6,833 results match your criteria Bladder Cystitis


UCA1 promotes cell viability, proliferation and migration potential through UCA1/miR-204/CCND2 pathway in primary cystitis glandularis cells.

Biomed Pharmacother 2019 Apr 15;114:108872. Epub 2019 Apr 15.

Reproductive Medicine Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China. Electronic address:

Cystitis glandularis (CG) is an unusual proliferative disorder of the urinary bladder. Increasing evidences demonstrated that long non-coding RNAs (lncRNAs) play important roles in a variety of cellular progresses. However, there are rarely reports about the role and underlying molecular mechanism of lncRNAs in CG. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108872DOI Listing

[Comparison of effectiveness and complications between two different methods of augmentation cystoplasty].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):293-297

Department of Urology, Peking University People's Hospital, Beijing 100044, China.

Objective: To compare the effectiveness and complications between enterocystoplasty and small intestinal submucosa (SIS) cystoplasty through follow-ups of patients with augmentation cystoplasty in Peking University People's Hospital, offering alternative approach for future treatment.

Methods: In this study, retrospective analyses were carried out in 10 patients who underwent enterocystoplasty or SIS cystoplasty in Peking University People's Hospital from November 2011 to December 2016. Clinical data were collected including medical history, surgical procedures, laboratory examinations and complications. Read More

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April 2019
1 Read

Functional effects of blocking VEGF/VEGFR2 signaling in the rat urinary bladder in acute and chronic CYP-induced cystitis.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Neurological Sciences, University of Vermont, United States.

High expression of vascular endothelial growth factor (VEGF) is associated with immature angiogenesis within the urinary bladder wall and bladder afferent nerve sensitization leading to visceral hyperalgesia and pelvic pain. Research suggests a shift in VEGF alternative splice variant (VEGF-Aa, VEGF-Ab) expression with several pathologies (e.g. Read More

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http://dx.doi.org/10.1152/ajprenal.00083.2019DOI Listing
April 2019
1 Read

Female lower urinary tract microbiota do not associate with IC/PBS symptoms: a case-controlled study.

Int Urogynecol J 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology and Immunology, Loyola University Chicago, Health Sciences Division, Stritch School of Medicine, Maywood, IL, 60153, USA.

Introduction And Hypothesis: The current etiology of interstitial cystitis/painful bladder syndrome (IC/PBS) is poorly understood and multifactorial. Recent studies suggest the female urinary microbiota (FUM) contribute to IC/PBS symptoms. This study was designed to determine if the FUM, analyzed using mid-stream voided urine samples, differs between IC/PBS patients and controls. Read More

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http://dx.doi.org/10.1007/s00192-019-03942-9DOI Listing

Neuregulin-1-ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide-induced cystitis.

Neurourol Urodyn 2019 Apr 15. Epub 2019 Apr 15.

Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Aims: Central sensitization playsimportant roles in cyclophosphamide (CYP)-induced cystitis. In addition, as a visceral pain, CYP-induced chronic pain shares common pathophysiological mechanisms with neuropathic pain. Previous studies demonstrated that neuregulin-1 (Nrg1)-ErbB signaling contributes to neuropathic pain, but whether and how this signaling influences mechanical allodynia in CYP-induced cystitis is unclear. Read More

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http://dx.doi.org/10.1002/nau.24005DOI Listing
April 2019
1 Read

Oxygen Venous Embolism After Hydrogen Peroxide Use During Percutaneous Nephrolithotomy.

J Endourol Case Rep 2019 18;5(1):25-27. Epub 2019 Mar 18.

Department of Urology, George Washington University Medical School, Washington, District of Columbia.

Hydrogen peroxide (HO) is a common antiseptic that is available without a prescription in the United States, and it is indicated for minor dermal abrasion; mouth, gum, or dental irritations; and removal of oral secretion. Several other medical uses have also been described, including clot dissolution during endoscopic gastrointestinal evaluation, cleansing of orthopedic surgical sites, and bladder irrigation. However, these uses of HO, as well as high-dose ingestion, have been associated with a wide variety of medical complications, including but not limited to air pulmonary embolism and stroke. Read More

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https://www.liebertpub.com/doi/10.1089/cren.2018.0111
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http://dx.doi.org/10.1089/cren.2018.0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461058PMC
March 2019
2 Reads

Single postoperative instillation for non-muscle invasive bladder cancer: are there still any indication?

Transl Androl Urol 2019 Feb;8(1):76-84

Klinik für Urologie, Luzerner Kantonsspital, Spitalstrasse 2, Lucerne, Switzerland.

Intravesical chemotherapeutical agents after transurethral resection have shown to be effective in reducing the risk of recurrence and progression during the follow up. Specifically, an early single chemotherapeutical instillation (SI) might play an important role but the efficacy of this treatment has been questioned. For these reasons, we sought to review and summarize the current evidence with a non-systematic Medline/PubMed literature search. Read More

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http://dx.doi.org/10.21037/tau.2018.08.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414349PMC
February 2019
1 Read

Single nucleotide polymorphism analysis in interstitial cystitis/painful bladder syndrome.

PLoS One 2019 11;14(4):e0215201. Epub 2019 Apr 11.

Clinics Hospital, Department of Urology, University of de Sao Paulo Medical School, Sao Paulo, Brazil.

Introduction: Interstitial Cystitis (IC) is a chronic condition diagnosed based on the presence of symptoms, such as suprapubic/ pelvic pain, pressure or discomfort in association with urgency and increased urinary frequency. Confusable diseases must be excluded. However, there is no objective test or marker to establish the presence of the disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215201PLOS
April 2019
1 Read

The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections.

Polymers (Basel) 2018 Mar 5;10(3). Epub 2018 Mar 5.

Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia.

The most frequent diseases of the urinary bladder are bacterial infections and bladder cancers. For both diseases, very high recurrence rates are characteristic: 50⁻80% for bladder cancer and more than 50% for bladder infections, causing loss of millions of dollars per year for medical treatment and sick leave. Despite years of searching for better treatment, the prevalence of bladder infections and bladder cancer remains unchanged and is even increasing in recent years. Read More

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http://dx.doi.org/10.3390/polym10030265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414971PMC

Concomitant primary ovarian paraganglioma neuroendocrinal differentiated urothelial tumor in a BOTOX-injected bladder: A case report.

Int J Surg Case Rep 2019 Mar 28;57:122-125. Epub 2019 Mar 28.

Urology Department, Urology and Nephrology Center, Mansoura University, Egypt.

Introduction: There is no reported data for patients with malignant bladder Botox injection related outcomes. Herein, we reported effect of Botox injection in case of BCG cystitis. In addition, reporting of rare incidence of both primary neuroendocrine differentiation of bladder tumor and primary ovarian paraganglioma post cystectomy. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447811PMC
March 2019
1 Read

Autonomic neurophysiologic implications of disorders comorbid with bladder pain syndrome vs myofascial pelvic pain.

Neurourol Urodyn 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Aims: The neuropathophysiology of a debilitating chronic urologic pain condition, bladder pain syndrome (BPS), remains unknown. Our recent data suggests withdrawal of cardiovagal modulation in subjects with BPS, in contrast to sympathetic nervous system dysfunction in another chronic pelvic pain syndrome, myofascial pelvic pain (MPP). We evaluated whether comorbid disorders differentially associated with BPS vs MPP shed additional light on these autonomic differences. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/nau.23995
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http://dx.doi.org/10.1002/nau.23995DOI Listing
April 2019
6 Reads

Risk Factors for Interstitial Cystitis in the General Population and in Individuals With Depression.

Int Neurourol J 2019 Mar 31;23(1):40-45. Epub 2019 Mar 31.

Janssen Research and Development, Titusville, NJ, USA.

Purpose: To identify risk factors for interstitial cystitis (IC), a chronic bladder disorder that may have a significant detrimental impact on quality of life, in the general population and in individuals with depression.

Methods: This was a comparative study using a US claims database. Adults who had records of a visit to the health system in 2010 or later were included. Read More

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http://dx.doi.org/10.5213/inj.1836182.091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449659PMC
March 2019
1 Read

Electrofulguration in the advanced management of antibiotic-refractory recurrent urinary tract infections in women.

Int J Urol 2019 Apr 3. Epub 2019 Apr 3.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Objective: To evaluate the long-term efficacy of electrofulguration in women with recurrent urinary tract infections.

Methods: After institutional review board approval, a retrospective study of women who underwent electrofulguration alone was carried out. All patients had recurrent urinary tract infections defined as three or more urinary tract infections/year, and a preoperative office cystoscopy showing inflammatory lesions, categorized by location: urethra, bladder neck, trigone and beyond the trigone. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/iju.13963
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http://dx.doi.org/10.1111/iju.13963DOI Listing
April 2019
8 Reads

Urinary K promotes irritative voiding symptoms and pain in the face of urothelial barrier dysfunction.

Sci Rep 2019 Apr 2;9(1):5509. Epub 2019 Apr 2.

Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

The internal surface of the bladder is lined by the urothelium, a stratified epithelium that forms an impermeable barrier to water and urine constituents. Abnormalities in the urothelial barrier have been described in certain forms of cystitis and were hypothesized to contribute to irritative voiding symptoms and pain by allowing the permeation of urinary K into suburothelial tissues, which then alters afferent signaling and smooth muscle function. Here, we examined the mechanisms underlying organ hyperactivity and pain in a model of cystitis caused by adenoviral-mediated expression of claudin-2 (Cldn2), a tight junction protein that forms paracellular pores and increases urothelial permeability. Read More

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http://dx.doi.org/10.1038/s41598-019-41971-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445132PMC
April 2019
1 Read

Biomarkers implicated in lower urinary tract symptoms: systematic review and pathway analyses.

J Urol 2019 Mar 29:101097JU0000000000000257. Epub 2019 Mar 29.

National Institute of Diabetes and Digestive and Kidney Diseases , Bethesda , MD.

Purpose: Lower urinary tract symptoms (LUTS) are prevalent and burdensome, yet methods to enhance diagnosis and appropriately guide therapies are lacking. We systematically reviewed the literature for human studies of biomarkers associated with LUTS.

Materials And Methods: PUBMED, EMBASE, and Web of Science were searched from inception to February 13, 2018. Read More

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http://dx.doi.org/10.1097/JU.0000000000000257DOI Listing
March 2019
1 Read

Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Diagnostic Tool in the Assessment of Tumour Angiogenesis in Urinary Bladder Cancer.

Can Assoc Radiol J 2019 Mar 25. Epub 2019 Mar 25.

Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia Governorate, Egypt.

Purpose: The aim of study is to assess the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and correlation with tumour angiogenesis in evaluation of urinary bladder cancer.

Material And Methods: The study included 81 patients with recent presumed diagnosis of bladder tumour or who came for follow up after management of histopathologically proven bladder cancer. All had DCE-MRI with time-signal intensity curve. Read More

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http://dx.doi.org/10.1016/j.carj.2018.11.004DOI Listing
March 2019
2 Reads
0.584 Impact Factor

[Diagnosis and treatment of eosinophilic cystitis].

Pan Afr Med J 2018 20;31:45. Epub 2018 Sep 20.

Service d'Urologie, Hôpital Charles Nicole, Tunis, Tunisie.

Eosinophilic cystitis is an inflammatory disease of the bladder wall. It is rare, so there are no standard treatment guidelines. We conducted a retrospective study of 10 patients with eosinophilic cystitis diagnosed and treated in our Department between 2006 and 2017. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.45.16149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430843PMC
April 2019
2 Reads

A Culture-Independent Analysis of the Microbiota of Female Interstitial Cystitis/Bladder Pain Syndrome Participants in the MAPP Research Network.

J Clin Med 2019 Mar 26;8(3). Epub 2019 Mar 26.

c/o Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

We surveyed urine microbiota of females diagnosed with interstitial cystitis/bladder pain syndrome (IC/BPS) and matched control participants enrolled in the National Institutes of Health (NIH) Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network using the culture-independent methodology. Midstream urine specimens were analyzed with the Plex-ID molecular diagnostic platform that utilizes polymerase chain reaction⁻electrospray ionization⁻time-of-flight⁻mass spectrometry (PCR-ESI-TOF MS) to provide a comprehensive identification of bacterial and select fungal species. IC/BPS and control participants were evaluated for differences (presence, diversity, and abundance) in species and genus. Read More

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http://dx.doi.org/10.3390/jcm8030415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462969PMC
March 2019
1 Read

Clustering of Patients with Interstitial Cystitis/Bladder Pain Syndrome and Chronic Prostatitis/Chronic Pelvic Pain Syndrome.

J Urol 2019 Mar 27:101097JU0000000000000250. Epub 2019 Mar 27.

Division of Urologic Surgery, Department of Surgery , and.

Aims: To use clustering analysis of patient symptoms to discover common patient subtypes in females and males with interstitial cystitis/bladder pain syndrome (IC/BPS) or chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Methods: Clinical variables included in the k-means clustering included the severity of urologic pain (0-10 numeric rating scale, NRS), urinary urgency (0-10 NRS), frequency (0-10 NRS), non-urologic pain (0-10 NRS), and either a yes or no to each of the six UPOINT domains.

Results: 211 UCPPS patients seeking care of their IC/BPS or CP/CPPS were included. Read More

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http://dx.doi.org/10.1097/JU.0000000000000250DOI Listing
March 2019
1 Read

Emphysematous cystitis in an elderly Japanese patient with type 2 diabetes mellitus.

Clin Case Rep 2019 Mar 6;7(3):585-586. Epub 2019 Feb 6.

Department of Medicine, Division of Diabetes, Metabolism and Endocrinology Showa University School of Medicine Tokyo Japan.

We report a rare but fatal case of emphysematous cystitis (EC) that presented as a typical image of gas bubbles within the urinary bladder wall on computed tomography (CT). This disease has a high mortality rate more than that reported previously based on recent literature review in Japan. Read More

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http://dx.doi.org/10.1002/ccr3.2028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406141PMC

Uroprotective effect of ambroxol in cyclophosphamide-induced cystitis in mice.

Int Urol Nephrol 2019 Mar 20. Epub 2019 Mar 20.

Faculty of Medicine, Department of Pharmacology, Karadeniz Technical University, 61080, Trabzon, Turkey.

Purpose: Hemorrhagic cystitis (HC) is defined as any types of acute or chronic inflammation of urinary bladder with several reasons. One of the most common causes of HC is cyclophosphamide (CYP), an effective antineoplastic agent, due to its urotoxic potential. Ambroxol (AMB) is a mucoactive drug that has been used for numerous respiratory diseases. Read More

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http://dx.doi.org/10.1007/s11255-019-02128-yDOI Listing
March 2019
2 Reads

Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa.

Clin Infect Dis 2019 Mar 21. Epub 2019 Mar 21.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

Asymptomatic bacteriuria (ASB) is a common finding in many populations, including healthy women and persons with underlying urologic abnormalities. The 2005 guideline from the Infectious Diseases Society of America recommended that ASB should be screened for and treated only in pregnant women or in an individual prior to undergoing invasive urologic procedures. Treatment was not recommended for healthy women; older women or men; or persons with diabetes, indwelling catheters, or spinal cord injury. Read More

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http://dx.doi.org/10.1093/cid/ciy1121DOI Listing
March 2019
4 Reads

Combination of Intravesical Bacille Calmette-Guérin and Chemotherapy vs. Bacille Calmette-Guérin Alone in Non-muscle Invasive Bladder Cancer: A Meta-Analysis.

Front Oncol 2019 1;9:121. Epub 2019 Mar 1.

Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.

About 75% of newly diagnosed bladder cancer cases suffer from non-muscle invasive bladder cancer (NMIBC), which used to recur and progress despite transurethral resection of bladder tumor (TURBT). This meta-analysis was conducted to examine if combined application of intravesical bacille Calmette-Guérin (BCG) with chemotherapy is associated with better prognosis. Systematic searches of randomized controlled trials (RCTs) concerning NMIBC were performed in PubMed, EMbase, CENTRAL, CNKI, WanFang, VIP, CBM databases, and some specialized websites. Read More

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http://dx.doi.org/10.3389/fonc.2019.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405446PMC

The effect of Hydrodistension in combination with Pentosan Polysulfate on treatment outcomes and compliance in the treatment of bladder pain syndrome.

Pak J Med Sci 2019 Jan-Feb;35(1):189-194

Dr. Ceyhun Ozyurt, Department of Urology, Ege University School of Medicine Izmir, Turkey.

Objective: In the present study, we investigated the efficacy of bladder hydrodistension combined with pentosan polysulfate (PPS) treatment in interstitial cystitis (IC)/bladder pain syndrome (BPS).

Methods: In this study, 339 patients diagnosed with IC/BPS were categorized into two groups. The first group only received 300 mg/day PPS, while the second group received 300 mg/day PPS following bladder hydrodistension. Read More

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http://dx.doi.org/10.12669/pjms.35.1.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408654PMC

The short-term efficacy of intravesical instillation of hyaluronic acid treatment for bladder pain syndrome/interstitial cystitis.

Turk J Urol 2018 Dec 20;45(2):129-134. Epub 2018 Dec 20.

Department of Urology, Mersin City Hospital, Mersin, Turkey.

Objective: The aim of the study was to evaluate the short term efficacy of intravesical instillation of hyaluronic acid in patients with Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC).

Material And Methods: The study included 54 women with BPS/IC who received intravesical instillation of hyaluronic acid treatment (120 mg/50 mL) for 6 weeks. Visual Analogue Scale (VAS), The O'Leary Sant Questionnaire (ICSI/ICPI) forms of the patients were filled by the clinician and the health technician separately before and 3 months after the treatment. Read More

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http://dx.doi.org/10.5152/tud.2018.35920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368032PMC
December 2018
1 Read

Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice.

Support Care Cancer 2019 Mar 14. Epub 2019 Mar 14.

Department of Biochemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey.

Purpose: The aim of the present study was to evaluate the potential uroprotective effect of pantoprazole (PPZ) in a mouse model of cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) due to its antioxidant and anti-inflammatory properties.

Methods: Balb/c mice received a single intraperitoneal (i.p. Read More

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http://dx.doi.org/10.1007/s00520-019-04731-2DOI Listing
March 2019
2 Reads

Sacral neuromodulation treating chronic pelvic pain: a meta-analysis and systematic review of the literature.

Int Urogynecol J 2019 Mar 14. Epub 2019 Mar 14.

Division of Female Pelvic Medicine and Reconstructive Surgery, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Mailstop MAC 5034, Cleveland, OH, 44106, USA.

Introduction And Hypothesis: Sacral neuromodulation (SNM) is gaining popularity as a treatment option for chronic pelvic pain (CPP). Our hypothesis is that SNM is effective in improving CPP.

Methods: A systematic search was conducted through September 2018. Read More

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http://link.springer.com/10.1007/s00192-019-03898-w
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http://dx.doi.org/10.1007/s00192-019-03898-wDOI Listing
March 2019
4 Reads
1.961 Impact Factor

A systematic review of preventive and therapeutic options for symptoms of cystitis in patients with bladder cancer receiving intravesical bacillus Calmette-Guérin immunotherapy.

Anticancer Drugs 2019 Jun;30(5):517-522

Department of General, Oncological and Functional Urology, Medical University of Warsaw.

Local adverse effects are the most common clinical issues in patients with bladder cancer receiving intravesical BCG immunotherapy. The aim of this systematic review was to present available options for prevention and treatment of cystitis symptoms related to bacillus Calmette-Guérin (BCG) intravesical instillations. A literature search within the Medline database was conducted in June 2018 with the following search terms: adverse events, Bacillus Calmette-Guerin, BCG, bladder cancer, cystitis, dose, dwell time, dysuria, frequency, intravesical instillations, haematuria, pain, side effects, toxicity and urgency. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000775DOI Listing

Intravesical administration of blebbistatin prevents cyclophosphamide-induced toxicity of the urinary bladder in female Wistar rats.

Neurourol Urodyn 2019 Apr 14;38(4):1044-1052. Epub 2019 Mar 14.

Chair and Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.

Aims: The main goal of our study was to investigate whether blebbistatin would prevent the cyclophosphamide (CYP)-induced changes in cystometric and inflammatory parameters indicating the development of bladder inflammation and bladder overactivity. As the nature of CYP-induced urotoxicity is inflammatory, we assume that agents presenting an anti-inflammatory potential, such as blebbistatin, are worth special attention.

Materials And Methods: The experiments were carried out in female Wistar rats. Read More

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http://dx.doi.org/10.1002/nau.23973DOI Listing
April 2019
2 Reads

Primary Vesical Amyloidosis Masquerading as Vesical Calculus in a Retroviral Positive Patient.

Cureus 2019 Jan 4;11(1):e3828. Epub 2019 Jan 4.

Radiology, Sri Lakshmi Narayana Institute of Medical Science, Puducherry, IND.

The common causes of irritative voiding symptoms in women include cystitis, vesical calculi, carcinoma bladder and neurologic disorders. Isolated primary vesical amyloidosis (VA) is a rare cause of irritative voiding symptoms. A 50-year-old female, a known case of retroviral disease but not on anti-retroviral therapy, presented with right flank and suprapubic pain for six months, worsening over the past 15 days with dysuria. Read More

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http://dx.doi.org/10.7759/cureus.3828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402869PMC
January 2019
3 Reads

Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies.

J Urol 2019 Mar 13:101097JU0000000000000234. Epub 2019 Mar 13.

Japanese Red Cross Medical Center , Tokyo , Japan.

Purpose: Systematic characterization of gene expression, inflammation, and neovascularization in interstitial cystitis/bladder pain syndrome was performed to obtain biological evidence supporting diagnosis and classification.

Materials And Methods: RNA obtained from bladder mucosal biopsies from 33 patients with interstitial cystitis/bladder pain syndrome (three subtypes: 12 with Hunner lesions, 11 without Hunner lesions but with glomerulations, and ten with neither Hunner lesions nor glomerulations) and nine controls was sequenced. Differentially expressed genes for each subtype were searched to identify subtype-specific biological pathways and candidate genes important for pathogenesis. Read More

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http://dx.doi.org/10.1097/JU.0000000000000234DOI Listing

Blocking αδ-1 Subunit Reduces Bladder Hypersensitivity and Inflammation in a Cystitis Mouse Model by Decreasing NF-kB Pathway Activation.

Front Pharmacol 2019 26;10:133. Epub 2019 Feb 26.

NEURO-DOL, Université Clermont Auvergne, Clermont-Ferrand, France.

Bladder pain is frequently associated with bladder inflammation, as in conditions like interstitial cystitis (IC), for which current analgesic therapies have limited efficacy. The antinociceptive effect of alpha-2-delta (αδ) ligands on inflammation-associated visceral pain like that experienced in cystitis has been poorly investigated. To investigate the effect of pregabalin (PGB), an αδ ligand, we evaluated its impact on mechanical hyperalgesia in a mouse model of cystitis induced by cyclophosphamide (CYP). Read More

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http://dx.doi.org/10.3389/fphar.2019.00133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399165PMC
February 2019

Efficacy of pentosan polysulfate for the treatment of interstitial cystitis/bladder pain syndrome: results of a systematic review of randomized controlled trials.

Curr Med Res Opin 2019 Mar 8:1-9. Epub 2019 Mar 8.

e bene pharmaChem GmbH & Co.KG , Geretsried , Germany.

Background: Among the numerous therapeutic approaches used in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) few have been assessed with a sufficient level of evidence. The safety and efficacy of pentosan polysulfate sodium (PPS) has been shown in several open-label and comparative clinical trials with different populations including two meta-analyses. In the context of the approval procedure of PPS for the treatment of IC/BPS by the European Medicines Agency we updated the findings of the previous analyses by incorporating the results of the latest studies. Read More

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http://dx.doi.org/10.1080/03007995.2019.1586401DOI Listing

IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis.

Am J Physiol Renal Physiol 2019 Feb 20. Epub 2019 Feb 20.

Children's National Medical Center, United States.

Chemotherapy-induced hemorrhagic cystitis is characterized by bladder pain and voiding dysfunction caused by hemorrhage and inflammation. Novel therapeutic options to treat hemorrhagic cystitis are needed. We previously reported that systemic administration of the Schistosomiasis haematobium-derived protein H-IPSE (IL-4-inducing principle from Schistosoma mansoni eggs), is superior to 3 doses of MESNA in alleviating hemorrhagic cystitis. Read More

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http://dx.doi.org/10.1152/ajprenal.00468.2018DOI Listing
February 2019
1 Read

Allyl-isothiocyanate ameliorates the pre-neoplastic changes induced by the fern Dryopteris nigropalaceae on experimental feeding in Guinea pigs.

Res Vet Sci 2019 Feb 16;124:24-31. Epub 2019 Feb 16.

ICAR-Indian Veterinary Research Institute, Regional Station, Palampur 176061, India.

Enzootic bovine haematuria, caused by long-term ingestion of ferns, is a chronic disease of hill cattle characterized by neoplastic lesions in the urinary bladder. Objectives of this study were to investigate the toxicity potential of long-term feeding of the fern Dryopteris nigropalaceae and effect of allyl isothiocyanate (AITC) to ameliorate fern toxicity and the associated pathological changes. The LC-MS analysis of the fern showed presence of ptaquiloside (4. Read More

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http://dx.doi.org/10.1016/j.rvsc.2019.02.003DOI Listing
February 2019
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Integrated Fourier Transform Infrared Imaging and Proteomics for Identification of a Candidate Histochemical Biomarker in Bladder Cancer.

Am J Pathol 2019 Mar 12;189(3):619-631. Epub 2019 Feb 12.

Department of Biophysics, Ruhr University Bochum, Bochum, Germany. Electronic address:

Histopathological differentiation between severe urocystitis with reactive urothelial atypia and carcinoma in situ (CIS) can be difficult, particularly after a treatment that deliberately induces an inflammatory reaction, such as intravesical instillation of Bacillus Calmette-Guèrin. However, precise grading in bladder cancer is critical for therapeutic decision making and thus requires reliable immunohistochemical biomarkers. Herein, an exemplary potential biomarker in bladder cancer was identified by the novel approach of Fourier transform infrared imaging for label-free tissue annotation of tissue thin sections. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183073
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http://dx.doi.org/10.1016/j.ajpath.2018.11.018DOI Listing
March 2019
5 Reads

[The effectiveness of complex phytotherapeutic medications in the management of uncomplicated lower urinary tract infections in women].

Urologiia 2018 Oct(4):10-13

Department of Urology, N.N. Burdenko Voronezh State Medical University, Voronezh, Russia.

Introduction: Lower urinary tract infections (LUTI) are the most common urological diseases. Fosfomycin is one of the antibiotic agents with proven efficacy that are most frequently used to treat UTIs. Despite the high effectiveness of antibiotic therapy with this drug, in some patients, the LUTIs persist or recur. Read More

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October 2018

[Efficiency of fosfomycin trometamol for treatment of acute uncomplicated cystitis].

Urologiia 2018 Dec(6):70-75

Department of Urology of FGBOU VO Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia.

Introduction: Acute cystitis is the most common type of uncomplicated urinary tract infection. A choice of antibiotics for the treatment depends not only on the spectrum of antimicrobial activity against pathogens, but also on the pharmacokinetic properties, due to high urine concentration after single or double use is needed. In addition, high safety profile and acceptable cost are important. Read More

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December 2018

Sex steroid hormone receptors in bladder cancer: Usefulness in differential diagnosis and implications in histogenesis of bladder cancer.

Urol Oncol 2019 Feb 6. Epub 2019 Feb 6.

Department of Urology, Dokkyo Medical University, Tochigi, Japan.

Objective: In rare cases, differential diagnosis between bladder cancer (BC) and gynecological tract cancer (GTC) is difficult because of anatomical proximity and morphological similarity. We analyzed expression status of sex steroid hormone receptors in BC in this study. First, we investigated their usefulness as a histological marker for differential diagnosis. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.023DOI Listing
February 2019
5 Reads

Chronic Lower Urinary Tract Signs in Cats: Current Understanding of Pathophysiology and Management.

Vet Clin North Am Small Anim Pract 2019 Mar;49(2):187-209

Department of Veterinary Medicine and Epidemiology University of California Davis, Davis, CA 95694, USA.

Cats that present with chronic lower urinary tract signs are often diagnosed with feline idiopathic/interstitial cystitis, a disease syndrome that is more than just a bladder disease and can be associated wtih a myriad of other co-morbidities. Further, gaining a better understanding of FIC (including the most accurate descriptive terminology) may help researchers, veterinarians, pet food companies, and clients develop and tailor the best possible approaches to management of these cat's unique health and welfare needs. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.11.001DOI Listing
March 2019
3 Reads

Diagnosis in a Preclinical Model of Bladder Pain Syndrome Using a Au/ZnO Nanorod-based SERS Substrate.

Nanomaterials (Basel) 2019 Feb 7;9(2). Epub 2019 Feb 7.

Biomedical Engineering Research Center, Asan Medical Center, Seoul 05505, Korea.

To evaluate the feasibility of ZnO nanorod-based surface enhanced Raman scattering (SERS) diagnostics for disease models, particularly for interstitial cystitis/bladder pain syndrome (IC/BPS), ZnO-based SERS sensing chips were developed and applied to an animal disease model. ZnO nanorods were grown to form nano-sized porous structures and coated with gold to facilitate size-selective biomarker detection. Raman spectra were acquired on a surface enhanced Raman substrate from the urine in a rat model of IC/BPS and analyzed using a statistical analysis method called principal component analysis (PCA). Read More

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http://www.mdpi.com/2079-4991/9/2/224
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http://dx.doi.org/10.3390/nano9020224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409757PMC
February 2019
9 Reads

IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways.

Sci Rep 2019 Feb 7;9(1):1586. Epub 2019 Feb 7.

Bladder Immunology Group, Biomedical Research Institute, Rockville, MD, USA.

Ifosfamide and other oxazaphosphorines can result in hemorrhagic cystitis, a constellation of complications caused by acrolein metabolites. We previously showed that a single dose of IPSE (Interleukin-4-inducing principle from Schistosoma eggs), a schistosome-derived host modulatory protein, can ameliorate ifosfamide-related cystitis; however, the mechanisms underlying this urotoxicity and its prevention are not fully understood. To provide insights into IPSE's protective mechanism, we undertook transcriptional profiling of bladders from ifosfamide-treated mice, with or without pretreatment with IPSE or IPSE-NLS (a mutant of IPSE lacking nuclear localization sequence). Read More

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http://dx.doi.org/10.1038/s41598-018-38274-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367514PMC
February 2019
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Ketamine‑induced bladder dysfunction is associated with extracellular matrix accumulation and impairment of calcium signaling in a mouse model.

Mol Med Rep 2019 Apr 29;19(4):2716-2728. Epub 2019 Jan 29.

Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi 600, Taiwan, R.O.C.

Due to the rising abuse of ketamine usage in recent years, ketamine‑induced urinary tract syndrome has received increasing attention. The present study aimed to investigate the molecular mechanism underlying ketamine‑associated cystitis in a mouse model. Female C57BL/6 mice were randomly divided into two groups: One group was treated with ketamine (100 mg/kg/day of ketamine for 20 weeks), whereas, the control group was treated with saline solution. Read More

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http://dx.doi.org/10.3892/mmr.2019.9907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423593PMC
April 2019
3 Reads

Iron Chelation as Novel Treatment for Interstitial Cystitis.

Pharmacology 2019 29;103(3-4):159-162. Epub 2019 Jan 29.

Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada,

Interstitial cystitis (IC) is a highly prevalent debilitating disease, with its cardinal symptoms being severe pain, urinary urgency and frequency. The associated pain may eventually lead as a last resort to removal of the bladder. Though the initial trigger for IC remains largely unknown, we propose novel iron chelators as a possible new treatment for this disease. Read More

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http://dx.doi.org/10.1159/000496089DOI Listing
March 2019
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Comparison of Voiding Dysfunction Phenotypes in Women with Interstitial Cystitis/Bladder Pain and Myofascial Pelvic Pain: Results from the ICEPAC Trial.

Urology 2019 Apr 22;126:54-58. Epub 2019 Jan 22.

Department of Neurology, Medical College of Wisconsin, Milwaukee, WI. Electronic address:

Objective: To evaluate whether voiding parameters differ in patients with the common overlapping pelvic pain disorders, interstitial cystitis/bladder pain syndrome (IC/BPS), and myofascial pelvic pain (MPP).

Methods: Uroflow and voiding diary assessed voiding phenotypes in this prospective cohort study (ICEPAC) of women comparing IC/BPS, IC/BPS +MPP, MPP, and healthy control (HC) subjects.

Results: In 36 HC, 24 IC/BPS, 37 IC/BPS + MPP, and 14 MPP subjects, the voiding diary measurements indicate lower voided volumes in IC/BPS and IC/BPS + MPP groups (185 ± 24 mL, 169 ± 20 mL, respectively) compared to HC and MPP groups (294 ± 24 mL, 226 ± 36 mL, respectively; P <. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443427PMC
April 2019
3 Reads

Management of Symptom Flares and Patient-reported Flare Triggers in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)-Findings From One Site of the MAPP Research Network.

Urology 2019 Apr 22;126:24-33. Epub 2019 Jan 22.

Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO.

Objective: To document patient-reported interstitial cystitis/bladder pain syndrome (IC/BPS) flare management strategies and triggers.

Materials And Methods: Twenty-four male and 29 female participants enrolled at the Washington University site of the MAPP Research Network completed a questionnaire on strategies they utilized to manage flares and factors they believed triggered their flares (eg, specific food items, physical activities, sexual activities, infections, and stress). Participants were also asked about the diurnal timing of their flares. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.012DOI Listing
April 2019
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The Remarkable Biomechanical Properties of the Type 1 Chaperone-Usher Pilus: A Structural and Molecular Perspective.

Microbiol Spectr 2019 01;7(1)

Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 7HX, United Kingdom.

Chaperone-usher (CU) pili are long, supramolecular protein fibers tethered to the surface of numerous bacterial pathogens. These virulence factors function primarily in bacterial adhesion to host tissues, but they also mediate biofilm formation. Type 1 and P pili of uropathogenic (UPEC) are the two best-studied CU pilus examples, and here we primarily focus on the former. Read More

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http://dx.doi.org/10.1128/microbiolspec.PSIB-0010-2018DOI Listing
January 2019
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Intravesical Administration of Xenogeneic Porcine Urothelial Cells Attenuates Cyclophosphamide-Induced Cystitis in Mice.

Cell Transplant 2019 Mar 24;28(3):296-305. Epub 2019 Jan 24.

1 Departments of Medical Laboratory Science and Biotechnology and Urology, Sex Hormone Research Center, China Medical University and Hospital, Taichung.

The urothelium of the bladder, renal pelvis, ureter and urethra is maintained through the regulated proliferation and differentiation of urothelial stem and progenitor cells. These cells provide a rich source of a novel urothelial cell therapy approach that could be used to protect, regenerate, repair and restore a damaged urothelium. Urothelial injury caused by physical, chemical and microbial stress is the pathological basis of cystitis (bladder inflammation). Read More

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http://journals.sagepub.com/doi/10.1177/0963689718822773
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http://dx.doi.org/10.1177/0963689718822773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425110PMC
March 2019
8 Reads

Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis.

Ther Adv Urol 2019 Jan-Dec;11:1756287218818030. Epub 2019 Jan 8.

Medical University of Warsaw, Warszawa, Mazowieckie, Poland.

Although it has been proposed that NOD-like receptor protein 3 (NLRP3) inflammasome activation may have an important contribution to the onset of bladder pain syndrome/interstitial cystitis (BPS/IC), as of today there is still insufficient evidence to accept or to reject this hypothesis. However, taking into consideration that inflammasomes have been already shown as important mediators of cyclophosphamide-induced bladder inflammation and that some studies have also revealed human bladder epithelium expresses high levels of NLRP3, such a hypothesis seems to be reasonable. The purpose of this review is to discuss a scenario that NLRP3 inflammasome is a crucial player in the development of this disease. Read More

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http://dx.doi.org/10.1177/1756287218818030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329030PMC
January 2019
2 Reads