72,836 results match your criteria Blood Cells Molecules & Diseases [Journal]


Decreased erythrocyte CD44 and CD58 expression link e-waste Pb toxicity to changes in erythrocyte immunity in preschool children.

Sci Total Environ 2019 Feb 5;664:690-697. Epub 2019 Feb 5.

Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, Guangdong, China; Department of Cell Biology and Genetics, Shantou University Medical College, Shantou 515041, Guangdong, China. Electronic address:

Lead (Pb) toxicity damages blood cells and disturbs the immune micro-environment. When Pb enters the circulatory system, >95% of Pb accumulates in erythrocytes. We therefore conducted this study to explore the long-term effect of Pb exposure on expression of erythrocyte adhesion molecules (CD44 and CD58) and related downstream cytokine concentrations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.040DOI Listing
February 2019

Mechanistic insights into the pH-dependent membrane peptide ATRAM.

J Control Release 2019 Feb 11. Epub 2019 Feb 11.

Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, United States. Electronic address:

pH-responsive peptides are promising therapeutic molecules that can specifically target the plasma membrane in the acidified extracellular medium that bathes cells in tumors. We designed the acidity-triggered rational membrane (ATRAM) peptide to have a pH-responsive membrane interaction. At physiological pH, ATRAM binds to the membrane surface in a largely unstructured conformation, while in acidic conditions it inserts into lipid bilayers forming a transmembrane helix. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.010DOI Listing
February 2019

Brain Endothelium: The "Innate Immunity Response Hypothesis" in Cerebral Malaria Pathogenesis.

Front Immunol 2018 29;9:3100. Epub 2019 Jan 29.

Instituto Gulbenkian de Ciência, Oeiras, Portugal.

Cerebral malaria (CM) is a life-threatening neurological syndrome caused by infection afflicting mainly children in Africa. Current pathogenesis models implicate parasite and host-derived factors in impairing brain vascular endothelium (BVE) integrity. Sequestration of -infected red blood cells (iRBCs) in brain microvessels is a hallmark of CM pathology. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361776PMC
January 2019

Brown and Brite: The Fat Soldiers in the Anti-obesity Fight.

Front Physiol 2019 30;10:38. Epub 2019 Jan 30.

Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), Bethesda, MD, United States.

Brown adipose tissue (BAT) is proposed to maintain thermal homeostasis through dissipation of chemical energy as heat by the uncoupling proteins (UCPs) present in their mitochondria. The recent demonstration of the presence of BAT in humans has invigorated research in this area. The research has provided many new insights into the biology and functioning of this tissue and the biological implications of its altered activities. Read More

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http://dx.doi.org/10.3389/fphys.2019.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363669PMC
January 2019

Stimulated release of intraluminal vesicles from Weibel-Palade bodies.

Blood 2019 Feb 13. Epub 2019 Feb 13.

Molecular and Clinical Sciences Research Institute, St George's University, London, United Kingdom

Weibel-Palade bodies (WPBs) are secretory granules that contain von Willebrand factor and P-selectin, molecules that regulate hemostasis and inflammation respectively. The presence of CD63/LAMP3 in the limiting membrane of WPBs has led to their classification as lysosome-related organelles. Many lysosome-related organelles contain intraluminal vesicles (ILVs) enriched in CD63 that are secreted into the extracellular environment during cell activation to mediate intercellular communication. Read More

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http://dx.doi.org/10.1182/blood-2018-09-874552DOI Listing
February 2019

Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies.

Molecules 2019 Feb 12;24(3). Epub 2019 Feb 12.

Radiopharmaceutical Chemistry Unit, Oncologic and High Technologies Department, Azienda USL-IRCCS, via Amendola 2, 42122 Reggio Emilia, Italy.

Colorectal cancer is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women worldwide. We have recently reported that curcuminoid complexes labelled with gallium-68 have demonstrated preferential uptake in HT29 colorectal cancer and K562 lymphoma cell lines compared to normal human lymphocytes. In the present study, we report a new gallium-68-labelled curcumin derivative (Ga-DOTA-C21) and its initial validation as marker for early detection of colorectal cancer. Read More

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http://dx.doi.org/10.3390/molecules24030644DOI Listing
February 2019

Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche.

Am J Cancer Res 2019 1;9(1):1-21. Epub 2019 Jan 1.

Department of Hepatobiliary Pancreatic Surgery, Affiliated Hospital of Qingdao University Qingdao 266003, China.

Perineural invasion (PNI) can be found in a variety of malignant tumors. It is a sign of tumor metastasis and invasion and portends the poor prognosis of patients. The pathological description and clinical significance of PNI are clearly understood, but exploration of the underlying molecular mechanism is ongoing. Read More

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January 2019

Bioengineered Let-7c Inhibits Orthotopic Hepatocellular Carcinoma and Improves Overall Survival with Minimal Immunogenicity.

Mol Ther Nucleic Acids 2019 Jan 24;14:498-508. Epub 2019 Jan 24.

Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA. Electronic address:

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths, warranting better therapies. Restoration of tumor-suppressive microRNAs depleted in hepatocellular carcinoma represents a new therapeutic strategy. Herein, we sought to identify a potent microRNA (miRNA) agent that could alleviate HCC tumor burden and improve survival. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.01.007DOI Listing
January 2019

Alteration of renal Na,K-ATPase in rats following the mediastinal γ-irradiation.

Physiol Rep 2019 Feb;7(3):e13969

Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic.

Na,K-ATPase represents the key enzyme that maintains the homeostasis of sodium and potassium ions in the cells. It was documented that in directly irradiated organs the activity of this enzyme is decreased. The aim of present study was to clarify the remote effect of irradiation in mediastinal area on the activity of the Na,K-ATPase in kidneys in rats. Read More

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http://dx.doi.org/10.14814/phy2.13969DOI Listing
February 2019

Macrophages in wound healing: activation and plasticity.

Immunol Cell Biol 2019 Feb 11. Epub 2019 Feb 11.

Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA, USA.

Macrophages are critically involved in wound healing, from dampening inflammation to clearing cell debris and coordinating tissue repair. Within the wound, the complexity of macrophage function is increasingly recognized, with adverse outcomes when macrophages are inappropriately activated, such as in fibrosis or chronic non-healing wounds. Recent advances in in vivo and translational wound models, macrophage-specific deletions and new technologies to distinguish macrophage subsets, have uncovered the vast spectrum of macrophage activation and effector functions. Read More

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http://dx.doi.org/10.1111/imcb.12236DOI Listing
February 2019

Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells.

BMC Cancer 2019 Feb 11;19(1):136. Epub 2019 Feb 11.

The Pulmonary Center, Boston University School of Medicine (BUSM), East Concord Street R304, Boston, MA, 02118, USA.

Background: MicroRNAs are noncoding RNA molecules of ~ 22 nucleotides with diagnostic and therapeutic action [Curr Drug Targets, 2015. 16(12): p. 1381-403], affecting the expression of mRNAs involved in invasion, migration, and development [Oncotarget, 2015. Read More

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http://dx.doi.org/10.1186/s12885-019-5337-6DOI Listing
February 2019

Continuous Separation of Circulating Tumor Cells from Whole Blood Using a Slanted Weir Microfluidic Device.

Cancers (Basel) 2019 Feb 10;11(2). Epub 2019 Feb 10.

Department of Electronic Engineering, Hanyang University College of Engineering, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea.

The separation of circulating tumor cells (CTCs) from the peripheral blood is an important issue that has been highlighted because of their high clinical potential. However, techniques that depend solely on tumor-specific surface molecules or just the larger size of CTCs are limited by tumor heterogeneity. Here, we present a slanted weir microfluidic device that utilizes the size and deformability of CTCs to separate them from the unprocessed whole blood. Read More

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http://dx.doi.org/10.3390/cancers11020200DOI Listing
February 2019

Applications of graphene oxide in case of nanomedicines and nanocarriers for biomolecules: review study.

Drug Metab Rev 2019 Feb 11:1-30. Epub 2019 Feb 11.

d Department of Chemical Engineering, South Tehran Branch , Islamic Azad University , Tehran , Iran.

In this Review article, recent progress progress in matter of graphene oxide (GO) synthesis and its functionalization via a vast range of materials, including small molecules, polymers, and biomolecules, were reported and systematically summarized in order to overcome the inherent drawbacks of GO nanocarriers and thereby make these nanocarriers suitable for delivering chemotherapeutic agents, genes, and short interfering RNAs. Briefly, this work describes current strategies for the large scale production of GO and modification of graphene-based nanocarriers surfaces through practical chemical approaches, improving their biocompatibility and declining their toxicity. It also describes the most relevant cases of study suitable to demonstrate the role of graphene and graphene derivatives (GD) as nanocarrier for anti-cancer drugs and genes (e. Read More

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http://dx.doi.org/10.1080/03602532.2018.1522328DOI Listing
February 2019

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.

Cell 2019 Feb 5. Epub 2019 Feb 5.

Committee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA. Electronic address:

Tissue-resident lymphocytes play a key role in immune surveillance, but it remains unclear how these inherently stable cell populations respond to chronic inflammation. In the setting of celiac disease (CeD), where exposure to dietary antigen can be controlled, gluten-induced inflammation triggered a profound depletion of naturally occurring Vγ4/Vδ1 intraepithelial lymphocytes (IELs) with innate cytolytic properties and specificity for the butyrophilin-like (BTNL) molecules BTNL3/BTNL8. Creation of a new niche with reduced expression of BTNL8 and loss of Vγ4/Vδ1 IELs was accompanied by the expansion of gluten-sensitive, interferon-γ-producing Vδ1 IELs bearing T cell receptors (TCRs) with a shared non-germline-encoded motif that failed to recognize BTNL3/BTNL8. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183165
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http://dx.doi.org/10.1016/j.cell.2018.12.039DOI Listing
February 2019
1 Read

Effect of repeated intravenous lipopolysaccharide infusions on systemic inflammatory response and endometrium gene expression in Holstein heifers.

J Dairy Sci 2019 Feb 6. Epub 2019 Feb 6.

Applied Animal Biology, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada V6T 1Z4. Electronic address:

This study aimed to evaluate the effect of repeated intravenous lipopolysaccharide (LPS) infusions in nonlactating heifers on (1) the systemic proinflammatory state as measured by biomarkers in blood and plasma, and (2) endometrial gene expression of candidate transcripts on d 15 of gestation. Our hypothesis was that target transcripts related to a major functional group would be negatively modified in the preimplantation endometrium by the LPS treatments. In the first experiment (n = 13), a systemic proinflammatory state [defined as increased plasma concentrations of tumor necrosis factor (TNF)-α and haptoglobin for 2 wk] was established using 2 different sequential LPS infusion protocols. Read More

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http://dx.doi.org/10.3168/jds.2018-14616DOI Listing
February 2019
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[Effect of Chemotherapeutic Drug-Induced Damage of Bone Marrow Stroma Cells on Normal Hematopoietic Cells].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Feb;27(1):233-238

State Key Laboratory of Experimental Hematology, Institute of Hematology &Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.E-mail:

Objective: To explore the effect of damage of bone marrow stroma cells induced by chemotherapeutic drug on the function of normal hematopoitic cells.

Methods: Senescence cells were detected by flow cytometry after SA-β-gal staining; real-time PCR was used to detect the expression of a serial molecules in bone marrow stromal cell line OP9 cells; the expression of γ-H2AX was determined by flow cytometry after histone γ-H2AX staining; the colony forming ability of hematopoietic cells was tested by colony formation assay.

Results: The percentage of senescence cells in OP9 cells after DNR treatment was 2. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2019.01.038DOI Listing
February 2019

The effect of nacre extract on cord blood-derived endothelial progenitor cells: a natural stimulus to promote angiogenesis?

J Biomed Mater Res A 2019 Feb 8. Epub 2019 Feb 8.

CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), UMR 7365, Vandœuvre-Lès-Nancy, F-54505, France.

Angiogenesis is a critical parameter to consider for the development of tissue-engineered bone substitutes. The challenge is to promote sufficient vascularization in the bone substitute to prevent cell death and to allow its efficient integration. The capacity of nacre extract to restore the osteogenic activity of osteoarthritis osteoblasts has already been demonstrated. Read More

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http://dx.doi.org/10.1002/jbm.a.36655DOI Listing
February 2019
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Improving the Production of Cofactor-Containing Proteins: Production of Human Hemoglobin in Yeast.

Methods Mol Biol 2019 ;1923:243-264

Department of Biology and Biological Engineering, Systems and Synthetic Biology, Chalmers University of Technology, Gothenburg, Sweden.

Human hemoglobin is an essential protein, whose main function as an oxygen carrier is indispensable for life. Hemoglobin is a cofactor-containing protein with heme as prosthetic group. Same as in humans, heme is synthesized in many organisms in a complex pathway involving two cellular compartments (mitochondria and cytosol), which is tightly regulated. Read More

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http://dx.doi.org/10.1007/978-1-4939-9024-5_11DOI Listing
January 2019
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Strategies for the measurements of expression levels and half-lives of HLA class I allotypes.

Hum Immunol 2019 Feb 5. Epub 2019 Feb 5.

Department of Laboratory Medicine and Pathology, Mayo Clinic, 5777 E. Mayo Blvd, Phoenix, AZ 85054, USA.

HLA class I molecules are highly polymorphic cell surface proteins that trigger immune responses by CD8 T cells and natural killer (NK) cells. Most humans express six different HLA class I proteins encoded by the HLA-A, HLA-B and HLA-C genes. HLA class I molecules bind to peptide antigens and present these antigens to T cell receptors (TCR) of CD8 T cells. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.001DOI Listing
February 2019

Wheat phenolics suppress doxorubicin-induced cardiotoxicity via inhibition of oxidative stress, MAP kinase activation, NF-κB pathway, PI3K/Akt/mTOR impairment, and cardiac apoptosis.

Food Chem Toxicol 2019 Feb 6;125:503-519. Epub 2019 Feb 6.

Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address:

The present investigation has been undertaken to reveal the protective mechanism of polyphenolics extract of whole wheat grains (WWGPE), ferulic acid and apigenin against doxorubicin (Dox)-induced cardio-toxicity. WWGPE, apigenin, and ferulic acid exhibited concentration dependent cyto-protective effect against Dox (1 μM) in rat cardiomyocytes. Dox treatment significantly (p < 0. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.034DOI Listing
February 2019

Increased Levels of miR-155 are Related to Higher T-Cell Activation in the Peripheral Blood of Patients with Chronic Hepatitis B.

Genet Test Mol Biomarkers 2019 Feb;23(2):118-123

2 Department of Infectious Diseases, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Objectives: MicroRNA-155 (miR-155) is an important regulator of immune responses in humans. However, its role in T-cell activation in hepatitis B virus (HBV) infection remains unclear.

Materials And Methods: Eighty-one patients with chronic hepatitis B (CHB), 77 HBV carriers, and 51 healthy controls were recruited. Read More

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http://dx.doi.org/10.1089/gtmb.2018.0092DOI Listing
February 2019

A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene.

PLoS Genet 2019 Feb 7;15(2):e1007961. Epub 2019 Feb 7.

University of Rostock, Department of Neurology, Division of Neuroimmunology, Rostock, Germany.

Genome-wide association studies have identified more than 200 genetic variants to be associated with an increased risk of developing multiple sclerosis (MS). Still, little is known about the causal molecular mechanisms that underlie the genetic contribution to disease susceptibility. In this study, we investigated the role of the single-nucleotide polymorphism (SNP) rs1414273, which is located within the microRNA-548ac stem-loop sequence in the first intron of the CD58 gene. Read More

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http://dx.plos.org/10.1371/journal.pgen.1007961
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http://dx.doi.org/10.1371/journal.pgen.1007961DOI Listing
February 2019
4 Reads

Beta Cell-Derived Angiopoietin-1 Regulates Insulin Secretion and Glucose Homeostasis by Stabilizing Islet Microenvironment.

Diabetes 2019 Feb 6. Epub 2019 Feb 6.

Department of Internal Medicine

Islets are highly vascularized for prompt insulin secretion. Although angiopoietin-1 (Ang1) is a well-known angiogenic factor, its role in glucose homeostasis remains largely unknown. The objective of this study was to investigate whether and how Ang1 contributes to glucose homeostasis in response to metabolic challenge. Read More

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-0864DOI Listing
February 2019
2 Reads

Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression.

Arthritis Res Ther 2019 Feb 6;21(1):50. Epub 2019 Feb 6.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

Background: Acute gouty arthritis currently is the most common form of inflammatory arthritis in developed countries. Treatment is still suboptimal. Dosage of urate-lowering therapy is often too low to reach target urate levels, and adherence to therapy is poor. Read More

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http://dx.doi.org/10.1186/s13075-019-1834-xDOI Listing
February 2019
1 Read

HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics.

J Immunother Cancer 2019 Feb 6;7(1):33. Epub 2019 Feb 6.

NYU Langone Health, 522 First Avenue, 1306 Smilow Research Building, New York, NY, 10016, USA.

Background: Therapies targeting anti-tumor T-cell responses have proven successful in the treatment of a variety of malignancies. However, as most patients still fail to respond, approaches to augment immunotherapeutic efficacy are needed. Here, we investigated the ability of histone deacetylase 6 (HDAC6)-selective inhibitors to decrease immunosuppression and enhance immune function of melanoma patient T-cells in ex vivo cultures. Read More

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http://dx.doi.org/10.1186/s40425-019-0517-0DOI Listing
February 2019
1 Read

T Cell Checkpoint Regulators in the Heart.

Cardiovasc Res 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

T lymphocyte-mediated immune responses in the heart are potentially dangerous because they can interfere with the electromechanical function. Furthermore, the myocardium has limited regenerative capacity to repair damage caused by effector T cells. Myocardial T cell responses are normally suppressed by multiple mechanisms of central and peripheral tolerance. Read More

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https://academic.oup.com/cardiovascres/advance-article/doi/1
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http://dx.doi.org/10.1093/cvr/cvz025DOI Listing
February 2019
3 Reads

Advances in nanocarriers enabled brain targeted drug delivery across blood brain barrier.

Int J Pharm 2019 Feb 2;559:360-372. Epub 2019 Feb 2.

Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea; Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore Rd, Kolkata, West Bengal 700126, India. Electronic address:

The blood brain barrier (BBB) offers protection to the central nervous system (CNS) by maintaining homeostasis. Besides restricting the entry of harmful xenobiotics and endogenous molecules to CNS, BBB also limits the entry of therapeutic agents. Nanotechnology offers the possibility to deliver small molecules/drugs against CNS disorders across BBB. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193009
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http://dx.doi.org/10.1016/j.ijpharm.2019.01.056DOI Listing
February 2019
7 Reads

Investigation of Permeation of Theophylline through Skin Using Selected Piperazine-2,5-Diones.

Molecules 2019 Feb 4;24(3). Epub 2019 Feb 4.

Regional Centre of Advanced Technologies and Materials, Palacky University, Slechtitelu 27, 783 71 Olomouc, Czech Republic.

Transdermal administration of drugs that penetrate, in this case directly into the blood circulation, has many advantages and is promising for many drugs thanks to its easy application and good patient compliance. ()-8-Methyl-6,9-diazaspiro[4.5]decan-7,10-dione (alaptide), has been studied as a potential chemical permeation enhancer. Read More

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http://dx.doi.org/10.3390/molecules24030566DOI Listing
February 2019

Anti-colorectal cancer targets of resveratrol and biological molecular mechanism: Analyses of network pharmacology, human and experimental data.

J Cell Biochem 2019 Feb 5. Epub 2019 Feb 5.

Department of Pharmacology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.

In this study, colorectal cancer (CRC)-diseased targets and resveratrol (Res)-associated targets were combined and constructed by the use of grouped databases for identification of the predicted targets. After production of target-functional protein interaction network of Res anti-CRC, the topological analysis was used to create the core targets of Res anti-CRC. All core targets performed the analyses of biological function and pathway enrichment to optimize the biological processes and key signaling pathways of Res anti-CRC. Read More

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http://dx.doi.org/10.1002/jcb.28404DOI Listing
February 2019
1 Read
3.263 Impact Factor

An essential role for the Zn transporter ZIP7 in B cell development.

Nat Immunol 2019 Feb 4. Epub 2019 Feb 4.

Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

Despite the known importance of zinc for human immunity, molecular insights into its roles have remained limited. Here we report a novel autosomal recessive disease characterized by absent B cells, agammaglobulinemia and early onset infections in five unrelated families. The immunodeficiency results from hypomorphic mutations of SLC39A7, which encodes the endoplasmic reticulum-to-cytoplasm zinc transporter ZIP7. Read More

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http://www.nature.com/articles/s41590-018-0295-8
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http://dx.doi.org/10.1038/s41590-018-0295-8DOI Listing
February 2019
3 Reads

P-glycoprotein Inhibitor Tariquidar Potentiates Efficacy of Astragaloside IV in Experimental Autoimmune Encephalomyelitis Mice.

Molecules 2019 Feb 3;24(3). Epub 2019 Feb 3.

Shanghai Key Laboratory of Compound Chinese Medicines, the Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, the State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

ATP-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), often reduce drug efficacy and are the major cause of drug resistance. Astragaloside IV (ASIV), one of the bioactive saponins isolated from , has been demonstrated to alleviate the progression of experimental autoimmune encephalomyelitis (EAE) in mice, an animal model for multiple sclerosis (MS). In the present study, we found for the first time that ASIV induced the upregulation of P-gp and BCRP in the central nervous system (CNS) microvascular endothelial cells of EAE mice. Read More

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http://dx.doi.org/10.3390/molecules24030561DOI Listing
February 2019
2 Reads
2.416 Impact Factor

Fraxinellone inhibits inflammatory cell infiltration during acute pancreatitis by suppressing inflammasome activation.

Int Immunopharmacol 2019 Feb 1;69:169-177. Epub 2019 Feb 1.

Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 540-749, South Korea; Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, Iksan, Jeonbuk 54538, South Korea. Electronic address:

Inflammasomes promote the production of pro-inflammatory cytokines, such as interleukin (IL)-1β and IL-18, which are the representative mediators of inflammation. Abnormal activation of inflammasomes leads to the development of inflammatory diseases such as acute pancreatitis (AP). In this study, we demonstrate the inhibitory effects of a new natural compound fraxinellone on inflammasome formation and examine the role of inflammasomes in a mouse model of AP. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.043DOI Listing
February 2019
1 Read

PTP1B Inhibition, A Promissing Approach For The Treatment Of Diabetes Type Ii.

Curr Top Med Chem 2019 Feb 1. Epub 2019 Feb 1.

Department of Pharmacy School of Health, Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, 54124. Greece.

Background: Diabetes mellitus (DM), is a metabolic disorder characterized by high blood glucose levels. The main types of diabetes mellitus are Diabetes mellitus type I, Diabetes mellitus type II, gestational diabetes and Diabetes of other etiology. Diabetes type II, the non insulin dependent type (NIDDM) is the most common type, characterized by the impairment in activation of the intracellular mechanism leading to the insertion and usage of glucose after interaction of insulin with its receptor, known as insulin resistance. Read More

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http://dx.doi.org/10.2174/1568026619666190201152153DOI Listing
February 2019
3.402 Impact Factor

Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5.

Oncoimmunology 2019 2;8(2):e1534664. Epub 2018 Nov 2.

Laboratory of Transplantation Immunotherapy, Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA.

Although the proteasome inhibitor bortezomib has significantly improved the survival of patients with multiple myeloma (MM), the disease remains fatal as most patients eventually develop progressive disease. Recent data indicate that MM cells can evade bortezomib-induced cell death by undergoing autophagy as a consequence of endoplasmatic reticulum (ER)-stress induced by proteasome inhibition. Here we show that bortezomib sensitizes MM cells to NK cell killing via two distinct mechanisms: a) upregulation of the TRAIL death receptor DR5 on the surface of MM cells and b) ER-stress induced reduction of cell surface HLA-E. Read More

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http://dx.doi.org/10.1080/2162402X.2018.1534664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343814PMC
November 2018
1 Read

Early high levels of regulatory T cells and T helper 1 may predict the progression of recurrent hepatitis C after liver transplantation.

Clin Res Hepatol Gastroenterol 2019 Jan 31. Epub 2019 Jan 31.

Sorbonne Universités, UPMC Université Paris 06, INSERM, UMR_S 938, Saint-Antoine Research Center, 75012 Paris, France; AP-HP, Pitié-Salpêtrière hospital, Unité Médicale de Transplantation Hépatique, 75013 Paris, France.

Background: Immune response failure against hepatitis C virus (HCV) has been associated with an increased regulatory T cell (Treg) activity. After liver transplantation (LT), 80% of patients experience an accelerated progression of hepatitis C recurrence. The aim of this work was to assess the involvement of Tregs, T helper (Th) 1, 2 and 17 cells in recurrent hepatitis C. Read More

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http://dx.doi.org/10.1016/j.clinre.2018.10.005DOI Listing
January 2019
1 Read

Leucine-glycine and carnosine dipeptides prevent diabetes induced by multiple low-dose streptozotocin in experimental model of adult mice.

J Diabetes Investig 2019 Feb 2. Epub 2019 Feb 2.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Aims/introduction: Peptides are considered as quasi-hormones and effective molecules for regulation of the cells function and metabolic disorders prevention. Di- and tripeptides with the ability to gastrointestinal absorption have been proposed to prevent diabetes progression.

Materials And Methods: Small peptides with different sequences of specific amino acids were synthesized based on a solid phase peptide synthesis (SPPS) protocol as well as carnosine (A) and glutathione (B) were examined for the prevention of diabetes induced by multiple low-dose of streptozotocin (MLDS) in mice. Read More

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http://dx.doi.org/10.1111/jdi.13018DOI Listing
February 2019

PepN is a non-essential, cell wall-localized protein that contributes to neutrophil elastase-mediated killing of Streptococcus pneumoniae.

PLoS One 2019 1;14(2):e0211632. Epub 2019 Feb 1.

Department of Biological Sciences, Towson University, Towson, MD, United States of America.

Streptococcus pneumoniae (Spn) is an asymptomatic colonizer of the human nasopharynx but can also cause disease in the inner ear, meninges, lung and blood. Although various mechanisms contribute to the effective clearance of Spn, opsonophagocytosis by neutrophils is perhaps most critical. Upon phagocytosis, Spn is exposed to various degradative molecules, including a family of neutrophil serine proteases (NSPs) that are stored within intracellular granules. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211632PLOS
February 2019
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Effect of mirabegron on tight junction molecules in primary cultured rat Sertoli cells.

Andrologia 2019 Jan 31:e13241. Epub 2019 Jan 31.

Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.

Mirabegron is a selective beta3-adrenoceptor (β -AR) agonist, which is commonly used for the treatment of overactive bladder. This medicine is associated with atrophy of reproductive organs in rats. However, no study has examined the detailed action and mechanism of its toxicity in reproductive cells. Read More

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http://dx.doi.org/10.1111/and.13241DOI Listing
January 2019
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Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance.

Immunogenetics 2019 Jan 31. Epub 2019 Jan 31.

Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, College Station, TX, 77843, USA.

Major histocompatibility complex (MHC) class I and class II molecules play critical roles in the activation of the adaptive immune system by presenting antigens to CD8+ and CD4+ T cells, respectively. Although it has been well known that CIITA (MHC class II transactivator), an NLR (nucleotide-binding domain, leucine-rich-repeat containing) protein, as a master regulator of MHC class II gene expression, the mechanism of MHC class I gene transactivation was unclear. Recently, another NLR protein, NLRC5 (NLR family, CARD domain-containing 5), was identified as an MHC class I transactivator (CITA). Read More

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http://dx.doi.org/10.1007/s00251-019-01106-zDOI Listing
January 2019

Cytokine and Adhesion Molecule Expression Induced by Different Strains of in Type 1 Diabetic Rats: Role of Insulin.

Front Immunol 2018 17;9:3165. Epub 2019 Jan 17.

Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences (FCF), University of São Paulo (USP), São Paulo, Brazil.

may provoke peritonitis and death, especially in immunocompromized individuals such as diabetic patients. We evaluated the role of insulin in -induced peritoneal infection in diabetic and non-diabetic rats. Alloxan-diabetic male Wistar rats and their respective controls received intraperitoneal injections of different strains of or sterile phosphate-buffered saline. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344427PMC
January 2019
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Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga .

Molecules 2019 Jan 29;24(3). Epub 2019 Jan 29.

Department of Pharmacology, Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia.

Three new rare C acetogenins (enyne derivatives ⁻) were isolated from the organic extract obtained from the red alga , collected from the Red Sea. The chemical structures of the isolated compounds were established by spectroscopical data analyses. Potent anti-inflammatory effect of the isolated metabolites was evidenced by inhibition of the release of inflammatory mediators (e. Read More

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http://dx.doi.org/10.3390/molecules24030476DOI Listing
January 2019

Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma.

Blood 2019 Jan 29. Epub 2019 Jan 29.

Signal Transduction in Tumor Cells, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany;

Persistent NF-κB activation is a hallmark of the malignant Hodgkin/Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL). Genomic lesions, Epstein-Barr virus infection, soluble factors and tumor-microenvironment interactions contribute to this activation. Here, in an unbiased approach to identify the cHL cell-secreted key factors for NF-κB activation, we have dissected the secretome of cultured cHL cells by chromatography and subsequent mass spectrometry. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-08
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http://dx.doi.org/10.1182/blood-2018-08-871293DOI Listing
January 2019
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The Emerging Role of Bone Markers in Diagnosis and Risk Stratification of Patients With Coronary Artery Disease.

Angiology 2019 Jan 29:3319718822625. Epub 2019 Jan 29.

6 First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Molecules that govern bone metabolism, such as osteoprotegerin (OPG) and osteopontin (OPN), have been isolated from other tissues, including blood vessels. Atherosclerosis and coronary artery disease (CAD) are leading causes of mortality worldwide. Despite novel biochemical and imaging techniques, early detection of CAD is still unsatisfactory. Read More

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http://dx.doi.org/10.1177/0003319718822625DOI Listing
January 2019

PDL1 Fusion Protein Protects Against Experimental Cerebral Malaria via Repressing Over-Reactive CD8 T Cell Responses.

Front Immunol 2018 14;9:3157. Epub 2019 Jan 14.

Department of Immunology, Fourth Military Medical University, Xi'an, China.

Cerebral malaria (CM), mainly caused by (.), is one of the most lethal complications of severe malaria. As immunopathology mediated by brain-infiltrating CD8 T cells is the major pathogenesis of CM, there is no safe and efficient treatment clinically focused on CD8 T cells. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339951PMC
January 2019
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Inflammatory expression profile in peripheral blood mononuclear cells from patients with Nasu-Hakola Disease.

Cytokine 2019 Apr 25;116:115-119. Epub 2019 Jan 25.

University of Milan, Centro Dino Ferrari, Milan, Italy; Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.

Homozygous mutations in Triggering Receptor Expressed on Myeloid cells 2 gene (TREM2) are one of the major causes of Nasu Hakola Disease (NHD). We analysed Peripheral Blood Mononuclear Cells (PBMC) profile of 164 inflammatory factors in patients with NHD carrying the TREM2 Q33X mutation as compared with heterozygous and wild type individuals. Several molecules related to bone formation and angiogenesis were altered in NHD compared to non-carriers: Bone Morphogenetic Protein (BMP)-1 mRNA levels were significantly increased in PBMC (2. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.024DOI Listing

Unravelling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit?

Int J Parasitol 2019 Jan 26. Epub 2019 Jan 26.

Department of Microbiology, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia. Electronic address:

The global impact of bovine babesiosis caused by the tick-borne apicomplexan parasites Babesia bovis, Babesia bigemina and Babesia divergens is vastly underappreciated. These parasites invade and multiply asexually in bovine red blood cells (RBCs), undergo sexual reproduction in their tick vectors (Rhipicephalus spp. for B. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00207519183030
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http://dx.doi.org/10.1016/j.ijpara.2018.11.002DOI Listing
January 2019
4 Reads

Natural Compound Oridonin Inhibits Endotoxin-Induced Inflammatory Response of Activated Hepatic Stellate Cells.

Biomed Res Int 2018 30;2018:6137420. Epub 2018 Dec 30.

Department of Surgery, University of Texas Medical Branch, Galveston, Texas, 77555, USA.

Hepatic stellate cells (HSCs) play an important role in hepatic fibrogenesis and inflammatory modulation. Endotoxin is dramatically increased in portal venous blood after serious injury and can contribute to liver damage. However, the mechanism underlying endotoxin's effects on HSCs remains largely unknown. Read More

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http://dx.doi.org/10.1155/2018/6137420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330820PMC
December 2018

A Phase 2 Study to Assess the Immunomodulatory Capacity of a Lecithin-based Delivery System of Curcumin in Endometrial Cancer.

Front Nutr 2018 11;5:138. Epub 2019 Jan 11.

Laboratory of Gynaecologic Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.

Curcumin is a botanical with anti-tumor and immunomodulatory properties. We hypothesized that curcumin supplementation might influence inflammatory biomarker levels in endometrial carcinoma (EC). In this open-label, non-randomized phase 2 study (NCT02017353), seven EC patients consumed 2 g/day Curcumin Phytosome (CP) orally for 2 weeks. Read More

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https://www.frontiersin.org/article/10.3389/fnut.2018.00138/
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http://dx.doi.org/10.3389/fnut.2018.00138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336921PMC
January 2019
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A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4 CD25 FOXP3 Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition.

Front Immunol 2018 10;9:3119. Epub 2019 Jan 10.

Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.

Previous studies showed that single-chain fusion proteins comprised of GM-CSF and major encephalitogenic peptides of myelin, when injected subcutaneously in saline, were potent tolerogenic vaccines that suppressed experimental autoimmune encephalomyelitis (EAE) in rats and mice. These tolerogenic vaccines exhibited dominant suppressive activity in inflammatory environments even when emulsified in Complete Freund's Adjuvant (CFA). The current study provides evidence that the mechanism of tolerance was dependent upon vaccine-induced regulatory CD25 T cells (Tregs), because treatment of mice with the Treg-depleting anti-CD25 mAb PC61 reversed tolerance. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335336PMC
January 2019

Extracellular Vesicles Secreted by Astroglial Cells Transport Apolipoprotein D to Neurons and Mediate Neuronal Survival Upon Oxidative Stress.

Front Cell Neurosci 2018 10;12:526. Epub 2019 Jan 10.

Instituto de Biología y Genética Molecular-Departamento de Bioquímica y Biología Molecular y Fisiología, Universidad de Valladolid-CSIC, Valladolid, Spain.

Extracellular vesicle (EV)-mediated glia-to-neuron communication has been recognized in a growing number of physiological and pathological situations. They transport complex sets of molecules that can be beneficial or detrimental for the receiving cell. As in other areas of biology, their analysis is revolutionizing the field of neuroscience, since fundamental signaling processes are being re-evaluated, and applications for neurodegenerative disease therapies have emerged. Read More

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http://dx.doi.org/10.3389/fncel.2018.00526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335244PMC
January 2019