512,880 results match your criteria Bleeding and Coagulation in Trauma[Journal]


CoVID-19 insights from transfusion medicine.

Authors:
Willy A Flegel

Br J Haematol 2020 Jul 8. Epub 2020 Jul 8.

Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA.

The emergence of CoVID-19 infection in the first months of 2020 resulted in a massive surge in admissions to hospitals and intensive care units due to the nature of the respiratory pathophysiology. In some countries, health care systems were rapidly overwhelmed, while in others their hospitals coped with the first wave and all patients received the level of care needed, depending upon both the containment measured and the level of development of the heath care systems. Read More

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http://dx.doi.org/10.1111/bjh.17005DOI Listing

Blood Component Use in Critical Care in Patients with COVID-19 Infection: A Single Centre Experience.

Br J Haematol 2020 Jul 8. Epub 2020 Jul 8.

Department of Critical Care, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.

There has been a significant surge in admissions to critical care during the COVID-19 pandemic. At present, the demands on blood components have not been described. We reviewed their use during the first 6 weeks of the outbreak from 3 March 2020 in a tertiary-level critical care department providing veno-venous extracorporeal membrane oxygenation (vv-ECMO). Read More

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http://dx.doi.org/10.1111/bjh.17007DOI Listing

Predicting the risk of rebleeding after capsule endoscopy in obscure gastrointestinal bleeding - External validation of the RHEMITT Score.

Dig Dis 2020 Jul 8. Epub 2020 Jul 8.

Background And Aims: Prediction of rebleeding after small bowel capsule endoscopy (SBCE) in obscure gastrointestinal bleeding (OGIB) is challenging. The recently described RHEMITT score includes 7 variables: chronic kidney disease (CKD); heart failure (HF); P1/P2 lesions (Saurin's classification); major bleeding; incomplete examination; smoking and endoscopic treatment. This tool has been shown to accurately predict the risk of recurrence after a SBCE study. Read More

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http://dx.doi.org/10.1159/000509986DOI Listing

Risk Factors for Spinal Cord Injury and Complications of Cerebrospinal Fluid Drainage in Patients Undergoing Fenestrated and Branched Endovascular Aneurysm Repair.

J Vasc Surg 2020 Jul 5. Epub 2020 Jul 5.

Division of Vascular and Endovascular Surgery, Weill Cornell Medicine, New York-Presbyterian Hospital, New York. Electronic address:

Objective: Spinal cord injury (SCI) is one of the most devastating complications of thoracoabdominal aortic aneurysm (TAAA) repair. Cerebrospinal fluid drainage (CSFD) is routinely used to prevent and treat SCI during open TAAA repair. However, the risks and benefits of CSFD during fenestrated-branched endovascular aneurysm repair (F-BEVAR) are unclear. Read More

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http://dx.doi.org/10.1016/j.jvs.2020.05.070DOI Listing

Long-term outcome of postmenopausal women with proliferative endometrium on endometrial sampling.

Am J Obstet Gynecol 2020 Jul 5. Epub 2020 Jul 5.

Introduction: Proliferative endometrium has been reported in 15% of endometrial biopsies of women 50 and older. In contrary to endometrial hyperplasia, proliferative endometrium has not been associated with risk of endometrial cancer. We sought to report on the long-term outcome of postmenopausal women diagnosed with proliferative endometrium. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.06.045DOI Listing

A microchip flow-chamber assay screens congenital primary hemostasis disorders.

Pediatr Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan.

Background: Von Willebrand disease (VWD) and platelet function disorders (PFDs) are congenital bleeding disorders caused by primary hemostasis defects. Platelet function tests are time-consuming and require considerable amounts of blood sample, and there were no easy-to-use assays for assessing platelet function quickly and sensitively. We reported the usefulness of a microchip flow-chamber system (T-TAS ) for detecting and/or predicting clinical severities in patients with VWD type 1 and 2N and platelet storage pool disease. Read More

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http://dx.doi.org/10.1111/ped.14378DOI Listing

An Improved Classification and Localization Approach to Small Bowel Capsule Endoscopy Using Convolutional Neural Network.

Dig Endosc 2020 Jul 8. Epub 2020 Jul 8.

Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Although great advances in artificial intelligence for interpreting small bowel capsule endoscopy (SBCE) images have been made in recent years, its practical use is still limited. The aim of this study was to develop a more practical convolutional neural network (CNN) algorithm for the automatic detection of various small bowel lesions.

Methods: A total of 7,556 images were collected for the training dataset from 526 SBCE videos. Read More

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http://dx.doi.org/10.1111/den.13787DOI Listing

A Pilot Randomized Controlled Crossover Trial Comparing Early OHRQoL Outcomes of Cobalt-Chromium Versus PEEK Removable Partial Denture Frameworks.

Int J Prosthodont 2020 Jul/Aug;33(4):386-392

Purpose: To investigate differences in the performance of polyether ether ketone (PEEK) frameworks vs traditional metal frameworks for removable partial dentures (RPDs) in terms of OHRQoL, patient preference, periodontal indices, and denture satistfaction.

Materials And Methods: Twenty-six participants were recruited to a randomized controlled crossover trial and were provided with either PEEK or cobalt-chromium (Co-Cr) RPDs. After 4 weeks, the participants were provided with the other RPD. Read More

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http://dx.doi.org/10.11607/ijp.6604DOI Listing

Molecular and clinical profile of congenital fibrinogen disorders in Iran, identification of two novel mutations.

Int J Lab Hematol 2020 Jul 8. Epub 2020 Jul 8.

Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Congenital fibrinogen disorders (CFDs) comprise the quantitative and qualitative fibrinogen molecule abnormalities that are caused by fibrinogen gene mutations. The objective of this cohort research was to study the molecular and clinical profiles of patients with CFDs.

Materials And Methods: Genomic DNA Sanger sequencing of 14 Iranian patients was performed to determine CFDs-causing mutations. Read More

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http://dx.doi.org/10.1111/ijlh.13258DOI Listing

Non-vitamin K Oral Anticoagulants in Hypertrophic Cardiomyopathy Patients Undergoing Catheter Ablation of Atrial Fibrillation.

J Cardiovasc Electrophysiol 2020 Jul 8. Epub 2020 Jul 8.

Barts Heart Centre, St. Bartholomew's Hospital, London, United Kingdom.

Introduction: Patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) require chronic anticoagulation due to a high thromboembolic risk. Evidence supporting use of non-vitamin K oral anticoagulants (NOACs) in patients with HCM remains sparse, and there are no data regarding the use of NOACs in HCM patients undergoing catheter ablation of AF.

Methods: Observational non-randomised study in 4 European Centres. Read More

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http://dx.doi.org/10.1111/jce.14659DOI Listing

A multicenter, open-label, phase II study of tirabrutinib (ONO/GS-4059) in patients with Waldenström's macroglobulinemia.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Hematology, National Cancer Center Hospital, Tokyo, Japan.

Tirabrutinib is a second-generation Bruton's tyrosine kinase inhibitor with greater selectivity than ibrutinib. Here we conducted a multicenter, phase II study of tirabrutinib in patients with treatment-naïve (Cohort A) or with relapsed/refractory (Cohort B) Waldenström's macroglobulinemia (WM). Patients were treated with tirabrutinib 480 mg once daily. Read More

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http://dx.doi.org/10.1111/cas.14561DOI Listing

Identifying Fatal Head Injuries on Postmortem Computed Tomography Using Convolutional Neural Network/Deep Learning: A Feasibility Study.

J Forensic Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Forensic Pathology, LabPLUS, Auckland City Hospital, 2 Park Road, Grafton, Auckland, New Zealand, 1023.

Postmortem computed tomography (PMCT) is a relatively recent advancement in forensic pathology practice that has been increasingly used as an ancillary investigation and screening tool. One area of clinical CT imaging that has garnered a lot of research interest recently is the area of "artificial intelligence" (AI), such as in screening and computer-assisted diagnostics. This feasibility study investigated the application of convolutional neural network, a form of deep learning AI, to PMCT head imaging in differentiating fatal head injury from controls. Read More

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http://dx.doi.org/10.1111/1556-4029.14502DOI Listing

Direct Oral to Parenteral Anticoagulants: Strategies for Inpatient Transition.

J Clin Pharmacol 2020 Jul 8. Epub 2020 Jul 8.

Department of Pharmacy, Houston Methodist Hospital, Houston, Texas, USA.

The primary objective of this study was to describe the impact on bleeding rates of 2 different strategies for transitioning from a direct oral anticoagulant (DOAC) to a parenteral anticoagulant: a delayed, clinically driven strategy versus the standard per-package-insert strategy. This was a single-center descriptive cohort study conducted at a large academic medical center. Included patients were 18 years or older, admitted as an inpatient, and had received at least 1 dose of a DOAC prior to initiation of therapeutic parenteral anticoagulation. Read More

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http://dx.doi.org/10.1002/jcph.1694DOI Listing

Using the Case-crossover Design to Assess Short-term Risks of Bleeding and Arterial Thromboembolism Following Switching Between Oral Anticoagulants in a Population-based Cohort of Atrial Fibrillation Patients.

Am J Epidemiol 2020 Jul 8. Epub 2020 Jul 8.

Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.

Using nationwide Danish registries, we conducted a population-based case-crossover study evaluating the association between switching from a vitamin K antagonist (VKA) to a direct oral anticoagulant (DOAC), and vice-versa, and 30-day risks of bleeding and arterial thromboembolism in atrial fibrillation (AF) patients. The case-crossover population was identified among oral anticoagulant users during 2011-2018 (n = 123,217), as AF patients with (a) a case-defining outcome and (b) an anticoagulant switch during the 180 days preceding the outcome. Odds Ratios were estimated using conditional logistic regression by comparing the occurrence of switching during the 30-day window immediately preceding the outcome to that in reference windows in the same individual 60-180 days before the outcome. Read More

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http://dx.doi.org/10.1093/aje/kwaa133DOI Listing

The optimal duration of dual antiplatelet therapy in East Asian patients undergoing percutaneous coronary intervention with drug-eluting stents: a meta-analysis of randomized trials.

Coron Artery Dis 2020 Jul 3. Epub 2020 Jul 3.

Department of Cardiology, Affiliated Hangzhou First People's Hospital, Nanjing Medical University, Shangcheng District, Hangzhou, Zhejiang Province, China.

Objective: The optimal duration of dual antiplatelet therapy (DAPT) is still controversial among East Asians. This meta-analysis was designed to evaluate the efficacy and safety of short-term (≤6 months) vs. long-term (≥12 months) DAPT in East Asians undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Read More

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http://dx.doi.org/10.1097/MCA.0000000000000921DOI Listing

Comparison of the effect of two internal fixation methods for proximal clavicle fractures.

Rev Assoc Med Bras (1992) 2020 May 3;66(5):654-658. Epub 2020 Jul 3.

Department of Orthopaedics, Dongying People's Hospital, Dongying, Shandong, China.

OBJECTIVE To compare the effect of two internal fixation methods in the treatment of proximal clavicle fractures. METHODS Fifty patients with proximal clavicle fractures received surgical treatment. They were divided into a clavicular T-plate group and a double mini-plates group. Read More

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http://dx.doi.org/10.1590/1806-9282.66.5.654DOI Listing

Weight and body yield of selectively bred tambaqui (Colossoma macropomum) farmed in different environments.

An Acad Bras Cienc 2020 3;92 Suppl 1:e20180675. Epub 2020 Jul 3.

Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.

The objective of this study was to evaluate the weight and body yield of two families of selectively bred tambaqui farmed in different environments. Two families (FA and FB) were reared in the municipalities (environments) of Santo Antônio de Leverger (MT) and Campo Grande (MS) for 431 days. Pre-bleeding weight, body yield, and the interaction effect between families and environments on these traits were investigated. Read More

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http://dx.doi.org/10.1590/0001-3765202020180675DOI Listing

Horseshoe Kidney Blunt Trauma With Double Laceration: Endovascular Management.

Vasc Endovascular Surg 2020 Jul 8:1538574420940091. Epub 2020 Jul 8.

Department of Radiology, ASST Mantova, Mantua, Italy.

A 78-year-old male patient was admitted to our hospital after abdominal trauma. Contrast-enhanced computed tomography (CT) scan demonstrated a horseshoe kidney with a perinephric hematoma and evidence of arterial hemorrhage. An anomalous renal arterial anatomy was noted as well, with a renal artery originating from the left common iliac artery. Read More

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http://dx.doi.org/10.1177/1538574420940091DOI Listing

Worse prognosis in women, compared with men, after thrombolysis: An individual patient data pooling study of Asian acute stroke registries.

Int J Stroke 2020 Jul 8:1747493020938307. Epub 2020 Jul 8.

The George Institute for Global Health, University of New South Wales, NSW, Australia.

Background And Purpose: To examine sex differences in disease profiles and short-term outcomes after acute ischemic stroke treated with recombinant tissue plasminogen activator.

Methods: Eight national and regional stroke registries contributed individual participant data from mainland China, Japan, Philippines, Singapore, South Korea and Taiwan in 2005-2018. The primary outcome was ordinal-modified Rankin scale at 90 days. Read More

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http://dx.doi.org/10.1177/1747493020938307DOI Listing

Systematic Literature Review of Randomized Trials Comparing Antithrombotic Therapy Following Revascularization Procedures in Patients With Peripheral Artery Disease.

Angiology 2020 Jul 8:3319720936505. Epub 2020 Jul 8.

Bayer AG, Berlin, Germany.

A systematic literature review was conducted to identify and summarize the clinical efficacy and safety of available antithrombotic therapies after peripheral endovascular or surgical revascularization in patients with peripheral artery disease (PAD). Five databases were searched using free-text and Emtree/Mesh terms for PAD, randomized controlled trials (RCTs), and antithrombotic therapies of interest (ie, single antiplatelet therapy, dual antiplatelet therapy, and vitamin K antagonists). Randomized controlled trials were eligible for inclusion if they assessed the risk of thrombotic events (ie, myocardial infarction, ischemic stroke, cardiovascular death, limb ischemia, or limb amputation) or safety profile (ie, minor, moderate, major, or fatal bleeding events) after revascularization. Read More

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http://dx.doi.org/10.1177/0003319720936505DOI Listing

Cesarean scar ectopic pregnancy: A cause of failed first trimester surgical termination of pregnancy (case report).

Authors:
Haitham A Torky

JBRA Assist Reprod 2020 Jul 8. Epub 2020 Jul 8.

Department of Obstetrics & Gynecology - October 6th University & As-Salam International Hospital, Cairo, Egypt.

Cesarean scar (ectopic) pregnancy is due to blastocyst implantation on a Caesarean scar. The current case presented by vaginal bleeding after a failed surgical termination of pregnancy. The ultrasound scan revealed a cesarean scar ectopic pregnancy managed by surgical removal. Read More

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http://dx.doi.org/10.5935/1518-0557.20200039DOI Listing

Effectiveness of prothrombin complex concentrate for the treatment of bleeding: A systematic review and meta-analysis.

J Thromb Haemost 2020 Jul 8. Epub 2020 Jul 8.

Department of Intensive Care Medicine, Amsterdam UMC, Amsterdam, The Netherlands.

Prothrombin complex concentrate(PCC) is increasingly being used as a treatment for major bleeding in patients who are not taking anticoagulants. The aim of this systematic review and meta-analysis is to evaluate the effectiveness of PCC administration for the treatment of bleeding in patients not taking anticoagulants. Studies investigating the effectivity of PCC to treat bleeding in adult patients and providing data on either mortality or blood loss were eligible. Read More

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http://dx.doi.org/10.1111/jth.14991DOI Listing

A comparison of figure-of-8-suture vs manual compression for venous access closure after cardiac procedures: An updated meta-analysis.

Pacing Clin Electrophysiol 2020 Jul 8. Epub 2020 Jul 8.

Pat and Jim Calhoun Cardiology Center, University of Connecticut, Farmington, CT, USA.

Background: Manual compression (MC) is the current standard to achieve post-procedural hemostasis in patients who need venous vascular access closure after cardiovascular procedures. Figure-of-8 (F8) suture for venous access closure has been reported to be a safe and efficacious alternative to MC.

Methods: A systematic search was done using PubMed, Google Scholar, EMBASE, SCOPUS and ClinicalTrials. Read More

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http://dx.doi.org/10.1111/pace.14008DOI Listing

Use, Persistence, Efficacy, and Safety of Apixaban in Patients with Non-Valvular Atrial Fibrillation in Unselected Patients in Germany. Results of the Prospective Apixaban in Atrial Fibrillation (APAF) Registry.

Cardiol Ther 2020 Jul 8. Epub 2020 Jul 8.

Kardiologische Praxisklinik Ludwigshafen, Ludwigshafen, Germany.

Introduction: Apixaban has been shown to be superior to warfarin in patients with non-valvular atrial fibrillation in the randomized ARISTOTLE trial and its use is recommended in current guidelines. There are only scarce data about its use, efficacy, and safety in unselected patients in Germany.

Methods And Results: The APAF registry is a prospective non-interventional study enrolling 5015 patients with non-valvular atrial fibrillation. Read More

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http://dx.doi.org/10.1007/s40119-020-00188-1DOI Listing

Low Risk for Marginal Ulcers in Duodenal Switch and Gastric Bypass in a Well-Defined Cohort of 472 Patients.

Obes Surg 2020 Jul 8. Epub 2020 Jul 8.

Department of Surgical Sciences, Uppsala University, SE-751 85, Uppsala, Sweden.

Purpose: Marginal ulcer (MU) is well-known complication in bariatric surgery. Several studies are available in Roux-en-Y gastric bypass (RYGBP), while data on the incidence in duodenal switch (DS) is limited. We aimed to compare the incidence of MU between DS and RYGBP in a well-defined cohort and to identify associative factors. Read More

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http://dx.doi.org/10.1007/s11695-020-04822-8DOI Listing

Editorial Commentary to Article "The Magnitude of Blood Pressure Reduction Predicts Poor In-hospital Outcome in Acute Intracerebral Hemorrhage" by Divani et al.

Authors:
Nils H Petersen

Neurocrit Care 2020 Jul 7. Epub 2020 Jul 7.

Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale Medical School, 15 York St, LCI 1003, New Haven, CT, 06510, USA.

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http://dx.doi.org/10.1007/s12028-020-01025-yDOI Listing

Digestive Reconstruction After Pharyngolaryngectomy with Total Esophagectomy.

Ann Surg Oncol 2020 Jul 7. Epub 2020 Jul 7.

Department of Head and Neck Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

Background: Pharyngolaryngectomy with total esophagectomy (PLTE) is often indicated for patients with synchronous head and neck cancer and thoracic esophageal cancer or those with head and neck cancer extending to the upper mediastinum. A long conduit is required for the reconstruction, and the blood flow at the tip of the conduit is not always sufficient. Thus, reconstructive surgery after PLTE remains challenging, and optimal reconstruction methods have not been elucidated to date. Read More

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http://dx.doi.org/10.1245/s10434-020-08830-xDOI Listing

Predictors of complete miscarriage after expectant management or misoprostol treatment of non-viable early pregnancy in women with vaginal bleeding.

Arch Gynecol Obstet 2020 Jul 7. Epub 2020 Jul 7.

Department of Obstetrics and Gynecology, Skåne University Hospital, Jan Waldenströms gata 47, 20502, Malmö, SE, Sweden.

Purpose: To identify predictors of complete miscarriage after expectant management or misoprostol treatment of non-viable early pregnancy in women with vaginal bleeding.

Methods: This was a planned secondary analysis of data from a published randomized controlled trial comparing expectant management with vaginal single dose of 800 µg misoprostol treatment of women with embryonic or anembryonic miscarriage. Predefined variables-serum-progesterone, serum-β-human chorionic gonadotropin, parity, previous vaginal deliveries, gestational age, clinical symptoms (bleeding and pain), mean diameter and shape of the gestational sac, crown-rump-length, type of miscarriage, and presence of blood flow in the intervillous space-were tested as predictors of treatment success (no gestational sac in the uterine cavity and maximum anterior-posterior intracavitary diameter was ≤ 15 mm as measured with transvaginal ultrasound on a sagittal view) in univariable and multivariable logistic regression. Read More

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http://dx.doi.org/10.1007/s00404-020-05672-6DOI Listing

Intraoperative hemorrhage and increased spleen volume are risk factors for conversion to open surgery in patients undergoing elective robotic and laparoscopic splenectomy.

Turk J Surg 2020 Mar 18;36(1):72-81. Epub 2020 Mar 18.

Clinic of General Surgery, Sakarya University Training and Research Hospital, Sakarya, Turkey.

Objectives: Minimal invasive surgery is one of the most popular treatment approaches which is safe and effective in experienced hands in different clinical practices. In the present study, we aimed to evaluate the risks factors for conversion to open splenectomy and the performance of indirect hilum dissection technique.

Material And Methods: A total of 56 patients who underwent laparoscopic or robotic splenectomy for isolated spleen diseases were included into the study. Read More

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http://dx.doi.org/10.5578/turkjsurg.4535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315453PMC

Early High Cerebrospinal Fluid Glutamate: A Potential Predictor for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage.

ACS Omega 2020 Jun 16;5(25):15385-15389. Epub 2020 Jun 16.

Key Lab of Cerebral Microcirculation, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, People's Republic of China.

Delayed cerebral ischemia (DCI) is an important complication after aneurysmal subarachnoid hemorrhage (aSAH). Early identification of cerebrospinal fluid (CSF) markers is helpful for warning of impending DCI. This study assessed whether early high CSF glutamate levels can be observed in aSAH patients who later developed DCI. Read More

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http://dx.doi.org/10.1021/acsomega.0c01472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331073PMC

Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing.

Bioact Mater 2020 Dec 21;5(4):768-778. Epub 2020 Jun 21.

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, PR China.

Uncontrolled bleeding and infection can cause significant increases in mortalities. Hydrogel sealants have attracted extensive attention for their ability to control bleeding. However, because interfacial water is a formidable barrier to strong surface bonding, a challenge remains in finding a product that offers robust tissue adhesion combined with anti-infection properties. Read More

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http://dx.doi.org/10.1016/j.bioactmat.2020.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317234PMC
December 2020

Refining prediction of major bleeding on antiplatelet treatment after transient ischaemic attack or ischaemic stroke.

Eur Stroke J 2020 Jun 19;5(2):130-137. Epub 2020 Jan 19.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands.

Introduction: Bleeding is the main safety concern of treatment with antiplatelet drugs. We aimed to refine prediction of major bleeding on antiplatelet treatment after a transient ischaemic attack (TIA) or stroke by assessing the added value of new predictors to the existing STOP-BLEED score.

Patients And Methods: We used Cox regression analysis to study the association between candidate predictors and major bleeding among 2072 patients with a transient ischaemic attack or ischaemic stroke included in a population-based study (Oxford Vascular Study - OXVASC). Read More

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http://dx.doi.org/10.1177/2396987319898064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309362PMC

Meta-analysis study on direct oral anticoagulants vs warfarin therapy in atrial fibrillation and PCI: Dual or triple approach?

Int J Cardiol Heart Vasc 2020 Aug 28;29:100569. Epub 2020 Jun 28.

Department of Medical & Surgical Sciences, University of Foggia, Foggia, Italy.

Background: Dual antiplatelet therapy and anticoagulants may be required in the case of coexistence of coronary artery disease and atrial fibrillation (AF) undergoing (PCI), with associated increased bleeding rates. The introduction of direct oral anticoagulants (DOACs), however, significantly reduced the incidence of bleeding complications in this clinical setting of patients. We therefore sought to assess whether the recent publication of the AUGUSTUS and ENTRUST-AF PCI studies significantly impacted current evidence on the use of DOACs in AF patients treated with PCI. Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330069PMC

Clitoral metastasis from uterine cervical cancer: A case report and review of the literature.

Gynecol Oncol Rep 2020 Aug 8;33:100591. Epub 2020 Jun 8.

Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.

A 81-year-old woman vaginal bleeding and vulvar pain. Pretreatment work-up revealed a 4.5 cm cervical cancer extended to the lower-third of the vagina and an isolated clitoral metastasis. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327413PMC

Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity.

Mol Ther Methods Clin Dev 2020 Sep 3;18:259-268. Epub 2020 Jun 3.

Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Adeno-associated virus (AAV) vectors have been successfully used in patients with bleeding disorders and blindness. For human liver targeting, two major factors restrict effective AAV transduction after systemic administration of AAV vectors: human hepatocyte tropism and neutralizing antibodies (Nabs). In this study, we attempted to isolate AAV variants with the ability to transduce human hepatocytes and escape Nabs using a directed evolution approach . Read More

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http://dx.doi.org/10.1016/j.omtm.2020.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329936PMC
September 2020

Severe Small Bowel Bleeding Associated With Metastatic Clear Cell Renal Cell Carcinoma to the Jejunum.

ACG Case Rep J 2020 Jun 11;7(6):e00397. Epub 2020 Jun 11.

Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH.

Clear cell renal cell carcinoma is a malignancy of the kidneys that most commonly metastasizes to lung, bone, lymph nodes, liver, adrenal glands, and brain. We present a 75-year-old man with severe and chronic gastrointestinal bleeding who was eventually discovered to have clear cell renal cell carcinoma metastatic to his jejunum as the source of his bleed. This is a rare phenomenon and an unusual cause of gastrointestinal bleeding. Read More

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http://dx.doi.org/10.14309/crj.0000000000000397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304539PMC

Large Necrotic Mass in the Small Bowel.

ACG Case Rep J 2020 Jun 11;7(6):e00393. Epub 2020 Jun 11.

Yale-Waterbury Internal Medicine Residency Program, Waterbury, CT.

Melanoma of unknown primary (MUP) is a melanoma found in sites other than the skin, mucosa, or eye. It is most commonly present in lymph nodes and least frequently in visceral organs. Diagnosis is difficult given its internal presentation and is often late stage with poor prognosis. Read More

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http://dx.doi.org/10.14309/crj.0000000000000393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304532PMC

Comparative Effects Between Direct Oral Anticoagulants for Acute Venous Thromboembolism: Indirect Comparison From Randomized Controlled Trials.

Front Med (Lausanne) 2020 19;7:280. Epub 2020 Jun 19.

Department of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, ON, Canada.

There is no direct comparison from clinical trials amongst the direct oral anticoagulants (DOACs) in patients with acute venous thromboembolism (VTE), leaving an evidence gap in decision-making regarding the choice of a DOAC. We performed a systematic review for an indirect comparison from randomized controlled trials (RCTs) for comparative effects amongst DOACs in the patients with acute VTE. A total of 16 RCTs were included for analyses, among which three for dabigatran ( = 7,963 patients), six rivaroxaban ( = 17,935), five apixaban ( = 12,823), and two edoxaban ( = 9,286). Read More

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http://dx.doi.org/10.3389/fmed.2020.00280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316891PMC

Postmenopausal bleeding in a woman with caesarean scar defect: A case report.

Case Rep Womens Health 2020 Jul 25;27:e00235. Epub 2020 Jun 25.

Department of Obstetrics and Gynaecology, Singapore General Hospital, Outram Road, 169608, Singapore.

Background: Caesarean scar defect (CSD) is a complication of caesarean section with implications for abnormal uterine bleeding. Most cases of CSD are discovered incidentally or with the development of menstrual changes. However, CSD may rarely have a longer latency period, resulting in postmenopausal presentation of bleeding and abdominal pain. Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327884PMC

Emergent Management of a Tracheoinnominate Fistula in the Community Hospital Setting.

Cureus 2020 Jun 2;12(6):e8403. Epub 2020 Jun 2.

Heart, Vascular, Thoracic Institute, Cleveland Clinic, Cleveland, USA.

Tracheoinnominate fistula is a rare but highly lethal complication of tracheostomy. Early recognition and interventions are key to patient survival. A 63-year-old woman had undergone tracheostomy for respiratory failure secondary to disseminated histoplasmosis. Read More

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http://dx.doi.org/10.7759/cureus.8403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331894PMC

Uncommon Presentations of Multiple Myeloma.

Cureus 2020 Jun 1;12(6):e8400. Epub 2020 Jun 1.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Multiple myeloma is a rare malignancy that exhibits a wide range of possible clinical presentations. In recent years, with the advent of stem cell transplantation, the prognosis of patients with multiple myeloma has been increasing. We searched the literature for reports of atypical myeloma presentations to aid clinicians in formulating differential diagnoses and to increase the number of cases diagnosed early. Read More

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http://dx.doi.org/10.7759/cureus.8400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331905PMC

Paramedian thalamic infarction caused by cisternal drain placement in open clipping for aneurysmal subarachnoid hemorrhage: Two case reports.

Surg Neurol Int 2020 27;11:164. Epub 2020 Jun 27.

Department of Neurosurgery, NTT Medical Center Tokyo, Shinagawa, Tokyo.

Background: Some complications associated with cisternal drainage have been reported; however, there are few reports on direct vascular injury caused by cisternal drain. We experienced two rare cases of thalamic infarction caused by cisternal drain placement during open clipping for a ruptured anterior communicating artery (AcomA) aneurysm through an anterior interhemispheric approach.

Case Description: Two cases of ruptured AcomA aneurysm were treated by surgical clipping through an anterior interhemispheric approach, and then a cisternal drain was inserted from opticocarotid space toward prepontine cistern. Read More

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http://dx.doi.org/10.25259/SNI_47_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332699PMC

A spontaneous cervical epidural hematoma mimicking a stroke - A case report.

Surg Neurol Int 2020 20;11:157. Epub 2020 Jun 20.

Department of Neurosurgery, Centro Hospitalar Universitario do Algarve, Rua Leao Penedo, Faro, Portugal.

Background: A spontaneous cervical epidural hematoma (SCEH) is a rare occurrence. It usually presents with quadriparesis, but it may present with hemiparesis or hemiplegia and can easily be misdiagnosed as stroke. We present a case of stroke mimicking SCEH with hemiparesis worsened after tissue plasminogen activator therapy (tPA) followed by emergency cervical decompression laminectomy. Read More

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http://dx.doi.org/10.25259/SNI_161_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332487PMC

Risk of fatal sinus arrest induced by low-grade subarachnoid hemorrhage: A case of a young patient with obstructive sleep apnea.

Surg Neurol Int 2020 20;11:156. Epub 2020 Jun 20.

Department of Neurosurgery, Okinawa Miyako Hospital, Okinawa, Japan.

Background: Sleep apnea syndrome (SAS) and subarachnoid hemorrhage (SAH) are both considered possible causes of secondary arrhythmias. However, there are limited reports on the increased risk of bradyarrhythmia for arrhythmia-free SAS patients with SAH.

Case Description: A 31-year-old woman with SAS developed low-grade SAH and underwent coil embolization on postbleed day 1. Read More

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http://dx.doi.org/10.25259/SNI_66_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332489PMC

Report of intradural aneurysm in the cavernous segment of the internal carotid artery presented with subarachnoid hemorrhage and oculomotor palsy.

Surg Neurol Int 2020 13;11:149. Epub 2020 Jun 13.

Department of Neurosurgery, Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil.

Background: Aneurysms of the cavernous segment of the internal carotid artery (ICA) do not usually cause subarachnoid hemorrhage (SAH). We report a patient who presented with this condition due to a ruptured aneurysm located on the posterior genu of the cavernous segment, raising the question of what factors could have led to such evolution.

Case Description: A 55-year-old male patient presented with sudden, intense thunderstorm headache, associated with complete palsy of the left oculomotor nerve and neck stiffness. Read More

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http://dx.doi.org/10.25259/SNI_105_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332490PMC

Anterior temporal approach for clipping of ruptured basilar tip aneurysms: Surgical techniques and treatment outcomes.

Surg Neurol Int 2020 13;11:146. Epub 2020 Jun 13.

Department of Surgery, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.

Background: Basilar tip (BT) aneurysms are challenging to treat with microsurgical clipping, especially in subarachnoid hemorrhage cases. The anterior temporal approach is one of the surgical approaches for the treatment of aneurysms in this area. The majority of the previous reports on this approach have described unruptured cases. Read More

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http://dx.doi.org/10.25259/SNI_565_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332467PMC

Surgical management of submacular hemorrhage due to n-AMD: a comparison of three surgical methods.

Int J Retina Vitreous 2020 2;6:27. Epub 2020 Jul 2.

Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Background: To compare and assess the efficacy of three surgical methods for the treatment of acute submacular hemorrhage (ASH): pneumatic displacement with C2F6, in combination with intravitreal injection of bevacizumab and rtPA, pars plana vitrectomy (PPV) with intravitreal injection of gas (C2F6), bevacizumab and subretinal injection of recombinant tissue plasminogen activator (rtPA), pars plana vitrectomy (PPV) with intravitreal injection of gas (C2F6), bevacizumab and intravitreal injection of recombinant tissue plasminogen activator (rtPA).

Methods: The study included 85 patients with ASH. In the group without PPV (A), patients were treated with intravitreal injection of C2F6, bevacizumab and rtPA. Read More

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http://dx.doi.org/10.1186/s40942-020-00228-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331168PMC

Efficacy and safety of tranexamic acid administration in traumatic brain injury patients: a systematic review and meta-analysis.

J Intensive Care 2020 3;8:46. Epub 2020 Jul 3.

Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan.

Background: The exacerbation of intracranial bleeding is critical in traumatic brain injury (TBI) patients. Tranexamic acid (TXA) has been used to improve outcomes in TBI patient. However, the effectiveness of TXA treatment remains unclear. Read More

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http://dx.doi.org/10.1186/s40560-020-00460-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333334PMC

Haematological manifestations, mechanisms of thrombosis and anti-coagulation in COVID-19 disease: A review.

Ann Med Surg (Lond) 2020 Aug 30;56:173-177. Epub 2020 Jun 30.

Department of Haematology, Ampang Hospital, Jalan Mewah Utara, Pandan Mewah, 68000, Ampang, Selangor, Malaysia.

Coronavirus-19 disease (COVID-19), a zoonosis, was first reported in the city of Wuhan, province of Hubei, China in December 2019. The disease is caused by the Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2). As of 12 of May 2020, 4,256,022 confirmed cases affecting 212 countries with 287,332 deaths have been reported. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324342PMC

Combined thoracoabdomial injury: Case report.

Ann Med Surg (Lond) 2020 Aug 26;56:149-151. Epub 2020 Jun 26.

Osh State University, International Medical Faculty, Department of Anatomy, Histology and Normal Physiology, Jolon Mamytov Campus, 723500, Osh, Kyrgyzstan.

Introduction: Combined thoracoabdominal injuries are the most severe case in the medical practice. Bilateral injuries are rare case in patients and just few cases reported in literature. Diaphragm traumas and pneumothorax are defined as severe trauma leading to injuries of thoracic and abdominal organs. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330147PMC
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