4,832 results match your criteria Blood Dyscrasias and Stroke


Network meta-analysis: a new analysis tool of the experimental evidence.

Minerva Med 2019 Apr;110(2):173-175

Department of Geriatrics, "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Foggia, Italy.

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http://dx.doi.org/10.23736/S0026-4806.18.05768-3DOI Listing
April 2019
2 Reads

Mixed cerebrovascular disease in an elderly patient with mixed vascular risk factors: a case report.

BMC Neurol 2019 Feb 12;19(1):26. Epub 2019 Feb 12.

Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.

Background: Mixed cerebrovascular disease is a diagnostic entity that presents with hemorrhagic and ischemic stroke clinically and/or subclinically. Here, we report a patient with mixed vascular risk factors, who presented with multiple intracerebral hemorrhages and a simultaneously occurring cerebral infarction with hemorrhagic transformation.

Case Presentation: A 63-year-old male with no history of trauma or prior neurological disease presented with a sudden onset of weakness in his right limbs, followed by an episode of focal seizure without impaired awareness. Read More

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http://dx.doi.org/10.1186/s12883-019-1248-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371517PMC
February 2019
6 Reads

[Establishment of Flow Cytometric Immunobead Array for Detecting Plasma Von Willebrand Factor Activity and Its Clinical Application in the Prognosis of Ischemic Stroke].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Feb;27(1):208-214

The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou 215006, Jiangsu Province, China.

Objective: To establish a novel flow cytometric immunobead array (FCIA) for detecting plasma von Willebrand factor activity (vWF:GPIbR) and apply it in ischemic stroke (IS).

Methods: Microspheres coated with anti-human platelet glycoprotein Ibα (GPIbα) monoclonal antibody SZ151 IgG, were incubated with recombinant fragment of GPIbα, then added ristocetin and plasma, finally incubated with FITC-conjugated sheep-anti-human vWF IgG polyclonal antibody, and detected by flow cytometry. vWF antigen (vWF:Ag), vWF:GPIbR, and vWF collagen binding assay (vWF:CB) were also included for evaluating vWF levels in IS patients. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2019.01.034DOI Listing
February 2019
2 Reads

Acute ischemic stroke in the setting of essential thrombocytemia (clinical cases).

Ter Arkh 2018 Aug;90(7):102-104

National Research Center of Hematology, Moscow, Russia.

This article describes several clinical cases of acute ischemic stroke among patients suffering from essential thrombocytemia. Ambiguity of etiological factors of stroke is demonstrated among patients with this pathology. Thrombocytosis and high allele load in the Jak2 gene play an important role (even with normal platelet count) in progression of cerebrovascular disease. Read More

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http://dx.doi.org/10.26442/terarkh2018907102-104DOI Listing
August 2018
2 Reads

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial.

JAMA 2019 02;321(6):553-561

National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Importance: There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia.

Objective: To evaluate the effect of intensive blood pressure control on risk of dementia.

Design, Setting, And Participants: Randomized clinical trial conducted at 102 sites in the United States and Puerto Rico among adults aged 50 years or older with hypertension but without diabetes or history of stroke. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.21442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439590PMC
February 2019
59 Reads

Association of Matched Sibling Donor Hematopoietic Stem Cell Transplantation With Transcranial Doppler Velocities in Children With Sickle Cell Anemia.

JAMA 2019 01;321(3):266-276

Department of Statistics, Saint-Louis Hospital, ECSTRA Team, UMR1153, INSERM, University Paris-Diderot, Paris, France.

Importance: In children with sickle cell anemia (SCA), high transcranial Doppler (TCD) velocities are associated with stroke risk, which is reduced by chronic transfusion. Whether matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) can reduce velocities in patients with SCA is unknown.

Objective: To determine the association of MSD-HSCT with TCD velocities as a surrogate for the occurrence of ischemic stroke in children with SCA. Read More

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http://dx.doi.org/10.1001/jama.2018.20059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439675PMC
January 2019
20 Reads

Matched Sibling Donor Hematopoietic Stem Cell Transplantation to Prevent Stroke in Children With Sickle Cell Anemia.

JAMA 2019 01;321(3):251-252

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1001/jama.2018.20390DOI Listing
January 2019
2 Reads

Endovascular Treatment of Cerebral Venous Sinus Thrombosis and Insights into Intracranial Coagulopathy.

J Stroke Cerebrovasc Dis 2019 Apr 8;28(4):e7-e9. Epub 2019 Jan 8.

Columbia University, Vagelos College of Physicians & Surgeons, New York, New York.

Cerebral venous sinus thrombosis (CVST) requires anticoagulation to promote vessel recanalization. Current anticoagulation paradigms utilize plasma tests from peripheral venous/arterial samples for therapeutic monitoring. We describe a medically-refractory case of CVST in a 35-year-old woman later found to have JAK2 mutation and essential thrombocytosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183071
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441363PMC
April 2019
16 Reads

Sticky Platelet Syndrome: 35 Years of Growing Evidence.

Semin Thromb Hemost 2019 Feb 10;45(1):61-68. Epub 2019 Jan 10.

Department of Haematology and Transfusion Medicine, National Centre of Haemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, Slovakia.

Since the identification of antithrombin deficiency by Egeberg in 1956, ongoing research in prothrombotic defects continues to progress. Interestingly, past research has predominantly focused on coagulation factors and not on other components of the hemostatic system. The possible role of platelet function defects in the development of thrombotic events was suggested for the first time in the late 1970s, when an increased platelet adhesiveness and aggregation after epinephrine (EPI) and adenosine diphosphate (ADP) was found in a group of patients with unexplained transient ischemic attack. Read More

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http://dx.doi.org/10.1055/s-0038-1676581DOI Listing
February 2019
2 Reads

Sickle cell disease: Translating clinical care to low-resource countries through international research collaborations.

Semin Hematol 2018 04 26;55(2):102-112. Epub 2018 Apr 26.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; University of Cincinnati College of Medicine, Cincinnati, OH. Electronic address:

The vast majority of the world's population of children and adults with sickle cell disease (SCD) are born in low-resource settings, particularly in sub-Saharan Africa, the Caribbean, the Middle East, and India. As a result numerous well-established, cost-effective, and evidence-based strategies for managing SCD such as newborn screening, early education, vaccinations, screening for stroke prevention, and treatments with safe transfusions and hydroxyurea are often unavailable, leading to substantial morbidity and increased mortality. Collaborations between high-income countries and these low-resource settings (North-South partnerships) have been advocated, with the goal of improving clinical care. Read More

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http://dx.doi.org/10.1053/j.seminhematol.2018.04.010DOI Listing
April 2018
3 Reads

Sensorineural hearing loss in children with sickle cell disease.

Int J Pediatr Otorhinolaryngol 2019 Mar 5;118:110-114. Epub 2018 Dec 5.

Emory University School of Medicine, 1648 Pierce Drive NE, Atlanta, GA, 30307, USA; Children's Healthcare of Atlanta, Department of Otolaryngology, Division of Pediatric Otolaryngology, 2015 Uppergate Drive, Atlanta, GA, 30322, USA.

Introduction: Sensorineural hearing loss (SNHL) has been reported to occur at increased frequency in the pediatric sickle cell disease (SCD) population, likely secondary to ototoxic medication regimens and repeat sickling events that lead to end organ damage. Risk and protective factors of SNHL in this population are not fully characterized. The objective of this study was to describe audiology results in children with SCD and the prevalence and sequelae of SNHL. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183060
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http://dx.doi.org/10.1016/j.ijporl.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443092PMC
March 2019
16 Reads

Clinical Impact of Thrombophilia Screening in Young Adults with Ischemic Stroke.

J Stroke Cerebrovasc Dis 2019 Apr 27;28(4):882-889. Epub 2018 Dec 27.

Department of Neurology, Weill Cornell Medicine, New York, New York; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York. Electronic address:

Objective: We evaluated the ability of genetic and serological testing to diagnose clinically relevant thrombophilias in young adults with ischemic stroke.

Methods: We performed a retrospective cohort study of patients aged 18-65 years diagnosed with acute ischemic stroke at a comprehensive stroke center between 2011 and 2015 with laboratory testing for thrombophilia. The primary outcome was any positive thrombophilia screening test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183070
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441373PMC
April 2019
7 Reads

Recurrent Stroke in a Ghanaian Patient With Polycythemia.

J Stroke Cerebrovasc Dis 2019 Mar 27;28(3):850-852. Epub 2018 Dec 27.

University of California, San Francisco, California.

Background: Polycythemia is a rare but important preventable cause of stroke with potential for recurrence when not identified and appropriately managed.

Case Presentation: This is a case of a 55-year-old Ghanaian who presented to our tertiary facility after a 2-month delay with a history of sudden onset of right-sided hemiparesis and expressive aphasia. He had suffered a previous stroke with left hemiparesis 2 years previously where hypertension and polycythemia were identified and treatment initiated. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.032DOI Listing
March 2019
2 Reads

Prevalence, risk factors, and significance of iron deficiency and anemia in nonischemic heart failure patients with reduced ejection fraction from a Himachal Pradesh heart failure registry.

Indian Heart J 2018 Dec 2;70 Suppl 3:S182-S188. Epub 2018 Nov 2.

IGMC Shimla, HP, India.

Background: The study aimed to estimate the prevalence, risk determinants, and its clinical significance of iron deficiency and anemia in patients of nonischemic heart failure with reduced ejection fraction (HFrEF).

Methods: Serum ferritin, transferrin saturation, and the hemoglobin (Hb) levels were measured in 226 consecutive patients with HFrEF diagnosed based on the left ventricular ejection fraction ≤ 45% and absence of coronary artery luminal narrowing of more than 50%, in a prospective tertiary care hospital-based heart failure registry. Patients with the New York Heart Association functional class III/IV were classified as patients with advanced heart failure. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310070PMC
December 2018
3 Reads

A case report of cerebral infarction caused by polycythemia vera.

Medicine (Baltimore) 2018 Dec;97(52):e13880

Department of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.

Rationale: Polycythemia vera (PV) is a cloned erythrocytotic disease manifested by high proliferation and apoptosis in the bone marrow. The clinical symptoms of PV are occult. In practice, patients with cerebral infarction caused by PV are prone to misdiagnosis and missed diagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314744PMC
December 2018
5 Reads

Acute on chronic anaemia with a haemoglobin of 18 g/L (1.8 g/dL) and haematocrit of 7.2.

BMJ Case Rep 2018 Dec 22;11(1). Epub 2018 Dec 22.

Internal Medicine Residency Program, Southeast Health, Dothan, Alabama, USA.

Anaemia can present with symptoms of fatigue, shortness of breath, weakness, malaise, tachycardia and skin pallor. If left untreated, this can progress to life-threatening complications such as arrhythmias, cardiac hypertrophy and myocardial infarction. In this report, a 43-year-old woman, who was ambulatory with no exertional dysponea, presented with weakness, fatigue, bilateral lower extremity oedema and intermittent right sided chest pain for several months. Read More

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http://dx.doi.org/10.1136/bcr-2018-226000DOI Listing
December 2018
4 Reads

A Case of Multiple Cerebral Infarction Preceding Acute Exacerbation of Idiopathic Thrombocytopenic Purpura.

J Stroke Cerebrovasc Dis 2019 Mar 13;28(3):789-791. Epub 2018 Dec 13.

Department of Neurology, Yokohama Rosai Hospital, Yokohama, Kanagawa, Japan.

Background: Although it was suggested that idiopathic thromobocytopenic purpura (ITP) can be a paradoxical cause of cerebral infarction, previous reports indicate that cerebral infarction associated with ITP occurs when thrombocytopenia is already evident at the onset of cerebral infarction.

Case Report: We report a case of multiple cerebral infarction that preceded acute exacerbation of ITP. An 80-year-old woman with a history of ITP presented with tetraplegia, and brain magnetic resonance imaging revealed multiple infarction in bilateral cerebral and cerebellar hemispheres. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.026DOI Listing

Use of Measures of Inflammation and Kidney Function for Prediction of Atherosclerotic Vascular Disease Events and Death in Patients With CKD: Findings From the CRIC Study.

Am J Kidney Dis 2019 Mar 10;73(3):344-353. Epub 2018 Dec 10.

Division of Kidney Diseases and Hypertension, George Washington University, Washington, DC. Electronic address:

Rationale & Objective: Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney disease (CKD). We sought to determine whether the addition of measures of inflammation and kidney function to traditional estimation tools improves prediction of these events in a diverse cohort of patients with CKD.

Study Design: Observational cohort study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.09.012DOI Listing
March 2019
2 Reads
5.900 Impact Factor

Adult and pediatric mechanical circulation: a guide for the hematologist.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):507-515

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Mechanical circulatory support (MCS) is the overarching term that encompasses the temporary and durable devices used in patients with severe heart failure. MCS disturbs the hematologic and coagulation system, leading to platelet activation, activation of the contact pathway of coagulation, and acquired von Willebrand syndrome. Ischemic stroke and major hemorrhage occur in up to 30% of patients. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245997PMC
November 2018
2 Reads

Paradoxical Thromboembolic Ischemic Stroke and Pulmonary Embolism after Uterine Fibroid Embolization.

J Vasc Interv Radiol 2018 12;29(12):1772-1775.e2

Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB T2N2T9, Canada; Department of Critical Care Medicine, University of Calgary, Calgary, AB T2N2T9, Canada.

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http://dx.doi.org/10.1016/j.jvir.2018.06.026DOI Listing
December 2018
6 Reads

Prevalence of comorbidities in systemic sclerosis versus rheumatoid arthritis: a comparative, multicenter, matched-cohort study.

Arthritis Res Ther 2018 Dec 4;20(1):267. Epub 2018 Dec 4.

Joint Rheumatology Program, 1st Department of Propedeutic Internal Medicine-Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens, Greece.

Background: Comorbidities are common in chronic systemic connective tissue diseases and are associated with adverse outcomes, increased morbidity and mortality. Although the prevalence of comorbidities has been well-studied in isolated diseases, comparative studies between different autoimmune diseases are limited. In this study, we compared the prevalence of common comorbidities between patients with systemic sclerosis (SSc) and patients with rheumatoid arthritis (RA). Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1771-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280404PMC
December 2018
24 Reads

Investigating the ability of non-invasive measures of cardiac output to detect a reduction in blood volume resulting from venesection in spontaneously breathing subjects.

Scand J Trauma Resusc Emerg Med 2018 Dec 4;26(1):104. Epub 2018 Dec 4.

Emergency Department, Royal London Hospital, Barts Health NHS Trust, London, UK.

Background: Monitoring cardiac output (CO) in shocked patients provides key etiological information and can be used to guide fluid resuscitation to improve patient outcomes. Previously this relied on invasive monitoring, restricting its use in the Emergency Department (ED) setting. The development of non-invasive devices (such as LiDCOrapid with CNAP™ and USCOM 1A), and ultrasound based measurements (Transthoracic echocardiography, inferior vena cava collapsibility index (IVCCI), carotid artery blood flow (CABF) and carotid artery corrected flow time (FTc)) enables stroke volume (SV) and CO to be measured non-invasively in the ED. Read More

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https://sjtrem.biomedcentral.com/articles/10.1186/s13049-018
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http://dx.doi.org/10.1186/s13049-018-0571-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280441PMC
December 2018
6 Reads

Surgical Revascularization for Pediatric Patients with Sickle Cell Disease and Moyamoya Disease in the Prevention of Ischemic Strokes: A Single-Center Case Series and a Systematic Review.

World Neurosurg 2019 Mar 26;123:435-442.e8. Epub 2018 Nov 26.

Division of Pediatric Neurosurgery, University of Florida Health Jacksonville, Jacksonville, Florida, USA. Electronic address:

Background: This systematic review aims to identify and analyze the available evidence on the safety and efficacy of surgical revascularization for pediatric patients with sickle cell disease (SCD) and moyamoya disease (MMD).

Methods: A systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The following databases were searched: PubMed, Ovid MEDLINE, and Scopus. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.157DOI Listing
March 2019
2 Reads

Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke.

World J Gastroenterol 2018 Nov;24(43):4950-4958

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Province, China.

Aim: To investigate the specific biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke (CRCIS).

Methods: A retrospective study was conducted on CRCIS patients (colorectal cancer patients with ischemic stroke without conventional stroke risk factors) registered at seven centers between January 2007 and December 2017. Clinical data and laboratory and imaging findings were compared with age- and sex- matched patients with colorectal cancer (CRC) without ischemic stroke that were admitted to the same hospital during the same period. Read More

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http://dx.doi.org/10.3748/wjg.v24.i43.4950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250925PMC
November 2018
2 Reads

Impact of anemia on percutaneous coronary intervention in Chinese patients: A large single center data.

J Interv Cardiol 2018 Dec 22;31(6):826-833. Epub 2018 Nov 22.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Objectives: To investigate the impact of anemia on 2-year outcomes in patients undergoing contemporary percutaneous coronary intervention (PCI).

Background: Whether anemia is an independent predictor of adverse outcomes after PCI is under debate.

Methods: A total of 10 717 consecutive patients who underwent PCI with available hemoglobin values at Fuwai Hospital were collected. Read More

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http://dx.doi.org/10.1111/joic.12570DOI Listing
December 2018
5 Reads

Fetal stroke and cerebrovascular disease: Advances in understanding from lenticulostriate and venous imaging, alloimmune thrombocytopaenia and monochorionic twins.

Eur J Paediatr Neurol 2018 Nov 11;22(6):989-1005. Epub 2018 Sep 11.

Departments of Child Health, Obstetrics and Gynaecology and Radiology, University Hospital Southampton, United Kingdom; Clinical and Experimental Sciences, University of Southampton, United Kingdom.

Fetal stroke is an important cause of cerebral palsy but is difficult to diagnose unless imaging is undertaken in pregnancies at risk because of known maternal or fetal disorders. Fetal ultrasound or magnetic resonance imaging may show haemorrhage or ischaemic lesions including multicystic encephalomalacia and focal porencephaly. Serial imaging has shown the development of malformations including schizencephaly and polymicrogyra after ischaemic and haemorrhagic stroke. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.08.008DOI Listing
November 2018
15 Reads

Plasma Phospholipid Transfer Protein Promotes Platelet Aggregation.

Thromb Haemost 2018 Dec 12;118(12):2086-2097. Epub 2018 Nov 12.

Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, United States.

It remains unclear whether plasma phospholipid transfer protein (PLTP) is involved in hyper-coagulation or hypo-coagulation. This study investigated the direct effect of PLTP on platelet aggregation and the underlying mechanism. Washed platelets from humans or mice and mouse platelet-rich plasma and human recombinant PLTP were isolated. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1675228
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http://dx.doi.org/10.1055/s-0038-1675228DOI Listing
December 2018
7 Reads

Hemichorea associated with cavernous angioma and a small errhysis: A case report and literature review.

Medicine (Baltimore) 2018 Oct;97(43):e12889

Departments of Neurosurgery.

Rationale: Chorea is a movement disorder characterized by randomly appearing involuntary movements of the face, neck, limbs, or trunk. Hemichorea is unilateral, involving one side of the body. Hemichorea is commonly caused by non-ketotic hyperglycemia and/or cerebrovascular injury to the contralateral basal ganglia. Read More

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http://dx.doi.org/10.1097/MD.0000000000012889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221695PMC
October 2018
1 Read

Angiotensinogen M235T Gene Polymorphism is a Genetic Determinant of Cerebrovascular and Cardiopulmonary Morbidity in Adolescents with Sickle Cell Disease.

J Stroke Cerebrovasc Dis 2019 Feb 5;28(2):441-449. Epub 2018 Nov 5.

Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address:

Background: Cerebrovascular stroke is a common critical complication of sickle cell disease (SCD). Angiotensinogen (AGT) M235T gene polymorphism is associated with risk of ischemic stroke and cardiovascular disease.

Aim: We investigated the potential association between angiotensinogen M235T gene polymorphism and susceptibility to cerebrovascular and cardiopulmonary complications in adolescents with SCD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183059
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.019DOI Listing
February 2019
63 Reads
1.993 Impact Factor

Indwelling ports for prophylactic RBC exchanges in sickle cell patients: Comparison of bard and vortex ports.

J Clin Apher 2018 Dec 2;33(6):666-670. Epub 2018 Nov 2.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Introduction: Red blood cell exchange (RCE) procedures are commonly used for stroke prevention in sickle cell disease (SCD) patients. We compared two different dual lumen ports used for RCE because differences between the port and catheter design may lead to functional variance.

Methods: We reviewed the RCE parameters of SCD patients following implantable port placement encountered at a single institution. Read More

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http://dx.doi.org/10.1002/jca.21663DOI Listing
December 2018
1 Read

Recurrent thrombosis after carotid endarterectomy secondary to activated protein C resistance and essential thrombocytosis: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e13118

Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, Ulsan University, Republic of Korea.

Rationale: Thrombosis is a major cause of morbidity in the perioperative period. Although many risk factors are known, activated protein C resistance is a prominent risk for thrombosis. Activated protein C resistance frequently occurs with recurrent thromboembolism. Read More

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http://dx.doi.org/10.1097/MD.0000000000013118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221756PMC
November 2018
7 Reads

Safety of Therapeutic Plasma Exchange for the Treatment of Guillain-Barré Syndrome in Polycythemia Vera.

Neurologist 2018 Nov;23(6):185-187

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York.

Polycythemia vera (PV) is a risk factor for systemic thromboses and ischemic stroke. This has been attributed to blood hyperviscosity, the result of increased blood cell production. Intravenous immunoglobulin, which is indicated for the treatment of numerous hematologic and neurological conditions also causes increased serum viscosity and has been associated with ischemic strokes in the setting of PV. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000197DOI Listing
November 2018
10 Reads

Intravenous Iron in Patients Undergoing Maintenance Hemodialysis.

N Engl J Med 2019 01 26;380(5):447-458. Epub 2018 Oct 26.

From the Department of Renal Medicine, King's College Hospital (I.C.M., C.W.), and University College London (D.C.W.), London, Hull and East Yorkshire Hospitals NHS Trust and Hull York Medical School, Hull (S.B.), Lister Hospital, Stevenage (K.F.), and University of Hertfordshire, Hertfordshire (K.F.), the Department of Renal Medicine, Salford Royal NHS Foundation Trust, Salford (P.A.K.), the British Heart Foundation Cardiovascular Research Centre (J.J.V.M.) and the Robertson Centre for Biostatistics (H.M., I.F.), University of Glasgow, Glasgow, Freeman Hospital, Newcastle upon Tyne (C.R.V.T.), and the Oxford Kidney Unit, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford (C.G.W.) - all in the United Kingdom; and the Division of Cardiology and Metabolism, Department of Cardiology, Berlin-Brandenburg Center for Regenerative Therapies, German Center for Cardiovascular Research partner site Berlin, Charité Universitätsmedizin Berlin, Berlin (S.D.A.).

Background: Intravenous iron is a standard treatment for patients undergoing hemodialysis, but comparative data regarding clinically effective regimens are limited.

Methods: In a multicenter, open-label trial with blinded end-point evaluation, we randomly assigned adults undergoing maintenance hemodialysis to receive either high-dose iron sucrose, administered intravenously in a proactive fashion (400 mg monthly, unless the ferritin concentration was >700 μg per liter or the transferrin saturation was ≥40%), or low-dose iron sucrose, administered intravenously in a reactive fashion (0 to 400 mg monthly, with a ferritin concentration of <200 μg per liter or a transferrin saturation of <20% being a trigger for iron administration). The primary end point was the composite of nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure, or death, assessed in a time-to-first-event analysis. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1810742
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http://dx.doi.org/10.1056/NEJMoa1810742DOI Listing
January 2019
45 Reads

Multiple nodular dural cavernous angiomas occluding superior sagittal sinus and destructing calvarium: Case report and literature review.

J Clin Neurosci 2018 Dec 16;58:218-221. Epub 2018 Oct 16.

Department of Neurosurgery, Peking University International Hospital, Peking University Health Science Center, Beijing 102206, PR China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, PR China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100050, PR China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100050, PR China. Electronic address:

Dural cavernous angiomas (CAs) outside the middle cranial fossa are uncommon vascular lesions that generally present with benign clinical course compared to those within the middle cranial fossa. Aggressive invasion of these lesions is less common and mainly involves the skull. Dura sinus invasion and diffused nodular growth are exceedingly rare. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.10.015DOI Listing
December 2018
3 Reads

Triple therapy: worth the risk?

Minerva Med 2018 Oct;109(5):403-405

Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany -

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https://www.minervamedica.it/index2.php?show=R10Y2018N05A040
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http://dx.doi.org/10.23736/S0026-4806.18.05564-7DOI Listing
October 2018
7 Reads

Red blood cell mechanical sensitivity improves in patients with sickle cell disease undergoing chronic transfusion after prolonged, subhemolytic shear exposure.

Transfusion 2018 12 16;58(12):2788-2796. Epub 2018 Oct 16.

Division of Cardiology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

Background: Sickle cell disease (SCD) is a genetically inherited hemoglobinopathy in which deoxygenated hemoglobin S polymerizes, leading to stiff red blood cells (RBCs) and inefficient microcirculatory blood flow. Transfusion therapy acts as primary and secondary prevention of ischemic stroke in SCD. Whether blood transfusion alters the mechanical sensitivity (MS) of RBCs to prolonged subhemolytic shear stress (shear) is unknown. Read More

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http://doi.wiley.com/10.1111/trf.14901
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http://dx.doi.org/10.1111/trf.14901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283667PMC
December 2018
16 Reads

Significant association of anti-platelet factor 4/heparin antibody with cardiovascular disease in hemodialysis patients: a longitudinal 7-year study.

Int Urol Nephrol 2018 Dec 15;50(12):2289-2297. Epub 2018 Oct 15.

Department of Nephrology, Tainan Sinlau Hospital, No. 57, 1 Sec., Dongmen Rd, Tainan, Taiwan.

Background: Hemodialysis patients have a high incidence of anti-platelet factor 4/heparin antibody (PF4-H Ab) and are at a high risk of cardiovascular disease. This study determines the association between PF4-H Ab and cardiovascular events including coronary artery disease (CAD), ischemic stroke (IS), and native arteriovenous fistula thrombosis (AVFT), in a longitudinal 7-year follow-up.

Patients And Methods: 84 hemodialysis patients were enrolled. Read More

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http://link.springer.com/10.1007/s11255-018-2002-y
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http://dx.doi.org/10.1007/s11255-018-2002-yDOI Listing
December 2018
12 Reads

Incidence and impact of cardiorenal anaemia syndrome on all-cause mortality in acute heart failure patients stratified by left ventricular ejection fraction in the Middle East.

ESC Heart Fail 2019 02 12;6(1):103-110. Epub 2018 Oct 12.

Mohammed Bin Khalifa Cardiac Centre, Manama, Bahrain.

Aims: This study aims to evaluate the incidence and impact of cardiorenal anaemia syndrome (CRAS) on all-cause mortality in acute heart failure (AHF) patients stratified by left ventricular ejection fraction (LVEF) status in the Middle East.

Methods And Results: Data were analysed from 4934 consecutive patients admitted to 47 hospitals in seven Middle Eastern countries (Saudi Arabia, Oman, Yemen, Kuwait, United Arab Emirates, Qatar, and Bahrain) with AHF from February to November 2012. CRAS was defined as AHF with estimated glomerular filtration rate of <60 mL/min and low haemoglobin (<13 g/dL for men or <12 g/dL for women). Read More

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http://doi.wiley.com/10.1002/ehf2.12351
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http://dx.doi.org/10.1002/ehf2.12351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352888PMC
February 2019
7 Reads

Screening, diagnosis and treatment of iron deficiency in chronic heart failure: putting the 2016 European Society of Cardiology heart failure guidelines into clinical practice.

Eur J Heart Fail 2018 12 12;20(12):1664-1672. Epub 2018 Oct 12.

Community Heart Failure Program, Department of Cardiology, University of Barcelona, Bellvitge University Hospital and IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.

Iron deficiency is common in patients with chronic heart failure (CHF) and is associated with reduced exercise performance, impaired health-related quality of life and an increased risk of mortality, irrespective of whether or not anaemia is present. Iron deficiency is a serious but treatable condition. Several randomized controlled clinical trials have demonstrated the ability of intravenous (IV) iron, primarily IV ferric carboxymaltose (FCM), to correct iron deficiency in patients with heart failure with reduced ejection fraction (HFrEF), resulting in improvements in exercise performance, CHF symptoms and health-related quality of life. Read More

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http://dx.doi.org/10.1002/ejhf.1305DOI Listing
December 2018
4 Reads

Increased Risk of Ischemic Stroke in Multiple Myeloma Associated With Lenalidomide Treatment: A Case Report and Review of the Literature.

Clin Neuropharmacol 2018 Nov/Dec;41(6):232-235

Department of Neurology and Stroke Center, La Paz University Hospital, Autonomous University of Madrid, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain.

Objective: The aim of the study was to illustrate the increased risk of ischemic stroke in the context of multiple myeloma (MM) under treatment with lenalidomide combined with dexamethasone.

Methods: This is a case report and literature review.

Results: A 62-year-old woman diagnosed with relapsed MM under treatment with lenalidomide and dexamethasone presented with acute onset disorientation, disturbed behavior, and aphasia. Read More

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http://dx.doi.org/10.1097/WNF.0000000000000310DOI Listing
December 2018
28 Reads

Association of anemia and hemoglobin decrease during acute stroke treatment with infarct growth and clinical outcome.

PLoS One 2018 26;13(9):e0203535. Epub 2018 Sep 26.

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Background And Purpose: Anemia is associated with worse outcome in stroke, but the impact of anemia with intravenous thrombolysis or endovascular therapy has hardly been delineated. The aim of this study was to analyze the role of anemia on infarct evolution and outcome after acute stroke treatment.

Methods: 1158 patients from Bern and 321 from Los Angeles were included. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203535PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157859PMC
February 2019
2 Reads
3.234 Impact Factor

Mutations in the ENG, ACVRL1, and SMAD4 genes and clinical manifestations of hereditary haemorrhagic telangiectasia: experience from the Center for Osler's Disease, Uppsala University Hospital.

Ups J Med Sci 2018 Sep 25;123(3):153-157. Epub 2018 Sep 25.

a Department of Haematology , Uppsala University Hospital , Uppsala , Sweden.

Aim: The aim of this retrospective single-centre study was to evaluate whether mutations in the ENG, ACVRL1, and SMAD4 genes were associated with different phenotypes in hereditary haemorrhagic telangiectasia (HHT).

Methods: The case records of 21 HHT patients with verified mutations in ENG, ACVRL1, or SMAD4 genes were reviewed. The numbers of HHT diagnostic criteria fulfilled for the three genotypes were compared, as was the prevalence of complications such as iron deficiency anaemia, gastrointestinal haemorrhage, stroke, and cerebral abscess. Read More

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http://dx.doi.org/10.1080/03009734.2018.1483452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198721PMC
September 2018
1 Read

"Rebound" hypercoagulability after interruption of anticoagulation in patients with atrial fibrillation.

Int J Cardiol 2018 11;271:119

Department of Geriatrics, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, No. 17, Lu Jiang Road, Hefei 230061, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.04.123DOI Listing
November 2018
29 Reads

Immune-Thrombotic Thrombocytopenic Purpura is a Rare Cause of Ischemic Stroke in Young Adults: Case Reports and Literature Review.

J Stroke Cerebrovasc Dis 2018 Nov 12;27(11):3163-3171. Epub 2018 Sep 12.

Department of Neurology, CHU de Bordeaux, Bordeaux, France / Except Yahsou Delmas: Department of Nephrology, CHU de Bordeaux, Bordeaux, France.

Introduction: Immune thrombotic thrombocytopenic purpura (i-TTP), related to acquired ADAMTS-13 dysfunction, can lead to various neurological symptoms including ischemic stroke. To date the clinical, radiological, and biological characteristics of patients having a stroke as the inaugural manifestation of i-TTP are largely unknown.

Methods: Probable immune-TTP was defined by a low ADAMTS-13 activity associated with the presence of ADAMTS-13 inhibitors and/or favorable clinicobiological response under immunological treatments. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.07.017DOI Listing
November 2018
3 Reads

Utilizing Whole-Exome Sequencing to Characterize the Phenotypic Variability of Sickle Cell Disease.

Genet Test Mol Biomarkers 2018 Sep 5;22(9):561-567. Epub 2018 Sep 5.

4 Department of Pediatrics, King Abdullah Specialist Children's Hospital , King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia .

Background: Sickle cell disease (SCD) is a monogenic disease that has wide variety of phenotypes with both and environmental factors contributing to its severity.

Methods: We performed whole-exome sequencing (WES) in 22 Saudi SCD patients to identify variants that could explain differences in disease phenotypes. All variants, except those that were benign and likely benign, described in the ClinVar database, were considered in our analysis. Read More

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https://www.liebertpub.com/doi/10.1089/gtmb.2018.0058
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http://dx.doi.org/10.1089/gtmb.2018.0058DOI Listing
September 2018
18 Reads

Characteristics of methotrexate-induced stroke-like neurotoxicity.

Int J Hematol 2018 Dec 4;108(6):630-636. Epub 2018 Sep 4.

Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.

Intrathecal administration of methotrexate (IT-MTX) can lead to neurotoxicity. MTX-induced neurotoxicity occasionally manifests with a stroke-like presentation that is difficult to distinguish from genuine stroke. We retrospectively reviewed records of nine patients with leukemia or lymphoma and episodes of stroke-like presentation at our institute between 2010 and 2015 for whom magnetic resonance imaging (MRI) data were available. Read More

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http://dx.doi.org/10.1007/s12185-018-2525-0DOI Listing
December 2018
12 Reads

Global Mortality From Firearms, 1990-2016.

Authors:
Mohsen Naghavi Laurie B Marczak Michael Kutz Katya Anne Shackelford Megha Arora Molly Miller-Petrie Miloud Taki Eddine Aichour Nadia Akseer Rajaa M Al-Raddadi Khurshid Alam Suliman A Alghnam Carl Abelardo T Antonio Olatunde Aremu Amit Arora Mohsen Asadi-Lari Reza Assadi Tesfay Mehari Atey Leticia Avila-Burgos Ashish Awasthi Beatriz Paulina Ayala Quintanilla Suzanne Lyn Barker-Collo Till Winfried Bärnighausen Shahrzad Bazargan-Hejazi Masoud Behzadifar Meysam Behzadifar James R Bennett Ashish Bhalla Zulfiqar A Bhutta Arebu Issa Bilal Guilherme Borges Rohan Borschmann Alexandra Brazinova Julio Cesar Campuzano Rincon Félix Carvalho Carlos A Castañeda-Orjuela Lalit Dandona Rakhi Dandona Paul I Dargan Diego De Leo Samath Dhamminda Dharmaratne Eric L Ding Huyen Phuc Do David Teye Doku Kerrie E Doyle Tim Robert Driscoll Dumessa Edessa Ziad El-Khatib Aman Yesuf Endries Alireza Esteghamati Andre Faro Farshad Farzadfar Valery L Feigin Florian Fischer Kyle J Foreman Richard Charles Franklin Nancy Fullman Neal D Futran Tsegaye Tewelde Gebrehiwot Reyna Alma Gutiérrez Nima Hafezi-Nejad Hassan Haghparast Bidgoli Gessessew Bugssa Hailu Josep Maria Haro Hamid Yimam Hassen Caitlin Hawley Delia Hendrie Martha Híjar Guoqing Hu Olayinka Stephen Ilesanmi Mihajlo Jakovljevic Spencer L James Sudha Jayaraman Jost B Jonas Amaha Kahsay Amir Kasaeian Peter Njenga Keiyoro Yousef Khader Ibrahim A Khalil Young-Ho Khang Jagdish Khubchandani Aliasghar Ahmad Kiadaliri Christian Kieling Yun Jin Kim Soewarta Kosen Kristopher J Krohn G Anil Kumar Faris Hasan Lami Van C Lansingh Heidi Jane Larson Shai Linn Raimundas Lunevicius Hassan Magdy Abd El Razek Muhammed Magdy Abd El Razek Reza Malekzadeh Deborah Carvalho Malta Amanda J Mason-Jones Richard Matzopoulos Peter T N Memiah Walter Mendoza Tuomo J Meretoja Haftay Berhane Mezgebe Ted R Miller Shafiu Mohammed Maziar Moradi-Lakeh Rintaro Mori Devina Nand Cuong Tat Nguyen Quyen Le Nguyen Dina Nur Anggraini Ningrum Felix Akpojene Ogbo Andrew T Olagunju George C Patton Michael R Phillips Suzanne Polinder Farshad Pourmalek Mostafa Qorbani Afarin Rahimi-Movaghar Vafa Rahimi-Movaghar Mahfuzar Rahman Rajesh Kumar Rai Chhabi Lal Ranabhat David Laith Rawaf Salman Rawaf Ali Rowhani-Rahbar Mahdi Safdarian Saeid Safiri Rajesh Sagar Joseph S Salama Juan Sanabria Milena M Santric Milicevic Rodrigo Sarmiento-Suárez Benn Sartorius Maheswar Satpathy David C Schwebel Soraya Seedat Sadaf G Sepanlou Masood Ali Shaikh Nigussie Tadesse Sharew Ivy Shiue Jasvinder A Singh Mekonnen Sisay Vegard Skirbekk Adauto Martins Soares Filho Dan J Stein Mark Andrew Stokes Mu'awiyyah Babale Sufiyan Mamta Swaroop Bryan L Sykes Rafael Tabarés-Seisdedos Fentaw Tadese Bach Xuan Tran Tung Thanh Tran Kingsley Nnanna Ukwaja Tommi Juhani Vasankari Vasily Vlassov Andrea Werdecker Pengpeng Ye Paul Yip Naohiro Yonemoto Mustafa Z Younis Zoubida Zaidi Maysaa El Sayed Zaki Simon I Hay Stephen S Lim Alan D Lopez Ali H Mokdad Theo Vos Christopher J L Murray

JAMA 2018 08;320(8):792-814

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

Importance: Understanding global variation in firearm mortality rates could guide prevention policies and interventions.

Objective: To estimate mortality due to firearm injury deaths from 1990 to 2016 in 195 countries and territories.

Design, Setting, And Participants: This study used deidentified aggregated data including 13 812 location-years of vital registration data to generate estimates of levels and rates of death by age-sex-year-location. Read More

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http://dx.doi.org/10.1001/jama.2018.10060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143020PMC
August 2018
26 Reads
35.290 Impact Factor

Statin-induced myopathy prevented by creatine administration.

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Clinica Neurologica, Università degli Studi di Genova, Dipartimento di Neuroscienze Riabilitazione Oftalmologia Genetica e Scienze Materno-Infantili (DINOGMI), Genova, Italy.

A 66-year-old woman with chronic myeloid leukaemia in nilotinib-induced remission was diagnosed with amaurosis fugax, caused by carotid stenosis. Serum cholesterol was 316 mg/dL (Low-Density Lipoprotein (LDL) cholesterol 213 mg/dL). Nilotinib was discontinued and replaced by interferon. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22539
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http://dx.doi.org/10.1136/bcr-2018-225395DOI Listing
August 2018
16 Reads

Cerebral Venous Malformations in a Chinese Population: Clinical Manifestations, Radiological Characteristics, and Long-Term Prognosis.

World Neurosurg 2018 Dec 25;120:e472-e479. Epub 2018 Aug 25.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.

Objective: We elucidated the clinical and radiological characteristics and analyzed the risk factors for hemorrhage and poor outcomes of cerebral venous malformations (CVMs) in a northern Chinese population.

Methods: We included 60 consecutive patients with CVM patients in Beijing Tiantan Hospital from January 2011 to February 2018. The clinical manifestations, radiological characteristics, management, and outcomes were elucidated and analyzed. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.106DOI Listing
December 2018
10 Reads

Pro-gastrin-releasing peptide and outcome in patients with heart failure and anaemia: results from the RED-HF study.

ESC Heart Fail 2018 12 25;5(6):1052-1059. Epub 2018 Aug 25.

Department of Medical Biochemistry, Oslo University Hospital Radiumhospitalet, Oslo, Norway.

Aims: Neuroendocrine activation is associated with poor outcome in heart failure (HF). The neuropeptide gastrin-releasing peptide (GRP), derived from the precursor proGRP1-125 (proGRP), has recently been implicated in inflammation and wound repair. We investigated the predictive value of proGRP on clinical outcomes in HF patients with reduced ejection fraction. Read More

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http://dx.doi.org/10.1002/ehf2.12312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300802PMC
December 2018
8 Reads