18,489 results match your criteria Bladder Management


Structure and function of proprotein convertase subtilisin/kexin type 9 (PCSK9) in atherosclerosis.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214141626DOI Listing
February 2019

Recent advances in rational diagnosis and treatment of normal pressure hydrocephalus: A critical appraisal on novel diagnostic, therapy monitoring and treatment modalities.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214121342DOI Listing
February 2019

Surfer's myelopathy: A review of etiology, pathogenesis, evaluation, and management.

J Spinal Cord Med 2019 Feb 15:1-6. Epub 2019 Feb 15.

a Department of Physiology and Biophysics , Stony Brook University School of Medicine , Stony Brook , New York , USA.

Context: Surfer's myelopathy (SM) is an acute syndrome identified by nontraumatic paraparesis or paraplegia. Though traditionally tied to first-time surfers, the condition encompasses any activity involving hyperextension of the back such as gymnastics, yoga, and Pilates.

Methods: MEDLINE and Google Scholar literature searches were gathered to identify relevant case reports for determining the etiology, pathogenesis, evaluation, and management of SM. Read More

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http://dx.doi.org/10.1080/10790268.2019.1577057DOI Listing
February 2019

Genital Infections with Sodium Glucose Cotransporter-2 Inhibitors: Occurrence and Management in Patients with Type 2 Diabetes Mellitus.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):837-842

Medical Affairs, AstraZeneca Pharma India Ltd., Bengaluru, Karnataka, India.

Diabetes is a metabolic disorder characterized by hyperglycemia and is associated with several comorbidities and complications. Genital infection is one such complication that is often associated with diabetes mellitus (DM). Even though abnormalities in immune system, high urine glucose, and bladder dysfunction are important contributors for the increased risk of genitourinary symptoms, yet the possible role of pharmacologically induced glucosuria cannot be completely overlooked in such patients. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_159_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330876PMC
February 2019

Quality of Life in Patients With Low-Risk Prostate Cancer Treated With Hypofractionated vs Conventional Radiotherapy: A Phase 3 Randomized Clinical Trial.

JAMA Oncol 2019 Feb 14. Epub 2019 Feb 14.

Henry Ford Hospital, Detroit, Michigan.

Importance: Hypofractionated radiotherapy (HRT) would be more convenient for men with low-risk prostate cancer and cost less than conventional radiotherapy (CRT) as long as HRT is noninferior to CRT in terms of survival and quality of life (QOL) is not found to be worse.

Objective: To assess differences in QOL between men with low-risk prostate cancer who are treated with HRT vs CRT.

Design, Setting, And Participants: In this phase 3 randomized clinical trial, men with low-risk prostate cancer were enrolled from sites within the National Cancer Institute's National Clinical Trials Network in the United States, Canada, and Switzerland. Read More

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http://dx.doi.org/10.1001/jamaoncol.2018.6752DOI Listing
February 2019

Upper urinary tract recurrence following bladder cancer therapy: a review of surveillance and management.

Curr Opin Urol 2019 Feb 11. Epub 2019 Feb 11.

USC Institute of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.

Purpose Of Review: Our aim is to review recent investigations into the recurrence of urothelial carcinoma in the upper urinary tract following bladder cancer therapy focusing on surveillance and management.

Recent Findings: After radical cystectomy, rates of recurrence in the upper tract are between 0.75 and 6. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000598DOI Listing
February 2019

Salvage therapeutic strategies for bacillus Calmette-Guerin failure.

Curr Opin Urol 2019 Feb 11. Epub 2019 Feb 11.

Department of Urology and Comprehensive Cancer Center, Vienna General Hospital, Medical University of Vienna.

Purpose Of Review: To give an overview of current options for conservative treatment of patients failing intravesical bacillus Calmette-Guerin (BCG) and to discuss emerging approaches with potential future clinical applications.

Recent Findings: Radical cystectomy is the standard-of-care for patients failing BCG therapy. In patients unfit or unwilling to undergo surgery, salvage therapy options could be proposed with the aim to offer local cancer control and prevent progression to muscle-invasive disease. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000593DOI Listing
February 2019
4 Reads

New trends in voiding cystourethrography and vesicoureteral reflux: Who, when and how?

Int J Urol 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Vesicoureteral reflux, retrograde flow of urine from the bladder into the upper urinary tract, is one of the most common urological diagnoses in the pediatric population. Diagnosis and subsequent management of urinary reflux have become increasingly debated in the past decade, with divergent opinions over which patients should be evaluated for reflux, and when detected, which children should receive intervention. Although some argue that vesicoureteral reflux is a "phenotype" that often resolves without intervention, others contest that untreated reflux has the potential to cause irreversible renal damage over time. Read More

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http://doi.wiley.com/10.1111/iju.13915
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http://dx.doi.org/10.1111/iju.13915DOI Listing
February 2019
1 Read

[Interstitial laser coagulation in the management of urothelial papillary carcinoma of the renal pelvis].

Urologiia 2018 Oct(4):122-126

Research Clinical Center of JSC RZD, Moscow, Russia.

This article presents a case of a 59-year-old patient with a primary tumor of the right kidney with bladder and liver metastases. The patient was treated in three-stages. In the first stage, he underwent ureteral stone extraction, laser resection of the tumor with subsequent vaporization. Read More

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October 2018

[An interdisciplinary approach to the management of bladder endometriosis].

Urologiia 2018 Oct(4):118-121

Ya.L. Tsivyan Novosibirsk Scientific Research Institute of Traumatology and Orthopedics of Minzdrav of Russia, Novosibirsk, Russia.

Urinary endometriosis a rare condition accounting for 1-5.5% of all of the extragenital endometriosis locations. Bladder endometriosis is the most common form of urinary endometriosis, comprising 85% of cases. Read More

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October 2018

[The effectiveness of complex phytotherapeutic medications in the management of uncomplicated lower urinary tract infections in women].

Urologiia 2018 Oct(4):10-13

Department of Urology, N.N. Burdenko Voronezh State Medical University, Voronezh, Russia.

Introduction: Lower urinary tract infections (LUTI) are the most common urological diseases. Fosfomycin is one of the antibiotic agents with proven efficacy that are most frequently used to treat UTIs. Despite the high effectiveness of antibiotic therapy with this drug, in some patients, the LUTIs persist or recur. Read More

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October 2018

Acute Acalculous Cholecystitis as a Presenting Manifestation in Systemic Lupus Erythematosus.

Eur J Case Rep Intern Med 2016 11;3(4):000408. Epub 2016 May 11.

Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School/Saint Peter's University Hospital, New Brunswick, New Jersey, USA.

Systemic lupus erythematosus (SLE) is known to involve the gastrointestinal tract, but gallbladder involvement is rare. The authors report the case of a 26-year-old postpartum female who presented with acute right upper quadrant abdominal pain and was diagnosed with acute acalculous cholecystitis (AAC). In the presence of concomitant features of nephritis, pericardial effusion, anaemia and positive ANA titre, the diagnosis of SLE was confirmed during hospitalisation. Read More

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http://dx.doi.org/10.12890/2016_000408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346864PMC

Laparoscopic management of a large urethral leiomyoma.

Int Urogynecol J 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.

Introduction And Hypothesis: A 42-year-old female presented with a 12-cm mass bulging the anterior vaginal wall and causing urgency urinary incontinence and bulk symptoms.

Methods: Imaging showed a tumor originating from the dorsal and cranial part of the urethra and developing in the vesicouterine space and vesicovaginal septum, dislocating the bladder ventrally and the uterus cranial-dorsally.

Results: Tranvaginal biopsy showed a benign leiomyoma. Read More

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http://dx.doi.org/10.1007/s00192-019-03889-xDOI Listing
February 2019

Metabolic and Molecular Basis of Sarcopenia: Implications in the Management of Urothelial Carcinoma.

Int J Mol Sci 2019 Feb 11;20(3). Epub 2019 Feb 11.

Department of Urology, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan.

Sarcopenia, which represents the degenerative and systemic loss of skeletal muscle mass, is a multifactorial syndrome caused by various clinical conditions. Sarcopenia reflects not only frailty and poor general health status, but also the possible presence of advanced or progressive cancer or cancer cachexia. Therefore, sarcopenia affects the management of cancer-bearing patients, including those with urothelial carcinoma. Read More

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http://dx.doi.org/10.3390/ijms20030760DOI Listing
February 2019

[Russian version of the neurogenic bladder symptom score (NBSS)].

Urologiia 2018 Dec(6):5-13

Ural State Medical University, Sverdlovsk Regional Clinical Hospital 1, Ekaterinburg, Russia.

Aim: The Neurogenic Bladder Symptom Score (NBSS) is widely used now for the bladder symptoms assessment in neurogenic low urinary tract dysfunction. It is suitable for all patients, regardless of a bladder management method. NBSS contains 24 questions, which focus on incontinence, storage and voiding symptoms, urinary complicationsand life quality. Read More

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December 2018
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[Retroperitoneal hemangiopericytoma-a rare case with multiple relapses-even 20 years after primary diagnosis].

Urologe A 2019 Feb 11. Epub 2019 Feb 11.

Klinik für Urologie und Kinderurologie, Universitätsklinikum Marburg, Philipps Universität Marburg, Baldingerstraße, 35039, Marburg, Deutschland.

A 41-year-old man without previous illness presented at our clinic with progressive pain in the lower abdomen and intermittent pain in the left flank. We found a lesion of unknown dignity which had anatomical contact to the bladder and rectum. Histological examination confirmed the diagnosis of hemangiopericytoma. Read More

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http://dx.doi.org/10.1007/s00120-019-0879-4DOI Listing
February 2019

[Analisys of non-neurogenic lower urinary tract dysfunction patterns controlled in a Pediatric urodynamic unit.]

Arch Esp Urol 2019 Jan;72(1):45-53

Hospital Materno Infantil Teresa Herrera. A Coruña. España.

Objectives: Between 7-10% of schoolagechildren are seen by specialists for non-neurogeniclower urinary tract dysfunction (LUTD). The objective ofour study is to classify these functional alterations in difused for the diagnosis and treatment in each pattern.

Material And Methods: We reviewed patients referredto our Urodynamic Unit for suspected LUTD for3 years; We reviewed epidemiological data, supplementarytest and treatments. Read More

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January 2019
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Management of blunt intraperitoneal bladder rupture: Case report and literature review.

Int J Surg Case Rep 2019 Feb 1;55:160-163. Epub 2019 Feb 1.

Department of Surgery, Kendall Regional Medical Center, Miami, FL, United States; University of South Florida, Tampa, FL, United States.

Introduction: Urinary bladder ruptures are an uncommon injury, occurring in less than 1% of all blunt abdominal trauma. Extraperitoneal bladder ruptures are generally associated with pelvic fractures and usually managed nonoperatively. Conversely, intraperitoneal injuries are often caused by large compressive and shear forces produced during seatbelt injuries and almost invariably require surgical intervention. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.038DOI Listing
February 2019

A Rare Case of Advanced Urethral Diverticular Adenocarcinoma and a Review of Treatment Modalities.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619828408

1 Brookdale University Hospitals and Medical Center, New York, NY, USA.

Female urethral diverticular cancer is a very rare entity with only around 100 cases reported so far in literature and accounts for <1% of all malignancies. In this article, we present a 47-year-old African American female with repeated hospital visits for urinary retention, hematuria, and urinary tract infections. Initial computed tomography imaging and cystoscopy was unremarkable except for a distended urinary bladder. Read More

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http://dx.doi.org/10.1177/2324709619828408DOI Listing
February 2019
1 Read

Chronic Lower Urinary Tract Signs in Cats: Current Understanding of Pathophysiology and Management.

Vet Clin North Am Small Anim Pract 2019 Mar;49(2):187-209

Department of Veterinary Medicine and Epidemiology University of California Davis, Davis, CA 95694, USA.

Cats that present with chronic lower urinary tract signs are often diagnosed with feline idiopathic/interstitial cystitis, a disease syndrome that is more than just a bladder disease and can be associated wtih a myriad of other co-morbidities. Further, gaining a better understanding of FIC (including the most accurate descriptive terminology) may help researchers, veterinarians, pet food companies, and clients develop and tailor the best possible approaches to management of these cat's unique health and welfare needs. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.11.001DOI Listing
March 2019
1 Read

Intra-bladder wall transplantation of bone marrow mesenchymal stem cells improved urinary bladder dysfunction following spinal cord injury.

Life Sci 2019 Feb 5. Epub 2019 Feb 5.

Faculty of Biomedical Engineering, Sahand University of Technology, Dept. of Biomechanics, Sahand, Iran.

Background: In the most of previous experiments, intrathecal administration of stem cells (SCs) was seen in the management of neurogenic bladder (NGB) following contusion or complete transaction in the rodent model of spinal cord injury (SCI). Here, we aimed to investigate whether intra bladder wall autologous bone marrow mesenchymal SC (BM-MSCs) transplantation, as a minimally invasive method, could improve bladder dysfunctions after a chronic phase of hemi- and complete-transection SCI in a female rat model.

Material And Methods: A total of forty-two female Wistar rats were randomly divided into 6 groups (each in 7) and subjected to complete and incomplete spinal cord transection by a laminectomy at the T9 vertebral level. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.011DOI Listing
February 2019
1 Read

Baseline Urinary Imaging in Infants Enrolled in Urologic Management to Preserve Initial Renal Function (UMPIRE) Protocol for Children with Spina Bifida.

J Urol 2019 Feb 5. Epub 2019 Feb 5.

Division of Nephrology, Boston Children's Hospital, Boston, MA.

Purpose: The lifetime risk of renal damage among children with spina bifida (SB) is high, but only limited baseline imaging data are available for this population. We therefore queried a large, prospective cohort of infants with SB to define their baseline imaging characteristics.

Patients And Methods: The Urologic Management to Preserve Initial Renal Function Protocol for Young Children with Spina Bifida (UMPIRE) is an iterative quality-improvement protocol that follows a cohort of newborns at nine US centers. Read More

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http://dx.doi.org/10.1097/JU.0000000000000141DOI Listing
February 2019
1 Read

Contemporary best practice in the use of neoadjuvant chemotherapy in muscle-invasive bladder cancer.

Ther Adv Urol 2019 Jan-Dec;11:1756287218823678. Epub 2019 Jan 28.

Department of Urology, Paris Descartes University, Paris, France.

Background: We aimed to provide a comprehensive literature review on the best practice management of patients with nonmetastatic muscle-invasive bladder cancer (MIBC) using neoadjuvant chemotherapy (NAC).

Method: Between July and September 2018, we conducted a systematic review using MEDLINE and EMBASE electronic bibliographic databases. The search strategy included the following terms: Neoadjuvant Therapy and Urinary Bladder Neoplasms. Read More

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http://dx.doi.org/10.1177/1756287218823678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350113PMC
January 2019
1 Read

Venous access-site closure with vascular closure device vs. manual compression in patients undergoing catheter ablation or left atrial appendage occlusion under uninterrupted anticoagulation: a multicentre experience on efficacy and complications.

Europace 2019 Feb 4. Epub 2019 Feb 4.

Texas Cardiac Arrhythmia Institute, St. David's Medical Center, 3000 N. I-35, Suite 720, Austin, TX, USA.

Aims: Manual compression (MC), widely used to achieve venous access haemostasis, needs prolonged immobilization and extended time-to-haemostasis. Vascular closure devices (VCD) have been reported to have significantly shorter time to haemostasis and ambulation in arterial access-site management. The current study aimed to evaluate the safety and efficacy as well as rate of urinary tract complications in patients receiving MC vs. Read More

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http://dx.doi.org/10.1093/europace/euz004DOI Listing
February 2019
2 Reads

Antimuscarinic drug therapy for overactive bladder syndrome in the elderly - are the concerns justified?

Authors:
Jay Khastgir

Expert Opin Pharmacother 2019 Feb 6:1-8. Epub 2019 Feb 6.

a Swansea University Medical School , Abertawe Bro Morganwwg University Health Board , Swansea , Wales , UK.

Introduction: The use of antimuscarinic drugs is common in the management of the overactive bladder (OAB). Concerns have been raised over their use in the elderly population in whom the use of these drugs is highly prevalent, consequent to the reported link between these drugs and cognitive impairment and dementia. Areas covered: Recent publications have heightened concerns regarding antimuscarinic drug use in the elderly. Read More

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http://dx.doi.org/10.1080/14656566.2019.1574749DOI Listing
February 2019
1 Read

Dietary restriction of iron availability attenuates UPEC pathogenesis in a mouse model of urinary tract infection.

Am J Physiol Renal Physiol 2019 Feb 6. Epub 2019 Feb 6.

Obstetrics and Gynecology, Washington University School of Medicine, United States.

Iron is a critical nutrient required by hosts and pathogens. Uropathogenic Escherichia coli (UPEC), the principal causative agent of urinary tract infections (UTIs), chelate iron for their survival and persistence. Here, we demonstrate that dietary modulation of iron availability limits UPEC burden in a mouse model of UTI. Read More

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http://dx.doi.org/10.1152/ajprenal.00133.2018DOI Listing
February 2019
2 Reads

Advances in surgical strategies for prolapse.

Climacteric 2019 Feb;22(1):60-64

a Division of Obstetrics and Gynecology, Department of Experimental and Clinical Medicine , University of Pisa , Pisa , Italy.

Pelvic floor dysfunctions are a complex condition in elderly women; pelvic organ prolapse, urinary or fecal incontinence, constipation, pelvic pain, and sexual dysfunction are common problems. The goal of surgical treatment is functional reconstruction with symptom management and repair of anatomic defects. The recent advancements in surgical treatment of pelvic floor dysfunction allow several good options for choosing the best surgery for each patient. Read More

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http://dx.doi.org/10.1080/13697137.2018.1543266DOI Listing
February 2019
2 Reads

Management of Advanced Bladder Cancer: An Update.

J Adv Pract Oncol 2018 May-Jun;9(4):410-416. Epub 2018 May 1.

Department of Genitourinary Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Bladder cancer is the sixth most common cancer in the United States; therefore, the majority of clinicians working in the oncology setting will care for this patient population. Unfortunately, treatment plans, especially in the advanced setting, lack consistency. This, along with the advanced age and comorbidities of most bladder cancer patients, can provide challenges for clinicians when developing treatment plans. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347090PMC

Intravesicular Onabotulinumtoxin A Hemorrhage on Rivaroxaban.

Case Rep Obstet Gynecol 2019 2;2019:5947153. Epub 2019 Jan 2.

Department of Urogynecology in Obstetrics & Gynecology, Walter Reed National Military Medical Center, Bethesda, MD, USA.

Overactive bladder (OAB) is urgency, with or without urgency incontinence. For OAB, an injection of onabotulinumtoxin A (BOTOX®) can be a low-risk outpatient procedure. We present a patient on a novel anticoagulant that experienced excessive bleeding after this procedure. Read More

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http://dx.doi.org/10.1155/2019/5947153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334352PMC
January 2019
1 Read

National Trends of Bladder Cancer and Trihalomethanes in Drinking Water: A Review and Multicountry Ecological Study.

Dose Response 2019 Jan-Mar;17(1):1559325818807781. Epub 2019 Jan 23.

Public Health Institute, Oakland, CA, USA.

We examined trends in incidence of bladder cancer in 8 countries in the 45+ years since trihalomethanes (THMs) were detected in chlorinated drinking water. Total trihalomethanes (TTHMs) are the principal regulated disinfection by-products (DBPs) along with halogenated acetic acids (HAAs). Numerous epidemiological studies have examined exposure to TTHMs and associations with bladder cancer. Read More

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http://dx.doi.org/10.1177/1559325818807781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348529PMC
January 2019
2 Reads

New technique for the management of anteriorly located midline prostatic cysts causing severe lower urinary tract symptoms: Case report and literature review.

Int J Surg Case Rep 2019 Jan 29;55:107-111. Epub 2019 Jan 29.

Division of Urology, Department of Surgery of Medicine and King Saud University Medical City, King Saud University, Saudi Arabia. Electronic address:

Introduction: Prostatic cysts are uncommon and usually asymptomatic. In most cases, these cysts are found incidentally by imaging. In some cases, these cysts can be symptomatic and missed for years. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.019DOI Listing
January 2019
1 Read

Complications and reoperations after laparoscopic radical cystectomy in a Japanese multicenter cohort.

Int J Urol 2019 Feb 1. Epub 2019 Feb 1.

Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Objectives: To describe the complications and their surgical management after laparoscopic radical cystectomy in a Japanese multicenter cohort.

Methods: The participants were drawn from a retrospective multicenter study at 10 institutions. We identified 436 patients who underwent laparoscopic radical cystectomy with no robot assistance. Read More

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http://dx.doi.org/10.1111/iju.13917DOI Listing
February 2019
2 Reads

The evolving role of protein disulfide isomerase A3 in Egyptian bladder cancer patients.

Gene 2019 Jan 29;693:76-83. Epub 2019 Jan 29.

Department of Anatomy, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt.

Background: Protein disulfide isomerase A3 (PDIA3), an endoplasmic reticulum protein, is expressed in bladder of BC patients. However, its role in BC has been elusive till now.

Objectives: This study was conducted to assess whether PDIA3 gene expression was associated with increased odds of BC, in particular muscle-invasive BC (MIBC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193006
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http://dx.doi.org/10.1016/j.gene.2019.01.024DOI Listing
January 2019
2 Reads

Squamous cell carcinoma of the bladder: poor response to neoadjuvant chemotherapy.

Int J Clin Oncol 2019 Feb 1. Epub 2019 Feb 1.

Division of Urology, Department of Surgery, Saint Louis University, 3635 Vista Ave, 3rd Floor Desloge Towers, St. Louis, MO, 63110, USA.

Background: Squamous cell carcinoma (SCC) of the bladder is a rare, aggressive malignancy. Unlike urothelial cell carcinoma, SCC is resistant to chemotherapy and guidelines recommend radical cystectomy (RC) without neoadjuvant chemotherapy (NAC). We aimed to evaluate the current management and survival of patients with invasive SCC treated with or without NAC. Read More

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http://dx.doi.org/10.1007/s10147-019-01409-xDOI Listing
February 2019
1 Read

Interventions for treating urinary incontinence after stroke in adults.

Cochrane Database Syst Rev 2019 Feb 1;2:CD004462. Epub 2019 Feb 1.

Faculty of Health and Wellbeing, University of Central Lancashire, Room 416, Brook Building, Preston, Lancashire, UK, PR1 2HE.

Background: Urinary incontinence can affect 40% to 60% of people admitted to hospital after a stroke, with 25% still having problems when discharged from hospital and 15% remaining incontinent after one year.This is an update of a review published in 2005 and updated in 2008.

Objectives: To assess the effects of interventions for treating urinary incontinence after stroke in adults at least one-month post-stroke. Read More

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http://doi.wiley.com/10.1002/14651858.CD004462.pub4
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http://dx.doi.org/10.1002/14651858.CD004462.pub4DOI Listing
February 2019
3 Reads

Role of Adjuvant Chemotherapy in Resected T2N0 Gall Bladder Cancer.

J Gastrointest Surg 2019 Jan 31. Epub 2019 Jan 31.

Gastrointestinal Oncology services, Department of Medical Oncology, Tata Memorial Hospital, Dr. E. Borges Marg, Parel, Mumbai, 400012, India.

Background: Management of operable gall bladder cancer (GBC) is closely related to its tumor (T) and nodal (N) status. The magnitude of benefit with adjuvant chemotherapy in completely resected, node negative T2 cancers is not completely defined.

Materials And Methods: Retrospective analysis of patients diagnosed with pathological T2N0 (stage II, 7th edition AJCC) GBCs from January 2011 to June 2016 was evaluated for adverse risk factors, adjuvant treatment received, recurrence-free survival (RFS), and overall survival (OS). Read More

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http://dx.doi.org/10.1007/s11605-019-04104-4DOI Listing
January 2019
2.798 Impact Factor

Limited energy parametrial resection/dissection during modified laparoscopic nerve-sparing radical hysterectomy.

Chin J Cancer Res 2018 Dec;30(6):647-655

Department of Gynecology Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: The aim of this study was to investigate the feasibility of using ultrasonic scalpel combined with vascular clip in parametrial management, called limited energy parametrial resection/dissection (LEPRD), in laparoscopic nerve plane-sparing radical hysterectomy (NPSRH), a modified nerve-sparing radical hysterectomy (NSRH); and to evaluate its effectiveness in pelvic autonomic nerve preservation.

Methods: From July 2012 to January 2016, 257 consecutive patients with stage IB1 to IIA2 cervical cancer who underwent NPSRH were included in this study. Patients were divided into three cohorts according to the different parametrial resection modality. Read More

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http://dx.doi.org/10.21147/j.issn.1000-9604.2018.06.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328507PMC
December 2018
1 Read

A biologic scaffold-associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy.

Sci Transl Med 2019 Jan;11(477)

Translational Tissue Engineering Center, Baltimore, MD 21231, USA.

Biomaterials in regenerative medicine are designed to mimic and modulate tissue environments to promote repair. Biologic scaffolds (derived from decellularized tissue extracellular matrix) promote a wound-healing (proregenerative) immune phenotype and are used clinically to treat tissue loss, including in the context of tumor resection. It is unknown whether a biomaterial microenvironment that encourages tissue formation may also promote tumor development. Read More

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http://dx.doi.org/10.1126/scitranslmed.aat7973DOI Listing
January 2019
15.843 Impact Factor

MicroRNA dysregulation and non-muscle invasive bladder cancer prognosis.

Cancer Epidemiol Biomarkers Prev 2019 Jan 30. Epub 2019 Jan 30.

Dartmouth-Hitchcock Medical Center.

Background: The high rate of non-muscle invasive bladder cancer recurrence is a major challenge in patient management. microRNAs (miRNAs) functionally regulate tumor cell proliferation and invasion, and have strong potential as biomarkers, since they are robust to degradation. The objective of this project was to identify reproducible prognostic miRNAs in resected non-muscle invasive bladder tumor tissue that are predictive of the recurrent tumor phenotype. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0884DOI Listing
January 2019

Systematic review on near miss cases of placenta accreta spectrum disorders: correlation with invasion topography, prenatal imaging, and surgical outcome.

J Matern Fetal Neonatal Med 2019 Jan 30:1-8. Epub 2019 Jan 30.

b School of Medicine , University of Buenos Aires , Buenos Aires , Argentina.

Purpose of the article: Placental accreta spectrum (PAS) is the most dangerous iatrogenic complication of cesarean potentially leading to massive intra-partum haemorrhage and death. Despite this, identification of near miss cases of PAS has not been consistently reported in the published literature. The aim of this systematic review was to explore prenatal and surgical characteristics of near miss cases of PAS disorders. Read More

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http://dx.doi.org/10.1080/14767058.2019.1570494DOI Listing
January 2019

Identifying the most reliable and valid bladder health screening tool: a systematic review.

Disabil Rehabil 2019 Jan 29:1-20. Epub 2019 Jan 29.

a School of Health and Life Sciences , Glasgow Caledonian University , Glasgow , UK.

Purpose: Lower urinary tract symptoms are common in advancing age and a major cause of disability through avoidance of activity and social engagement. This systematic review aimed to identify the most valid and reliable brief screening tool for these symptoms or bladder problems, to incorporate into a health promotion programme for older adults to facilitate discussion about self-management.

Method: Review eligibility criteria included studies published between 1990 and November 2018, reporting the validity, reliability and/or acceptability of bladder health screening tools. Read More

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https://www.tandfonline.com/doi/full/10.1080/09638288.2018.1
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http://dx.doi.org/10.1080/09638288.2018.1561953DOI Listing
January 2019
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[Comparison of perioperative conditions between total and partial colpocleisis for elderly patients suffered from severe pelvic organ prolapse].

Zhonghua Fu Chan Ke Za Zhi 2019 Jan;54(1):33-37

Departmemt of Gynecology, Peking University People's Hospital, Beijing 100044, China.

To study perioperative period conditions of total and partial colpocleisis with severe pelvic organ prolapse (POP) in elderly patients. From Jan. 2014 to Oct. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.01.008DOI Listing
January 2019
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Iron Chelation as Novel Treatment for Interstitial Cystitis.

Pharmacology 2019 Jan 29;103(3-4):159-162. Epub 2019 Jan 29.

Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia,

Interstitial cystitis (IC) is a highly prevalent debilitating disease, with its cardinal symptoms being severe pain, urinary urgency and frequency. The associated pain may eventually lead as a last resort to removal of the bladder. Though the initial trigger for IC remains largely unknown, we propose novel iron chelators as a possible new treatment for this disease. Read More

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http://dx.doi.org/10.1159/000496089DOI Listing
January 2019

The Feasibility of a Healthcare Application in the Management of Patients Undergoing a Radical Cystectomy.

J Urol 2019 Jan 25. Epub 2019 Jan 25.

University of Kansas Health System, Department of Urology.

Purpose: Patients who undergo radical cystectomy for bladder cancer are at high risk of complications and readmissions. Studies indicate insufficient preoperative education and perioperative monitoring. The aim of this study is to demonstrate the feasibility of implementing a health care application to provide more patient education and more thorough monitoring perioperatively. Read More

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http://dx.doi.org/10.1097/JU.0000000000000050DOI Listing
January 2019
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The Challenge of Managing Bladder Cancer and Upper Tract Urothelial Carcinoma: A Review with Treatment Recommendations from the Spanish Oncology Genitourinary Group (SOGUG).

Target Oncol 2019 Jan 29. Epub 2019 Jan 29.

Medical Oncology Service, Hospital General Universitario Gregorio Marañon, Madrid, Spain.

Bladder cancer is the fourth most common cancer in men and the ninth most common in women in the Western world. The management of bladder carcinoma requires a multidisciplinary approach. Optimal treatment depends on several factors, including histology, stage, patient status, and possible comorbidities. Read More

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http://dx.doi.org/10.1007/s11523-019-00619-7DOI Listing
January 2019

Female underactive bladder - Current status and management.

Indian J Urol 2019 Jan-Mar;35(1):18-24

Department of Urology, Massachusetts General Hospital, Boston, USA.

Underactive bladder (UAB) is defined by the International Continence Society as a symptom complex characterized by a slow urinary stream, hesitancy, and straining to void, with or without a feeling of incomplete bladder emptying sometimes with storage symptoms. Until recently, the topic has received little attention in the literature probably due to a lack of consistent definitions and diagnostic criteria. We performed a literature review to identify articles related to the diagnosis and management of UAB, specifically in female patients. Read More

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http://dx.doi.org/10.4103/iju.IJU_306_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334577PMC
January 2019
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