30,151 results match your criteria Blast Injuries


Bacteriome-associated Wolbachia of the parthenogenetic termite Cavitermes tuberosus.

FEMS Microbiol Ecol 2018 Dec 14. Epub 2018 Dec 14.

Evolutionary Biology & Ecology, Université libre de Bruxelles, Avenue F.D. Roosevelt 50, CP 160/12, B-1050 Brussels, Belgium.

Wolbachia has deeply shaped the ecology and evolution of many arthropods, and interactions between the two partners are a continuum ranging from parasitism to mutualism. Non-dispersing queens of the termite Cavitermes tuberosus are parthenogenetically produced through gamete duplication, a mode of ploidy restoration generally induced by Wolbachia. These queens display a bacteriome-like structure in the anterior part of the mesenteron. Read More

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December 2018

Clinical diagnosis of adult patients with acute megakaryocytic leukemia.

Oncol Lett 2018 Dec 25;16(6):6988-6997. Epub 2018 Sep 25.

Worldwide Medical Center, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.

Acute megakaryocytic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML), which is challenging to diagnose due to frequent myelofibrosis (MF) and a low percentage of blast cells. In the present study, clinical characteristics and experimental observations in 9 adult patients diagnosed with AMKL, who were recruited by the Sino-U.S. Read More

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December 2018

Azacitidine with or without lenalidomide in higher risk myelodysplastic syndrome & low blast acute myeloid leukemia.

Haematologica 2018 Dec 13. Epub 2018 Dec 13.

Peter MacCallum Cancer Centre, Melbourne, Australia.

Standard treatment for higher risk myelodysplastic syndromes, chronic myelomonocytic leukemia and low blast acute myeloid leukemia is azacitidine. In single arm studies, adding lenalidomide had been suggested to improve outcomes. The ALLG MDS4 phase II trial randomized such patients to standard azacitidine or combination azacitidine (75mg/m2/d days 1 to 5) with lenalidomide (10mg days 1-21 of 28-day cycle from cycle 3) to assess clinical benefit (alive without progressive disease) at 12 months. Read More

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December 2018
2 Reads

RNA sequencing and anthocyanin synthesis-related genes expression analyses in white-fruited Vaccinium uliginosum.

BMC Genomics 2018 Dec 13;19(1):930. Epub 2018 Dec 13.

Agriculture College of YanBian University, Yanji, Jilin, 133002, China.

Background: Vaccinium uliginosum (Ericaceae) is an important wild berry having high economic value. The white-fruited V. uliginosum variety found in the wild lacks anthocyanin and bears silvery white fruits. Read More

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December 2018

Chrysoviruses in .

Viruses 2018 Dec 8;10(12). Epub 2018 Dec 8.

Laboratory of Plant Pathology, Department of Applied Biological Sciences, Tokyo University of Agriculture and Technology, 3-5-8, Saiwaicho, Fuchu, Tokyo 184-8509, Japan.

, the fungus that causes rice blast, is the most destructive pathogen of rice worldwide. A number of mycoviruses have been identified. These include viruses 1, 2, and 3 (MoV1, MoV2, and MoV3) belonging to the genus, , in the family, ; partitivirus 1 (MoPV1) in the family, ; chrysovirus 1 strains A and B (MoCV1-A and MoCV1-B) belonging to cluster II of the family, ; a mycovirus related to plant viruses of the family, ( virus A); and a (+)ssRNA mycovirus closely related to the ourmia-like viruses ( ourmia-like virus 1). Read More

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December 2018

Using the 6RL Minichromosome of Rye ( L.) to Create Wheat-Rye 6D/6RL Small Segment Translocation Lines with Powdery Mildew Resistance.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

College of Agronomy, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China.

Long arms of rye ( L.) chromosome 6 (6RL) carry powdery mildew resistance genes. However, these sources of resistance have not yet been successfully used in commercial wheat cultivars. Read More

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December 2018

Blast-induced traumatic brain injury: the experience from a level I trauma center in southern Thailand.

Authors:

Neurosurg Focus 2018 Dec;45(6):E7

OBJECTIVEIn the ongoing conflict in southern Thailand, the improvised explosive device (IED) has been a common cause of blast-induced traumatic brain injury (bTBI). The authors investigated the particular characteristics of bTBI and the factors associated with its clinical outcome.METHODSA retrospective cohort study was conducted on all patients who had sustained bTBI between 2009 and 2017. Read More

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December 2018

Comparative Mapping Combined With Map-Based Cloning of the Genome Reveals a Candidate Gene for Multilocular Rapeseed.

Front Plant Sci 2018 27;9:1744. Epub 2018 Nov 27.

State Key Laboratory of Plateau Ecology and Agriculture of Qinghai University, Key Laboratory of Spring Rape Genetic Improvement of Qinghai Province, National Key Laboratory Breeding Base for Innovation and Utilization of Plateau Crop Germplasm, Academy of Agricultural and Forestry Sciences of Qinghai University, Xining, China.

Multilocular traits exist in a variety of plants and exert important effects on plant yield. Previous genetic studies have shown that multilocular trait of the cultivar Duoshi is controlled by two recessive genes, and . In previous studies, the gene is located on chromosome A07, and the candidate gene is . Read More

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November 2018

A nearest-neighbors network model for sequence data reveals new insight into genotype distribution of a pathogen.

BMC Bioinformatics 2018 Dec 12;19(1):475. Epub 2018 Dec 12.

School of Electrical Engineering and Computer Science, Washington State University, Pullman, WA, USA.

Background: Sequence similarity networks are useful for classifying and characterizing biologically important proteins. Threshold-based approaches to similarity network construction using exact distance measures are prohibitively slow to compute and rely on the difficult task of selecting an appropriate threshold, while similarity networks based on approximate distance calculations compromise useful structural information.

Results: We present an alternative network representation for a set of sequence data that overcomes these drawbacks. Read More

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December 2018

Screening and Identification of Linear B Cell Epitopes Within the Nonstructural Proteins of Enterovirus 71.

Viral Immunol 2018 Dec 6. Epub 2018 Dec 6.

Department of Laboratory Medicine, School of Medicine, Shaoxing University , Shaoxing, P.R. China .

Enterovirus 71 (EV-A71) has attracted widespread attention in the past decade because of its higher neurotropicity in addition to causing hand-foot-and-mouth disease (HFMD). Mapping epitopes of viral proteins may promote our understanding of antiviral humoral immunity, and is useful for clinical application. In this study, the linear B cell epitopes within nonstructural proteins of EV-A71 were identified using bioinformatics methods combined with peptide enzyme-linked immunosorbent assay (ELISA). Read More

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December 2018
1.636 Impact Factor

Effect of Tissue Material Properties in Blast Loading: Coupled Experimentation and Finite Element Simulation.

Ann Biomed Eng 2018 Dec 6. Epub 2018 Dec 6.

Biomedical Engineering Department, New Jersey Institute of Technology, Newark, NJ, USA.

Computational models of blast-induced traumatic brain injury (bTBI) require a robust definition of the material models of the brain. The mechanical constitutive models of these tissues are difficult to characterize, leading to a wide range of values reported in literature. Therefore, the sensitivity of the intracranial pressure (ICP) and maximum principal strain to variations in the material model of the brain was investigated through a combined computational and experimental approach. Read More

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December 2018

Loss of plasmacytoid dendritic cell differentiation is highly predictive for post-induction measurable residual disease and inferior outcomes in acute myeloid leukemia.

Haematologica 2018 Dec 6. Epub 2018 Dec 6.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Measurable residual disease is associated with inferior outcomes in patients with acute myeloid leukemia. Measurable residual disease monitoring enhances risk stratification and may guide therapeutic intervention. European LeukemiaNet working party recently came to a consensus recommendation incorporating leukemia associated immunophenotype-based different from normal approach by multi-color flow cytometry for measurable residual disease evaluation. Read More

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December 2018

Commonly misunderstood parameters of NCBI BLAST and important considerations for users.

Bioinformatics 2018 Dec 12. Epub 2018 Dec 12.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.

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December 2018
1 Read

Detection molecular of Rangelia vitalii in dogs from Parana State, Southern Brazil.

Rev Bras Parasitol Vet 2018 Dec 10. Epub 2018 Dec 10.

Programa de Pós-graduação em Ciências Veterinárias, Universidade Federal do Paraná - UFPR, Curitiba, PR, Brasil.

Rangelia vitalii infects erythrocytes, leukocytes and endothelial cells of dogs. The present study aimed to report the molecular detection confirmed by sequencing of R. vitalii in the state of Paraná, as well as describe the clinical, hematological and biochemical alterations of the infected dogs. Read More

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December 2018

Viruses and long non-coding RNAs: implicating an evolutionary conserved region.

Virusdisease 2018 Dec 24;29(4):478-485. Epub 2018 Sep 24.

1Student Research Committee, School of Medicine, Golestan University of Medical Sciences, Gorgan, 4916694667 Iran.

Long non-coding RNAs (lncRNAs) are a class of cellular transcripts, which are involved in various biological processes. There is conflicting data regarding to the origin of these non-coding molecules and lncRNAs are thought to be the origin of viral genome. Here we sought to find the homology between human lncRNAs and viruses. Read More

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December 2018

BASILIScan: a tool for high-throughput analysis of intrinsic disorder patterns in homologous proteins.

Authors:
Michal Barski

BMC Genomics 2018 Dec 11;19(1):902. Epub 2018 Dec 11.

Section of Virology, Department of Medicine, St Mary's Hospital, Imperial College London, London, W2 1PG, UK.

Background: Intrinsic structural disorder is a common property of many proteins, especially in eukaryotic and virus proteomes. The tendency of some proteins or protein regions to exist in a disordered state usually precludes their structural characterisation and renders them especially difficult for experimental handling after recombinant expression.

Results: A new intuitive, publicly-available computational resource, called BASILIScan, is presented here. Read More

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December 2018

Blast furnace flue dust co-processing in cement kiln - A pilot study.

Waste Manag Res 2018 Dec 11:734242X18816791. Epub 2018 Dec 11.

2 Geocycle India, ACC Limited, Thane Complex, LBS Marg, Thane, India.

An integrated steel plant generates a large amount of blast furnace flue dust - about 18-22 kg/t of hot metal - as a by-product of the production process. The major component of this flue dust is iron oxides and coke fines. The recovery and reuse of this iron and coke is very important with increasing price of conventional resources. Read More

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December 2018

First report of a novel alphapartitivirus in the basidiomycete Rhizoctonia oryzae-sativae.

Authors:
Subha Das Sampa Das

Arch Virol 2018 Dec 11. Epub 2018 Dec 11.

Division of Plant Biology, Bose Institute, Centenary Campus, P 1/12, C. I. T. Road, Scheme-VIIM, Kolkata, West Bengal, 700054, India.

Rhizoctonia oryzae-sativae is a soil-borne basidiomycete fungus that causes aggregate sheath spot disease on rice worldwide. Here, we report the complete genome sequence of a partitivirus designated as Rhizoctonia oryzae-sativae partitivirus 1 (RosPV1) infecting this fungus. The genome of RosPV1 consists of two double-stranded RNA (dsRNA) segments. Read More

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December 2018

N6-methyladenosine RNA methylation is involved in virulence of the rice blast fungus Pyricularia oryzae (syn. Magnaporthe oryzae).

FEMS Microbiol Lett 2018 Dec 11. Epub 2018 Dec 11.

State Key Laboratory for Rice Biology, College of Life Sciences, Zhejiang University, Hangzhou 310058, Zhejiang Province, China.

N6-methyladenosine (m6A) RNA methylation is a conserved modification of RNA in eukaryotes. Pyricularia oryzae, a filamentous phytopathogenic fungus, is the cause of a destructive rice blast disease that can lead to significant declines in rice production. Here, we characterized the function of m6A RNA methylation in the development and virulence of P. Read More

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December 2018

En Route Resuscitation - Utilization of CCATT to Transport and Stabilize Critically Injured and Unstable Casualties.

Mil Med 2018 Dec 7. Epub 2018 Dec 7.

University of Colorado School of Medicine, Aurora, CO.

Introduction: The U.S. Air Force utilizes specialized Critical Care Air Transport Teams (CCATT) for transporting "stabilized" patients. Read More

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December 2018
1 Read

[Agranulocytosis during therapy of chronic myeloid leukemia lymphoid blast crisis with dasatinib].

Rinsho Ketsueki 2018 ;59(11):2438-2440

Department of Hematology, Japan Community Health Care Organization, Kyoto Kuramaguchi Medical Center.

A 61-year-old female was diagnosed with a lymphoid crisis of chronic myeloid leukemia (CML) in February 201X and started chemotherapy combined with dasatinib (DAS). After 1 month of initiating second consolidation therapy, the neutrophils decreased to 1%, bone marrow examination revealed large granular lymphocytes (LGL) at 13%, and complete cytogenetic remission was attained (CCyR). Suspecting DAS-induced agranulocytosis, DAS was discontinued. Read More

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January 2018
2 Reads

and mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation.

Blood Adv 2018 Dec;2(23):3526-3539

Hematopathology Diagnostic Service, Department of Pathology.

The genetic aberrations that drive mixed phenotype acute leukemia (MPAL) remain largely unknown, with the exception of a small subset of MPALs harboring and translocations. We performed clinicopathologic and genetic evaluation of 52 presumptive MPAL cases at Memorial Sloan Kettering Cancer Center. Only 29 out of 52 (56%) cases were confirmed to be bona fide MPAL according to the 2016 World Heath Organization classification. Read More

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December 2018

Efficacy and toxicity of Decitabine in patients with acute myeloid leukemia (AML): A multicenter real-world experience.

Leuk Res 2018 Nov 28;76:33-38. Epub 2018 Nov 28.

Clinica Ematologica, Centro Trapianti e Terapie Cellulari, Azienda Sanitaria Universitaria Integrata, Udine, Italy.

Background: The hypomethylating agent Decitabine (DAC) is a valuable treatment option in acute myeloid leukemia (AML), particularly in elderly patients (pts) not suitable for intensive chemotherapy (CHT). However, limited data are available about efficacy and safety of DAC in clinical practice.

Patients And Methods: We retrospectively reviewed data of 104 AML pts treated with DAC in eight Italian Hematological Centers from 2015 to 2017. Read More

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November 2018
1 Read

Would the proposed pathophysiology of the "full blast" make sense here?

Authors:
Samer Kassem

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiovascular Surgery, Centro Cardiologico Monzino, IRCCS, Via parea, 4 Milano 20138.

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December 2018

Identification of novel ejaculate proteins in a seed beetle and division of labour across male accessory reproductive glands.

Insect Biochem Mol Biol 2018 Dec 7. Epub 2018 Dec 7.

Department of Ecology and Genetics, Animal Ecology, Uppsala University, Norbyvägen 18D, SE-752 36, Uppsala, Sweden. Electronic address:

The male ejaculate contains a multitude of seminal fluid proteins (SFPs), many of which are key reproductive molecules, as well as sperm. However, the identification of SFPs is notoriously difficult and a detailed understanding of this complex phenotype has only been achieved in a few model species. We employed a recently developed proteomic method involving whole-organism stable isotope labelling coupled with proteomic and transcriptomic analyses to characterize ejaculate proteins in the seed beetle Callosobruchus maculatus. Read More

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December 2018

Comparison of Peripheral Blast Clearance and Day 14 Bone Marrow Biopsy in Predicting Remission Status and Survival After 7+3 Induction in Acute Myeloid Leukemia.

Clin Lymphoma Myeloma Leuk 2018 Nov 12. Epub 2018 Nov 12.

Stem Cell Transplant Program, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH. Electronic address:

Introduction: Induction chemotherapy with cytarabine and an anthracycline (7+3) remains the standard of care for acute myeloid leukemia (AML).

Patients And Methods: We retrospectively analyzed 183 newly diagnosed AML patients to compare the utility of rapid peripheral blast clearance (PBC), day of peripheral blast disappearance, residual blasts, and cellularity at day 14 bone marrow biopsy (D14BM) in predicting clinical response to 7+3 induction, overall survival (OS), and relapse-free survival (RFS).

Results: In multivariable logistic regression analysis, day 2 PBC > 85% [P = . Read More

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November 2018

Distinguishing CPT gene family members and vetting the sequence structure of a putative rubber synthesizing variant in Hevea brasiliensis.

Gene 2018 Dec 4. Epub 2018 Dec 4.

Genome Analysis Laboratory, Rubber Research Institute of India, Rubber Board P O, Kottayam, Kerala PIN-686009, India.

cis-Prenyltransferases (cis-PTs) constitute a large family of enzymes conserved during evolution and present in all domains of life. cis-PTs catalyze the cis-1,4-polymerization of isoprene units to generate isoprenoids with carbon skeletons varying from C10 (neryl pyrophosphate) to C > 10,000 (natural rubber). Though the previously reported CPTs in Hevea are designated based on sequence variations, their classification was done mostly by phylogenetic analysis using a mixture of partial as well as full length sequences often excluding the UTRs. Read More

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December 2018

Consensus map integration and QTL meta-analysis narrowed a locus for yield traits to 0.7 cM and refined a region for late leaf spot resistance traits to 0.38 cM on linkage group A05 in peanut (Arachis hypogaea L.).

BMC Genomics 2018 Dec 7;19(1):887. Epub 2018 Dec 7.

Crops Research Institute, Guangdong Academy of Agricultural Sciences, South China Peanut Sub-Center of National Center of Oilseed Crops Improvement, Guangdong Provincial Key Laboratory of Crop Genetic Improvement, Guangzhou, 510640, China.

Background: Many large-effect quantitative trait loci (QTLs) for yield and disease resistance related traits have been identified in different mapping populations of peanut (Arachis hypogaea L.) under multiple environments. However, only a limited number of QTLs have been used in marker-assisted selection (MAS) because of unfavorable epistatic interactions between QTLs in different genetic backgrounds. Read More

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December 2018

Computer aided Drug Designing for the identification of high affinity small molecule targeting CD20 for the clinical treatment of Chronic Lymphocytic Leukemia (CLL).

Curr Top Med Chem 2018 Dec 10. Epub 2018 Dec 10.

Computer Aided Drug Designing and Molecular Modeling Lab, Department of Bioinformatics, Alagappa University, Karaikudi-630 003, Tamil Nadu. India.

Background: Chronic lymphocytic leukemia (CLL) is a B-lineage lymphoid malignancy of self-reactive cells that are focused to produce polyreactive natural auto antibodies. Its surface protein marker CD20 plays an important role in the humoral immune response, targeting which have emerged as an attractive therapeutic option for the treatment of CLL. The present study explains the interaction of the CD20 with its established inhibitors and to discover the compound having high binding affinity against the target protein receptor. Read More

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December 2018
1 Read

Graft copolymeric flocculant using functionalized starch towards treatment of blast furnace effluent.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Applied Chemistry, Indian Institute of Technology (ISM), Dhanbad 826004, India. Electronic address:

Herein, a novel binary graft copolymeric flocculant [St-g-(PAAm-co-PMETAC)] has been developed using starch, polyacrylamide (PAAm) and poly (2-methacryloyloxy ethyl trimethyl ammonium chloride) (PMETAC). The copolymer has been synthesised by grafting of PAAm and PMETAC chains on starch backbone using free radical polymerization. FTIR and H NMR spectral analyses have been used for structural confirmation of developed copolymer. Read More

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December 2018
3 Reads

Effect of blast-related mTBI on the working memory system: a resting state fMRI study.

Brain Imaging Behav 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA.

Reduced working memory is frequently reported by Veterans with a history of blast-related mild traumatic brain injury (mTBI), but can be difficult to quantify on neuropsychological measures. This study aimed to improve our understanding of the impact of blast-related mTBI on the working memory system by using resting state functional magnetic resonance imaging (fMRI) to explore differences in functional connectivity between OEF/OIF/OND Veterans with and without a history of mTBI. Participants were twenty-four Veterans with a history of blast-related mTBI and 17 Veterans who were deployed but had no lifetime history of TBI. Read More

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December 2018
8 Reads

Divergent evolution of rice blast resistance Pi54 locus in the genus Oryza.

Rice (N Y) 2018 Dec 5;11(1):63. Epub 2018 Dec 5.

Graduate School of Life Sciences, Tohoku University, Sendai, 980-8577, Japan.

Background: The rice blast resistance gene Pi54 was cloned from Oryza sativa ssp. indica cv. Tetep, which conferred broad-spectrum resistance against Magnaporthe oryzae. Read More

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December 2018
2 Reads

The first comprehensive description of the expression profile of genes involved in differential body growth and the immune system of the Jeju Native Pig and miniature pig.

Amino Acids 2018 Dec 5. Epub 2018 Dec 5.

Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju, 690756, Jeju-Do, Republic of Korea.

Sus scrofa provides a major source of animal protein for humans as well as being an excellent biomedical model. This study was carried out to understand, in detail, the genetic and functional variants of Jeju Native Pigs and miniature pigs through differential expression profiling of the genes controlling their immune response, growth performance, and meat quality. The Illumina HiSeq 2000 platform was used for generating 1. Read More

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December 2018
2 Reads

Chemotherapy plus DLI for relapse after haploidentical HSCT: the biological characteristics of relapse influences clinical outcomes of acute leukemia patients.

Bone Marrow Transplant 2018 Dec 5. Epub 2018 Dec 5.

Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.

This study investigated the prognostic factors in patients (n = 89) who experienced relapse and received chemotherapy plus donor leukocyte infusion (Chemo-DLI) after haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Patients with early relapse (< 6 vs. > 6 months after haplo-HSCT), higher bone marrow blast count before chemo-DLI (> 20% vs. Read More

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December 2018
2 Reads

Progressive structural capacity loss assessment-A framework for modern reinforced concrete buildings.

PLoS One 2018 3;13(12):e0208149. Epub 2018 Dec 3.

Department of Civil Engineering, Mirpur University of Sciences and Technology, Mirpur, AJK, Pakistan.

By the virtue of burgeoning terrorism, the exponential growth of advanced weaponry, and allied aids for explosions, it is quite evident that infrastructural facilities in the world have increasingly become more susceptible to sabotaging activities. The ever enhancing employment of reinforced concrete (RC) in the construction industry around the globe, the progressive collapse mechanisms, and respective mitigation strategies in the context of terrorism have garnered quite an attraction by the structural engineering community. The proficiency to envisage the complete collapse under the chain reaction of structural failures, partial collapse of key structural members, or the strength degradation of fundamental structural elements under the blast or impact loading can deliver significant information to cope with partial or complete structural failure. Read More

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December 2018

The clinical significance of the alternative Wilms tumor gene overexpression-hypermethylation signature in acute myeloid leukemia.

Clin Transl Oncol 2018 Nov 30. Epub 2018 Nov 30.

Department of Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background: Wilms tumor 1 (WT1) gene is overexpressed in numerous cancers, including acute myeloid leukemia (AML). The alternative WT1 gene (AWT1) is generated from alternative transcription start site in the WT1 first intron and encodes an N-terminal-truncated protein lacking the repressor domain. Although WT1 overexpression is a common feature in AML, the expression levels of the AWT1 and its underlying epigenetic alterations, as well as their clinical relevance in AML remain unknown. Read More

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November 2018
2 Reads

Label-Free Quantitative Proteomics of Lysine Acetylome Identifies Substrates of Gcn5 in Magnaporthe oryzae Autophagy and Epigenetic Regulation.

mSystems 2018 Nov-Dec;3(6). Epub 2018 Nov 20.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, China.

The rice blast fungus Magnaporthe oryzae poses a great threat to global food security. During its conidiation (asexual spore formation) and appressorium (infecting structure) formation, autophagy is induced, serving glycogen breakdown or programmed cell death function, both essential for pathogenicity. Recently, we identified an M. Read More

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November 2018
3 Reads

Statistical correction for functional metagenomic profiling of a microbial community with short NGS reads.

J Appl Stat 2018 27;45(14):2521-2535. Epub 2018 Jan 27.

Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, USA.

By sequence homology search, the list of all the functions found and the counts of reads being aligned to them present the functional profile of a metagenomic sample. However, a significant obstacle has been observed in this approach due to the short read length associated with many next generation sequencing technologies. This includes artificial families, cross-annotations, length bias and conservation bias. Read More

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January 2018

Managing myelofibrosis (MF) that "blasts" through: advancements in the treatment of relapsed/refractory and blast-phase MF.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):118-126

Mays Cancer Center, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX.

Myelofibrosis (MF) is the most aggressive form of Philadelphia chromosome-negative myeloproliferative neoplasm, and it is complicated by severe symptom burden, thrombotic events, infections, cytopenias, and transformation to acute myeloid leukemia (AML). Ruxolitinib, the first-line therapy for symptomatic or intermediate- and high-prognostic risk MF, has improved overall survival for this population. However, approximately one-half of MF patients will discontinue ruxolitinib by the first few years of therapy due to a spectrum of resistance, intolerance, relapse, or progression to blast phase disease. Read More

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November 2018
1 Read

Antibody-based therapies in patients with acute lymphoblastic leukemia.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):9-15

Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.

The use of multiagent combination chemotherapy regimens results in cure rates of >90% for children and ∼40% for adults with acute lymphoblastic leukemia (ALL) but is associated with extensive toxicity and disappointingly low efficacy in relapsed patients. ALL blast cells express several surface antigens, including CD20, CD22, and CD19, which represent valuable targets for immunotherapy. Monoclonal antibodies, antibody-drug conjugates, and bispecific T-cell-engaging antibodies targeting these antigens offer novel mechanisms of action. Read More

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November 2018
2 Reads

Somatic Mutations in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.

Semin Hematol 2018 Oct 17;55(4):215-222. Epub 2018 Apr 17.

Serviço de Hematologia e Transplantação de Medula, Hospital de Santa Maria, Lisboa, Portugal.

Myeloproliferative neoplasms (MPN) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). MPN are characterized by clonal proliferation of myeloid progenitors leading to erythrocytosis, thrombocytosis, or leukocytosis, and risk of hemorrhagic and thrombotic events, as well as myelofibrosis and blast transformation. The discovery of somatic mutations in MPN, namely JAK2 V617F, JAK2 exon 12, MPL, and CALR mutations, has permitted a more specific approach to diagnosis and treatment. Read More

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October 2018
2 Reads

Bone Marrow Fibrosis and Early Hematological Response as Predictors of Poor Outcome in Azacitidine Treated High Risk-Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia.

Semin Hematol 2018 Oct 21;55(4):202-208. Epub 2018 Feb 21.

Hematology department, Hematology Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy.

Azacitidine (AZA) treatment is effective treatment for patients with myeloid disorders, and factors predictive of treatment outcome are under investigation. Little is known about the effect of bone marrow fibrosis on response to AZA therapy. We, retrospectively, evaluated clinical predictors of overall survival (OS) and overall response rate (ORR) for patients treated with AZA in a real-life cohort. Read More

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October 2018
1 Read

[Efficacy of Decitabine Combined with Pre-Excitation Chemotherapy in the Treatment of Middle-Aged and Elderly MDS Transformed Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1713-1718

Department of Internal Medicine, The People's Hospital of Renhua County, Shaoguan 512300, Guangdong Province, China.

Objective: To investigate the efficacy of domestic decitabine (D) combined with pre-excitation chemotherapy consisted of Ara-c, THP and G-CSF(CTG) in treatment of middle-aged and elderly patients with MDS-transformed AML and prognosis-related factors.

Methods: Seventy-six patients with MDS-transformed AML treated in our hospital from June 2013 to June 2015 were selected according to treatment regimens, 76 patients were divided into 2 groups: CTG group(36 cases) and D+CTG group(40 cases). The patients in CTG group received treatment with Ara-C, THP and G-CSF; the patients received the treatment with decitabine plus CTG. Read More

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December 2018
1 Read

[Clinical Significance of Additional Chromosomal 8 Clonal Evolution in CML Progression].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1598-1603

Department of Hematology, Affiliated Hospital; Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Pro- vince, ChinaE-mail:

Objectives: To explore the clinical significance of clonal evolution of additional chromosomal 8 in CML progression.

Methods: An unusual case with the clonal evolution from trisomy 8 to tetrasomy 8 accompanied by 2 time of CML blast crisis (BC) was reported.

Results: This patient suffered from 2 time of CML blast crisis and the additional chromosome 8 aberrations were accompanied. Read More

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December 2018

Comprehensive Characterization of Cerebrovascular Dysfunction in Blast Traumatic Brain Injury Using Photoacoustic Microscopy.

J Neurotrauma 2018 Dec 1. Epub 2018 Dec 1.

University of Virginia, Biomedical Engineering, Charlottesville, Virginia, United States ;

Blast traumatic brain injury (bTBI) is a leading contributor to combat-related injuries and death. Although substantial emphasis has been placed on blast-induced neuronal and axonal injuries, co-existing dysfunctions in the cerebral vasculature, particularly the microvasculature, remain poorly understood. Here, we studied blast-induced cerebrovascular dysfunctions in a rat model of bTBI (blast overpressure: 187. Read More

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December 2018
3 Reads
3.714 Impact Factor

Dynamic insertion of Pot3 in AvrPib prevailing in a field rice blast population in the Philippines led to the high virulence frequency against the resistance gene Pib in rice.

Phytopathology 2018 Dec 3. Epub 2018 Dec 3.

International Rice Research Institute , DAPO box 7777, Metro Manila , Manila, Philippines , 4031 ;

The Magnaporthe oryzae avirulence gene AvrPib is required for the resistance mediated by its cognate resistance (R) gene Pib which has been intensively used in indica rice breeding programs in many Asian countries. However, the sequence diversity of AvrPib among geographically distinct M. oryzae populations was recently shown to be increasing. Read More

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December 2018
2 Reads

Differential expression profiles and functional analysis of plasma miRNAs associated with chronic myeloid leukemia phases.

Future Oncol 2018 Dec 3. Epub 2018 Dec 3.

Molecular Biology Research Center, School of Life Sciences, Central South University, Changsha 410078, PR China.

Aim: This study was aimed to investigate the expression profiles and biological function of plasma miRNAs at different phases of chronic myeloid leukemia (CML).

Materials & Methods: Differentially expressed miRNAs were identified by microarray. The candidate miRNAs were validated by quantitative real-time PCR at chronic phase, accelerated phase and blast crisis. Read More

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December 2018

Distribution characteristics of combat-related shrapnel and relationship to weapon type and conflict location: Experience of an operational field hospital.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):587-593

Department of Radiology, Dr. Aşkım Tüfekçi State Hospital, Adana-Turkey.

Background: The aim of this study was to investigate the characteristics of shrapnel distribution in the body and a possible relationship to the type of weapon and type of location of the conflict.

Methods: The records of 246 patients admitted to a level-III trauma center with any kind of firearm injury were examined retrospectively. Ninety patients who had at least 1 radiologically-proven piece of shrapnel in their body were included in the study. Read More

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November 2018

Quantifying the association between acute leukemia and serum zinc, copper, and selenium: a meta-analysis.

Leuk Lymphoma 2018 Dec 5:1-9. Epub 2018 Dec 5.

b University of Texas at Austin College of Education , Educational Psychology , Austin , TX , USA.

Acute leukemia is a clonal malignant disorder that occurs when immature blast cells accumulate in bone marrow. Zinc (Zn) and copper (Cu) are related to normal lymphocyte maturation and immune function regulation. Selenium (Se) is protective against oxidative damage. Read More

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December 2018