University College London (D.C.W.), London, Hull and East Yorkshire Hospitals NHS Trust and Hull York Medical School, Hull (S.B.), Lister Hospital, Stevenage (K.F.), and University of Hertfordshire, Hertfordshire (K.F.), the Department of Renal Medicine, Salford Royal NHS Foundation Trust, Salford (P.A.K.), the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics (H.M., I.F.), University of Glasgow, Glasgow, Freeman Hospital, Newcastle upon Tyne (C.R.V.T.), and the Oxford Kidney Unit, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford (C.G.W.) - all in the United Kingdom; and the Division of Cardiology and Metabolism, Department of Cardiology, Berlin-Brandenburg Center for Regenerative Therapies, German Center for Cardiovascular Research partner site Berlin, Charité Universitätsmedizin Berlin, Berlin (S.D.A.).

Background: Intravenous iron is a standard treatment for patients undergoing hemodialysis, but comparative data regarding clinically effective regimens are limited.

Methods: In a multicenter, open-label trial with blinded end-point evaluation, we randomly assigned adults undergoing maintenance hemodialysis to receive either high-dose iron sucrose, administered intravenously in a proactive fashion (400 mg monthly, unless the ferritin concentration was >700 μg per liter or the transferrin saturation was ≥40%), or low-dose iron sucrose, administered intravenously in a reactive fashion (0 to 400 mg monthly, with a ferritin concentration of <200 μg per liter or a transferrin saturation of <20% being a trigger for iron administration). The primary end point was the composite of nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure, or death, assessed in a time-to-first-event analysis. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1810742
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http://dx.doi.org/10.1056/NEJMoa1810742DOI Listing
January 2019
27 Reads

Multiple nodular dural cavernous angiomas occluding superior sagittal sinus and destructing calvarium: Case report and literature review.

J Clin Neurosci 2018 Dec 16;58:218-221. Epub 2018 Oct 16.

Department of Neurosurgery, Peking University International Hospital, Peking University Health Science Center, Beijing 102206, PR China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, PR China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100050, PR China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100050, PR China. Electronic address:

Dural cavernous angiomas (CAs) outside the middle cranial fossa are uncommon vascular lesions that generally present with benign clinical course compared to those within the middle cranial fossa. Aggressive invasion of these lesions is less common and mainly involves the skull. Dura sinus invasion and diffused nodular growth are exceedingly rare. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.10.015DOI Listing
December 2018
2 Reads

Triple therapy: worth the risk?

Minerva Med 2018 Oct;109(5):403-405

Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany -

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https://www.minervamedica.it/index2.php?show=R10Y2018N05A040
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http://dx.doi.org/10.23736/S0026-4806.18.05564-7DOI Listing
October 2018
6 Reads

Increased Risk of Ischemic Stroke in Multiple Myeloma Associated With Lenalidomide Treatment: A Case Report and Review of the Literature.

Clin Neuropharmacol 2018 Nov/Dec;41(6):232-235

Department of Neurology and Stroke Center, La Paz University Hospital, Autonomous University of Madrid, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain.

Objective: The aim of the study was to illustrate the increased risk of ischemic stroke in the context of multiple myeloma (MM) under treatment with lenalidomide combined with dexamethasone.

Methods: This is a case report and literature review.

Results: A 62-year-old woman diagnosed with relapsed MM under treatment with lenalidomide and dexamethasone presented with acute onset disorientation, disturbed behavior, and aphasia. Read More

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http://dx.doi.org/10.1097/WNF.0000000000000310DOI Listing
December 2018
21 Reads

Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders.

Eur J Hum Genet 2019 Jan 25;27(1):150-159. Epub 2018 Sep 25.

Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92093, USA.

The Central Asian Kyrgyz highland population provides a unique opportunity to address genetic diversity and understand the genetic mechanisms underlying high-altitude pulmonary hypertension (HAPH). Although a significant fraction of the population is unaffected, there are susceptible individuals who display HAPH in the absence of any lung, cardiac or hematologic disease. We report herein the analysis of the whole-genome sequencing of healthy individuals compared with HAPH patients and other controls (total n = 33). Read More

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http://www.nature.com/articles/s41431-018-0270-8
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http://dx.doi.org/10.1038/s41431-018-0270-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303266PMC
January 2019
5 Reads
4.350 Impact Factor

Mutations in the ENG, ACVRL1, and SMAD4 genes and clinical manifestations of hereditary haemorrhagic telangiectasia: experience from the Center for Osler's Disease, Uppsala University Hospital.

Ups J Med Sci 2018 Sep 25;123(3):153-157. Epub 2018 Sep 25.

a Department of Haematology , Uppsala University Hospital , Uppsala , Sweden.

Aim: The aim of this retrospective single-centre study was to evaluate whether mutations in the ENG, ACVRL1, and SMAD4 genes were associated with different phenotypes in hereditary haemorrhagic telangiectasia (HHT).

Methods: The case records of 21 HHT patients with verified mutations in ENG, ACVRL1, or SMAD4 genes were reviewed. The numbers of HHT diagnostic criteria fulfilled for the three genotypes were compared, as was the prevalence of complications such as iron deficiency anaemia, gastrointestinal haemorrhage, stroke, and cerebral abscess. Read More

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http://dx.doi.org/10.1080/03009734.2018.1483452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198721PMC
September 2018
1 Read

"Rebound" hypercoagulability after interruption of anticoagulation in patients with atrial fibrillation.

Int J Cardiol 2018 11;271:119

Department of Geriatrics, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, No. 17, Lu Jiang Road, Hefei 230061, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.04.123DOI Listing
November 2018
19 Reads

Immune-Thrombotic Thrombocytopenic Purpura is a Rare Cause of Ischemic Stroke in Young Adults: Case Reports and Literature Review.

J Stroke Cerebrovasc Dis 2018 Nov 12;27(11):3163-3171. Epub 2018 Sep 12.

Department of Neurology, CHU de Bordeaux, Bordeaux, France / Except Yahsou Delmas: Department of Nephrology, CHU de Bordeaux, Bordeaux, France.

Introduction: Immune thrombotic thrombocytopenic purpura (i-TTP), related to acquired ADAMTS-13 dysfunction, can lead to various neurological symptoms including ischemic stroke. To date the clinical, radiological, and biological characteristics of patients having a stroke as the inaugural manifestation of i-TTP are largely unknown.

Methods: Probable immune-TTP was defined by a low ADAMTS-13 activity associated with the presence of ADAMTS-13 inhibitors and/or favorable clinicobiological response under immunological treatments. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.07.017DOI Listing
November 2018
2 Reads

Utilizing Whole-Exome Sequencing to Characterize the Phenotypic Variability of Sickle Cell Disease.

Genet Test Mol Biomarkers 2018 Sep 5;22(9):561-567. Epub 2018 Sep 5.

4 Department of Pediatrics, King Abdullah Specialist Children's Hospital , King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia .

Background: Sickle cell disease (SCD) is a monogenic disease that has wide variety of phenotypes with both and environmental factors contributing to its severity.

Methods: We performed whole-exome sequencing (WES) in 22 Saudi SCD patients to identify variants that could explain differences in disease phenotypes. All variants, except those that were benign and likely benign, described in the ClinVar database, were considered in our analysis. Read More

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https://www.liebertpub.com/doi/10.1089/gtmb.2018.0058
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http://dx.doi.org/10.1089/gtmb.2018.0058DOI Listing
September 2018
17 Reads

Characteristics of methotrexate-induced stroke-like neurotoxicity.

Int J Hematol 2018 Dec 4;108(6):630-636. Epub 2018 Sep 4.

Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.

Intrathecal administration of methotrexate (IT-MTX) can lead to neurotoxicity. MTX-induced neurotoxicity occasionally manifests with a stroke-like presentation that is difficult to distinguish from genuine stroke. We retrospectively reviewed records of nine patients with leukemia or lymphoma and episodes of stroke-like presentation at our institute between 2010 and 2015 for whom magnetic resonance imaging (MRI) data were available. Read More

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http://dx.doi.org/10.1007/s12185-018-2525-0DOI Listing
December 2018
10 Reads

Global Mortality From Firearms, 1990-2016.

Authors:
Mohsen Naghavi Laurie B Marczak Michael Kutz Katya Anne Shackelford Megha Arora Molly Miller-Petrie Miloud Taki Eddine Aichour Nadia Akseer Rajaa M Al-Raddadi Khurshid Alam Suliman A Alghnam Carl Abelardo T Antonio Olatunde Aremu Amit Arora Mohsen Asadi-Lari Reza Assadi Tesfay Mehari Atey Leticia Avila-Burgos Ashish Awasthi Beatriz Paulina Ayala Quintanilla Suzanne Lyn Barker-Collo Till Winfried Bärnighausen Shahrzad Bazargan-Hejazi Masoud Behzadifar Meysam Behzadifar James R Bennett Ashish Bhalla Zulfiqar A Bhutta Arebu Issa Bilal Guilherme Borges Rohan Borschmann Alexandra Brazinova Julio Cesar Campuzano Rincon Félix Carvalho Carlos A Castañeda-Orjuela Lalit Dandona Rakhi Dandona Paul I Dargan Diego De Leo Samath Dhamminda Dharmaratne Eric L Ding Huyen Phuc Do David Teye Doku Kerrie E Doyle Tim Robert Driscoll Dumessa Edessa Ziad El-Khatib Aman Yesuf Endries Alireza Esteghamati Andre Faro Farshad Farzadfar Valery L Feigin Florian Fischer Kyle J Foreman Richard Charles Franklin Nancy Fullman Neal D Futran Tsegaye Tewelde Gebrehiwot Reyna Alma Gutiérrez Nima Hafezi-Nejad Hassan Haghparast Bidgoli Gessessew Bugssa Hailu Josep Maria Haro Hamid Yimam Hassen Caitlin Hawley Delia Hendrie Martha Híjar Guoqing Hu Olayinka Stephen Ilesanmi Mihajlo Jakovljevic Spencer L James Sudha Jayaraman Jost B Jonas Amaha Kahsay Amir Kasaeian Peter Njenga Keiyoro Yousef Khader Ibrahim A Khalil Young-Ho Khang Jagdish Khubchandani Aliasghar Ahmad Kiadaliri Christian Kieling Yun Jin Kim Soewarta Kosen Kristopher J Krohn G Anil Kumar Faris Hasan Lami Van C Lansingh Heidi Jane Larson Shai Linn Raimundas Lunevicius Hassan Magdy Abd El Razek Muhammed Magdy Abd El Razek Reza Malekzadeh Deborah Carvalho Malta Amanda J Mason-Jones Richard Matzopoulos Peter T N Memiah Walter Mendoza Tuomo J Meretoja Haftay Berhane Mezgebe Ted R Miller Shafiu Mohammed Maziar Moradi-Lakeh Rintaro Mori Devina Nand Cuong Tat Nguyen Quyen Le Nguyen Dina Nur Anggraini Ningrum Felix Akpojene Ogbo Andrew T Olagunju George C Patton Michael R Phillips Suzanne Polinder Farshad Pourmalek Mostafa Qorbani Afarin Rahimi-Movaghar Vafa Rahimi-Movaghar Mahfuzar Rahman Rajesh Kumar Rai Chhabi Lal Ranabhat David Laith Rawaf Salman Rawaf Ali Rowhani-Rahbar Mahdi Safdarian Saeid Safiri Rajesh Sagar Joseph S Salama Juan Sanabria Milena M Santric Milicevic Rodrigo Sarmiento-Suárez Benn Sartorius Maheswar Satpathy David C Schwebel Soraya Seedat Sadaf G Sepanlou Masood Ali Shaikh Nigussie Tadesse Sharew Ivy Shiue Jasvinder A Singh Mekonnen Sisay Vegard Skirbekk Adauto Martins Soares Filho Dan J Stein Mark Andrew Stokes Mu'awiyyah Babale Sufiyan Mamta Swaroop Bryan L Sykes Rafael Tabarés-Seisdedos Fentaw Tadese Bach Xuan Tran Tung Thanh Tran Kingsley Nnanna Ukwaja Tommi Juhani Vasankari Vasily Vlassov Andrea Werdecker Pengpeng Ye Paul Yip Naohiro Yonemoto Mustafa Z Younis Zoubida Zaidi Maysaa El Sayed Zaki Simon I Hay Stephen S Lim Alan D Lopez Ali H Mokdad Theo Vos Christopher J L Murray

JAMA 2018 08;320(8):792-814

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

Importance: Understanding global variation in firearm mortality rates could guide prevention policies and interventions.

Objective: To estimate mortality due to firearm injury deaths from 1990 to 2016 in 195 countries and territories.

Design, Setting, And Participants: This study used deidentified aggregated data including 13 812 location-years of vital registration data to generate estimates of levels and rates of death by age-sex-year-location. Read More

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http://dx.doi.org/10.1001/jama.2018.10060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143020PMC
August 2018
16 Reads
35.290 Impact Factor

Statin-induced myopathy prevented by creatine administration.

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Clinica Neurologica, Università degli Studi di Genova, Dipartimento di Neuroscienze Riabilitazione Oftalmologia Genetica e Scienze Materno-Infantili (DINOGMI), Genova, Italy.

A 66-year-old woman with chronic myeloid leukaemia in nilotinib-induced remission was diagnosed with amaurosis fugax, caused by carotid stenosis. Serum cholesterol was 316 mg/dL (Low-Density Lipoprotein (LDL) cholesterol 213 mg/dL). Nilotinib was discontinued and replaced by interferon. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22539
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http://dx.doi.org/10.1136/bcr-2018-225395DOI Listing
August 2018
13 Reads

Cerebral Venous Malformations in a Chinese Population: Clinical Manifestations, Radiological Characteristics, and Long-Term Prognosis.

World Neurosurg 2018 Dec 25;120:e472-e479. Epub 2018 Aug 25.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.

Objective: We elucidated the clinical and radiological characteristics and analyzed the risk factors for hemorrhage and poor outcomes of cerebral venous malformations (CVMs) in a northern Chinese population.

Methods: We included 60 consecutive patients with CVM patients in Beijing Tiantan Hospital from January 2011 to February 2018. The clinical manifestations, radiological characteristics, management, and outcomes were elucidated and analyzed. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.106DOI Listing
December 2018
10 Reads

Pro-gastrin-releasing peptide and outcome in patients with heart failure and anaemia: results from the RED-HF study.

ESC Heart Fail 2018 12 25;5(6):1052-1059. Epub 2018 Aug 25.

Department of Medical Biochemistry, Oslo University Hospital Radiumhospitalet, Oslo, Norway.

Aims: Neuroendocrine activation is associated with poor outcome in heart failure (HF). The neuropeptide gastrin-releasing peptide (GRP), derived from the precursor proGRP1-125 (proGRP), has recently been implicated in inflammation and wound repair. We investigated the predictive value of proGRP on clinical outcomes in HF patients with reduced ejection fraction. Read More

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http://dx.doi.org/10.1002/ehf2.12312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300802PMC
December 2018
6 Reads

In-stent thrombosis after carotid artery stenting in a patient with protein C deficiency.

Neurol Sci 2018 Dec 25;39(12):2229-2230. Epub 2018 Aug 25.

Department of Stroke Medicine, Kawasaki Medical School, 577, Matsushima, Kurashiki, Okayama, 701-0192, Japan.

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http://dx.doi.org/10.1007/s10072-018-3544-6DOI Listing
December 2018
2 Reads

An Audit of Thrombophilia Testing in Patients with Ischemic Stroke or Transient Ischemic Attack: The Futility of Testing.

J Stroke Cerebrovasc Dis 2018 Nov 22;27(11):3301-3305. Epub 2018 Aug 22.

Department of Pathology, Division of Transfusion Medicine and Hemostasis, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Objectives: Many patients admitted with an ischemic stroke or transient ischemic attack (TIA) undergo thrombophilia testing. There is limited evidence to support this practice. We examined the effect of thrombophilia testing on management of patients admitted with an ischemic stroke or TIA. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.07.032DOI Listing
November 2018
14 Reads

Fetal vascular malperfusion, an update.

APMIS 2018 Jul;126(7):561-569

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Fetal vascular malperfusion is the most recent term applied to a group of placental lesions indicating reduced or absent perfusion of the villous parenchyma by the fetus. The most common etiology of malperfusion is umbilical cord obstruction leading to stasis, ischemia, and in some cases thrombosis. Other contributing factors may include maternal diabetes, fetal cardiac insufficiency or hyperviscosity, and inherited or acquired thrombophilias. Read More

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http://dx.doi.org/10.1111/apm.12849DOI Listing
July 2018
4 Reads

Platelet count is associated with outcome in cancer patients with stroke.

J Neurooncol 2018 Dec 18;140(3):569-574. Epub 2018 Aug 18.

Research Unit, Instituto Nacional de Cancerología, Mexico City, Mexico.

Introduction: Cerebrovascular disease (CVD) and cancer are among the most common causes of mortality worldwide, preceded only by ischemic heart disease (IHD). Thrombocytopenia was shown to be associated with poor outcomes in IHD and CVD in the general population. This study aimed to assess the relationship of thrombocytopenia with poor outcomes in cancer patients with CVD. Read More

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http://dx.doi.org/10.1007/s11060-018-2982-6DOI Listing
December 2018
16 Reads

Manifestation of anaplasmosis as cerebral infarction: a case report.

BMC Infect Dis 2018 Aug 17;18(1):409. Epub 2018 Aug 17.

Departments of Internal Medicine, College of Medicine, Chosun University, 588 Seosuk-dong, Dong-gu, Gwangju, 61453, Republic of Korea.

Background: Human granulocytic anaplasmosis is a tick-borne zoonotic disease caused by Anaplasma phagocytophilum, an obligate intracellular granulocytotropic bacterium.

Case Presentation: A 70-year-old female patient was admitted with the clinical signs of fever and an altered state of consciousness 1 week after experiencing a tick bite while planting lawn grass. Magnetic resonance imaging, performed at the time of admission, indicated cerebral infarction in the left basal ganglia, whereas increasing immunofluorescence assay antibody titers for A. Read More

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http://dx.doi.org/10.1186/s12879-018-3321-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098650PMC
August 2018
2 Reads

Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery.

Thromb Haemost 2018 Sep 13;118(9):1572-1585. Epub 2018 Aug 13.

Department of Anesthesiology, Duke Perioperative Genomics Program, Duke University Medical Center, Duke University, Durham, North Carolina, United States.

Introduction:  Thrombocytopenia after cardiac surgery independently predicts stroke, acute kidney injury and death. To understand the underlying risks and mechanisms, we analysed genetic variations associated with thrombocytopenia in patients undergoing coronary artery bypass grafting (CABG) surgery.

Materials And Methods:  Study subjects underwent isolated on-pump CABG surgery at Duke University Medical Center. Read More

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http://dx.doi.org/10.1055/s-0038-1667199DOI Listing
September 2018
12 Reads

Possible clinical marker of first attack of HaNDL syndrome (stroke-like mimics) in emergency room: a case report.

Neurol Sci 2018 Nov 4;39(11):2003-2005. Epub 2018 Aug 4.

Headache Centre, Neurosciences Department, Niguarda Ca' Granda Hospital, Milan, Italy.

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http://link.springer.com/10.1007/s10072-018-3517-9
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http://dx.doi.org/10.1007/s10072-018-3517-9DOI Listing
November 2018
1 Read

The Genetic Landscape of Cerebral Steno-Occlusive Arteriopathy and Stroke in Sickle Cell Anemia.

J Stroke Cerebrovasc Dis 2018 Nov 31;27(11):2897-2904. Epub 2018 Jul 31.

Departments of Neurology, University of Washington, Seattle, Washington; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.

Sickle cell disease (SCD) is one of the most common autosomal recessive diseases in humans, occurring at a frequency of 1 in 365 African-American and 1 in 50 sub-Saharan African births. Despite progress in managing complications of SCD, these remain a major health burden worldwide. Stroke is a common and serious complication of SCD, most often associated with steno-occlusive cerebral arteriopathy, but little is known about its pathogenesis. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.06.004DOI Listing
November 2018
3 Reads

Cardiovascular oncology: exploring the effects of targeted cancer therapies on atherosclerosis.

Curr Opin Lipidol 2018 Oct;29(5):381-388

Department of Medical Biochemistry, Subdivision Experimental Vascular Biology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.

Purpose Of Review: Targeted cancer therapies have revolutionized the treatment of cancer in the past decade, but cardiovascular toxicity is a rising problem in cancer patients. Here we discuss the effects of targeted cancer therapies on atherosclerosis. Increasing the awareness of these adverse effects will promote the development of evidence-based preventive strategies in the emerging field of cardiovascular oncology. Read More

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http://dx.doi.org/10.1097/MOL.0000000000000538DOI Listing
October 2018
1 Read

Iron deficiency in chronic heart failure: case-based practical guidance.

ESC Heart Fail 2018 10 2;5(5):764-771. Epub 2018 Aug 2.

Community Heart Failure Programme, Department of Cardiology, Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.

In patients with chronic heart failure, iron deficiency, even in the absence of anaemia, can aggravate the underlying disease and have a negative impact on clinical outcomes and quality of life. The 2016 European Society of Cardiology guidelines for the diagnosis and treatment of acute and chronic heart failure recognize iron deficiency as a co-morbidity in chronic heart failure and recommend iron status screening in all newly diagnosed patients with chronic heart failure. Furthermore, the guidelines specifically recommend considerations of intravenous iron therapy, ferric carboxymaltose, for the treatment of iron deficiency. Read More

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http://dx.doi.org/10.1002/ehf2.12333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165963PMC
October 2018
1 Read

Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews.

Cochrane Database Syst Rev 2018 08 1;8:CD012082. Epub 2018 Aug 1.

5639 Gowland Rd., Sechelt, BC, Canada, V0N 3A8.

Background: Globally, sickle cell disease (SCD) is one of the commonest severe monogenic disorders, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Red blood cell (RBC) transfusions are used to treat complications of SCD, e. Read More

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http://dx.doi.org/10.1002/14651858.CD012082.pub2DOI Listing
August 2018
1 Read

Novel KRIT1/CCM1 heterozygous nonsense mutation (c.715 C>T) associated with cerebral and cerebellar cavernous malformations in a paediatric patient.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA.

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http://dx.doi.org/10.1136/bcr-2018-226246DOI Listing
July 2018
1 Read

Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler Study.

J Stroke Cerebrovasc Dis 2018 Oct 24;27(10):2703-2706. Epub 2018 Jul 24.

Disciplina de Neurologia Clínica, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil; Programa Integrado de Neurologia, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil.

Background: Impairment of vasodilatory capacity reflecting reduced cerebrovascular reserve was previously shown in adults with sickle cell disease (SCD) and might play a role in the pathophysiology of stroke in such patients. We examined the hypothesis that children with SCD would also have a higher frequency of impaired cerebral vasoreactivity when compared with healthy age- and gender-matched controls.

Methods: Patients were recruited from our hematology outpatient clinic. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.05.042DOI Listing
October 2018

Causes of death in Japanese patients with atrial fibrillation: The Fushimi Atrial Fibrillation Registry.

Eur Heart J Qual Care Clin Outcomes 2019 01;5(1):35-42

Department of Cardiology, National Hospital Organization Kyoto Medical Center, 1-1, Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, Japan.

Aims: To investigate the causes of death and the associated clinical factors in patients with atrial fibrillation (AF) in the contemporary clinical practice.

Methods And Results: The Fushimi AF Registry is a community-based prospective survey of AF patients since March 2011 in Fushimi-ku, Kyoto. We investigated causes of death and the clinical indicators of cardiovascular (CV) and non-CV death in 4045 patients with available follow-up data by the end of November 2016. Read More

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https://academic.oup.com/ehjqcco/advance-article/doi/10.1093
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http://dx.doi.org/10.1093/ehjqcco/qcy033DOI Listing
January 2019
22 Reads

Balance control is impaired in adults with sickle cell anaemia.

Somatosens Mot Res 2018 06 16;35(2):109-118. Epub 2018 Jul 16.

a Rehabilitation Sciences Master's Programme , Augusto Motta University Center , Rio de Janeiro , Brazil.

Background: Musculoskeletal involvement and cerebrovascular disease are common in sickle cell anaemia (SCA). These changes are potentially important factors that modify the control of balance in this population.

Objective: To assess balance control in adults with SCA and investigate the associations among balance, posture and muscle function. Read More

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http://dx.doi.org/10.1080/08990220.2018.1481829DOI Listing
June 2018
14 Reads
0.580 Impact Factor

The comorbidity of acute ischemic stroke and splenic infarction resulting from essential thrombocythemia.

Neurol Sci 2018 10 8;39(10):1787-1790. Epub 2018 Jul 8.

Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

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http://dx.doi.org/10.1007/s10072-018-3462-7DOI Listing
October 2018
1 Read

Giant cavernous malformations: A single center experience and literature review.

J Clin Neurosci 2018 Oct 6;56:108-113. Epub 2018 Jul 6.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, NO. 6 Tiantan Xili, Dongcheng District, Beijing 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing, PR China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, PR China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, PR China. Electronic address:

Intracranial giant cavernous malformations (GCMs) are rarely reported because of their extremely low incidence. Knowledge of GCM is poor. The goals of this study were to analyze the epidemiological characteristics, clinical manifestations, radiological findings, microsurgical treatment, and neurological outcomes of GCMs. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.06.042DOI Listing
October 2018
2 Reads
1.320 Impact Factor

Cardiac output response to exercise in patients before allogenic hematopoietic stem cell transplantation.

Int J Clin Oncol 2018 Dec 5;23(6):1173-1177. Epub 2018 Jul 5.

Department of Rehabilitation, Kanazawa University Hospital, Takaramachi 13-1, Kanazawa, Ishikawa, 920-8641, Japan.

Introduction: High-dose chemotherapy for remission induction can induce cardiac toxicity prior to hematopoietic stem cell transplantation (HSCT). However, the details of cardiac function in patients undergoing HSCT are unclear, particularly during exercise. The aim of present study was to evaluate cardiac output responses to exercise in patients after high-dose chemotherapy before HSCT compared with in age-matched healthy controls. Read More

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http://dx.doi.org/10.1007/s10147-018-1315-2DOI Listing
December 2018
6 Reads

Deficiency of Adenosine Deaminase 2 in Adult Siblings: Many Years of a Misdiagnosed Disease With Severe Consequences.

Front Immunol 2018 14;9:1361. Epub 2018 Jun 14.

National Human Genome Research Institute, National Institute of Health, Bethesda, MD, United States.

Objective: Describe the clinical characteristics and histopathology findings in a family with two siblings affected with deficiency of adenosine deaminase 2 (DADA2). Both patients presented in childhood with polyarthritis and developed significant neurological and gastrointestinal features of DADA2 in ear, including variable degrees of immunologic and hematologic manifestations.

Methods: Adenosine Deaminase 2 (ADA2; also known as exon sequencing and serum ADA2 levels were performed to confirm the diagnosis of DADA2. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010516PMC
June 2018
2 Reads