Search Our Scientific Publications & Authors

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Departments of Urology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Growing evidence suggested that the long noncoding RNAs (lncRNAs) regulate several pathophysiological processes in tumorigenesis and may be new biomarkers for tumor therapy. In this study, we studied the expression and role of lncRNA MT1JP in the development of bladder cancer. We demonstrated that the expression of MT1JP was downregulated in bladder tumor samples and cell lines. Read More

PLoS One 2019 20;14(2):e0210976. Epub 2019 Feb 20.

Department of Aerospace and Mechanical Engineering, Viterbi School of Engineering, University of Southern California, University Park Campus, Los Angeles, CA, United States of America.

Currently in patients with bladder cancer, various clinical evaluations (imaging, operative findings at transurethral resection and radical cystectomy, pathology) are collectively used to determine disease status and prognosis, and recommend neoadjuvant, definitive and adjuvant treatments. We analyze the predictive power of these measurements in forecasting two key long-term outcomes following radical cystectomy, i.e. Read More

Int Braz J Urol 2019 Feb 10;45. Epub 2019 Feb 10.

Hospital Municipal Souza Aguiar, Rio de Janeiro, RJ, Brasil.

Purpose: To study the effect of penile constriction devices used on a large series of patients who presented at our emergency facility. We explored treatment options to prevent a wide range of vascular and mechanical injuries occurring due to penile entrapment.

Materials And Methods: Between January 2001 and March 2016, 26 patients with penile entrapment were admitted to our facility and prospectively evaluated. Read More

Int Braz J Urol 2019 Feb 10;45. Epub 2019 Feb 10.

Departamento de Urologia Hospital Alberto Cavalcanti, Belo Horizonte, MG, Brasil.

To describe a technical modifi cation for robotic-assisted simple prostatectomy (RASP) using three-steps reconstructive technique to achieve a 360 trigonization of the bladder mucosa. Through fi ve-trocars transperitoneal access, we perform a longitudinal incision of the bladder wall and prostate capsule. Our technique of RASP is very similar to the standard operative technique described during laparoscopic and robotic removal of adenoma, however, for reconstruction, we propose the Tunnel-Shaped Trigonization (TST). Read More

Int Braz J Urol 2018 Nov 3;45. Epub 2018 Nov 3.

Department of Urology, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del Sacro Cuore di Roma.

Objectives: To evaluate the neutrophil-to-lymphocyte ratio (NLR) as a prognostic factor for response of high risk non muscle invasive bladder cancer (HRNMIBC) treated with BCG therapy.

Materials And Methods: Between March 2010 and February 2014 in a tertiary center 100 consecutive patients with newly diagnosed HRNMIBC were retrospectively analyzed. Patients were divided according to NLR value: 46 patients with NLR value less than 3 (NLR < 3 group), and 54 patients with NLR value more than 3 (NLR ≥ 3 group). Read More

Cell Rep 2019 Feb;26(8):2241-2256.e4

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

We used whole-organ mapping to study the locoregional molecular changes in a human bladder containing multifocal cancer. Widespread DNA methylation changes were identified in the entire mucosa, representing the initial field effect. The field effect was associated with subclonal low-allele frequency mutations and a small number of DNA copy alterations. Read More

Neoplasma 2019 Feb 20. Epub 2019 Feb 20.

Cancer cell invasion is an important characteristic of malignant tumors. Cancer cells overcome the constraints of tight junctions (TJ) to invade other tissues, but less is known about the regulating role of tight junction on bladder cancer (BC) invasion. In order to identify the invasion-regulating function of tight junction component, we investigated the oncogenetic features of zonula occludens-1 associated nucleic acid binding protein (ZONAB), a TJ protein that is usually highly expressed in solid cancers. Read More

J Pathol Inform 2019 24;10. Epub 2019 Jan 24.

Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA.

This narrative-based paper provides a first-person account of the early history of telepathology (1985-2000) by the field's inventor, Ronald S. Weinstein, M. D. Read More

Urol Int 2019 Feb 18:1-6. Epub 2019 Feb 18.

Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: The purpose of this study was to investigate the association between prophylactic antibiotic administration (PAA) and postoperative infection after radical cystectomy with urinary diversion in patients with invasive bladder cancer.

Methods: Forty-nine consecutive cases were analyzed prospectively. Postoperative infections were categorized as surgical site infection (SSI) and remote infection (RI). Read More

Mol Cancer 2019 Feb 19;18(1):27. Epub 2019 Feb 19.

Department of urology, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646699, China.

Background: Circular RNA (circRNA) represents a broad and diverse endogenous RNAs that can regulate gene expression in cancer. However, the regulation and function of bladder cancer (BC) circRNAs remain largely unknown.

Methods: Here we generated circRNA microarray data from three BC tissues and paired non-cancerous matched tissues, and detected circular RNA-cTFRC up-regulated and correlated with tumor grade and poor survival rate of BC patients. Read More

Trop Doct 2019 Feb 19:49475519829601. Epub 2019 Feb 19.

5 Assistant Professor, Division of Surgical Gastroenterology, Department of General Surgery, PGIMER, Chandigarh, India.

Gall bladder tuberculosis (TB) is a rare entity and differentiation of gall bladder TB from gall bladder malignancy is difficult. We hereby present an unusual case of incidental diagnosis of gall bladder TB during the evaluation of a gall bladder with suspicion of gall bladder cancer in a 49-year-old woman. The diagnosis of gall bladder TB was made with fine needle aspiration cytology (FNAC) from the gall bladder mass as the disease was found unresectable after cross-sectional imaging. Read More

Technol Cancer Res Treat 2019 Jan;18:1533033819831962

1 McGill University, Jewish General Hospital, Montreal, Quebec, Canada.

Purpose:: In this prospective phase II study, we investigated whether cone beam computed tomography scan was a superior method of image-guided radiotherapy relative to 2D orthogonal kilovoltage images in the post-radical prostatectomy setting.

Methods:: A total of 419 treatment fractions were included in this analysis. The shifts required to align the patient for each treatment were performed using 3D matching between cone beam computed tomography scans and the corresponding computed tomography images used for planning. Read More

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

QOPNA & LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

The stabilization of G-Quadruplex DNA structures by ligands is a promising strategy for telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited proliferation of cancer cells. To assess the potential of a compound as a telomerase inhibitor, selectivity for quadruplex over duplex DNA is a fundamental attribute, as the drug must be able to recognize quadruplex DNA in the presence of a large amount of duplex DNA, in the cellular nucleus. By using different spectroscopic techniques, such as ultraviolet-visible, fluorescence and circular dichroism, this work evaluates the potential of a series of multicharged phthalocyanines, bearing four or eight positive charges, as G-Quadruplex stabilizing ligands. Read More

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia.

Six new organotin(IV) compounds of Schiff bases derived from -R-dithiocarbazate [R = benzyl (B), 2- or 4-methylbenzyl (2M and 4M, respectively)] condensed with 2-hydroxy-3-methoxybenzaldehyde (oVa) were synthesised and characterised by elemental analysis, various spectroscopic techniques including infrared, UV-vis, multinuclear (¹H, C, Sn) NMR and mass spectrometry, and single crystal X-ray diffraction. The organotin(IV) compounds were synthesised from the reaction of Ph₂SnCl₂ or Me₂SnCl₂ with the Schiff bases (S2MoVaH/S4MoVaH/SBoVaH) to form a total of six new organotin(IV) compounds that had a general formula of [R₂Sn(L)] (where L = Schiff base; R = Ph or Me). The molecular geometries of Me₂Sn(S2MoVa), Me₂Sn(S4MoVa) and Me₂Sn(SBoVa) were established by X-ray crystallography and verified using density functional theory calculations. Read More

Ann Glob Health 2018 Nov 5;84(4):679-682. Epub 2018 Nov 5.

Department of Radiation Oncology, University of Florida, US.

Background: The purpose of this study is to detail the implementation of HDR brachytherapy at the only radiotherapy center in Nicaragua.

Methods: Patients are treated with external-beam radiotherapy to 46-50Gy at 2Gy/fraction to the pelvis. A gynecologic examination is performed weekly. Read More

J Cell Physiol 2019 Feb 18. Epub 2019 Feb 18.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The presence of inflammatory cells and their products in the tumor microenvironment plays a crucial role in the pathogenesis of a tumor. Releasing the cytokines from a host in response to infection and inflammation can inhibit tumor growth and progression. However, tumor cells can also respond to the host cytokines with increasing the growth/invasion/metastasis. Read More

J Cell Physiol 2019 Feb 18. Epub 2019 Feb 18.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Bladder cancer (BC) is one of the most common neoplastic diseases worldwide. With the highest recurrence rate among all cancers, treatment of BC only improved a little in the last 30 years. Available biomarkers are not sensitive enough for the diagnosis of BC, whereas the standard diagnostic method, cystoscopy, is an invasive test and expensive. Read More

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1022-1029

Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Objective: To elucidate whether lncSNHG14 could influence the proliferative potential and cell cycle progression of bladder cancer cells via binding to microRNA-150-5p (miRNA-150-5p). We aim to investigate the potential mechanism of miRNA-150-5p in the occurrence and progression of bladder cancer (BCa).

Patients And Methods: Expression levels of SNHG14 and miRNA-150-5p in BCa tissues and normal bladder tissues were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Read More

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1012-1021

Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Beijing, China.

Objective: The incidence of bladder cancer (BC) is common in the world, but its detail mechanisms for occurrence and development remain unclear. Recently, long non-coding RNAs (lncRNAs) have been observed to play an important role in many different diseases. In this research, we mainly explored the role of the RNA component of mitochondrial RNA processing endoribonuclease (lncRNA-RMRP) in bladder cancer. Read More

World J Urol 2019 Feb 18. Epub 2019 Feb 18.

Department of Urology, Fundacion Puigvert, University Autonoma of Barcelona, Barcelona, Spain.

Front Oncol 2019 4;9:24. Epub 2019 Feb 4.

Department of Breast Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Hexavalent chromium [Cr(VI)] is an occupational carcinogen that can cause lung and nasal cancers, but its association with mortality and incidence in many other cancers is unclear. In this meta-analysis, we aimed to evaluate the relationship between exposure to Cr(VI) and the mortality and incidence of human cancers. We performed a search of the literature and extracted the standardized mortality ratios (SMRs), standardized incidence ratios (SIRs), and their corresponding 95% confidence intervals (CIs), to estimate risk values. Read More

Br J Cancer 2019 Feb 19. Epub 2019 Feb 19.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: The present study examined whether adult height was associated with all site-combined or site-specific cancers.

Methods: We used a nationwide claim data of 22,809,722 Korean participants including both men and women (2009-2012). The deciles of height from different age and sex groups were merged into a new quintile. Read More

Med Sci Monit 2019 Feb 19;25:1323-1335. Epub 2019 Feb 19.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).

BACKGROUND Chemoresistance is a main limitation in chemotherapy for therapeutic cancer. MicroRNA (miRNA) has been indicated in the progression and tumorigenesis of many types of cancer, but the effect of miR-34b-3p in bladder cancer (BCa) cells is still unknown. MATERIAL AND METHODS This research compared the multidrug-sensitive (5637) BCa cell line and the multidrug-resistant (EJ) BCa cell line. Read More

Thorax 2019 Feb 18. Epub 2019 Feb 18.

Department of Oncology, University of Cambridge, Cambridge, UK.

Background: Lung cancer 5-year survival has doubled over 15 years. Although the risk of second primary cancer is recognised, quantification over time is lacking. We describe the incidence of second and higher order smoking-related primary cancers in lung cancer survivors, identifying high-incidence groups and how incidence changes over time from first diagnosis. Read More

Urol Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Objectives: To evaluate the feasibility and outcomes of a nonopioid (NOP) perioperative pain management protocol for patients undergoing robot-assisted radical cystectomy (RARC).

Materials And Methods: We prospectively included 52 consecutive patients undergoing RARC at our institution for bladder cancer. Patients received a multimodal pain management protocol, including a combination of nonopioid pain medications and regional anesthesia. Read More

J Med Imaging Radiat Sci 2019 Mar 8;50(1):82-86. Epub 2018 Nov 8.

The Austin Hospital, Heidelberg, Australia; Ringwood Private Hospital, Ringwood East, Australia; University of Melbourne, Melbourne, Australia.

Introduction: This is a retrospective study conducted to report the tumor control and late toxicity outcomes of patients with intermediate-risk prostate cancer undergoing combination external beam radiation therapy and low dose rate brachytherapy (LDR-PB).

Methods And Materials: Thirty-one patients received 45 Gray (Gy) of external beam radiation therapy to the prostate and seminal vesicles, together with a brachytherapy boost via a transperineal prostate implant of I (108 Gy). In addition, some patients received 6 months of androgen deprivation therapy depending on physician preference. Read More

J Med Chem 2019 Feb 18. Epub 2019 Feb 18.

The in vitro and in vivo anti-cancer activity of iodinated photosensitizers (PS) with and without erlotinib moiety was investigated in UMUC-3 [epidermal growth factor (EGFR) positive], T24 (EGFR low) cell lines, and tumored mice. Both the erlotinib conjugated PS 3 and 5 showed EGFR target specificity, but the position-3 erlotinib-PS conjugate 3 demonstrated lower photodynamic therapy (PDT) efficacy than the corresponding non-erlotinib analog 1, whereas the conjugate 5 containing an erlotinib moiety at position-17 of the PS gave higher tumor-uptake and long-term tumor cure (SCID mice bearing UMUC-3 tumors). PS-erlotinib conjugates in the absence of light were ineffective in vitro and in vivo, but robust apoptotic and necrotic cell death was observed in bladder cancer cells after exposing them with a laser light at 665 nm. Read More

ACS Omega 2019 Jan 16;4(1):1470-1478. Epub 2019 Jan 16.

Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, V5Z 1L3 Vancouver, British Columbia, Canada.

The gastrin-releasing peptide receptor (GRPR), a G protein-coupled receptor, is overexpressed in solid malignancies and particularly in prostate cancer. We synthesized a novel bombesin derivative, [Ga]Ga-ProBOMB1, evaluated its pharmacokinetics and potential to image GRPR expression with positron emission tomography (PET), and compared it with [Ga]Ga-NeoBOMB1. ProBOMB1 (DOTA-pABzA-DIG-d-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-ψ(CHN)-Pro-NH) was synthesized by solid-phase peptide synthesis. Read More

Asian J Urol 2019 Jan 8;6(1):114-121. Epub 2018 Jun 8.

Department of Urology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Objective: To evaluate the diagnostic value of fluorescence hybridization (FISH) in bladder cancer.

Methods: We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008. Receiver operating characteristic (ROC) curve analysis was performed and the area under curve (AUC) values were calculated for both the FISH and urine cytology tests. Read More

Oncotarget 2019 Jan 18;10(6):684. Epub 2019 Jan 18.

Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, PR China.

[This corrects the article DOI: 10.18632/oncotarget.10575. Read More

Clin Epidemiol 2019 23;11:133-143. Epub 2019 Jan 23.

Centre for Pharmacoepidemiology, Department of Medicine, Karolinska Institute, Solna, Sweden,

Introduction: One out of six adults has symptoms of overactive bladder (OAB). Antimuscarinic medication is the main pharmacological group used in the treatment of OAB. In preclinical studies, antimuscarinic compounds have been found to inhibit cell proliferation in lung cancer and colon cancer. Read More

Expert Rev Proteomics 2019 Feb 16. Epub 2019 Feb 16.

a Department of Molecular and Cell Biology , Baylor College of Medicine , Houston , TX , USA.

Introduction: Metabolomics is a chemical process, involving the characterization of metabolites and cellular metabolism. Recent studies indicate that numerous metabolic pathways are altered in bladder cancer (BLCA), providing potential targets for improved detection and possible therapeutic intervention. We review recent advances in metabolomics related to BLCA and identify various metabolites that may serve as potential biomarkers for BLCA. Read More

Occup Environ Med 2019 Feb 16. Epub 2019 Feb 16.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Objectives: To quantitatively evaluate exposure-response associations between occupational exposures to rubber dust, fumes and N-nitrosamines and cancer mortality in the UK rubber industry.

Methods: Competing risk survival analyses were used to examine cancer mortality risk in a cohort of 36 441 males aged 35+ years employed in the British rubber industry in 1967, followed up to 2015 (94% mortality). Exposure measurements are based on a population-specific quantitative job-exposure matrix for rubber dust, rubber fumes and N-nitrosamines from the EU-EXASRUB project. Read More

Pract Radiat Oncol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiation Oncology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510 Japan.

Purpose: The purpose of this work is to demonstrate quantitatively the complementary relation between the introduction of intensity-modulated radiation therapy (IMRT) and planning target volume (PTV) margin reduction with an image-guided technique in reducing the risk of rectal toxicity in dose-escalating prostate radiation therapy.

Methods And Materials: 3D-CRT and IMRT plans were generated for 10 prostate cancer patients based on two PTV margin protocols (10/8 mm and 6/5 mm) and two dose prescriptions (70 Gy and 78 Gy). The normal tissue complication probability (NTCP) for each of eight scenarios was calculated using the Lyman-Kutcher-Burman (LKB) model to estimate the risk of rectal and bladder late toxicity. Read More

Eur Urol Focus 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA.

Background: Centralization of radical cystectomy (RC) to "high volume" centers can lead to decreased morbidity but also limits access to care. In the context of centralization, there is a need to systematically define the hospital volume cutoffs for this procedure.

Objective: To systematically examine the effect of hospital volume on inpatient complications of RC for bladder cancer and to define a threshold to minimize RC morbidity. Read More

Biochem Pharmacol 2019 Feb 14;163:133-141. Epub 2019 Feb 14.

Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China. Electronic address:

Palbociclib is a Cdk4/6 inhibitor approved for metastatic estrogen receptor-positive breast cancer. The drug is also under clinical evaluation for metastatic urothelial cancer and other solid tumors. Preclinical studies from multiple tumor types suggest that other factors also affect the sensitivity of individual tumors to Cdk4/6 inhibitor. Read More

Phys Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Oncology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark.

Purpose: To provide an analysis of dose distribution in sub-structures that could be responsible for urinary toxicity after Image-Guided Adaptive BrachyTherapy (IGABT) in Locally Advanced Cervical Cancer (LACC).

Methods: 105 LACC patients treated with radiochemotherapy and IGABT were selected. Sub-structures (bladder wall, trigone, bladder neck, urethra) were contoured on IGABT-planning MRIs. Read More

Cancer Epidemiol 2019 Feb 13;59:135-142. Epub 2019 Feb 13.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada.

Background: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age.

Materials And Methods: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified. Read More

Neuroscience 2019 Feb 13. Epub 2019 Feb 13.

Programa de Pós-Graduação em Ciências Biológicas-Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Several studies have demonstrated the antitumor effect of doxazosin, an α1-adrenergic blocker, against glioma and breast, bladder and prostate cancers. Doxazosin is also being evaluated as a treatment for posttraumatic stress disorder and alcoholism, and α1-adrenergic blockers have been linked to neuroprotection in neurodegenerative disorders, such as Alzheimer's Disease (AD). Cancer and AD have an inverse relationship in many aspects, with several factors that contribute to apoptosis inhibition and proliferation being increased in cancers but decreased in AD. Read More

Clin Immunol 2019 Feb 13;201:4-14. Epub 2019 Feb 13.

Tianjin Institute of Urology, Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, PR China.

Bacillus Calmette-Guerin (BCG) is one of the most effective treatments for bladder cancer. Little attention has been paid to the possible role of neutrophils in BCG immunotherapy. In this study, we examined neutrophil extracellular traps (NETs) formation induced by BCG stimulation, and found that BCG-induced NETs exerted cytotoxicity, induced apoptosis and cell-cycle arrest, and inhibited migration in bladder tumor cells. Read More

Transl Res 2019 Feb 7. Epub 2019 Feb 7.

Department and Laboratory of Urology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre de Recerca Biomèdica CELLEX, Universitat de Barcelona, Barcelona, Spain. Electronic address:

This study aimed to improve our previous urine gene expression classifiers focusing on the detection of non-high-risk non-muscle-invasive bladder cancer (NMIBC), and develop a new classifier able to decrease the frequency of cystoscopies during bladder cancer (BC) patients' surveillance. A total of 597 urines from BC patients, controls and patients in follow-up for BC (PFBC) were included. The study has 3 phases. Read More

Trials 2019 Feb 15;20(1):133. Epub 2019 Feb 15.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuai Fu Yuan, Dongcheng District, Beijing, 100730, People's Republic of China.

Background: Urinary catheter placement is essential before laparoscopic anterior resection for rectal cancer. Whether early removal of the catheter increases the incidence of urinary retention and urinary tract infection (UTI) is not clear. This study aims to determine the optimal time for removal of the urinary catheter after laparoscopic anterior resection of the rectum. Read More

Acta Obstet Gynecol Scand 2019 Feb 15. Epub 2019 Feb 15.

The Fertility Clinic, section 4071, University Hospital of Copenhagen Rigshospitalet, Copenhagen, Denmark.

Introduction: Ovarian tissue cryopreservation (OTC) is increasingly offered to women in need of fertility preservation. However, little is known about the risk of these women dying before they use the preserved material.

Material And Methods: From 1999 to 2016, 927 girls and women underwent OTC in our center, prior to receiving gonadotoxic treatment. Read More

Urol Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Mayo Clinic Hospital, Phoenix, AZ. Electronic address:

Objectives: The length-of-stay (LOS) benefit of minimally invasive cystectomy varies in the published literature, potentially because of subgroup effects. Here, we investigated the effect of minimally invasive cystectomy on LOS among different age groups.

Methods And Materials: Adult patients who underwent cystectomy (open or minimally invasive) from January 1, 2012, to December 31, 2016, were identified from the National Surgical Quality Improvement Program database. Read More

Am J Pathol 2019 Feb 9. Epub 2019 Feb 9.

Department of Biophysics, Ruhr University Bochum, Bochum, Germany. Electronic address:

Histopathological differentiation between severe urocystitis with reactive urothelial atypia and carcinoma in situ (CIS) can be difficult, particularly after a treatment that deliberately induces an inflammatory reaction, such as intravesical instillation of Bacillus Calmette-Guèrin. However, precise grading in bladder cancer is critical for therapeutic decision making and thus requires reliable immunohistochemical biomarkers. Herein, an exemplary potential biomarker in bladder cancer was identified by the novel approach of Fourier transform infrared imaging for label-free tissue annotation of tissue thin sections. Read More

Int J Mol Sci 2019 Feb 14;20(4). Epub 2019 Feb 14.

Flemish Institute for Technological Research (VITO), 2400 Mol, Belgium.

Diagnostic methods currently used for bladder cancer are cystoscopy and urine cytology. Cystoscopy is an invasive tool and has low sensitivity for carcinoma in situ. Urine cytology is non-invasive, is a low-cost method, and has a high specificity but low sensitivity for low-grade urothelial tumors. Read More

PLoS One 2019 15;14(2):e0211780. Epub 2019 Feb 15.

Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America.

Current efforts to assess human health response to chemicals based on high-throughput in vitro assay data on intra-cellular changes have been hindered for some illnesses by lack of information on higher-level extracellular, inter-organ, and organism-level interactions. However, a dose-response function (DRF), informed by various levels of information including apical health response, can represent a template for convergent top-down, bottom-up analysis. In this paper, a general DRF for chronic chemical and other health stressors and mixtures is derived based on a general first-order model previously derived and demonstrated for illness progression. Read More

Andrology 2019 Feb 15. Epub 2019 Feb 15.

Department of Urology, University of Washington Medical Center, Seattle, WA, USA.

Background: In the United States of America (USA), cannabis is legal in 28 states for medical purposes and 8 states for recreational use. In 2016, the legal marijuana industry reached nearly $7 billion in sales in the USA alone. Although consumption continues to increase, the medical effects of marijuana remain understudied. Read More

Vet Comp Oncol 2019 Feb 15. Epub 2019 Feb 15.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian.

The inducible inflammatory enzyme cyclooxygenase-2 (COX-2) and its product prostaglandin E2 (PGE ) are prominent tumour promoters, and expression of COX-2 is elevated in a number of tumours of both humans and canines. Targeting COX-2 in cancer is an attractive option due to readily available non-steroidal anti-inflammatory drugs (NSAIDs), and there is a clear epidemiological link between NSAID use and cancer risk. In this study we aim to establish the anti-tumourigenic effects of the selective, long-acting COX-2 inhibitor mavacoxib. Read More

Support Care Cancer 2019 Feb 14. Epub 2019 Feb 14.

Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, Toronto, Canada.

Background: To date, little research has examined the quality of life and cancer-associated needs of bladder cancer patients. The objective of the current study was to assess the quality of life (QoL), informational needs, and supportive care needs (SCN) in a large sample of muscle invasive (MIBC) and non-muscle invasive (NMIBC) bladder cancer survivors across the treatment trajectory (newly diagnosed and undergoing treatment, post-treatment follow-up, and treatment for advanced/recurrent disease).

Methods: Questionnaires were distributed to a convenience sample of patients registered with Bladder Cancer Canada, the Princess Margaret Cancer Centre, or The Ottawa Hospital. Read More