178,605 results match your criteria Bladder cancer Amsterdam Netherlands[Journal]


Assessment of Intermittent Self-Catheterization Procedures in Patients with Neurogenic Lower Urinary Tract Dysfunction: Dutch Translation and Validation of the Intermittent Catheterization Satisfaction Questionnaire, Intermittent Catheterization Acceptance Test, Intermittent Self Catheterization Questionnaire and Intermittent Catheterization Difficulty Questionnaire.

Urol Int 2019 Apr 18:1-6. Epub 2019 Apr 18.

Department of Urology, Ghent University Hospital, Ghent, Belgium.

Background: Intermittent self-catheterization (ISC) is by far the most appealing therapy to achieve a complete bladder emptying in patients with neurogenic lower urinary tract dysfunction (NLUTD). Four questionnaires have been developed in French in order to assess patient's satisfaction, difficulties and acceptance of this technique.

Objectives: The aim of this study was to translate, culturally adapt and validate Dutch versions of the Intermittent Catheterization Satisfaction Questionnaire (InCaSaQ), the Intermittent Catheterization Acceptance Test (ICAT), the Intermittent Self Catheterization Questionnaire (ISCQ) and the Intermittent Catheterization Difficulty Questionnaire (ICDQ). Read More

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http://dx.doi.org/10.1159/000499884DOI Listing

High soluble CGA levels are associated with poor survival in bladder cancer.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

H Reis, Institute of Pathology , University of Essen-Duisburg, Essen, Germany.

Recently, a neuroendocrine-like molecular subtype has been discovered in muscle-invasive urothelial bladder cancer (BC). Chromogranin A (CGA) is a widely used tissue and serum marker in neuroendocrine tumors. Our aim was to evaluate serum CGA (sCGA) concentrations and their associations with clinical and follow-up data in BC and renal cell carcinoma (RCC). Read More

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https://ec.bioscientifica.com/view/journals/ec/aop/ec-19-006
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http://dx.doi.org/10.1530/EC-19-0068DOI Listing
April 2019
2 Reads

UCA1 promotes cell viability, proliferation and migration potential through UCA1/miR-204/CCND2 pathway in primary cystitis glandularis cells.

Biomed Pharmacother 2019 Apr 15;114:108872. Epub 2019 Apr 15.

Reproductive Medicine Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China. Electronic address:

Cystitis glandularis (CG) is an unusual proliferative disorder of the urinary bladder. Increasing evidences demonstrated that long non-coding RNAs (lncRNAs) play important roles in a variety of cellular progresses. However, there are rarely reports about the role and underlying molecular mechanism of lncRNAs in CG. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108872DOI Listing

Computational identification of RNA-Seq based miRNA-mediated prognostic modules in cancer.

IEEE J Biomed Health Inform 2019 Apr 16. Epub 2019 Apr 16.

Systematic identification of miRNA prognostic signature can help decipher the effects of biomarkers in cancer treatment. A number of previous studies have only characterized a single miRNA as a promising prognostic biomarker. There is currently a trend towards combining several miRNAs as a panel of prognostic signatures, but few attempt to explain the mechanism of miRNA combination. Read More

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http://dx.doi.org/10.1109/JBHI.2019.2911528DOI Listing

Intravesical electromotive administration of botulinum toxin type A in improving the bladder and bowel functions: Evidence for novel mechanism of action.

J Spinal Cord Med 2019 Apr 18:1-7. Epub 2019 Apr 18.

b Department of pathology , Shariati Hospital, Tehran University of Medical Sciences , Tehran , Iran.

Objective: To examine the hypothesis that what is the concomitant mechanism of action botulinum toxin type A (BoNTA) administration by intravesical electromotive into the bladder resulting in bladder function improvement. We also tried to confirm the possibility of retrograde trans-axonal transportation of toxin.

Design: Animal study. Read More

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http://dx.doi.org/10.1080/10790268.2019.1603490DOI Listing

Feasibility and outcomes: Pilot Randomized Controlled Trial of a home-based integrated physical exercise and bladder-training program vs usual care for community-dwelling older women with urinary incontinence.

Neurourol Urodyn 2019 Apr 18. Epub 2019 Apr 18.

Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.

Aims: To assess the feasibility of a randomized controlled trial of a home-based integrated physical exercise and bladder-training program vs usual care in community-dwelling women with urinary incontinence (UI).

Methods: We conducted a parallel arm, nonblinded, pilot randomized controlled trial of a home-based integrated physical exercise and bladder training with urge suppression and fall prevention program (ExerciseUP) vs usual care in women aged 65 and older with UI. Outcomes included feasibility (process, resources, management, and acceptability), urinary symptoms, and falls risk using self-administered questionnaires. Read More

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http://dx.doi.org/10.1002/nau.23999DOI Listing

Age and sex have no impact on expression levels of markers of immune cell infiltration and immune checkpoint pathways in patients with muscle-invasive urothelial carcinoma of the bladder treated with radical cystectomy.

Cancer Immunol Immunother 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Objectives: Advanced age and female sex have been associated with worse outcomes in patients undergoing radical cystectomy for muscle-invasive bladder cancer. A reduced immune response has been implicated as a mechanism. The objective of our study was to analyze the expression patterns of various cellular proteins active in bladder cancer immune pathways, and assess the correlation between age, sex, and the expression of these immune markers. Read More

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http://link.springer.com/10.1007/s00262-019-02340-w
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http://dx.doi.org/10.1007/s00262-019-02340-wDOI Listing
April 2019
1 Read

Challenges in urogenital tuberculosis.

World J Urol 2019 Apr 17. Epub 2019 Apr 17.

Novosibirsk Research TB Institute, Urogenital Clinic, Novosibirsk, Russian Federation.

Purpose: For better understanding of urogenital tuberculosis (UGTB), its clinical spectrum and characteristic features need to be evaluated.

Materials And Methods: One hundred and forty-two cases of UGTB patients were analyzed retrospectively. We considered age, gender, symptoms, and diagnostic procedures. Read More

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http://dx.doi.org/10.1007/s00345-019-02767-xDOI Listing

Favorable Outcome in a Patient with Systemic BCGitis After Intra-bladder Instillation of Calmette-Guerin Bacillus Highlighting the Importance of Making the Correct Diagnosis in this Rare Form of Sepsis.

J Transl Int Med 2019 Mar 29;7(1):34-38. Epub 2019 Mar 29.

Intensive Care Department, Brugmann University Hospital, Brussels Belgium.

We present the case of a patient with sepsis following a traumatic intra-bladder instillation of Calmette-Guerin Bacillus with pneumonia and possibly hepatitis. These complications are rare and could be induced by both immuno-allergic reaction and bacteremia. There is no specific guideline to treat this condition, but many clinicians depicting similar cases seem to agree on prolonged anti-tuberculous antibiotics with associated corticosteroid therapy. Read More

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http://dx.doi.org/10.2478/jtim-2019-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463824PMC

Management of Patients with Liver Cirrhosis and Invasive Bladder Cancer: A Case-series.

J Transl Int Med 2019 Mar 29;7(1):29-33. Epub 2019 Mar 29.

Department of Urology, School of Medicine, University of Thessaly, Larissa, Greece.

Liver cirrhosis is a major risk factor for increased mortality and morbidity in patients undergoing non-hepatic surgery with overall mortality rates as high as 45-50%. However, cirrhotic patients are often in need of surgical procedures including urological surgeries like cystectomies for muscle invasive bladder cancer. Data on the prognosis of these patients undergoing cystectomy for bladder cancer are scarce in the literature. Read More

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http://content.sciendo.com/view/journals/jtim/7/1/article-p2
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http://dx.doi.org/10.2478/jtim-2019-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463823PMC
March 2019
1 Read

[Comparison of effectiveness and complications between two different methods of augmentation cystoplasty].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):293-297

Department of Urology, Peking University People's Hospital, Beijing 100044, China.

Objective: To compare the effectiveness and complications between enterocystoplasty and small intestinal submucosa (SIS) cystoplasty through follow-ups of patients with augmentation cystoplasty in Peking University People's Hospital, offering alternative approach for future treatment.

Methods: In this study, retrospective analyses were carried out in 10 patients who underwent enterocystoplasty or SIS cystoplasty in Peking University People's Hospital from November 2011 to December 2016. Clinical data were collected including medical history, surgical procedures, laboratory examinations and complications. Read More

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Which patients with ischaemic priapism require further investigation for malignancy?

Int J Impot Res 2019 Apr 17. Epub 2019 Apr 17.

Andrology Department, University College, 47 Wimpole St, London, W1G 8PH, UK.

Ischaemic priapism (IP) is characterised by a persistent, painful penile erection lasting for >4 h. Many causes of IP have been identified including haematological dyscrasias (particularly, sickle cell disease), drugs and rarely malignancy. There are also a large proportion of men, in which no aetiology is identified. Read More

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http://dx.doi.org/10.1038/s41443-019-0141-zDOI Listing

tRNA Fragments Show Intertwining with mRNAs of Specific Repeat Content and Have Links to Disparities.

Cancer Res 2019 Apr 17. Epub 2019 Apr 17.

Computational Medicine Center, Thomas Jefferson University

tRNA-derived fragments (tRFs) are a class of potent regulatory RNAs. We mined the datasets from The Cancer Genome Atlas representing 32 cancer types with a deterministic and exhaustive pipeline for tRNA fragments. We found that mitochondrial tRNAs contribute disproportionally more tRFs than the nuclear ones. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0789DOI Listing

Effects of Intraoperative Nefopam on Catheter-Related Bladder Discomfort in Patients Undergoing Robotic Nephrectomy: A Randomized Double-Blind Study.

J Clin Med 2019 Apr 16;8(4). Epub 2019 Apr 16.

Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Gyeonggi-do 15355, Korea.

Catheter-related bladder discomfort (CRBD) is one of the most difficult symptoms during the postoperative period. Nefopam is a non-narcotic analgesic agent, which also has anticholinergic action. This study was performed to evaluate the effects of nefopam on CRBD in male patients undergoing robotic nephrectomy. Read More

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http://dx.doi.org/10.3390/jcm8040519DOI Listing

Functional effects of blocking VEGF/VEGFR2 signaling in the rat urinary bladder in acute and chronic CYP-induced cystitis.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Neurological Sciences, University of Vermont, United States.

High expression of vascular endothelial growth factor (VEGF) is associated with immature angiogenesis within the urinary bladder wall and bladder afferent nerve sensitization leading to visceral hyperalgesia and pelvic pain. Research suggests a shift in VEGF alternative splice variant (VEGF-Aa, VEGF-Ab) expression with several pathologies (e.g. Read More

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http://dx.doi.org/10.1152/ajprenal.00083.2019DOI Listing

Detection and Characterization of Atypical Renal Cysts and Solid Renal Masses in Kidney Transplant Patients by Use of Dual-Energy CT Iodine Maps.

AJR Am J Roentgenol 2019 Apr 17:1-8. Epub 2019 Apr 17.

1 Department of Radiology, Amiens University Hospital, Ave Rene Laennec, Amiens, France 80054.

The purpose of this study was to evaluate whether dual-energy CT follow-up of kidney transplant recipients performed with only two contrast-enhanced phases and reconstructed material maps has the same diagnostic efficiency as triphasic conventional CT in detection and characterization of atypical renal cysts and renal masses. In a retrospective study, 175 renal transplant patients underwent dual-energy CT as part of their follow-up (monoenergetic unenhanced, late contrast-enhanced, and tubular contrast-enhanced dual-energy phases). An unenhanced virtual series and material separation maps were reconstructed. Read More

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http://dx.doi.org/10.2214/AJR.18.20574DOI Listing

Ultrasound-guided placement of pigtail cystostomy tubes in dogs with urethral obstruction.

J Vet Emerg Crit Care (San Antonio) 2019 Apr 17. Epub 2019 Apr 17.

College of Veterinary Medicine, North Carolina State University, Raleigh, NC.

Background: Circumstances such as the inability to pass a retrograde urinary catheter or a lack of surgeon availability may prevent immediate relief of urethral obstruction in dogs. In such situations, a cystostomy tube may be placed with ultrasound guidance to allow urinary diversion until further treatment is possible.

Key Findings: A case of a 5-year-old male neutered Swiss Mountain dog with an obstructive urolith at the level of the os penis is used to describe the technique. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/vec.12832
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http://dx.doi.org/10.1111/vec.12832DOI Listing
April 2019
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Selective use of cystogram following segmental bowel resection in patients with enterovesical fistula.

Colorectal Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands.

Introduction: Patients undergoing resectional surgery for enterovesical fistulas generally have an in-dwelling urinary catheter postoperatively to prevent a recurrent fistula. The aim of this study was to assess the place of a postoperative cystogram after such surgery, when it should be performed and for how long the bladder should be drained after surgery.

Methods: A retrospective single centre study of all patients undergoing ileocaecal or sigmoid resection for surgery for enterovesical fistula with the primary endpoint of recurrent urinary fistula. Read More

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http://dx.doi.org/10.1111/codi.14652DOI Listing

The utility of vaginal erbium: YAG laser in the treatment of overactive bladder syndrome is in need of confirmation.

Authors:
Senol Tonyali

World J Urol 2019 Apr 16. Epub 2019 Apr 16.

Turkiye Yuksek Ihtisas Training and Research Hospital Department of Urology, University of Health Sciences, Altındag, 06230, Ankara, Turkey.

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http://dx.doi.org/10.1007/s00345-019-02694-xDOI Listing

Diagnostic ureteroscopy prior to nephroureterectomy for urothelial carcinoma is associated with a high risk of bladder recurrence despite technical precautions to avoid tumor spillage.

World J Urol 2019 Apr 16. Epub 2019 Apr 16.

Department of Urology and Renal Transplantation, La Conception University Hospital, APHM, Aix-Marseille University, 13005, Marseille, France.

Purpose: There have recent reports in the literature of increased rates of bladder recurrence (BR) after radical nephroureterectomy (RNU) when diagnostic flexible ureteroscopy (DFU) was performed before RNU. The technical heterogeneity of DFU was a major bias in these studies. Our purpose was to evaluate the impact of a standardized DFU technique before RNU on the risk of BR. Read More

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http://dx.doi.org/10.1007/s00345-019-02768-wDOI Listing

Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor.

World J Urol 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.

Background: Basophils, eosinophils and monocytes may be involved in BCG-induced immune responses and be associated with outcomes of bladder cancer patients receiving intravesical BCG. Our objective was to explore the association of baseline counts of basophils, eosinophils and monocytes with outcomes of patients with high-grade T1 bladder cancer receiving a standard course of intravesical BCG.

Methods: We retrospectively reviewed medical records of patients with primary T1 HG/G3 bladder cancer. Read More

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http://dx.doi.org/10.1007/s00345-019-02754-2DOI Listing

Postoperative Urinary Retention After Laparoscopic Colorectal Resection with Early Catheter Removal: A Prospective Observational Study.

World J Surg 2019 Apr 16. Epub 2019 Apr 16.

Colorectal Cancer Unit, Department of Surgery, Zealand University Hospital, Roskilde, Sygehusvej 10, 4000, Roskilde, Denmark.

Background: Early catheter removal is essential to enhance postoperative mobilization and recovery, but may carry a risk of urinary retention. This study aimed to evaluate a standardized regimen for early postoperative catheter removal and re-catheterization in patients undergoing elective laparoscopic colorectal cancer surgery within an optimal ERAS setting.

Methods: This was a single-center prospective study of patients undergoing elective minimally invasive colorectal resection and postoperative catheter removal within 24 h, with a re-catheterization threshold of 800 ml bladder volume. Read More

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http://dx.doi.org/10.1007/s00268-019-05010-1DOI Listing

Female lower urinary tract microbiota do not associate with IC/PBS symptoms: a case-controlled study.

Int Urogynecol J 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology and Immunology, Loyola University Chicago, Health Sciences Division, Stritch School of Medicine, Maywood, IL, 60153, USA.

Introduction And Hypothesis: The current etiology of interstitial cystitis/painful bladder syndrome (IC/PBS) is poorly understood and multifactorial. Recent studies suggest the female urinary microbiota (FUM) contribute to IC/PBS symptoms. This study was designed to determine if the FUM, analyzed using mid-stream voided urine samples, differs between IC/PBS patients and controls. Read More

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http://dx.doi.org/10.1007/s00192-019-03942-9DOI Listing

Precise definition of PTEN C-terminal epitopes and its implications in clinical oncology.

NPJ Precis Oncol 2019 15;3:11. Epub 2019 Apr 15.

Biocruces-Bizkaia Health Research Institute, Barakaldo, Spain.

Anti-PTEN monoclonal antibodies (mAb) are arising as important tools for immunohistochemistry (IHC) and protein quantification routine analysis in clinical oncology. Although an effort has been made to document the reliability of tumor tissue section immunostaining by anti-PTEN mAb, and to standardize their IHC use in research and in the clinical practice, the precise topological and biochemical definition of the epitope recognized by each mAb has been conventionally overlooked. In this study, six commercial anti-PTEN mAb have been validated and characterized for sensitivity and specificity by IHC and FISH, using a set of prostate and urothelial bladder tumor specimens, and by immunoblot, using PTEN positive and PTEN negative human cell lines. Read More

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http://dx.doi.org/10.1038/s41698-019-0083-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465295PMC

CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors.

Cell Death Discov 2019 11;5:87. Epub 2019 Apr 11.

3Cancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), PO Box 34110, Doha, Qatar.

The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tumor cells. In the current study, we observed that several cancer cell lines, e. Read More

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http://dx.doi.org/10.1038/s41420-019-0169-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459874PMC

Dual TGFβ/BMP pathway inhibition enables expansion and characterization of multiple epithelial cell types of the normal and cancerous breast.

Mol Cancer Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Indiana University School of Medicine

Functional modeling of normal breast epithelial hierarchy and stromal-epithelial cell interactions have been difficult due to inability to obtain sufficient stem-progenitor-mature epithelial and stromal cells. Recently reported epithelial reprogramming assay has partially overcome this limitation, but cross contamination of cells from the feeder layer is a concern. The purpose of this study was to develop a feeder-layer independent inexpensive method to propagate multiple cell types from limited tissue resources. Read More

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0165DOI Listing

Uro-Vaxom® versus placebo for the prevention of recurrent symptomatic urinary tract infections in participants with chronic neurogenic bladder dysfunction: a randomised controlled feasibility study.

Trials 2019 Apr 16;20(1):223. Epub 2019 Apr 16.

National Spinal Injuries Centre, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Aylesbury, HP21 8AL, UK.

Background: Patients with lower neurogenic bladder dysfunction are at an increased risk of suffering from recurrent urinary tract infections. Recurrent symptomatic urinary tract infection is occasionally treated with antibiotics as a prophylactic prevention strategy. This risks increasing the frequency of antibiotic resistance. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-019-3275-xDOI Listing
April 2019
1 Read

Systematic Multiomics Analysis of Alterations in C1QBP mRNA Expression and Relevance for Clinical Outcomes in Cancers.

J Clin Med 2019 Apr 15;8(4). Epub 2019 Apr 15.

Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.

C1QBP (Complement Component 1 Q Subcomponent-Binding Protein), a multicompartmental protein, participates in various cellular processes, including mRNA splicing, ribosome biogenesis, protein synthesis in mitochondria, apoptosis, transcriptional regulation, and infection processes of viruses. The correlation of C1QBP expression with patient survival and molecular function of C1QBP in relation to cancer progression has not been comprehensively studied. Therefore, we sought to systematically investigate the expression of C1QBP to evaluate the change of C1QBP expression and the relationship with patient survival and affected pathways in breast, lung, colon, and bladder cancers as well as lymphoma. Read More

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http://dx.doi.org/10.3390/jcm8040513DOI Listing

Availability and quality assessment of online nutrition information materials for pelvic cancer patients in the UK.

Eur J Cancer Care (Engl) 2019 Apr 16:e13039. Epub 2019 Apr 16.

School of Nursing and Midwifery, Oxford Brookes University, Oxford, UK.

Objective: Written information can be an essential source of support in the promotion of lifestyle changes after a cancer diagnosis. This study aimed to identify and assess the quality of available online patient information materials (PIMs) in relation to diet and nutrition for patients with pelvic cancer.

Methods: The online sources of the National Health Service, cancer centres and charitable organisations throughout the UK were searched. Read More

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http://dx.doi.org/10.1111/ecc.13039DOI Listing

[Mining and discovery for active components of "Coptidis Rhizome-Magnoliae Officinalis Cortex" based on network pharmacology].

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(4):803-810

College of Chinese Medicine,School of Traditional Chinese Pharmacy,China Pharmaceutical University Nanjing 211198,China.

To mine and discover the active components of " Coptidis Rhizome-Magnoliae Officinalis Cortex( C&M) " based on the network pharmacology,integrate and analyze the potential targets and mechanisms. The TCMSP database was used to screen active ingredients. TTD and Drug Bank databases were used to predict the potential targets by referring to relevant literature,and the pathway annotation technology was used to enrich and analyze the active ingredients and potential targets of " C&M". Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181129.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181129.001DOI Listing
February 2019
2 Reads

National trends in urinary diversion over the past 20 years: an Australian study.

ANZ J Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Urology, Westmead Hospital, Sydney, New South Wales, Australia.

Background: To investigate the trends in urinary diversion (UD) in Australia over the past 20 years, to correlate with patient demographics and to compare with international data.

Methods: A retrospective analysis of Medicare Australia data was performed using the relevant Medicare Benefit Schedule procedure codes over the past 20 years. Included diversion procedures were ureterocutaneous, ureterocolonic, intestinal conduit and continent reservoir. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ans.15134
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http://dx.doi.org/10.1111/ans.15134DOI Listing
April 2019
1 Read

Neuregulin-1-ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide-induced cystitis.

Neurourol Urodyn 2019 Apr 15. Epub 2019 Apr 15.

Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Aims: Central sensitization playsimportant roles in cyclophosphamide (CYP)-induced cystitis. In addition, as a visceral pain, CYP-induced chronic pain shares common pathophysiological mechanisms with neuropathic pain. Previous studies demonstrated that neuregulin-1 (Nrg1)-ErbB signaling contributes to neuropathic pain, but whether and how this signaling influences mechanical allodynia in CYP-induced cystitis is unclear. Read More

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http://dx.doi.org/10.1002/nau.24005DOI Listing

Investigation of the relationship between bladder function and sarcopenia using pressure flow studies in elderly male patients.

Neurourol Urodyn 2019 Apr 15. Epub 2019 Apr 15.

Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Aims: Although detrusor underactivity is often encountered in elderly patients, the etiology remains unclear. We have hypothesized that sarcopenia was associated with impaired bladder contractility. Therefore, we have evaluated the relationship between bladder contractility and clinical parameters including sarcopenia markers in elderly male patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/nau.24001
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http://dx.doi.org/10.1002/nau.24001DOI Listing
April 2019
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Comparing Outcomes of Medical Management and Minimally Invasive Surgical Techniques for Lower Urinary Tract Symptoms due to BPH.

Curr Urol Rep 2019 Apr 15;20(6):29. Epub 2019 Apr 15.

Division of Urology, Robert Wood Johnson Medical School, 125 Patterson St, MEB 584A, New Brunswick, NJ, 08901, USA.

Purpose Of Review: Compare outcomes of medical therapy as compared to minimally invasive surgical therapy (MIST) for treatment of bladder outlet obstruction RECENT FINDINGS: Treatment for lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH) remains largely driven by patient symptomatology with medical therapy or watchful waiting as the first-line management strategies. However, most patients are not adherent to prescribed medical therapies and are hesitant to accept the risks associated with more invasive therapies. Minimally invasive surgical therapies are treatments providing short-term symptom relief superior to medical therapies without the sequela of more invasive procedures. Read More

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http://dx.doi.org/10.1007/s11934-019-0896-2DOI Listing

A Bayesian approach for semiparametric regression analysis of panel count data.

Lifetime Data Anal 2019 Apr 15. Epub 2019 Apr 15.

Department of Statistics, University of South Carolina, Columbia, SC, 29208, USA.

Panel count data commonly arise in epidemiological, social science, and medical studies, in which subjects have repeated measurements on the recurrent events of interest at different observation times. Since the subjects are not under continuous monitoring, the exact times of those recurrent events are not observed but the counts of such events within the adjacent observation times are known. A Bayesian semiparametric approach is proposed for analyzing panel count data under the proportional mean model. Read More

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http://dx.doi.org/10.1007/s10985-019-09471-3DOI Listing

Oxygen Venous Embolism After Hydrogen Peroxide Use During Percutaneous Nephrolithotomy.

J Endourol Case Rep 2019 18;5(1):25-27. Epub 2019 Mar 18.

Department of Urology, George Washington University Medical School, Washington, District of Columbia.

Hydrogen peroxide (HO) is a common antiseptic that is available without a prescription in the United States, and it is indicated for minor dermal abrasion; mouth, gum, or dental irritations; and removal of oral secretion. Several other medical uses have also been described, including clot dissolution during endoscopic gastrointestinal evaluation, cleansing of orthopedic surgical sites, and bladder irrigation. However, these uses of HO, as well as high-dose ingestion, have been associated with a wide variety of medical complications, including but not limited to air pulmonary embolism and stroke. Read More

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https://www.liebertpub.com/doi/10.1089/cren.2018.0111
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http://dx.doi.org/10.1089/cren.2018.0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461058PMC
March 2019
1 Read

Cystoscopically Guided Repair of a Posterior Perforation of Augmented Bladder.

J Endourol Case Rep 2019 18;5(1):22-24. Epub 2019 Mar 18.

Department of Urology, San Antonio Military Medical Center, San Antonio, Texas.

Augmentation cystoplasty for the management of neurogenic bladder is one of the mainstays of pediatric urology. This procedure has multiple well-known complications. The most dangerous of these complications is bladder perforation, which has a mortality rate of 23% to 25% in large part caused by delayed presentation and sepsis. Read More

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https://www.liebertpub.com/doi/10.1089/cren.2018.0065
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http://dx.doi.org/10.1089/cren.2018.0065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461056PMC
March 2019
1 Read

Endourologic Treatment for Aggressive Angiomyxoma of the Bladder.

J Endourol Case Rep 2019 18;5(1):19-21. Epub 2019 Mar 18.

Faculdade São Leopoldo Mandic, Campinas, Brazil.

Aggressive angiomyxoma (AA) is a rare tumor that usually appears in the female pelvic and perineal regions. It commonly has infiltrative behavior and high local recurrence risk. We report an unusual presentation of AA, originating in a female patient's bladder. Read More

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http://dx.doi.org/10.1089/cren.2018.0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461054PMC

Stem Cells Seeded on Multilayered Scaffolds Implanted into an Injured Bladder Rat Model Improves Bladder Function.

Tissue Eng Regen Med 2019 Apr 22;16(2):201-212. Epub 2019 Mar 22.

1Department of Urology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591 Republic of Korea.

Background: To investigate whether human adipose-derived stem cells (hADSCs) seeded on multilayered poly (l-lactide--ɛ-caprolactone) (PLCL) sheets improve bladder function in a rat model of detrusor smooth muscle-removed bladder.

Methods: Male rats were randomly divided into 4 groups: Normal, injury (detrusor smooth muscle-removed bladder), PLCL (detrusor smooth muscle-removed bladder implanted with PLCL sheets), and PLCL + ADSC (detrusor smooth muscle-removed bladder implanted with PLCL sheets seeded with hADSCs). Four weeks after the treatment, physiological, histological, immunohistochemical, and immunoblot analyses were performed. Read More

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http://dx.doi.org/10.1007/s13770-019-00187-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439074PMC

Expression of miR-490-5p, miR-148a-3p and miR-608 in bladder cancer and their effects on the biological characteristics of bladder cancer cells.

Oncol Lett 2019 May 12;17(5):4437-4442. Epub 2019 Mar 12.

Department of Emergency, Hunan Provincial People's Hospital, Changsha, Hunan 410005, P.R. China.

Changes in the expression of miR-490-5p, miR-148a-3p and miR-608 in bladder cancer tissues were studied. A total of 30 patients with bladder cancer who had surgical resection in the Hunan Provincial People's Hospital (Changsha, China) from April 2015 to August 2016 were selected. RT-qPCR was used to detect the expression levels of miR-490-5p, miR-148a-3p and miR-608. Read More

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http://dx.doi.org/10.3892/ol.2019.10143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447928PMC

miR-758-3p suppresses human bladder cancer cell proliferation, migration and invasion by targeting NOTCH2.

Exp Ther Med 2019 May 18;17(5):4273-4278. Epub 2019 Mar 18.

Department of Urology Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei College of Arts and Sciences, Xiangyang, Hubei 441021, P.R. China.

MicroRNAs (miRs) are widely involved in regulating tumor development and progression. miR-758-3p has been reported to suppress the progression of various cancer types, including hepatocellular carcinoma. However, whether miR-758-3p has a role in bladder cancer (BC) has not been previously reported, and was thus investigated in the present study. Read More

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http://dx.doi.org/10.3892/etm.2019.7400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447895PMC

Honokiol induces apoptotic cell death by oxidative burst and mitochondrial hyperpolarization of bladder cancer cells.

Exp Ther Med 2019 May 20;17(5):4213-4222. Epub 2019 Mar 20.

Center for Cell Therapy, Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan R.O.C.

Bladder cancer is one of the most common types of malignant tumor worldwide. Current treatments, including chemo-/radiotherapy, only have limited efficacy on bladder cancer progression. Honokiol is an active component of with multiple biological effects that may provide promising health benefits. Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7419
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http://dx.doi.org/10.3892/etm.2019.7419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447899PMC
May 2019
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Noninvasive Detection of Bladder Cancer by Shallow-Depth Genome-Wide Bisulfite Sequencing of Urinary Cell-Free DNA for Methylation and Copy Number Profiling.

Clin Chem 2019 Apr 15. Epub 2019 Apr 15.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong

Background: The current diagnosis and monitoring of bladder cancer are heavily reliant on cystoscopy, an invasive and costly procedure. Previous efforts in urine-based detection of bladder cancer focused on targeted approaches that are predicated on the tumor expressing specific aberrations. We aimed to noninvasively detect bladder cancer by the genome-wide assessment of methylomic and copy number aberrations (CNAs). Read More

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http://dx.doi.org/10.1373/clinchem.2018.301341DOI Listing

Detection of NRG1 gene fusions in solid tumors.

Clin Cancer Res 2019 Apr 15. Epub 2019 Apr 15.

Medical Oncology, Georgetown University

Background: NRG1 gene fusions are rare but potentially actionable oncogenic drivers present in some solid tumors. Details regarding the incidence of these gene rearrangements are lacking. Here, we assessed the incidence of NRG1 fusions across multiple tumor types and described fusion partners. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0160DOI Listing

The tumor immune microenvironment drives a prognostic relevance that correlates with bladder cancer subtypes.

Cancer Immunol Res 2019 Apr 15. Epub 2019 Apr 15.

Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg

Muscle-invasive bladder cancer (MIBC) represents approximately two-thirds of invasive urothelial bladder cancers (UBCs) and has high morbidity and mortality. Men are over 3-fold more frequently affected by UBC than women. Despite intensive efforts to improve patient treatment and outcome, two-thirds of patients with UBC will have a recurrence or disease progression within 5 years. Read More

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0758DOI Listing

Re: Impact of Adjuvant Chemotherapy in Patients with Adverse Features and Variant Histology at Radical Cystectomy for Muscle-invasive Carcinoma of the Bladder: Does Histologic Subtype Matter?

Eur Urol 2019 Apr 12. Epub 2019 Apr 12.

Department of Urology, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838193027
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http://dx.doi.org/10.1016/j.eururo.2019.03.040DOI Listing
April 2019
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Re: Extended Versus Limited Lymph Node Dissection in Bladder Cancer Patients Undergoing Radical Cystectomy: Survival Results from a Prospective, Randomized Trial.

Eur Urol 2019 Apr 12. Epub 2019 Apr 12.

Division of Urology, Department of Surgical Sciences, San Giovanni Battista Hospital, University of Studies of Torino, Turin, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2019.03.042DOI Listing

Targeting amine- and phenol-containing metabolites in urine by dansylation isotope labeling and liquid chromatography mass spectrometry for evaluation of bladder cancer biomarkers.

J Food Drug Anal 2019 Apr 7;27(2):460-474. Epub 2019 Jan 7.

Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Liver Research Center, Chang Gung Memorial Hospital at Linkou, Gueishan, Taoyuan, 33305, Taiwan; Department of Cell and Molecular Biology, Chang Gung University, Guishan, Taoyuan, 33302, Taiwan; Research Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.

Metabolomics is considered an effective approach for understanding metabolic responses in complex biological systems. Accordingly, it has attracted increasing attention for biomarker discovery, especially in cancer. In this study, we used a non-invasive method to evaluate four urine metabolite biomarker candidates-o-phosphoethanolamine, 3-amio-2-piperidone, uridine and 5-hydroxyindoleactic acid-for their potential as bladder cancer diagnostic biomarkers. Read More

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http://dx.doi.org/10.1016/j.jfda.2018.11.008DOI Listing

Development of biomarkers of genitourinary cancer using mass spectrometry-based clinical proteomics.

J Food Drug Anal 2019 Apr 27;27(2):387-403. Epub 2018 Oct 27.

Division of Urology, Department of Surgery, LinKou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Prostate, bladder and kidney cancer are the three most common types of genitourinary cancer in the world. Of these, prostate and bladder cancers are within the top 10 most common cancers in men. Notably, kidney cancer causes no obvious symptoms in the early stages. Read More

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http://dx.doi.org/10.1016/j.jfda.2018.09.005DOI Listing