4,741 results match your criteria Blood Dyscrasias and Stroke


Use of Measures of Inflammation and Kidney Function for Prediction of Atherosclerotic Vascular Disease Events and Death in Patients With CKD: Findings From the CRIC Study.

Am J Kidney Dis 2018 Dec 10. Epub 2018 Dec 10.

Division of Kidney Diseases and Hypertension, George Washington University, Washington, DC. Electronic address:

Rationale & Objective: Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney disease (CKD). We sought to determine whether the addition of measures of inflammation and kidney function to traditional estimation tools improves prediction of these events in a diverse cohort of patients with CKD.

Study Design: Observational cohort study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.09.012DOI Listing
December 2018
1 Read

Prevalence of comorbidities in systemic sclerosis versus rheumatoid arthritis: a comparative, multicenter, matched-cohort study.

Arthritis Res Ther 2018 Dec 4;20(1):267. Epub 2018 Dec 4.

Joint Rheumatology Program, 1st Department of Propedeutic Internal Medicine-Rheumatology Unit, National and Kapodistrian University of Athens, School of Medicine, Laikon General Hospital, Athens, Greece.

Background: Comorbidities are common in chronic systemic connective tissue diseases and are associated with adverse outcomes, increased morbidity and mortality. Although the prevalence of comorbidities has been well-studied in isolated diseases, comparative studies between different autoimmune diseases are limited. In this study, we compared the prevalence of common comorbidities between patients with systemic sclerosis (SSc) and patients with rheumatoid arthritis (RA). Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1771-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280404PMC
December 2018
3 Reads

Hemichorea associated with cavernous angioma and a small errhysis: A case report and literature review.

Medicine (Baltimore) 2018 Oct;97(43):e12889

Departments of Neurosurgery.

Rationale: Chorea is a movement disorder characterized by randomly appearing involuntary movements of the face, neck, limbs, or trunk. Hemichorea is unilateral, involving one side of the body. Hemichorea is commonly caused by non-ketotic hyperglycemia and/or cerebrovascular injury to the contralateral basal ganglia. Read More

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http://dx.doi.org/10.1097/MD.0000000000012889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221695PMC
October 2018
1 Read

Indwelling ports for prophylactic RBC exchanges in sickle cell patients: Comparison of bard and vortex ports.

J Clin Apher 2018 Dec 2;33(6):666-670. Epub 2018 Nov 2.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Introduction: Red blood cell exchange (RCE) procedures are commonly used for stroke prevention in sickle cell disease (SCD) patients. We compared two different dual lumen ports used for RCE because differences between the port and catheter design may lead to functional variance.

Methods: We reviewed the RCE parameters of SCD patients following implantable port placement encountered at a single institution. Read More

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http://dx.doi.org/10.1002/jca.21663DOI Listing
December 2018

Recurrent thrombosis after carotid endarterectomy secondary to activated protein C resistance and essential thrombocytosis: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e13118

Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, Ulsan University, Republic of Korea.

Rationale: Thrombosis is a major cause of morbidity in the perioperative period. Although many risk factors are known, activated protein C resistance is a prominent risk for thrombosis. Activated protein C resistance frequently occurs with recurrent thromboembolism. Read More

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http://dx.doi.org/10.1097/MD.0000000000013118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221756PMC
November 2018
2 Reads

Safety of Therapeutic Plasma Exchange for the Treatment of Guillain-Barré Syndrome in Polycythemia Vera.

Neurologist 2018 Nov;23(6):185-187

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York.

Polycythemia vera (PV) is a risk factor for systemic thromboses and ischemic stroke. This has been attributed to blood hyperviscosity, the result of increased blood cell production. Intravenous immunoglobulin, which is indicated for the treatment of numerous hematologic and neurological conditions also causes increased serum viscosity and has been associated with ischemic strokes in the setting of PV. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000197DOI Listing
November 2018
3 Reads

Triple therapy: worth the risk?

Minerva Med 2018 Oct;109(5):403-405

Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany -

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https://www.minervamedica.it/index2.php?show=R10Y2018N05A040
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http://dx.doi.org/10.23736/S0026-4806.18.05564-7DOI Listing
October 2018
5 Reads

Increased Risk of Ischemic Stroke in Multiple Myeloma Associated With Lenalidomide Treatment: A Case Report and Review of the Literature.

Clin Neuropharmacol 2018 Nov/Dec;41(6):232-235

Department of Neurology and Stroke Center, La Paz University Hospital, Autonomous University of Madrid, La Paz University Hospital Health Research Institute (IdiPAZ), Madrid, Spain.

Objective: The aim of the study was to illustrate the increased risk of ischemic stroke in the context of multiple myeloma (MM) under treatment with lenalidomide combined with dexamethasone.

Methods: This is a case report and literature review.

Results: A 62-year-old woman diagnosed with relapsed MM under treatment with lenalidomide and dexamethasone presented with acute onset disorientation, disturbed behavior, and aphasia. Read More

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http://dx.doi.org/10.1097/WNF.0000000000000310DOI Listing
December 2018
12 Reads

Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders.

Eur J Hum Genet 2018 Sep 25. Epub 2018 Sep 25.

Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92093, USA.

The Central Asian Kyrgyz highland population provides a unique opportunity to address genetic diversity and understand the genetic mechanisms underlying high-altitude pulmonary hypertension (HAPH). Although a significant fraction of the population is unaffected, there are susceptible individuals who display HAPH in the absence of any lung, cardiac or hematologic disease. We report herein the analysis of the whole-genome sequencing of healthy individuals compared with HAPH patients and other controls (total n = 33). Read More

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http://www.nature.com/articles/s41431-018-0270-8
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http://dx.doi.org/10.1038/s41431-018-0270-8DOI Listing
September 2018
4 Reads
4.350 Impact Factor

"Rebound" hypercoagulability after interruption of anticoagulation in patients with atrial fibrillation.

Int J Cardiol 2018 11;271:119

Department of Geriatrics, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, No. 17, Lu Jiang Road, Hefei 230061, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.04.123DOI Listing
November 2018
9 Reads

Immune-Thrombotic Thrombocytopenic Purpura is a Rare Cause of Ischemic Stroke in Young Adults: Case Reports and Literature Review.

J Stroke Cerebrovasc Dis 2018 Nov 12;27(11):3163-3171. Epub 2018 Sep 12.

Department of Neurology, CHU de Bordeaux, Bordeaux, France / Except Yahsou Delmas: Department of Nephrology, CHU de Bordeaux, Bordeaux, France.

Introduction: Immune thrombotic thrombocytopenic purpura (i-TTP), related to acquired ADAMTS-13 dysfunction, can lead to various neurological symptoms including ischemic stroke. To date the clinical, radiological, and biological characteristics of patients having a stroke as the inaugural manifestation of i-TTP are largely unknown.

Methods: Probable immune-TTP was defined by a low ADAMTS-13 activity associated with the presence of ADAMTS-13 inhibitors and/or favorable clinicobiological response under immunological treatments. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.07.017DOI Listing
November 2018
1 Read

Characteristics of methotrexate-induced stroke-like neurotoxicity.

Int J Hematol 2018 Dec 4;108(6):630-636. Epub 2018 Sep 4.

Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.

Intrathecal administration of methotrexate (IT-MTX) can lead to neurotoxicity. MTX-induced neurotoxicity occasionally manifests with a stroke-like presentation that is difficult to distinguish from genuine stroke. We retrospectively reviewed records of nine patients with leukemia or lymphoma and episodes of stroke-like presentation at our institute between 2010 and 2015 for whom magnetic resonance imaging (MRI) data were available. Read More

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http://dx.doi.org/10.1007/s12185-018-2525-0DOI Listing
December 2018
5 Reads

Global Mortality From Firearms, 1990-2016.

Authors:
Mohsen Naghavi Laurie B Marczak Michael Kutz Katya Anne Shackelford Megha Arora Molly Miller-Petrie Miloud Taki Eddine Aichour Nadia Akseer Rajaa M Al-Raddadi Khurshid Alam Suliman A Alghnam Carl Abelardo T Antonio Olatunde Aremu Amit Arora Mohsen Asadi-Lari Reza Assadi Tesfay Mehari Atey Leticia Avila-Burgos Ashish Awasthi Beatriz Paulina Ayala Quintanilla Suzanne Lyn Barker-Collo Till Winfried Bärnighausen Shahrzad Bazargan-Hejazi Masoud Behzadifar Meysam Behzadifar James R Bennett Ashish Bhalla Zulfiqar A Bhutta Arebu Issa Bilal Guilherme Borges Rohan Borschmann Alexandra Brazinova Julio Cesar Campuzano Rincon Félix Carvalho Carlos A Castañeda-Orjuela Lalit Dandona Rakhi Dandona Paul I Dargan Diego De Leo Samath Dhamminda Dharmaratne Eric L Ding Huyen Phuc Do David Teye Doku Kerrie E Doyle Tim Robert Driscoll Dumessa Edessa Ziad El-Khatib Aman Yesuf Endries Alireza Esteghamati Andre Faro Farshad Farzadfar Valery L Feigin Florian Fischer Kyle J Foreman Richard Charles Franklin Nancy Fullman Neal D Futran Tsegaye Tewelde Gebrehiwot Reyna Alma Gutiérrez Nima Hafezi-Nejad Hassan Haghparast Bidgoli Gessessew Bugssa Hailu Josep Maria Haro Hamid Yimam Hassen Caitlin Hawley Delia Hendrie Martha Híjar Guoqing Hu Olayinka Stephen Ilesanmi Mihajlo Jakovljevic Spencer L James Sudha Jayaraman Jost B Jonas Amaha Kahsay Amir Kasaeian Peter Njenga Keiyoro Yousef Khader Ibrahim A Khalil Young-Ho Khang Jagdish Khubchandani Aliasghar Ahmad Kiadaliri Christian Kieling Yun Jin Kim Soewarta Kosen Kristopher J Krohn G Anil Kumar Faris Hasan Lami Van C Lansingh Heidi Jane Larson Shai Linn Raimundas Lunevicius Hassan Magdy Abd El Razek Muhammed Magdy Abd El Razek Reza Malekzadeh Deborah Carvalho Malta Amanda J Mason-Jones Richard Matzopoulos Peter T N Memiah Walter Mendoza Tuomo J Meretoja Haftay Berhane Mezgebe Ted R Miller Shafiu Mohammed Maziar Moradi-Lakeh Rintaro Mori Devina Nand Cuong Tat Nguyen Quyen Le Nguyen Dina Nur Anggraini Ningrum Felix Akpojene Ogbo Andrew T Olagunju George C Patton Michael R Phillips Suzanne Polinder Farshad Pourmalek Mostafa Qorbani Afarin Rahimi-Movaghar Vafa Rahimi-Movaghar Mahfuzar Rahman Rajesh Kumar Rai Chhabi Lal Ranabhat David Laith Rawaf Salman Rawaf Ali Rowhani-Rahbar Mahdi Safdarian Saeid Safiri Rajesh Sagar Joseph S Salama Juan Sanabria Milena M Santric Milicevic Rodrigo Sarmiento-Suárez Benn Sartorius Maheswar Satpathy David C Schwebel Soraya Seedat Sadaf G Sepanlou Masood Ali Shaikh Nigussie Tadesse Sharew Ivy Shiue Jasvinder A Singh Mekonnen Sisay Vegard Skirbekk Adauto Martins Soares Filho Dan J Stein Mark Andrew Stokes Mu'awiyyah Babale Sufiyan Mamta Swaroop Bryan L Sykes Rafael Tabarés-Seisdedos Fentaw Tadese Bach Xuan Tran Tung Thanh Tran Kingsley Nnanna Ukwaja Tommi Juhani Vasankari Vasily Vlassov Andrea Werdecker Pengpeng Ye Paul Yip Naohiro Yonemoto Mustafa Z Younis Zoubida Zaidi Maysaa El Sayed Zaki Simon I Hay Stephen S Lim Alan D Lopez Ali H Mokdad Theo Vos Christopher J L Murray

JAMA 2018 08;320(8):792-814

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

Importance: Understanding global variation in firearm mortality rates could guide prevention policies and interventions.

Objective: To estimate mortality due to firearm injury deaths from 1990 to 2016 in 195 countries and territories.

Design, Setting, And Participants: This study used deidentified aggregated data including 13 812 location-years of vital registration data to generate estimates of levels and rates of death by age-sex-year-location. Read More

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http://dx.doi.org/10.1001/jama.2018.10060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143020PMC
August 2018
15 Reads
35.290 Impact Factor

Statin-induced myopathy prevented by creatine administration.

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Clinica Neurologica, Università degli Studi di Genova, Dipartimento di Neuroscienze Riabilitazione Oftalmologia Genetica e Scienze Materno-Infantili (DINOGMI), Genova, Italy.

A 66-year-old woman with chronic myeloid leukaemia in nilotinib-induced remission was diagnosed with amaurosis fugax, caused by carotid stenosis. Serum cholesterol was 316 mg/dL (Low-Density Lipoprotein (LDL) cholesterol 213 mg/dL). Nilotinib was discontinued and replaced by interferon. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22539
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http://dx.doi.org/10.1136/bcr-2018-225395DOI Listing
August 2018
6 Reads

An Audit of Thrombophilia Testing in Patients with Ischemic Stroke or Transient Ischemic Attack: The Futility of Testing.

J Stroke Cerebrovasc Dis 2018 Nov 22;27(11):3301-3305. Epub 2018 Aug 22.

Department of Pathology, Division of Transfusion Medicine and Hemostasis, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Objectives: Many patients admitted with an ischemic stroke or transient ischemic attack (TIA) undergo thrombophilia testing. There is limited evidence to support this practice. We examined the effect of thrombophilia testing on management of patients admitted with an ischemic stroke or TIA. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.07.032DOI Listing
November 2018
12 Reads

Fetal vascular malperfusion, an update.

APMIS 2018 Jul;126(7):561-569

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Fetal vascular malperfusion is the most recent term applied to a group of placental lesions indicating reduced or absent perfusion of the villous parenchyma by the fetus. The most common etiology of malperfusion is umbilical cord obstruction leading to stasis, ischemia, and in some cases thrombosis. Other contributing factors may include maternal diabetes, fetal cardiac insufficiency or hyperviscosity, and inherited or acquired thrombophilias. Read More

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http://dx.doi.org/10.1111/apm.12849DOI Listing
July 2018
3 Reads

Manifestation of anaplasmosis as cerebral infarction: a case report.

BMC Infect Dis 2018 Aug 17;18(1):409. Epub 2018 Aug 17.

Departments of Internal Medicine, College of Medicine, Chosun University, 588 Seosuk-dong, Dong-gu, Gwangju, 61453, Republic of Korea.

Background: Human granulocytic anaplasmosis is a tick-borne zoonotic disease caused by Anaplasma phagocytophilum, an obligate intracellular granulocytotropic bacterium.

Case Presentation: A 70-year-old female patient was admitted with the clinical signs of fever and an altered state of consciousness 1 week after experiencing a tick bite while planting lawn grass. Magnetic resonance imaging, performed at the time of admission, indicated cerebral infarction in the left basal ganglia, whereas increasing immunofluorescence assay antibody titers for A. Read More

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http://dx.doi.org/10.1186/s12879-018-3321-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098650PMC
August 2018
1 Read

Possible clinical marker of first attack of HaNDL syndrome (stroke-like mimics) in emergency room: a case report.

Neurol Sci 2018 Nov 4;39(11):2003-2005. Epub 2018 Aug 4.

Headache Centre, Neurosciences Department, Niguarda Ca' Granda Hospital, Milan, Italy.

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http://link.springer.com/10.1007/s10072-018-3517-9
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http://dx.doi.org/10.1007/s10072-018-3517-9DOI Listing
November 2018
1 Read

The Genetic Landscape of Cerebral Steno-Occlusive Arteriopathy and Stroke in Sickle Cell Anemia.

J Stroke Cerebrovasc Dis 2018 Nov 31;27(11):2897-2904. Epub 2018 Jul 31.

Departments of Neurology, University of Washington, Seattle, Washington; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.

Sickle cell disease (SCD) is one of the most common autosomal recessive diseases in humans, occurring at a frequency of 1 in 365 African-American and 1 in 50 sub-Saharan African births. Despite progress in managing complications of SCD, these remain a major health burden worldwide. Stroke is a common and serious complication of SCD, most often associated with steno-occlusive cerebral arteriopathy, but little is known about its pathogenesis. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.06.004DOI Listing
November 2018
3 Reads

Cardiovascular oncology: exploring the effects of targeted cancer therapies on atherosclerosis.

Curr Opin Lipidol 2018 Oct;29(5):381-388

Department of Medical Biochemistry, Subdivision Experimental Vascular Biology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.

Purpose Of Review: Targeted cancer therapies have revolutionized the treatment of cancer in the past decade, but cardiovascular toxicity is a rising problem in cancer patients. Here we discuss the effects of targeted cancer therapies on atherosclerosis. Increasing the awareness of these adverse effects will promote the development of evidence-based preventive strategies in the emerging field of cardiovascular oncology. Read More

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http://dx.doi.org/10.1097/MOL.0000000000000538DOI Listing
October 2018

Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler Study.

J Stroke Cerebrovasc Dis 2018 Oct 24;27(10):2703-2706. Epub 2018 Jul 24.

Disciplina de Neurologia Clínica, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil; Programa Integrado de Neurologia, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil.

Background: Impairment of vasodilatory capacity reflecting reduced cerebrovascular reserve was previously shown in adults with sickle cell disease (SCD) and might play a role in the pathophysiology of stroke in such patients. We examined the hypothesis that children with SCD would also have a higher frequency of impaired cerebral vasoreactivity when compared with healthy age- and gender-matched controls.

Methods: Patients were recruited from our hematology outpatient clinic. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.05.042DOI Listing
October 2018

Balance control is impaired in adults with sickle cell anaemia.

Somatosens Mot Res 2018 06 16;35(2):109-118. Epub 2018 Jul 16.

a Rehabilitation Sciences Master's Programme , Augusto Motta University Center , Rio de Janeiro , Brazil.

Background: Musculoskeletal involvement and cerebrovascular disease are common in sickle cell anaemia (SCA). These changes are potentially important factors that modify the control of balance in this population.

Objective: To assess balance control in adults with SCA and investigate the associations among balance, posture and muscle function. Read More

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http://dx.doi.org/10.1080/08990220.2018.1481829DOI Listing
June 2018
10 Reads
0.580 Impact Factor

Giant cavernous malformations: A single center experience and literature review.

J Clin Neurosci 2018 Oct 6;56:108-113. Epub 2018 Jul 6.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, NO. 6 Tiantan Xili, Dongcheng District, Beijing 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing, PR China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, PR China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, PR China. Electronic address:

Intracranial giant cavernous malformations (GCMs) are rarely reported because of their extremely low incidence. Knowledge of GCM is poor. The goals of this study were to analyze the epidemiological characteristics, clinical manifestations, radiological findings, microsurgical treatment, and neurological outcomes of GCMs. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.06.042DOI Listing
October 2018
1 Read
1.320 Impact Factor

Deficiency of Adenosine Deaminase 2 in Adult Siblings: Many Years of a Misdiagnosed Disease With Severe Consequences.

Front Immunol 2018 14;9:1361. Epub 2018 Jun 14.

National Human Genome Research Institute, National Institute of Health, Bethesda, MD, United States.

Objective: Describe the clinical characteristics and histopathology findings in a family with two siblings affected with deficiency of adenosine deaminase 2 (DADA2). Both patients presented in childhood with polyarthritis and developed significant neurological and gastrointestinal features of DADA2 in ear, including variable degrees of immunologic and hematologic manifestations.

Methods: Adenosine Deaminase 2 (ADA2; also known as exon sequencing and serum ADA2 levels were performed to confirm the diagnosis of DADA2. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010516PMC
June 2018
2 Reads

Nonaneurysmal Subarachnoid Hemorrhage in Sickle Cell Disease: Description of a Case and a Review of the Literature.

Neurologist 2018 Jul;23(4):122-127

Department of Pediatrics, Division of Child Neurology, Children's Hospital of Pittsburgh of UPMC.

Descriptions of the natural history of cerebrovascular complications of sickle cell disease (SCD) characterize ischemic stroke as common during childhood and hemorrhagic stroke as more common in adulthood. Childhood ischemic stroke is attributed to vasculopathy with moyamoya syndrome. Hemorrhagic stroke is commonly attributed to aneurysms accompanying HbSS cerebral vasculopathy in SCD. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000181DOI Listing
July 2018
17 Reads

Features of vascular adverse events in Japanese patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a retrospective study of the CML Cooperative Study Group database.

Ann Hematol 2018 Nov 26;97(11):2081-2088. Epub 2018 Jun 26.

Department of Hematology and Infectious Diseases, Kumamoto University Hospital, Kumamoto, Japan.

This study investigated the incidence rate and features of vascular adverse events (VAEs) in Japanese patients with chronic myeloid leukemia (CML) who were treated with tyrosine kinase inhibitors (TKIs). The analysis included 369 CML patients in the chronic or accelerated phases, selected from the CML Cooperative Study Group database; 25 events in 23 (6.2%) of these patients were VAEs. Read More

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http://dx.doi.org/10.1007/s00277-018-3412-8DOI Listing
November 2018
12 Reads

Complications of Durable Left Ventricular Assist Device Therapy.

Authors:
Sitaramesh Emani

Crit Care Clin 2018 Jul;34(3):465-477

Advanced Heart Failure and Cardiac Transplant, Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, 473 West 12th Avenue, Suite 200 DHLRI, Columbus, OH 43221, USA. Electronic address:

Heart failure patients on durable left ventricular assist device support experience improved survival, quality of life, and exercise capacity. The complication rate, however, remains unacceptably high, although it has declined with improvements in pump design, better patient selection, and greater understanding of the pump physiology and flow dynamics. Most complications are categorized as those related to the pump-patient interface or those related to patient physiology. Read More

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http://dx.doi.org/10.1016/j.ccc.2018.03.003DOI Listing
July 2018
1 Read

Fat Emboli Syndrome.

Del Med J 2017 May;89(5):148-150

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May 2017
3 Reads

Association Between Sickle Cell Trait With Selected Chronic Medical Conditions in U.S. Service Members.

Mil Med 2018 Nov;183(11-12):e735-e740

Department of Preventive Medicine and Biostatistics, Uniformed Services of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD.

Introduction: Sickle cell trait (SCT), the heterozygous carrier state for hemoglobin S, is present in an estimated 1.6% of all newborns and 7.3% in black individuals in the USA. Read More

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http://dx.doi.org/10.1093/milmed/usy125DOI Listing
November 2018
4 Reads

Abnormal fibrinogen with an Aα 16Arg → Cys substitution is associated with multiple cerebral infarctions.

J Thromb Thrombolysis 2018 Oct;46(3):409-419

Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.

We found a heterozygous dysfibrinogenemia caused by a substitution of AαArg16Cys. The proband suffered multiple cerebral infarctions. Routine coagulation tests revealed a prolonged thrombin time. Read More

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http://dx.doi.org/10.1007/s11239-018-1689-zDOI Listing
October 2018
10 Reads

Ischemic Stroke Caused by Secondary Polycythemia and Incidentally-Found Renal Cell Carcinoma: A Case Report.

Am J Case Rep 2018 Jun 4;19:638-641. Epub 2018 Jun 4.

Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.

BACKGROUND Secondary polycythemia is a potential complication of an erythropoietin-secreting renal cell carcinoma. Increased red blood cell mass can elevate blood viscosity, which can impair blood flow, making individuals susceptible to vaso-occlusive events. One of the serious potential complications of a hyper-viscous state is ischemic stroke. Read More

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http://dx.doi.org/10.12659/AJCR.909322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016561PMC
June 2018
2 Reads

A Case of Posterior Circulation Ischemic Stroke Caused by Heparin-Induced Thrombocytopenia after Detaining Hepatic Arterial Infusion Catheter.

J Stroke Cerebrovasc Dis 2018 Sep 30;27(9):e196-e200. Epub 2018 May 30.

Department of Neurological Surgery, Kagawa Rosai Hospital, Kagawa, Japan.

In Japan, hepatic arterial infusion chemotherapy (HAIC) using reservoir system is recommended for patients with hepatocellular carcinoma (HCC) whose hepatic spare ability is favorable. Arterial infusion catheter is commonly detained in hepatic artery via femoral or brachial artery. In our hospital, catheter is often inserted by puncturing the left subclavian or brachial artery considering the patient's activities of daily living (ADL) during long-term detaining. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.04.011DOI Listing
September 2018
2 Reads

Lesson of the month 1: To stop a fit, but swinging low.

Clin Med (Lond) 2018 Jun;18(3):256-258

Rutgers / Saint Peter's University Hospital, New Jersey, USA.

This is a case of an elderly woman who presented to our emergency room with an episode of a witnessed fall. The past medical history of the patient was significant for post-stroke epilepsy for which she was on oxcarbazepine. Initial blood work showed a white cell count of 4. Read More

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http://dx.doi.org/10.7861/clinmedicine.18-3-256DOI Listing
June 2018
11 Reads

Intraventricular haemorrhage and obstructive hydrocephalus in a term neonate: an uncommon presentation of haemophilia B.

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1136/bcr-2018-225341DOI Listing
May 2018
9 Reads

CD59 deficiency presenting as polyneuropathy and Moyamoya syndrome with endothelial abnormalities of small brain vessels.

Eur J Paediatr Neurol 2018 Sep 13;22(5):870-877. Epub 2018 Apr 13.

Center for Pediatrics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Pediatrics, Department of Neuropediatrics and Muscle Disorders, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

CD59 is involved in lymphocyte signal transduction and regulates complement-mediated cell lysis by inhibiting the membrane attack complex. In the cases reported so far, congenital isolated CD59 deficiency was associated with recurrent episodes of hemolytic anemia, peripheral neuropathy, and strokes. Here, we report on a patient from a consanguineous Turkish family, who had a first episode of hemolytic anemia at one month of age and presented at 14 months with acute Guillain-Barré syndrome (GBS). Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.04.003DOI Listing
September 2018
12 Reads

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome.

N Engl J Med 2018 May;378(21):1965-1975

From Sorbonne Université INSERM Unité Mixte de Recherche (UMRS) 1166, Institute of Cardiometabolism and Nutrition (A.C., G.L.), Service de Médecine Intensive-Réanimation, Institut de Cardiologie, Assistance Publique-Hôpitaux de Paris (APHP) Hôpital Pitié-Salpêtrière (A.C.), Département de Biostatistiques, Santé Publique et Information Médicale, Centre de Pharmacoépidémiologie, APHP Hôpital Pitié-Salpêtrière (D.H.), Sorbonne Université, Unité de Recherche Clinique Pitié-Salpêtrière (D.H.), Sorbonne Université INSERM UMRS 1158 (A.D.), Service de Médecine Intensive-Réanimation et Pneumologie, APHP Hôpital Pitié-Salpêtrière (A.D.), Service de Médecine Intensive et Réanimation, Centre Hospitalier Universitaire (CHU) Saint Louis (L.Z.), Service de Médecine Intensive et Réanimation, CHU Saint Antoine (E.M.), Service de Médecine Intensive et Réanimation, APHP Bichat Hospital, Diderot University (L. Bouadma), and Service de Chirurgie Thoracique et Cardiovasculaire, APHP Hôpital Pitié-Salpêtrière, Institut de Cardiologie (G.L.), Paris, Service de Médecine Intensive et Réanimation, Besançon University Hospital, and Research Unit Equipe Avenir 3920 and Structure Fédérative de Recherche 4234, University of Franche Comté, Besançon (G.C.), Service de Médecine Intensive et Réanimation, CHU Pontchaillou, Rennes (S.L.), Service de Médecine Intensive et Réanimation, CHU Hôpital Nord, APHM, Marseille (C.G.), Service de Médecine Intensive et Réanimation, CHU Saint Denis, Saint Denis (D.D.S.), Service de Médecine Intensive et Réanimation, CHU Le Mans, Le Mans (P.T.), Département d'Anesthésie et Réanimation, CHU de Rouen (B.V.), Service de Médecine Intensive et Réanimation, Rouen University Hospital (G.B.), and Normandie University, Université de Rouen, Equipe Avenir 3830, Rouen University Hospital (G.B.), Rouen, Service de Médecine Intensive et Réanimation, CHU Nancy and INSERM Unité 1116, Université de Lorraine, Nancy (B.L.), Service de Médecine Intensive et Réanimation, CHU Avicenne, Bobigny (Y.C.), Service de Médecine Intensive et Réanimation, CHU Kremlin Bicêtre, Le Kremlin Bicêtre (C.R.), Service de Réanimation Polyvalente, Hôpital de Chartres, Chartres (P.K.), CHU Martinique, Fort-de-France (H.M.), and Service de Médecine Intensive et Réanimation, Centre Hospitalier Universitaire d'Angers, Université d'Angers, Angers (A.M.) - all in France; the Interdepartmental Division of Critical Care Medicine, Departments of Medicine and Physiology, Institute for Health Management, Policy, and Evaluation, University of Toronto (L. Brochard, N.D.F., E.F.), Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital (L. Brochard, A.S.S.), and the Department of Medicine, Division of Respirology, University Health Network and Sinai Health System, Toronto General Hospital (N.D.F., E.F.), Toronto; and the Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, and New York-Presbyterian Hospital, Columbia University, New York (D.B.).

Background: The efficacy of venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) remains controversial.

Methods: In an international clinical trial, we randomly assigned patients with very severe ARDS, as indicated by one of three criteria - a ratio of partial pressure of arterial oxygen (Pao) to the fraction of inspired oxygen (Fio) of less than 50 mm Hg for more than 3 hours; a Pao:Fio of less than 80 mm Hg for more than 6 hours; or an arterial blood pH of less than 7.25 with a partial pressure of arterial carbon dioxide of at least 60 mm Hg for more than 6 hours - to receive immediate venovenous ECMO (ECMO group) or continued conventional treatment (control group). Read More

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http://dx.doi.org/10.1056/NEJMoa1800385DOI Listing
May 2018
33 Reads

Five-Year Risk of Stroke after TIA or Minor Ischemic Stroke.

N Engl J Med 2018 Jun 16;378(23):2182-2190. Epub 2018 May 16.

From Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Neurology and Stroke Center (P.A., P.C.L., L.M.T., J.L., P.-J.T.), and the Department of Cardiology (P.G.S.), Bichat Hospital, INSERM Laboratory for Vascular Translational Science-Unité 1148, Département Hospitalo-Universitaire Fibrose Inflammation Remodelage, Université Paris-Diderot, Sorbonne-Paris Cité, and AP-HP, Department of Biostatistics, Université Paris-Diderot, Sorbonne-Paris Cité, Fernand Widal Hospital (É.V.), Paris, and Université Lille, Centre Hospitalier Universitaire Lille, Équipe d'Accueil 2694-Santé Publique: Épidémiologie et Qualité des Soins, Lille (J.L.) - all in France; the Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, CA (G.W.A.); the Department of Neurology, Hôtel-Dieu de France, Saint Joseph University, Beirut, Lebanon (H. Abboud); the Stroke Unit, San Camillo Hospital, Rome (S.A.); Ärztliche Leitung der Klinik für Neurologie, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin (H. Audebert), Klinik für Neurologie, Allgemeines Krankenhaus Celle, Celle (W.H.), and the Department of Neurology, Universitäts Medizin Mannheim, Heidelberg University, Heidelberg (M.G.H.) - all in Germany; Shaare Zedek Medical Center, Jerusalem, Israel (N.M.B.); the Cerebrovascular Disease Service, Beth Israel Deaconess Medical Center, Harvard University, Boston (L.R.C.); Serviço de Neurologia, Hospital de Santo António-Centro Hospitalar do Porto, Porto (M.C.), and the Department of Neurosciences, Service of Neurology, Hospital Santa Maria, University of Lisbon, Lisbon (J.M.F.) - both in Portugal; the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia (G.A.D.); the Stroke Unit and Neurology Service, University Hospital José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico (F.G.-R.); the Neurovascular Research Unit and Health Research Board, Stroke Clinical Trials Network Ireland, University College Dublin, Dublin (P.J.K.); the Comprehensive Stroke Center, Palacký University and University Hospital Olomouc (M.K.), and the Department of Nursing, Faculty of Health Science, Palacký University (D.Š), Olomouc, Czech Republic; the Department of Neurology, Kaohsiung Medical University Chung-Ho Memorial Hospital and Kaohsiung Medical University, Kaohsiung, Taiwan (H.-F.L.); the Stroke Unit, Department of Neurology, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona (C.M.), the Stroke Unit, Hospital Universitari Arnau de Vilanova, Universitat de Lleida, Lleida (F.P.), and the Stroke Unit, Department of Neurology, Albacete University Hospital, Universidad de Castilla-La Mancha, Albacete (T.S.) - all in Spain; the Department of Neurology, Nowon Eulji Medical Center, Eulji University, Seoul, South Korea (J.M.P.); the Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford (P.M.R.), and the National Heart and Lung Institute Imperial College, Institute of Cardiovascular Medicine and Science Royal Brompton Hospital, London (P.G.S.) - both in the United Kingdom; the International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo (S.U.); the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing (Y.W.); and the Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong (L.K.S.W.).

Background: After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke and other vascular events is not well known. In this follow-up to a report on 1-year outcomes from a registry of TIA clinics in 21 countries that enrolled 4789 patients with a TIA or minor ischemic stroke from 2009 through 2011, we examined the 5-year risk of stroke and vascular events.

Methods: We evaluated patients who had had a TIA or minor stroke within 7 days before enrollment in the registry. Read More

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http://dx.doi.org/10.1056/NEJMoa1802712DOI Listing
June 2018
14 Reads
2 Citations
55.870 Impact Factor

Palatal tremor as a manifestation of posterior circulation haemorrhagic stroke.

BMJ Case Rep 2018 May 14;2018. Epub 2018 May 14.

Department of Medicine, John H Stroger Jr Hospital of Cook County, Chicago, Illinois, USA.

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http://dx.doi.org/10.1136/bcr-2018-224518DOI Listing
May 2018
1 Read

Cardiovascular diseases in congenital prekallikrein deficiency: comparison with other chance-associated morbidities.

Blood Coagul Fibrinolysis 2018 Jul;29(5):423-428

Division of Medicine, Padua City Hospital, Padua, Italy.

: To compare the prevalence of cardiovascular diseases with other chance-associated morbidities in patients with congenital prekallikrein deficiency. Patients with prekallikrein deficiency were gathered from two time unlimited PubMed searches and from personal files. Inclusion criteria were prekallikrein level less than 15% of normal; correction of aPTT on long incubation times; prolonged aPTT corrected by normal plasma or serum; normal prothrombin time and normal FXII and FXI. Read More

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http://dx.doi.org/10.1097/MBC.0000000000000735DOI Listing

[Embolic stroke immediately after initial administration of intravitreal aflibercept].

Rinsho Shinkeigaku 2018 May 28;58(5):314-319. Epub 2018 Apr 28.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University.

A 72-year-old man was admitted to our hospital because of right upper limb monoplegia 8 hours after the initial intravitreal injection of aflibercept, which is an inhibitor of vascular endothelial growth factor. Magnetic resonance diffusion-weighted images showed recent ischemic lesions in the left corona radiata and the right superior frontal gyrus. Laboratory findings showed mild hyperfibrinolysis. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001162DOI Listing
May 2018
2 Reads

ABCC6 mutations and early onset stroke: Two cases of a typical Pseudoxanthoma Elasticum.

Eur J Paediatr Neurol 2018 Jul 12;22(4):725-728. Epub 2018 Apr 12.

Rare Disease Unit, Istituto Giannina Gaslini, Genoa, Italy.

Pseudoxanthoma elasticum (PXE) is a rare genetic disorder characterized by fragmented and mineralized elastic fibers in the mid-dermis of the skin, eye, digestive tract and cardiovascular system. Clinical presentation includes typical skin lesions, ocular angioid streaks, and multisystem vasculopathy. The age of onset varies considerably from infancy to old age, but the diagnosis is usually made in young adults due to frequent absence of pathognomonic skin and ocular manifestations in early childhood. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.04.002DOI Listing
July 2018
3 Reads

Human serum albumin in cardiovascular diseases.

Authors:
Stephane Arques

Eur J Intern Med 2018 06 19;52:8-12. Epub 2018 Apr 19.

Service de Cardiologie, Centre hospitalier Edmond Garcin, Aubagne, France. Electronic address:

Cardiovascular diseases are the leading cause of death worldwide. Endothelial dysfunction, inflammation and oxidative stress are at the forefront in the onset and development of atherosclerosis and many cardiovascular diseases. Epidemiological evidence is that low serum albumin levels are linked to incident ischemic heart disease, heart failure, atrial fibrillation, stroke and venous thromboembolism, independent of risk factors, body mass index and inflammation. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.04.014DOI Listing

Protocol for a phase III, non-inferiority, randomised comparison of a new fibrinogen concentrate versus cryoprecipitate for treating acquired hypofibrinogenaemia in bleeding cardiac surgical patients: the FIBRES trial.

BMJ Open 2018 04 20;8(4):e020741. Epub 2018 Apr 20.

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Introduction: Coagulopathic bleeding is a serious complication of cardiac surgery to which an important contributor is acquired hypofibrinogenaemia (plasma fibrinogen <1.5-2.0 g/L). Read More

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http://dx.doi.org/10.1136/bmjopen-2017-020741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914770PMC
April 2018
5 Reads

Lacunar Stroke, Cavernous Angioma, and Fusiform Aneurysm Due to Irradiation for Pilocytic Astrocytoma-A Case Report.

J Stroke Cerebrovasc Dis 2018 Aug 16;27(8):e165-e167. Epub 2018 Apr 16.

Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan.

Radiotherapy is a useful modality for the treatment of brain tumors, but may induce brain degeneration, tumor formation, and vasculopathy in the irradiated field. We describe a rare case of a pediatric patient who presented multiple different types of vascular events consecutively in the irradiated field including lacunar stroke because of occlusion of perforating artery, intraventricular hemorrhage from cavernoma, and subarachnoid hemorrhage because of the rupture of fusiform aneurysm, 6 years after radiotherapy against pilocytic astrocytoma. The life-threatening aneurysm was resected, and its histologic findings revealed the radiation-induced vasculopathy. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.02.062DOI Listing
August 2018
4 Reads

Bilateral visual loss and cerebral infarction after spleen embolization in a trauma patient with idiopathic thrombocytopenic purpura: A case report.

Medicine (Baltimore) 2018 Apr;97(16):e0332

Department of Anesthesiology, Chi Mei Medical Center, Tainan.

Rationale: Splenic artery embolization (SAE) is a common procedure in trauma patients with blunt splenic injuries. We report a case of acute ischemic stroke following orthopedic surgery in a patient with post-SAE reactive thrombocytosis.

Patient Concerns: A 37-year-old woman with idiopathic thrombocytopenic purpura (ITP) suffered from multiple trauma scheduled for open reduction and internal fixation for right tibial and left radius fracture five days after SAE. Read More

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http://dx.doi.org/10.1097/MD.0000000000010332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916660PMC
April 2018
5 Reads

Intravenous Thrombolysis for Stroke Patients with G6PD Deficiency.

J Stroke Cerebrovasc Dis 2018 Jul 10;27(7):2026-2031. Epub 2018 Apr 10.

Department of Neurology, Zengcheng District People's Hospital of Guangzhou, Sun Yat-sen University, Guangzhou, Guangdong Province, China; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China. Electronic address:

Background And Purpose: No reports regarding the safety of thrombolysis in acute stroke patients with a G6PD deficiency have been published to date. Here we aimed to evaluate the safety of intravenous thrombolysis for G6PD-deficient stroke patients.

Methods: We enrolled each patient with acute ischemic stroke who arrived in our stroke unit within the therapeutic window and received systemic thrombolysis using recombinant tissue plasminogen activator (rt-PA), between January 2015 and March 2016. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.02.060DOI Listing
July 2018
2 Reads

Tyrosine kinase inhibitor induced rapidly progressive vasculopathy after intracranial stent placement.

BMJ Case Rep 2018 Apr 3;2018. Epub 2018 Apr 3.

Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, US.

Tyrosine kinase inhibitor (TKI) therapy for chronic myeloid leukemia (CML) has been associated with progressive peripheral arterial disease and, more recently, rare cases of intracranial vascular stenosis have been reported. We report the fourth case of TKI treatment associated intracranial vasculopathy and rapid progression of intracranial vascular stenosis following intracranial stent placement. This was a 49-year-old woman who developed right-sided weakness, paresthesias, numbness, and speech difficulties 7 years following TKI treatment for CML. Read More

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http://dx.doi.org/10.1136/bcr-2018-013777DOI Listing
April 2018
6 Reads

The Role of Single-Molecule Force Spectroscopy in Unraveling Typical and Autoimmune Heparin-induced Thrombocytopenia.

Int J Mol Sci 2018 Apr 2;19(4). Epub 2018 Apr 2.

Institute for Immunology and Transfusion Medicine, University Medicine of Greifswald, 17475 Greifswald, Germany.

For the last two decades, heparins have been widely used as anticoagulants. Besides numerous advantages, up to 5% patients with heparin administration suffer from a major adverse drug effect known as heparin-induced thrombocytopenia (HIT). This typical HIT can result in deep vein thrombosis, pulmonary embolism, occlusion of a limb artery, acute myocardial infarct, stroke, and a systemic reaction or skin necrosis. Read More

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http://dx.doi.org/10.3390/ijms19041054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979551PMC
April 2018
6 Reads

Inflammation in sickle cell disease.

Clin Hemorheol Microcirc 2018 ;68(2-3):263-299

Department of Medicine, Division of Hematology, Oncology and Transplantation, Vascular Biology Center, University of Minnesota, Minneapolis, MN, USA.

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant pathophysiological consequences that result in hemolytic events and the induction of the inflammatory processes that ultimately lead to vaso-occlusion. In addition to their role in the initiation of the acute painful vaso-occlusive episodes that are characteristic of SCD, inflammatory processes are also key components of many of the complications of the disease including autosplenectomy, acute chest syndrome, pulmonary hypertension, leg ulcers, nephropathy and stroke. We, herein, discuss the events that trigger inflammation in the disease, as well as the mechanisms, inflammatory molecules and cells that propagate these inflammatory processes. Read More

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http://dx.doi.org/10.3233/CH-189012DOI Listing
May 2018
3 Reads

Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: What should be our goals for transfusion therapy?

Authors:
Jon A Detterich

Clin Hemorheol Microcirc 2018 ;68(2-3):173-186

Division of Cardiology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

Sickle cell anemia is characterized by a mutation resulting in the formation of an abnormal beta-hemoglobin called hemoglobin S. Hemoglobin S polymerizes upon deoxygenation, causing impaired red blood cell deformability and increased blood viscosity at equivalent hematocrits. Thus, sickle cell disease is a hemorheologic disease that results in various pathologic processes involving multiple organ systems including the lungs, heart, kidneys and brain. Read More

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http://dx.doi.org/10.3233/CH-189006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018010PMC
May 2018
4 Reads