195,225 results match your criteria Bladder Cystitis


Bridging the Gap Between the Intensive Care Unit and the Acute Medical Care Unit.

Am J Crit Care 2021 May;30(3):193-200

Liron Sinvani is an associate professor, Division of Hospital Medicine, Department of Medicine, Zucker School of Medicine at Hofstra/Northwell, and an assistant professor, Feinstein Institutes for Medical Research, Northwell Health.

Background: Despite a growing cohort of intensive care unit (ICU) survivors, little is known about the early ICU aftercare period.

Objective: To identify gaps in early ICU aftercare and factors associated with poor hospital outcomes.

Methods: A multisite, retrospective study (January 1 to December 31, 2017) was conducted among randomly selected patients admitted to the medical ICU and subsequently transferred to acute medical care units. Read More

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High-pressure balloon dilatation for the treatment of primary obstructive megaureter: is it the first line of treatment in children and infants?

Swiss Med Wkly 2021 Jun 23;151:w20513. Epub 2021 Jun 23.

Paediatric Urology Unit, "Santobono- Pausilipon" Children's Hospital, Naples, Italy.

Aims Of The Study: To evaluate the efficacy of high-pressure balloon dilatation (HPBD) as treatment of primary obstructive megaureter (POM) in paediatric patients, we analysed the data of our institute from June 2018 to September 2019.

Methods: 14 patients, aged 5 months to 5 years, with POM were treated with HPBD. All patients had a distal ureter dilatation greater than 7 mm associated with obstructive features on a mercaptoacetyl triglycine-3 diuretic renogram scan, and a voiding cystourethrogram without vesicoureteral reflux. Read More

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Cyclophosphamide-induced inflammation of taste buds and cytoprotection by amifostine.

Chem Senses 2021 Jun 23. Epub 2021 Jun 23.

Department of Biology and Vermont Chemosensory Group, University of Vermont, 109 Carrigan Drive, Burlington, Vermont, United States of America.

Taste buds in the oral cavity have a complex immune system regulating normal functions and inflammatory reactions. Cyclophosphamide (CYP), a chemotherapy drug, has wide ranging disruptive effects on the taste system including loss of taste function, taste sensory cells, and capacity for taste cell renewal. In bladder epithelium, CYP also induces inflammation. Read More

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The association between the histopathological features and microsatellite instability in young patients with urothelial carcinoma of the bladder.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):64-70

Dokuz Eylul University, Faculty of Medicine, Department of Pathology - Izmir, Turkey.

Objective: Bladder cancer under the age of 40 is extremely rare. Bladder cancer development involves complex and multi-stage processes, one of which is the DNA damage repair mechanism. In this retrospective study, we aimed to evaluate the histopathological features of bladder urothelial carcinoma seen in patients under 40 years of age and tumor microsatellite instability status using immunohistochemistry. Read More

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January 2021

Transcutaneous electrical nerve stimulation and solifenacin succinate versus solifenacin succinate alone for treatment of overactive bladder syndrome: A double-blind randomized controlled study.

PLoS One 2021 23;16(6):e0253040. Epub 2021 Jun 23.

Department of Urology, The Second Hospital of Shandong University, Jinan, China.

Objective: We evaluated a combination of transcutaneous electrical nerve stimulation (TENS) and solifenacin succinate versus solifenacin alone in the treatment of overactive bladder (OAB).

Methods: Ninety-seven female outpatients with OAB were screened for this double-blind randomized controlled study. Eighty-six patients who met our inclusion criteria were divided randomly into two groups. Read More

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: R-Based Software Toolbox for Untargeted Metabolomics with Bladder Cancer Biomarkers Discovery Case Study.

J Proteome Res 2021 Jun 23. Epub 2021 Jun 23.

Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.

Large-scale untargeted LC-MS-based metabolomic profiling is a valuable source for systems biology and biomarker discovery. Data analysis and processing are major tasks due to the high complexity of generated signals and the presence of unwanted variations. In the present study, we introduce an R-based open-source collection of scripts called (), which provides comprehensive data processing. Read More

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["Treatment of bladder cancer with immune checkpoints inhibitors"].

Rev Prat 2021 Apr;71(4):391-395

Sorbonne Université, GRC n° 5, PREDICTIVE ONCO-UROLOGY, AP-HP, groupe hospitalier La Pitié-Salpêtrière, service d'urologie, Paris, France.

"Treatment of bladder cancer with immune checkpoints inhibitors .Checkpoint inhibitors could lead to a significant improvement in the management of bladder cancer. For metastatic bladder cancer, checkpoint inhibitors showed an improved overall survival and are currently recommended in second intention. Read More

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Perioperative outcomes of transurethral resection for t1 bladder tumors: quality evaluation based on patient, tumor and surgeon criteria.

World J Urol 2021 Jun 23. Epub 2021 Jun 23.

Service D'Urologie, Hôpital Saint Louis, APHP, 1 avenue Claude Vellefaux, 75010, Paris, France.

Introduction: Transurethral resection of bladder tumor (TURBT) is a fundamental but challenging step in the diagnosis and treatment of non-muscle invasive bladder cancer (NMIBC). The first- and second-look TURBT are central in the management of T1 tumors.

Materials And Methods: We retrospectively reviewed all patients treated with TURBT for T1 urothelial cell carcinoma (UCC) of the bladder in one academic institution between 2007 and 2017. Read More

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Insights of fibroblast growth factor receptor 3 aberrations in pan-cancer and their roles in potential clinical treatment.

Aging (Albany NY) 2021 Jun 23;13. Epub 2021 Jun 23.

Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Fibroblast growth factor receptor 3 (FGFR3) alters frequently across various cancer types and is a common therapeutic target in bladder urothelial carcinoma (BLCA) with FGFR3 variants. Although emerging evidence supports the role of FGFR3 in individual cancer types, no pan-cancer analysis is available. In this work, we used the open comprehensive datasets, covering a total of 10,953 patients with 10,967 samples across 32 TCGA cancer types, to identify the full alteration spectrum of FGFR3. Read More

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Metabolic syndrome and bladder cancer.

Authors:
Yair Lotan

BJU Int 2021 Jul;128(1):1-2

Department of Urology, UT Southwestern Medical Center at Dallas, Dallas, TX, USA.

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Dosimetric impact of using a commercial metal artifact reduction tool in carbon ion therapy in patients with hip prostheses.

J Appl Clin Med Phys 2021 Jun 23. Epub 2021 Jun 23.

Shanghai Key Laboratory of Radiation Oncology, Shanghai, China.

The study investigated the dosimetric impact of an iterative metal artifact reduction (iMAR) tool on carbon ion therapy for pelvic cancer patients with hip prostheses. An anthropomorphic pelvic phantom with unilateral and bilateral hip prostheses was used to simulate pelvic cancer patients with metal implants. The raw data obtained from phantom CT scanning were reconstructed with a regular filtered back projection (FBP) algorithm and then corrected with iMAR. Read More

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Investigation of Fiber-Driven Mechanical Behavior of Human and Porcine Bladder Tissue Tested Under Identical Conditions.

J Biomech Eng 2021 Jun 23. Epub 2021 Jun 23.

Mechanical Engineering Department, Michigan State University, 474 S Shaw Ln, East Lansing, MI 48824.

The urinary bladder is a highly dynamic organ, that undergoes large deformations several times a day. Mechanical characteristics of the tissue are crucial in determining the function, and dysfunction, of the organ. Yet, literature reporting on the mechanical properties of human bladder tissue is scarce and, at times, contradictory. Read More

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Robotic assisted reconstruction for complications following urologic oncologic procedures.

Transl Androl Urol 2021 May;10(5):2272-2279

Division of Urology, Department of Surgery, Cooper University Health Care, Cooper Medical School of Rowan University, Camden, NJ, USA.

Despite technical refinements in urologic oncologic surgery, complications are inevitable and often carry significant morbidity. Similar to oncologic surgery, reconstructive surgery has realized a paradigm shift from mainly open to an increasingly minimally invasive approach. Robotic assisted surgery has facilitated this transition as it mitigates some of the limitations of traditional laparoscopy. Read More

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Role of lymph node dissection at the time of open or minimally invasive nephroureterectomy.

Transl Androl Urol 2021 May;10(5):2233-2245

Department of Urology and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Unlike urothelial carcinoma of the bladder, there is no guideline-based consensus on whether a lymph node dissection (LND) should be performed at the time of radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Variable lymphatic drainage based on primary tumor location, lack of prospective trials, and difficulties in developing a risk-adapted approach to LND for UTUC are all challenges to the development of an established approach. The UTUC literature consists of an evidence pool that has historically been limited to single-institution series with heterogenous inclusion criteria for LND and variable LND templates. Read More

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Contemporary techniques and outcomes of robotic assisted radical cystectomy with intracorporeal urinary diversion.

Transl Androl Urol 2021 May;10(5):2216-2232

Department of Urology, NYU Winthrop Hospital, Garden City, NY, USA.

The open approach to radical cystectomy continues to be accompanied by significant morbidity despite enhanced recovery protocols (ERP). Robotic assisted radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD) has become an increasingly popular technique for removal of aggressive bladder cancer and subsequent urinary diversion. Randomized clinical trials comparing the robotic and open techniques address the uncertainty surrounding oncological efficacy of the RARC and show that RARC is at least comparable to open radical cystectomy (ORC) in terms of oncologic adequacy and survival. Read More

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Robotic assisted radical cystectomy versus open radical cystectomy: a review of what we do and don't know.

Transl Androl Urol 2021 May;10(5):2209-2215

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Radical cystectomy (RC) is the gold standard treatment for muscle-invasive and high-risk, noninvasive bladder cancer. Since 2003, robot-assisted radical cystectomy (RARC) has been gaining popularity. Metanalyses show that the primary advantage of RARC is less blood loss and the primary advantage of open radical cystectomy (ORC) is shorter operative times. Read More

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Devazepide suppresses cell proliferation and migration, and induces apoptosis in bladder carcinoma.

Transl Androl Urol 2021 May;10(5):2113-2121

Department of Urology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.

Background: This study aimed to examine the effects of devazepide on the proliferation, migration, and apoptosis of human bladder cancer (BC) 5637 cells, and its mechanism.

Methods: A cell counting kit-8 (CCK-8) for cell viability assays, a colony formation assay, and immunofluorescence were applied to detect the effects of devazepide on the proliferation of 5637 cells. Cell cycle assay, cell apoptosis assay and wound healing assay were performed to detect the effects of devazepide on the cell cycle, apoptosis, and migration of 5637 cells. Read More

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Multicenter urethroplasty outcomes for urethral stricture disease for patients with neurogenic bladder or bladder dysfunction requiring clean intermittent catheterization.

Transl Androl Urol 2021 May;10(5):2035-2042

Department of Urology, Zuckerberg San Francisco General Hospital, University of California-San Francisco, San Francisco, CA, USA.

Background: Our objective is to better comprehend treatment considerations for urethral stricture disease (USD) in patients requiring long-term clean intermittent catheterization (CIC). Patient characteristics, surgical outcomes and complications are unknown in this population.

Methods: Six members of the Trauma and Urologic Reconstruction Network of Surgeons (TURNS) participated in a prospective (2009 to present) and retrospective (prior to 2009) database recording patient demographics, surgical approach and outcomes. Read More

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Botulinum toxin A improves neurogenic bladder fibrosis by suppressing transforming growth factor β1 expression in rats.

Transl Androl Urol 2021 May;10(5):2000-2007

Department of Urology, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.

Background: Intradetrusor botulinum toxin A injection is recommended for the treatment of refractory detrusor overactivity (DO) in patients with neurogenic bladder, however, whether it could inhibit neurogenic bladder fibrosis is uncertain. This study aimed to investigate the effect of botulinum toxin A on neurogenic bladder fibrosis and the underlying mechanism.

Methods: Forty eight Female Wistar rats were evenly randomized into 4 groups: Sham, T10 transection, Early and Late groups. Read More

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Intermediate-term results of a prospective, multicenter study on remote programming sacral neuromodulation for refractory overactive bladder.

Transl Androl Urol 2021 May;10(5):1966-1975

Urology Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing, China.

Background: To evaluate the efficacy and safety of a novel remote programming sacral neuromodulation (SNM) system (BetterStim system) in the treatment of patients with refractory overactive bladder (OAB) for 3 years.

Methods: A total of 8 centers in China enrolled 84 patients with OAB. Following test stimulation 70 patients underwent implantation using BetterStim. Read More

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Construction and analysis of a ceRNA network and patterns of immune infiltration in bladder cancer.

Transl Androl Urol 2021 May;10(5):1939-1955

Department of Urology, The First Hospital of China Medical University, Shenyang, China.

Background: Bladder cancer (BC) is the ninth most common malignant tumor, accounting for an estimate of 549,000 new BC cases and 200,000 BC-related deaths worldwide in 2018. The prognosis of BC has not substantially improved despite significant advances in the diagnosis and treatment of the disease.

Methods: The RNA sequencing (RNA-seq) data and clinical information of BC patients were downloaded from The Cancer Genome Atlas (TCGA) database. Read More

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Acute Liver Failure in Sickle Cell Disease: A Perfect Storm.

Cureus 2021 Jun 16;13(6):e15680. Epub 2021 Jun 16.

Medical Oncology, Sinai Hospital of Baltimore, Baltimore, USA.

Sickle cell hepatopathy is a well-described but uncommonly seen complication of sickle cell disease and is usually caused by multiple overlapping processes. A more acute liver complication is hepatic sequestration which is important to recognize in order to initiate life-saving treatment. A 33-year-old woman with sickle cell disease complicated by painful crises, splenic infarction and significant alcohol abuse presented with gastrointestinal distress, pain crisis, acute-on-chronic anemia, and hyperbilirubinemia in the setting of greater than baseline alcohol consumption. Read More

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Gastrocnemius acrometastasis from muscle-invasive urothelial bladder carcinoma: A case report.

Radiol Case Rep 2021 Aug 9;16(8):2099-2102. Epub 2021 Jun 9.

Department of Radiology, Faculty of Medicine, Hospital Canselor Tunku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Urinary bladder carcinoma is a common malignancy worldwide. The metastatic disease to distant organs including lung, liver, and bone is well established. However, metastasis to below-knee-level; also known as acrometastasis is a rare occurrence and occurs approximately 0. Read More

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Differences in cancer incidence and pattern between urban and rural Nepal: one-year experience from two population-based cancer registries.

Ecancermedicalscience 2021 11;15:1229. Epub 2021 May 11.

Nepal Health Research Council, RamshahPath, Kathmandu 44600, Nepal.

Variations in cancer incidence, mortality and pattern exist in rural and urban areas. Understanding these differences helps in developing targeted cancer prevention and control strategies. However, no previous studies have explored the differences in cancer demographics between the rural and urban areas of Nepal. Read More

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Functional Outcomes of Arteriovenous Fistulas Created by Nephrologist.

Authors:
A Sharma P Thapa

Kathmandu Univ Med J (KUMJ) 2020 Jul-Sept.;18(71):266-270

Department of Surgery, Nepalgunj Medical College and Teaching Hospital, Kohalpur, Banke, Nepal.

Background Preoperative accurate staging of gallbladder cancer is still difficult. A number of patients with gallbladder cancer who undergo laparotomy for curative resection are ultimately found to have unresectable disease. The benifit of staging laparoscopy is its ability to find out the radilogical occult intraperitoneal metastasis and to spare from nontheraputic laparotomy. Read More

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[Evolution of the USP and IPSS score after continuous positive airway pressure sleep apnea therapy at night].

Prog Urol 2021 Jun 19. Epub 2021 Jun 19.

Service d'urologie, clinique Pasteur, 17200 Royan, France.

Introduction: To assess the impact of nocturnal continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea (OSA) on lower urinary tract (LUTS) symptoms.

Materials And Methods: A prospective, monocentric study was conducted between June 2018 and August 2019. Patients with moderate to severe OSA with an indication for treatment with nocturnal CPAP in combination with SBAU were included. Read More

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Macro and microeconomics of blue light cystoscopy with CYSVIEW® in non-muscle invasive bladder cancer.

Urol Oncol 2021 Jun 20. Epub 2021 Jun 20.

Department of Urology, MD Anderson Cancer Center, Houston, TX.

Objective: To determine the estimated budget impact to practices that incorporate blue light cystoscopy (BLC) with hexaminolevulinate HCl (HAL) for the surveillance of non-muscle-invasive bladder cancer (NMIBC) in the clinic setting. With the introduction of advanced technologies in the clinic setting such as HAL, further cost comparative research is needed to justify HAL as a high value option.

Material And Methods: A budget impact model was developed from the facility perspective assessing projected costs at 2 years for a simulated facility with 50 newly diagnosed bladder cancer patients. Read More

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Ultrasonographic 3D Evaluation in the Diagnosis of Bladder Endometriosis: A Prospective Comparative Diagnostic Accuracy Study.

Gynecol Obstet Invest 2021 Jun 22:1-8. Epub 2021 Jun 22.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy.

Objective: The use of three-dimensional (3D) transvaginal ultrasonography (TVS) has been investigated for the diagnosis of deep endometriosis (DE). This study aimed to evaluate if 3D reconstructions improve the performance of TVS) in assessing the presence and characteristics of bladder endometriosis (BE).

Design: This was a single-center comparative diagnostic accuracy study. Read More

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Gene Expression Profiling of Muscle-Invasive Bladder Cancer With Secondary Variant Histology.

Am J Clin Pathol 2021 Jun 22. Epub 2021 Jun 22.

Department of Urology, Erasmus MC, Cancer Institute Rotterdam,  The Netherlands.

Objectives: To determine the potential impact of the presence of secondary variant histology on the gene expression profiles of muscle-invasive bladder cancer (MIBC) tumors.

Methods: For six tumors, revised samples were collected from urothelial and secondary variant components (cohort A). The commercial cohort (cohort B) consisted of the anonymized gene expression profiles of 173 patients with MIBC. Read More

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Trigone as a diagnostic and therapeutic target for bladder-centric interstitial cystitis/bladder pain syndrome.

Int Urogynecol J 2021 Jun 22. Epub 2021 Jun 22.

Rutgers Robert Wood Johnson Medical School, Department of Obstetrics, Gynecology and Reproductive Sciences, 125 Paterson Street, New Brunswick, NJ, 08901, USA.

The pathophysiology of interstitial cystitis/bladder pain syndrome (IC/BPS) may be bladder-centric, with afferent nerve hyperexcitability and/or due to neural central sensitization. In bladder-centric disease, the trigone's unmyelinated nociceptive C-fibers are thought to be upregulated, suggesting this as a potential target for diagnostic modalities and for treatment with local anesthetics and chemodenervation. We propose that the transvaginal trigone treatment (T3) route of administration of such treatments should be considered in women with IC/BPS, as this approach is easier and less invasive than cystoscopy. Read More

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