Search Our Scientific Publications & Authors

Ann Diagn Pathol 2021 Jun 5;53:151767. Epub 2021 Jun 5.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.

The t(9;22)(q34;q11.2), also known as the Philadelphia (Ph) chromosome, results in BCR-ABL1 fusion residing on the derivative chromosome 22. This translocation is characteristic of chronic myeloid leukemia, but also can occur in a substantial subset of B acute lymphoblastic leukemia (B-ALL) cases. Read More

Mol Plant Pathol 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.

Polar growth during appressorium formation is vital for the penetration peg formation in the rice blast fungus, Magnaporthe oryzae. Previous research has shown that the Sln1-septin-exocyst complex, localized at the base of the appressorium in contact with the leaf surface, forms a ring structure that influences growth polarity and affects penetration peg formation, and is necessary for pathogenicity. Our previous research showed CK2 proteins assemble another ring structure positioned perpendicular to the Sln1-septin-exocyst complex. Read More

Ann Biomed Eng 2021 Jun 11. Epub 2021 Jun 11.

Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD, 20723, USA.

The lower extremity is the most frequently injured body region to mounted soldiers during underbody blast (UBB) events. UBB events often produce large deformations of the floor and subsequent acceleration of the lower limb that are not sufficiently mitigated by the combat boot, leaving the calcaneus bone vulnerable to injury. Biomechanical experiments simulating UBB loading scenarios were conducted in a laboratory environment using isolated postmortem human subject (PMHS) leg components. Read More

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Division of Trauma and Acute Care Surgery, Unity Health Toronto, Toronto, Ontario, Canada

Oesophageal perforation is a serious condition associated with significant morbidity and mortality. Clinical suspicion of oesophageal injury in patients sustaining neck or torso trauma is essential as early diagnosis and management are associated with better outcomes. Oesophageal perforation resulting from blunt trauma is uncommon, and traumatic oesophageal perforation following blast injury is exceedingly rare. Read More

Pest Manag Sci 2021 Jun 11. Epub 2021 Jun 11.

Fuzhou Institute of Oceanography, Minjiang University, Fuzhou, 350108, China.

Background: Sanguinarine (SAN) is a benzophenanthridine alkaloid that broadly targets a range of pathways in mammalian and fungal cells. In this study we set to explore the molecular mechanism how sanguinarine inhibits fungal development and pathogenicity of Magnaporthe oryzae with the hope that sanguinarine will bolster the development of anti-blast agents.

Results: We found that the fungus exhibited a significant reduction in the vegetative growth and hyphal melanization while the spores produced long germ tubes on the artificial hydrophobic surface characteristic of a defect in thigmotropic sensing when exposed to 4 μM, 8 μM and 0. Read More

Leuk Res 2021 Jun 6;109:106638. Epub 2021 Jun 6.

Department of Hematology, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Henan, People's Republic of China. Electronic address:

Cytoplasmic vacuoles, which are a morphological feature of dysplasia, can be observed under a microscope at initial diagnosis. Recently, this typical morphological feature has been found to be associated with impaired survival. To investigate the clinical significance of the grading of blasts with vacuoles in acute myeloid leukemia (AML), we retrospectively studied 152 patients newly diagnosed with non-M3 AML. Read More

Int J Lab Hematol 2021 Jun 11. Epub 2021 Jun 11.

Department of Hematology, SGPGIMS, Lucknow, India.

Objective: To assess the prevalence of early T precursor-acute lymphoblastic leukaemia (ETP-ALL), study its clinicopathological features and devise a 'flow score' based on immunophenotypic profiles.

Material Methods: This was a retrospective study where clinical and laboratory data of all consecutive T-ALL cases were analysed to identify features differentiating ETP from non-ETP-ALL. The utility of a flow score based on the five commonly used markers in leukaemia panels for T-ALL (CD34, CD8, CD5, CD13 and CD33) was evaluated to differentiate ETP from non-ETP-ALL. Read More

Acta Parasitol 2021 Jun 11. Epub 2021 Jun 11.

Toxoplasmosis Research Center, Communicable Diseases Institute, Iranian National Registry Center for Lophomoniasis (INRCL), Mazandaran University of Medical Sciences, Farah-Abad Road, P.O Box: 48471- 91971, Sari, Iran.

Background: In the last decade, several cases of bronchopulmonary lophomoniasis (BPL) have been recorded. Little information is available about epidemiological aspects on Lophomonas infection among BPL patients. The present study was aimed to investigate the prevalence of Lophomonas spp. Read More

Mil Med 2021 Jun 11. Epub 2021 Jun 11.

National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD 20889-5649, USA.

Introduction: Post-traumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are common conditions among military personnel that frequently co-occur. This study investigated relationships between self-reported blast exposure, mTBI history, and current post-traumatic stress (PTS) symptoms in a population of active duty service members (n = 202) from the Intensive Outpatient Program at the National Intrepid Center of Excellence.

Materials And Methods: Participants were divided into four mTBI groups (0, 1, 2, and 3+) and four blast exposure groups (0-10, 11-100, 101-1,000, and 1,000+). Read More

BMC Bioinformatics 2021 Jun 10;22(1):317. Epub 2021 Jun 10.

Univ Rennes, Inria, CNRS, IRISA, Rennes, France.

Background: To assign structural and functional annotations to the ever increasing amount of sequenced proteins, the main approach relies on sequence-based homology search methods, e.g. BLAST or the current state-of-the-art methods based on profile Hidden Markov Models, which rely on significant alignments of query sequences to annotated proteins or protein families. Read More

Hand Surg Rehabil 2021 Jun 7. Epub 2021 Jun 7.

Service d'Orthopédie, de Traumatologie, de Chirurgie Plastique, Reconstructrice et Assistance Main, CHU de Besançon, 3 Boulevard Alexandre Fleming, 25030 Besançon, France; Université de Bourgogne Franche-Comté, Sciences Médicales et Pharmaceutiques, 19 Rue Ambroise Paré, 25030 Besançon, France; Nanomédecine, Imagerie, Thérapeutique-EA 4662, Université de Bourgogne Franche-Comté, Sciences Médicales et Pharmaceutiques, 19 Rue Ambroise Paré, 25030 Besançon, France.

The objective of this work was to assess whether the injury mechanisms are responsible for histological arterial lesions. This prospective single-center study included adults with wrist or hand arterial injury. Arterial resection of at least 2 mm from the proximal and distal stumps was performed before the arterial anastomosis. Read More

Blood 2021 Jun 10. Epub 2021 Jun 10.

University Hospital Ulm, Ulm, Germany.

Patients with acute myeloid leukemia (AML) have conventionally received more "intense" therapy than patients with myelodysplastic syndromes (MDS). Although less intense therapies are being used more often in AML, the AML-MDS dichotomy remains, with the presence of ≥ 20% myeloblasts in marrow or peripheral blood generally regarded as defining AML. Consequently, patients with 19% blasts are typically ineligible for AML studies, with patients with 21% blasts ineligible for MDS studies. Read More

Blood 2021 Jun 10. Epub 2021 Jun 10.

University of Edinburgh, Edinburgh, United Kingdom.

t(4;11) MLL-AF4 acute leukemia is one of the most aggressive malignancies in the infant and pediatric population, yet we have little information on the molecular mechanisms responsible for disease progression. This impairs the development of therapeutic regimens that can address the aggressive phenotype and lineage plasticity of MLL-AF4-driven leukemogenesis. This study highlights novel mechanisms of disease development by focusing on two microRNAs upregulated in leukemic blasts from primary patient samples: miR-130b and miR-128a. Read More

Blood 2021 Jun;137(23):3310

Princess Alexandra Hospital.

Nat Cancer 2020 Apr 20;1(4):410-422. Epub 2020 Apr 20.

Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla, CA, USA.

Aggressive myeloid leukemias such as blast crisis chronic myeloid leukemia and acute myeloid leukemia remain highly lethal. Here we report a genome-wide in vivo CRISPR screen to identify new dependencies in this disease. Among these, RNA-binding proteins (RBPs) in general, and the double-stranded RBP Staufen2 (Stau2) in particular, emerged as critical regulators of myeloid leukemia. Read More

Sci Rep 2021 Jun 9;11(1):12222. Epub 2021 Jun 9.

Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.

Although numerous metagenome, amplicon sequencing-based studies have been conducted to date to characterize marine microbial communities, relatively few have employed full metagenome shotgun sequencing to obtain a broader picture of the functional features of these marine microbial communities. Moreover, most of these studies only performed sporadic sampling, which is insufficient to understand an ecosystem comprehensively. In this study, we regularly conducted seawater sampling along the northeastern Pacific coast of Japan between March 2012 and May 2016. Read More

Ear Hear 2021 Jun 8. Epub 2021 Jun 8.

Audiology and Speech Pathology Center, Walter Reed National Military Medical Center, Bethesda, Maryland, USA Rehabilitation Research & Development Services, U.S. Department of Veterans Affairs, Washington DC, USA 2GaRi Solutions INC, Aguada, Puerto Rico.

Objectives: Over the past decade, U.S. Department of Defense and Veterans Affairs audiologists have reported large numbers of relatively young adult patients who have normal to near-normal audiometric thresholds but who report difficulty understanding speech in noisy environments. Read More

Rinsho Ketsueki 2021 ;62(5):346-351

Department of Hematology/Oncology, Saitama Children's Medical Center.

A 14-year-old male with autism was admitted to our hospital owing to altered consciousness and gait disturbance. Blood tests showed a white blood cell (WBC) count of 728,600/µl, and brain computed tomography revealed intracranial hemorrhage and a midline shift of the brain. The chronic phase of chronic myeloid leukemia (CML) was confirmed as per bone marrow aspiration findings. Read More

AIDS Res Hum Retroviruses 2021 Jun 9. Epub 2021 Jun 9.

Gansu Provincial Center for Disease Control and Prevention, Lanzhou, China;

Objectives: It is important to monitor the diversity and evolution of HIV-1 genotypes especially in some remote and undeveloped regions in China where the diversity and distribution of HIV-1 genotypes are not fully clear.

Methods: To investigate the genotypes and distribution of HIV-1 in far Northwestern Gansu Province of China, we selected 220 HIV-1 positive plasma samples from the center of disease prevention and control (CDC) in Gansu from January 2016 to December 2018. The viral load of inclusion samples were over 1000 copies per milliliter. Read More

J Environ Manage 2021 Jun 6;293:112944. Epub 2021 Jun 6.

Hiroshima Prefectural Agriculture, Forestry and Fisheries Bureau, Hiroshima Prefecture, 10-52, Motomachi, Naka-ku, Hiroshima, 730-8511, Japan.

To promote primary production in oligotrophic seas, we developed a fertilization composite consisting of blast furnace cement and anaerobic digestate with a high nutrient content derived from biogas power plant byproducts. In this study, we investigated the dissolution behavior of nutrients from the fertilization composite and evaluated the effects of the fertilization composite on the growth of marine primary producers. Batch experiments and tank experiments to simulate oligotrophic coastal seas revealed that the nutrients dissolved from the fertilization composite were taken up by marine microalgae and seaweed. Read More

Bioinformatics 2021 Jun;37(9):1206-1210

Department of Computer Science, University of Western Ontario, London, ON N6A 5B7, Canada.

Motivation: Sequence similarity is the most frequently used procedure in biological research, as proved by the widely used BLAST program. The consecutive seed used by BLAST can be dramatically improved by considering multiple spaced seeds. Finding the best seeds is a hard problem and much effort went into developing heuristic algorithms and software for designing highly sensitive spaced seeds. Read More

Int J Syst Evol Microbiol 2021 Jun;71(6)

Actinobacterial Research Unit, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

An endophytic actinobacterium, designated strain CA1R205, was isolated from the surface-sterilized root of L. collected from Ratchaburi province, Thailand. The taxonomic position of this strain was evaluated using a polyphasic approach. Read More

Invest Ophthalmol Vis Sci 2021 Jun;62(7):13

Department of Ophthalmology and Visual Sciences, Carver College of Medicine, The University of Iowa, Iowa City, IA, United States.

Purpose: The purpose of this study was to examine the influence of genetic background on the retinal ganglion cell (RGC) response to blast-mediated traumatic brain injury (TBI) in Jackson Diversity Outbred (J:DO), C57BL/6J and BALB/cByJ mice.

Methods: Mice were subject to one blast injury of 137 kPa. RGC structure was analyzed by optical coherence tomography (OCT), function by the pattern electroretinogram (PERG), and histologically using BRN3A antibody staining. Read More

Braz J Biol 2021 2;82:e240725. Epub 2021 Jun 2.

Department of Zoology, University of the Punjab, Lahore, Pakistan.

Molecular based identification of bat fauna in Pakistan has been relatively less explored. The current study was therefore planned to report for the first time the molecular classification of insectivorous bats (Pipistrellus coromandra) based on mitochondrion gene (COI) from Punjab, Pakistan. Specimens were collected from five different locations followed by DNA extraction with subsequent gene amplification and sequencing. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):840-846

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China,E-mail:

Objective: To investigate the clinical characteristics and prognosis of patients with medium and high risk myelodysplastic syndrome (MDS).

Methods: 97 MDS patients above the age of 60 treated in Nanfang Hospital, Southern Medical University from February 2011 to August 2020 were enrolled. The clinical characteristics and prognosis of the MDS patients with medium risk, high risk or very high risk based on IPSS-R category were retrospectively analyzed. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):832-839

Department of Hematology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China,E-mail:

Objective: To investigate the quantitative expression of immunophenotype of CD34 myeloid precursor cells in myelodysplastic syndrome (MDS) patients and its correlation with clinical characteristics, and understand the effect of quantitative expression of CD7 and CD117 on the prognosis of low-risk MDS patients.

Methods: Multi-parameter flow cytometry (FCM) was used to detect the proportion and mean fluorescence intensity (MFI) of each antigen of bone marrow CD34 myeloid precursor cells in 79 MDS patients. The correlation between the expression level of each immune marker and clinical characteristics was compared. Read More

Plant Dis 2021 Jun 9. Epub 2021 Jun 9.

University of Mysore, 29243, Applied Botany and Biotechnology, Mysore, Karnataka, India;

Pearl millet (Cenchrus americanus L.) field-grown plants of cv. 7042S shown unusual water-soaked lesions on leaf tips spreading towards the leaf base from Manasagangothri region (12. Read More

Plant Dis 2021 Jun 9. Epub 2021 Jun 9.

National Pesticide Engineering Research Center, Nankai University, Tianjin, Tianjin, Tianjin, China, 300071;

Kalanchoe pinnata (Lam.) Pers. [syn. Read More

Plant Physiol Biochem 2021 May 28;166:128-139. Epub 2021 May 28.

National Agri-Food Biotechnology Institute (NABI), Mohali, India. Electronic address:

Rice blast caused by Magnaporthe oryzae and sheath blight caused by Rhizoctonia solani, are the two major diseases of rice that cause enormous losses in rice production worldwide. Identification and utilization of broad-spectrum resistance resources have been considered sustainable and effective strategies. However, the majority of the resistance genes and QTLs identified have often been found to be race-specific, and their resistance is frequently broken down due to continuous exposure to the pathogen. Read More

Blood Adv 2021 Jun;5(11):2539-2549

Department of Pathology, UT Southwestern Medical Center, Dallas, TX.

The clinicopathologic features of DNA methyltransferase 3A (DNMT3A)-mutated de novo acute myeloid leukemia (AML), and the significance of variant type, variant allele frequency (VAF), and multiple concomitant DNMT3A mutations, remain poorly defined. We examined 104 DNMT3A-mutated de novo AML patients from 2 major centers. Most (82%) had normal karyotype (NK); R882H variants were frequent(38%). Read More