485,298 results match your criteria Bleeding and Coagulation in Trauma[Journal]


Evidence for resumption of anticoagulation after a previous major gastrointestinal bleeding.

Authors:
Marc Sorigue

Thromb Res 2019 Apr 12;178:99-100. Epub 2019 Apr 12.

Department of Hematology, ICO-Hospital Germans Trias i Pujol, Institut de Recerca Josep Carreras, Universitat Autònoma de Barcelona, Badalona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2019.04.012DOI Listing

Dose reduction of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: A Danish nationwide cohort study.

Thromb Res 2019 Apr 9;178:101-109. Epub 2019 Apr 9.

Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Kildegaardsvej 28, 2900 Hellerup, Denmark.

Introduction: To investigate the patterns of dose reduction of non-vitamin K antagonist oral anticoagulants (NOAC) in patients with atrial fibrillation (AF).

Materials And Methods: Using Danish nationwide registries, we identified all non-valvular AF patients initiated on standard-dose NOAC during 2011-2017 who were followed until dose reduction. The absolute risk of dose reduction was presented as cumulative incidence both overall and according to baseline characteristics. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.04.007DOI Listing

Integrating Bleeding Control Training Into Surgical Missions in Low- and Middle-Income Countries.

J Surg Res 2019 Apr 17;241:53-56. Epub 2019 Apr 17.

Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.

Background: Basic bleeding control (BCon) techniques can save lives globally but the knowledge is not widespread in low-income countries where trauma is a common cause of death. Short-term surgical missions (STSMs) are an effective route to share this public health initiative around the world.

Materials And Methods: Over 2017-2018, the International Surgical Health Initiative organized STSMs to locations in Sierra Leone, Bangladesh, Peru, and Ghana. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.020DOI Listing

Off-pump bilateral lung transplantation via median sternotomy: a novel approach with potential benefits.

Ann Thorac Surg 2019 Apr 17. Epub 2019 Apr 17.

Cardiothoracic Services, Freeman Hospital, Newcastle upon Tyne, United Kingdom. Electronic address:

The clamshell incision is worldwide the standard approach for bilateral lung transplantation. There is very limited experience with bilateral lung transplantation via median sternotomy so far and the use of cardiopulmonary bypass seems to be mandatory in all these cases accepting the potential disadvantages of the extracorporeal circulation. We describe a novel approach for bilateral lung transplantation as off-pump technique via median sternotomy which has the potential to combine the advantages of median sternotomy with less postoperative pain and better chest wall function and off-pump technique with reduced risk of primary graft dysfunction and bleeding complications. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.055DOI Listing

Influence of rifampin-mediated OATP1B1/1B3 inhibition on the pharmacokinetics of clazosentan.

Clin Transl Sci 2019 Apr 20. Epub 2019 Apr 20.

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.

Clazosentan is a selective endothelin A receptor antagonist in development for prevention and treatment of vasospasm post subarachnoid hemorrhage. It is a substrate of organic-anion-transporting polypeptide (OATP)1B1/1B3 based on preclinical data. This randomized, double-blind, two-period cross-over study investigated the pharmacokinetics, safety, and tolerability of an intravenous (i. Read More

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http://dx.doi.org/10.1111/cts.12639DOI Listing

Intramedullary Nail Fixation Assisted by Orthopaedic Robot Navigation for Intertrochanteric Fractures in Elderly Patients.

Orthop Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Orthopaedics, Pidu District People's Hospital, Chengdu.

Objective: To compare the clinical efficacy of intramedullary nail fixation for intertrochanteric fractures assisted by orthopaedic robot navigation and the traditional intramedullary nail fixation in elderly patients, and to investigate the application advantages of intramedullary nail fixation for femoral intertrochanteric fractures assisted by orthopaedic robot navigation in the elderly.

Methods: Among the 51 patients with intertrochanteric fractures who were selected from April 2015 to September 2017 in the Affiliated Hospital of Chengdu University, 25 patients underwent the intramedullary nail fixation assisted by orthopaedic robot navigation (orthopaedic robot navigation surgery group) and 26 patients underwent the traditional intramedullary nail fixation (traditional surgery group). The operation time, the number of intraoperative fluoroscopy images taken, the frequency of guide pins inserted into the femoral marrow cavity, the amount of intraoperative bleeding, and the one-time success rate of the guide pin inserted into the femoral marrow cavity were recorded. Read More

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http://dx.doi.org/10.1111/os.12447DOI Listing

Unexpected conversion to thoracotomy during thoracoscopic lobectomy: a single-center analysis.

Gen Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Istinye University Medical Faculty, Liv Hospital Ulus, Istanbul, Turkey.

Background: The aim of this study was to discuss indications and outcomes for conversion to thoracotomy during thoracoscopic lobectomy.

Materials And Methods: Patients who underwent lobectomy for non-small cell lung cancer between January 2012 and December 2016 were evaluated retrospectively. The study included 129 patients who underwent video-assisted thoracoscopic lobectomy (group-V) and 18 patients converted from thoracoscopic lobectomy to thoracotomy due to unexpected intraoperative complications (group-T). Read More

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http://link.springer.com/10.1007/s11748-019-01127-1
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http://dx.doi.org/10.1007/s11748-019-01127-1DOI Listing
April 2019
1 Read

De-escalation from ticagrelor to clopidogrel in acute coronary syndrome patients: a systematic review and meta-analysis.

J Thromb Thrombolysis 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, LMU München, Marchioninistraße 15, 81377, Munich, Germany.

De-escalation from ticagrelor to clopidogrel in acute coronary syndrome (ACS) may occur for a variety of reasons, including side effects (bleeding and non-bleeding) and costs. This study sought to assess the prevalence of de-escalation from ticagrelor to clopidogrel and the occurrence of adverse clinical outcomes following de-escalation. We conducted a systematic review of clinical trials and real-world studies in ACS patients treated with ticagrelor. Read More

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http://link.springer.com/10.1007/s11239-019-01860-7
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http://dx.doi.org/10.1007/s11239-019-01860-7DOI Listing
April 2019
1 Read

Acquired Von Willebrand Syndrome (AVWS) in cardiovascular disease: a state of the art review for clinicians.

J Thromb Thrombolysis 2019 Apr 19. Epub 2019 Apr 19.

Stonehill Professor of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, CVC 4th Floor, Room 4936, Cincinnati, 45267, OH, USA.

Von Willebrand Factor (vWF) is a large glycoprotein with a broad range of physiological and pathological functions in health and disease. While vWF is critical for normal hemostasis, vascular integrity and repair, quantitative and qualitative abnormalities in the molecule can predispose to serious bleeding and thrombosis. The heritable form of von Willebrand Disease was first described nearly a century ago, but more recently, recognition of an acquired condition known as acquired von Willebrand Syndrome (AVWF) has emerged in persons with hematological, endocrine and cardiovascular diseases, disorders and conditions. Read More

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http://dx.doi.org/10.1007/s11239-019-01849-2DOI Listing

Safety and Efficacy of 0.5% Carbomer 980 Gel for Treatment of Symptoms of Common Cold: Results of 2 Randomized Trials.

Authors:
Lara Dennie

Drugs R D 2019 Apr 19. Epub 2019 Apr 19.

Clinical Research Innovation, GlaxoSmithKline Consumer Healthcare, 184 Liberty Corner Rd, Warren, NJ, 07059, USA.

Background: Two studies of intranasal 0.5% carbomer 980 gel were conducted evaluating nasal tolerability in healthy volunteers and safety and efficacy in adults with common cold symptoms.

Methods: Study 1 randomly assigned healthy adults to 0. Read More

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http://dx.doi.org/10.1007/s40268-019-0270-3DOI Listing

Adherence to Long-Term Follow-Up of Patients with Life-Threatening, Inhaled Synthetic Cannabinoids-Associated Coagulopathy in Chicago.

Lung 2019 Apr 19. Epub 2019 Apr 19.

Division of Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Medicine (M/C 719), University of Illinois at Chicago, 840 South Wood Street, Chicago, IL, 60612, USA.

A large-scale outbreak of life-threatening, inhaled synthetic cannabinoids (Spice/K2)-associated coagulopathy with bleeding complications was recently reported in Illinois. The causative agents were brodifacoum, difenacoum, and bromadiolone, potent, long-acting, 4-hydroxycoumarin anticoagulant rodenticides (LAAR) that were mixed with Spice/K2 products procured and then inhaled by the victims. We report on 3 poisoned patients who reside in underserved, socioeconomically disadvantaged neighborhoods of Chicago that were admitted and treated successfully at two inner-city, tertiary care hospitals in Chicago. Read More

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http://dx.doi.org/10.1007/s00408-019-00227-2DOI Listing

MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Department of Neurology (J.M.-F., L.P.-S., R.M., R.D.-M., A.M.-D., P.C.-R., E.J.-X.) and Epidemiology (I.G.), Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, Barcelona; Departments of Radiology (S.M.-M.) and Neurology (A.R.-C.), Hospital del Mar-Parc de Salut Mar, Barcelona; Unitat RM IDI (E.M.) and Department of Neurosciences (M.H.-P.), Hospital Germans Trias i Pujol, Badalona; Department of Neurology (M.Z.), Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy; Department of Neurology (M.G.-C.), Hospital de Sant Joan Despí Moises Broggi, Sant Joan Despí, Spain; Department of Neurology (L. Lara), Hospital de León; Department of Neurology (A.B.), Hospital Universitari Son Espases, Palma de Mallorca; Department of Neurology (A.C.), Hospital de Valladolid; Department of Neurology (A.M.D.A.-B.), Hospital de Donostia; Department of Neurology (Y.B.), Hospital de Burgos; Department of Neurology (B.F.), Hospital Universitario La Paz, Universidad Autónoma de Madrid, Instituto de Investigación IdiPaz, Madrid; Department of Neurology (D. Cánovas), Hospital Parc Taulí, Sabadell; Department of Neurology (L. Llull), Hospital Clínic, Barcelona; Department of Neurology (B.Z.), Hospital de Navarra, Pamplona; Department of Neurology (M.F.), Hospital de Basurto, Bilbao; Department of Neurology (I.C.-N.), Hospital San Pedro de Alcántara, Cáceres; Department of Neurology (J.S.), Hospital Arnau de Vilanova, Lleida; Department of Neurology (D. Cocho), Hospital de Granollers; Department of Neurology (J.K.), F.Ass. Mutua Terrassa; Department of Neurology (E.P.), Hospital de Mataró; Department of Neurology (A.D.F.), Hospital Ramón y Cajal, Madrid; Department of Neurology (M.S.), Hospital La Rioja, Logroño; Department of Neurology (E.Z.-A.), Hospital Virgen del Rocío, Sevilla; Department of Neurology (J.Z.-B.), Hospital Verge de la Cinta, Tortosa; Department of Neurology (I.D.-M.), Hospital de Albacete; Department of Neurology (J.F.-D.), Centro Médico Asturias, Oviedo; Department of Neurology (A.L.), Hospital La Fe, Valencia; Department of Neurology (J.M.), Hospital Virgen de las Nieves, Granada; and Department of Neurology (M.R.-Y.), Hospital Santiago de Compostela, Santiago de Compostela, Spain.

Objective: We tested the hypothesis that the risk of intracranial hemorrhage (ICH) in patients with cardioembolic ischemic stroke who are treated with oral anticoagulants (OAs) can be predicted by evaluating surrogate markers of hemorrhagic-prone cerebral angiopathies using a baseline MRI.

Methods: Patients were participants in a multicenter and prospective observational study. They were older than 64 years, had a recent cardioembolic ischemic stroke, and were new users of OAs. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007532DOI Listing
April 2019
3 Reads

Optimal dilation time for combined small endoscopic sphincterotomy and balloon dilation for common bile duct stones: a multicentre, single-blinded, randomised controlled trial.

Lancet Gastroenterol Hepatol 2019 Apr 16. Epub 2019 Apr 16.

Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China; Hepatopancreatobiliary Surgery Institute of Gansu Province, Clinical Medical College Cancer Center of Lanzhou University, Lanzhou, China; Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province, Lanzhou, China. Electronic address:

Background: Endoscopic sphincterotomy is the established treatment for common bile duct stones. Balloon dilation offers an alternative. Prolonged dilation (300 s) with a 10 mm diameter balloon decreases the occurrence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). Read More

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http://dx.doi.org/10.1016/S2468-1253(19)30075-5DOI Listing

Pregnancy after Superselective Embolization of the Cervicovaginal Arteries for a Bleeding Cervical Fibroid.

J Vasc Interv Radiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Hackensack University Medical Center, 30 Prospect Avenue, Hackensack, NJ 07601.

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http://dx.doi.org/10.1016/j.jvir.2018.09.036DOI Listing

Extrahepatic Clinical Application of Vessel Tracking Software and 3D Roadmapping Tools: Preliminary Experience.

J Vasc Interv Radiol 2019 Apr 17. Epub 2019 Apr 17.

Division of Interventional Radiology, Department of Radiology, New York-Presbyterian Hospital/Weill Cornell Medical Center, 525 East 68th Street, P-518, New York, New York 10065. Electronic address:

This article demonstrates the use of a representative commercially available automated vessel-tracking software originally intended for liver-only application (Vessel Assist Flight Plan for Liver; GE) in 4 patients. Treatment settings included embolization of small bowel hemorrhage source, treatment of renal cell carcinoma, management of symptomatic benign prostate hypertrophy, and detection with subsequent closure of a mesenteric pseudoaneurysm. All patients were treated successfully. Read More

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http://dx.doi.org/10.1016/j.jvir.2018.11.039DOI Listing

Kasabach-Merritt syndrome arising from a vascular fistula.

Am J Emerg Med 2019 Apr 10. Epub 2019 Apr 10.

Internal Medicine, San Camillo Hospital, Rome, Italy.

A 58-year-old woman presented with gum bleeding, hematuria, and cutaneous ecchymoses. Left hip replacement had been performed five years prior. The overall findings of our work-up were consistent with ongoing DIC triggered by the presence of an arterio-venous left femoral fistula. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07356757193023
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http://dx.doi.org/10.1016/j.ajem.2019.04.013DOI Listing
April 2019
1 Read

Examiner Position in Ocular Point-of-Care Ultrasound: A Proposed Technique.

J Emerg Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Background: Ocular point-of-care ultrasound (POCUS) is a fast and safe non-invasive procedure used to evaluate the structural integrity and pathology of the eye. Ocular POCUS can be used for evaluation of posterior chamber and orbital pathology, including retinal detachment, vitreous detachment or hemorrhage, foreign body, lens dislocation, and increased intracranial pressure.

Discussion: The purpose of this brief communication is to describe a technique for conducting an ocular POCUS that may in some cases be easier and more comfortable by adjusting the position of the sonographer relative to the patient. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679193023
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http://dx.doi.org/10.1016/j.jemermed.2019.03.027DOI Listing
April 2019
1 Read

Inflammation during acute coronary syndromes - Risk of cardiovascular events and bleeding.

Int J Cardiol 2019 Mar 27. Epub 2019 Mar 27.

Department of Cardiology, University Heart Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

Background: Many parameters can affect the level of inflammation during acute coronary syndromes (ACS). We aimed to assess the one-year risk of major adverse cardiovascular events (MACE) and bleeding associated with elevated hsCRP levels during ACS, taking into account the severity of myocardial infarction, the timing of blood sampling and established long-term prognostic factors.

Methods: We studied 1864 consecutive patients with ACS enrolled in a contemporary multicenter prospective cohort study in Switzerland. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.03.049DOI Listing
March 2019
2 Reads

Impact of spontaneous rupture on the survival outcomes after liver resection for hepatocellular carcinoma: A propensity matched analysis comparing ruptured versus non-ruptured tumors.

Eur J Surg Oncol 2019 Apr 9. Epub 2019 Apr 9.

Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore; Duke-National University of Singapore (NUS) Medical School, Singapore. Electronic address:

Introduction: Spontaneous rupture of HCC (srHCC) is a life-threatening sequela of HCC characterized by a high mortality. Liver resection (LR) is the ideal therapeutic strategy as it not only arrests hemorrhage but also remove the offending tumour. We sought to determine the impact of spontaneous rupture on the survival outcomes of patients after LR by performing a propensity score matched (PSM) analysis comparing patients who underwent LR for srHCC versus non-ruptured (nrHCC). Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.044DOI Listing

Observed and calculated cerebral critical closing pressure are highly correlated in preterm infants.

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.

Introduction: Cerebrovascular critical closing pressure (CrCP) is the arterial blood pressure (ABP) at which cerebral blood flow ceases. Preterm ABP is low and close to CrCP. The diastolic closing margin (diastolic ABP minus CrCP) has been associated with intraventricular hemorrhage in preterm infants. Read More

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http://dx.doi.org/10.1038/s41390-019-0403-yDOI Listing

Hydrocephalus-induced neurogenic stunned myocardium and cardiac arrest in a child: completely reversed with CSF diversion.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

Neurogenic stunned myocardium (NSM) is a potentially fatal cause of sudden cardiogenic dysfunction due to an acute neurological event, most commonly aneurysmal subarachnoid hemorrhage in adults. Only two pediatric cases of hydrocephalus-induced NSM have been reported. Here the authors report a third case in a 14-year-old boy who presented with severe headache, decreased level of consciousness, and shock in the context of acute hydrocephalus secondary to fourth ventricular outlet obstruction 3 years after standard-risk medulloblastoma treatment. Read More

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http://dx.doi.org/10.3171/2019.2.PEDS18711DOI Listing

Predictors of endoscopic third ventriculostomy ostomy status in patients who experience failure of endoscopic third ventriculostomy with choroid plexus cauterization.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

1Surgical Outcomes Center for Kids, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville.

OBJECTIVEAt failure of endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC), the ETV ostomy may be found to be closed or open. Failure with a closed ostomy may indicate a population that could benefit from evolving techniques to keep the ostomy open and may be candidates for repeat ETV, whereas failure with an open ostomy may be due to persistently abnormal CSF dynamics. This study seeks to identify clinical and radiographic predictors of ostomy status at the time of ETV/CPC failure. Read More

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https://thejns.org/view/journals/j-neurosurg-pediatr/aop/art
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http://dx.doi.org/10.3171/2019.2.PEDS18743DOI Listing
April 2019
1 Read

The post-aSAH syndrome: a self-reported cluster of symptoms in patients with aneurysmal subarachnoid hemorrhage.

J Neurosurg 2019 Apr 19:1-10. Epub 2019 Apr 19.

2Neurosurgery, Oslo University Hospital; and.

OBJECTIVEAlthough many patients recover to a good functional outcome after aneurysmal subarachnoid hemorrhage (aSAH), residual symptoms are very common and may have a large impact on the patient's daily life. The particular cluster of residual symptoms after aSAH has not previously been described in detail and there is no validated questionnaire that covers the typical problems reported after aSAH. Many of the symptoms are similar to post-concussion syndrome, which often is evaluated with the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). Read More

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http://dx.doi.org/10.3171/2019.1.JNS183168DOI Listing

Abortion Providers' experiences and views on self-managed medication abortion, an exploratory study.

Contraception 2019 Apr 16. Epub 2019 Apr 16.

University of Iowa Hospitals and Clinics, Department of Obstetrics and Gynecology, 200 Hawkins Drive, Iowa City, IA, 52242.

Objective: Data on the practice of self-managed medication abortion are limited, in part because this practice takes place purposefully outside of established healthcare systems. Given this, we aimed to ascertain abortion providers' familiarity with self-managed medication abortion and associated complications, compare regional differences, and evaluate provider attitudes.

Study Design: We distributed an online survey to members of Society for Family Planning, Association of Reproductive Health Providers, and the Abortion Care Network between July and September 2017 querying experiences with and opinions about self-managed abortion. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.04.006DOI Listing
April 2019
1 Read

Impact of Intracranial Aneurysm Morphology and Rupture Status on the Particle Residence Time.

J Neuroimaging 2019 Apr 19. Epub 2019 Apr 19.

Department of Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Background And Purpose: Aneurysm hemodynamics play an important role in aneurysm growth and subsequent rupture. Within the available hemodynamic characteristics, particle residence time (PRT) is relatively unexplored. However, some studies have shown that PRT is related to thrombus formation and inflammation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12618
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http://dx.doi.org/10.1111/jon.12618DOI Listing
April 2019
1 Read

Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011385. Epub 2019 Apr 19.

Van Creveldkliniek / Department of Haematology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, Netherlands, 3584CT.

Background: Minor oral surgery or dental extractions (oral or dental procedures) are widely performed and can be complicated by hazardous oral bleeding, especially in people with an inherited bleeding disorder such as haemophilia or Von Willebrand disease (VWD). The amount and severity of singular bleedings depend on disease-related factors, such as the severity of the haemophilia, both local and systemic patient factors (such as periodontal inflammation, vasculopathy or platelet dysfunction) and intervention-related factors (such as the type and number of teeth extracted or the dimension of the wound surface). Similar to local haemostatic measures and suturing, antifibrinolytic therapy is a cheap, safe and potentially effective treatment to prevent bleeding complications in individuals with bleeding disorders undergoing oral or dental procedures. Read More

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http://dx.doi.org/10.1002/14651858.CD011385.pub3DOI Listing

Endotipsitis as an indication for pediatric liver transplantation.

Transpl Infect Dis 2019 Apr 19:e13097. Epub 2019 Apr 19.

Hepatobiliary Surgery and Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.

Endotipsitis is a rare but severe complication of transjugular intrahepatic portosystemic shunt (TIPS), a device widely used to treat portal hypertension in adults, but sparsely used in children. We report a case of endotipsitis in a 3-year-old child affected of biliary atresia. She underwent a Kasai procedure at 3 months of age but, although the bile flow was restored, she presented upper gastrointestinal bleeding due to portal hypertension 1. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/tid.13097
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http://dx.doi.org/10.1111/tid.13097DOI Listing
April 2019
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Safety and Efficacy of Minimally Interrupted Dabigatran vs Uninterrupted Warfarin Therapy in Adults Undergoing Atrial Fibrillation Catheter Ablation: A Randomized Clinical Trial.

JAMA Netw Open 2019 Apr 5;2(4):e191994. Epub 2019 Apr 5.

Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Importance: Uninterrupted dabigatran therapy reduces stroke risk in patients with nonvalvular atrial fibrillation (NVAF) undergoing ablation and is associated with a lower bleeding risk than uninterrupted warfarin therapy. Minimally interrupted direct oral anticoagulant therapy is widely used, but data from controlled studies are insufficient.

Objective: To compare the safety and efficacy of minimally interrupted dabigatran vs uninterrupted warfarin therapy in patients undergoing catheter ablation for NVAF. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.1994DOI Listing

IL-10 inhibits apoptosis in brain tissue around the hematoma after ICH by inhibiting proNGF.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3005-3011

Department of Geratology, Yantai Yuhuangding Hospital, Yantai, China.

Objective: To explore the roles of interleukin-10 (IL-10), proNGF and p75NTR in apoptosis of brain tissues induced by intracerebral hemorrhage (ICH).

Patients And Methods: According to the time of sample collection after ICH, brain tissue samples were divided into < 6 h group, 6-24 h group (including 24 h), 24-72 h group (including 72 h) and > 72 h group. Meanwhile, 10 tissues that dropped from the beginning at the cortical stoma (distal part of the hematoma) were harvested as controls. Read More

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http://www.europeanreview.org/article/17582
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http://dx.doi.org/10.26355/eurrev_201904_17582DOI Listing
April 2019
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Iatrogenic atrial septal defect closure after transseptal mitral valve interventions: Indications and outcomes.

Catheter Cardiovasc Interv 2019 Apr 19. Epub 2019 Apr 19.

Division of Cardiovascular Medicine, UC Davis Medical Center, Sacramento, California.

Objectives: Review indications and outcomes for transcatheter iatrogenic atrial septal defect (iASD) closure in patients undergoing MitraClip or transseptal (TS) mitral valve-in-valve/ring (ViV/ViR) procedures.

Background: Mitral valve transcatheter interventions require large-diameter TS sheaths that can result in iASDs that necessitate post-procedure transcatheter closure. Although the presence of iASD has been well-described, indications for closure and outcomes after TS mitral valve interventions have not been reported. Read More

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http://dx.doi.org/10.1002/ccd.28294DOI Listing

Shock index thresholds to predict adverse outcomes in maternal hemorrhage and sepsis: a prospective cohort study.

Acta Obstet Gynecol Scand 2019 Apr 18. Epub 2019 Apr 18.

Department of Women and Children's Health, King's College London, London, UK.

Introduction: Shock Index (SI) is a predictor of hemodynamic compromise in obstetric patients. The Shock Index threshold for action is not well understood. We aimed to evaluate Shock Index thresholds as predictors of outcomes in obstetric patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/aogs.13626
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http://dx.doi.org/10.1111/aogs.13626DOI Listing
April 2019
1 Read

Efficacy and safety of figure-of-eight suture versus manual pressure for venous access closure: a systematic review and meta-analysis.

J Interv Card Electrophysiol 2019 Apr 18. Epub 2019 Apr 18.

Kansas City Heart Rhythm Institute and Research Foundation, Kansas City, KS, USA.

Background: Vascular hemostasis after venous access in cardiovascular procedures remains a challenge. Figure-of-eight (FoE) emerged as an alternative technique to manual pressure. However, its feasibility and safety is unknown. Read More

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http://dx.doi.org/10.1007/s10840-019-00547-6DOI Listing

Utilization and safety of extracranial-intracranial bypass surgery in symptomatic steno-occlusive disorders.

Brain Circ 2019 Jan-Mar;5(1):32-35. Epub 2019 Mar 27.

Department of Neurology, UT Health McGovern School of Medicine, Houston, Texas, USA.

Objective: The objective of this study was to investigate patterns of utilization and safety of extracranial-intracranial (EC-IC) bypass in patients with symptomatic cerebrovascular steno-occlusive disorders.

Methods: Patients with one of the steno-occlusive conditions (defined as symptomatic intracranial stenosis, extracranial stenosis, and moyamoya disease) were identified using all nonfederal hospitalizations in New York (2005-2014) and Florida (2005-2015). EC-IC bypass surgery was defined using the corresponding procedure codes. Read More

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http://dx.doi.org/10.4103/bc.bc_33_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458777PMC

Effect of remote ischemic preconditioning on cerebral vasospasm and biomarkers of cerebral ischemia in aneurysmal subarachnoid hemorrhage (ERVAS): A protocol for a randomized, controlled pilot trial.

Brain Circ 2019 Jan-Mar;5(1):12-18. Epub 2019 Mar 27.

Department of Neuroanaesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Introduction: Cerebral vasospasm is a dreaded complication of aneurysmal subarachnoid hemorrhage (aSAH) predisposing to delayed cerebral ischemia. We intend to study the cerebroprotective effects of remote ischemic preconditioning (RIPC) in patients with aSAH.

Materials And Methods: This is a single-center, prospective, parallel group, randomized, pilot trial, approved by the Institutional Ethics Committee. Read More

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http://dx.doi.org/10.4103/bc.bc_26_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458778PMC

Treatment for ischemic stroke: From thrombolysis to thrombectomy and remaining challenges.

Brain Circ 2019 Jan-Mar;5(1):8-11. Epub 2019 Mar 27.

Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA.

Stroke is a leading cause of death and long-term disabilities. Despite decades of extensive efforts in search of brain injury mechanisms and therapeutic interventions, pharmacological treatment is limited to the use of thrombolytic agent tissue plasminogen activator, which has limited therapeutic time window and potential side effect of intracranial hemorrhage. Over the past few years, endovascular thrombectomy with stent-retriever devices combined with advanced imaging modalities has transformed the standard of stroke care, offering an opportunity to improve the outcome in selected patients as late as 24 h after the onset of stroke. Read More

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http://www.braincirculation.org/text.asp?2019/5/1/8/255026
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http://dx.doi.org/10.4103/bc.bc_36_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458775PMC
March 2019
1 Read

Clinical Experience with Hemopatch® as a Dural Sealant in Cranial Neurosurgery.

Cureus 2019 Feb 4;11(2):e4013. Epub 2019 Feb 4.

Department of Neurosurgery, University Medical Centre of Regensburg, Regensburg, DEU.

Background: Herein, we report our clinical experience with the novel polyethylene glycol-covered matrix dural onlay, Hemopatch® (Baxter Deutschland GmbH, Unterschleißheim, Germany) for the prevention of postoperative cerebrospinal fluid (CSF) fistulas.

Methods: Retrospectively, 22 consecutive patients (11 females, 11 males, mean age: 49.8 years, range: 15-77 years) with oncological and vascular intracranial lesions were included in this study. Read More

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https://www.cureus.com/articles/17296-clinical-experience-wi
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http://dx.doi.org/10.7759/cureus.4013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450590PMC
February 2019
2 Reads

A Case of Spontaneous Spinal Subdural Hematoma Complicated by Cranial Subarachnoid Hemorrhage and Spinal Adhesive Arachnoiditis.

Case Rep Orthop 2019 13;2019:7384701. Epub 2019 Mar 13.

Department of Orthopedic Surgery, Toho University, Tokyo, Japan.

A 76-year-old woman with a spinal subdural hematoma (SDH) was presented with severe back pain without headache. Magnetic resonance imaging (MRI) performed 4 days after onset showed SDH extending from Th2 to L3. She was diagnosed with spontaneous SDH without neurological manifestation, and conservative treatment was selected. Read More

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http://dx.doi.org/10.1155/2019/7384701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436331PMC

Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric Varices.

Case Rep Obstet Gynecol 2019 14;2019:5702983. Epub 2019 Mar 14.

Department of General Internal Medicine, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.

Extra-hepatic portal vein thrombosis (EHPVO) represents the obstruction of the portal vein outside the liver and is not related to chronic liver disease or neoplasia. In chronic EHPVO, collateral veins and portal hypertension develop, resulting in splenomegaly and variceal formation. Myeloproliferative neoplasms (MPN) are the most frequent acquired etiology of EHPVO. Read More

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http://dx.doi.org/10.1155/2019/5702983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437724PMC

Cognitive Development Trajectories in Preterm Children With Very Low Birth Weight Longitudinally Followed Until 11 Years of Age.

Front Physiol 2019 2;10:307. Epub 2019 Apr 2.

Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

There is a high prevalence of cognitive dysfunction in very low birthweight (500-1250 g) infants (VLBW). Understanding long-term risk factors associated with cognitive development in preterm children requires longitudinal characterization. Thus, follow-up evaluations, including identification of risks and resilience influences-are important to promote health and cognitive abilities of children born preterm. Read More

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http://dx.doi.org/10.3389/fphys.2019.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454032PMC

Intracranial Hemorrhage in a Young Woman: An Unusual Initial Presentation of Undiagnosed Choriocarcinoma.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):371-373

Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India.

Choriocarcinoma is an uncommon tumor. Undiagnosed choriocarcinoma initially presenting with intracranial hemorrhage in an apparently healthy female is rare and presents a diagnostic difficulty. The authors report a case presenting as intracranial hemorrhage of unsuspected choriocarcinoma. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_307_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454938PMC

Decompression Hemicraniectomy for Refractory Intracranial Hypertension in Reversible Cerebral Vasoconstriction Syndrome.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):355-359

Division of Neurocritical Care, Cerebrovascular Center, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Reversible cerebral vasoconstriction syndrome (RCVS) is a disorder of dysregulation of cerebrovascular tone resulting in transient segmental vasoconstriction which resolves in 1-3 months. Cerebral edema is an underrecognized complication in RCVS. It is likely multifactorial. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_334_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454955PMC

Microsurgical Management for Aneurysm Arising from a Low-Lying Internal Carotid Artery-Posterior Communicating Artery Bifurcation through the Anterior Temporal Approach.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):331-333

Department of Neurosurgery, Iwate Prefectural Chubu Hospital, Kitakami, Iwate, Japan.

A low-lying internal carotid artery (ICA) running closer to the skull base than in usual cases prevents use of the standard transsylvian approach (TSA) to view an aneurysm through the retrocarotid space. A 75-year-old male had a 10-day history of headache and left eyelid ptosis. Initial computed tomography (CT) showed no evidence of subarachnoid hemorrhage. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/331/254
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http://dx.doi.org/10.4103/jnrp.jnrp_274_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454945PMC
April 2019
1 Read

Extended Window for Stroke Thrombectomy.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):294-300

Department of Neurological Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA.

Objective: Mechanical thrombectomy is the standard treatment for large vessel occlusion (LVO) in acute ischemic stroke (AIS) up to 6 h after onset. Recent trials have demonstrated a benefit for wake-up strokes and patients beyond 6 h.

Methods: A systematic literature review was conducted for multicenter randomized clinical trials (RCTs) investigating endovascular stroke treatment using perfusion imaging to identify patients that may benefit from mechanical thrombectomy for AIS beyond 6 h of onset. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/294/254
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http://dx.doi.org/10.4103/jnrp.jnrp_365_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454953PMC
April 2019
1 Read

Pattern of Emergent Head Computed Tomography Findings in a Tertiary Care Hospital during off Working Hours: Retrospective Analysis.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):207-211

Department of Radiodiagnosis, Indian Naval Hospital Ship Asvini, Mumbai, Maharashtra, India.

Introduction: Emergency head computed tomography (CT) is rising exponentially during off working hours due to evidence-based medicine, patient's expectation and desires, easy availability and apprehension of medico-legal cases, thereby raising health-care cost. There is huge gap in demand and supply of radiologist, especially during off working hours. There is need to know the pattern of emergency head findings. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/207/254
Publisher Site
http://dx.doi.org/10.4103/jnrp.jnrp_362_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454959PMC
April 2019
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Oral Health Behavior and Treatment Needs among Drug Addicts and Controls in Amritsar District: A Case-controlled Study.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):201-206

Department of Oral Medicine and Radiology, PGIDS, Rohtak, Haryana, India.

Background: Substance and drug abuse is associated with severe psychosocial problems, violence and health complications.

Aims: The aim of the study was to evaluate and compare the oral hygiene status and sugar eating patterns among drug addicts with their age, gender and socio-economic status matched controls.

Settings And Design: The present study comprised of two groups-Group A comprised of 100 drug addicts and Group B included 100 controls. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/201/254
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http://dx.doi.org/10.4103/jnrp.jnrp_309_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454970PMC
April 2019
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Comparison of Full Outline of UnResponsiveness (FOUR) score and the conventional scores in predicting outcome in aneurysmal subarachnoid haemorrhage patients.

Indian J Anaesth 2019 Apr;63(4):295-299

Department of Anaesthesiology, King Fahad Medical College, Riyadh, Saudi Arabia.

Background And Aims: Full Outline of UnResponsiveness (FOUR) score is a more comprehensive score used to assess eye response, motor response, brainstem reflexes, and respiration that was introduced to overcome the drawbacks of Glasgow coma scale (GCS) score. Our aim was to assess which score best predicts mortality and poor outcome in aneurysmal subarachnoid haemorrhage (aSAH) patients.

Methods: This cohort study, prospectively evaluated the use of FOUR score to assess the mortality and outcome in aSAH patients during the period from November 2015 to November 2016. Read More

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http://dx.doi.org/10.4103/ija.IJA_786_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460986PMC

Evaluation of performance of C-MAC video laryngoscope Miller blade size zero for endotracheal intubation in preterm and ex-preterm infants: A retrospective analysis.

Indian J Anaesth 2019 Apr;63(4):284-288

Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

Background And Aims: The preterm and ex-preterm babies form a separate group among the paediatric population with unique airway anatomy. The utility of C-MAC Video laryngoscope (VL) for routine intubation of preterm babies has not been evaluated. The purpose of this study is to report the performance of C-MAC VL Miller blade size-0 for endotracheal intubation in preterm babies at our institute. Read More

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http://www.ijaweb.org/text.asp?2019/63/4/284/255457
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http://dx.doi.org/10.4103/ija.IJA_753_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460968PMC
April 2019
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Predicting Motor Outcome in Acute Intracerebral Hemorrhage.

AJNR Am J Neuroradiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurology (M.T., J.S., Y.S.), Girona Biomedical Research Institute, Dr Josep Trueta University Hospital, Girona, Spain.

Background And Purpose: Predicting motor outcome following intracerebral hemorrhage is challenging. We tested whether the combination of clinical scores and DTI-based assessment of corticospinal tract damage within the first 12 hours of symptom onset after intracerebral hemorrhage predicts motor outcome at 3 months.

Materials And Methods: We prospectively studied patients with motor deficits secondary to primary intracerebral hemorrhage within the first 12 hours of symptom onset. Read More

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http://www.ajnr.org/lookup/doi/10.3174/ajnr.A6038
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http://dx.doi.org/10.3174/ajnr.A6038DOI Listing
April 2019
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Double-balloon enteroscopy: Experience with an innovative endoscopic technique at the Hospital Universitario de la Fundación Santa Fe de Bogotá.

Rev Gastroenterol Mex 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Medicina Interna, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, D.C., Colombia.

Introduction And Aims: Double-balloon enteroscopy is a recently introduced endoscopic method that enables complete visualization of the small bowel, as well as biopsy sampling and therapeutic interventions in that part of the intestine. The aim of the present study was to describe the experience acquired at our hospital to determine the characteristics of the patients that underwent the procedure.

Materials And Methods: A descriptive, cross-sectional study was conducted on all patients above 18 years of age admitted to the Hospital Universitario de la Fundación Santa Fe de Bogotá for double-balloon enteroscopy, within the time frame of January 2013 to December 2017. Read More

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http://dx.doi.org/10.1016/j.rgmx.2019.01.001DOI Listing

PillCam SB3 vs. PillCam SB2: Can technologic advances in capsule endoscopy improve diagnostic yield in patients with small bowel bleeding?

Rev Gastroenterol Mex 2019 Apr 15. Epub 2019 Apr 15.

Servicio de Endoscopia, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Introduction And Objective: The SB3 capsule endoscopy system has better image resolution and the capacity to increase the number of images from 2 to 6 frames per second. Small bowel bleeding is the most common indication. The aim To determine if the advances in capsule endoscopy technology increase diagnostic yield in cases of small bowel bleeding, according to the Saurin classification. Read More

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http://dx.doi.org/10.1016/j.rgmx.2018.11.008DOI Listing