7,183 results match your criteria Bladder Cystitis


High-Density Surface Electromyography Assessment of Pelvic Floor Dysfunction in Women with Interstitial Cystitis/Bladder Pain Syndrome.

J Urol 2020 Jul 6:101097JU0000000000001237. Epub 2020 Jul 6.

University of Houston, Department of Biomedical Engineering, Houston, Texas.

Purpose: Up to 85% of women with interstitial cystitis/bladder pain syndrome (IC/BPS) have pelvic floor dysfunction and hypertonicity. Current evaluation methodologies lack objective measures of pelvic floor muscle (PFM) activity. We examined the ability of utilizing intravaginal high-density surface electromyography (HD-sEMG) to quantitatively, objectively and non-invasively map PFM activity and innervation zone (IZ) locations in IC/BPS patients. Read More

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http://dx.doi.org/10.1097/JU.0000000000001237DOI Listing

Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infection and the potential role of the urinary microbiome.

Post Reprod Health 2020 Jun;26(2):87-90

Urogynaecology Unit, St Mary's Hospital, Imperial College, London, London, UK.

Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infections carry significant burden for those affected. As women enter the menopause, other factors may influence how these conditions manifest. The urinary microbiome has shown that the urine contains extensive numbers of bacteria. Read More

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http://dx.doi.org/10.1177/2053369120936426DOI Listing

Swiss consensus recommendations on urinary tract infections in children.

Eur J Pediatr 2020 Jul 3. Epub 2020 Jul 3.

Paediatrics, Lucerne Children's Hospital, Cantonal Hospital Lucerne, Spitalstrasse, 6000, Luzern 16, Switzerland.

The kidneys and the urinary tract are a common source of infection in children of all ages, especially infants and young children. The main risk factors for sequelae after urinary tract infections (UTI) are congenital anomalies of the kidney and urinary tract (CAKUT) and bladder-bowel dysfunction. UTI should be considered in every child with fever without a source. Read More

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http://dx.doi.org/10.1007/s00431-020-03714-4DOI Listing

Tropisetron ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats.

Eur J Pharmacol 2020 Jun 30:173310. Epub 2020 Jun 30.

Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Hemorrhagic cystitis is one of the most important complications of cyclophosphamide, a drug widely used in cancer chemotherapy and bone marrow transplantation. 5-HT antagonists are anti-emetic agents and have been shown to have notable anti-inflammatory and antioxidant properties. This study was designed to investigate the possible protective effects of tropisetron against cyclophosphamide-induced hemorrhagic cystitis in rats. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173310DOI Listing

Relevance of the endoscopic evaluation in the diagnosis of Bladder Pain Syndrome/Interstitial Cystitis.

Urology 2020 Jun 30. Epub 2020 Jun 30.

Urology Clinic, University of Udine and University Hospital "Santa Maria della Misericordia" - Udine - Italy.

Objective: In 2008 the European Society for the Study of Interstitial Cystitis (ESSIC) established the diagnostic criteria and classification of Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC), based on clinical features and cystoscopy results. The present study aims to assess the relevance of the endoscopic evaluation in clinically suspected cases of BPS/IC, using ESSIC criteria.

Methods: . Read More

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http://dx.doi.org/10.1016/j.urology.2020.06.032DOI Listing

Interstitial Cystitis or Painful Bladder Syndrome in a Premenopausal Female Precipitated by Oral Combined Contraceptives.

Cureus 2020 May 29;12(5):e8348. Epub 2020 May 29.

Clinical Sciences, University of Central Florida College of Medicine, Orlando, USA.

It has been well documented that female sex is a significant risk factor for the development of various autoimmune diseases. While the reason for this has been debated, one well-regarded theory is that increased estrogen and decreased testosterone play a role in this predisposition. Interstitial cystitis (IC), also known as painful bladder syndrome (PBS), is an autoimmune disorder that affects over nine million women in the United States. Read More

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http://dx.doi.org/10.7759/cureus.8348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325412PMC

The effect of O-1602, a GPR55 agonist, on the cyclophosphamide-induced rat hemorrhagic cystitis.

Eur J Pharmacol 2020 Jun 29:173321. Epub 2020 Jun 29.

Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005, Warsaw, Poland.

The goal of our study was to determine whether GPR55 agonists, O-1602, could reverse the cyclophosphamide (CYP)-induced changes in cystometric and inflammatory parameters, indicative of the development of bladder inflammation and overactivity. If confirmed, the stimulation of novel cannabinoid receptor - GPR55, could be a reasonable strategy as a treatment of CYP-induced haemorrhagic cystitis. The experiments were conducted in female Wistar rats. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173321DOI Listing

Biopsy at flexible cystoscopy: is it worthwhile?

Ir J Med Sci 2020 Jul 1. Epub 2020 Jul 1.

Department of Urology, University Hospital Galway, Newcastle Road, Galway, Ireland.

Introduction: Flexible cystoscopy is the gold standard for diagnosis and surveillance of bladder carcinoma. Most flexible cystoscopes feature a working channel allowing for bladder biopsy and diathermy if a suspicious lesion is observed. However, the working channel permits only small instruments which limit the volume of material retrieved for histological analysis. Read More

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http://dx.doi.org/10.1007/s11845-020-02284-6DOI Listing

Idiopathic Pneumatosis of Small Bowel and Bladder.

Cureus 2020 May 27;12(5):e8313. Epub 2020 May 27.

Surgery, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA.

An 81-year-old woman presented with multiple episodes of loose bowel movements. CT scan of the abdomen and pelvis revealed pneumatosis cystoides intestinalis and asymptomatic emphysematous cystitis. The patient had an extensive workup with no obvious identified pathology to explain diffuse pneumatosis of the small bowel and bladder. Read More

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http://dx.doi.org/10.7759/cureus.8313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320656PMC

Capillaria plica in Red Foxes (Vulpes vulpes) from Serbia: Epidemiology and Diagnostic Approaches to Urinary Capillariosis in Domestic Carnivores.

Acta Parasitol 2020 Jun 29. Epub 2020 Jun 29.

Department of Parasitology, Faculty of Veterinary Medicine, University of Belgrade, Beograd, Serbia.

Purpose: This study aimed to determine the presence of C. plica in red foxes and to point out the possibilities of different diagnostic methods, that could be used for diagnosis of urinary capillariosis in domestic carnivores.

Methods: Seventeen red foxes from hunting grounds in the Kolubara District, Republic of Serbia, were examined in February 2019. Read More

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http://dx.doi.org/10.1007/s11686-020-00244-9DOI Listing

[Method of complex therapy of chronic cystitis].

Urologiia 2020 Jun(3):39-45

Kazan State Medical University of the Ministry of Health of Russia, Kazan, Russia.

Aim: To assess the effectiveness of hydroxyethyldimethyldihydropyrimidine (trade name Xymedone) in the treatment of chronic recurrent cystitis in women.

Materials And Methods: The study included 30 patients (the main group) with a confirmed diagnosis of chronic cystitis (HC) with a recurrence rate of at least 3 times a year, the average age of the patients was 46.0+/-2. Read More

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Poor bladder compliance due to malacoplakia with xanthogranulomatous cystitis: A case report.

Medicine (Baltimore) 2020 Jun;99(26):e20852

Continence Research Clinic, The Central Hosptial of Shaoyang, Shaoyang, China.

Rationale: Either malacoplakia or xanthogranulomatous cystitis (XC) is a rare chronic infection disease of urinary bladder, which often mimics bladder masses undifferentiated from malignance and results in severe lower urinary tract symptoms. The malacoplakia combined with XC is even rarer in the literature.

Patient Concerns: A 64-year-old female, who presented with nocturia, frequency of micturition, severe urgency with occasional urinary incontinence, and recurrent hematuria for >2 years, was diagnosed with azotemia and anemia. Read More

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http://dx.doi.org/10.1097/MD.0000000000020852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328967PMC

Ceftriaxone inhibits stress-induced bladder hyperalgesia and alters cerebral micturition and nociceptive circuits in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study.

Neurourol Urodyn 2020 Jun 23. Epub 2020 Jun 23.

Department of Urology, University of Southern California, Los Angeles, California.

Aims: Emotional stress plays a role in the exacerbation and development of interstitial cystitis/bladder pain syndrome (IC/BPS). Given the significant overlap of brain circuits involved in stress, anxiety, and micturition, and the documented role of glutamate in their regulation, we examined the effects of an increase in glutamate transport on central amplification of stress-induced bladder hyperalgesia, a core feature of IC/BPS.

Methods: Wistar-Kyoto rats were exposed to water avoidance stress (WAS, 1 hour/day x 10 days) or sham stress, with subgroups receiving daily administration of ceftriaxone (CTX), an activator of glutamate transport. Read More

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http://dx.doi.org/10.1002/nau.24424DOI Listing

Bioinformatics Approach for Identifying Novel Biomarkers and Their Signaling Pathways Involved in Interstitial Cystitis/Bladder Pain Syndrome with Hunner Lesion.

J Clin Med 2020 Jun 21;9(6). Epub 2020 Jun 21.

Department of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center (MCRC), and Incurable Disease Animal Model & Stem Cell Institute (IDASI), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.

The complexity of interstitial cystitis/bladder pain syndrome (IC/BPS) has led to considerable uncertainty in terms of diagnosis and prevalence of the condition. Here, we try to identify the IC/BPS-associated genes through an integrated analysis of Gene Expression Omnibus (GEO) datasets and confirm experimentally to predict the pathologic diagnosis of IC/BPS. Data mining analysis of GEO datasets (GSE621, GSE11783, GSE28242, and GSE57560) revealed a total of 53 (51 upregulated and two downregulated) common differentially expressed genes (DEGs) in IC/BPS. Read More

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http://dx.doi.org/10.3390/jcm9061935DOI Listing

Re: Update on the Pathophysiology of Interstitial Cystitis/Bladder Pain Syndrome.

Authors:
Alan J Wein

J Urol 2020 Jun 22:101097JU000000000000118002. Epub 2020 Jun 22.

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http://dx.doi.org/10.1097/JU.0000000000001180.02DOI Listing

Dosimetric predictors of genitourinary toxicity from a phase I trial of prostate bed stereotactic body radiation therapy.

Pract Radiat Oncol 2020 Jun 17. Epub 2020 Jun 17.

Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA, USA. Electronic address:

Purpose: To analyze dose-volume parameters associated with genitourinary (GU) toxicity from a phase I clinical trial of prostate bed stereotactic body radiotherapy (PB-SBRT).

Methods: Patients were treated in escalating dose levels of 35 Gy, 40 Gy, and 45 Gy, over 5 fractions. Data from all 26 patients enrolled on the protocol were analyzed using multiple dose-volume cutpoints for multiple GU organs at risk. Read More

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http://dx.doi.org/10.1016/j.prro.2020.06.004DOI Listing

Use of Botulinum Toxin in the Genitourinary System.

Handb Exp Pharmacol 2020 Jun 20. Epub 2020 Jun 20.

Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.

Botulinum toxin injection has been widely accepted by the urology and urogynecology medical communities as a safe and effective treatment for refractory urinary incontinence. There are two approved genitourinary indications for botulinum toxin. OnabotulinumtoxinA (onaBoNTA) 200 U for the treatment of urinary incontinence due to detrusor overactivity associated with a neurologic condition (e. Read More

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http://dx.doi.org/10.1007/164_2019_308DOI Listing

[Urolithiasis in a pet rat (Rattus norvegicus)].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2020 Jun 18;48(3):203-208. Epub 2020 Jun 18.

Praxis für kleine Heimtiere, Berlin.

Uroliths are uncommon findings in rats. This report describes a case of a neutered male rat with dysuria due to an infectious cystitis as well as an urolith of the urinary bladder consisting of struvite and whewellit. Following cystotomy as well as treatment with antibiotics and analgetics the rat recovered rapidly. Read More

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http://dx.doi.org/10.1055/a-1110-4336DOI Listing

Botulinum Toxin Paves the Way for the Treatment of Functional Lower Urinary Tract Dysfunction.

Authors:
Hann-Chorng Kuo

Toxins (Basel) 2020 Jun 14;12(6). Epub 2020 Jun 14.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Tzu Chi University, Hualien 970, Taiwan.

Botulinum toxin A (BoNT-A) is a potent protein that can selectively modulate neurotransmission from nerve endings, resulting in the blocking of neurotransmitter releases and causing muscular paralysis [... Read More

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http://dx.doi.org/10.3390/toxins12060394DOI Listing
June 2020
2.480 Impact Factor

Non-bladder centric interstitial cystitis/bladder pain syndrome phenotype is significantly associated with co-occurring endometriosis.

Can J Urol 2020 Jun;27(3):10257-10262

Department of Urology/Pelvic Health, Wake Forest Baptist Health, Winston-Salem, North Carolina, USA.

Introduction: Interstitial cystitis/bladder pain syndrome (IC/BPS) and endometriosis are coexistent diagnoses in 48%-65% of women with chronic pelvic pain (CPP), suggesting that dual screening may be warranted. To further investigate the clinical relationship and risk factors between these two conditions, we performed a retrospective review of our large IC/BPS patient data registry.

Materials And Methods: We evaluated IC/BPS patients who were prospectively enrolled into our registry who completed validated questionnaires and underwent therapeutic hydrodistension, during which anesthetic bladder capacity (BC) and Hunner's lesion (HL) status were recorded. Read More

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Editorial Comment to Clinical guidelines for interstitial cystitis/bladder pain syndrome.

Authors:
Norifumi Sawada

Int J Urol 2020 Jul 16;27(7):589-590. Epub 2020 Jun 16.

Department of Urology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.

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http://dx.doi.org/10.1111/iju.14271DOI Listing

Aberrantly glycosylated integrin α3β1 is a unique urinary biomarker for the diagnosis of bladder cancer.

Aging (Albany NY) 2020 Jun 13;12(11):10844-10862. Epub 2020 Jun 13.

Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Bladder cancer (BC) is the most common malignancy of the urinary tract. We developed a new and ELISA kit for detecting aberrantly glycosylated integrin α3β1 (AG31) in human urine. We analysed urine samples (n=408) of patients with BC, renal cell carcinoma (RCC), prostate cancer (PC), cystitis, nephritis, and prostatitis from two centres in China. Read More

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http://dx.doi.org/10.18632/aging.103297DOI Listing
June 2020
6.432 Impact Factor

Platelet-Rich Plasma Ameliorates Cyclophosphamide-Induced Acute Interstitial Cystitis/Painful Bladder Syndrome in a Rat Model.

Diagnostics (Basel) 2020 Jun 8;10(6). Epub 2020 Jun 8.

Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.

Background: Interstitial cystitis/painful bladder syndrome (IC/PBS) could be treated to ameliorate urothelial injury. Here, we investigated the efficacy of intravesical instillation with platelet-rich plasma (PRP) and hyaluronic acid for acute IC/PBS.

Methods: The effects of PRP and hyaluronic acid on the proliferation of normal human fibroblast cells (HFCs) were assessed. Read More

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http://dx.doi.org/10.3390/diagnostics10060381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344907PMC

Botulinum toxin in low urinary tract disorders - over 30 years of practice (Review).

Exp Ther Med 2020 Jul 15;20(1):117-120. Epub 2020 Apr 15.

'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Botulinum toxin is a substance produced by Clostridium Botulinum and is responsible for human botulism. This substance is a poison, a neurotoxin, but used in limited quantities it can be a cure for some diseases. It is well connected to a large variety of medical applications. Read More

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http://dx.doi.org/10.3892/etm.2020.8664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271717PMC

Urease-Powered Polydopamine Nanomotors for Intravesical Therapy of Bladder Diseases.

ACS Nano 2020 Jun 8;14(6):6683-6692. Epub 2020 Jun 8.

Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Korea.

Intravesical therapeutic delivery has been extensively investigated for various bladder diseases such as bladder cancer, overactive bladder, urinary incontinence, and interstitial cystitis. However, conventional drug carriers have a low therapeutic delivery efficiency because of the passive diffusion of drug molecules in a bladder and the rapid clearance by periodic urination. Here, we report biocompatible and bioavailable enzyme-powered polymer nanomotors which can deeply penetrate into a mucosa layer of the bladder wall and remain for a long-term period in the bladder. Read More

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http://dx.doi.org/10.1021/acsnano.9b09726DOI Listing

Urolithiasis and cystitis associated with Staphylococcus delphini group A and mortality in post-weaning mink kits (Neovison vison).

Vet Microbiol 2020 Jun 5;245:108706. Epub 2020 May 5.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 3, 1870 Frederiksberg C, Denmark.

Mortality of mink kits represents a significant loss to production. However, causes of post-weaning mortality in mink kits in modern Danish mink production systems are still relatively poorly documented. We performed a cross-sectional mortality study on eight Danish mink farms including 1893 post mortem examinations of mink kits found dead or euthanized. Read More

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http://dx.doi.org/10.1016/j.vetmic.2020.108706DOI Listing

Analysis of viruses present in urine from patients with interstitial cystitis.

Virus Genes 2020 Aug 23;56(4):430-438. Epub 2020 May 23.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.

The question of whether some cases of interstitial cystitis may have an infectious etiology has been debated for some time. Previous studies have looked for the presence of certain specific viruses, but generally did not use the types of sensitive and unbiased approaches that are currently available. As part of the MAPP (Multidisciplinary Approach to the Study of Chronic Pelvic Pain) Research Network, we examined urine specimens from interstitial cystitis patients who provided specimens over time and also reported various symptoms at the time of urine collection. Read More

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http://dx.doi.org/10.1007/s11262-020-01767-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339973PMC

Urinary tract infections in children.

Lancet 2020 05;395(10237):1659-1668

Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Urinary tract infections (UTIs) in children are among the most common bacterial infections in childhood. They are equally common in boys and girls during the first year of life and become more common in girls after the first year of life. Dividing UTIs into three categories; febrile upper UTI (acute pyelonephritis), lower UTI (cystitis), and asymptomatic bacteriuria, is useful for numerous reasons, mainly because it helps to understand the pathophysiology of the infection. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)30676-0DOI Listing

Extracellular vesicles enhance oxidative stress through P38/NF-kB pathway in ketamine-induced ulcerative cystitis.

J Cell Mol Med 2020 May 22. Epub 2020 May 22.

Department of Urology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Long-term abuse of ketamine causes ketamine-induced cystitis. The functional alterations of bladder epithelial cells in microenvironment during cystitis remain poorly understood. Here, we explored extracellular vesicles (EV) alteration in ketamine-induced toxicity. Read More

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http://dx.doi.org/10.1111/jcmm.15397DOI Listing

Avoiding Urinary Catheterization in Patients Undergoing Atrial Fibrillation Catheter Ablation.

J Atr Fibrillation 2019 Dec 31;12(4):2221. Epub 2019 Dec 31.

St Vincent Medical Group, Clinical Cardiac Electrophysiology, Indianapolis, IN.

Purpose: Indwelling urinary catheters are commonly inserted when administering general anesthesia. However, there are significant risks to routine IUC insertion. We compared urinary and other outcomes in a population of patients undergoing atrial fibrillation (AF) ablation with or without IUC. Read More

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http://dx.doi.org/10.4022/jafib.2221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237079PMC
December 2019

TRPV4 Mediates Acute Bladder Responses to Bacterial Lipopolysaccharides.

Front Immunol 2020 6;11:799. Epub 2020 May 6.

Laboratory for Ion Channel Research, Department of Cellular and Molecular Medicine, VIB Center for Brain & Disease Research, Leuven, Belgium.

Urinary tract infections (UTI) affect a large proportion of the population, causing among other symptoms, more frequent and urgent micturition. Previous studies reported that the gram-negative bacterial wall component lipopolysaccharides (LPS) trigger acute epithelial and bladder voiding responses, but the underlying mechanisms remain unknown. The cation channel TRPV4 is implicated in the regulation of the bladder voiding. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218059PMC

A comprehensive evaluation of differentially expressed mRNAs and lncRNAs in cystitis glandularis with gene ontology, KEGG pathway, and ceRNA network analysis.

Transl Androl Urol 2020 Apr;9(2):232-242

Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.

Background: Cystitis glandularis (CG) is a proliferative disorder of the urinary bladder characterized by transitional cells that have undergone glandular metaplasia. The underlying mechanism associated with this transformation is poorly understood.

Methods: The expression of messenger RNA (mRNA) and long non-coding RNA (lncRNA) from normal bladder mucosa and CG were compared using microarray analysis. Read More

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http://dx.doi.org/10.21037/tau.2020.03.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214972PMC

Hemorrhagic Cystitis after Haploidentical Transplantation with Post-Transplantation Cyclophosphamide: Protective Effect of MESNA Continuous Infusion.

Biol Blood Marrow Transplant 2020 May 15. Epub 2020 May 15.

Epidemiology and Public Health, Universidad CES, Medellín, Colombia.

Hemorrhagic cystitis (HC) is an important complication after haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with post-transplantation cyclophosphamide (PT-CY). Sodium 2-mercaptoethanesulfonate (MESNA) can prevent bladder injury when given with PT-CY. However, the best way to deliver MESNA is not known. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.04.028DOI Listing

α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice.

Naunyn Schmiedebergs Arch Pharmacol 2020 May 15. Epub 2020 May 15.

Medicinal Plants Research Center, Federal University of Piauí, Av. Nossa Senhora de Fátima s/n, Teresina, PI, 64049-550, Brazil.

Hemorrhagic cystitis (HC) is the major dose-limiting adverse effect of the clinical use ifosfamide (IFOS). The incidence of this side effect can be as high as 75%. Mesna has been used to reduce the risk of HC, although 5% of patients who get IFOS treatment may still suffer from HC. Read More

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http://dx.doi.org/10.1007/s00210-020-01869-3DOI Listing

Cranberry capsules are not superior to placebo capsules in managing acute non-haemorrhagic radiation cystitis in prostate cancer patients: A phase III double blinded randomised placebo controlled clinical trial.

Radiother Oncol 2020 May 13;149:117-123. Epub 2020 May 13.

Radiation Oncology Department, Southern Blood and Cancer Centre, Dunedin Hospital, New Zealand.

Purpose: Acute radiation cystitis affects the quality of life of many prostate cancer patients. A previous pilot study suggested that cranberry capsules may decrease some of the symptoms of acute radiation cystitis. Here we further test their effectiveness in a multicentre double blinded placebo-controlled clinical trial. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.05.006DOI Listing

Successful Treatment of Urinary Bladder Hemangiosarcoma by Partial Cystectomy in a Dog.

J Am Anim Hosp Assoc 2020 Jul/Aug;56(4):231-235. Epub 2020 May 15.

From the University of Florida, Gainesville, Florida.

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http://dx.doi.org/10.5326/JAAHA-MS-6910DOI Listing

Pathogenicity of BK virus on the urinary system.

Cent European J Urol 2020 27;73(1):94-103. Epub 2020 Feb 27.

Department of Vascular, General and Transplantation Surgery, Wrocław Medical University, Wrocław, Poland.

Introduction: The polyomaviruses are omnipresent in nature. The major sites of BK virus appearance are the kidney tubular epithelial cells and urinary bladder surface transitional cells.

Material And Methods: A literature search according to PRISMA guidelines within the Medline database was conducted in July 2019 for articles presenting data about BK virus in urologic aspect without setting time limits, using the terms 'BK virus' in conjunction with transplantation, nephropathy, stenosis, cancer, bladder, prostate, kidney. Read More

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http://dx.doi.org/10.5173/ceju.2020.0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203775PMC
February 2020

Pain reduction realized with extracorporeal shock wave therapy for the treatment of symptoms associated with interstitial cystitis/bladder pain syndrome-A prospective, multicenter, randomized, double-blind, placebo-controlled study.

Neurourol Urodyn 2020 06 11;39(5):1505-1514. Epub 2020 May 11.

Department of Urology, Hualien Tzu Chi General Hospital, Tzu Chi Medical Foundation, Buddhist Tzu Chi University, Hualien, Taiwan.

Aims: Extracorporeal shock wave therapy (ESWT) inhibited bladder inflammation and pain in preclinical studies. We assessed ESWT for the treatment of refractory interstitial cystitis/bladder pain syndrome (IC/BPS).

Methods: This double-blind, randomized, placebo-controlled physician-initiated study enrolled 54 patients with IC/BPS. Read More

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http://dx.doi.org/10.1002/nau.24382DOI Listing
June 2020
2.873 Impact Factor

Physical exam in the evaluation of bladder pain syndrome (BPS): A key component for differential diagnosis.

Arch Esp Urol 2020 May;73(4):281-292

Departamento de Urología. Hospital Universitario La Fe. Valencia. España.

Objectives: To describe in more detail the usual clinical practice regarding physical examination (PE) in Bladder Pain Syndrome (BPS) and to evaluate if the performance of PE relates to changes in severity of symptoms and in Health Related Quality of Life (HRQoL).

Material And Methods: Epidemiological, observational, national and multicentric study that included 319 patients with BPS (79 of new diagnosis and 240 in follow-up). Demographic and clinical data were collected. Read More

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A Comprehensive Review of the Diagnosis, Treatment, and Management of Urologic Chronic Pelvic Pain Syndrome.

Curr Pain Headache Rep 2020 May 6;24(6):27. Epub 2020 May 6.

Department of Anesthesiology, Creighton University School of Medicine, Omaha, NE, USA.

Purpose Of Review: Urologic chronic pelvic pain syndrome (UCPPS) is a chronic, noncyclic pain condition which can lead to significant patient morbidity and disability. It is defined by pain in the pelvic region, lasting for greater than 3 to 6 months, with no readily identifiable disease process. The aim of this review is to provide a comprehensive update of diagnosis and treatment of UCPPS. Read More

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http://dx.doi.org/10.1007/s11916-020-00857-9DOI Listing

Changes in uroplakin expression in the urothelium of patients with ulcerative interstitial cystitis/bladder pain syndrome.

Investig Clin Urol 2020 May 20;61(3):304-309. Epub 2020 Apr 20.

Department of Urology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: We evaluated changes in the expression of uroplakin (UP) in the urothelium of patients with ulcerative interstitial cystitis/bladder pain syndrome (IC/BPS).

Materials And Methods: Bladder samples were collected from 19 patients with ulcerative IC/BPS who were treated with augmentation ileocystoplasty and from 5 control patients. Frequency-volume charts, the pain visual analogue scale (VAS), and the O'Leary-Sant interstitial cystitis symptom index (ICSI) and problem index (ICPI) were used to evaluate the patients' symptoms preoperatively. Read More

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http://dx.doi.org/10.4111/icu.2020.61.3.304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189107PMC

[Preoperative intensity-modulated radiotherapy of rectal cancers: Relevance and modalities].

Cancer Radiother 2020 Jul 28;24(4):345-353. Epub 2020 Apr 28.

Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, BP 5026, 63011 Clermont-Ferrand cedex 1, France. Electronic address:

Preoperative radiotherapy boosted by chemotherapy is a recommended treatment in locally advanced rectal cancers. This treatment is delivered by three dimensional conformal irradiation, which is usually well tolerated but can induce potential toxicity such as rectitis, cystitis and hematologic adverse effects. Intensity-modulated radiotherapy, widely available nowadays, allows optimization of volume covering and sparing of organs at risk such as bladder and bone marrow. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.11.005DOI Listing

The role of bladder instillation in the treatment of bladder pain syndrome: Is intravesical treatment an effective option for patients with bladder pain as well as LUTS?

Int Urogynecol J 2020 Jul 1;31(7):1387-1392. Epub 2020 May 1.

St Mary's Hospital, Imperial College NHS Trust, London, UK.

The aetiology of bladder pain syndrome/interstitial cystitis is still unknown. Numerous mechanisms have been proposed and treatments targeting various aspects of these are used. This review looks at the existing evidence on bladder instillations and whether they could be used in the treatment of lower urinary tract symptoms as well. Read More

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http://dx.doi.org/10.1007/s00192-020-04303-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306012PMC

Development and validation of a predictive nomogram for the risk of recurrence in patients with cystitis glandularis.

Ann Transl Med 2020 Mar;8(6):352

Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.

Background: Most patients with cystitis glandularis (CG) suffer from recurrence after primary treatment. Therefore, we performed this multicenter study to clarify the recurrent risk factors and constructed a predictive nomogram for the risk of recurrence. Also, we try to investigate the correlation between CG and bladder cancer. Read More

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http://dx.doi.org/10.21037/atm.2020.02.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186700PMC

[Combined prophylaxis of recurrent lower urinary tract infections in children and pregnant women].

Authors:
S V Kotov R A Perov

Urologiia 2020 Apr(2):122-126

Department of Urology and Andrology of Medical Faculty of N.I. Pirogov RNRMU of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.

The use of the combined herbal preparation Cystenium II for the prevention of recurrent lower urinary tract infections, including those in children and pregnant women, is described in the review. The etiological component of infectious and inflammatory diseases of the lower urinary tract and specific features of the interaction of microorganisms with bladder mucosa were studied. A detailed analysis of pharmacodynamic effects of Cysteniums II components is provided. Read More

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[Systemic enzyme therapy for treatment of women with chronic recurrent bacterial cystitis].

Urologiia 2020 Apr(2):35-40

Department of Urology of FGBOU VO Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia.

Introduction: In most cases, treatment of infectious and inflammatory diseases, including lower urinary tract infections, includes antibacterial drugs. However, their efficiency decreases every year. The absence of new groups of antibiotics makes it necessary to develop alternative treatment schemes and methods for improving efficiency of existing drugs. Read More

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[Experimental evaluation of interaction of the nerve growth factor and mast cells in patients with interstitial cystitis/bladder pain syndrome].

Authors:
R F Sholan

Urologiia 2020 Apr(2):31-34

Republican Medical Diagnostic Center, Baku, Azerbaijan.

Aim: to evaluate the level of nerve growth factor (NGF) in the blood and urine and mast cell infiltration of the bladder wall in a model of interstitial cystitis/bladder pain syndrome (IC/BPS) and to analyze their relationships.

Materials And Methods: IC/BPS modeling was performed on 38 female rabbits, which were divided into 4 groups. In the group 1, IC/BPS was simulated by an instillation of 70% alcohol into the bladder, while in group 2 and 3 animals own urine and normal saline were injected into the bladder wall. Read More

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The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor.

BMC Urol 2020 Apr 29;20(1):48. Epub 2020 Apr 29.

Centre for Urology Research, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, 4226, Australia.

Background: Inflammation is often associated with several bladder dysfunctions, including overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/PBS). As such, inflammation of the bladder and the actions of inflammatory mediators may contribute to the development of urinary symptoms. This study assessed the actions of PGE, PGF, PGD, TXA, and PGI on urinary bladder urothelium with lamina propria (U&LP), and detrusor smooth muscle. Read More

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http://dx.doi.org/10.1186/s12894-020-00619-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191740PMC