176,102 results match your criteria Bladder Cancer
Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):289-295. Epub 2018 Dec 12.
Objective: Transitional cell carcinoma (TCC) is the most common malignant tumour of the canine urinary tract. Previously, the mutation of the BRAF gene V595E was identified in approximately 85 % of canine TCC cases by DNA sequencing of TCC tumour cells, both in frozen and paraffin-embedded tissue sections, as well as in urine. The objective of this study was to establish these methods in cytological smears and to investigate the prevalence of BRAF mutation V595E in canine TCC in our cohort of patients. Read More
Magy Onkol 2018 Dec 31;62(4):242-248. Epub 2018 Aug 31.
Onkológiai Tanszék, Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Hungary.
Our aim was the dosimetric evaluation of intracavitary-interstitial high-dose-rate image-guided adaptive cervix brachytherapy, implemented in Hungary. Between 2016 and 2018, 21 patients with cervical cancer were treated with overall 72 fractions. Graphical optimized treatment plans were compared to inverse optimized plans, 3D optimized plans (without needles) and conventional intracavitary 2D plans. Read More
J Spinal Cord Med 2018 Dec 12:1-6. Epub 2018 Dec 12.
c The Department of Physical Medicine and Rehabilitation , Hitit University Medical School , Çorum , Turkey.
Objective: To compare urodynamic findings between patients with complete and incomplete traumatic spinal cord injuries (SCI) and to determine whether it is important to test with urodynamic study in patients with incomplete SCI.
Design: Retrospective study Setting: Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey Participants: A total of 66 patients with 36 complete and 30 incomplete traumatic SCI were included in the study, from July 2012 to September 2014.
Interventions: Urodynamic study Outcome Measures: Maximum cystometric capacity (MCC) , vesicle pressure at MCC, detrusor function (detrusor overactivity or not), bladder complience, bladder storage and emptying disorders, post-void residual volume (PVR) and bladder emptying method were recorded. Read More
J Cancer Res Ther 2018 Dec;14(Supplement):S993-S997
Department of Urology, Wenzhou People's Hospital, Wenzhou, Zhejiang, China.
Aim Of Study: To further evaluate the influence of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null genotypes on bladder cancer risk, we conducted a meta-analysis in the Chinese population.
Materials And Methods: PubMed and Chinese databases were electronically searched through April 2016.
Results: Nine studies were included for our meta-analysis, involving 1646 bladder cancer cases and 1938 controls. Read More
Urol Oncol 2018 Dec 24;36(12):530.e7-530.e18. Epub 2018 Oct 24.
Department of Pathology and Department of Clinical and Experimental Medicine, Medical Faculty, Linköping University, SE 581 85, Linköping, Sweden.
Purpose: We investigated the effects of alterations in the biological markers p14, p53, p21, and p16 in relation to tumour cell proliferation, T-category, N- category, lymphovascular invasion, and the ability to predict prognosis in patients with muscle-invasive bladder cancer (MIBC) treated with cystectomy and, if applicable, chemotherapy.
Materials And Methods: We prospectively studied patients with urinary bladder cancer pathological stage pT1 to pT4 treated with cystectomy, pelvic lymph node dissection and postoperative chemotherapy. Tissue microarrays from paraffin-embedded cystectomy tumour samples were examined for expression of immunostaining of p14, p53, p21, p16 and Ki-67 in relation to other clinical and pathological factors as well as cancer-specific survival. Read More
J Cancer Res Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.
Department of Urology, The First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhong Shan 2nd Road, Guangzhou, 510080, China.
Objective: Comparing intra-arterial chemotherapy combined with intravesical chemotherapy against intravesical chemotherapy alone in the treatment of T1-staged Grade 3 (T1G3) bladder cancer after transurethral resection of bladder tumor (TURBT).
Materials And Methods: From January 2007 to December 2012, 203 patients diagnosed with NMIBC were randomly assigned into either intra-arterial chemotherapy combined with intravesical chemotherapy group (Group A, n = 68) or intravesical chemotherapy alone group (Group B, n = 135) after TURBT. Four cycles of intra-arterial chemotherapy were administered after initial TURBT with 1-month interval between each. Read More
J Cancer Res Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, USA.
Purpose: In certain cancer settings, a T-cell response to cancer represents a relatively favorable outcome. Thus, the near-future challenges include a better understanding of exactly which T-cell features contribute to a response to which cancer antigen-groups, to maximize the opportunities for tumor-infiltrating lymphocyte (TIL)-based therapies and other immunotherapies.
Methods: The immune receptor complementarity determining region-3 (CDR3) is considered to be important for antigen binding, hence, in this report, we evaluated the chemical features of the CDR3 of 846 T-cell receptor-α (TCR-α) coding regions associated with bladder tumor tissue, using bioinformatics databases. Read More
Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.
Department of Radiology, Hospital Sírio-Libanês, Adma Jafet, 91, Bela Vista, São Paulo, SP, 01308-050, Brazil.
Purpose: The aim of this study is to provide an overview of endometriosis-associated neuropathy and to review main anatomical concepts of intrapelvic peripheral nerves.
Methods: In this pictorial essay, we review the anatomy of pelvic nerves and imaging features of endometriosis-associated neuropathy. We also evaluate clinical findings, imaging features, and outcome of seven patients with endometriosis-associated neuropathy. Read More
Open Vet J 2018 19;8(4):441-444. Epub 2018 Nov 19.
Hokkaido University Veterinary Teaching Hospital, Kita 19, Nishi 10, Kita-ku, Sapporo, Hokkaido 060-0819, Japan.
A 10-year-old castrated male cross-breed dog was referred for the repair of perineal hernia with bladder retroflexion and a mass lesion in the hernial sac. Surgical treatment was performed and the mass was identified as degenerated adipose tissue that was suspected to be derived from the omentum. The hernial contents were reduced without difficulty, and the dog exhibited a normal recovery. Read More
J Radiosurg SBRT 2018 ;5(4):331-334
Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.
Introduction: Stereotactic body radiotherapy (SBRT) of the spine has become an increasingly utilized modality in the United States, most commonly for metastatic disease (McClelland et al., 2017). Spinal SBRT in patients with spinal instrumentation has been sparsely examined. Read More
Clin Epidemiol 2018 26;10:1755-1763. Epub 2018 Nov 26.
Research Centre for Cancer Diagnosis in Primary Care (CaP), Research Unit for General Practice, Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark,
Purpose: Recurrence of cancer is not routinely registered in the national registers in Denmark. The aim of this study was to develop and validate a register-based algorithm to identify patients diagnosed with recurrence of invasive bladder cancer (BC).
Materials And Methods: We performed a cohort study based on data from Danish national health registers. Read More
Int J Nanomedicine 2018 19;13:7623-7631. Epub 2018 Nov 19.
Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China,
Background: Chemotherapy after transurethral resection is commonly recommended for bladder cancer. However, studies have shown that chemotherapy solely can hardly decrease progression rates of bladder cancer. The combination of chemotherapeutic agents with photo-dynamic therapy (PDT), a new promising localized therapy, may become a workable strategy for combating bladder cancer. Read More
Indian J Surg Oncol 2018 Dec 16;9(4):644-646. Epub 2018 May 16.
Department of Surgical Oncology, Bombay Hospital, Bombay Hospital Marg, Marine Drive, Mumbai, 400020 India.
Sarcomatoid carcinoma is an extremely rare aggressive tumor variant comprising about 0.3% of all primary tumors of the urinary bladder and carries an overall dismal prognosis. Diagnosis is important and is sometimes difficult. Read More
Indian J Surg Oncol 2018 Dec 23;9(4):547-551. Epub 2018 Jul 23.
5Department of Biotechnology and Microbiology, Karnatak University, Dharwad, 580003 Karnataka India.
Involvement of the bladder by colorectal cancer is sufficiently rare to be encountered by an individual surgeon on an infrequent basis. Extirpative procedures for advanced colorectal cancers can involve partial/total bladder resections. In patients without evidence of distant metastatic disease, a reasonable therapeutic effect can be expected when negative surgical margins are obtained. Read More
Curr Health Sci J 2015 Jul-Sep;41(3):219-226. Epub 2015 Jan 29.
Pathology Department, University of Medicine and Pharmacy of Craiova, Romania.
Purpose: Epithelial mesenchymal transition consists in the acquisition of neoplastic epithelial cells of a mesenchymal phenotype the process being involved in cancers invasion and metastasis. In this study were analyzed the expression of N-cadherin, Twist and Vimentin in bladder urothelial carcinomas according to the main prognostic parameters.
Material/methods: The study included 20 bladder urothelial carcinomas which were analyzed histopathological, immunohistochemical and statistical. Read More
J Cardiol Cases 2014 Mar 12;9(3):91-93. Epub 2013 Dec 12.
Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan.
A 79-year-old woman undergoing medical treatment with solifenacin and clenbuterol for urinary incontinence was admitted to our hospital because of recurrent syncope. Her syncope appeared one month after the doses of clenbuterol were increased. Torsade de pointes (TdP) was evident on her Holter electrocardiogram at the time when she developed syncope. Read More
J Cardiol Cases 2012 Feb 21;5(1):e39-e43. Epub 2011 Nov 21.
Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.
Background: We report a rare case of acute pulmonary embolism (PE) induced by urinary retention and bladder distention with benign prostatic hyperplasia (BPH).
Case Report: A 76-year-old male with BPH presented to the hospital with anuria of 24 h duration and abdominal distention. Physical examination revealed tenderness and distention of the lower abdomen and a swollen right leg. Read More
BJU Int 2018 Dec 11. Epub 2018 Dec 11.
Department of Urology, Antwerp University Hospital, Edegem, Belgium.
Objectives: To assess clinical follow-up data over 24 months using the standardized tined lead implantation technique, comparing the use of the curved vs straight stylet.
Patients And Methods: Single tertiary center, prospective study (August 2013 - June 2015) involving 40 patients with overactive bladder and 15 with non-obstructive urinary retention refractory to first-line treatment.
Primary Outcome: successful tined lead procedure; intention to treat analysis at 12 and 24 months. Read More
J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
FAM83H-AS1, also known as oncogenic long noncoding RNA (lncRNA)-3, is a novel lncRNA that has been suggested to be dysregulated in a variety of human cancers. However, the expression status and function of FAM83H-AS1 in bladder cancer are still unknown. The object of our study is to explore the clinical value of FAM83H-AS1 in patients with bladder cancer and the biological function of FAM83H-AS1 in bladder cancer cells. Read More
J Physiol 2018 Dec 7. Epub 2018 Dec 7.
Department of Pharmacology, University of Vermont, Burlington, VT, 05405.
Key Points Summary: K 7 channels are a family of voltage-dependent K channels expressed in many cell types, which open in response to membrane depolarization to regulate cell excitability. Drugs that target K 7 channels are used clinically to treat epilepsy. Interestingly, these drugs also cause urinary retention, but it was unclear how. Read More
J Appl Clin Med Phys 2018 Dec 7. Epub 2018 Dec 7.
Department of Oncology Physics, Edinburgh Cancer Centre, Western General Hospital, Edinburgh, UK.
Background: Independent verification of the dose delivered by complex radiotherapy can be performed by electronic portal imaging device (EPID) dosimetry. This paper presents 5-yr EPID in vivo dosimetry (IVD) data obtained using the Dosimetry Check (DC) software on a large cohort including breast, lung, prostate, and head and neck (H&N) cancer patients.
Material And Methods: The difference between in vivo dose measurements obtained by DC and point doses calculated by the Eclipse treatment planning system was obtained on 3795 radiotherapy patients treated with volumetric modulated arc therapy (VMAT) (n = 842) and three-dimensional conformal radiotherapy (3DCRT) (n = 2953) at 6, 10, and 15 MV. Read More
Med Phys 2018 Dec 11. Epub 2018 Dec 11.
Department of Radiation Oncology, Stanford University, 875 Blake Wilbur Drive, Stanford, CA, 94305-5847, USA.
Purpose: Few features characterizing the dosimetric properties of the patients are included in currently available dose-volume histogram (DVH) prediction models, making it intractable to build a correlative relationship between the input and output parameters. Here we use PTV-only treatment plans of the patients (i.e. Read More
Eur J Nucl Med Mol Imaging 2018 Dec 11. Epub 2018 Dec 11.
Departments of Radiology and Medical Physics, University of Wisconsin - Madison, 1111 Highland Avenue, Madison, WI, 53705, USA.
Genes Genomics 2018 Dec 8. Epub 2018 Dec 8.
Department of Informatics, University of Evora, 7004-516, Evora, Portugal.
Background: Identification of differentially expressed genes, i.e., genes whose transcript abundance level differs across different biological or physiological conditions, was indeed a challenging task. Read More
Int Urogynecol J 2018 Dec 7. Epub 2018 Dec 7.
James Cook University Hospital, Middlesbrough, TS4 3BW, UK.
Introduction And Hypothesis: Sexual function is being increasingly recognized as an important patient-reported outcome. Sacral neuromodulation (SNM) is a treatment with an expanding list of indications. The effect of sacral neuromodulation on sexual function has been examined in a number of studies with variable results. Read More
World J Urol 2018 Dec 10. Epub 2018 Dec 10.
Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.
Purpose: To develop and validate novel nomograms to predict recurrence and progression after transurethral resection of bladder tumor (TURBT) in Korean patients with non-muscle-invasive bladder cancer (NMIBC).
Methods: We retrospectively analyzed the clinical data on 970 newly diagnosed NMIBC patients after TURBT between 2000 and 2013 in a single institution. We used multivariate Cox proportional hazard models to identify the significant predictors of recurrence and progression, which resulted in the construction of the nomograms predicting the 5-year probability of recurrence and progression. Read More
World J Urol 2018 Dec 10. Epub 2018 Dec 10.
Sino-Singapore Eco-city Hospital of Tianjin Medical University, No. 3333, Hechang Road, Binhai New Area, Tianjin City, 300467, China.
Background: Bladder cancer is the most common malignancy of urinary system with high morbidity and mortality. In general, the development and progression of bladder cancer are complicated pathological processes, and the treatment methods mainly include surgical resection, radiotherapy, chemotherapy, and combined therapy. In recent years, targeted therapy has made progress in the treatment of bladder cancer. Read More
World J Urol 2018 Dec 7. Epub 2018 Dec 7.
H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Introduction: Intravesical therapy has been an important aspect of the management of non-muscle invasive bladder cancer (NMIBC) for 40 years. Bacillus Calmette-Guerin (BCG) is considered standard of care for intermediate and high-grade non-invasive disease, yet understanding the nuances of subsequent intravesical therapy is important for any provider managing bladder cancer. Herein, we review the literature and describe optimal use of intravesical therapies for NMIBC. Read More
Rom J Morphol Embryol 2018 ;59(3):773-780
Department of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital, Clinical Department No. 3, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;
The aim of the study was to observe similarities and differences regarding surgical safety and prognosis between en bloc bipolar resection and monopolar transurethral resection of bladder tumors (TURBTs) in medium size papillary non-muscle invasive bladder tumors (NMIBTs). A total of 90 patients with papillary bladder tumors presenting a diameter between 1 and 3 cm were equally divided and alternatively assigned for en bloc bipolar ablation (the study group) and conventional TURBT (the control group). During one year, every three months, the follow-up was performed and the protocol included urinary cytology and cystoscopy. Read More
Rom J Morphol Embryol 2018 ;59(3):755-762
Department of Research Methodology, University of Medicine and Pharmacy of Craiova, Romania;
Multiple sclerosis (MS) is a complex chronic neurodegenerative disease that involves an abnormal autoimmune response directed against the brain, nerves and spinal cord; it is considered the most frequent cause of neurological disability, because MS-associated inflammatory lesions can affect a wide range of systems to a varying degree and may cause a plethora of neurological comorbidities and symptoms. The symptoms are quite variable from patient to patient and depend on the spatial distribution of the central nervous system (CNS) lesions, but usually involve sensory disturbances, cognitive deficits, unilateral vision loss, bladder dysfunction, ataxia, fatigue, double vision, weakness of the limbs and intestinal disorders. Experimental autoimmune encephalitis (EAE) mouse model reproduces the pathological features of the human disease, and is a widely used model used for studying the pathology and different treatment options in the preclinical stage. Read More
Case Rep Hematol 2018 11;2018:9750532. Epub 2018 Nov 11.
Physician, General Medicine, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa 7770199, Santiago, Chile.
Myelodysplasia is a clonal disorder characterized by progressive cytopenias. Intravescial BCG is standard immunotherapy for superficial bladder cancer. We present a patient with transfusion-dependent myelodysplasia whose blood counts normalized during treatment with intravesical BCG for bladder cancer. Read More
Arab J Urol 2018 Dec 18;16(4):441-445. Epub 2018 May 18.
Department of Urology, Hisar Intercontinental Hospital, Istanbul, Turkey.
Objective: To evaluate the effectiveness and safety of bilateral same-session flexible ureterorenoscopy (f-URS) in the treatment of bilateral renal and/or ureteric stone disease.
Patients And Methods: From October 2007 to December 2015, 62 patients who had undergone bilateral, same-session f-URS were included in the study. The procedures were performed under general anaesthesia, in lithotomy, and initiated on the side in which the patient was clinically symptomatic or on the side in which the stone was smaller. Read More
Arab J Urol 2018 Dec 26;16(4):422-428. Epub 2018 Jul 26.
Department of Urology, Benha Faculty of Medicine, Benha University, Benha, Egypt.
Objective: To evaluate the efficacy of silodosin therapy, as a new α-adrenergic receptor (α-AR) blocker, on the success rate of semi-rigid ureteroscopy (URS) for the management of large distal ureteric stones.
Patients And Methods: This prospective study recruited 127 adult patients with single distal ureteric stone of ≥1 cm. The patients were randomly allocated to two groups: the first group included 62 patients who received silodosin (8 mg) for 10 days before URS (Silodosin group), whilst the second group included 65 patients who received placebo, in the form of multivitamins, for 10 days before URS (Placebo group). Read More
Arab J Urol 2018 Dec 11;16(4):417-421. Epub 2018 Jun 11.
M.S. Ramaiah Hospital, Bangalore, India.
Objective: To describe the effectiveness and safety of our novel technique of simultaneous percutaneous cystolithotripsy with transurethral resection of prostate (TURP) for patients with benign prostatic hyperplasia (BPH) complicated with large vesical calculi.
Patients And Methods: This was a retrospective analysis of 25 patients who underwent simultaneous percutaneous cystolithotripsy with TURP between January 2012 and January 2016. Technique: A 28-F Amplatz sheath was inserted percutaneously into the bladder after sequential dilatation under cystoscopic guidance. Read More
Arab J Urol 2018 Dec 5;16(4):411-416. Epub 2018 Jul 5.
Department of Urology and Men's Health, Al Garhoud Private Hospital, Dubai, United Arab Emirates.
Objectives: To report our experience with the emerging technique of thulium laser enucleation of the prostate (ThuLEP) for the treatment for prostate hyperplasia.
Patients And Methods: Our inclusion criteria were an International Prostate Symptom Score (IPSS) of >15 and a quality-of-life (QoL) score of >3 in patients with confirmed bladder outflow obstruction, no longer responsive to medical therapy, with a significant post-void residual urine volume (PVR; >100 mL), with or without recurrent urinary tract infection and/or acute urinary retention. Patients with neurogenic bladder, urethral strictures, bladder stones, and previously failed transurethral prostate surgery were excluded. Read More
Arab J Urol 2018 Dec 7;16(4):391-396. Epub 2018 Aug 7.
Department of Neurosurgery, Al-Mustansiriya University, Baghdad, Iraq.
Objectives: To present our experience, in Iraq, with sacral neuromodulation (SNM) in patients with refractory lower urinary tract dysfunction, with discussion of the factors that affect the response rate.
Patients And Methods: In this prospective, clinical, interventional study, 24 patients were evaluated and treated by a team comprised of a Urologist and a Neurosurgeon with SNM over a 1.5-year period. Read More
Arab J Urol 2018 Dec 14;16(4):386-390. Epub 2018 Jul 14.
Department of Urology, Christian Medical College and Hospital, Vellore, Tamilnadu, India.
Objective: To identify primary tumour-related factors at transurethral resection of bladder tumour (TURBT) that may predict positive distal ureteric margins (PUM) at the time of radical cystectomy (RC).
Patients And Methods: A retrospective, cohort study was conducted using our institution's data from June 2007 to June 2016. Patients who underwent TURBT followed by RC for non-metastatic urothelial carcinoma (UC) of the bladder were identified. Read More
Nurs Open 2019 Jan 14;6(1):109-115. Epub 2018 Sep 14.
School of Nursing and Midwifery Dezful University of Medical Sciences Dezful Iran.
Aim: The present study aimed to determine the level of applying safety standards in treatment and therapy processes.
Design: In the present descriptive study, 120 cases of nasogastric intubation, bladder catheterization and intramuscular and intravenous injections done by emergency staff were randomly selected.
Methods: The data were collected by a two-section checklist including demographic features and four sheets of observation. Read More
Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):510-516. Epub 2018 Oct 19.
Department of Radiation Oncology, Hospital de Navarra, Pamplona, Spain.
Purpose: To evaluate dosimetric and clinical findings of MRI-guided HDR brachytherapy (HDR-B) for cervical carcinoma.
Material And Methods: All patients had a CT, MRI and pelvic-paraaortic lymphadenectomy. Treatment: pelvic (+/-)para-aortic3D/IMRT radiotherapy (45 Gy), weekly cisplatin and HDR-B and pelvic node/parametrial boost 60 Gy until interstitial brachytherapy was done. Read More
Turk J Emerg Med 2018 Dec 23;18(4):170-171. Epub 2018 Feb 23.
TOBB Economy and Technology University, Faculty of Medicine, Department of Urology, Yaşam Caddesi No: 5 Söğütözü, 06510, Ankara, Turkey.
Urinary retention is defined as the inability to void; frequently the patient is able to void partially, thus can not completely empty the bladder and diagnosed by increased post-void residual urine (PVR) volumes. It is usually seen in men, but a rare condition in women. The etiological factors may be neurological, anatomical, infectious or pharmacological. Read More
Bladder Cancer 2018 3;4(Suppl 1):S14-S15. Epub 2018 Oct 3.
Division of Urology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
Res Rep Urol 2018 16;10:219-225. Epub 2018 Nov 16.
Department of Surgery, Division of Urology, Duke University Medical Center, Durham, NC, USA,
Purpose: Diabetes is a grave and progressive condition characterized by debilitating complications. Diabetic bladder dysfunction (DBD) is a very common complication with no specific treatments currently available. Unlike other tissues affected by this disease, the bladder is subjected to two independent insults; 1) polyuria, created by the osmotic effects of glucose in the urine, and 2) hyperglycemia itself. Read More
PeerJ 2018 4;6:e6036. Epub 2018 Dec 4.
Central Laboratory, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, China.
Background: Bladder cancer is a malignant tumor in the urinary system with high mortality and recurrence rates. However, the causes and recurrence mechanism of bladder cancer are not fully understood. In this study, we used integrated bioinformatics to screen for key genes associated with the development of bladder cancer and reveal their potential molecular mechanisms. Read More
Pain 2018 Dec 5. Epub 2018 Dec 5.
Visceral Pain Research Group, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, 5042, AUSTRALIA.
Primary afferent neurons transduce distension of the bladder wall into action potentials that are relayed into the spinal cord and brain, where autonomic reflexes necessary for maintaining continence are coordinated with pathways involved in sensation. However, the relationship between spinal circuits involved with physiological and nociceptive signalling from the bladder have only been partially characterised. We used ex-vivo bladder afferent recordings to characterise mechanosensitive afferent responses to graded distension (0-60mmHg) and retrograde tracing from the bladder wall to identify central axon projections within the dorsal horn of the lumbosacral spinal cord. Read More
Biomed Res 2018 ;39(6):269-277
Department of Biochemistry, Graduate School of Medicine, University of the Ryukyus.
Pelvic venous congestion (PC) is thought to be related to several diseases of the lower urinary tract (LUT). We examined the characteristics of the LUT in rats with PC. To create PC, female rats were anesthetized with isoflurane, and the bilateral common iliac veins and bilateral uterine veins were ligated. Read More
Neural Regen Res 2019 Jan;14(1):149-155
Department of Neurosurgery, PLA General Hospital, Beijing, China.
Tethered cord syndrome is a progressive disease with a typically insidious onset in infants and children, and which can lead to persistent progress of neurological deficits and a high rate of disability without timely intervention. The purpose of this study was to investigate the curative effect of microsurgery in children with different types of tethered cord syndrome. In this study, we analyzed 326 patients with tethered cord syndrome, aged from 2 months to 14 years old, who were followed for 3-36 months after microscopic surgery. Read More
Neural Regen Res 2019 Feb;14(2):222-226
Department of Neural & Behavioral Sciences, Penn State University College of Medicine, Hershey, PA, USA.
The devastating losses following traumatic spinal cord injury (SCI) encompass the motor, sensory and autonomic nervous systems. Neurogenic bowel is a slow transit colonic dysfunction marked by constipation, rectal evacuation difficulties, decreased anorectal sensation, fecal incontinence or some combination thereof. Furthermore, neurogenic bowel is one of the most prevalent comorbidities of SCI and is recognized by afflicted individuals and caregivers as a lifelong physical and psychological challenge that profoundly affects quality of life. Read More
Z Naturforsch C 2018 Dec 8. Epub 2018 Dec 8.
Department of Catering and Tourism, University of Food Technologies, Plovdiv, Bulgaria.
The study's objective was to investigate the volatile compounds, assess the total phenolic content and phenolic acids profile, determine the antioxidant capacity and evaluate the anthocyanin and flavonoid contents in stinging nettle (Urtica dioica L.), tansy (Tanacetum vulgare L.), bladder campion (Silene vulgaris (Moench) Garcke) and rosehip fruit (Rosa canina L. Read More
J Exp Biol 2018 Dec 10. Epub 2018 Dec 10.
Bamfield Marine Sciences Centre, 100 Pachena Road, Bamfield, BC, V0R 1B0, Canada.
Ureotelic elasmobranchs require nitrogen for both protein growth and urea-based osmoregulation, and therefore are probably nitrogen-limited in nature. Mechanisms exist for retaining and/or scavenging nitrogen at gills, kidney, rectal gland, and gut, but as yet, the latter are not well characterized. Intestinal sac preparations of the Pacific spiny dogfish shark () incubated strongly reabsorbed urea from the lumen after feeding, but mucosal fluid ammonia concentrations increased with incubation time. Read More
BMJ Open 2018 Dec 9;8(12):e023136. Epub 2018 Dec 9.
Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Objective: Ileal conduit urinary diversion (ICUD) is the most common procedure after radical cystectomy. Although complications have been reported, few patients with ICUD and bladder preservation controls have been available for long-term follow-up. This study compared the long-term effect of structural changes after cystectomy with ICUD to that in bladder preservation controls. Read More