120,716 results match your criteria Blood Coagulation & Fibrinolysis[Journal]


Drug levels and bleeding complications in atrial fibrillation patients treated with direct oral anticoagulants.

J Thromb Haemost 2019 Apr 23. Epub 2019 Apr 23.

Arianna Anticoagulazione Foundation, Bologna, Italy.

Background: Direct oral anticoagulants (DOACs) are administered at fixed dose. Aim of the study was to evaluate the relationship between DOAC C-trough or C-peak plasma levels, and bleeding complications in patients with non-valvular atrial fibrillation (NVAF).

Methods: 565 consecutive naive NVAF patients were enrolled. Read More

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http://dx.doi.org/10.1111/jth.14457DOI Listing

[Coagulation test features depending on the AB0-blood groups system antigenic composition.]

Klin Lab Diagn 2019 ;64(3):170-175

Samara State Medical University, 43099, Samara, Russia.

The maintenance of normal blood flow through the vessels is the result of the coordinated work of the coagulation and anticoagulation systems of our body. The balance of this system depends on many factors, including endothelial, humoral, platelet ones, however, we still lack knowledge about the effect of antigenic determinants on the state of the hemostatic system. This study is devoted to assessing the effect of the presence and absence of antigens on the AB0 system, presented on erythrocyte and platelet membranes, on hemostatic parameters. Read More

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http://dx.doi.org/10.18821/0869-2084-2019-64-3-170-175DOI Listing
January 2019

Pancreatic islet surface engineering with a starPEG-chondroitin sulfate nanocoating.

Biomater Sci 2019 Apr 23. Epub 2019 Apr 23.

Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China.

Islet transplantation is one of the most promising therapeutic options that could restore euglycaemia in type 1 diabetic individuals. The currently implemented alginate microsphere islet encapsulation approach has led to positive outcomes in improving intraportal islet delivery in rodents. However, results obtained from human clinical trials remain disappointing. Read More

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http://xlink.rsc.org/?DOI=C9BM00061E
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http://dx.doi.org/10.1039/c9bm00061eDOI Listing
April 2019
1 Read

Liver stiffness and thrombin generation in compensated cirrhosis.

Res Pract Thromb Haemost 2019 Apr 28;3(2):291-297. Epub 2019 Jan 28.

Department of Hepatology Mater Misericordiae University Hospital Dublin Ireland.

Background: Decompensated cirrhosis is associated with coagulation abnormalities that can increase the risk of thrombosis and bleeding. It is unclear precisely when these abnormalities arise and whether they are exacerbated as compensated cirrhosis progresses. Transient elastography using FibroScan generates liver stiffness measurements (LSM) that associate with portal hypertension, clinical outcomes and provides prognostic information at an earlier stage than traditional liver function scores eg, MELD score. Read More

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http://doi.wiley.com/10.1002/rth2.12173
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http://dx.doi.org/10.1002/rth2.12173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462746PMC
April 2019
2 Reads

BAY 1213790, a fully human IgG1 antibody targeting coagulation factor XIa: First evaluation of safety, pharmacodynamics, and pharmacokinetics.

Res Pract Thromb Haemost 2019 Apr 14;3(2):242-253. Epub 2019 Feb 14.

CRS Clinical Research Services Wuppertal GmbH Wuppertal Germany.

Background: Coagulation factor XI (FXI) contributes to the development of thrombosis but appears to play only a minor role in hemostasis and is therefore an attractive anticoagulant drug target.

Objectives: To evaluate the safety, pharmacodynamic, and pharmacokinetic properties of BAY 1213790, a fully human immunoglobulin (Ig) G1 antibody targeting activated coagulation FXI (FXIa), in healthy men.

Methods: In this phase 1, single-blind, parallel-group, placebo-controlled, dose-escalation study, 83 healthy Caucasian men were randomized 4:1 to receive a single 60-minute intravenous infusion of BAY 1213790 (0. Read More

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http://doi.wiley.com/10.1002/rth2.12186
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http://dx.doi.org/10.1002/rth2.12186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462747PMC
April 2019
1 Read

Development of a hybrid CFD-PBPK model to predict the transport of xenon gas around a human respiratory system to systemic regions.

Heliyon 2019 Apr 10;5(4):e01461. Epub 2019 Apr 10.

School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA.

Administering incorrect doses of conventional anesthetic agents through the pulmonary route can cause potential health risks such as blood coagulation, platelet dysfunction, and deteriorating organ function. As an alternative, xenon can minimize the impact on the cardiovascular system and provide the neuroprotective effect, hemodynamic stability, and fast recovery. However, the inhalation pattern still needs to be carefully monitored and controlled to avoid health risks caused by over administering xenon to patients during unconsciousness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183704
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http://dx.doi.org/10.1016/j.heliyon.2019.e01461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460377PMC

Spontaneous Orbital Hematoma in a 2-day Old Neonate: A Case Report.

Ethiop J Health Sci 2019 Mar;29(2):291-294

Jimma University, Department of Ophthalmology, Ethiopia.

Background: Intra-orbital hematoma is an eye disease that is usually attributed to trauma, neoplasm, acute sinusitis or vascular malformations. However, spontaneous hematoma is a rare condition and can be an early manifestation of hematological disorders.

Case Report: This is a case report on a 2-days old male neonate presented with proptosis of the right eye since the second day of birth. Read More

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http://dx.doi.org/10.4314/ejhs.v29i2.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460449PMC

Hemostatic Abnormality and Associated Factors in Diabetic Patients at Jimma University Specialized Hospital, Jimma, Southwest Ethiopia: A Comparative Cross-sectional Study.

Ethiop J Health Sci 2019 Mar;29(2):251-258

School of Medical Laboratory Sciences, Jimma University, Jimma, Ethiopia.

Background: Diabetes mellitus is a group of heterogeneous disorders of multiple etiologies characterized by chronic hyperglycemia resulting from defects in insulin secretion and/or insulin action. Diabetes mellitus has been reported to disturb normal hemostasis by various mechanisms. However, data on hemostasis of diabetic patients in the study area are lacking. Read More

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http://dx.doi.org/10.4314/ejhs.v29i2.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460446PMC

Identification of significant genes with poor prognosis in ovarian cancer via bioinformatical analysis.

J Ovarian Res 2019 Apr 22;12(1):35. Epub 2019 Apr 22.

Department of Gynaecology and Obstetrics, Changhai Hospital, Navy Medical University, #168 Changhai Road, Shanghai, 200433, China.

Ovarian cancer (OC) is the highest frequent malignant gynecologic tumor with very complicated pathogenesis. The purpose of the present academic work was to identify significant genes with poor outcome and their underlying mechanisms. Gene expression profiles of GSE36668, GSE14407 and GSE18520 were available from GEO database. Read More

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http://dx.doi.org/10.1186/s13048-019-0508-2DOI Listing

Differential response of human blood leukocytes to brushite, monetite, and calcium polyphosphate biomaterials.

J Biomed Mater Res B Appl Biomater 2019 Apr 22. Epub 2019 Apr 22.

Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Calcium phosphate-based biomaterials are extensively used for bone replacement and regeneration in orthopedic, dental, and maxillofacial surgical applications. The injury induced by surgical implantation of bone replacement graft materials initiates a cascade of host responses, starting with blood-biomaterial contact, protein adsorption on the material surface, blood coagulation, and leukocyte responses. During the initial acute inflammatory response, polymorphonuclear neutrophils (PMNs) and monocytes, abundant circulating leukocytes of the myeloid lineage, are recruited to the site of inflammation. Read More

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http://dx.doi.org/10.1002/jbm.b.34385DOI Listing

Exon 2 Skipping Eliminates Gamma-Glutamyl Carboxylase Activity, Indicating a Partial Splicing Defect in a Patient with Vitamin K Clotting Factor Deficiency.

J Thromb Haemost 2019 Apr 22. Epub 2019 Apr 22.

Departments of Cardiovascular, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine at CWRU, Cleveland Clinic, 9500 Euclid Avenue NB50, Cleveland, OH, 44195.

Background: Mutations in the gamma-glutamyl carboxylase (GGCX), which is required for vitamin K-dependent (VKD) protein activation, can result in vitamin K clotting factor deficiency (VKCFD1). A recent report described a VKCFD1 patient with a homozygous carboxylase mutation that altered splicing and deleted exon 2 (Δ2GGCX). Only Δ2GGCX RNA was observed in the patient. Read More

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http://dx.doi.org/10.1111/jth.14456DOI Listing

Thromboelastography-guided Blood Product Transfusion in Cirrhosis Patients With Variceal Bleeding: A Randomized Controlled Trial.

J Clin Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.

Goals: The aim of this study was to assess the use of thromboelastography (TEG)-directed blood product transfusion in cirrhotic patients with acute variceal bleeding compared with conventional transfusion for correction of coagulopathy.

Background: Coagulopathy is common in patients with cirrhosis. Recommendations for correction of conventional parameters of coagulation-platelets and the international normalized ratio before endoscopy in patients with acute variceal bleeding-need more validation. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001214DOI Listing

Blood plasma versus serum: which is right for sampling circulating membrane microvesicles in human subjects?

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Section of Endocrinology, Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1136/annrheumdis-2019-215505DOI Listing

In vitro assessment of edoxaban anticoagulant effect in pediatric plasma.

Thromb Res 2019 Apr 13;178:112-118. Epub 2019 Apr 13.

CHU Clermont-Ferrand, Service d'Hématologie Biologique, Clermont-Ferrand, France; Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France.

Introduction: Anticoagulant therapy in pediatric patients remains an issue and safer therapies, such as direct oral anticoagulants could overcome the limitations of conventional anticoagulant treatments in this population. Edoxaban, a factor Xa inhibitor, is used for the prevention and treatment of venous thromboembolism. Due to its pharmacokinetic characteristics, edoxaban is a promising candidate molecule for children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848193020
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http://dx.doi.org/10.1016/j.thromres.2019.04.014DOI Listing
April 2019
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A comparative study of viscoelastic hemostatic assays and conventional coagulation tests in trauma patients receiving fibrinogen concentrate.

Clin Chim Acta 2019 Apr 17. Epub 2019 Apr 17.

Royal Canadian Medical Services, Ottawa, ON, Canada; McGill University, Montreal, QC, Canada.

Background: Both thrombelastography (TEG) and rotational thromboelastometry (ROTEM) have been investigated for diagnosis of coagulopathy and guidance of resuscitation in trauma and surgery. Given similarities between the two systems, it is important to determine whether one is superior to the other and how comparable they are to conventional coagulation tests (CCTs). Therefore, we conducted a comparative study of functional fibrinogen and coagulation assays using TEG and ROTEM and CCTs to determine their capability to monitor coagulation profiles, diagnose coagulopathy and predict blood transfusion requirements in trauma patients. Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.066DOI Listing

Identification of candidate nonsense mutations of FVIII for ribosomal readthrough therapy.

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA;

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http://www.haematologica.org/lookup/doi/10.3324/haematol.201
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http://dx.doi.org/10.3324/haematol.2018.205104DOI Listing
April 2019
1 Read

Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study.

Lancet Haematol 2019 Apr 16. Epub 2019 Apr 16.

Hospital Universitario La Paz, Autónoma University, Madrid, Spain.

Background: Emicizumab, a subcutaneously administered, humanised, bispecific, monoclonal antibody, is approved to treat people with haemophilia A of all ages with and without coagulation factor VIII (FVIII) inhibitors. HAVEN 4 assessed emicizumab prophylaxis administered as one dose every 4 weeks in adults and adolescents with haemophilia A, regardless of FVIII inhibitor status.

Methods: In this phase 3, multicentre, open-label, two-stage study, patients aged 12 years and older with severe congenital haemophilia A (<1% of normal FVIII activity in blood) or haemophilia A with FVIII inhibitors, undergoing treatment with either FVIII concentrates or bypassing agents were recruited from three sites in Japan and Spain for a run-in cohort, and from 17 sites in Australia, Belgium, Japan, Poland, Spain, and the USA for a subsequent expansion cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523026193005
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http://dx.doi.org/10.1016/S2352-3026(19)30054-7DOI Listing
April 2019
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Single-molecule nanomechanical spectroscopy shows calcium ions contribute to chain association and structural flexibility of blood clotting factor VIII.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China; ZhangJiang Lab, Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210, China. Electronic address:

Blood coagulation factor VIII (FVIII) can bind calcium ions and ion-protein interactions appear central importance for both their structure and function in coagulation cascade. However, the mechanism and details of how calcium dependent structure change of proteins to fulfill their function remain to be fully defined. In this work, PeakForce Quantitative Nanomechanics (PF-QNM) mode atomic force microscopy (AFM) was used to map the topography and mechanical properties of FVIII with single protein resolution under different calcium concentrations. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.068DOI Listing
April 2019
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Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures.

Biophys J 2019 Apr 2. Epub 2019 Apr 2.

Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. Electronic address:

A critical step in injury-induced initiation of blood coagulation is the formation of the complex between the trypsin-like protease coagulation factor VIIa (FVIIa) and its cofactor tissue factor (TF), which converts FVIIa from an intrinsically poor enzyme to an active protease capable of activating zymogens of downstream coagulation proteases. Unlike its constitutively active ancestor trypsin, FVIIa is allosterically activated (by TF). Here, ensemble refinement of crystallographic structures, which uses multiple copies of the entire structure as a means of representing structural flexibility, is applied to explore the impacts of inhibitor binding to trypsin and FVIIa, as well as cofactor binding to FVIIa. Read More

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http://dx.doi.org/10.1016/j.bpj.2019.03.024DOI Listing

The First Step of the Transglutaminase Reaction Catalyzed by Activated Factor XIII Subunit A, Hybrid Quantum Chemistry-Molecular Mechanics Calculations.

J Phys Chem B 2019 Apr 19. Epub 2019 Apr 19.

The A subunit of blood coagulation factor XIII belongs to the family of transglutaminase enzymes. Its active form (FXIIIa) catalyzes isopeptide bond formation between Glu and Lys residues of specific substrates. Little data is available of the mechanism of this reaction. Read More

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http://dx.doi.org/10.1021/acs.jpcb.9b00542DOI Listing
April 2019
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Biochemical Changes in Blood of Patients with Duchenne Muscular Dystrophy Treated with Granulocyte-Colony Stimulating Factor.

Biomed Res Int 2019 13;2019:4789101. Epub 2019 Mar 13.

Department of Pediatric Radiology, Medical University of Bialystok, Bialystok, Poland.

Introduction: In addition to the "gold standard" of therapy-steroids and gene therapy-there are experimental trials using granulocyte-colony stimulating factor (G-CSF) for patients with Duchenne muscular dystrophy (DMD). The aim of this study was to present the biochemical changes in blood after repeating cycles of granulocyte-colony stimulating factor G-CSF therapy in children with DMD.

Materials And Methods: Nineteen patients, aged 5 to 15 years, with diagnosed DMD confirmed by genetic tests, participated; nine were in wheelchairs, and ten were mobile and independent. Read More

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http://dx.doi.org/10.1155/2019/4789101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436375PMC

In Vitro Antiatherothrombotic Effects of Extracts from L., L., and Benth.

Evid Based Complement Alternat Med 2019 14;2019:3245836. Epub 2019 Mar 14.

Food and Science Technology Research Centre, MARDI, Serdang, Selangor, Malaysia.

Coronary artery disease is the leading cause of mortality and morbidity worldwide. The pathogenesis is mainly due to atherosclerosis, plaque rupture, and platelet thrombus formation. The main risk factors for coronary artery disease include obesity, hypercholesterolemia, smoking, diabetes, and high blood pressure. Read More

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https://www.hindawi.com/journals/ecam/2019/3245836/
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http://dx.doi.org/10.1155/2019/3245836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437728PMC
March 2019
2 Reads

Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys ().

Int J Endocrinol 2019 13;2019:2047803. Epub 2019 Mar 13.

Laboratory of Neuroscience and Behaviour, University of Brasilia, Brasilia, Brazil.

This study aimed at evaluating the availability of the primate as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female from the Primate Research Center of the University of Brasília were selected to take part in this experiment. Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment. Read More

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http://dx.doi.org/10.1155/2019/2047803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436371PMC

Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model.

Front Immunol 2019 2;10:619. Epub 2019 Apr 2.

Hematology Research Unit, GIGA-I3, GIGA Institute, University of Liège, Liège, Belgium.

Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft- vs.-host disease (GVHD). However, despite promising results in phase I/II studies, bone marrow (BM-) derived MSCs failed to demonstrate their superiority over placebo in the sole phase III trial reported thus far. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00619
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http://dx.doi.org/10.3389/fimmu.2019.00619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454068PMC
April 2019
2 Reads

Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms.

Sci Rep 2019 Apr 18;9(1):6272. Epub 2019 Apr 18.

Division of Cancer-Hull York Medical School, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.

The bidirectional association between coagulation and cancer has been established. However, anticoagulant therapies have been reported to have beneficial outcomes by influencing the vascularisation of the tumours. In this study the influence of a set of anticoagulants on tumour formation, invasion and vascularisation was examined. Read More

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http://dx.doi.org/10.1038/s41598-019-42738-1DOI Listing

Vitamin K deficiency-induced hemorrhagic shock after thoracentesis: a case report.

BMC Gastroenterol 2019 Apr 18;19(1):58. Epub 2019 Apr 18.

Honjoudaiichi Hospital, 110, Iwabuchishita, Yurihonnjou, Akita, 015-8567, Japan.

Background: Vitamin K deficiency results in serious coagulation dysfunction, but hemorrhagic shock is rare. Herein, we describe a case of vitamin K deficiency and abnormality in the path of the intercostal artery, the combination of which led to hemorrhagic shock.

Case Presentation: An 83-year-old woman was hospitalized for suspected gallstones. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0978-0DOI Listing
April 2019
1 Read

Surgical Risk on Patients with Coagulopathies: Guidelines on Hemophiliac Patients for Oro-Maxillofacial Surgery.

Int J Environ Res Public Health 2019 Apr 17;16(8). Epub 2019 Apr 17.

Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98100 Messina, Italy.

Background: Haemophilia is a disease of genetic origin, which causes a defect in blood coagulation. Under normal conditions, in the case of leakage from the blood vessels, the blood forms a clot that reduces or blocks the bleeding. This process involves the activation of several plasma proteins in a cascade-like species. Read More

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https://www.mdpi.com/1660-4601/16/8/1386
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http://dx.doi.org/10.3390/ijerph16081386DOI Listing
April 2019
1 Read

Engineered Electrospun Polyurethane Composite Patch Combined with Bi-functional Components Rendering High Strength for Cardiac Tissue Engineering.

Polymers (Basel) 2019 Apr 17;11(4). Epub 2019 Apr 17.

Media and Game Innovation Centre of Excellence (MaGICX), Institute of Human Centered Engineering (iHumEn), Universiti Teknologi Malaysia, Skudai 81310, Malaysia.

Cardiovascular application of nanomaterial's is of increasing demand and its usage is limited by its mechanical and blood compatible properties. In this work, an attempt is made to develop an electrospun novel nanocomposite loaded with basil oil and titanium dioxide (TiO) particles. The composite material displayed increase in hydrophobic and reduced fiber diameter compared to the pristine polymer. Read More

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https://www.mdpi.com/2073-4360/11/4/705
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http://dx.doi.org/10.3390/polym11040705DOI Listing
April 2019
3 Reads

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

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April 2019
2 Reads

Clampless and sutureless laparoscopic partial nephrectomy using monopolar coagulation with or without N-butyl-2-cyanoacrylate.

World J Surg Oncol 2019 Apr 17;17(1):72. Epub 2019 Apr 17.

Department of Urology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, China.

Objective: To describe a novel technique for clampless and sutureless laparoscopic partial nephrectomy (LPN) using monopolar coagulation with or without N-butyl-2-cyanoacrylate (NBCA).

Methods: From February 2015 to October 2018, we performed clampless and sutureless LPN using monopolar coagulation with or without NBCA on 142 patients. The tumors were resected with cold scissor. Read More

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http://dx.doi.org/10.1186/s12957-019-1614-8DOI Listing

Entecavir-Associated Thrombocytopenia: A Case Report and Review of the Pathophysiology, Diagnosis, and Treatment of a Rare but Reversible Cause of Thrombocytopenia.

Case Rep Hematol 2019 12;2019:4319148. Epub 2019 Mar 12.

Department of Internal Medicine, Texas Health Presbyterian Hospital, Dallas, Texas 75231, USA.

Drug-associated thrombocytopenia is often unrecognized. We report a 76-year-old female with lymphoma who presented with easy bruising and oral bleeding. She had undergone screening for hepatitis B virus (HBV) prior to starting rituximab and was found to have hepatitis B core serum antibody (IgG anti-HBc). Read More

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https://www.hindawi.com/journals/crihem/2019/4319148/
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http://dx.doi.org/10.1155/2019/4319148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434310PMC
March 2019
1 Read

Probing prothrombin structure by limited proteolysis.

Sci Rep 2019 Apr 16;9(1):6125. Epub 2019 Apr 16.

Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, 63104, USA.

Prothrombin, or coagulation factor II, is a multidomain zymogen precursor of thrombin that undergoes an allosteric equilibrium between two alternative conformations, open and closed, that react differently with the physiological activator prothrombinase. Specifically, the dominant closed form promotes cleavage at R320 and initiates activation along the meizothrombin pathway, whilst the open form promotes cleavage at R271 and initiates activation along the alternative prethrombin-2 pathway. Here we report how key structural features of prothrombin can be monitored by limited proteolysis with chymotrypsin that attacks W468 in the flexible autolysis loop of the protease domain in the open but not the closed form. Read More

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http://dx.doi.org/10.1038/s41598-019-42524-zDOI Listing

Thrombomodulin Regulation of Mitogen-Activated Protein Kinases.

Int J Mol Sci 2019 Apr 15;20(8). Epub 2019 Apr 15.

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

The multifaceted role of mitogen-activated protein kinases (MAPKs) in modulating signal transduction pathways in inflammatory conditions such as infection, cardiovascular disease, and cancer has been well established. Recently, coagulation factors have also emerged as key players in regulating intracellular signaling pathways during inflammation. Among coagulation factors, thrombomodulin, as a high affinity receptor for thrombin on vascular endothelial cells, has been discovered to be a potent anti-inflammatory and anti-tumorigenic signaling molecule. Read More

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http://dx.doi.org/10.3390/ijms20081851DOI Listing

[Clinical efficacy of Bushen Huoxue Anshen therapy in treating perimenopausal sleep disorder with kidney deficiency and blood stasis].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1069-1074

Traditional Chinese Medicine Hospital of Huairou District Beijing 101400,China.

The efficacy and safety of traditional Chinese medicine and acupuncture in the treatment of kidney-deficiency and bloodstasis perimenopausal sleep disorders were evaluated. A total of 67 subjects who completed the study were randomly divided into two groups. The traditional Chinese medicine group was orally given Bushen Huoxue Anshen Fang,and the acupuncture group was given acupuncture treatment. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181225.002DOI Listing
March 2019
1 Read

[Nature-effect relationship research of Curcumae Longae Rhizoma,Curcumae Radix,and Curcumae Rhizoma based on nature combination].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):229-234

State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.

Curcumae Longae Rhizoma,Curcumae Radix and Curcumae Rhizoma are different medicinal parts of the same plant.Nevertheless,they are different in medicinal effects due to the different Chinese herbal nature. In this study,traditional Chinese medicines database( TCMD2009),traditional Chinese medicine system( TCMSP),and Ch EMBL database were retrieved to screen the active components and targets,and construct the target PPI network. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20180903.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180903.003DOI Listing
January 2019
2 Reads

[Nature-effect relationship research of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos based on nature combination].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):224-228

State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.

Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are commonly traditional Chinese medicines with invigorating blood circulation and eliminating blood stasis,but they are different in effects due to differences in five tastes and four properties. In this study,Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos are selected as research vectors to obtain the active ingredients and targets through TCMD,TCMSP database and Ch EMBL database. The protein interaction information of the target is used to obtain from STRING online database,then imported into Cytoscape software to plot the protein interaction network and perform GO enrichment analysis. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180903.002DOI Listing
January 2019
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[Nature-effect relationship research of cold and warm medicinal properties of traditional Chinese medicine for promoting blood circulation and removing blood stasis based on nature combination].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):212-217

State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.

Traditional Chinese medicine for promoting blood circulation and removing blood stasis is a kind of drug with cold or warm medicinal properties which is commonly used in clinical practice. It is an excellent carrier for studying the nature-effect relationship of traditional Chinese medicine. Therefore,this study will acquire the main active components and targets based on the drug-based research method. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20180903.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180903.001DOI Listing
January 2019
3 Reads

[Nature-effect relationship research of traditional Chinese medicine for promoting blood circulation and removing blood stasis based on nature combination].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):205-211

State Administration of Traditional Chinese Medicine,Research Center of Traditional Chinese Medicine-Information Engineering,Beijing University of Chinese Medicine Beijing 100102,China.

The efficacy of traditional Chinese medicine is the therapeutic effect of the drug on the body. The nature of traditional Chinese medicine is a further generalization of the effect of efficacy,and there is an intrinsic relationship between efficacy and nature of traditional Chinese medicine. In this study,the nature-effect relationship is found on the whole level,through the research mode of " nature combination-targets of traditional Chinese medicine-modules of protein interaction network-efficiency". Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180913.001DOI Listing
January 2019
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[Blood-cooling and hemostasis effects of Rehmanniae Radix before and after carbonizing].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(5):954-961

College of Traditional Chinese Medicine,Shanxi University of Chinese Medicine Jinzhong 030619,China.

To compare the blood-cooling and hemostasis effects of Rehmanniae Radix before and after carbonizing on rats with blood heat and hemorrhage syndrome. The blood heat and hemorrhage syndrome rat model was established. Indexes including rectal temperature,whole blood viscosity,plasma viscosity,thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen content(FIB),red blood cell(RBC),hemoglobin(Hb),hematocrit(HCT),blood platelet count(PLT),mean platelet volume(MPV),serum IL-1,serum IL-6 and lung histopathology were detected to investigate the blood-cooling and hemostasis effects of Rehmanniae Radix and its carbonized products. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181221.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181221.007DOI Listing
March 2019
1 Read

Pancytopenia as a Consequence of Sepsis and Intravenous Antibiotic Drug Toxicity.

Cureus 2019 Feb 1;11(2):e3994. Epub 2019 Feb 1.

Internal Medicine, Ocala Regional Medical Center/ University of Central Florida College of Medicine, Ocala, USA.

This case involves a 62-year-old male with a prior history of epidural abscess and L1-L2 osteodiscitis who was admitted because of low back pain. The patient was previously treated for methicillin-susceptible Staphylococcus aureus (MSSA) discitis in the L1/L2 vertebral region with intravenous (IV) nafcillin through a peripherally inserted central catheter (PICC). However, he returned after four months with recurrent low back pain along with chills and fever. Read More

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https://www.cureus.com/articles/17399-pancytopenia-as-a-cons
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http://dx.doi.org/10.7759/cureus.3994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443538PMC
February 2019
2 Reads

Application value of thromboelastography in perioperative clinical blood transfusion and its effect on the outcome of patient.

Exp Ther Med 2019 May 1;17(5):3483-3488. Epub 2019 Mar 1.

Department of Intensive Care Unit, Central Hospital of Zibo, Zibo, Shandong 255000, P.R. China.

Application value of thromboelastography (TEG) in perioperative clinical blood transfusion and its effect on the outcome of patient were investigated. Seventy-four patients, admitted to The Surgical Department of the First Hospital of Zibo from March 2015 to March 2018, were selected for this study. Among them, 34 patients took only the traditional coagulation function testing method as the blood transfusion guide during the perioperative period and they were regarded as the control group. Read More

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http://dx.doi.org/10.3892/etm.2019.7333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447791PMC

Efficacy of Thromboelastography (TEG) in Predicting Acute Trauma-Induced Coagulopathy (ATIC) in Isolated Severe Traumatic Brain Injury (iSTBI).

Indian J Hematol Blood Transfus 2019 Apr 11;35(2):325-331. Epub 2018 Aug 11.

4Department of Emergency Medicine, Jai Prakash Narayan Apex Trauma Center, AIIMS, New Delhi, India.

To evaluate the efficacy of point-of-care thromboelastography (TEG) to predict acute trauma-induced coagulopathy (ATIC) in isolated severe TBI (iSTBI). We conducted an observational diagnostic cohort. Patients for whom TEG was performed before blood transfusion were stratified by conventional coagulation tests (CCTs) on admission and classified as "ATIC" (prothrombin time ≥ 16. Read More

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http://dx.doi.org/10.1007/s12288-018-1003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439129PMC

Reduced Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 is Associated with Disturbed Coagulation in Septic Shock.

Thromb Haemost 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

Background:  Activation of the complement system is part of the dysregulated immune response in sepsis. The mannose-binding lectin-associated serine proteases (MASP)-1 and -2 activate the lectin pathway of the complement system. Besides, these proteins can activate coagulation in vitro. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685140
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http://dx.doi.org/10.1055/s-0039-1685140DOI Listing
April 2019
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PEGAylated graphene oxide/superparamagnetic nanocomposite as a high-efficienc loading nanocarrier for controlled delivery of methotrexate.

J Biotechnol 2019 Apr 12. Epub 2019 Apr 12.

Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, 81746-73441, Iran.

Polymer-coated nanocarriers play an important role in targeted drug delivery. The use of polymers such as polyethylene glycol increases stability, biocompatibility, and blood circulation time of the drug, and may consequently improve the success of drug delivery. In the present work, a simple approach has been reported for synthesizing polyethylene glycol bis amin (PEGA) functionalized graphene oxide/iron oxide nanocomposite as a remarkable unit for loading drugs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681656193012
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http://dx.doi.org/10.1016/j.jbiotec.2019.04.006DOI Listing
April 2019
2 Reads

Impact of low volume citrate tubes on results of first-line hemostasis testing.

Int J Lab Hematol 2019 Apr 15. Epub 2019 Apr 15.

Section of Clinical Biochemistry, University of Verona, Verona, Italy.

Introduction: Pediatric tubes are increasingly used for drawing blood for hemostasis testing. This study has investigated the potential impact of low volume citrate tubes on results of first-line hemostasis testing.

Methods: The study population comprised 34 patients on warfarin therapy and 17 ostensibly healthy volunteers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijlh.13028
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http://dx.doi.org/10.1111/ijlh.13028DOI Listing
April 2019
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Trauma-Induced Coagulopathy: The Past, Present, and Future.

J Thromb Haemost 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Denver Health Medical Center and the University of Colorado, 777 Bannock Street. Mail Code 0206, Denver, CO, 80203.

Trauma remains a leading cause of death worldwide, and most early preventable deaths in both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm advances in modern trauma care. Combined tissue injury and shock result in hemostatic failure, which has been identified as a multi-dimensional molecular, physiologic, and clinical disorder termed trauma-induced coagulopathy (TIC). Understanding the biology of TIC is of utmost importance as it is often responsible for uncontrolled bleeding, organ failure, thromboembolic complications, and death. Read More

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http://dx.doi.org/10.1111/jth.14450DOI Listing
April 2019
2 Reads

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction.

J Vis Exp 2019 Apr 1(146). Epub 2019 Apr 1.

Carones Ophthalmology Center.

Dry eye disease (DED) is an increasingly common condition and one of the most common complaints of patients. The vast majority of DED is caused by the so-called "evaporative" subtype, that is mainly caused by meibomian gland dysfunction (MGD). Intense pulsed light (IPL) devices employ high intensity pulses of polychromatic lights with a broad range of wavelength (515-1200 nm). Read More

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http://dx.doi.org/10.3791/57811DOI Listing
April 2019
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Transurethral resection versus holmium laser enucleation of the prostate: A prospective randomized trial comparing perioperative thrombin generation and fibrinolysis.

Medicine (Baltimore) 2019 Apr;98(15):e15223

Department of Urology, The Second Affiliated Hospital of Zhejiang University School of Medicine.

Objectives: The purpose of this study was to compare transurethral resection of the prostate (TURP) versus holmium laser enucleation of the prostate (HoLEP) in patients with benign prostatic hyperplasia (BPH) focusing on perioperative thrombin generation and fibrinolysis.

Methods: Sixty-five BPH patients were prospectively randomly assigned to undergo TURP (n = 32) or HoLEP (n = 33). The prothrombin fragment (PF) 1+2, thrombin-antithrombin complex (TAT), tissue plasminogen activator (t-PA), and plasminogen activator inhibitor-1 (PAI-1) were measured preoperatively, at the 1st day and 3rd day after surgery. Read More

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http://dx.doi.org/10.1097/MD.0000000000015223DOI Listing

Review of herbal medications with the potential to cause bleeding: dental implications, and risk prediction and prevention avenues.

Authors:
Worku Abebe

EPMA J 2019 Mar 8;10(1):51-64. Epub 2019 Jan 8.

Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, CL-2130, Augusta, GA 30912-1128 USA.

Medicinal plant products have been used in health care since time immemorial. During the past three decades, the use of herbal supplements has been on the rise in the USA. A number of these products have been shown to possess the potential to interfere with blood clotting. Read More

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http://link.springer.com/10.1007/s13167-018-0158-2
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http://dx.doi.org/10.1007/s13167-018-0158-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459456PMC
March 2019
1 Read

The Antioxidative Action of ZTP by Increasing Nrf2/ARE Signal Pathway.

Evid Based Complement Alternat Med 2019 10;2019:5421528. Epub 2019 Mar 10.

School of Life Science, Beijing Institute of Technology, Beijing 100081, China.

So far, more than 25,000 brain diseases have been shown to be related to oxidative stress. Excessive free radicals and reactive oxygen species (ROS) can attack cells resulting in dysfunctional proteins, lipids, and nucleic acid, finally leading to imbalance of energy metabolism, cell death, gene mutation, and immune reaction. Therefore oxidative stress plays an important role in neuronal diseases. Read More

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https://www.hindawi.com/journals/ecam/2019/5421528/
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http://dx.doi.org/10.1155/2019/5421528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431467PMC
March 2019
2 Reads