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Rom J Ophthalmol 2022 Jan-Mar;66(1):41-48

Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

To study the long-term outcomes of lacrimal canalicular trephination (LCT) with viscoelastic-assisted monocanalicular stenting (VAMS) for the treatment of epiphora secondary to lacrimal canalicular obstructions (LCO). Our study was a retrospective interventional work. All patients diagnosed with LCO, having morbid epiphora (Munk's scale ≥ 2), were included. Read More

Indian J Ophthalmol 2022 Apr;70(4):1327-1330

Department of Vitreo-Retina, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

Purpose: To study the clinical presentations and outcomes of phthiriasis palpebrarum (PP) managed with combined treatment modality comprising of 20% fluorescein dye, mechanical removal of the ectoparasites, and topical application of antibiotic eye ointment with paraffin base.

Methods: This is a prospective interventional noncomparative hospital-based series of 13 patients of PP. All the patients underwent local application of 20% fluorescein dye over the eyelashes and eyebrows of both the eyes followed by the mechanical removal of all the ectoparasites and trimming of the eyelashes from the base followed by application of ophthalmic ointment. Read More

Cornea 2022 Jun 4;41(6):699-708. Epub 2022 Mar 4.

Centre for Vision and Eye Research, School of Optometry and Vision Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, Australia.

Purpose: Although meibography provides direct evidence of gland dropout in meibomian gland dysfunction, this specialized technique is not available in most clinics. The primary aim was to determine which clinical ocular marker was most related to meibomian area loss. A secondary aim was to determine associations with confocal microscopy imaging of the lid margin. Read More

Sci Rep 2021 12 21;11(1):24296. Epub 2021 Dec 21.

Department of General Biology and Parasitology, Medical University of Warsaw, 02-004, Warsaw, Poland.

The aim of the study was to analyze the correlation between the presence of Demodex mites in the hair follicles of patients' eyelashes and the stability and break up time of the tear film assessed with the Non-Invasive Tear Break Up Times (NIBUT) method. 319 patients were included in the study (195 women, 124 men). The patients were divided into two groups: those with Demodex infestation and without visible symptoms of eyelid or eye surface diseases, and asymptomatic non-infested patients. Read More

J Cataract Refract Surg 2021 Dec;47(12):1599

Rio de Janeiro, Brazil.

A 21-year-old man was referred for refractive surgery evaluation. Spectacle dependence and poor visual quality in his left eye is his chief complaint. He cannot tolerate contact lenses (CLs). Read More

Indian J Ophthalmol 2021 Dec;69(12):3482-3486

Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To describe the clinical profile and demographic distribution of Terrien's marginal degeneration (TMD) in patients presenting to a multitier ophthalmology hospital network in India.

Methods: This cross-sectional hospital-based study included 2,470,793 new patients presenting between September 2012 and September 2020 (~8 years period). Patients with a clinical diagnosis of TMD in at least one eye were included as cases. Read More

J Eur Acad Dermatol Venereol 2022 Apr 15;36(4):592-601. Epub 2021 Dec 15.

Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Ocular surface diseases (OSDs), including conjunctivitis and blepharitis, are common in atopic dermatitis (AD) patients, but the magnitude and patient characteristics are unclear.

Objectives: To examine the prevalence of OSDs in adults with AD and identify patient characteristics and risk factors.

Methods: We designed a cross-sectional questionnaire-based survey and sent it via a secure public mail to all adult Danes with a hospital diagnosis of AD (ICD-10 code L20. Read More

Sci Rep 2021 11 22;11(1):22680. Epub 2021 Nov 22.

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan, ROC.

Whether patients with Mycoplasma infection have an increased risk of ocular surface ulcers. Using a nation-wide database, we identified patients with a new diagnosis of Mycoplasma infection between 1997 and 2013, and compared them with age-, sex-, and index year-matched subjects without the infection. Cox proportional regression was performed to compare the risk of corneal diseases between the two cohorts. Read More

J Oncol Pharm Pract 2022 Apr 13;28(3):725-728. Epub 2021 Nov 13.

University of Health Sciences, 146992Diskapi Yildirim Beyazit Training and Research Hospital, Department of Hematology, Ankara, Turkey.

Introduction: Imatinib is generally well tolerated by patients. The most common ophthalmic side effects are eyelid edema and periorbital edema. Other side effects which occur at rates of <1% include blepharitis, blurred vision, conjunctival hemorrhage, conjunctivitis, retinal hemorrhage, etc. Read More

Sci Rep 2021 11 1;11(1):21398. Epub 2021 Nov 1.

HanGil Eye Hospital, 35, Bupyeong-daero, Bupyeong-gu, Incheon, 21388, South Korea.

Our study evaluated the association between Demodex infestation and recurrent hordeola and examined the clinical features associated with these eyelid lesions. This was an observational, comparative study. We reviewed 250 patients and divided them into the recurrent hordeolum (n = 153) and control (n = 97) groups. Read More

Cornea 2022 Apr;41(4):417-426

Sight Sciences, Inc, Menlo Park, CA.

Purpose: The aim of this study was to demonstrate the safety and effectiveness of a single TearCare procedure compared with a single LipiFlow procedure in treatment of the dry eye disease associated with meibomian gland dysfunction.

Methods: In a multicenter, masked, randomized controlled trial, 135 subjects received a single TearCare (TC) treatment (n = 67) or a single LipiFlow (LF) treatment (n = 68) at baseline and were followed up for 1 month posttreatment. Tear film breakup time, meibomian gland function, and corneal and conjunctival staining scores were assessed as dry eye signs at baseline, 2 weeks, and 1 month; dry eye symptoms were assessed using the Ocular Surface Disease Index, Symptom Assessment in Dry Eye, and eye dryness questionnaires at baseline and 1 month. Read More

Orv Hetil 2021 09 19;162(38):1533-1540. Epub 2021 Sep 19.

1 Semmelweis Egyetem, Általános Orvostudományi Kar, Szemészeti Klinika, Budapest, Mária u. 39., 1085.

Összefoglaló. Célkitűzés: A monoklonális gammopathia szemészeti jeleinek és szövődményeinek vizsgálata. Betegek és módszerek: Két nagy budapesti hematológiai ellátóhely 1999 és 2020 között diagnosztizált és/vagy kezelt, monoklonális gammopathiát mutató betegeit vizsgáltuk (42 beteg 84 szeme, 42,86% férfi; átlagéletkor 63,83 ± 10,76 év). Read More

J Ocul Pharmacol Ther 2021 10 20;37(8):479-484. Epub 2021 Aug 20.

Asociación para Evitar la Ceguera en Mexico I.A.P., Mexico City, Mexico.

To evaluate the efficacy of topical lotilaner ophthalmic solution, 0.25%, in patients with blepharitis. Eighteen adults with blepharitis, defined as >10 collarettes on the upper lid and/or mite density of ≥1. Read More

Cornea 2022 Apr;41(4):427-434

Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea.

Purpose: The purpose of this study was to evaluate the efficacy of topical ivermectin 1% cream application on the eyelashes in combination with eyelid hygiene in the treatment of Demodex blepharitis.

Methods: One hundred two eyes of 102 patients with symptomatic Demodex blepharitis were divided into 2 groups according to the use of topical ivermectin in this retrospective case-control study. The ivermectin group (n = 51) applied topical ivermectin 1% cream on the eyelashes for 15 minutes once weekly, but the control group (n = 51) did not. Read More

Clin Exp Optom 2022 May 17;105(4):385-391. Epub 2021 Jun 17.

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.

Clinical Relevance: Conjunctivitis, chalazion and blepharitis are routinely managed by optometrists. However, it is especially important to consider the diagnosis of canaliculitis in patients with chronic or recurrent conditions.

Background: This study aimed to report the clinical features, radiological findings and treatment outcomes in patients with plug-related canaliculitis. Read More

Cochrane Database Syst Rev 2021 06 9;6:CD013697. Epub 2021 Jun 9.

Byers Eye Institute, Stanford University, Palo Alto, California, USA.

Background: Posterior blepharitis is common and causes ocular surface and lid damage as well as discomfort. It affects 37% to 47% of all ophthalmology patients; its incidence increasing with age. It is a multifactorial disease associated with multiple other pathologies, such as rosacea, meibomianitis, and infections. Read More

Cornea 2021 Oct;40(10):1363-1364

Department of Ophthalmology, Prince of Wales Hospital, Sydney, Australia; and.

Purpose: The purpose of this study is to report a case of corneal epithelial defects resulting from topical treatment of blepharitis with tea tree oil (TTO).

Methods: A 44-year-old man with a 1 year history of blepharitis non-responsive to eyelid hygiene was found to have signs of Demodex infestation. He was treated with a topical, off-label 50% TTO solution. Read More

Adv Ther 2021 07 24;38(7):3760-3770. Epub 2021 May 24.

Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo Hospital, The University of Tokyo, Tokyo, Japan.

Introduction: We aimed to evaluate the additional effects and safety of a Rho-associated protein kinase (ROCK) inhibitor, ripasudil hydrochloride hydrate, in Japanese patients with primary open-angle glaucoma (POAG) with an intraocular pressure (IOP) of at most 15 mmHg undergoing prostaglandin F (FP) receptor agonist monotherapy (FP monotherapy).

Methods: In this prospective observational study, 30 Japanese patients with POAG and IOP of at most 15 mmHg (mean age 59.4 years; 10 men) who were undergoing FP monotherapy in both eyes were administered an additional dose of ripasudil hydrochloride hydrate (GLANATEC ophthalmic solution 0. Read More

Cont Lens Anterior Eye 2021 12 7;44(6):101453. Epub 2021 May 7.

Grupo de Investigación Biomedicina, Faculty of Medicine, Fundacion Universitaria Autonoma de las Americas, Pereira, Risaralda, Colombia.

Purpose: A systematic review and meta-analysis was performed to evaluate the effectiveness of interventions in the treatment ofDemodex blepharitis in adult patients.

Methods: A systematic review and meta-analysis of studies reporting the efficacy of treatments forDemodex blepharitis in the main databases (PubMed / Scopus / Cochrane / EMBASE / Science Direct / WOS / Scielo / Google Scholar / metaRegister of Controlled Trials / ClinicalTrials.gov/ WHO ICTRP) until November 24, 2020 was performed according to the PRISMA statement for meta-analysis. Read More

J Oleo Sci 2021 Jun 21;70(6):799-805. Epub 2021 May 21.

Department of Ophthalmology, Keio University School of Medicine.

Introduction: Demodex mites are microscopic arthropods that have been shown to be responsible for chronic blepharitis. Although many reports have demonstrated positive effects of lid hygiene on demodicosis, some have produced conflicting results. We retrospectively evaluated the effect of lid margin cleansing with a novel lid hygiene detergent, Eye Shampoo, in patients with ocular demodicosis. Read More

Turk J Ophthalmol 2021 04;51(2):89-94

Yakın Doğu University Faculty of Medicine, Department of Ophthalmology, Nicosia, Cyprus

Objectives: We aimed to evaluate the efficacy of periocular intense pulsed light (IPL) therapy in the treatment of moderate to severe acute blepharitis or blepharoconjunctivitis.

Materials And Methods: This was a retrospective study performed in one institution. Eleven patients who received bilateral periocular IPL therapy using an IPL device (E>Eye, ESwin, Paris, France) were retrospectively evaluated. Read More

Eur J Ophthalmol 2021 Apr 8:11206721211008780. Epub 2021 Apr 8.

First Department of Ophthalmology, G. Gennimatas General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Introduction: Cystic fibrosis (CF) is the most common life-shortening recessive genetic disease in Caucasians, affecting primarily the lungs. The objective of our study was to investigate potential ophthalmologic involvement in adult patients with CF.

Methods: Fifty adult patients with cystic fibrosis and 60 age- and sex-matched controls underwent complete ophthalmologic examination including tear-film Break-Up Time (BUT), Macular Thickness, and peripapillary Retinal Nerve Fiber Layer (pRNFL) thickness measurements using Spectral Domain-OCT. Read More

Int Ophthalmol 2021 Aug 8;41(8):2765-2775. Epub 2021 Apr 8.

Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), 176001, Himachal Pradesh, India.

Aim: To study frequency and characteristics of ocular manifestations in Indian patients with collagen vascular disorders.

Methods: The medical records of 73 patients (Males: Females 16:57) aged between 22 and 78 years (mean ± SD = 43.5 ± 12. Read More

J Cosmet Dermatol 2021 Jun 16;20(6):1846-1848. Epub 2021 Apr 16.

Division of Ophthalmic Plastic and Reconstructive Surgery, University of Health Sciences, Haydarpasa Numune Education and Research Hospital, Sadik Eratik Eye Institute, Istanbul, Turkey.

Background: The increased popularity of periocular cosmetic applications in recent years has resulted in the appearance of various complications. The cosmetic eyelash lifting is one of these new techniques and is gradually becoming more popular. There are no previous reports of any complications of this procedure in the literature. Read More

Clin Exp Dermatol 2021 Aug 2;46(6):1119-1120. Epub 2021 May 2.

Department of Dermatology, Kagawa University Faculty of Medicine, Kagawa, Japan.

Am J Ophthalmol 2021 07 15;227:139-142. Epub 2021 Mar 15.

From the Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel (H.H., E.A., A.Y., D.B., M.Z., R.P.D.-G.); Department of Dermatology, Emek Medical Center, Afula, Israel (H.H., A.Y., M.Z., R.P.D.-G.); Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada (R.P.D.-G.).. Electronic address:

Purpose: To assess the prevalence of ophthalmic findings in patients with Darier disease, an autosomal dominant genetic skin disorder, in an effort to evaluate the need for eye examinations in the management of the disease.

Design: Prospective observational case series.

Methods: Thirty-six individuals with Darier disease were evaluated by both ocular assessment questionnaire and a comprehensive ophthalmic examination (visual acuity, refraction, external examination, and slit-lamp examination) with emphasis on the eyelids, conjunctiva, and cornea. Read More

Semin Ophthalmol 2021 Nov 10;36(8):719-722. Epub 2021 Mar 10.

Department of Ophthalmology, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey.

Purpose: To investigate in vitro effects of active ingredients in eye cleansing wipes and solutions on the life span of Demodex.

Methods: Demodex mites were extracted by eyelash epilation method from volunteers who were found to have chronic demodex blepharitis during an ophthalmological examination. Preparations with three or more motile, live adult Demodex parasites were included in the study. Read More

Turkiye Parazitol Derg 2021 03;45(1):80-82

Balıkesir Devlet Hastanesi, Tıbbi Mikrobiyoloji Laboratuvarı, Balıkesir, Türkiye

Phthiriasis palpebrarum is a rare eyelid infestation caused by (pubic lice) that is often confused with other causes of blepharoconjunctivitis. In this study, we report the case of a 49-year-old male patient with phthiriasis palpebrarum who presented with itching and eye irritation in the left eye and had undergone treatment for conjunctivitis in the past month. Biomicroscopic examination revealed a dense population of motile and translucent lice and eggs, more intensely on the upper lid. Read More

BMC Ophthalmol 2021 Mar 6;21(1):122. Epub 2021 Mar 6.

Department of Medical Oncology, Tongde hospital of Zhejiang Province, NO, 234, Gucui Road, Hangzhou, 310012, Zhejiang, China.

Background: Phthirus pubis is an obligate parasite of human beings. Demodex spp. is a much more common parasite of human beings. Read More

Cont Lens Anterior Eye 2021 12 23;44(6):101429. Epub 2021 Feb 23.

Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Purpose: To determine the age and sex-standardized prevalence and risk factors of anterior blepharitis in a geriatric population in "…".

Methods: This population-based study was conducted on the elderly population (over 60 years of age) of Tehran, the capital of "…" in 2019. Examinations included visual acuity assessment, refraction, and complete slit lamp examination. Read More