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    Ocular manifestation and their associated factors among HIV/AIDS patients receiving highly active antiretroviral therapy in Southern Ethiopia.
    Int J Ophthalmol 2017 18;10(5):776-781. Epub 2017 May 18.
    School of medicine, College of Medicine and Health Sciences, Hawassa University, Hawassa P.O.box 1560, Ethiopia.
    Aim: To assess the pattern of ocular manifestation and associated factors among human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients on highly active antiretroviral therapy (HAART) at Hawassa University Referral Hospital, Southern Ethiopia.

    Methods: A cross sectional study was conducted from January 2014 to April 2015. After obtaining informed written consent, 240 adult HIV/AIDS patients on HAART were randomly selected regardless of their ophthalmic symptoms, WHO status or CD4 count. Read More

    Conjunctivochalasis and Related Factors in an Adult Population of Iran.
    Eye Contact Lens 2017 Mar 24. Epub 2017 Mar 24.
    Noor Ophthalmology Research Center (H.H.), Noor Eye Hospital, Tehran, Iran; Department of Epidemiology and Biostatics (H.R., A.F.), School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; and Center for Health Related Social and Behavioral Sciences Research (M.H.E.), Shahroud University of Medical Sciences, Shahroud, Iran.
    Objectives: To determine the prevalence of conjunctivochalasis and its determinants in a middle-aged Iranian population.

    Methods: This population-based study was conducted in the context of the second phase of Shahroud Eye Cohort Study in 2014. Of 4,737 participants aged 45 to 69 years who participated in the second phase, the data of 4,702 participants were available for this report. Read More

    Demodex spp. Infestation Associated with Treatment-Resistant Chalazia and Folliculitis.
    Turkiye Parazitol Derg 2016 Dec;40(4):208-210
    Yıldırım Beyazıt Üniversitesi Yenimahalle Eğitim ve Araştırma Hastanesi, Tıbbi Mikrobiyoloji Kliniği, Ankara, Türkiye.
    Demodecidosis is an ectoparasitosis of pilosebaceous unit caused by demodex mites. The disease may be a primary skin disease or a secondary disease to inflammatory dermatoses such as folliculitis and rosacea. Demodex spp. Read More

    [Eye lid hygiene in chronic allergic blepharoconjunctivitis patients before laser refractive surgery].
    Vestn Oftalmol 2016;132(5):86-92
    Research Institute - Krasnodar Regional Hospital No. 1 named after Prof. S.V. Ochapovsky, Krasnodar, Russian Federation.
    Aim: To evaluate the effectiveness of eyelid hygiene in patients with chronic allergic blepharoconjunctivitis (ABC) as a part of their preparation for laser refractive surgery.

    Material And Methods: The study involved 32 patients (12 males and 20 females aged 25-42 years) with refractive errors, namely, compound myopic astigmatism (23 patients) and hyperopic astigmatism (9 patients) suffering from chronic ABC and secondary dry eye syndrome (DES). All the patients initially received a standard treatment for ABC and DES, that is olopatodin hydrochloride instillations - 1 mg/ml 2 times daily, preservative-free hyaluronic acid preparation - 1 mg/ml 3 times daily, and polyacrylic acid and dexpanthenol gel at night for one month. Read More

    Ice compresses aid the reduction of swelling and pain after scleral buckling surgery.
    J Clin Nurs 2016 Nov 22;25(21-22):3261-3265. Epub 2016 Aug 22.
    Department of Ophthalmology of The Second Xiangya Hospital, Central South University, Changsha, China.
    Aims And Objectives: To investigate the therapeutic effects of a local ice compress in alleviating eyelid swelling and errhysis and providing relief from pain after surgery.

    Background: Eyelid swelling and pain are the most common postoperative symptoms after scleral buckling surgery. A local ice compress can reduce the severity of swelling, errhysis and pain after acute injury as well as after surgery. Read More

    Functional and Morphologic Changes of Meibomian Glands in an Asymptomatic Adult Population.
    Invest Ophthalmol Vis Sci 2016 Aug;57(10):3996-4007
    Brien Holden Vision Institute University of New South Wales, Sydney, New South Wales, Australia 2Vision CRC, Sydney, New South Wales, Australia 3School of Optometry & Vision Science, University of New South Wales, Sydney, New South Wales, Australia.
    Purpose: The aim of the study was to understand natural changes of meibomian glands (MG) that occur with aging in the absence of any ocular pathology or ocular discomfort symptoms, to differentiate between "age normal" and pathologic or dysfunctional changes of the MG.

    Methods: A total of 185 subjects (109 females) with no pre-existing ocular and systemic abnormalities were recruited and divided into four age groups: 25 to 34, 35 to 44, 45 to 54, and 55 to 66 years. At a single visit, the following MG measures were collected: meibum quality (MQ) and MG expressibility (MGE) of the lower lid, and MG drop-out score (meiboscale) using infrared meibography of the upper and lower lids. Read More

    Ocular Surface Disease in Breast Cancer Patients Using Aromatase Inhibitors.
    Breast J 2016 Sep 14;22(5):561-3. Epub 2016 Jun 14.
    1st Department of Ophthalmology, University of Athens, Athens, Greece.
    Aromatase inhibitors (AIs) are widely used as adjuvant hormonal therapy in postmenopausal women with hormone receptor-positive breast cancer. The purpose of this study was to investigate the potential impact of AIs on the anterior segment of the eye and especially the ocular surface. Participants in our study were 41 hormone receptor-positive early stage breast cancer patients (80 eyes), treated with AIs, while 80 eyes of 40 age- and gender-matched healthy controls, not previously used AIs for any purpose, were also evaluated. Read More

    Irregularly luscious lashes: difficult to say but a sinister sign to miss.
    BMJ Case Rep 2016 May 20;2016. Epub 2016 May 20.
    Russells Hall Hospital, Dudley, UK.
    We present a case of an 84-year-old man with advanced glaucoma on multiple unilateral glaucoma medication. He had 2 years history of unilateral ocular irritation thought to be related to his medication. Patient was referred to an oculoplastic clinic and found to have segmental eyelash loss partially masked by hypertrichosis caused by glaucoma medications. Read More

    BACTERIOLOGY AND RISK FACTORS OF BACTERIAL KERATITIS IN JIMMA, SOUTHWEST ETHIOPIA.
    Ethiop Med J 2015 Oct;53(4):191-7
    Background: In East Africa, particularly in Ethiopia, bacterial keratitis is a major cause of blindness.

    Objective: The aims of this study were to identify risk factors of bacterial keratitis and the spectrum of bacterial etiologies, and to assess the in-vitro antimicrobial susceptibility of these bacterial isolates at Jimma University Specialized Hospital, Southwest Ethiopia.

    Methods: A prospective study was employed from January 2012 to June 2012 from which a total of 24 patients with bacterial keratitis were included in the study. Read More

    Development of Herpes Simplex Virus Infectious Epithelial Keratitis During Oral Acyclovir Therapy and Response to Topical Antivirals.
    Cornea 2016 May;35(5):692-5
    Department of Ophthalmology, New York University (NYU) School of Medicine, NYU Langone Medical Center, New York, NY.
    Purpose: To describe 3 cases of herpes simplex virus (HSV) vesicular blepharitis that progressed to infectious epithelial keratitis despite treatment with oral acyclovir, but responded to topical antiviral therapy.

    Methods: Retrospective review of a small case series.

    Results: One adult and 2 children presented with unilateral HSV vesicular blepharitis without evidence of corneal involvement. Read More

    [Clinical manifestations of 172 patients with blepharokeratoconjunctivitis].
    Zhonghua Yan Ke Za Zhi 2016 Mar;52(3):174-9
    Beijing Institute of Ophthalmology, Beijing Tongren Ophthalmic Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.
    Objective: To summarize the clinical characteristics, diagnosis, and treatment of blepharokeratoconjunctivitis (BKC).

    Methods: Retrospective analysis. One hundred and seventy-two patients were diagnosed as BKC between January 2012 and December 2014 at Beijing Tongren Hospital. Read More

    Over 25 Years of Clinical Experience With Ivermectin: An Overview of Safety for an Increasing Number of Indications.
    J Drugs Dermatol 2016 Mar;15(3):325-32
    Although the broad-spectrum anti-parasitic effects of the avermectin derivative ivermectin are well documented, its anti-inflammatory activity has only recently been demonstrated. For over 25 years, ivermectin has been used to treat parasitic infections in mammals, with a good safety profile that may be attributed to its high affinity to invertebrate neuronal ion channels and its inability to cross the blood-brain barrier in humans and other mammals. Numerous studies report low rates of adverse events, as an oral treatment for parasitic infections, scabies and head lice. Read More

    [A new classification for meibomian gland diseases with in vivo confocal microscopy].
    J Fr Ophtalmol 2016 Mar 16;39(3):239-47. Epub 2016 Feb 16.
    Service d'ophtalmologie III, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Centre d'investigations cliniques Inserm-DHOS CIC 1423, centre hospitalier national d'ophtalmologie des Quinze-Vingts, DHU vision et handicaps, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, université de Versailles Saint-Quentin-en-Yvelines, 75012 Versailles, France.
    Introduction: Meibomian gland dysfunction (MGD) is a frequent disorder often associated with dry eye disease. Slit-lamp examination with digital expression of the tarsal Meibomian glands allows examination of the contents of the distal Meibomian gland and the meatus. However, the Meibomian epithelium, interglandular space and proximal secretions cannot be clinically assessed. Read More

    Demodex treatment in external ocular disease: the outcomes of a Tasmanian case series.
    Int Ophthalmol 2016 Oct 2;36(5):691-6. Epub 2016 Feb 2.
    Tasmanian Eye Institute, 36 Thistle St West, South Launceston, TAS, 7249, Australia.
    Demodex species (spp.) have previously been implicated in the pathogenesis of blepharitis. This study aims to correlate improvement in symptoms of external ocular disease with treatment of underlying Demodex spp. Read More

    Ocular Findings of Myotonic Dystrophy Type 1 in the Korean Population.
    Graefes Arch Clin Exp Ophthalmol 2016 Jun 27;254(6):1189-93. Epub 2016 Jan 27.
    Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
    Purpose: To investigate ocular findings in a Korean population with myotonic dystrophy type 1 (DM1).

    Methods: A total of 24 Korean patients with DM1, ranging in age from 4 to 71 years, were examined over a period from June 2004 to May 2014. Ophthalmologic examinations including visual acuity assessment, slit-lamp biomicroscopy, ocular motility, cycloplegic refraction, and fundus examination were performed in all patients, and brain magnetic resonance (MR) imaging was performed in 15 patients. Read More

    The Effect of Demodex Infestation on Blepharitis and the Ocular Symptoms.
    Eye Contact Lens 2017 Jan;43(1):64-67
    Department of Ophthalmology (N.K., A.Ş.D., M.A., T.B., C.G.), Ministry of Health, Yildirim Beyazit Research and Education Hospital, Ankara, Turkey; and Department of Ophthalmology (E.U.K.), Dr. Sami Ulus Maternity and Children Research and Education Hospital, Ankara, Turkey.
    Objective: This study aimed to determine the frequency of Demodex infestation of eyelashes in patients with and without blepharitis and to determine the effects of Demodex infestation on blepharitis and the ocular symptoms.

    Methods: The study included patients with chronic mixed (anterior + posterior) blepharitis who presented to our clinic. Patients with refractive error and no ocular disease were enrolled as the control group. Read More

    Syndrome in question.
    An Bras Dermatol 2015 Nov-Dec;90(6):909-11
    Faculdade Evangélica do Paraná, Curitiba, PR, Brazil.
    Morbihan Syndrome is a rare entity with unknown etiology. It is clinically characterized by chronic erythematous edema on the face - especially in the middle and upper third of the face - and creates abnormal facial contours that are initially intermitent but become permanent with the development of the syndrome. The histopathology is nonspecific and its therapy is a major challenge due to poor response to the various treatment options. Read More

    Long-term Natural History of Dry Eye Disease from the Patient's Perspective.
    Ophthalmology 2016 Feb 21;123(2):425-33. Epub 2015 Nov 21.
    Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Division of Preventive Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology & Visual Sciences, Center for Translational Medicine, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah. Electronic address:
    Purpose: To describe the natural history of dry eye disease (DED), which chronically affects millions of people in the United States.

    Design: This study is based on the Women's Health Study and Physicians' Health Studies, and uses questionnaires and medical records.

    Participants: A total of 398 men and 386 women who reported a diagnosis of DED and responded to a questionnaire about change in disease since diagnosis. Read More

    [Lipoid proteinosis (Urbach-Wiethe's Disease)].
    Kulak Burun Bogaz Ihtis Derg 2015 ;25(6):357-60
    Department of Pathology, Kayseri Training and Research Hospital, 38010 Kocasinan, Kayseri, Turkey.
    A 25-year-old female patient was admitted to our outpatient clinic with postpartum hoarseness. Punch biopsy specimens obtained from the larynx and sublingual region revealed multi-folded squamous epithelium with a hyperkeratosis pattern and amorphous hyaline material aggregation. This aggregation was also remarkable around the vessels. Read More

    Primary cutaneous extranodal marginal zone B-cell lymphoma of the eyelid skin: Diagnostic clues and distinction from other ocular adnexal diseases.
    Surv Ophthalmol 2016 May-Jun;61(3):333-8. Epub 2015 Nov 3.
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Ophthalmic Plastic Surgery, Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, USA.
    A 60-year-old man developed a rubbery thickening and erythema of his left lateral upper and lower eyelids and lateral canthus over several months. He was treated for an extended period of time for blepharitis and chalazia. Incisional biopsy eventually disclosed microscopically a hypercellular lymphoid population sparing the epidermis that surrounded adnexal structures and infiltrated between orbicularis muscle fibers. Read More

    Pyoblepharitis Vegetans in Association With Pyodermatitis-Pyostomatitis Vegetans: Expanding the Spectrum of a Rare, Multisystem Disorder.
    J Cutan Med Surg 2016 Mar-Apr;20(2):163-5. Epub 2015 Oct 30.
    Division of Dermatology, University of Calgary, Calgary, Alberta, Canada
    Background: Pyodermatitis-pyostomatitis vegetans (PDPSV) is a rare inflammatory disorder of the skin and oral mucosa that is commonly associated with inflammatory bowel disease (IBD). Ocular involvement is uncommon.

    Objective: Given the association with IBD, it is important for dermatologists to be aware of the varying manifestations of PDPSV. Read More

    Granulomatous nephritis and dermatitis in a patient with BRAF V600E mutant metastatic melanoma treated with dabrafenib and trametinib.
    Melanoma Res 2015 Dec;25(6):550-4
    Departments of aMedical Oncology bNephrology cPathology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
    A 61-year-old man was diagnosed with stage IIIB BRAF V600E mutant melanoma in October 2012. He was treated with a combination therapy of dabrafenib and trametinib. He remained in complete remission for 18 months and the treatment was well tolerated after dose reduction because of pyrexia. Read More

    Common Blepharitis Related to Phthiriasis Palpebrarum: Argon Laser Phototherapy.
    Turkiye Parazitol Derg 2015 Sep;39(3):252-4
    Department of Ophthalmology, Mersin University, Mersin, Turkey.
    A 42-year-old woman was admitted to Mersin University, Department of Ophthalmology Clinic with itching and burning sensation of the right eye for 3 weeks. In her slit-lamp examination, nits and lice, attached to the upper and lower eyelashes of her right eye, were observed. Lice and nits were destroyed by argon laser phototherapy and were removed with the help of a fine forceps thereafter. Read More

    Erlotinib-related keratopathy in a patient underwent laser in situ keratomileusis.
    Cutan Ocul Toxicol 2016 Sep 12;35(3):257-9. Epub 2015 Aug 12.
    b Department of Ophthalmology , Taipei Veterans General Hospital and National Yang Ming University , Taipei , Taiwan.
    Erlotinib is a tyrosine kinase inhibitor of the epidermal growth factor receptor. Since there is a wide expression of the epidermal growth factor receptors in the epithelial tissues of ocular surface and adnexa, ocular adverse reactions may happen during systemic administration of erlotinib. Previously reported ocular adverse reactions of erlotinib include trichomegaly, periorbital rash, ectropion, blepharitis, persistent corneal epithelial defect, corneal ulcer and perforation. Read More

    One-year clinical evaluation of 0.4% ripasudil (K-115) in patients with open-angle glaucoma and ocular hypertension.
    Acta Ophthalmol 2016 Feb 4;94(1):e26-34. Epub 2015 Sep 4.
    Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan.
    Purpose: To investigate the intra-ocular pressure (IOP)-lowering effects and safety of 0.4% ripasudil (K-115), a Rho kinase inhibitor, twice daily for 52 weeks, in patients with open-angle glaucoma or ocular hypertension (OHT).

    Methods: In this multicentre, prospective, open-label study, 388 patients with primary open-angle glaucoma, OHT or exfoliation glaucoma were enrolled and 354 of them were subdivided into four cohorts (monotherapy, 173; additive therapy to prostaglandin analogs, 62; β-blockers, 60; or fixed combination drugs, 59). Read More

    Ophthalmologic findings in contact sport disciplines.
    J Sports Med Phys Fitness 2016 Dec 2;56(12):1598-1601. Epub 2015 Sep 2.
    Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
    Background: The aim of the study was to investigate the prevalence and the incidence of ocular complications in contact sport disciplines in a large population of professional and amateur athletes over a period of 3 years.

    Methods: We performed a retrospective review of 694 medical records from athletes examinated from 2008 to 2011. The following data were collected during the routine visit for agonistic sports eligibility: medical history, age, weight, years of sport practice, approximate number of matches, head and eyes injuries during and beyond of the match and a through ocular history. Read More

    Detection of Acanthamoeba on the ocular surface in a Spanish population using the Schirmer strip test: pathogenic potential, molecular classification and evaluation of the sensitivity to chlorhexidine and voriconazole of the isolated Acanthamoeba strains.
    J Med Microbiol 2015 Aug;64(8):849-53
    1​University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda Astrofísico Fco. Sánchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain.
    Pathogenic strains of Acanthamoeba are causative agents of a sight-threatening infection of the cornea known as Acanthamoeba keratitis, which is often associated with the misuse of contact lenses. However, there is still a question remaining to be answered, which is whether these micro-organisms are present on the ocular surface of healthy individuals. Therefore, the aim of this study was to determine the presence of Acanthamoeba on the ocular surface in healthy patients and also in those with other ocular surface infections. Read More

    Periodic acid-Schiff staining demonstrates fungi in chronic anterior blepharitis.
    Eye (Lond) 2015 Dec 21;29(12):1522-7. Epub 2015 Aug 21.
    Department of Ophthalmology, Mevlana University School of Medicine, Konya, Turkey.
    Purpose: To evaluate the presence of fungi in patients with chronic anterior blepharitis with periodic acid-Schiff (PAS) staining of the eyelashes in addition to the conventional methods of fungal cultures and direct microscopy.

    Methods: Nineteen patients with chronic anterior blepharitis of seborrheic or mixed seborrheic/staphylococcal type and 11 healthy age- and sex-matched controls were included in this prospective, nonrandomized, cross-sectional study. Blepharitis was diagnosed based on clinical evidence of greasy scales between the cilia, lid margin erythema, conjunctival hyperemia, telangiectasia, thickening, or irregularity of the eyelid margins by slit-lamp biomicroscopy. Read More

    Demodex sp. as a Potential Cause of the Abandonment of Soft Contact Lenses by Their Existing Users.
    Biomed Res Int 2015 21;2015:259109. Epub 2015 Jul 21.
    Department of General Biology and Parasitology, Medical University of Warsaw, Ulica Chałubińskiego 5, 02-004 Warsaw, Poland ; Institute of Parasitology, Polish Academy of Sciences, Ulica Twarda 51/55, 00-818 Warsaw, Poland.
    Demodex mites may be a potential etiological factor in the development of various eye and skin disorders. The aim of the study was to investigate the presence of Demodex in the hair follicles of eyelashes and their potential influence on abandoning soft contact lenses which had been previously well tolerated by their users. A group of 62 users of contact lenses (28 with emerging discomfort and 34 without discomfort) were examined. Read More

    Bacterial isolates and their antimicrobial susceptibility pattern among patients with external ocular infections at Borumeda hospital, Northeast Ethiopia.
    BMC Ophthalmol 2015 Aug 14;15:103. Epub 2015 Aug 14.
    Department of Medical Microbiology, School of Biomedical and Laboratory sciences, CMHS, UOG, P.O. box 196, Gondar, Ethiopia.
    Background: Bacteria are major cause of ocular infections and possible loss of vision. The emergence of antimicrobial resistant bacteria increases the risk of treatment failure with potentially serious consequences. The aim of this study was to determine the prevalence of bacterial isolates and their antimicrobial susceptibility pattern among patients with external ocular infections. Read More

    Ocular Manifestations of Acquired Immunodeficiency Syndrome.
    Korean J Ophthalmol 2015 Aug 21;29(4):241-8. Epub 2015 Jul 21.
    Department of Ophthalmology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
    Purpose: To investigate the patterns and risk factors of the ocular manifestations of acquired immunodeficiency syndrome (AIDS) and their correlation with CD4+ count in the era of highly active antiretroviral therapy (HAART).

    Methods: This retrospective study examined 127 AIDS patients who presented to Soonchunhyang University Hospital. Data were collected from patient interviews, clinical examinations, and laboratory investigations. Read More

    Epidemiology and Outcomes of Kocuria Keratitis.
    Eye Contact Lens 2016 Sep;42(5):e20-4
    Department of Cornea and Refractive Surgery (L.P-A., A.R-M., A.N., E.O.G-H.), Instituto de Oftalmologia "Fundación Conde De Valenciana" IAP, Mexico City, Mexico; and Microbiology and Ocular Proteomics, Research Unit (V.M.B-d.L., M.O-C.), Instituto de Oftalmologia "Fundación Conde De Valenciana" IAP, Mexico City, Mexico.
    Objective: To determine the characteristics of infectious keratitis caused by Kocuria spp.

    Methods: Retrospective case series. Information included demographic data, medical history, risk factors associated with infectious keratitis, clinical characteristics, microbiological results and drug sensitivity, clinical course, management, and visual outcomes. Read More

    Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease.
    JAMA Ophthalmol 2015 Oct;133(10):1117-23
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas.
    Importance: Topical application of azithromycin suppresses expression of proinflammatory mediators while restoring transforming growth factor β1 (TGF-β1) levels as evaluated by eyelid margin and conjunctival impression cytology.

    Objective: To explore the effects of azithromycin therapy on expression of proinflammatory and anti-inflammatory mediators in meibomian gland disease (MGD).

    Design, Setting, And Participants: Case-control study performed in a clinic setting from August 17, 2010, to December 31, 2010. Read More

    Efficacy and Safety of Topical Atorvastatin for the Treatment of Dry Eye Associated with Blepharitis: A Pilot Study.
    Ophthalmic Res 2015 5;54(1):26-33. Epub 2015 Jun 5.
    Save Sight Institute, University of Sydney, Sydney, N.S.W., Australia.
    Aims: To elucidate if topically applied atorvastatin safely decreases corneal fluorescein staining in dry eyes associated with blepharitis.

    Methods: Ten dry eye and blepharitis (DEB) patients were enroled in a prospective pilot study. All patients were treated with topical atorvastatin (50 μM) 8 times a day for 4 weeks and allowed to continue with their existing dry eye treatment. Read More

    [Bacterial flora in blepharitis].
    J Fr Ophtalmol 2015 Oct 14;38(8):723-8. Epub 2015 May 14.
    Service de bactériologie, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours, France; UMR1282 ISP, université François-Rabelais de Tours, 37032 Tours, France; INRA, UMR1282 ISP, 37380 Nouzilly, France.
    Introduction: Blepharitis has multiple, poorly defined origins. The goal of this study was to investigate the bacterial flora present in patients affected with blepharitis in comparison with healthy subjects, so as to understand the role of bacterial etiologies in blepharitis.

    Materials And Methods: Fifty-four patients with blepharitis and 50 healthy controls participated in this study. Read More

    [Demodex spp in chronic blepharitis patients].
    Rev Chilena Infectol 2015 Feb;32(1):37-42
    Background: Blepharitis is a very common disease in the ophthalmologic practice generally taking a chronic course with intermittent exacerbations. Several studies have linked the presence of Demodex folliculorum with chronic blepharitis, since the mite has the capacity to perpetuate the follicular inflammatory process. The prevalence of infection by Demodex spp. Read More

    Variability of Tear Osmolarity in Patients With Dry Eye.
    JAMA Ophthalmol 2015 Jun;133(6):662-7
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia.
    Importance: Knowledge about the variability of measurements using the TearLab Osmolarity System is necessary when evaluating the clinical utility of readings.

    Objective: To examine the variability of tear osmolarity measured by the TearLab Osmolarity System in patients with Sjögren syndrome (SS), patients with blepharitis, and control participants.

    Design, Setting, And Participants: Cross-sectional study at a tertiary care academic center from June 13, 2012, to March 21, 2013. Read More

    Long-Term Bleb-Related Infections After Trabeculectomy: Incidence, Risk Factors, and Influence of Bleb Revision.
    Am J Ophthalmol 2015 Jun 5;159(6):1082-91. Epub 2015 Mar 5.
    Jules Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address:
    Purpose: To report the incidence of late-onset bleb-related infections and to identify risk factors for bleb-related infections after trabeculectomy for the treatment of glaucoma.

    Design: Retrospective case series.

    Methods: Bleb-related infections were defined as blebitis, endophthalmitis, or blebitis with endophthalmitis. Read More

    Conjunctival geographic ulcer: an overlooked sign of herpes simplex virus infection.
    J Clin Virol 2015 Mar 5;64:40-4. Epub 2015 Jan 5.
    Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
    Herpes simplex virus (HSV) ocular infection causes significant visual burden worldwide. Despite the fact that dendritic or geographic corneal ulcers are typical findings in HSV epithelial keratitis, conjunctival ulcer as a sign of HSV infection has rarely been reported. Although easily overlooked, this important sign could be enhanced by fluorescein staining. Read More

    A case of pachyonychia congenita with unusual manifestations: an unusual type or a new syndrome?
    Int J Dermatol 2015 Mar 29;54(3):334-7. Epub 2013 Oct 29.
    Ankara Numune Education and Research Hospital, Dermatology Department, Ankara, Turkey.
    A 30-year-old man presented with lesions on his oral mucosa and soles. There were no similar complaints in his family members. The dermatological examination revealed follicular hyperkeratosis on his trunk and upper extremities and flesh-colored, firm cystic lesions on his axillae. Read More

    [Treatment of chronic allergic blepharoconjunctivitis].
    Vestn Oftalmol 2014 Sep-Oct;130(5):78, 80-4
    Objective: to evaluate the effectiveness of therapeutic eyelid hygiene in the treatment of chronic, or perennial, allergic blepharoconjunctivitis (ABC).

    Material And Methods: A total of 30 patients with chronic ABC (11 men, 19 women aged 25-41 years; disease duration 2-4 years) were examined before and after a treatment course which included instillations of olopatodine hydrochloride instillations (1 mg/ml, 2 times daily) and hyaluronic acid (2 mg/ml, 3-4 times daily). Patients from the main group (18 patients, 36 eyes) additionally practiced therapeutic eyelid hygiene using Blepharoshampoo, Blepharolotion or Blepharosalfetka, and Blepharogel-1 (2 times daily). Read More

    Prospective study of ocular manifestations of pemphigus and bullous pemphigoid identifies a high prevalence of dry eye syndrome.
    Cornea 2015 Apr;34(4):443-8
    *Faculty of Medicine, University of New South Wales, Sydney Australia; †Department of Ophthalmology, Prince of Wales Hospital, Sydney, Australia; ‡Department of Dermatology, St George Hospital, Sydney, Australia; and §Ophthalmic Surgeons, Sydney, Australia.
    Purpose: To study the range of ocular manifestations in an Australian cohort of patients with pemphigus and bullous pemphigoid (BP), including a detailed assessment for dry eye syndrome (DES).

    Methods: Twenty-two patients with pemphigus vulgaris, pemphigus foliaceus, and BP were referred for a detailed ophthalmology review between September 2011 and March 2012.

    Results: A total of 44 eyes of 22 patients with pemphigus vulgaris, pemphigus foliaceus, and BP were examined. Read More

    Orbital apex syndrome: an unusual complication of herpes zoster ophthalmicus.
    BMC Infect Dis 2015 Jan 31;15:33. Epub 2015 Jan 31.
    Division of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
    Background: Herpes zoster ophthalmicus is defined as herpes zoster involvement of the ophthalmic division of the trigeminal nerve. Ocular involvement occurs in 20-70% of patients with herpes zoster ophthalmicus and may include blepharitis, keratoconjunctivitis, iritis, scleritis, and acute retinal necrosis. Orbital apex syndrome is a rare but severe ocular complication of herpes zoster ophthalmicus. Read More

    Refractive outcome of wavefront guided laser in situ keratomileusis and wavefront guided photorefractive keratectomy in high pre-existing higher order aberration.
    Cont Lens Anterior Eye 2015 Apr 30;38(2):127-33. Epub 2014 Dec 30.
    Guru Nanak Eye Centre, Maharaja Ranjit Singh Marg, New Delhi 110002, India.
    Purpose: To compare visual outcome and higher order aberrations (HOA) between wavefront-guided LASIK (WF-LASIK) and wavefront guided PRK (WF-PRK) in patients with high preoperative HOA.

    Methods: Randomized prospective interventional study. Conducted at Guru Nanak Eye Centre, Maulana Azad Medical College, Delhi, India. Read More

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