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    1 OF 17

    Prevalence and associated factors of external punctal stenosis among elderly patients in Turkey.
    Arq Bras Oftalmol 2017 Sep-Oct;80(5):296-299
    Department of Ophthalmology, School of Medicine, Uludağ University, Bursa, Turkey.
    Purpose: To estimate the prevalence of external punctal stenosis (EPS) in the elderly population and investigate associated factors.

    Methods: A total of 278 patients ≥65 years of age were evaluated for evidence of EPS from January to July 2016. Associated systemic, ocular, demographic, and lifestyle factors were investigated. Read More

    Severe Corneal Disorders Developed After Brimonidine Tartrate Ophthalmic Solution Use.
    Cornea 2017 Dec;36(12):1567-1569
    *Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; †Department of Ophthalmology, Fukuchiyama City Hospital, Kyoto, Japan; ‡Oike-Ganka Ikeda Clinic, Kyoto, Japan; §Department of Ophthalmology, National Center for Geriatrics and Gerontology, Obu, Japan; and ¶Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Purpose: The primary side effects associated with 0.1% brimonidine tartrate (BT) ophthalmic solution with sodium chlorite are allergic conjunctivitis, blepharitis, and conjunctival hyperemia. However, cornea-related side effects are rare. Read More

    Tacrolimus Ointment for Refractory Posterior Blepharitis.
    Curr Eye Res 2017 Nov 18;42(11):1440-1444. Epub 2017 Sep 18.
    b Department of Ophthalmology , Santa Casa de Misericórdia de São Paulo , São Paulo , Brazil.
    Purpose: This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis.

    Methods: Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Read More

    Eyelid inflammation: An uncommon cause in occidental countries.
    Am J Emerg Med 2017 Nov 7;35(11):1789.e3-1789.e5. Epub 2017 Aug 7.
    Emergency Department, University Hospital of Bichat, AP-HP, Paris, France; Ilumens - Simulation laboratory, University of Paris-Diderot, Paris, France. Electronic address:
    Background: Myiasis designates the infestation of live human and vertebrate animals with dipterous (two-winged) larvae (maggots) and is the fourth most common travel-associated skin disease. Furuncle is the most common aspect of cutaneous myiasis.

    Case Presentation: A 24-year-old Caucasian female had been back from Cap-Vert. Read More

    Bacterial pathogens associated with external ocular infections alongside eminent proportion of multidrug resistant isolates at the University of Gondar Hospital, northwest Ethiopia.
    BMC Ophthalmol 2017 Aug 22;17(1):151. Epub 2017 Aug 22.
    Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences (CMHS), University of Gondar (UOG), P.O. box 196, Gondar, Ethiopia.
    Background: External ocular infection is a public health problem in Ethiopia. The aim of this study was to determine the prevalence and antimicrobial susceptibility pattern of external ocular bacterial infections.

    Methods: A cross sectional study was conducted at the University of Gondar Hospital among patients seeking health services at the Department of Ophthalmology from January to April, 2016. Read More

    Sebaceous gland carcinoma of the ocular adnexa - variability in clinical and histological appearance with analysis of immunohistochemical staining patterns.
    Graefes Arch Clin Exp Ophthalmol 2017 Nov 24;255(11):2277-2285. Epub 2017 Jul 24.
    Department of Ophthalmology, University Eye Hospital Bonn, University of Bonn, Ernst-Abbe Str. 2, 53127, Bonn, Germany.
    Purpose: The purpose of the study was to evaluate the characteristics of sebaceous gland carcinoma (SGC) of the ocular adnexae, which is due to a high variability in clinical, histological and immunohistochemical characteristics often challenging to diagnose.

    Methods: Records of six patients with SGC were reviewed, who underwent surgical excision and who were histologically diagnosed with SGC. For comparison, there were specimens from four patients with basal cell carcinoma (BCC) and four patients with squamous cell carcinoma (SCC). Read More

    One-year efficacy of adjunctive use of Ripasudil, a rho-kinase inhibitor, in patients with glaucoma inadequately controlled with maximum medical therapy.
    Graefes Arch Clin Exp Ophthalmol 2017 Oct 15;255(10):2009-2015. Epub 2017 Jul 15.
    Department of Ophthalmology and Micro-technology, Yokohama City University School of Medicine, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
    Purpose: The aim of this study was to evaluate the one-year efficacy, ability to lower intraocular pressure, and tolerability of ripasudil, a rho-kinase inhibitor, in patients with glaucoma inadequately controlled with maximum medical therapy.

    Methods: This prospective, non-comparative, interventional case-series study included 39 patients with primary open-angle glaucoma inadequately controlled with maximum medical therapy before treatment with ripasudil. Ripasudil was administered twice per day as adjunctive therapy to ongoing glaucoma treatment. Read More

    Retro-bulbar cyst of in Barbari goats.
    J Parasit Dis 2017 Jun 22;41(2):367-370. Epub 2016 Jun 22.
    College of Veterinary Sciences and Animal Husbandry, UP Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, 281001 India.
    Two adult Barbari goats were presented to the Division of Animal Health of the Institute with the history of unilateral protrusion of the left eye ball, blepharitis and congestion of the conjunctival membrane. Physical and ultrasonographical examination revealed large fluctuating fluid filled bladder with distinct dimensions. The cysts were successfully removed along with its membrane and parasitological examination revealed it as a , the intermediate stage of . Read More

    Ocular manifestation and their associated factors among HIV/AIDS patients receiving highly active antiretroviral therapy in Southern Ethiopia.
    Int J Ophthalmol 2017 18;10(5):776-781. Epub 2017 May 18.
    School of medicine, College of Medicine and Health Sciences, Hawassa University, Hawassa P.O.box 1560, Ethiopia.
    Aim: To assess the pattern of ocular manifestation and associated factors among human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients on highly active antiretroviral therapy (HAART) at Hawassa University Referral Hospital, Southern Ethiopia.

    Methods: A cross sectional study was conducted from January 2014 to April 2015. After obtaining informed written consent, 240 adult HIV/AIDS patients on HAART were randomly selected regardless of their ophthalmic symptoms, WHO status or CD4 count. Read More

    HIV-infected individuals on long-term antiretroviral therapy are at higher risk for ocular disease.
    Epidemiol Infect 2017 09 19;145(12):2520-2529. Epub 2017 May 19.
    Anova Health Institute,Johannesburg,South Africa.
    Introduction of antiretroviral therapy (ART) has dramatically reduced the incidence of infectious ocular diseases in human immunodeficiency virus (HIV)-infected individuals. However, the effects of long-term ART and chronic HIV infection on the eye are ill-defined. This study determined the occurrence and severity of ocular diseases among 342 participants in a rural South African setting: HIV-naïve (n = 105), HIV-infected ART-naïve (n = 16), HIV-infected on ART for 36 months (long-term ART; n = 165). Read More

    Risk factors for bleb-related infection following trabeculectomy surgery: ocular surface findings-a case-control study.
    Br J Ophthalmol 2017 07 18;101(7):868-873. Epub 2016 Oct 18.
    Department of Genetics, UCL Institute of Ophthalmology, London, UK.
    Purpose: Bleb-related infection (BRI) is a devastating complication of trabeculectomy surgery. The aim of this study was to identify ocular risk factors for BRI with specific emphasis on ocular surface parameters. It has been suggested that the frequency has increased since the introduction of antimetabolites, particularly mitomycin C. Read More

    Conjunctivochalasis and Related Factors in an Adult Population of Iran.
    Eye Contact Lens 2017 Mar 24. Epub 2017 Mar 24.
    Noor Ophthalmology Research Center (H.H.), Noor Eye Hospital, Tehran, Iran; Department of Epidemiology and Biostatics (H.R., A.F.), School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; and Center for Health Related Social and Behavioral Sciences Research (M.H.E.), Shahroud University of Medical Sciences, Shahroud, Iran.
    Objectives: To determine the prevalence of conjunctivochalasis and its determinants in a middle-aged Iranian population.

    Methods: This population-based study was conducted in the context of the second phase of Shahroud Eye Cohort Study in 2014. Of 4,737 participants aged 45 to 69 years who participated in the second phase, the data of 4,702 participants were available for this report. Read More

    Ocular bacterial infections at Quiha Ophthalmic Hospital, Northern Ethiopia: an evaluation according to the risk factors and the antimicrobial susceptibility of bacterial isolates.
    BMC Infect Dis 2017 03 14;17(1):207. Epub 2017 Mar 14.
    Department of Medical Microbiology and Immunology, Institute of Biomedical Sciences, College of Health Sciences, Mekelle University, 1871, Mekelle, Ethiopia.
    Background: External and intraocular infections can lead to visual impairments, which is a major public health problem. Bacteria are the most frequent pathogens affecting ocular structures; the increasing rate of antimicrobial drug resistance is a worldwide concern. The aim of this study was to determine the occurrence of bacteria in ocular infections, their antimicrobial susceptibility patterns, and risk factors in bacterial ocular infection. Read More

    Ten-year incidence and prevalence of clinically diagnosed blepharitis in South Korea: a nationwide population-based cohort study.
    Clin Exp Ophthalmol 2017 Jul 28;45(5):448-454. Epub 2017 Mar 28.
    Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
    Importance: Blepharitis is one of the most common conditions. However, no study has yet evaluated the epidemiology by evaluating a large population-based sample.

    Background: To evaluate the incidence and prevalence of clinically diagnosed blepharitis in South Korea. Read More

    [Alternative Methods of Local Therapy for Complicated Periocular Infections - Two Case Reports].
    Klin Monbl Augenheilkd 2017 Jan 30;234(1):36-39. Epub 2017 Jan 30.
    Augenklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz.
    Wounds of the eyelid can usually be cured with common surgical measures and the use of local antibiotics. Here we present two cases to demonstrate that biological debridement and negative pressure vacuum therapy (NPWT), two second line therapies, are effective and possibly superior alternatives to conventional, antibiotic-based approaches. A persistent infectious wound of the upper eyelid after surgical debridement of necrotising fasciitis and an upper eyelid abscess with multiple purulent entry points, which was refractory to a five-week antibiotic regimen, were treated with biological debridement and NPWT. Read More

    [Peri-ocular Necrotising Fasciitis - Case Report and Overview].
    Klin Monbl Augenheilkd 2017 Jan 30;234(1):40-45. Epub 2017 Jan 30.
    Augenklinik, Universitätsklinikum Düsseldorf.
    Peri-ocular necrotising fasciitis is a very rare ophthalmological clinical picture and is potentially fatal. This disease is caused by bacterial infection of the fasciae, which rapidly spreads. The present article reports a typical case of the disease and gives an overview of the typical clinical signs and symptoms of peri-ocular necrotising fasciitis. Read More

    [Ocular graft-versus-host disease: An often misdiagnosed etiology of dry eye syndrome].
    J Fr Ophtalmol 2017 Feb 18;40(2):122-125. Epub 2017 Jan 18.
    Service d'ophtalmologie II, centre hospitalier national des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.
    Purpose: To report a case of severe ocular graft-versus-host disease (GVHD) after cataract surgery.

    Methods: Observational case report.

    Results: We describe the case of a 59-year-old man with postoperative corneal ulcer on his only functional eye. Read More

    Demodex spp. Infestation Associated with Treatment-Resistant Chalazia and Folliculitis.
    Turkiye Parazitol Derg 2016 Dec;40(4):208-210
    Yıldırım Beyazıt Üniversitesi Yenimahalle Eğitim ve Araştırma Hastanesi, Tıbbi Mikrobiyoloji Kliniği, Ankara, Türkiye.
    Demodecidosis is an ectoparasitosis of pilosebaceous unit caused by demodex mites. The disease may be a primary skin disease or a secondary disease to inflammatory dermatoses such as folliculitis and rosacea. Demodex spp. Read More

    [Eye lid hygiene in chronic allergic blepharoconjunctivitis patients before laser refractive surgery].
    Vestn Oftalmol 2016;132(5):86-92
    Research Institute - Krasnodar Regional Hospital No. 1 named after Prof. S.V. Ochapovsky, 167 Pervogo Maya St., Krasnodar, Russian Federation, 350000.
    Aim: To evaluate the effectiveness of eyelid hygiene in patients with chronic allergic blepharoconjunctivitis (ABC) as a part of their preparation for laser refractive surgery.

    Material And Methods: The study involved 32 patients (12 males and 20 females aged 25-42 years) with refractive errors, namely, compound myopic astigmatism (23 patients) and hyperopic astigmatism (9 patients) suffering from chronic ABC and secondary dry eye syndrome (DES). All the patients initially received a standard treatment for ABC and DES, that is olopatodin hydrochloride instillations - 1 mg/ml 2 times daily, preservative-free hyaluronic acid preparation - 1 mg/ml 3 times daily, and polyacrylic acid and dexpanthenol gel at night for one month. Read More

    [Necrotising soft tissue infection of orbital area and hand: an unusual combination].
    Ned Tijdschr Geneeskd 2016 ;160(0):A9944
    Groene Hart Ziekenhuis, Gouda.
    Background: Necrotising soft tissue infection (NSTI) is an infection of the subcutaneous tissues and often follows a fulminant course if not recognised in time.

    Case Description: A 78-year-old man was brought to our emergency department in septic shock. Physical examination revealed an erythematous and painful swelling of the right eyelids and to a lesser extent of the right hand. Read More

    A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease.
    Ophthalmology 2017 01 3;124(1):43-52. Epub 2016 Nov 3.
    Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Australia. Electronic address:
    Purpose: To assess the efficacy of 2 forms of oral long-chain omega-3 (ω-3) essential fatty acid (EFA) supplements, phospholipid (krill oil) and triacylglyceride (fish oil), for treating dry eye disease (DED).

    Design: Randomized, double-masked, placebo-controlled clinical trial.

    Participants: This study was conducted at a single site and involved 60 participants with mild to moderate DED who were randomized (1:1:1) to 1 of 3 groups: placebo (olive oil), krill oil, or fish oil supplements. Read More

    Recurrent Fungal Keratitis and Blepharitis Caused by Aspergillus flavus.
    Am J Trop Med Hyg 2016 Nov 12;95(5):1216-1218. Epub 2016 Sep 12.
    Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.
    Aspergillus species produces a wide spectrum of fungal diseases like endophthalmitis and fungal keratitis ophthalmologically, but there has been no report about blepharitis caused by Aspergilus flavus to date. Herein, we report a 61-year-old ethnic Han Taiwanese male who had suffered from pain with burning and foreign body sensation after an insect bite on his left eye. Specimens from bilateral eyelids suggested infection of A. Read More

    Evaluation of Meibomian Gland Dysfunction in Polycystic Ovary Syndrome and Obesity.
    Curr Eye Res 2017 May 28;42(5):661-665. Epub 2016 Oct 28.
    c Department of Endocrinology , Bozyaka Education and Investigation Hospital, Izmir , Turkey.
    Purpose/Aim of the study: The purpose of this study was to evaluate the interaction between Polycystic ovary syndrome (PCOS) and Meibomian gland dysfunction (MGD) and obesity, to reveal whether there is a correlation between the testosterone levels and body-mass index (BMI) levels and the dry-eye complaints of these patients.

    Material And Methods: The study included 92 patients with PCOS and 52 healthy patients from March 2013 to March 2014. All patients underwent a physical examination, pelvic ultrasound, and clinical and biochemical tests, including free testosterone levels to confirm the diagnosis of PCOS. Read More

    Ice compresses aid the reduction of swelling and pain after scleral buckling surgery.
    J Clin Nurs 2016 Nov 22;25(21-22):3261-3265. Epub 2016 Aug 22.
    Department of Ophthalmology of The Second Xiangya Hospital, Central South University, Changsha, China.
    Aims And Objectives: To investigate the therapeutic effects of a local ice compress in alleviating eyelid swelling and errhysis and providing relief from pain after surgery.

    Background: Eyelid swelling and pain are the most common postoperative symptoms after scleral buckling surgery. A local ice compress can reduce the severity of swelling, errhysis and pain after acute injury as well as after surgery. Read More

    Functional and Morphologic Changes of Meibomian Glands in an Asymptomatic Adult Population.
    Invest Ophthalmol Vis Sci 2016 08;57(10):3996-4007
    Brien Holden Vision Institute University of New South Wales, Sydney, New South Wales, Australia 2Vision CRC, Sydney, New South Wales, Australia 3School of Optometry & Vision Science, University of New South Wales, Sydney, New South Wales, Australia.
    Purpose: The aim of the study was to understand natural changes of meibomian glands (MG) that occur with aging in the absence of any ocular pathology or ocular discomfort symptoms, to differentiate between "age normal" and pathologic or dysfunctional changes of the MG.

    Methods: A total of 185 subjects (109 females) with no pre-existing ocular and systemic abnormalities were recruited and divided into four age groups: 25 to 34, 35 to 44, 45 to 54, and 55 to 66 years. At a single visit, the following MG measures were collected: meibum quality (MQ) and MG expressibility (MGE) of the lower lid, and MG drop-out score (meiboscale) using infrared meibography of the upper and lower lids. Read More

    Ocular surface microbiome in meibomian gland dysfunction.
    Clin Exp Ophthalmol 2017 Mar 7;45(2):105-111. Epub 2016 Sep 7.
    Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand.
    Background: To investigate the ocular microbiome in meibomian gland dysfunction in Auckland, New Zealand.

    Design: Prospective, cross-sectional, observational, university-based study.

    Participants: Participants resident in New Zealand for ≥2 years (n = 157) were classified as normal (n = 66), mild (n = 41) or moderate-to-severe meibomian gland dysfunction (n = 50). Read More

    [Blepharitis - When to Perform Surgery?].
    Klin Monbl Augenheilkd 2016 Jul 28;233(7):813-8. Epub 2016 Jul 28.
    Universitäts-Augenklinik Bonn.
    Aim: Meibomian gland dysfunction/blepharitis is usually a harmless inflammatory process of the lid margin. However, it can be the first sign of a malignant lesion. Patients/Results: Clinical and histological findings are illustrated for 8 patients with changes in the lid margin and with the differential diagnosis of blepharitis. Read More

    Additive Intraocular Pressure Lowering Effects of the Rho Kinase Inhibitor, Ripasudil in Glaucoma Patients Not Able to Obtain Adequate Control After Other Maximal Tolerated Medical Therapy.
    Adv Ther 2016 Sep 20;33(9):1628-34. Epub 2016 Jul 20.
    Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa, 761-0793, Japan.
    Introduction: The aim of this study is to investigate the additive intraocular pressure (IOP)-lowering effects and safety of the selective Rho kinase inhibitor, 0.4% ripasudil, in patients with glaucoma not adequately controlled by other maximal tolerated medical therapies.

    Methods: We retrospectively reviewed 92 glaucoma patients who received ripasudil as an additive glaucoma treatment. Read More

    Psoriasis and Psoriatic Arthritis-Related Uveitis: Different Ophthalmological Manifestations and Ocular Inflammation Features.
    Semin Ophthalmol 2017 15;32(6):715-720. Epub 2016 Jul 15.
    a Department of Ophthalmology , Sapienza University of Rome , Rome , Italy.
    Purpose: To compare clinical features of uveitis in patients affected by psoriasis and psoriatic arthritis (PsA).

    Methods: A retrospective case-control study.

    Results: 117 patients were affected by uveitis and psoriasis or PsA (92 and 25 patients, respectively) from 2003 to 2013. Read More

    Etiology and Management of Allergic Eyelid Dermatitis.
    Ophthal Plast Reconstr Surg 2017 Jul/Aug;33(4):248-250
    Department of Ophthalmology and Visual Sciences, Washington University in St. Louis. St. Louis, Missouri, U.S.A.
    Purpose: Allergic dermatitis is a common but often misdiagnosed condition that can present with a variety of findings including inflammation, eyelid malposition, and tearing. This study was performed to identify likely etiologies, along with presenting findings and treatment strategies for allergic dermatitis.

    Methods: A retrospective review of clinical records was performed of patients diagnosed with allergic dermatitis in academic oculoplastics practices from 2002 to 2014. Read More

    Ocular Surface Disease in Breast Cancer Patients Using Aromatase Inhibitors.
    Breast J 2016 Sep 14;22(5):561-3. Epub 2016 Jun 14.
    1st Department of Ophthalmology, University of Athens, Athens, Greece.
    Aromatase inhibitors (AIs) are widely used as adjuvant hormonal therapy in postmenopausal women with hormone receptor-positive breast cancer. The purpose of this study was to investigate the potential impact of AIs on the anterior segment of the eye and especially the ocular surface. Participants in our study were 41 hormone receptor-positive early stage breast cancer patients (80 eyes), treated with AIs, while 80 eyes of 40 age- and gender-matched healthy controls, not previously used AIs for any purpose, were also evaluated. Read More

    The evaluation of meibomian gland function, morphology and related medical history in Asian adult blepharokeratoconjunctivitis patients.
    Acta Ophthalmol 2017 Sep 8;95(6):634-638. Epub 2016 Jun 8.
    Department of Ophthalmology and Vision Science, The Eye & ENT Hospital of Fudan University, Shanghai, China.
    Purpose: To evaluate the meibomian gland function, morphology and the related medical history of patients with blepharokeratoconjunctivitis (BKC) in comparison with healthy population and meibomian gland dysfunction (MGD)-induced evaporative dry eye (EDE) patients.

    Methods: Twenty-two eyes of 22 Asian adult patients with BKC were enrolled as the BKC group. Healthy volunteers and MGD-induced EDE patients were recruited in a 1:1 ratio and were matched in age, and the gender compositions of the three groups were also comparable. Read More

    Irregularly luscious lashes: difficult to say but a sinister sign to miss.
    BMJ Case Rep 2016 May 20;2016. Epub 2016 May 20.
    Russells Hall Hospital, Dudley, UK.
    We present a case of an 84-year-old man with advanced glaucoma on multiple unilateral glaucoma medication. He had 2 years history of unilateral ocular irritation thought to be related to his medication. Patient was referred to an oculoplastic clinic and found to have segmental eyelash loss partially masked by hypertrichosis caused by glaucoma medications. Read More

    BACTERIOLOGY AND RISK FACTORS OF BACTERIAL KERATITIS IN JIMMA, SOUTHWEST ETHIOPIA.
    Ethiop Med J 2015 Oct;53(4):191-7
    Background: In East Africa, particularly in Ethiopia, bacterial keratitis is a major cause of blindness.

    Objective: The aims of this study were to identify risk factors of bacterial keratitis and the spectrum of bacterial etiologies, and to assess the in-vitro antimicrobial susceptibility of these bacterial isolates at Jimma University Specialized Hospital, Southwest Ethiopia.

    Methods: A prospective study was employed from January 2012 to June 2012 from which a total of 24 patients with bacterial keratitis were included in the study. Read More

    Topical tacrolimus 0.03% for the treatment of ocular psoriasis.
    Arch Soc Esp Oftalmol 2016 Oct 26;91(10):505-7. Epub 2016 Apr 26.
    Departamento de Oftalmología, Hospital Universitario de Torrejón, Torrejón de Ardoz, Madrid, España.
    Objective/methods: Cases are presented of 4 patients suffering from severe symptoms due to ocular psoriasis and who were treated with off-label 0.03% tacrolimus once a day.

    Results/conclusions: All four patients had a mixed blepharitis and keratitis. Read More

    Development of Herpes Simplex Virus Infectious Epithelial Keratitis During Oral Acyclovir Therapy and Response to Topical Antivirals.
    Cornea 2016 May;35(5):692-5
    Department of Ophthalmology, New York University (NYU) School of Medicine, NYU Langone Medical Center, New York, NY.
    Purpose: To describe 3 cases of herpes simplex virus (HSV) vesicular blepharitis that progressed to infectious epithelial keratitis despite treatment with oral acyclovir, but responded to topical antiviral therapy.

    Methods: Retrospective review of a small case series.

    Results: One adult and 2 children presented with unilateral HSV vesicular blepharitis without evidence of corneal involvement. Read More

    [Clinical manifestations of 172 patients with blepharokeratoconjunctivitis].
    Zhonghua Yan Ke Za Zhi 2016 Mar;52(3):174-9
    Beijing Institute of Ophthalmology, Beijing Tongren Ophthalmic Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.
    Objective: To summarize the clinical characteristics, diagnosis, and treatment of blepharokeratoconjunctivitis (BKC).

    Methods: Retrospective analysis. One hundred and seventy-two patients were diagnosed as BKC between January 2012 and December 2014 at Beijing Tongren Hospital. Read More

    Over 25 Years of Clinical Experience With Ivermectin: An Overview of Safety for an Increasing Number of Indications.
    J Drugs Dermatol 2016 Mar;15(3):325-32
    Although the broad-spectrum anti-parasitic effects of the avermectin derivative ivermectin are well documented, its anti-inflammatory activity has only recently been demonstrated. For over 25 years, ivermectin has been used to treat parasitic infections in mammals, with a good safety profile that may be attributed to its high affinity to invertebrate neuronal ion channels and its inability to cross the blood-brain barrier in humans and other mammals. Numerous studies report low rates of adverse events, as an oral treatment for parasitic infections, scabies and head lice. Read More

    [A new classification for meibomian gland diseases with in vivo confocal microscopy].
    J Fr Ophtalmol 2016 Mar 16;39(3):239-47. Epub 2016 Feb 16.
    Service d'ophtalmologie III, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Centre d'investigations cliniques Inserm-DHOS CIC 1423, centre hospitalier national d'ophtalmologie des Quinze-Vingts, DHU vision et handicaps, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, université de Versailles Saint-Quentin-en-Yvelines, 75012 Versailles, France.
    Introduction: Meibomian gland dysfunction (MGD) is a frequent disorder often associated with dry eye disease. Slit-lamp examination with digital expression of the tarsal Meibomian glands allows examination of the contents of the distal Meibomian gland and the meatus. However, the Meibomian epithelium, interglandular space and proximal secretions cannot be clinically assessed. Read More

    Demodex treatment in external ocular disease: the outcomes of a Tasmanian case series.
    Int Ophthalmol 2016 Oct 2;36(5):691-6. Epub 2016 Feb 2.
    Tasmanian Eye Institute, 36 Thistle St West, South Launceston, TAS, 7249, Australia.
    Demodex species (spp.) have previously been implicated in the pathogenesis of blepharitis. This study aims to correlate improvement in symptoms of external ocular disease with treatment of underlying Demodex spp. Read More

    Ocular Findings of Myotonic Dystrophy Type 1 in the Korean Population.
    Graefes Arch Clin Exp Ophthalmol 2016 Jun 27;254(6):1189-93. Epub 2016 Jan 27.
    Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
    Purpose: To investigate ocular findings in a Korean population with myotonic dystrophy type 1 (DM1).

    Methods: A total of 24 Korean patients with DM1, ranging in age from 4 to 71 years, were examined over a period from June 2004 to May 2014. Ophthalmologic examinations including visual acuity assessment, slit-lamp biomicroscopy, ocular motility, cycloplegic refraction, and fundus examination were performed in all patients, and brain magnetic resonance (MR) imaging was performed in 15 patients. Read More

    The Effect of Demodex Infestation on Blepharitis and the Ocular Symptoms.
    Eye Contact Lens 2017 Jan;43(1):64-67
    Department of Ophthalmology (N.K., A.Ş.D., M.A., T.B., C.G.), Ministry of Health, Yildirim Beyazit Research and Education Hospital, Ankara, Turkey; and Department of Ophthalmology (E.U.K.), Dr. Sami Ulus Maternity and Children Research and Education Hospital, Ankara, Turkey.
    Objective: This study aimed to determine the frequency of Demodex infestation of eyelashes in patients with and without blepharitis and to determine the effects of Demodex infestation on blepharitis and the ocular symptoms.

    Methods: The study included patients with chronic mixed (anterior + posterior) blepharitis who presented to our clinic. Patients with refractive error and no ocular disease were enrolled as the control group. Read More

    Syndrome in question.
    An Bras Dermatol 2015 Nov-Dec;90(6):909-11
    Faculdade Evangélica do Paraná, Curitiba, PR, Brazil.
    Morbihan Syndrome is a rare entity with unknown etiology. It is clinically characterized by chronic erythematous edema on the face - especially in the middle and upper third of the face - and creates abnormal facial contours that are initially intermitent but become permanent with the development of the syndrome. The histopathology is nonspecific and its therapy is a major challenge due to poor response to the various treatment options. Read More

    Morphological and Functional Evaluation of Meibomian Gland Dysfunction in Rosacea Patients.
    Curr Eye Res 2016 Aug 7;41(8):1029-1034. Epub 2015 Dec 7.
    f Department of General Pathology , Pomeranian Medical University , Szczecin , Poland.
    Purpose: Skin rosacea is a chronic inflammatory disease affecting up to 10% of the population in some European countries. Although considered a skin disease, acne rosacea may involve the eyes, causing eyelid and ocular surface inflammation. This study investigated the relationship between skin rosacea and various signs of ocular involvement and evaluated severity of meibomian gland dysfunction in rosacea patients. Read More

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