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    Functional and Morphologic Changes of Meibomian Glands in an Asymptomatic Adult Population.
    Invest Ophthalmol Vis Sci 2016 Aug;57(10):3996-4007
    Brien Holden Vision Institute University of New South Wales, Sydney, New South Wales, Australia 2Vision CRC, Sydney, New South Wales, Australia 3School of Optometry & Vision Science, University of New South Wales, Sydney, New South Wales, Australia.
    Purpose: The aim of the study was to understand natural changes of meibomian glands (MG) that occur with aging in the absence of any ocular pathology or ocular discomfort symptoms, to differentiate between "age normal" and pathologic or dysfunctional changes of the MG.

    Methods: A total of 185 subjects (109 females) with no pre-existing ocular and systemic abnormalities were recruited and divided into four age groups: 25 to 34, 35 to 44, 45 to 54, and 55 to 66 years. At a single visit, the following MG measures were collected: meibum quality (MQ) and MG expressibility (MGE) of the lower lid, and MG drop-out score (meiboscale) using infrared meibography of the upper and lower lids. Read More

    Irregularly luscious lashes: difficult to say but a sinister sign to miss.
    BMJ Case Rep 2016 May 20;2016. Epub 2016 May 20.
    Russells Hall Hospital, Dudley, UK.
    We present a case of an 84-year-old man with advanced glaucoma on multiple unilateral glaucoma medication. He had 2 years history of unilateral ocular irritation thought to be related to his medication. Patient was referred to an oculoplastic clinic and found to have segmental eyelash loss partially masked by hypertrichosis caused by glaucoma medications. Read More

    BACTERIOLOGY AND RISK FACTORS OF BACTERIAL KERATITIS IN JIMMA, SOUTHWEST ETHIOPIA.
    Ethiop Med J 2015 Oct;53(4):191-7
    Background: In East Africa, particularly in Ethiopia, bacterial keratitis is a major cause of blindness.

    Objective: The aims of this study were to identify risk factors of bacterial keratitis and the spectrum of bacterial etiologies, and to assess the in-vitro antimicrobial susceptibility of these bacterial isolates at Jimma University Specialized Hospital, Southwest Ethiopia.

    Methods: A prospective study was employed from January 2012 to June 2012 from which a total of 24 patients with bacterial keratitis were included in the study. Read More

    Development of Herpes Simplex Virus Infectious Epithelial Keratitis During Oral Acyclovir Therapy and Response to Topical Antivirals.
    Cornea 2016 May;35(5):692-5
    Department of Ophthalmology, New York University (NYU) School of Medicine, NYU Langone Medical Center, New York, NY.
    Purpose: To describe 3 cases of herpes simplex virus (HSV) vesicular blepharitis that progressed to infectious epithelial keratitis despite treatment with oral acyclovir, but responded to topical antiviral therapy.

    Methods: Retrospective review of a small case series.

    Results: One adult and 2 children presented with unilateral HSV vesicular blepharitis without evidence of corneal involvement. Read More

    [Clinical manifestations of 172 patients with blepharokeratoconjunctivitis].
    Zhonghua Yan Ke Za Zhi 2016 Mar;52(3):174-9
    Beijing Institute of Ophthalmology, Beijing Tongren Ophthalmic Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.
    Objective: To summarize the clinical characteristics, diagnosis, and treatment of blepharokeratoconjunctivitis (BKC).

    Methods: Retrospective analysis. One hundred and seventy-two patients were diagnosed as BKC between January 2012 and December 2014 at Beijing Tongren Hospital. Read More

    Over 25 Years of Clinical Experience With Ivermectin: An Overview of Safety for an Increasing Number of Indications.
    J Drugs Dermatol 2016 Mar;15(3):325-32
    Although the broad-spectrum anti-parasitic effects of the avermectin derivative ivermectin are well documented, its anti-inflammatory activity has only recently been demonstrated. For over 25 years, ivermectin has been used to treat parasitic infections in mammals, with a good safety profile that may be attributed to its high affinity to invertebrate neuronal ion channels and its inability to cross the blood-brain barrier in humans and other mammals. Numerous studies report low rates of adverse events, as an oral treatment for parasitic infections, scabies and head lice. Read More

    [A new classification for meibomian gland diseases with in vivo confocal microscopy].
    J Fr Ophtalmol 2016 Mar 16;39(3):239-47. Epub 2016 Feb 16.
    Service d'ophtalmologie III, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Centre d'investigations cliniques Inserm-DHOS CIC 1423, centre hospitalier national d'ophtalmologie des Quinze-Vingts, DHU vision et handicaps, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, université de Versailles Saint-Quentin-en-Yvelines, 75012 Versailles, France.
    Introduction: Meibomian gland dysfunction (MGD) is a frequent disorder often associated with dry eye disease. Slit-lamp examination with digital expression of the tarsal Meibomian glands allows examination of the contents of the distal Meibomian gland and the meatus. However, the Meibomian epithelium, interglandular space and proximal secretions cannot be clinically assessed. Read More

    Syndrome in question.
    An Bras Dermatol 2015 Nov-Dec;90(6):909-11
    Faculdade Evangélica do Paraná, Curitiba, PR, Brazil.
    Morbihan Syndrome is a rare entity with unknown etiology. It is clinically characterized by chronic erythematous edema on the face - especially in the middle and upper third of the face - and creates abnormal facial contours that are initially intermitent but become permanent with the development of the syndrome. The histopathology is nonspecific and its therapy is a major challenge due to poor response to the various treatment options. Read More

    Long-term Natural History of Dry Eye Disease from the Patient's Perspective.
    Ophthalmology 2016 Feb 21;123(2):425-33. Epub 2015 Nov 21.
    Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Division of Preventive Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology & Visual Sciences, Center for Translational Medicine, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah. Electronic address:
    Purpose: To describe the natural history of dry eye disease (DED), which chronically affects millions of people in the United States.

    Design: This study is based on the Women's Health Study and Physicians' Health Studies, and uses questionnaires and medical records.

    Participants: A total of 398 men and 386 women who reported a diagnosis of DED and responded to a questionnaire about change in disease since diagnosis. Read More

    [Lipoid proteinosis (Urbach-Wiethe's Disease)].
    Kulak Burun Bogaz Ihtis Derg 2015 ;25(6):357-60
    Department of Pathology, Kayseri Training and Research Hospital, 38010 Kocasinan, Kayseri, Turkey.
    A 25-year-old female patient was admitted to our outpatient clinic with postpartum hoarseness. Punch biopsy specimens obtained from the larynx and sublingual region revealed multi-folded squamous epithelium with a hyperkeratosis pattern and amorphous hyaline material aggregation. This aggregation was also remarkable around the vessels. Read More

    Primary cutaneous extranodal marginal zone B-cell lymphoma of the eyelid skin: Diagnostic clues and distinction from other ocular adnexal diseases.
    Surv Ophthalmol 2016 May-Jun;61(3):333-8. Epub 2015 Nov 3.
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Ophthalmic Plastic Surgery, Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, USA.
    A 60-year-old man developed a rubbery thickening and erythema of his left lateral upper and lower eyelids and lateral canthus over several months. He was treated for an extended period of time for blepharitis and chalazia. Incisional biopsy eventually disclosed microscopically a hypercellular lymphoid population sparing the epidermis that surrounded adnexal structures and infiltrated between orbicularis muscle fibers. Read More

    Pyoblepharitis Vegetans in Association With Pyodermatitis-Pyostomatitis Vegetans: Expanding the Spectrum of a Rare, Multisystem Disorder.
    J Cutan Med Surg 2016 Mar-Apr;20(2):163-5. Epub 2015 Oct 30.
    Division of Dermatology, University of Calgary, Calgary, Alberta, Canada
    Background: Pyodermatitis-pyostomatitis vegetans (PDPSV) is a rare inflammatory disorder of the skin and oral mucosa that is commonly associated with inflammatory bowel disease (IBD). Ocular involvement is uncommon.

    Objective: Given the association with IBD, it is important for dermatologists to be aware of the varying manifestations of PDPSV. Read More

    Granulomatous nephritis and dermatitis in a patient with BRAF V600E mutant metastatic melanoma treated with dabrafenib and trametinib.
    Melanoma Res 2015 Dec;25(6):550-4
    Departments of aMedical Oncology bNephrology cPathology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
    A 61-year-old man was diagnosed with stage IIIB BRAF V600E mutant melanoma in October 2012. He was treated with a combination therapy of dabrafenib and trametinib. He remained in complete remission for 18 months and the treatment was well tolerated after dose reduction because of pyrexia. Read More

    Common Blepharitis Related to Phthiriasis Palpebrarum: Argon Laser Phototherapy.
    Turkiye Parazitol Derg 2015 Sep;39(3):252-4
    Department of Ophthalmology, Mersin University, Mersin, Turkey.
    A 42-year-old woman was admitted to Mersin University, Department of Ophthalmology Clinic with itching and burning sensation of the right eye for 3 weeks. In her slit-lamp examination, nits and lice, attached to the upper and lower eyelashes of her right eye, were observed. Lice and nits were destroyed by argon laser phototherapy and were removed with the help of a fine forceps thereafter. Read More

    One-year clinical evaluation of 0.4% ripasudil (K-115) in patients with open-angle glaucoma and ocular hypertension.
    Acta Ophthalmol 2016 Feb 4;94(1):e26-34. Epub 2015 Sep 4.
    Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan.
    Purpose: To investigate the intra-ocular pressure (IOP)-lowering effects and safety of 0.4% ripasudil (K-115), a Rho kinase inhibitor, twice daily for 52 weeks, in patients with open-angle glaucoma or ocular hypertension (OHT).

    Methods: In this multicentre, prospective, open-label study, 388 patients with primary open-angle glaucoma, OHT or exfoliation glaucoma were enrolled and 354 of them were subdivided into four cohorts (monotherapy, 173; additive therapy to prostaglandin analogs, 62; β-blockers, 60; or fixed combination drugs, 59). Read More

    Detection of Acanthamoeba on the ocular surface in a Spanish population using the Schirmer strip test: pathogenic potential, molecular classification and evaluation of the sensitivity to chlorhexidine and voriconazole of the isolated Acanthamoeba strains.
    J Med Microbiol 2015 Aug;64(8):849-53
    1​University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Avda Astrofísico Fco. Sánchez, S/N, 38203 La Laguna, Tenerife, Canary Islands, Spain.
    Pathogenic strains of Acanthamoeba are causative agents of a sight-threatening infection of the cornea known as Acanthamoeba keratitis, which is often associated with the misuse of contact lenses. However, there is still a question remaining to be answered, which is whether these micro-organisms are present on the ocular surface of healthy individuals. Therefore, the aim of this study was to determine the presence of Acanthamoeba on the ocular surface in healthy patients and also in those with other ocular surface infections. Read More

    Periodic acid-Schiff staining demonstrates fungi in chronic anterior blepharitis.
    Eye (Lond) 2015 Dec 21;29(12):1522-7. Epub 2015 Aug 21.
    Department of Ophthalmology, Mevlana University School of Medicine, Konya, Turkey.
    Purpose: To evaluate the presence of fungi in patients with chronic anterior blepharitis with periodic acid-Schiff (PAS) staining of the eyelashes in addition to the conventional methods of fungal cultures and direct microscopy.

    Methods: Nineteen patients with chronic anterior blepharitis of seborrheic or mixed seborrheic/staphylococcal type and 11 healthy age- and sex-matched controls were included in this prospective, nonrandomized, cross-sectional study. Blepharitis was diagnosed based on clinical evidence of greasy scales between the cilia, lid margin erythema, conjunctival hyperemia, telangiectasia, thickening, or irregularity of the eyelid margins by slit-lamp biomicroscopy. Read More

    Demodex sp. as a Potential Cause of the Abandonment of Soft Contact Lenses by Their Existing Users.
    Biomed Res Int 2015 21;2015:259109. Epub 2015 Jul 21.
    Department of General Biology and Parasitology, Medical University of Warsaw, Ulica Chałubińskiego 5, 02-004 Warsaw, Poland ; Institute of Parasitology, Polish Academy of Sciences, Ulica Twarda 51/55, 00-818 Warsaw, Poland.
    Demodex mites may be a potential etiological factor in the development of various eye and skin disorders. The aim of the study was to investigate the presence of Demodex in the hair follicles of eyelashes and their potential influence on abandoning soft contact lenses which had been previously well tolerated by their users. A group of 62 users of contact lenses (28 with emerging discomfort and 34 without discomfort) were examined. Read More

    Bacterial isolates and their antimicrobial susceptibility pattern among patients with external ocular infections at Borumeda hospital, Northeast Ethiopia.
    BMC Ophthalmol 2015 Aug 14;15:103. Epub 2015 Aug 14.
    Department of Medical Microbiology, School of Biomedical and Laboratory sciences, CMHS, UOG, P.O. box 196, Gondar, Ethiopia.
    Background: Bacteria are major cause of ocular infections and possible loss of vision. The emergence of antimicrobial resistant bacteria increases the risk of treatment failure with potentially serious consequences. The aim of this study was to determine the prevalence of bacterial isolates and their antimicrobial susceptibility pattern among patients with external ocular infections. Read More

    Ocular Manifestations of Acquired Immunodeficiency Syndrome.
    Korean J Ophthalmol 2015 Aug 21;29(4):241-8. Epub 2015 Jul 21.
    Department of Ophthalmology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
    Purpose: To investigate the patterns and risk factors of the ocular manifestations of acquired immunodeficiency syndrome (AIDS) and their correlation with CD4+ count in the era of highly active antiretroviral therapy (HAART).

    Methods: This retrospective study examined 127 AIDS patients who presented to Soonchunhyang University Hospital. Data were collected from patient interviews, clinical examinations, and laboratory investigations. Read More

    Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease.
    JAMA Ophthalmol 2015 Oct;133(10):1117-23
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas.
    Importance: Topical application of azithromycin suppresses expression of proinflammatory mediators while restoring transforming growth factor β1 (TGF-β1) levels as evaluated by eyelid margin and conjunctival impression cytology.

    Objective: To explore the effects of azithromycin therapy on expression of proinflammatory and anti-inflammatory mediators in meibomian gland disease (MGD).

    Design, Setting, And Participants: Case-control study performed in a clinic setting from August 17, 2010, to December 31, 2010. Read More

    Efficacy and Safety of Topical Atorvastatin for the Treatment of Dry Eye Associated with Blepharitis: A Pilot Study.
    Ophthalmic Res 2015 5;54(1):26-33. Epub 2015 Jun 5.
    Save Sight Institute, University of Sydney, Sydney, N.S.W., Australia.
    Aims: To elucidate if topically applied atorvastatin safely decreases corneal fluorescein staining in dry eyes associated with blepharitis.

    Methods: Ten dry eye and blepharitis (DEB) patients were enroled in a prospective pilot study. All patients were treated with topical atorvastatin (50 μM) 8 times a day for 4 weeks and allowed to continue with their existing dry eye treatment. Read More

    [Bacterial flora in blepharitis].
    J Fr Ophtalmol 2015 Oct 14;38(8):723-8. Epub 2015 May 14.
    Service de bactériologie, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours, France; UMR1282 ISP, université François-Rabelais de Tours, 37032 Tours, France; INRA, UMR1282 ISP, 37380 Nouzilly, France.
    Introduction: Blepharitis has multiple, poorly defined origins. The goal of this study was to investigate the bacterial flora present in patients affected with blepharitis in comparison with healthy subjects, so as to understand the role of bacterial etiologies in blepharitis.

    Materials And Methods: Fifty-four patients with blepharitis and 50 healthy controls participated in this study. Read More

    [Demodex spp in chronic blepharitis patients].
    Rev Chilena Infectol 2015 Feb;32(1):37-42
    Background: Blepharitis is a very common disease in the ophthalmologic practice generally taking a chronic course with intermittent exacerbations. Several studies have linked the presence of Demodex folliculorum with chronic blepharitis, since the mite has the capacity to perpetuate the follicular inflammatory process. The prevalence of infection by Demodex spp. Read More

    Variability of Tear Osmolarity in Patients With Dry Eye.
    JAMA Ophthalmol 2015 Jun;133(6):662-7
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia.
    Importance: Knowledge about the variability of measurements using the TearLab Osmolarity System is necessary when evaluating the clinical utility of readings.

    Objective: To examine the variability of tear osmolarity measured by the TearLab Osmolarity System in patients with Sjögren syndrome (SS), patients with blepharitis, and control participants.

    Design, Setting, And Participants: Cross-sectional study at a tertiary care academic center from June 13, 2012, to March 21, 2013. Read More

    Long-Term Bleb-Related Infections After Trabeculectomy: Incidence, Risk Factors, and Influence of Bleb Revision.
    Am J Ophthalmol 2015 Jun 5;159(6):1082-91. Epub 2015 Mar 5.
    Jules Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address:
    Purpose: To report the incidence of late-onset bleb-related infections and to identify risk factors for bleb-related infections after trabeculectomy for the treatment of glaucoma.

    Design: Retrospective case series.

    Methods: Bleb-related infections were defined as blebitis, endophthalmitis, or blebitis with endophthalmitis. Read More

    Conjunctival geographic ulcer: an overlooked sign of herpes simplex virus infection.
    J Clin Virol 2015 Mar 5;64:40-4. Epub 2015 Jan 5.
    Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
    Herpes simplex virus (HSV) ocular infection causes significant visual burden worldwide. Despite the fact that dendritic or geographic corneal ulcers are typical findings in HSV epithelial keratitis, conjunctival ulcer as a sign of HSV infection has rarely been reported. Although easily overlooked, this important sign could be enhanced by fluorescein staining. Read More

    A case of pachyonychia congenita with unusual manifestations: an unusual type or a new syndrome?
    Int J Dermatol 2015 Mar 29;54(3):334-7. Epub 2013 Oct 29.
    Ankara Numune Education and Research Hospital, Dermatology Department, Ankara, Turkey.
    A 30-year-old man presented with lesions on his oral mucosa and soles. There were no similar complaints in his family members. The dermatological examination revealed follicular hyperkeratosis on his trunk and upper extremities and flesh-colored, firm cystic lesions on his axillae. Read More

    [Treatment of chronic allergic blepharoconjunctivitis].
    Vestn Oftalmol 2014 Sep-Oct;130(5):78, 80-4
    Objective: to evaluate the effectiveness of therapeutic eyelid hygiene in the treatment of chronic, or perennial, allergic blepharoconjunctivitis (ABC).

    Material And Methods: A total of 30 patients with chronic ABC (11 men, 19 women aged 25-41 years; disease duration 2-4 years) were examined before and after a treatment course which included instillations of olopatodine hydrochloride instillations (1 mg/ml, 2 times daily) and hyaluronic acid (2 mg/ml, 3-4 times daily). Patients from the main group (18 patients, 36 eyes) additionally practiced therapeutic eyelid hygiene using Blepharoshampoo, Blepharolotion or Blepharosalfetka, and Blepharogel-1 (2 times daily). Read More

    Prospective study of ocular manifestations of pemphigus and bullous pemphigoid identifies a high prevalence of dry eye syndrome.
    Cornea 2015 Apr;34(4):443-8
    *Faculty of Medicine, University of New South Wales, Sydney Australia; †Department of Ophthalmology, Prince of Wales Hospital, Sydney, Australia; ‡Department of Dermatology, St George Hospital, Sydney, Australia; and §Ophthalmic Surgeons, Sydney, Australia.
    Purpose: To study the range of ocular manifestations in an Australian cohort of patients with pemphigus and bullous pemphigoid (BP), including a detailed assessment for dry eye syndrome (DES).

    Methods: Twenty-two patients with pemphigus vulgaris, pemphigus foliaceus, and BP were referred for a detailed ophthalmology review between September 2011 and March 2012.

    Results: A total of 44 eyes of 22 patients with pemphigus vulgaris, pemphigus foliaceus, and BP were examined. Read More

    Orbital apex syndrome: an unusual complication of herpes zoster ophthalmicus.
    BMC Infect Dis 2015 Jan 31;15:33. Epub 2015 Jan 31.
    Division of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
    Background: Herpes zoster ophthalmicus is defined as herpes zoster involvement of the ophthalmic division of the trigeminal nerve. Ocular involvement occurs in 20-70% of patients with herpes zoster ophthalmicus and may include blepharitis, keratoconjunctivitis, iritis, scleritis, and acute retinal necrosis. Orbital apex syndrome is a rare but severe ocular complication of herpes zoster ophthalmicus. Read More

    Refractive outcome of wavefront guided laser in situ keratomileusis and wavefront guided photorefractive keratectomy in high pre-existing higher order aberration.
    Cont Lens Anterior Eye 2015 Apr 30;38(2):127-33. Epub 2014 Dec 30.
    Guru Nanak Eye Centre, Maharaja Ranjit Singh Marg, New Delhi 110002, India.
    Purpose: To compare visual outcome and higher order aberrations (HOA) between wavefront-guided LASIK (WF-LASIK) and wavefront guided PRK (WF-PRK) in patients with high preoperative HOA.

    Methods: Randomized prospective interventional study. Conducted at Guru Nanak Eye Centre, Maulana Azad Medical College, Delhi, India. Read More

    Comparative study of the efficacy of different treatment options in patients with chronic blepharitis.
    Arch Soc Esp Oftalmol 2015 Mar 23;90(3):112-8. Epub 2014 Dec 23.
    Ludwig-Maximilians University, Munich, Alemania.
    Objective: To compare the efficacy of 3 treatment options in patients with chronic blepharitis.

    Methodology: An experimental, randomized, controlled study was conducted on 45 patients (female 67%; Mean age: 40.5 years) diagnosed with chronic blepharitis, in order to compare the effectiveness of three treatment options. Read More

    Epidemiology and Associated Morbidity of Pterygium: A Large, Community-Based Case-Control Study.
    Semin Ophthalmol 2016 13;31(5):446-51. Epub 2014 Nov 13.
    d Department of Ophthalmology , Barzilai Medical Center, Ashkelon, Israel, Faculty of Health Sciences, Ben-Gurion University , Beer-Sheva , Israel.
    Background: To evaluate the prevalence and risk factors of various conditions among patients with pterygium.

    Methods: A retrospective observational case control study of 4,037 patients who were diagnosed with pterygium in the Central District of Clalit Health Services in Israel from 2000-2009. A total of 16,054 randomly selected controls from the district HMO members. Read More

    Ophthalmological features of Parkinson disease.
    Med Sci Monit 2014 Nov 11;20:2243-9. Epub 2014 Nov 11.
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
    Background: The aim of this study was to determine the type and frequency of ophthalmologic changes occurring in patients with Parkinson disease (PD).

    Material/methods: One hundred consecutive patients (196 eyes) with idiopathic PD and a control group consisting of 100 healthy patients (196 eyes) matched for age and sex underwent a complete ophthalmological examination of both eyes, including assessment of patient medical history, dry eye questionare, and visual hallucinations questionnaire, distance and near best corrected visual acuity (DBCVA, NBCVA), color vision, distance photopic contrast sensitivity, near point of convergence, slit lamp examination of the eye anterior segment, tear film osmolarity and breakup time, aqueous tear production, and intraocular pressure, as well as fundus examination and evaluation of the perimacular retinal thickness (RT) and peripapillary retinal nerve fiber layer (RNFL) thickness.

    Results: In the eyes of PD patients DBCVA, NBCVA, contrast sensitivity, and color discrimination were significantly reduced. Read More

    Epiphora after Uncomplicated Phacoemulsification: Study of Prevalence and Associated Factors.
    Semin Ophthalmol 2016 6;31(3):271-4. Epub 2014 Nov 6.
    a Hospital Clínico San Carlos , Madrid , Spain.
    Purpose: To describe the prevalence of epiphora and associated factors after uncomplicated phacoemulsification.

    Methods: Prospective and descriptive design. A group of 125 patients was asked about tearing one to two weeks after cataract surgery. Read More

    Blepharitis: always remember demodex.
    Middle East Afr J Ophthalmol 2014 Oct-Dec;21(4):317-20
    Department of Cornea and External Diseases, Sankara eye Centre, Coimbatore, Tamil Nadu, India.
    Purpose: To determine the incidence and density of Demodex species on the eyelashes of subjects with normal eyelids, anterior blepharitis (AB), meibomian-gland dysfunction (MGD), and mixed blepharitis (MB).

    Materials And Methods: One hundred and fifty consecutive patients diagnosed with AB, MGD, and MB were recruited. An additional 50 individuals were recruited who were free of lid and margin disease to serve as a control group. Read More

    An unusual presentation of Pseudomonas aeruginosa blebitis following combined surgery.
    Indian J Ophthalmol 2014 Sep;62(9):958-60
    Glaucoma Speciality Clinic, Aravind Eye Hospital, Coimbatore, Tamil Nadu, India.
    We report a case of blebitis that occurred 3 years later following a combined glaucoma and cataract surgery. It was an atypical presentation, as patient had no classical fiery looking signs of blebitis despite the isolated organism being Pseudomonas aeruginosa. Improvized surgical techniques like use of Mitomycin C, releasable flap sutures though considered as part of the recommended procedure for better surgical outcomes, their role as potential risk factors for visually blinding complications like endophthalmitis are often overlooked. Read More

    Floppy eyelid syndrome: the coventry experience.
    Orbit 2014 Dec 25;33(6):399-405. Epub 2014 Sep 25.
    University Hospital Coventry and Warwickshire NHS Trust , Coventry, West Midlands , United Kingdom.
    Purpose: Floppy eyelid syndrome is a condition that is difficult to identify and diagnose and with no clear guidelines on its management. We propose a method of reliably grading this syndrome and have proposed a management algorithm based on the grading.

    Materials And Methods: Retrospective data collection of patients diagnosed with Floppy eyelid syndrome and treated under the care of a single oculoplastic surgeon over a 9 year period. Read More

    In vivo confocal microscopy as a novel and reliable tool for the diagnosis of Demodex eyelid infestation.
    Br J Ophthalmol 2015 Mar 24;99(3):336-41. Epub 2014 Sep 24.
    Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, Paris, France Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU ViewMaintain, INSERM-DHOS CIC, Paris, France INSERM, U968, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris, France CNRS, UMR_7210, Paris, France Department of Ophthalmology, Ambroise Paré Hospital, APHP, University of Versailles Saint-Quentin en Yvelines, Versailles, France.
    Aims: Demodex mites are implicated in several ocular surface diseases such as blepharitis, ocular rosacea and dry eye syndrome. Demodex eyelid infestation is classically diagnosed by analysing depilated eyelashes under the light microscope. The use of in vivo confocal microscopy (IVCM) could be an easy way to improve its diagnosis. Read More

    The heritability of dry eye disease in a female twin cohort.
    Invest Ophthalmol Vis Sci 2014 Sep 23;55(11):7278-83. Epub 2014 Sep 23.
    Department of Twin Research & Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, United Kingdom Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, United Kingdom.
    Purpose: We estimated the relative importance of genes and environment in dry eye disease (DED) using a classic twin study.

    Methods: A large sample of 3930 female monozygotic and dizygotic twins from the UK Adult Twin Registry (TwinsUK) was questioned about the presence of a DED diagnosis and about DED symptoms in the preceding 3 months. In addition, a subset of 606 twins was examined for several dry eye signs. Read More

    Ocular rosacea: an underdiagnosed cause of relapsing conjunctivitis-blepharitis in the elderly.
    BMJ Case Rep 2014 Sep 19;2014. Epub 2014 Sep 19.
    Unit of Internal Medicine, Department of Medicine and Pathology Clinical and Experimental, S. Maria della Misericordia Academic Hospital, University of Udine Medical School, Udine, Italy.
    Red eye and relapsing conjunctivitis-blepharitis are among the most common ocular disease in elderly patients. In these cases the search for causes is difficult and frustrating. We report the case of a 79-year-old woman with a long history of red eye and relapsing conjunctivitis-blepharitis caused by ocular rosacea. Read More

    Sparfloxacin-associated corneal epithelial toxicity.
    BMJ Case Rep 2014 Sep 19;2014. Epub 2014 Sep 19.
    Advanced Eye Centre, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
    Sparfloxacin is a broad-spectrum fluoroquinolone antibiotic commonly used for various bacterial corneal infections. Topical use of fluoroquinolones is considered to be safe leading to their widespread use. Common indications include blepharitis, conjunctivitis and corneal ulcers. Read More

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