481,452 results match your criteria Bleeding and Coagulation in Trauma[Journal]


[Off-pump Coronary Artery Bypass Grafting in Jehovah's Witness Patient on Hemodialysis;Report of a Case].

Kyobu Geka 2019 Feb;72(2):136-139

Department of Cardiovascular Surgery, Japanese Red Cross Asahikawa Hospital, Asahikawa, Japan.

Cardiac surgery in Jehovah's witnesses is challenging due to their refusal of blood transfusion. Furthermore, dialysis patients often suffer from anemia and are also prone to bleeding. We performed offpump coronary artery bypass grafting (CABG) [OPCAB] on a Jehovah's witness male patient on hemodialysis. Read More

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February 2019

[Endovascular Repair of Traumatic Injury to the Descending Aorta and the Right Subclavian Artery;Report of a Case].

Kyobu Geka 2019 Feb;72(2):128-131

Department of Cardiovascular Surgery, Japanese Red Cross Okayama Hospital, Okayama, Japan.

A 32-year-old man leaping down from the 3rd floor of his house got injured and was transferred to our center. Pseudoaneurysm at the aortic isthmus as well as pelvic and lower limb fractures were observed by computed tomography (CT) scan. Thoracic endovascular aortic repair(TEVAR)of the thoracic aorta was performed from zone 2, followed by external skeletal fixation. Read More

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February 2019

[Splenic Injury during Replacement of the Thoracoabdominal Aorta].

Kyobu Geka 2019 Feb;72(2):104-107

Division of Cardiovascular Surgery, Tohoku University, Sendai, Japan.

Extraperitoneal approach is commonly employed for thoracoabdominal aortic repair via Stoney incision. It is supposedly rare to encounter abdominal visceral bleeding during that procedure. However, the spleen may spontaneously adhere to the adjacent peritoneum, which could induce incidental injury to the spleen by its anterior mobilization during extraperitoneal approach. Read More

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February 2019

Novel use of tranexamic acid to reduce the need for Nasal Packing in Epistaxis (NoPac) randomised controlled trial: research protocol.

BMJ Open 2019 Feb 15;9(2):e026882. Epub 2019 Feb 15.

Research Design Service South West, Bristol, UK.

Introduction: Patients presenting to emergency departments (EDs) with epistaxis uncontrolled by subsequent simple first aid measures or application of topical vasoconstrictors will typically undergo anterior nasal packing. Packing is effective, but can be extremely painful and unpleasant and patients usually need hospital admission. Tranexamic acid (TXA) is a cheap, safe, readily available antifibrinolytic agent known to be beneficial in a variety of clinical settings where uncontrolled bleeding may be a problem. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026882DOI Listing
February 2019

PROFIT, a PROspective, randomised placebo controlled feasibility trial of Faecal mIcrobiota Transplantation in cirrhosis: study protocol for a single-blinded trial.

BMJ Open 2019 Feb 15;9(2):e023518. Epub 2019 Feb 15.

James Black Centre, School of Immunology & Microbial Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.

Introduction: Patients with advanced cirrhosis have enteric bacterial dysbiosis and translocation of bacteria and their products across the gut epithelial barrier. This culminates in systemic inflammation and endotoxaemia, inducing innate immune dysfunction which predisposes to infection, and development of complications such as bleeding, sepsis and hepatic encephalopathy. This feasibility study aims to assess the safety of administering faecal microbiota transplantion to patients with cirrhosis and explore the effect of the intervention on their prognosis by achieving restoration of a healthy gut microbiome. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023518DOI Listing
February 2019

Deep brain stimulation of the subthalamic nucleus in Parkinson's disease patients over 75 years of age.

J Neurol Sci 2019 Feb 11;399:57-60. Epub 2019 Feb 11.

Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.

Introduction: Deep brain stimulation (DBS) is an effective therapy for Parkinson's disease (PD). However, its effect in older patients is not extensively studied, as they are often excluded from DBS surgery due to concerns of complications or reduced benefit. We assessed clinical outcomes after subthalamic nucleus (STN) DBS in older patients (age > 75 years) with PD. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.019DOI Listing
February 2019

Comparison of 10-mg and 5-mg warfarin initiation nomograms in a South Indian population - An open label trial.

Thromb Res 2019 Jan 19;176:33-35. Epub 2019 Jan 19.

Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India.

Introduction: Early achievement of therapeutic INR leads to shorter hospital stay and lesser cost. Two warfarin initiation nomograms (10 mg nomogram and 5 mg nomogram) are widely used but it is not yet clear which one is better. They have been validated in the West but there are no studies from India. Read More

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http://dx.doi.org/10.1016/j.thromres.2018.12.026DOI Listing
January 2019

Use of Doppler Probe in Non-Variceal Upper-Gastrointestinal Bleeding is Less Costly and More Effective Than Standard of Care.

Clin Gastroenterol Hepatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Background & Aims: Upper gastrointestinal bleeding is a common emergency and rebleeding is associated with an increased risk of death. Proper assessment of high-risk lesions and appropriate endoscopic hemostasis are required for the best outcomes. The endoscopic Doppler probe exam (DPE) allows for a more complete assessment of the stigmata of hemorrhage, providing better evaluation of the need for endoscopic hemostasis and determination of its completeness. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.016DOI Listing
February 2019

Addition of Carvedilol to Gastric Variceal Obturation Does Not Decrease Recurrence of Gastric Variceal Bleeding in Patients With Cirrhosis.

Clin Gastroenterol Hepatol 2019 Feb 14. Epub 2019 Feb 14.

School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background & Aims: Gastric variceal bleeding (GVB) frequently recurs after hemostasis by gastric variceal obturation (GVO). We performed a multicenter, randomized controlled trial to determine the efficacy of carvedilol plus GVO in secondary prophylaxis of GVB.

Methods: We performed a prospective study of 121 patients with cirrhosis (ages 20-80 years) with GVB proven by endoscopy within 24 hours of bleeding and stable hemodynamics for at least 3 days after initial GVO. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.021DOI Listing
February 2019

Basilar occlusion and rupture secondary to rare fungal sinusitis: A case report.

World Neurosurg 2019 Feb 14. Epub 2019 Feb 14.

Lyerly Neurosurgery / Baptist Health, Baptist Neurological Institute, Jacksonville, FL.

Background: Intracranial vascular infections of fungal etiology are extremely rare. The vast majority of cases occur in immunocompromised patients with invasive fungal disease, most commonly originating in the paranasal sinuses or the lungs. An extremely rare type in this part of the world, called Granulomatous Invasive Rhinosinusitis, has been reported to affect immunocompetent patients in most cases, and its causative strain has potential to invade the intracranial arteries. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.179DOI Listing
February 2019

Delayed resolution of retinopathy of prematurity.

J AAPOS 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.

Purpose: To compare the characteristics of infants whose retinopathy of prematurity (ROP) resolves in <50 weeks with those of infants whose ROP resolves in >50 weeks' postmenstrual age (PMA) in order to identify which infants are at risk for delayed resolution and to evaluate whether severe ROP developed after 50 weeks' PMA.

Methods: The medical records of infants screened for ROP from January 2008 to December 2016 at a tertiary care facility were reviewed retrospectively. Infants without follow-up prior to ROP resolution or complete retinal vascularization and those with retinal detachment were excluded. Read More

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http://dx.doi.org/10.1016/j.jaapos.2018.10.012DOI Listing
February 2019

Combination of microneedles and microemulsions to increase celecoxib topical delivery for potential application in chemoprevention of breast cancer.

Int J Pharm 2019 Feb 14. Epub 2019 Feb 14.

Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil. Electronic address:

In spite of the high incidence of breast cancer worldwide, there are few strategies for its chemoprevention, and they have limited adherence mainly due to their serious adverse effects. As a new approach for local breast cancer chemoprevention, we developed and optimized microemulsions for topical delivery of celecoxib to the breast skin, and evaluated their combination with microneedles to improve drug penetration for localization in the mammary tissue. Microemulsions containing water at 15% (ME-15), 29% (ME-29) and 60% (ME-60) were obtained and characterized. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.011DOI Listing
February 2019

Dietary exposure to mycotoxin zearalenone (ZEA) during post-implantation adversely affects placental development in mice.

Reprod Toxicol 2019 Feb 14. Epub 2019 Feb 14.

Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, Georgia, USA. Electronic address:

Zearalenone (ZEA) is a common food contaminant (ppb˜ppm) derived from Fusarium fungi. With its estrogenicity and potential chronic exposure, ZEA poses a risk to pregnancy. Our previous studies implied post-implantational lethality by ZEA. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.010DOI Listing
February 2019

Heparin during endovascular stroke treatment seems safe Heparin during endovascular stroke treatment does not ameliorate clinical outcome and is associated with lower chance of reperfusion.

J Neuroradiol 2019 Feb 14. Epub 2019 Feb 14.

Comprehensive Stroke Center, Department of Systems Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. Electronic address:

Background And Purpose: the effect of intravenous heparin during mechanical thrombectomy for acute ischemic stroke is not clear. We aimed to study efficacy and safety of heparin use during endovascular stroke treatment in a real-world setting.

Materials And Methods: patients with anterior circulation stroke were divided, based on the use of intraprocedural heparin, in those treated and those untreated. Read More

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http://dx.doi.org/10.1016/j.neurad.2019.01.095DOI Listing
February 2019

Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease.

Gastroenterology 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, Pelvic Floor Unit, Aarhus University Hospital, Aarhus, Denmark.

Background And Aims: Perianal fistulas are common in patients with Crohn´s disease (CD). Injections of cultured autologous and allogeneic adipose tissue-derived stem cells have been shown to heal CD-associated fistulas. Unfortunately, this treatment is time-consuming and expensive. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.005DOI Listing
February 2019

Transcarotid Approach for Transcatheter Aortic Valve Replacement With the Sapien 3 Prosthesis: A Multicenter French Registry.

JACC Cardiovasc Interv 2019 Feb 7. Epub 2019 Feb 7.

Lille University Hospital, Lille, France. Electronic address:

Objectives: This study sought to describe the procedural and clinical outcomes of patients undergoing transcarotid (TC) transcatheter aortic valve replacement (TAVR) with the Edwards Sapien 3 device.

Background: The TC approach for TAVR holds the potential to become the optimal alternative to the transfemoral gold standard. Limited data exist regarding safety and efficacy of TC-TAVR using the Edwards Sapien 3 device. Read More

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http://dx.doi.org/10.1016/j.jcin.2018.11.014DOI Listing
February 2019

Blumgart's technique of pancreaticojejunostomy: Analysis of safety and outcomes.

Hepatobiliary Pancreat Dis Int 2019 Jan 31. Epub 2019 Jan 31.

Department of Surgical Gastroenterology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India. Electronic address:

Background: Blumgart's pancreaticojejunostomy (PJ) has been described with low pancreatic leak rates. This study aimed to evaluate our experience with this technique regarding the pancreatic leak and other perioperative outcomes.

Methods: We performed a single-center retrospective analysis of a cohort of 81 patients who underwent pancreaticoduodenectomy in our department from January 2011 to February 2018. Read More

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http://dx.doi.org/10.1016/j.hbpd.2019.01.007DOI Listing
January 2019

Characteristics Associated With Mortality in 372 Patients Receiving Low-Dose Recombinant Factor VIIa (rFVIIa) for Cardiac Surgical Bleeding.

J Cardiothorac Vasc Anesth 2019 Jan 22. Epub 2019 Jan 22.

Department of Anesthesiology, Division of Critical Care, Kansas University Medical Center, Kansas City, KS. Electronic address:

Objective: Activated recombinant factor VII (rFVIIa) has been used to treat cardiac surgical bleeding in an off-label manner. This observational report analyzes the outcomes with use of a low dose and early administration of rFVIIa for cardiac surgical bleeding.

Design: A retrospective, observational study. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.047DOI Listing
January 2019

Prevalence and Clinical Impact of Systemic Inflammatory Reaction After Cardiac Surgery.

J Cardiothorac Vasc Anesth 2019 Jan 17. Epub 2019 Jan 17.

Department of Emergency and Organ Transplant, University of Bari Aldo Moro, Italy; Santa Maria Hospital, Department of Cardiac Surgery, GVM Care & Research, Bari, Italy. Electronic address:

Objectives: Cardiac surgery induces a systemic inflammatory reaction that has been associated with postoperative mortality and morbidity. Many studies have characterized this reaction through laboratory biomarkers while clinical studies generally are lacking. This study aimed to assess the incidence of postoperative systemic inflammation after cardiac surgery, and the association of postoperative systemic inflammation with preoperative patients' characteristics and postoperative outcomes. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.043DOI Listing
January 2019

Efficacy of Direct Revascularization Surgery for Hemorrhagic Moyamoya Syndrome As a Late Complication of Cranial Irradiation for Childhood Craniopharyngioma.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Tohoku University, Sendai, Japan.

Moyamoya syndrome (MMS) is an uncommon late complication after cranial irradiation. Its hemorrhagic presentation from the associated pseudo-aneurysm is extremely rare, and the optimal management strategy is undetermined. We herein report a 36-year-old man who developed intraventricular hemorrhage from a pseudo-aneurysm at the extended left anterior choroidal artery as an abnormal collateral of MMS 30 years after surgical removal and cranial irradiation for childhood craniopharyngioma. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.033DOI Listing
February 2019

Direct Aspiration versus Stent Retriever Thrombectomy for Acute Stroke: A Systematic Review and Meta-Analysis in 9127 Patients.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, University of South Florida, Tampa, Florida. Electronic address:

Background: The two most common approaches to thrombectomy of emergent large vessel occlusion (direct aspiration and primary stent retriever thrombectomy) have been extensively studied; however, the detailed benefit and risk comparison is largely unknown.

Objective: To conduct a systematic review and meta-analysis to compare radiographic and clinical outcomes between the use of primary stent retrievers and direct aspiration in management of acute ischemic stroke.

Methods: PubMed database was searched for studies between September 1, 2012 and December 31, 2017 with acute ischemic stroke patients. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.034DOI Listing
February 2019

Endoscopic band ligation - A valid option in colonic diverticular bleeding.

Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Gastroenterology, CHLN - Hospital de Santa Maria, Portugal.

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http://dx.doi.org/10.1016/j.gastrohep.2018.11.006DOI Listing
February 2019

Anticoagulation for atrial fibrillation in patients with active cancer.

Int J Cardiol 2019 Apr;280:98

Lymphoid Malignancies Branch, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.ijcard.2018.11.003DOI Listing

Mechanical thrombectomy of M2 occlusions with distal access catheters using ADAPT.

J Neuroradiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Diagnostic and Interventional Neuroradiology, Medical School Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany; Department of Interventional Neuroradiology, Johanna-Etienne-Hospital, Am Hasenberg 46, D-41462 Neuss, Germany.

Background And Purpose: The direct aspiration first pass technique (ADAPT) using distal access catheters (DAC) has proven to be an effective and safe endovascular treatment strategy of acute ischemic stroke with large vessel occlusions (LVO). However, data about direct aspiration using DAC in M2 segment occlusions is limited. We assess the safety and efficacy of DACs in acute M2 occlusions using ADAPT with large bore (5 French /6 French) aspiration catheters as the primary method for endovascular recanalization. Read More

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http://dx.doi.org/10.1016/j.neurad.2019.01.096DOI Listing
February 2019

Development and Validation of a Risk-Calculator for Adverse Perioperative Outcomes for Women with Ovarian Cancer.

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Columbia University College of Physicians and Surgeons; Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons; New York Presbyterian Hospital. Electronic address:

Background: Primary cytoreduction followed by platinum based chemotherapy is the primary treatment for advanced ovarian cancer. However neoadjuvant chemotherapy followed by interval debulking is an alternative option, particularly in those who may be poor surgical candidates.

Objective: The objective of this study was to determine factors associated with short term, significant perioperative morbidity and mortality for women undergoing surgery for ovarian cancer and to create a nomogram to predict the risk of adverse perioperative outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029378193036
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http://dx.doi.org/10.1016/j.ajog.2019.02.019DOI Listing
February 2019
3 Reads

Determination of serum neutrophil gelatinase-associated lipocalin as a prognostic biomarker of acute spontaneous intracerebral hemorrhage.

Clin Chim Acta 2019 Feb 13. Epub 2019 Feb 13.

Department of Emergency Intensive Care Unit, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, 108 Wansong Road, Ruian 325200, Zhejiang Province, China.

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is currently known as an acute phase protein and implicated in acute brain injury. Herein, we sought to gauge serum NGAL level in patients after acute (<24 h) spontaneous intracerebral hemorrhage (ICH) and to investigate its relation to neurological outcome.

Methods: Serum NGAL levels were measured in 106 patients and 106 controls. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.009DOI Listing
February 2019

The importance of non-technical performance for teams managing postpartum haemorrhage: video review of 99 obstetric teams.

BJOG 2019 Feb 16. Epub 2019 Feb 16.

School of Applied Psychology, University of Applied Sciences and Arts Northwestern Switzerland, Switzerland.

Objective: Little is known about how teams' non-technical performance influences clinical performance in obstetric emergencies like postpartum haemorrhage.

Design: Video review - observational study.

Setting: A university hospital (5,000 deliveries) and a regional hospital (2,000 deliveries) in Denmark. Read More

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http://dx.doi.org/10.1111/1471-0528.15655DOI Listing
February 2019

Intracameral Phenylephrine to Arrest Intraoperative Intraocular Bleeding: A New Technique.

Ophthalmol Ther 2019 Feb 15. Epub 2019 Feb 15.

The Western Eye Hospital, Imperial College NHS Trust, London, UK.

Intraoperative intraocular bleeding can present a major challenge during anterior segment operations, such as cataract and glaucoma surgery. In the presence of significant intraocular bleeding, the surgeon may be unable to proceed if the bleeding cannot be controlled. Uncontrolled bleeding may also result in intraoperative or postoperative complications. Read More

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http://dx.doi.org/10.1007/s40123-019-0165-yDOI Listing
February 2019

Preliminary report of microwave ablation for the primary papillary thyroid microcarcinoma: a large-cohort of 185 patients feasibility study.

Endocrine 2019 Feb 15. Epub 2019 Feb 15.

Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130000, China.

Purpose: To assess the safety and efficacy of microwave ablation (MWA) for primary papillary thyroid microcarcinoma (PTMC) with a large sample of 185 patients.

Methods: A total of 185 patients underwent MWA for 206 primary PTMC nodules. They received ultrasound follow-up at 1, 3, 6, and 12 months after MWA and every 6 months thereafter. Read More

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http://dx.doi.org/10.1007/s12020-019-01868-2DOI Listing
February 2019

Frailty score for elderly patients is associated with short-term clinical outcomes in patients with ST-segment elevated myocardial infarction treated with primary percutaneous coronary intervention.

Neth Heart J 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands.

Objective: Consistent with the aging population in the Western world, there is a growing number of elderly patients with ST-segment elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention (PCI) is the recommended reperfusion strategy in elderly patients; risk models to determine which of these patients are prone to have poor clinical outcomes are, however, essential. The purpose of this study was to assess the association between frailty and short-term mortality and PCI-related serious adverse events (SAE) in elderly patients. Read More

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http://dx.doi.org/10.1007/s12471-019-1240-7DOI Listing
February 2019

Stomaching Acute Brain Injury.

Neurocrit Care 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Gastrointestinal complications, including hemorrhage, can occur with intracranial lesions and after craniotomy. As early as the 19th century, surgeons were aware that brain tumors could cause gastric ulcers and acute perforations. Investigators used animal experiments both to reproduce these clinical observations and to seek ways to block the effects. Read More

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http://dx.doi.org/10.1007/s12028-019-00685-9DOI Listing
February 2019

Uptake in antithrombotic treatment and its association with stroke incidence in atrial fibrillation: insights from a large German claims database.

Clin Res Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiology, Ludwig-Maximilians-University, Munich, Germany.

Background: Underuse of oral anticoagulation (OAC) for stroke prevention in atrial fibrillation (AF) results in thousands of preventable strokes in Germany each year. This study aimed to assess changes in antithrombotic therapy in AF patients after increased use of direct oral anticoagulants (DOACs) in Germany and to evaluate whether the adoption of DOAC therapy was associated with changes in AF-related stroke and bleeding over time.

Methods: Analyses were carried out on a large claims-based dataset of 4 million health-insured Germans. Read More

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http://dx.doi.org/10.1007/s00392-019-01437-7DOI Listing
February 2019

Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population.

Clin Oral Investig 2019 Feb 15. Epub 2019 Feb 15.

Department of Periodontal Medicine, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.

Objectives: Periodontal inflammation is regarded as a risk factor for drug-induced gingival overgrowth (DIGO). In order to elucidate the involvement of periodontal inflammation in DIGO, the periodontal status of subjects who do not develop DIGO despite receiving causative drugs (non-responders) needs to be examined. Therefore, the aim of the present study which was a pilot study was to assess periodontal inflammatory variables in responders (calcium channel blocker induced-GO patients), non-responders, and patients who did not receive causative drugs (non-consumers). Read More

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http://dx.doi.org/10.1007/s00784-019-02846-8DOI Listing
February 2019
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Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Medical and Surgical Research Unit, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO removal while potentially reducing the risk of ventilator-induced lung injury.

Objective: To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.

Study Design: Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO). Read More

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http://dx.doi.org/10.1038/s41372-019-0338-5DOI Listing
February 2019

Dual antithrombotic therapy in PCI: Potential harm in routine adoption.

Catheter Cardiovasc Interv 2019 Feb;93(3):E185-E186

Division of Cardiology, Rhode Island Hospital, Warren Alpert Medical School at Brown University, Providence, Rhode Island.

Randomized clinical trials support the use of dual antithrombotic therapy (DAT) in PCI patients but outcomes in clinical practice are unclear. In this observational study of patients at high risk for thromboembolism and bleeding, routine use of a P2Y12 inhibitor alone compared with DAPT with OAC was associated with a significantly higher risk of ischemic events without a lower risk of bleeding. Future randomized trials and observational analyses of large registries are needed to select the ideal patient population for DAT. Read More

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http://dx.doi.org/10.1002/ccd.27999DOI Listing
February 2019

Roadmap for the radial: Should we stop for directions?

Catheter Cardiovasc Interv 2019 Feb;93(3):E195-E196

MS Hershey Medical Center, College of Medicine, Heart & Vascular Institute, Penn State University, Hershey, PA.

Regimented use of radial artery angiography prior to ST-segment myocardial infarction (STEMI) intervention may improve complication rates and can be associated with improved procedural success, procedural time, and reduction in access-site bleeding. Routine radial artery angiography may improve procedural quality without increase in procedural time or contrast use. Regardless of whether universal or selective radial angiography is best practice, angiography is an important tool to use for efficient radial access. Read More

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http://dx.doi.org/10.1002/ccd.28058DOI Listing
February 2019

HAS-BLED for predicting transfemoral transcatheter aortic valve replacement outcomes: Enough to tamponade the problem?

Catheter Cardiovasc Interv 2019 Feb;93(3):E202-E203

Division of Cardiology, Department of Medicine, Regional Heart Center, University of Washington, Seattle, Washington.

As indications for TAVR expand, there is a need for predictive models of procedural complications. Application of the HAS-BLED score demonstrated patient comorbidities that contribute to increased bleeding events and mortality. Further adequately powered studies will be needed to validate the HAS-BLED score for use in the TAVR population or further elucidate important risk factor to incorporate into future predictive risk models. Read More

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http://dx.doi.org/10.1002/ccd.28004DOI Listing
February 2019

The p35/CDK5 signaling is regulated by p75NTR in neuronal apoptosis after intracerebral hemorrhage.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People's Republic of China.

The p75 neurotrophin receptor (p75NTR), a member of tumor necrosis factor receptor superfamily, involves in neuronal apoptosis after intracerebral hemorrhage (ICH). It has been previously demonstrated that phosphorylation of p35 is a crucial factor for fighting against the proapoptotic p25/CDK5 signaling in neuronal apoptosis. Then, in ICH models of rats and primary cortical neurons, we found that the expressions of p75NTR, p-histone H1 (the kinase activity of CDK5), p25, Fas-associated phosphatase-1 (FAP-1), and phosphorylated myocyte enhancer factor 2D (p-MEF2D) were enhanced after ICH, whereas the expression of p35-Thr(138) was attenuated. Read More

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http://dx.doi.org/10.1002/jcp.28244DOI Listing
February 2019

Acute Non-Traumatic Spontaneous Auricular Hematoma.

Am J Case Rep 2019 Feb 16;20:204-206. Epub 2019 Feb 16.

Department of Emergency Medicine, Mayo Clinic, Jacksonville, FL, USA.

BACKGROUND Auricular hematomas are well-known among wrestlers and other contact sports participants, but spontaneous auricular hematomas are rare. The differential diagnosis for acute spontaneous auricular swelling is limited. In addition to infectious causes, antecedent trauma, and bleeding complications, angioedema should also be considered. Read More

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http://dx.doi.org/10.12659/AJCR.913464DOI Listing
February 2019

Thermal cautery-assisted circumcision and principles of its use to decrease complication rates.

J Pediatr Urol 2019 Jan 19. Epub 2019 Jan 19.

Medicine Hospital Department of Urology, Biruni University, İstanbul, Turkey.

Introduction: Circumcision is one of the most frequently applied surgical procedures all over the world and a number of techniques and devices have been described concerning its method. Especially in developing countries where circumcision has been performed intensively under local anaesthesia, the thermocautery device developed to perform circumcisions in a short time and safely has found a widespread application.

Objective: We aim to share our experiences concerning application principles of the thermocautery device so as to be able to achieve better cosmetic results with lower complication rates. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.01.003DOI Listing
January 2019

Prognostic factors in patients with active non-variceal upper gastrointestinal bleeding.

Arab J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address:

Background And Study Aims: Acute upper gastrointestinal bleeding is one of the main causes of hospitalisation. The purpose of this study was to determine the prognostic factors in non-variceal upper gastrointestinal bleeding.

Patients And Methods: Clinical outcomes, demographic and laboratory variables of the subjects were collected from the HIS software and national code with the SQL format from three hospitals in Qazvin. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.01.001DOI Listing
February 2019

Non-vitamin K antagonist oral anticoagulants with amiodarone, P-glycoprotein inhibitors, or polypharmacy in patients with atrial fibrillation: Systematic review and meta-analysis.

J Cardiol 2019 Feb 12. Epub 2019 Feb 12.

Yonsei University Health System, Seoul, Republic of Korea. Electronic address:

Background: Amiodarone, which inhibits CYP2C9 and P-glycoprotein, is commonly prescribed with non-vitamin K antagonist oral anticoagulants (NOACs) and polypharmacy in high-risk atrial fibrillation (AF) patients. We studied efficacy and safety of NOACs in AF patients receiving amiodarone, P-glycoprotein inhibitor, or polypharmacy.

Methods: After a systematic database search (Medline, EMBASE, CENTRAL, SCOPUS, and Web of Science), four phase-III randomized trials comparing NOACs and warfarin in "with/without amiodarone," "with/without P-glycoprotein inhibitors," or "with/without multiple (≥5, polypharmacy) concomitant drugs" subgroups were included. Read More

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http://dx.doi.org/10.1016/j.jjcc.2018.12.018DOI Listing
February 2019

A tumor board report of an 83-year-old woman with stage IB grade 3 endometrioid endometrial adenocarcinoma.

Curr Probl Cancer 2019 Feb 7. Epub 2019 Feb 7.

Brigham and Women's Hospital, Department of Gynecologic Oncology, Boston, Massachusetts; Dana Farber Cancer Institute, Department of Gynecologic Oncology, Boston, Massachusetts.

An 83-year-old woman presented with postmenopausal bleeding ultimately leading to surgery and a final diagnosis of stage IB grade 3 endometrioid endometrial adenocarcinoma. The tumor board reviewed current literature regarding the efficacy of sentinel lymph node dissection in appropriately allocating stage in high-grade endometrial cancer. The optimal role of adjuvant treatment in this setting is unclear. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2019.01.006DOI Listing
February 2019

Centrifugal-flow ventricular assist device support in children: A single-center experience.

J Thorac Cardiovasc Surg 2018 Dec 27. Epub 2018 Dec 27.

Congenital Heart Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Tex.

Background: Our institutional policy is to continue centrifugal-flow ventricular assist device support for 3 months or more without activation on the transplant wait-list for physical recovery and assessment of possible myocardial recovery. We evaluated our single-institutional outcomes with centrifugal-flow ventricular assist device support in children.

Methods: Prospectively collected outcomes data in consecutive patients aged 18 years or less with centrifugal-flow ventricular assist device support were reviewed. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.12.045DOI Listing
December 2018

Effect of Perioperative Antiplatelet Therapy on Outcomes in Patients With Drug-Eluting Stents Undergoing Elective Noncardiac Surgery.

Am J Cardiol 2019 Feb 7. Epub 2019 Feb 7.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Korea.

We investigated the association of perioperative antiplatelet therapy (APT) and outcomes in patients with drug-eluting stent (DES) placement for noncardiac surgery (NCS). In consecutive 23,358 patients who underwent percutaneous coronary interventions between 2005 and 2016, total of 2,179 patients that required 2,179 elective NCS after DES placement were retrospectively analyzed. A net adverse clinical event (NACE), composite of death, myocardial infarction, stent thrombosis, and major bleeding, was assessed at 30 days. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.004DOI Listing
February 2019

[Rendu-Osler disease and recurrent thromboembolic venous disease].

J Med Vasc 2019 Feb 12;44(1):76-78. Epub 2018 Dec 12.

Service de médecine interne, CHU Hédi Chaker, Sfax, Tunisie.

Rendu-Osler-Weber syndrome is a rare systemic fibrovascular dysplasia, recognized by mucocutaneous telangiectasias, arteriovenous malformations, epistaxis and family history. Venous thromboembolic disease is a poor prognostic factor in this disease given the risk of increased bleeding caused by anticoagulant therapy. We report a new case of a 56-year-old patient with Osler disease who developed recurrent thromboembolic venous disease when anticoagulants were discontinued. Read More

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http://dx.doi.org/10.1016/j.jdmv.2018.11.003DOI Listing
February 2019

One-year clinical outcomes of ticagrelor compared with clopidogrel after percutaneous coronary intervention in patients with acute myocardial infarction: From Korean Health Insurance Review and Assessment Data.

J Cardiol 2019 Mar;73(3):191-197

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Ticagrelor has been widely accepted in clinical practice for treatment of acute myocardial infarction (AMI), however its clinical safety and efficacy have not been revealed sufficiently in Asian populations.

Methods And Results: Among a total 20,270 patients (age <75 years) with AMI undergoing percutaneous coronary intervention who received dual antiplatelet therapy for at least 30 days, clinical outcomes at 1 year were assessed from the database of Health Insurance Review and Assessment Service in Korea between 2013 and 2014. Ticagrelor showed a significant effect on reduction of all-cause death [stabilized inverse probability of treatment weighted (sIPTW)-adjusted odds ratio (aOR) 0. Read More

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http://dx.doi.org/10.1016/j.jjcc.2018.08.005DOI Listing