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Pediatr Radiol 2022 Jun 10. Epub 2022 Jun 10.

Department of Diagnostic Imaging, Health Science Center, Children's Hospital of Winnipeg, University of Manitoba, JM281-840 Sherbrook St., Winnipeg, MB, R2A 1S1, Canada.

Blastomycosis is caused by Blastomyces dermatitidis, a thermally dimorphic fungus that lives in the form of spores in the soil in North America. The main mode of transmission is through the inhalation of these spores. Despite the importance of knowing the imaging characteristics of blastomycosis given the suggested high rates of dissemination in symptomatic children, a paucity of literature focuses on the imaging patterns of blastomycosis in the pediatric population. Read More

Indian J Dermatol 2022 Jan-Feb;67(1):84-86

Department of Dermatology, Venereology and Leprosy, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India E-mail:

Am J Med 2022 May 27. Epub 2022 May 27.

Department of Medicine, University of Toronto, Toronto, Canada; Division of Infectious Diseases, University Health Network, Toronto, Canada; Division of General Internal Medicine, University Health Network, Toronto, Canada.

J Fungi (Basel) 2022 May 10;8(5). Epub 2022 May 10.

Graduate Research and Innovation Program, Centro Universitario FMABC, Santo André 09060-870, SP, Brazil.

Lobomycosis is a chronic disease caused by , which is endemic to the Amazon rainforest, where it affects forest dwellers in Brazil. There is no disease control program and no official therapeutic protocol. This situation contributes to an unknown disease prevalence and unmet needs of people disabled by this disease who seek access to treatment. Read More

J Fungi (Basel) 2022 Apr 28;8(5). Epub 2022 Apr 28.

Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, UK.

Fungal infections commonly present with myriad symptoms that mimic other clinical entities, notable amongst which is tuberculosis. Besides histoplasmosis and chronic pulmonary aspergillosis, which can mimic TB, this review has identified several other fungal infections which also do. A total of 80 individual cases misdiagnosed as TB are highlighted: aspergillosis ( = 18, 22. Read More

Radiol Clin North Am 2022 May;60(3):409-427

Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue MC 3252, Madison, WI 53792-3252, USA. Electronic address:

Histoplasmosis, blastomycosis, and coccidioidomycosis are endemic fungal infections in North America. Many infections are subclinical, and many symptomatic infections are mild. Pneumonia is the most common clinical manifestation. Read More

N Engl J Med 2022 05;386(18):e49

Saint Louis University, Saint Louis, MO

Cureus 2022 Mar 31;14(3):e23700. Epub 2022 Mar 31.

Anesthesiology, Wayne State University School of Medicine, Detroit, USA.

Fibrosing mediastinitis (FM) is an uncommon diagnosis that involves the proliferation of extensive, dense fibrous tissue in the mediastinum. FM accounts for less than 1% of people with prior infection by that develop hypersensitivity immune responses to antigens released during the initial exposure. Other causes include tuberculosis, blastomycosis, sarcoidosis, radiation, and idiopathic. Read More

J Vet Dent 2022 May 3:8987564221098166. Epub 2022 May 3.

468706Barrington Animal Hospital, Barrington, IL, USA.

A case of localized oral mandibular blastomycosis is described in a five-year-old dog. Complete resolution of clinical signs and oral radiographic changes were seen following itraconazole therapy at 5 mg/kg/day for four and a half months. The patient remained free of at the one year follow up based on the Mira Vista urine antigen test by EIA (Enzyme Immunoassay). Read More

Mycoses 2022 Jun 25;65(6):599-612. Epub 2022 May 25.

Durham County Department of Public Health, Durham, North Carolina, USA.

Biological sex, which comprises differences in host sex hormone homeostasis and immune responses, can have a substantial impact on the epidemiology of infectious diseases. Comprehensive data on sex distributions in invasive fungal diseases (IFDs) are lacking. In this review, we performed a literature search of in vitro/animal studies, clinical studies, systematic reviews and meta-analyses of invasive fungal infections. Read More

JAAD Case Rep 2022 May 2;23:52-54. Epub 2022 Mar 2.

Division of Dermatology, Rush University Medical Center, Chicago, Illinois.

IDCases 2022 7;28:e01463. Epub 2022 Mar 7.

Main Line Health, United States.

Blastomycosis is an endemic mycosis in the United States that typically affects the respiratory tract and presents as a pneumonia. Dissemination can occur to any organ system, most commonly involving the skin or bones. Treatment of blastomycosis depends on the severity of disease and consists of itraconazole with liposomal amphotericin B added in during the initial stage in those with more severe disease or those who are pregnant. Read More

Cureus 2022 Feb 14;14(2):e22207. Epub 2022 Feb 14.

Internal Medicine, Jinnah Hospital, Lahore, PAK.

Blastomycosis is a systemic mycosis endemic to the Midwestern and South Central United States. Infection is caused by inhaling spores of () that inhabit soil. Acute respiratory distress syndrome (ARDS) is a rare complication of pulmonary blastomycosis with a significantly high mortality rate. Read More

BMC Infect Dis 2022 Mar 7;22(1):228. Epub 2022 Mar 7.

Division of Infectious Diseases, Department of Internal Medicine, King Fahad Hospital, Al Ahsa, Kingdom of Saudi Arabia.

Background: Blastomycosis is a disease caused by the fungus Blastomyces-a thermally dimorphic fungus that can cause granulomatous and/or purulent infection.

Case Presentation: We report here a case of chronic blastomycosis infection in a 24-year-old male patient from Saudi Arabia who presented with recurrent skin abscesses associated with deep-seated and multilevel paraspinal (dorsal and lumbar) collections and bilateral empyema with pulmonary involvement and bilateral psoas abscesses. The diagnosis was made after a CT-guided pleural biopsy revealed the characteristic histopathological findings of blastomycosis. Read More

Clin Case Rep 2022 Feb 25;10(2):e05479. Epub 2022 Feb 25.

Department of Dermatology Charles Nicolle Hospital Tunis Tunisia.

Blastomycosis-like pyoderma is a rare skin disorder most commonly caused by bacterial infection. It is usually diagnosed in immunocompromised patients. We report a case of BLP in an immunocompetent woman, who presented with a 6-week history of verrucous cutaneous plaque of the left wrist. Read More

Cureus 2022 Jan 26;14(1):e21634. Epub 2022 Jan 26.

Hematology/Oncology, Henry Ford Health System, Detroit, USA.

Blastomycosis is caused by , a dimorphic fungus that primarily causes pulmonary disease. Cutaneous blastomycosis is infrequent and tends to be misdiagnosed given its similar presentation to other cutaneous fungal infections and malignancies. A 51-year-old woman presented with a two-month history of disfiguring nasal lesions. Read More

Front Oral Health 2022 3;3:838639. Epub 2022 Feb 3.

Department of Oral Sciences, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.

Oral fungal infections have afflicted humans for millennia. Hippocrates (. 460-370 BCE) described two cases of oral aphthae associated with severe underlying diseases that could well have been oral candidiasis. Read More

Ann Emerg Med 2022 03;79(3):311-314

Department of Emergency Medicine, John H Stroger Hospital of Cook County, Chicago, IL.

Cutis 2021 Dec;108(6):E12-E13

Dr. Cotter is from the Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison. Dr. Cheng is from the Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles. Dr. Marathe is from Children's National Health System, Washington, DC.

Urol Case Rep 2022 May 24;42:102007. Epub 2022 Jan 24.

Division of Urology, Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.

Blastomycosis is an endemic infection caused by Blastomyces dermatitidis, found primarily in the southeastern, south-central, and Midwest United States. While the majority of infections typically present with pulmonary manifestations, they rarely present with symptoms isolated to the prostate. In order to better understand the clinical presentation, evaluation, and treatment of blastomycosis of the prostate, we present a 59-year-old male with urinary retention and lower urinary tract symptoms (LUTS). Read More

JAAD Case Rep 2022 Mar 7;21:29-31. Epub 2022 Jan 7.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

mBio 2022 Jan 4:e0340021. Epub 2022 Jan 4.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild mice with known genetic variation, assembled in genetic reference panels. In this work, we describe wide natural variation in both primary and acquired resistance to experimental pulmonary blastomycosis in eight founder strains, including 129, A/J, BL/6, CAST, NOD, NZO, PWK, and WSB of the Collaborative Cross collection, and the inbred DBA strain. Read More

Diagnosis (Berl) 2022 Jan 20. Epub 2022 Jan 20.

Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Objectives: Diagnostic delays are a major source of morbidity and mortality. Despite the adverse outcomes associated with diagnostic delays, few studies have examined the incidence and factors that influence diagnostic delays for different infectious diseases. The objective of this study was to understand the relative frequency of diagnostic delays for six infectious diseases commonly seen by infectious diseases (ID) consultants and to examine contributing factors for these delays. Read More

IDCases 2022 11;27:e01400. Epub 2022 Jan 11.

Rheumatology department, CHUS - Sherbrooke Hospital, Canada.

Am J Case Rep 2022 Jan 9;23:e935059. Epub 2022 Jan 9.

Department of Pharmacy, Mercy Health St. Elizabeth Boardman Hospital, Boardman, OH, USA.

BACKGROUND Blastomycosis is a rare opportunistic disease caused by inhalation of the fungus Blastomyces dermatitidis. Blastomycosis can occur in all individuals but is most commonly seen in immunocompromised hosts. If left untreated or not caught early enough, blastomycosis can progress to fulminant multilobar pneumonia, acute respiratory distress syndrome (ARDS), and even death. Read More

Lung 2022 02 6;200(1):129-135. Epub 2022 Jan 6.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Introduction: Blastomycosis is an uncommon; potentially life-threatening granulomatous fungal infection. The aim of this study is to report hospital and intensive care unit (ICU) outcomes of patients admitted with blastomycosis.

Methods: All patients admitted for treatment of blastomycosis at the Mayo Clinic-Rochester, Minnesota between 01/01/2006 and 09/30/2019 were included. Read More

J Am Vet Med Assoc 2021 12 21;260(4):422-427. Epub 2021 Dec 21.

Objective: To document ocular findings in cats with blastomycosis.

Animals: 35 cats with blastomycosis.

Procedures: Medical records from 1978 through 2019 were reviewed to identify cats with confirmed Blastomyces infection. Read More

Biomed Pharmacother 2022 Feb 10;146:112523. Epub 2021 Dec 10.

Faculty of Chemistry, Department of Organic and Medicinal Chemistry, Wrocław University of Science and Technology, 27 Wybrzeże Wyspiańskiego St, 50-370 Wrocław, Poland.

Four types of antifungal drugs are available that include inhibitors of ergosterol synthesis, of fungal RNA biosynthesis, and of cell wall biosynthesis as well as physiochemical regulators of fungal membrane sterols. Increasing resistance to antifungal drugs can severely limit treatment options of fungal nail infections, vaginal candidiasis, ringworm, blastomycosis, histoplasmosis, and Candida infections of the mouth, throat, and esophagus, among other infections. Development of strategies focused on new fungicides can effectively help tackle troublesome fungal diseases. Read More

J Pediatric Infect Dis Soc 2022 Feb;11(2):81-84

Department of Pediatrics, Division of Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Blastomyces dermatitidis is a fungus endemic to the Ohio and Mississippi river valley region and great lakes region. Exposure is typically associated with outdoor activities near streams, rivers, or moist soil. Pulmonary disease is the main manifestation, whereas dissemination is more frequently observed in immunosuppressed individuals. Read More

Mycoses 2022 Feb 29;65(2):239-246. Epub 2021 Dec 29.

Division of Infectious Diseases, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

Background: Blastomycosis is an endemic fungal infection that causes pulmonary and systemic disease. It can occur irrespective of the patient's immune status. The risk factors associated with the severity of the disease are not well studied. Read More