1,842 results match your criteria Blepharitis Adult


Clinical factors associated with contact lens dropout.

Cont Lens Anterior Eye 2018 Dec 8. Epub 2018 Dec 8.

Centre for Ocular Research and Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.

Purpose: Contact lens (CL) dropout is estimated to be approximately equal to the number of new wearers per year, resulting in virtually no growth in the global CL market. The purpose of this study was to determine ocular and CL factors associated with CL dropout.

Methods: This five-site study recruited subjects 18-45 years of age who had ceased CL wear within the past 6-12 months due to discomfort. Read More

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December 2018

Periocular Manifestations of Afatinib Therapy.

Ophthalmic Plast Reconstr Surg 2018 Dec 4. Epub 2018 Dec 4.

Oxford University Hospital, Headley Way, Headington, Oxford, United Kingdom.

Epidermal growth factor receptor tyrosine kinase inhibitor therapy has been increasingly employed in the treatment of a variety of tumors. The authors report the rarely documented side effect of trichiasis with the use of Afatinib in a patient with spinal chordoma and review-related literature. A 67-year-old lady was referred to the oculoplastic service with a 3-month history of ocular irritation and pain associated with blurred vision. Read More

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December 2018

Investigating the subjective cooling effect of eyelid cleansing gel on eyelid and ocular surface temperature.

Cont Lens Anterior Eye 2018 Dec 7. Epub 2018 Dec 7.

Ophthalmic Research Group, School of Life & Health Sciences, Aston University, Birmingham, B4 7ET, United Kingdom; Thea Pharmaceuticals Limited, Keele University Science & Innovation Park, Newcastle-Under-Lyme, ST5 5NT, United Kingdom.

Purpose: To investigate if the application of Blephagel, an eyelid cleansing gel, causes subjective and/or objective cooling effects by measuring ocular symptomology and temperature.

Methods: Twenty-five healthy subjects underwent baseline non-invasive temperature measurements on the closed upper eyelid (centrally, nasally, and temporally) and ocular surface temperature (OST) on both eyes using an infrared camera. A standard application of Blephagel was then applied to the closed upper eyelid and eyelashes with a sterile cotton-wool to one eye selected at random. Read More

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December 2018

The Ocular Status of Cystinosis Patients Receiving a Hospital Pharmacy-Made Preparation of Cysteamine Eye Drops: A Case Series.

Ophthalmol Ther 2018 Dec 5. Epub 2018 Dec 5.

Manchester Royal Eye Hospital, Manchester Academic Health Science Centre, Manchester, UK.

Introduction: Infantile nephropathic cystinosis (INC) is an autosomal recessive lysosomal disorder in which patients develop deposits of cystine crystals in their kidneys and corneas from a young age.

Methods: We conducted a retrospective analysis of children with INC seen by ophthalmologists at the Manchester Royal Eye Hospital between 2002 and 2018, to evaluate clinical findings, symptoms and treatment.

Results: Twenty-two children diagnosed with INC from age 0 (prenatally) to 11 years were assessed. Read More

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December 2018
6 Reads

The epidemiology of nonviral microbial keratitis in a tertiary care center in Muscat, Oman.

Oman J Ophthalmol 2018 Sep-Dec;11(3):213-219

Department of Ophthalmology, Al-Nahdah Hospital, Muscat, Oman.

Objective: The objective of this study is to describe the epidemiology, risk factors, etiology, and outcome of microbial keratitis in a tertiary care center in Muscat, Oman.

Methods: The electronic records of all patients diagnosed with keratitis or corneal ulcer between January 2013 and January 2016 in Al-Nahdha Hospital were retrospectively reviewed. Patients who presented with a corneal ulcer requiring admission and who underwent culture and sensitivity studies were included in the study. Read More

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December 2018
1 Read

[Modern methods of evaluating the morphological and functional state of the eyelids in chronic blepharitis].

Vestn Oftalmol 2018 ;134(5. Vyp. 2):276-281

I.M. Sechenov First Moscow State Medical University, Chair of Ophthalmology, 8-2 Malaya Trubetskaya St., Moscow, Russian Federation, 119991.

The article reviews the literature on methods of evaluating the morphological and functional state of the eyelids in chronic blepharitis. Development of methods continues together with further research on the etiology and pathogenesis of the disease. Read More

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January 2018

Challenges in the Polyene- and Azole-Based Pharmacotherapy of Ocular Fungal Infections.

J Ocul Pharmacol Ther 2018 Nov 8. Epub 2018 Nov 8.

1 Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi , Oxford, Mississippi.

Polyenes and azoles constitute 2 major drug classes in the antifungal armamentarium used to treat fungal infections of the eye such as fungal keratitis, endophthalmitis, conjunctivitis, and blepharitis. These classes of drugs have come to occupy an important niche in ophthalmic antifungal therapy due to their broad spectrum of activity against a variety of filamentous and yeast-like fungi. Natamycin suspension (Natacyn), a polyene antifungal drug, is currently the only US FDA-approved formulation for treating ophthalmic fungal infections, whereas the other polyene and azole antifungals such as amphotericin B, fluconazole, itraconazole, ketoconazole, miconazole, voriconazole, and posaconazole are routinely used off-label in the clinical setting. Read More

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November 2018
3 Reads

Healthcare delivery in meibomian gland dysfunction and blepharitis.

Authors:
Soh R Tong L

Ocul Surf 2018 Nov 17. Epub 2018 Nov 17.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore National Eye Center, Singapore; Singapore Eye Research Institute, Singapore; Duke-NUS Medical School, Singapore. Electronic address:

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November 2018

Ocular Surface Disease in Birds.

Authors:
Angela Griggs

Vet Clin North Am Exot Anim Pract 2019 Jan;22(1):53-68

North Houston Veterinary Ophthalmology, 1646 Spring Cypress Road, Suite 116, Spring, TX 77388, USA. Electronic address:

Avian ocular disease may be primary or a manifestation of systemic disease. Various infectious and noninfectious diseases have been reported to cause ocular pathology. Thorough physical examination and diagnostic testing are necessary to determine a treatment plan. Read More

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January 2019
1 Read

Severe chronic blepharitis. Torpid evolution of several years.

Enferm Infecc Microbiol Clin 2018 Nov 15. Epub 2018 Nov 15.

Unidad de Gestión Clínica de Oftalmología, Hospital Juan Ramón Jiménez, Huelva, España.

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November 2018

Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.

Genet Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen Medical Center (Radboudumc), Nijmegen, The Netherlands.

Purpose: We aimed to assess the biological and clinical significance of the human cysteine protease inhibitor cystatin M/E, encoded by the CTS6 gene, in diseases of human hair and skin.

Methods: Exome and Sanger sequencing was performed to reveal the genetic cause in two related patients with hypotrichosis. Immunohistochemical, biophysical, and biochemical measurements were performed on patient skin and 3D-reconstructed skin from patient-derived keratinocytes. Read More

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November 2018
4 Reads

Microbiological Evaluation of Bandage Soft Contact Lenses Used in Management of Persistent Corneal Epithelial Defects.

Cornea 2018 Nov 12. Epub 2018 Nov 12.

Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To investigate the rate and agents of contamination in bandage soft contact lenses fitted for management of persistent corneal epithelial defects.

Methods: This prospective comparative case series enrolled 57 consecutive eyes fitted with bandage contact lenses for treatment of persistent corneal epithelial defects. The lenses were collected at the time of epithelial closure or when it was necessary to exchange contact lenses and were immediately placed in sterile tubes containing an enriched thioglycolate liquid medium. Read More

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November 2018
4 Reads

Air Pollution and Non-Communicable Diseases: A review by the Forum of International Respiratory Societies' Environmental Committee. Part 2: Air pollution and organ systems.

Chest 2018 Nov 9. Epub 2018 Nov 9.

School of Earth, Society, and Environment, Department of Atmospheric Sciences, University of Illinois, Urbana, IL, USA.

Although air pollution is well-known to be harmful to the lung and airways, it can also damage most other organ systems of the body. It is estimated that about 500,000 lung cancer deaths and 1.6 million chronic obstructive pulmonary disease (COPD) deaths can be attributed to air pollution, but air pollution may also account for 19% of all cardiovascular deaths and 21% of all stroke deaths. Read More

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November 2018
6 Reads

Association of Blepharitis and Ectropion With Tumor Necrosis Factor α Inhibitor Treatment in Crohn Disease.

JAMA Ophthalmol 2018 Nov 8. Epub 2018 Nov 8.

Department of Ophthalmology and Visual Science, Kellogg Eye Center, University of Michigan, Ann Arbor.

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November 2018
5 Reads

Risk Factors for Eye Disorders Caused by Paclitaxel: A Retrospective Study.

Biol Pharm Bull 2018 ;41(11):1694-1700

Department of Digestive Surgery, Kyoto Okamoto Memorial Hospital.

Paclitaxel and nanoparticle albumin-bound paclitaxel are known to cause adverse events of eye disorders, such as cystoid macular edema. However, at present, the risk factors remain unclear. Therefore, risk factors for eye disorders caused by paclitaxel and nanoparticle albumin-bound paclitaxel were studied. Read More

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January 2018
1 Read

Blepharitis Preferred Practice Pattern®.

Ophthalmology 2018 Oct 23. Epub 2018 Oct 23.

Departments of Cornea and External Diseases, Scripps Clinic Torrey Pines, La Jolla, California.

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October 2018
4 Reads

Occurrence of Demodex species in patients with blepharitis and in healthy individuals: a 10-year observational study.

Jpn J Ophthalmol 2018 Nov 25;62(6):628-633. Epub 2018 Sep 25.

Department of Microbiology, Wroclaw Medical University, Chalubinskiego Street 4, 50-368, Wrocław, Poland.

Purpose: Two Demodex species (eyelash mites)-D. folliculorum and D brevis-are believed to be associated with human skin and eye diseases. However, the clinical significance of infection with Demodex species remains controversial. Read More

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November 2018
4 Reads

Comparing the in vitro effects of MGO Manuka honey and tea tree oil on ocular Demodex viability.

Cont Lens Anterior Eye 2018 Dec 7;41(6):527-530. Epub 2018 Jul 7.

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand. Electronic address:

Purpose: To compare the in vitro antiparasitic effects of MGO Manuka honey and tea tree oil against ocular Demodex.

Methods: Fifty-two viable Demodex mites were acquired from the epilated eyelashes of 9 participants with blepharitis and symptomatic dry eye. Viable mites were randomised to one of five treatment groups: cyclodextrin-complexed and uncomplexed Manuka Honey, 100% and 50% tea tree oil, and no treatment. Read More

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December 2018
1 Read
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The utility of a normal tear osmolarity test in patients presenting with dry eye disease like symptoms: A prospective analysis.

Cont Lens Anterior Eye 2018 Sep 17. Epub 2018 Sep 17.

Weill Cornell Medicine, Department of Ophthalmology, New York, NY, USA.

Objective: To explore the diagnostic utility of normal tear osmolarity in patients with symptoms suggestive of dry eye disease (DED).

Methods: Prospective observational cohort study of 100 patients that underwent tear osmolarity testing (TearLab) if they endorsed one or more symptoms of potential DED. Patients were included for the study if they had a normal tear osmolarity test (value <308 mOsm/L in each eye, and an inter-eye difference <8 mOsm/L). Read More

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September 2018
4 Reads

Short-term Efficacy and Safety of a Latanoprost/Carteolol Fixed Combination Switched From Concomitant Therapy to in Patients With Primary Open-angle Glaucoma or Ocular Hypertension.

J Glaucoma 2018 Dec;27(12):1175-1180

Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan.

Purpose: We prospectively investigated the efficacy and safety of switching from concomitant latanoprost and carteolol hydrochloride (CH) to a latanoprost/carteolol fixed combination (LCFC) in patients with primary open-angle glaucoma or ocular hypertension.

Patients And Methods: A total of 43 patients (43 eyes) who were using latanoprost (once daily in the evening) and CH (once daily in the morning) concomitantly were switched to LCFC (once daily in the morning) with no washout interval. The primary efficacy endpoint was change in intraocular pressure (IOP) between baseline (before switching) and 1 and 3 months after switching. Read More

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December 2018

Phthiriasis palpebrarum presenting as anterior blepharitis.

Authors:
Taskin Khan

Indian J Public Health 2018 Jul-Sep;62(3):239-241

Assistant Professor, Department of Ophthalmology, Hamdard Institute of Medical Sciences and Research, Hamdard University, New Delhi, India.

In humans, Pthirus pubis or crab louse usually infests hair of pubic region. Phthiriasis palpebrarum (infestation of the eyelashes and eyelids) is not as rare as is reported in literature, especially in low socioeconomic communities. It is possible that the disease is being perhaps missed due to its clinical similarity with anterior blepharitis. Read More

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September 2018
5 Reads

blepharitis: clinical perspectives.

Clin Optom (Auckl) 2018 4;10:57-63. Epub 2018 Jul 4.

Department of Clinical Education, Illinois College of Optometry, Chicago, IL, USA,

and are two mites which infest the human eye and which may, in excess, lead to a wide range of anterior segment findings. mites have been implicated in anterior and posterior blepharitis, blepharoconjunctivitis, blepharokeratitis, and beyond. Due to significant overlap with other anterior segment conditions, infestation remains underdiagnosed and undertreated. Read More

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July 2018
10 Reads

Moraxella Keratitis: Analysis of Risk Factors, Clinical Characteristics, Management, and Treatment Outcomes.

Am J Ophthalmol 2019 Jan 8;197:17-22. Epub 2018 Sep 8.

University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

Purpose: To analyze the risk factors, clinical characteristics, management, and treatment outcomes of culture-proven cases of Moraxella keratitis at our center.

Design: Retrospective observational case series.

Methods: Thirty-nine culture-proven cases of Moraxella keratitis (39 eyes) diagnosed and treated between January 2003 and April 2018 at the University of Pittsburgh Medical Center were identified and retrospectively reviewed for ocular and systemic risk factors, treatment modalities, and outcomes, as well as for antimicrobial sensitivity and resistance data. Read More

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January 2019

High frequency of secondary, but not primary ocular manifestations of inflammatory bowel disease in patients treated at a tertiary care center.

Eur J Gastroenterol Hepatol 2018 12;30(12):1502-1506

Department of Ophthalmology, Martin Luther University Halle-Wittenberg, Halle, Germany.

Objective: Ocular manifestations of inflammatory bowel disease (IBD) are relevant complications of IBD. Only a few prospective studies are available on the characteristics of these manifestations. The aim of this study was to characterize the frequency of eye disease in patients with IBD, including primary and secondary ocular manifestations of IBD, and to identify patients who may need specialized ophthalmologic care. Read More

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December 2018
5 Reads

Prevalence and Load of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in Patients With Chronic Blepharitis in the Province of Erzincan, Turkey.

J Med Entomol 2018 Aug 17. Epub 2018 Aug 17.

Department of Ophthalmology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.

Chronic blepharitis is an ocular disease frequently encountered by ophthalmologists. Demodex mites can play a role in the pathogenesis of blepharitis along with bacterial agents, especially in treatment-resistant cases or recurrent cases after treatment. This study was performed to determine the prevalence and load of Demodex folliculorum (Simon) and Demodex brevis Akbulutova in chronic blepharitis patients and to assess the relationship between the prevalence and load of Demodex species and ocular symptoms. Read More

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August 2018
5 Reads

Safety and efficacy of 4-terpineol against microorganisms associated with blepharitis and common ocular diseases.

BMJ Open Ophthalmol 2018 4;3(1):e000094. Epub 2018 Jun 4.

Tissue Tech, Inc. R&D Dept. and Ocular Surface Center, Miami, Florida, USA.

Objective: Microbial infection has been reported to cause blepharitis, conjunctivitis and keratitis. We evaluated the safety and efficacy of a foam formulation of 2% 4-terpineol (T4O) against common ocular microorganisms.

Material And Methods: The antimicrobial effect of a 2% T4O formulation was evaluated by the United States Pharmacopeia 51 (USP <51>) antimicrobial effectiveness test for 14 and 28 days, as well as by a Time Kill Study (ASTM E2315) with a 60 s exposure time. Read More

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June 2018
1 Read

In vitro anti-demodectic effects and terpinen-4-ol content of commercial eyelid cleansers.

Cont Lens Anterior Eye 2018 Dec 14;41(6):513-517. Epub 2018 Aug 14.

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand. Electronic address:

Purpose: To compare the in vitro anti-demodectic activity of four commercially available dedicated eyelid cleansers (Cliradex towelette cleanser, Oust™ Demodex cleanser, Blephadex™ eyelid foam, TheraTears SteriLid eyelid cleanser), tea tree oil, undiluted terpinen-4-ol and linalool; and to assess the terpinen-4-ol content of the commercial cleansers and tea tree oil.

Methods: In vitro anti-demodectic efficacy assessment: 93 viable Demodex mites were acquired from the epilated eyelashes of 10 participants, and were randomised to application with one of the four eyelid cleansers, 100% and 50% tea tree oil, undiluted terpinen-4-ol and linalool, or no treatment. Following treatment application, mite viability was assessed for 300 min, based on limb/body movement and/or the development of a crenated/translucent appearance. Read More

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December 2018
6 Reads

Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia.

BMC Res Notes 2018 Aug 17;11(1):597. Epub 2018 Aug 17.

Department of Ophthalmology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Objectives: Empirical selections of antimicrobial therapy based on clinical observations are common clinical practices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility testing in northwest Ethiopia.

Results: Among 210 patients studied, conjunctivitis 32. Read More

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August 2018
1 Read

Quantitative Analysis of the Bacteria in Blepharitis With Demodex Infestation.

Front Microbiol 2018 31;9:1719. Epub 2018 Jul 31.

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, The Key Lab of Ophthalmology and Visual Science of Guangdong, Sun Yat-sen University, Guangzhou, China.

Bacterial infection or Demodex infestation has been reported to contribute to chronic blepharitis. The association between Demodex mites and bacterial flora in this disease remains to be elucidated. Fifty-six consecutive patients diagnosed with chronic blepharitis and 46 healthy volunteers were recruited for this study. Read More

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July 2018
7 Reads

Antimicrobial Activity of a New Aloe Vera Formulation for the Hygiene of the Periocular Area.

J Ocul Pharmacol Ther 2018 Oct 10;34(8):579-583. Epub 2018 Aug 10.

1 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa , Pisa, Italy .

Purpose: The aim of this study was to evaluate the antimicrobial activity of a novel preservative-free lid wipe formulation containing Aloe vera gel and hyaluronic acid that is commercialized for the hygiene of the periocular area.

Methods: In vitro susceptibility testing of the solution contained in wipes against bacteria and fungi commonly colonizing the periocular area, both reference strains and multidrug-resistant (MDR) clinical isolates, was assessed following the CLSI M07-A9 and M27-A3 broth methods, respectively. The solution was 2-fold serially diluted in broth from 25 μL (25% v/v) to 0. Read More

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October 2018
3 Reads

An eye for azithromycin: review of the literature.

Ther Adv Ophthalmol 2018 Jan-Dec;10:2515841418783622. Epub 2018 Jul 30.

Department of General Pharmacology, School of Medicine, University of Patras, Patras, Greece.

Azithromycin is used widely in clinical practice and recently it is available in topical solution for ophthalmic use. The purpose of the current publication is to summarize the newest information on azithromycin's clinical usefulness over ocular diseases. A PubMed (National Library of Medicine) and a ScienceDirect search was conducted using the key phrases 'azithromycin', 'meibomian', 'blepharitis', 'trachoma', 'toxoplasmosis' from 2010 to 2017. Read More

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July 2018
6 Reads

Occurrence and molecular composition of methicillin-resistant Staphylococcus aureus isolated from ocular surfaces of horses presented with ophthalmologic disease.

Vet Microbiol 2018 Aug 13;222:1-6. Epub 2018 Jun 13.

Institute of Microbiology and Epizootics, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Advanced Light and Electron Microscopy, Robert Koch Institute, Berlin, Germany. Electronic address:

Severe infections due to methicillin-resistant Staphylococcus aureus (MRSA) have been increasingly recognized in virtually all fields of veterinary medicine. Our objective was to study the occurrence, phylogenetic relationships and antimicrobial resistance properties of MRSA isolated from ocular surfaces of horses prior to invasive procedures. Within a 49-week sampling period, ocular swabs obtained from 46 eyes of 44 horses, including eyes with clinical signs of conjunctivitis/blepharitis, keratitis or uveitis were screened for the presence of S. Read More

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August 2018
3 Reads

Investigation of Demodex Parasite Existence in Treatment-Resistant Chronic Blepharitis Cases.

Turkiye Parazitol Derg 2018 Jun;42(2):130-133

İstanbul Medipol Üniversitesi, Göz Hastalıkları Anabilim Dalı, İstanbul, Türkiye.

Objective: Demodex acari is an obligate ectoparasite, and it is usually located in the human hair follicles, eyelash roots, and sebaceous glands. The aim of this study was to investigate the presence of Demodex infestation in chronic blepharitis cases that are resistant to therapy.

Methods: Patients who were admitted at the Istanbul Medipol University School of Medicine Hospital with a diagnosis of chronic blepharitis were included. Read More

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June 2018
1 Read

Relationship between blepharitis and components of the metabolic syndrome.

Arch Soc Esp Oftalmol 2018 Oct 19;93(10):476-480. Epub 2018 Jul 19.

Departamento de Bioquímica Aplicada, Facultad de Química, UNAM, Coyoacán, Ciudad de México, México. Electronic address:

Objective: To determine the relationship between the components of the metabolic syndrome with the presence of blepharitis.

Methods: The study included 60 patients with a diagnosis of blepharitis and 30 control subjects. Anthropometric measurements and blood pressure were recorded, and peripheral venous blood samples were obtained under fasting conditions to determine the concentration of Glucose, Cholesterol, and Triglycerides. Read More

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October 2018
2 Reads

Customary practices in the monitoring of dry eye disease in Sjogren's syndrome.

J Optom 2018 Oct - Dec;11(4):232-241. Epub 2018 Jul 17.

Centre for Contact Lens Research, School of Optometry& Vision Science University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada.

Purpose: Diagnostic testing for dry eye disease (DED) in Sjogren's syndrome (SS) is well described. Little is published about monitoring this systemic autoimmune DED. We analyzed the SS related DED tests used in North American optometric practices and compared academic settings to private practice settings. Read More

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October 2018
5 Reads

Evaluation of the Efficacy of Tea Tree Oil On the Density of Demodex Mites (Acari: Demodicidae) and Ocular Symptoms In Patients With Demodectic Blepharitis.

J Parasitol 2018 Oct 26;104(5):473-478. Epub 2018 Jul 26.

2   Health Services Vocational School, Erzincan University, 24100 Erzincan, Turkey.

The objective of this study was to examine the efficacy of 7.5% tea tree oil (TTO) eyelash shampoo on the density of Demodex (Acari: Demodicidae) and ocular symptoms in patients with demodectic blepharitis. A total of 135 patients diagnosed with demodectic blepharitis, following clinical inspection and parasitological examinations, were included in the study. Read More

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October 2018
22 Reads

Tiefe Trichophytie unter dem Bild einer Blepharitis - Tinea ciliaris.

J Dtsch Dermatol Ges 2018 Jul;16(7):911-912

Abteilung für Translationale Dermatoinfektiologie, Universitätsklinikum Münster.

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Simultaneous Subconjunctival Triamcinolone and Bevacizumab Injections for Management of Blepharokeratoconjunctivitis in Children.

Case Rep Ophthalmol Med 2018 5;2018:2602487. Epub 2018 Jun 5.

Department of Ophthalmology, Royal North Shore Hospital, Sydney, NSW, Australia.

Purpose: To report the efficacy of subconjunctival triamcinolone (Kenalog A-40, Alcon) and bevacizumab (Avastin, Genentech) injections in fraternal twins with blepharokeratoconjunctivitis (BKC) causing progressive, bilateral corneal neovascularization and scarring.

Methods: In this retrospective observational case series, two three-year-old male twins with BKC had presented with bilateral red eyes, photophobia, and frequent blinking. Examination of each child showed bilateral deep stromal and superficial corneal neovascularization, corneal infiltrates, multiple follicles on the palpebral conjunctiva bilaterally with blepharitis, and thick turbid sebum expressed from the Meibomian glands. Read More

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June 2018
1 Read

Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease.

J Virol 2018 09 16;92(17). Epub 2018 Aug 16.

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, USA

We previously isolated a herpes simplex virus 1 (HSV-1) mutant, KOS-NA, that carries two nonsynonymous mutations in , resulting in L393P and R950H amino acid substitutions in infected cell protein 6 (ICP6). Our published data studying KOS-NA pathogenesis strongly suggest that one of these ICP6 substitutions expressed from KOS-NA, R950H, severely impaired acute viral replication in the eyes and trigeminal ganglia of mice after inoculation onto the cornea and consequently impaired establishment and reactivation from latency. Because of its significant neuroattenuation, we tested KOS-NA as a potential prophylactic vaccine against HSV-1 in a mouse model of corneal infection. Read More

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September 2018
10 Reads

Chronic blepharitis.

Int J Dermatol 2018 Dec 26;57(12):1437-1438. Epub 2018 Jun 26.

Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.

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December 2018
2 Reads

Office-Based Diagnosis of Demodex Using Smartphone.

Eye Contact Lens 2018 Nov;44(6):e25-e26

Department of Ophthalmology, Diskapi Yildirim Beyazit Education and Training Hospital, University of Health Sciences, Ankara, Turkey.

Demodex is an important pathogen in ophthalmology. It is believed to cause a variety of eyelid and eyelash diseases. Currently, light microscopes are being used for imaging demodex. Read More

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November 2018

[A dog related Demodex spp. infestation in a student: a rare Demodex case].

Mikrobiyol Bul 2018 Apr;52(2):214-220

Selçuk University Faculty of Veterinary, Department of Parasitology, Konya, Turkey.

Demodicosis is an ectoparasitic cutaneous infestation of pilosebaceous unit caused by Demodex mites. Demodex spp. are considered to be pathogenic when they increase in number and infect dermis. Read More

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April 2018
21 Reads

Blepharitis caused by deep trichophytosis - tinea ciliaris.

J Dtsch Dermatol Ges 2018 Jul 21;16(7):911-912. Epub 2018 Jun 21.

Department of Translational Dermatoinfectiology, University Medical Center Münster, Münster, Germany.

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Ocular manifestations of psoriasis.

Arq Bras Oftalmol 2018 Jun;81(3):219-225

Dermatology Department, Universidade do Estado do Pará, Belém, PA, Brazil.

Purpose: We aimed to report the ocular manifestations observed in patients with psoriasis.

Methods: Patients were included and referred to our ophthalmology clinic from dermatology clinics of Universidade do Estado do Pará between October 2013 and August 2014. Clinical interviews were conducted to identify relevant epidemiological data, clinical features, and treatment details, and data were recorded using the same protocol. Read More

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June 2018
12 Reads

Antifungal drug ciclopirox olamine reduces HSV-1 replication and disease in mice.

Antiviral Res 2018 Aug 15;156:102-106. Epub 2018 Jun 15.

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S. Grand Blvd., St. Louis, Missouri, 63104, USA. Electronic address:

Herpes simplex virus (HSV)-1 and HSV-2 cause painful blisters and shallow ulcers in exposed skin and mucosae during primary or recurrent infection. In addition, recurrent and potentially blinding HSV-1 infections of the eye afflict nearly half a million persons in the U.S. Read More

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August 2018
2 Reads

The Ex vivo Eye Irritation Test (EVEIT) model as a mean of improving venom ophthalmia understanding.

Toxicon 2018 Aug 8;150:253-260. Epub 2018 Jun 8.

Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil. Electronic address:

Snakes belonging to the genus Naja (Elapid family), also known as "spitting cobras", can spit venom towards the eyes of the predator as a defensive strategy, causing painful and potentially blinding ocular envenoming. Venom ophthalmia is characterized by pain, hyperemia, blepharitis, blepharospasm and corneal erosions. Elapid venom ophthalmia is not well documented and no specific treatment exists. Read More

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August 2018
1 Read

Impact of blinking on ocular surface and tear film parameters.

Ocul Surf 2018 Oct 5;16(4):424-429. Epub 2018 Jun 5.

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand. Electronic address:

Purpose: To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology.

Methods: A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 77 did not. Blink rate, dry eye symptomology, tear film parameters, and ocular surface characteristics were assessed in a single clinical session. Read More

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October 2018
36 Reads

IL-1α and MMP-9 Tear Levels of Patients with Active Ocular Rosacea before and after Treatment with Systemic Azithromycin or Doxycycline.

Ophthalmic Res 2018 6;60(2):109-114. Epub 2018 Jun 6.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Multi-Centric Residency Program in Ophthalmology, Monterrey, Mexico.

Aims: The purpose of this paper was to determine the lacrimal concentration of IL-1α and MMP-9 in patients with active ocular rosacea before and after systemic treatment with azithromycin or doxycycline.

Methods: After 4 weeks of therapy with azithromycin (500 mg/day, 3 days a week PO) or doxycycline (200 mg/day PO), lacrimal samples were analyzed using an enzyme-linked immunosorbent assay multiplex.

Results: There was a significant difference between baseline IL-1α (37. Read More

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August 2018
1 Read

Eyelid tinea with blepharitis due to Microsporum canis.

Arch Soc Esp Oftalmol 2018 Oct 30;93(10):491-493. Epub 2018 May 30.

Servicio de Dermatología, Complejo Asistencial Universitario de Palencia, Palencia, España.

Case Report: The case is presented of a 3-year-old girl with an erythematous oedematous plaque associated with blepharitis, and chalazion in the right upper eyelid. She received empirical treatment with topical corticosteroids, as well as an antifungal and antibiotic, without observing any improvement. The culture of the eyelid scrape showed Microsporum canis. Read More

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October 2018
11 Reads

A Rare Case of Blebharitis: Phthiriasis Palpebrarum.

Turkiye Parazitol Derg 2018 Mar;42(1):90-92

Dünyagöz Hospital, Bursa, Turkey.

A six-year-old male patient was admitted to our hospital due to itching and scalding crusts that persisted 10-15 days in both eyes. Upon biomicroscopic examination, 5-6 semi-translucent, yellowish brown living lice attached to the upper eyelashes and a large number of eggs were observed. Following application of pilocarpine hydrochloride (Pilomann 2%, Bausch-Lomb) and topical proparacaine hydrochloride (Alcaine 0. Read More

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March 2018
2 Reads