6,793 results match your criteria Bladder Cystitis


[The effectiveness of complex phytotherapeutic medications in the management of uncomplicated lower urinary tract infections in women].

Urologiia 2018 Oct(4):10-13

Department of Urology, N.N. Burdenko Voronezh State Medical University, Voronezh, Russia.

Introduction: Lower urinary tract infections (LUTI) are the most common urological diseases. Fosfomycin is one of the antibiotic agents with proven efficacy that are most frequently used to treat UTIs. Despite the high effectiveness of antibiotic therapy with this drug, in some patients, the LUTIs persist or recur. Read More

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October 2018

[Efficiency of fosfomycin trometamol for treatment of acute uncomplicated cystitis].

Urologiia 2018 Dec(6):70-75

Department of Urology of FGBOU VO Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia.

Introduction: Acute cystitis is the most common type of uncomplicated urinary tract infection. A choice of antibiotics for the treatment depends not only on the spectrum of antimicrobial activity against pathogens, but also on the pharmacokinetic properties, due to high urine concentration after single or double use is needed. In addition, high safety profile and acceptable cost are important. Read More

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December 2018

Sex steroid hormone receptors in bladder cancer: Usefulness in differential diagnosis and implications in histogenesis of bladder cancer.

Urol Oncol 2019 Feb 6. Epub 2019 Feb 6.

Department of Urology, Dokkyo Medical University, Tochigi, Japan.

Objective: In rare cases, differential diagnosis between bladder cancer (BC) and gynecological tract cancer (GTC) is difficult because of anatomical proximity and morphological similarity. We analyzed expression status of sex steroid hormone receptors in BC in this study. First, we investigated their usefulness as a histological marker for differential diagnosis. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.023DOI Listing
February 2019
1 Read

Chronic Lower Urinary Tract Signs in Cats: Current Understanding of Pathophysiology and Management.

Vet Clin North Am Small Anim Pract 2019 Mar;49(2):187-209

Department of Veterinary Medicine and Epidemiology University of California Davis, Davis, CA 95694, USA.

Cats that present with chronic lower urinary tract signs are often diagnosed with feline idiopathic/interstitial cystitis, a disease syndrome that is more than just a bladder disease and can be associated wtih a myriad of other co-morbidities. Further, gaining a better understanding of FIC (including the most accurate descriptive terminology) may help researchers, veterinarians, pet food companies, and clients develop and tailor the best possible approaches to management of these cat's unique health and welfare needs. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.11.001DOI Listing
March 2019
1 Read

Diagnosis in a Preclinical Model of Bladder Pain Syndrome Using a Au/ZnO Nanorod-based SERS Substrate.

Nanomaterials (Basel) 2019 Feb 7;9(2). Epub 2019 Feb 7.

Biomedical Engineering Research Center, Asan Medical Center, Seoul 05505, Korea.

To evaluate the feasibility of ZnO nanorod-based surface enhanced Raman scattering (SERS) diagnostics for disease models, particularly for interstitial cystitis/bladder pain syndrome (IC/BPS), ZnO-based SERS sensing chips were developed and applied to an animal disease model. ZnO nanorods were grown to form nano-sized porous structures and coated with gold to facilitate size-selective biomarker detection. Raman spectra were acquired on a surface enhanced Raman substrate from the urine in a rat model of IC/BPS and analyzed using a statistical analysis method called principal component analysis (PCA). Read More

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http://www.mdpi.com/2079-4991/9/2/224
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http://dx.doi.org/10.3390/nano9020224DOI Listing
February 2019
2 Reads

IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways.

Sci Rep 2019 Feb 7;9(1):1586. Epub 2019 Feb 7.

Bladder Immunology Group, Biomedical Research Institute, Rockville, MD, USA.

Ifosfamide and other oxazaphosphorines can result in hemorrhagic cystitis, a constellation of complications caused by acrolein metabolites. We previously showed that a single dose of IPSE (Interleukin-4-inducing principle from Schistosoma eggs), a schistosome-derived host modulatory protein, can ameliorate ifosfamide-related cystitis; however, the mechanisms underlying this urotoxicity and its prevention are not fully understood. To provide insights into IPSE's protective mechanism, we undertook transcriptional profiling of bladders from ifosfamide-treated mice, with or without pretreatment with IPSE or IPSE-NLS (a mutant of IPSE lacking nuclear localization sequence). Read More

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http://dx.doi.org/10.1038/s41598-018-38274-zDOI Listing
February 2019

Ketamine‑induced bladder dysfunction is associated with extracellular matrix accumulation and impairment of calcium signaling in a mouse model.

Mol Med Rep 2019 Jan 29. Epub 2019 Jan 29.

Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi 600, Taiwan, R.O.C.

Due to the rising abuse of ketamine usage in recent years, ketamine‑induced urinary tract syndrome has received increasing attention. The present study aimed to investigate the molecular mechanism underlying ketamine‑associated cystitis in a mouse model. Female C57BL/6 mice were randomly divided into two groups: One group was treated with ketamine (100 mg/kg/day of ketamine for 20 weeks), whereas, the control group was treated with saline solution. Read More

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http://dx.doi.org/10.3892/mmr.2019.9907DOI Listing
January 2019

Iron Chelation as Novel Treatment for Interstitial Cystitis.

Pharmacology 2019 Jan 29;103(3-4):159-162. Epub 2019 Jan 29.

Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia,

Interstitial cystitis (IC) is a highly prevalent debilitating disease, with its cardinal symptoms being severe pain, urinary urgency and frequency. The associated pain may eventually lead as a last resort to removal of the bladder. Though the initial trigger for IC remains largely unknown, we propose novel iron chelators as a possible new treatment for this disease. Read More

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http://dx.doi.org/10.1159/000496089DOI Listing
January 2019

Comparison of Voiding Dysfunction Phenotypes in Women with Interstitial Cystitis/Bladder Pain and Myofascial Pelvic Pain: Results from the ICEPAC Trial.

Urology 2019 Jan 22. Epub 2019 Jan 22.

Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:

Objectives: To evaluate whether voiding parameters differ in patients with the common overlapping pelvic pain disorders, interstitial cystitis/bladder pain syndrome (IC/BPS) and myofascial pelvic pain (MPP).

Methods: Uroflow and voiding diary assessed voiding phenotypes in this prospective cohort study (ICEPAC) of women comparing IC/BPS, IC/BPS +MPP, MPP, and healthy control (HC) subjects.

Results: In 36 HC, 24 IC/BPS, 37 IC/BPS+MPP, and 14 MPP subjects, the voiding diary measurements indicate lower voided volumes in IC/BPS and IC/BPS+MPP groups (185±24 mL, 169±20 mL, respectively) compared to HC and MPP groups (294 ±24 mL, 226 ±36 mL, respectively; p<0. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.015DOI Listing
January 2019
2 Reads

Management of symptom flares and patient-reported flare triggers in interstitial cystitis/ bladder pain syndrome (IC/BPS) - Findings from one site of the MAPP Research Network.

Urology 2019 Jan 22. Epub 2019 Jan 22.

Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO.

Objective: To document patient-reported interstitial cystitis/ bladder pain syndrome (IC/BPS) flare management strategies and triggers.

Materials And Methods: 24 male and 29 female participants enrolled at the Washington University site of the MAPP Research Network completed a questionnaire on strategies they utilized to manage flares and factors they believed triggered their flares (e.g. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.012DOI Listing
January 2019
2 Reads

The Remarkable Biomechanical Properties of the Type 1 Chaperone-Usher Pilus: A Structural and Molecular Perspective.

Microbiol Spectr 2019 Jan;7(1)

Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 7HX, United Kingdom.

Chaperone-usher (CU) pili are long, supramolecular protein fibers tethered to the surface of numerous bacterial pathogens. These virulence factors function primarily in bacterial adhesion to host tissues, but they also mediate biofilm formation. Type 1 and P pili of uropathogenic (UPEC) are the two best-studied CU pilus examples, and here we primarily focus on the former. Read More

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http://dx.doi.org/10.1128/microbiolspec.PSIB-0010-2018DOI Listing
January 2019
1 Read

Intravesical Administration of Xenogeneic Porcine Urothelial Cells Attenuates Cyclophosphamide-Induced Cystitis in Mice.

Cell Transplant 2019 Jan 24:963689718822773. Epub 2019 Jan 24.

1 Departments of Medical Laboratory Science and Biotechnology and Urology, Sex Hormone Research Center, China Medical University and Hospital, Taichung.

The urothelium of the bladder, renal pelvis, ureter and urethra is maintained through the regulated proliferation and differentiation of urothelial stem and progenitor cells. These cells provide a rich source of a novel urothelial cell therapy approach that could be used to protect, regenerate, repair and restore a damaged urothelium. Urothelial injury caused by physical, chemical and microbial stress is the pathological basis of cystitis (bladder inflammation). Read More

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http://journals.sagepub.com/doi/10.1177/0963689718822773
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http://dx.doi.org/10.1177/0963689718822773DOI Listing
January 2019
3 Reads

Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis.

Ther Adv Urol 2019 Jan-Dec;11:1756287218818030. Epub 2019 Jan 8.

Medical University of Warsaw, Warszawa, Mazowieckie, Poland.

Although it has been proposed that NOD-like receptor protein 3 (NLRP3) inflammasome activation may have an important contribution to the onset of bladder pain syndrome/interstitial cystitis (BPS/IC), as of today there is still insufficient evidence to accept or to reject this hypothesis. However, taking into consideration that inflammasomes have been already shown as important mediators of cyclophosphamide-induced bladder inflammation and that some studies have also revealed human bladder epithelium expresses high levels of NLRP3, such a hypothesis seems to be reasonable. The purpose of this review is to discuss a scenario that NLRP3 inflammasome is a crucial player in the development of this disease. Read More

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http://dx.doi.org/10.1177/1756287218818030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329030PMC
January 2019
1 Read

Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection.

Sci Rep 2019 Jan 14;9(1):106. Epub 2019 Jan 14.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Calcineurin inhibitor Tacrolimus, is a potent immunosuppressive drug widely used in order to prevent acute graft rejection. Urinary tract infection (UTI) is the most frequent infectious complication in renal transplant patients and long-term use of Tacrolimus might be involved in higher susceptibility to bacterial infections. It remains largely unknown how Tacrolimus affects the host innate immune response against lower and upper UTI. Read More

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http://dx.doi.org/10.1038/s41598-018-37482-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331640PMC
January 2019
1 Read

Radical radiotherapy in older patients with muscle invasive bladder cancer.

J Geriatr Oncol 2019 Jan 8. Epub 2019 Jan 8.

Department of Radiation Oncology, National University Cancer Institute, Singapore.

Background: Muscle invasive bladder cancer (MIBC) is prevalent in the older patients, who are a vulnerable population with multiple co-morbidities and at increased risk of complications. Radical cystectomy is often not suitable, hence radical radiotherapy (RT) is an alternative option. We reviewed the outcomes of older patients treated with RT with or without concurrent chemotherapy (CRT) at our institution. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18794068183030
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http://dx.doi.org/10.1016/j.jgo.2018.10.015DOI Listing
January 2019
4 Reads
1.146 Impact Factor

Lower Urinary Tract Symptoms in a Chronic Pelvic Pain Population.

Female Pelvic Med Reconstr Surg 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics and Gynecology, Michigan Medicine, Ann Arbor, MI.

Objectives: This study aimed to characterize the prevalence of lower urinary tract symptoms in a chronic pain population.

Methods: In this observational cohort study, patients referred to a female pelvic pain clinic completed several validated questionnaires assessing bladder symptoms, central sensitization, pain symptoms, depression, anxiety, and neuropathic pain. Patients diagnosed as having interstitial cystitis were excluded. Read More

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http://dx.doi.org/10.1097/SPV.0000000000000689DOI Listing
January 2019
5 Reads

Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Painful Bladder Syndrome.

Front Neurosci 2018 12;12:931. Epub 2018 Dec 12.

Visceral Pain Research Group, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

The bladder is innervated by extrinsic afferents that project into the dorsal horn of the spinal cord, providing sensory input to the micturition centers within the central nervous system. Under normal conditions, the continuous activation of these neurons during bladder distension goes mostly unnoticed. However, for patients with chronic urological disorders such as overactive bladder syndrome (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS), exaggerated bladder sensation and altered bladder function are common debilitating symptoms. Read More

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http://dx.doi.org/10.3389/fnins.2018.00931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299241PMC
December 2018
1 Read

Long-Term Relief of Painful Bladder Syndrome by High-Intensity, Low-Frequency Repetitive Transcranial Magnetic Stimulation of the Right and Left Dorsolateral Prefrontal Cortices.

Front Neurosci 2018 11;12:925. Epub 2018 Dec 11.

Multidisciplinary Pain, Palliative and Support Care Center, UIC22, PHU2 and EA3826, University Hospital Nantes, Nantes, France.

To show the value of low-frequency repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) to treat bladder pain syndrome (BPS), characterized by suprapubic pain, urgency and increased micturition frequency. A 68-year-old woman with BPS underwent 16 sessions of high-intensity, low-frequency (1 Hz) rTMS of the DLPFC, first on the right hemisphere (one daily session for 5 days, followed by one weekly session for 5 weeks), and then on the left hemisphere (one monthly session for 6 months). At the end of the rTMS protocol, suprapubic pain completely vanished, micturition frequency dramatically decreased (by 60-80%), while fatigue and sleep quality improved (by 57-60%). Read More

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http://dx.doi.org/10.3389/fnins.2018.00925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297551PMC
December 2018

Assessment of HER2 Expression in Canine Urothelial Carcinoma of the Urinary Bladder.

Vet Pathol 2019 Jan 6:300985818817024. Epub 2019 Jan 6.

1 Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Canine urothelial carcinoma (UC) has a poor prognosis and high metastatic rate. Human epidermal growth factor receptor 2 (HER2), a receptor tyrosine kinase involved in cell proliferation and differentiation regulation, has been attracting interest as a therapeutic target molecule for human breast cancer. This study investigated expression of the canine homolog of HER2 (ERBB2) in canine UC, and its association with clinical factors. Read More

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http://dx.doi.org/10.1177/0300985818817024DOI Listing
January 2019
12 Reads

Results of Sacral Neuromodulation Therapy for Urinary Voiding Dysfunction: Five-Year Experience of a Retrospective, Multicenter Study in China.

Neuromodulation 2019 Jan 4. Epub 2019 Jan 4.

Department of Urology, West China Hospital, Sichuan University, Chengdu, P.R. China.

Purpose: This five-year, retrospective, multicenter study evaluated the long-term safety and efficiency of sacral neuromodulation (SNM) in Chinese patients with urinary voiding dysfunction.

Patients And Methods: This is a Chinese national, multicenter, retrospective study that included 247 patients (51.2% female) who received an implantable pulse generator (IPG) (InterStim, Medtronic, Minneapolis, MN, USA) between 2012 and 2016. Read More

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http://dx.doi.org/10.1111/ner.12902DOI Listing
January 2019
1 Read

Molecular pathogenesis of interstitial cystitis/bladder pain syndrome based on gene expression.

J Cell Physiol 2019 Jan 4. Epub 2019 Jan 4.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic bladder inflammation that leads to chronic bladder pain and urinary urgency and frequency. The presentation of IC/PBS is heterogeneous, and it is classified as ulcerative IC/PBS and nonulcerative IC/PBS. The main cause of IC/PBS is thought to be a persistent inflammatory condition in the bladder, though the actual pathophysiology has not been identified yet. Read More

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http://doi.wiley.com/10.1002/jcp.28009
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http://dx.doi.org/10.1002/jcp.28009DOI Listing
January 2019
11 Reads

A wireless closed-loop system for optogenetic peripheral neuromodulation.

Nature 2019 01 2;565(7739):361-365. Epub 2019 Jan 2.

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

The fast-growing field of bioelectronic medicine aims to develop engineered systems that can relieve clinical conditions by stimulating the peripheral nervous system. This type of technology relies largely on electrical stimulation to provide neuromodulation of organ function or pain. One example is sacral nerve stimulation to treat overactive bladder, urinary incontinence and interstitial cystitis (also known as bladder pain syndrome). Read More

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http://www.nature.com/articles/s41586-018-0823-6
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http://dx.doi.org/10.1038/s41586-018-0823-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336505PMC
January 2019
24 Reads

Feline Interstitial Cystitis Enhances Mucosa-Dependent Contractile Responses to Serotonin.

Int Neurourol J 2018 Dec 31;22(4):246-251. Epub 2018 Dec 31.

Division of Renal-Electrolyte, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: To determine whether responses to serotonin are altered in bladder strips from cats diagnosed with a naturally occurring form of bladder pain syndrome/interstitial cystitis termed feline interstitial cystitis (FIC).

Methods: Full thickness bladder strips were isolated from aged matched healthy control cats and cats with clinically verified FIC. Bladder strips were mounted in an organ bath and connected to a tension transducer to record contractile activity. Read More

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http://einj.org/journal/view.php?doi=10.5213/inj.1836276.138
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http://dx.doi.org/10.5213/inj.1836276.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312968PMC
December 2018
3 Reads

GAG replenishment therapy for bladder pain syndrome/interstitial cystitis.

Neurourol Urodyn 2018 Dec 28. Epub 2018 Dec 28.

Female Pelvic Medicine & Reconstructive Surgery Center Catholic University, Catholic University, Rome, Italy.

Aims: To present a rationale for the inclusion of urothelial coating dysfunction in the etipathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC) and the preclinical and clinical evidence in support of glycosaminoglycan (GAG) replenishment therapy in the treatment of BPS/IC, supplemented by the clinical experience of medical experts in the field and patient advocates attending a symposium on GAG replenishment at ESSIC'17, the annual Meeting of the International Society for the Study of Bladder Pain Syndrome, held in Budapest, Hungary in 2017.

Results: The urothelial GAG layer has a primary role in providing a permeability barrier to prevent penetration of urinary toxins and pathogens into the bladder wall. Disruption of the GAG layer contributes to the development of BPS/IC. Read More

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http://doi.wiley.com/10.1002/nau.23900
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http://dx.doi.org/10.1002/nau.23900DOI Listing
December 2018
4 Reads

Intravesical injections of platelet-rich plasma is effective and safe in treatment of interstitial cystitis refractory to conventional treatment-A prospective clinical trial.

Neurourol Urodyn 2018 Dec 21. Epub 2018 Dec 21.

Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.

Aims: Current treatments for interstitial cystitis/bladder pain syndrome (IC/BPS) are usually unsuccessful in achieving long-term bladder pain relief and irritable symptom improvement. This study investigated the clinical efficacy of platelet-rich plasma (PRP) intravesical injections on IC/BPS patients refractory to conventional therapies.

Methods: Forty patients received four monthly intravesical injections of 10 mL PRP extracted from 50 mL of whole blood. Read More

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http://dx.doi.org/10.1002/nau.23898DOI Listing
December 2018
1 Read

Stress-induced autonomic dysregulation of mitochondrial function in the rat urothelium.

Neurourol Urodyn 2018 Dec 21. Epub 2018 Dec 21.

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Aim: Chronic stress exacerbates the symptoms of most pain disorders including interstitial cystitis/bladder pain syndrome (IC/BPS). Abnormalities in urothelial cells (UTC) occur in this debilitating bladder condition. The sequence of events that might link stress (presumably through increased sympathetic nervous system-SNS activity) to urothelial dysfunction are unknown. Read More

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http://dx.doi.org/10.1002/nau.23876DOI Listing
December 2018
8 Reads

Interstitial Cystitis/Bladder Pain Syndrome.

Semin Reprod Med 2018 Mar 19;36(2):123-135. Epub 2018 Dec 19.

Department of Obstetrics and Gynecology, Pritzker School of Medicine, University of Chicago, Evanston, Illinois.

Interstitial cystitis/bladder pain syndrome is an uncommon but potentially devastating pelvic pain disorder affecting both women and men. This condition is often confusable and comorbid with other pelvic pain disorders. Although our understanding of the underlying pathophysiology is growing, the exact longitudinal course by which peripheral and central aberrations involving the bladder mucosa, peripheral inflammation, and central dysregulation of bladder sensitivity create painful bladder symptoms remains an area in need of further study. Read More

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http://dx.doi.org/10.1055/s-0038-1676089DOI Listing
March 2018
6 Reads

Cross-over data supporting long-term antibiotic treatment in patients with painful lower urinary tract symptoms, pyuria and negative urinalysis.

Int Urogynecol J 2018 Dec 18. Epub 2018 Dec 18.

Centre for Nephrology, Division of Medicine, University College London, London, UK.

Purpose: To measure the effects of an unplanned, sudden cessation of treatment in an unselected group of patients with chronic painful LUTS managed with protracted antimicrobial treatment and to report these observational data collected from a cross-over process.

Materials And Methods: The imposition of a guideline resulted in the immediate cessation of antibiotic treatment in a cohort of patients with chronic painful LUTS and microscopic pyuria. Patients were assessed before treatment withdrawal, whilst off treatment, and following reinstatement. Read More

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http://dx.doi.org/10.1007/s00192-018-3846-5DOI Listing
December 2018
4 Reads

Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.

Nat Rev Urol 2018 Dec 18. Epub 2018 Dec 18.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA.

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. Read More

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http://www.nature.com/articles/s41585-018-0135-5
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http://dx.doi.org/10.1038/s41585-018-0135-5DOI Listing
December 2018
11 Reads

Eosinophilic cystitis treated with hydrodistention and complementary methods: Case report.

Arch Esp Urol 2018 Dec;71(10):859-862

Clinica de Urología Avanzada UROZEN. Lima. Perú.

Objective: Even though there is no established standard therapy for Eosinophilic cystitis (EC), the series of cases guide us in the treatment of patients. We report our therapeutic experience with hydrodistention and complementary methods. In order to establish a standard treatment in patients with EC. Read More

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December 2018
7 Reads

Superselective vesical artery embolization in the management of intractable hematuria secondary to hemorrhagic cystitis.

World J Urol 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiology, University of Texas Medical Branch, Galveston, TX, 77555-0709, USA.

Purpose: To evaluate the efficacy and outcome of superselective vesical arterial embolization in the management of severe intractable hematuria secondary to hemorrhagic cystitis.

Materials And Methods: We retrospectively reviewed the medical records of nine patients with severe intractable hematuria treated with superselective vesical artery embolization at our institution between March 2003 and February 2015. There were six males and three females with a mean age of 56. Read More

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http://dx.doi.org/10.1007/s00345-018-2604-0DOI Listing
December 2018
3 Reads
2.666 Impact Factor

Longitudinal intravital imaging of transplanted mesenchymal stem cells elucidates their functional integration and therapeutic potency in an animal model of interstitial cystitis/bladder pain syndrome.

Theranostics 2018 9;8(20):5610-5624. Epub 2018 Nov 9.

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Mesenchymal stem cell (MSC) therapy may be a novel approach to improve interstitial cystitis/bladder pain syndrome (IC/BPS), an intractable disease characterized by severe pelvic pain and urinary frequency. Unfortunately, the properties of transplanted stem cells have not been directly analyzed , which hampers elucidation of the therapeutic mechanisms of these cells and optimization of transplantation protocols. Here, we monitored the behaviors of multipotent stem cells (M-MSCs) derived from human embryonic stem cells (hESCs) in real time using a novel combination of confocal endoscopic and microscopic imaging and demonstrated their improved therapeutic potency in a chronic IC/BPS animal model. Read More

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http://dx.doi.org/10.7150/thno.27559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276303PMC
November 2018
2 Reads

Efficacy and Safety of Noninvasive Intravesical Instillation of Onabotulinum Toxin-A for Overactive Bladder and Interstitial Cystitis/Bladder Pain Syndrome: Systematic Review and Meta-analysis.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Soonchunhyang University Seoul Hospital, Soonchunhyang University Medical College, Seoul, South Korea. Electronic address:

Objective: To investigate the efficacy and safety of noninvasive intravesical instillation of onabotulinum toxin-A (OBTX-A) through systematic review and meta-analysis. Recently, several studies of noninvasive intravesical instillation of OBTX-A have been published. However, its efficacy is not well validated yet compared to well-known efficacy of minimally invasive intravesical injection of OBTX-A. Read More

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http://dx.doi.org/10.1016/j.urology.2018.11.037DOI Listing
December 2018
3 Reads
2.188 Impact Factor

Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP receptor antagonist.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Various studies have confirmed that prostaglandins (PG) alter the bladder motor activity and micturition reflex in both human and animals. However, no sufficient data is reported about the effect of cyclooxygenase (COX) inhibitors neither in normal bladder physiology nor in pathological conditions. This study aims to compare the potential effects of some COX inhibitors with varying COX-1/COX-2 selectivities (indomethacin, ketoprofen, and diclofenac) with that of the selective COX-2 inhibitor (DFU) on bladder function. Read More

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http://dx.doi.org/10.1007/s00210-018-01599-7DOI Listing
December 2018
3 Reads

[A Case of Refractory Hemorrhagic Cystitis in which Bleeding Control was Finally Achieved by Cystectomy].

Hinyokika Kiyo 2018 10;64(10):415-418

Hakodate Goryokaku Hospital.

A 60-year-old man presented at our hospital with gross hematuria. He had been treated for nephrotic syndrome with cyclophosphamide and steroids since he was in his 20s. We detected diffuse hemorrhagic cystitis on cystoscopy and diagnosed him with cyclophosphamide-induced hemorrhagic cystitis. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_10_415DOI Listing
October 2018
1 Read

Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner.

PLoS Pathog 2018 12 13;14(12):e1007457. Epub 2018 Dec 13.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Urinary tract infections (UTI) are extremely common and can be highly recurrent, with 1-2% of women suffering from six or more recurrent episodes per year. The high incidence of recurrent UTI, including recurrent infections caused by the same bacterial strain that caused the first infection, suggests that at least some women do not mount a protective adaptive immune response to UTI. Here we observed in a mouse model of cystitis (bladder infection) that infection with two different clinical uropathogenic Escherichia coli (UPEC) isolates, UTI89 or CFT073, resulted in different kinetics of bacterial clearance and different susceptibility to same-strain recurrent infection. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007457
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http://dx.doi.org/10.1371/journal.ppat.1007457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292575PMC
December 2018
2 Reads

[Diagnostic value of the BRAF variant V595E in urine samples, smears and biopsies from canine transitional cell carcinoma].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):289-295. Epub 2018 Dec 12.

Objective: Transitional cell carcinoma (TCC) is the most common malignant tumour of the canine urinary tract. Previously, the mutation of the BRAF gene V595E was identified in approximately 85 % of canine TCC cases by DNA sequencing of TCC tumour cells, both in frozen and paraffin-embedded tissue sections, as well as in urine. The objective of this study was to establish these methods in cytological smears and to investigate the prevalence of BRAF mutation V595E in canine TCC in our cohort of patients. Read More

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http://www.thieme-connect.de/DOI/DOI?10.15654/TPK-180554
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http://dx.doi.org/10.15654/TPK-180554DOI Listing
October 2018
10 Reads

Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria.

Res Rep Urol 2018 16;10:219-225. Epub 2018 Nov 16.

Department of Surgery, Division of Urology, Duke University Medical Center, Durham, NC, USA,

Purpose: Diabetes is a grave and progressive condition characterized by debilitating complications. Diabetic bladder dysfunction (DBD) is a very common complication with no specific treatments currently available. Unlike other tissues affected by this disease, the bladder is subjected to two independent insults; 1) polyuria, created by the osmotic effects of glucose in the urine, and 2) hyperglycemia itself. Read More

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http://dx.doi.org/10.2147/RRU.S177633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247963PMC
November 2018
1 Read

Clinical, histopathologic, cystoscopic, and fluorescence in situ hybridization analysis of proliferative urethritis in 22 dogs.

J Vet Intern Med 2019 Jan 5;33(1):184-191. Epub 2018 Dec 5.

Department of Medicine and Epidemiology, Veterinary Medical Teaching Hospital, University of California-Davis School of Veterinary Medicine, California.

Background: Proliferative urethritis (PU) is a lower urinary tract disease of dogs characterized by frond-like lesions in the urethra. The etiology of PU is unknown, although an association with bacterial cystitis is reported.

Objectives: Deep-seated bacterial cystitis is associated with PU, particularly in dogs with neutrophilic or granulomatous inflammation. Read More

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http://dx.doi.org/10.1111/jvim.15349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335574PMC
January 2019
2 Reads

Keratinizing squamous metaplasia of the bladder: Our experience and current approaches.

Urologia 2018 Dec 3:391560318810197. Epub 2018 Dec 3.

2 Pathology Unit, ASST-Rhodense, Milan, Italy.

Introduction:: Bladder mucosa is anatomically covered by urothelial epithelium. The replacement of the urothelium with stratified squamous cells is defined as squamous metaplasia which can be keratinizing or non-keratinizing. Clinically, it is also known as leukoplakia or keratinizing cystitis of the bladder. Read More

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http://dx.doi.org/10.1177/0391560318810197DOI Listing
December 2018
2 Reads

The effect of herpes simplex virus vector-mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception.

Neurourol Urodyn 2018 Nov 29. Epub 2018 Nov 29.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Aims: We studied the effect of herpes simplex virus (HSV) vectors-based gene transfer of protein phosphatase 1α (PP1α) on bladder hypersensitivity in rats.

Methods: Using adult female Sprague-Dawley rats, non-replicating HSV vectors carrying PP1α or green fluorescent protein (GFP) were injected into the bladder wall. At one week after vector inoculation, cystometry and Western blot assay were performed, whereas the other experiments were performed at 2 weeks after vector inoculation. Read More

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http://dx.doi.org/10.1002/nau.23882DOI Listing
November 2018
2 Reads

Sexual and bladder dysfunction in male ketamine abusers: A large-scale questionnaire study.

PLoS One 2018 28;13(11):e0207927. Epub 2018 Nov 28.

Department of Urology, Taipei Tzu Chi Hospital, New Taipei, Taiwan.

Purpose: To evaluate the prevalence of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) in the illicit male ketamine abusers (KA).

Materials And Methods: The male street KAs caught by policemen and patients visiting urologic clinics were invited to answer a structured questionnaire including demographic data, illicit drug use related details (duration, frequency, dosage and abstinence status), international prostate symptoms score (IPSS), interstitial cystitis symptoms and problem index (ICSI and ICPI) and International index of erectile function (IIEF-5). Erectile dysfunction was defined as IIEF-5 ≦21. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207927PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261603PMC
November 2018
1 Read

Emphysematous Cystitis.

J Belg Soc Radiol 2018 Oct 12;102(1):66. Epub 2018 Oct 12.

Sint-Andriesziekenhuis, Tielt, BE.

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http://dx.doi.org/10.5334/jbsr.1192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196580PMC
October 2018
2 Reads

Extracorporeal shockwave against inflammation mediated by GPR120 receptor in cyclophosphamide-induced rat cystitis model.

Mol Med 2018 11 27;24(1):60. Epub 2018 Nov 27.

Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan.

Background: We tested the hypothesis that extracorporeal shockwave treatment (ESWT) can abolish inflammation and restore urothelial barrier integrity in acute interstitial cystitis by upregulating the fatty acid receptor GPR120.

Methods: A total of 30 female Sprague-Dawley rats were categorized into five groups: (1) sham-operated rats (SC); (2) rats treated with ESWT (SC + ESWT); (3) rats with bladder irritation using 150 mg/kg cyclophosphamide through intraperitoneal injection; (4) cyclophosphamide rats treated with ESWT (cyclophosphamide+ESWT); (5) cyclophosphamide rats treated with GPR120 agonist (cyclophosphamide+GW9508).

Results: On Day 3, urine and bladder specimens were collected for biochemical, histopathological, immunological, and immunoblotting analysis. Read More

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http://dx.doi.org/10.1186/s10020-018-0062-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260739PMC
November 2018
4 Reads
4.508 Impact Factor

Urinary capillariosis in a free-ranging Marsican brown bear ().

Int J Parasitol Parasites Wildl 2018 Dec 7;7(3):429-431. Epub 2018 Nov 7.

Dipartimento di Scienze Veterinarie, Viale delle Piagge 2, 56124, Pisa, Italy.

Extraintestinal nematodes have been seldom investigated in the brown bear (). In this study, a case of urinary capillariosis and bladder associated lesions is reported in a deceased free-ranging Marsican brown bear () from Central Italy. Gross lesions in the urinary bladder consisted of scattered foci of mucosal hyperemia, while at histological examination mild cystitis was observed. Read More

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http://dx.doi.org/10.1016/j.ijppaw.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240668PMC
December 2018
1 Read

Safety and efficacy of Intravesical hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome.

Turk J Urol 2018 Nov 21:1-6. Epub 2018 Nov 21.

Department of Urology, Benha University, Benha, Egypt.

Objective: To evaluate the safety and efficacy of intravesical instillation of hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome.

Material And Methods: Forty patients were subjected to intravesical instillations of hyaluronic acid/chondroitin sulfate weekly for 4 weeks and at 6., 8. Read More

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http://dx.doi.org/10.5152/tud.2018.63600DOI Listing
November 2018
1 Read

Chronic Urinary Retention due to Fowler's Syndrome.

European J Pediatr Surg Rep 2018 Jan 18;6(1):e77-e80. Epub 2018 Oct 18.

Department of Paediatric Surgery and Urology, Motol University Hospital, Charles University in Prague, Prague, Czech Republic.

Fowler's syndrome (FS) is a rare cause of chronic urinary retention in teenage girls and young women. We present a case of a 14-year-old girl who presented at our hospital 2 weeks after uncomplicated laparoscopic appendectomy. The girl complained of reduced urinary frequency and prolonged micturition time. Read More

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http://dx.doi.org/10.1055/s-0038-1672147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193800PMC
January 2018
2 Reads

An Overview of the Pathology and Emerging Treatment Approaches for Interstitial Cystitis/Bladder Pain Syndrome.

Cureus 2018 Sep 17;10(9):e3321. Epub 2018 Sep 17.

Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA.

Our article will discuss bladder pain syndrome (BPS), which is the presence of chronic suprapubic pain to bladder filling accompanied by other urinary symptoms, such as frequency, urgency, discomfort with filling, and relief with emptying of the bladder in the absence of infections or other pathology. It is mostly seen in females and occurs in 0.06%-30% of the population. Read More

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https://www.cureus.com/articles/14802-an-overview-of-the-pat
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http://dx.doi.org/10.7759/cureus.3321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248749PMC
September 2018
10 Reads

Recent advances in imaging and understanding interstitial cystitis.

F1000Res 2018 9;7. Epub 2018 Nov 9.

Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating condition associated with intense pelvic pain and bladder storage symptoms. Since diagnosis is difficult, prevalence estimates vary with the methodology used. There is also a lack of proven imaging tools and biomarkers to assist in differentiation of IC/BPS from other urinary disorders (overactive bladder, vulvodynia, endometriosis, and prostatitis). Read More

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http://dx.doi.org/10.12688/f1000research.16096.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234747PMC
November 2018
2 Reads