Search Our Scientific Publications & Authors

Environ Int 2020 Jun 29;143:105857. Epub 2020 Jun 29.

CPHEA U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

This paper describes the use of multiple models and model averaging for considering dose-response uncertainties when extrapolating low-dose risk from studies of populations with high levels of exposure. The model averaging approach we applied builds upon innovative methods developed by the U.S. Read More

PLoS One 2020 2;15(7):e0229193. Epub 2020 Jul 2.

Institut für Molekulare Medizin, Universität zu Lübeck and UKSH, Lübeck, Germany.

Background: Urine-based diagnostics indicated involvement of oncoprotein 18 (OP18) in bladder cancer. In cell culture models we investigated the role of OP18 for malignant cell growth.

Methods: We analyzed 113 urine samples and investigated two human BCa cell lines as a dual model: RT-4 and ECV-304, which represented differentiated (G1) and poorly differentiated (G3) BCa. Read More

Br J Radiol 2020 Jul 2:20200197. Epub 2020 Jul 2.

Department of Radiotherapy, PGIMER, Regional Cancer Centre, Chandigarh, India.

Objective: This study presents a methodology for voxel-based evaluation of two phase sequential radiotherapy treatment plans having conventional dose scheme in the first phase and subsequent hypofractionation dose scheme in the second phase based upon different priority [planning target volume (PTV), clinical target volume (CTV) and organs at risk (OAR)] of display modes.

Methods: A case of carcinoma prostate was selected for demonstration. Varian Eclipse treatment planning system (TPS) was used for contouring and planning. Read More

Ir J Med Sci 2020 Jul 1. Epub 2020 Jul 1.

Department of Urology, University Hospital Galway, Newcastle Road, Galway, Ireland.

Introduction: Flexible cystoscopy is the gold standard for diagnosis and surveillance of bladder carcinoma. Most flexible cystoscopes feature a working channel allowing for bladder biopsy and diathermy if a suspicious lesion is observed. However, the working channel permits only small instruments which limit the volume of material retrieved for histological analysis. Read More

Pol J Radiol 2020 26;85:e261-e270. Epub 2020 May 26.

Radiology Department, National Cancer Institute Pascale Foundation, Naples, Italy.

Purpose: The incidental detection of one or more additional primary tumours during computed tomography (CT) staging of a patient with known malignancy is rare but possible. This occurrence should be considered by the radiologist when a new lesion is detected, especially if the lesion location is atypical for metastases. The purpose of this report was to document the usefulness of total body CT scan to detect synchronous primary malignancies in cancer patients undergoing a staging workup. Read More

J Oncol 2020 17;2020:7363102. Epub 2020 Jun 17.

Laboratory of Epigenetics, Research Centre for Medical Genetics, Moscow 115522, Russia.

Next generation sequencing (NGS) is widely used for diagnosing hereditary cancer syndromes. Often, exome sequencing and extended gene panel approaches are the only means that can be used to detect a pathogenic germline mutation in the case of multiple primary tumors, early onset, a family history of cancer, or a lack of specific signs associated with a particular syndrome. Certain germline mutations of oncogenes and tumor suppressor genes that determine specific clinical phenotypes may occur in mutation hot spots. Read More

Cancer Manag Res 2020 25;12:5049-5056. Epub 2020 Jun 25.

Department of Urology, Qilu Hospital of Shandong University, Jinan 250012, People's Republic of China.

Background: Increasing evidence indicates that the dysregulation of circular RNAs (circRNAs) plays important roles in tumor progressions.

Methods: In this study, we first analyzed circ-FOXO3 level in bladder cancers (BCs), and then BC cell lines were transfected with circ-FOXO3 expression vector, and cell proliferation, migration, and invasion abilities were analyzed. We also used bioinformatics tools to predict potential-binding miRNAs for circ-FOXO3, and luciferase reporter assay was used for the verification of binding miRNAs. Read More

Cells 2020 Jun 29;9(7). Epub 2020 Jun 29.

Clinical Bioinformatics Area. Fundación Progreso y Salud (FPS). CDCA, Hospital Virgen del Rocio, 41013 Sevilla, Spain.

Despite the existence of differences in gene expression across numerous genes between males and females having been known for a long time, these have been mostly ignored in many studies, including drug development and its therapeutic use. In fact, the consequences of such differences over the disease mechanisms or the drug action mechanisms are completely unknown. Here we applied mechanistic mathematical models of signaling activity to reveal the ultimate functional consequences that gender-specific gene expression activities have over cell functionality and fate. Read More

Urol Int 2020 Jul 1:1-7. Epub 2020 Jul 1.

Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China,

Introduction: The efficiency of the T1 sub-staging system on categorizing bladder cancer (BC) patients into subgroups with different clinical outcomes was unclear. We summarized relevant evidences, including recurrence-free survival (RFS), progression-free survival (PFS), and cancer-specific survival (CSS), to analyze the prognostic significance of T1 sub-stage.

Methods: Systematic literature searches of MEDLINE, EMBASE, and the Cochrane Library were performed. Read More

Eur J Pharmacol 2020 Jun 28:173312. Epub 2020 Jun 28.

Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Jiangsu Province, Nanjing, 211198, PR China; Department of Surgery, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210017, PR China; Department of Surgery, Nanjing Shuiximen Hospital, Jiangsu Province, 210017, PR China. Electronic address:

Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca homeostasis. It has been proposed to be the predominant thermoreceptor for cellular and behavioral responses to cold stimuli in the TRP channel subfamilies and exploited so far to reach the clinical-stage of drug development. Read More

Neurourol Urodyn 2020 Jul 1. Epub 2020 Jul 1.

Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

Aims: Urofacial syndrome (UFS) is an autosomal recessive disease characterized by detrusor contraction against an incompletely dilated outflow tract. This dyssynergia causes dribbling incontinence and incomplete voiding. Around half of individuals with UFS have biallelic mutations of HPSE2 that encodes heparanase 2, a protein found in pelvic ganglia and bladder nerves. Read More

Andrologia 2020 Jul 1:e13723. Epub 2020 Jul 1.

Surgery Division, Clinical Science Department, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Hookah (water pipe) smoking, an old method of tobacco smoking, is regaining widespread popularity all over the world. Although the research in this field is still deficient, it has been proven for its harmful effect on human's health by increasing the risk of cardiovascular disease, infection and lung, oral and bladder cancer (Al-Numair et al., J Food Agric Environ, 5: 17, 2007; Bou Fakhreddine et al. Read More

Ned Tijdschr Geneeskd 2020 Jun 25;164. Epub 2020 Jun 25.

Radboudumc, afd. Heelkunde,Nijmegen.

Preoperative chemotherapy followed by surgery was applied in three patients, aged 68 years (male), 48 years (female), and 80 years (male) with locally advanced cancer of the colon with bladder invasion. Achieving a resection with free margins (R0) is essential in colon-cancer surgery, but the role of preoperative chemotherapy in colon cancer remains unknown. When a tumour is presumed to be unresectable, guidelines recommend discussing the case and possibly referring the patient to an oncological expertise centre, where each patient will be individually assessed for the most suitable preoperative treatment and surgery during a multidisciplinary tumour board meeting. Read More

Yonsei Med J 2020 Jul;61(7):587-596

Department of Medicine, Graduate School of Yonsei University College of Medicine, Seoul, Korea.

Purpose: The current study aimed to investigate the synergistic antitumor effect of combined treatment with 17-DMAG (HSP90 inhibitor) and NVP-BEZ235 (PI3K/mTOR dual inhibitor) on cisplatin-resistant human bladder cancer cells.

Materials And Methods: Human bladder cancer cells exhibiting cisplatin resistance (T24R2) were exposed to escalating doses of 17-DMAG (2.5-20 nM) with or without NVP-BEZ236 (0. Read More

Biomed Microdevices 2020 Jun 30;22(3):45. Epub 2020 Jun 30.

Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan.

Galectin-1 protein has been recently recognized as a valuable urinary biomarker for the diagnosis and prognosis of bladder cancer. Herein, we present a sensitive and specific impedimetric immunosensor for the quantitative and label free detection of Galectin-1 protein in clinical urine samples. The immunosensor consists of nine gold interdigitated microelectrodes (3 × 3 array), which can simultaneously monitor multiple immunoreactions by analyzing the normalized impedance variations at each microelectrode during immunosensing. Read More

Cancer Cell Int 2020 26;20:276. Epub 2020 Jun 26.

Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050 China.

Background: As bladder cancer was recognized to be immunogenic, dozens of studies have focused on immune biology of BLCA, but little is known about its relationship with the long non-coding RNAs (lncRNAs).

Methods: LASSO Cox regression model was used to establish immune-related lncRNAs signature (IRLS) in BLCA. The immune infiltration landscape of BLCA was conducted via ssGSEA and immunotherapy response was calculated through TIDE algorithm. Read More

Eur Urol Oncol 2020 Jun 27. Epub 2020 Jun 27.

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. Electronic address:

Interim data from the PURE-01 study, using pembrolizumab before radical cystectomy in muscle-invasive bladder cancer (MIBC), suggested that multiparametric magnetic resonance imaging (mpMRI) was able to predict the pathologic response. Owing to the availability of novel effective therapies in MIBC, the possibility to assess tumor response easily has become exceedingly important. The primary objective of the present study was to evaluate the association between individual and combined MRI sequences, and the pathologic response in the final PURE-01 population. Read More

Cancers (Basel) 2020 Jun 28;12(7). Epub 2020 Jun 28.

Laboratory for Cancer Research, School of Medicine, University of Split, 21000 Split, Croatia.

Urinary bladder cancer is one of the leading malignancies worldwide, with the highest recurrence rates. A diet rich in vitamin A has proven to lower the risk of cancer, yet the molecular mechanisms underlying this effect are unknown. We found that vitamin A decreased urothelial atypia and apoptosis during early bladder carcinogenesis induced by -butyl--(4-hydroxybutyl) nitrosamine (BBN). Read More

Biomedicines 2020 Jun 27;8(7). Epub 2020 Jun 27.

Department of Functional Molecular Kinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.

We previously showed that ergosterol has an inhibitory effect on bladder carcinogenesis. In this study, we aimed to elucidate the molecular mechanism by which ergosterol inhibits bladder carcinogenesis using a rat model of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder cancer. The messenger ribonucleic acid (mRNA) expression level of the cell cycle-related gene cyclin D1 and inflammation-related gene cyclooxygenase-2 in bladder epithelial cells was significantly increased in the carcinogenesis group compared with the control group. Read More

Urology 2020 Jun 27. Epub 2020 Jun 27.

Department of Urologic Oncology, University of Michigan, Ann Arbor, MI.

Anal Chem 2020 Jun 30. Epub 2020 Jun 30.

Nanozymes have been used in colorimetric and electrochemical sensing because of their low cost and high stability. However, the wide applications of nanozymes in sensing devices are largely limited due to their poor selectivity. In this study, unlike traditional methods using prepared nanozymes for target detection, we designed a target-driven nanozyme growth strategy in TiO na-nochannels to detect analytes. Read More

J Urol 2020 Jun 30:101097JU0000000000001175. Epub 2020 Jun 30.

J Urol 2020 Jun 30:101097JU000000000000117501. Epub 2020 Jun 30.

PM R 2020 Jun 30. Epub 2020 Jun 30.

Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

J Robot Surg 2020 Jun 29. Epub 2020 Jun 29.

Department of Urology, Karolinska University Hospital, Stockholm, Sweden.

A posterior reconstruction (PR) might improve the fluidity and delicacy of the maneuvers related to the neovesico-urethral anastomosis during robotic-assisted radical cystectomy (RARC). Our objective is to describe in detail the surgical steps of PR and to assess its feasibility and functional outcomes. The data regarding patients undergoing a totally intracorporeal RARC with neobladder and PR for high-grade and/or muscle-invasive urothelial cancer of the bladder at Karolinska University Hospital between October 2015 and November 2016 by a single surgeon (PW) were reviewed. Read More

Updates Surg 2020 Jun 29. Epub 2020 Jun 29.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Sarcoma Center, Peking University Cancer Hospital and Institute, #52 Fu-Cheng-Lu Street, Hai-Dian District, Beijing, 100142, China.

Complete resection for retroperitoneal sarcoma (RPS) involving major vessels frequently requires vascular resection and reconstruction. The use of artificial grafts often leads to postoperative vascular graft infection (VGI), which usually requires reoperation and sometimes leads to death. In the present study, the data of RPS patients who underwent contralateral iliac artery (IIA) transposition for reconstruction of the common iliac artery (CIA) after RPS resection from 2015-2019 were retrospectively analyzed. Read More

Curr Treat Options Oncol 2020 Jun 29;21(8):63. Epub 2020 Jun 29.

University of Arizona Cancer Center, 1400 Holcombe Blvd Unit 463, Tucson, AZ, 77030, USA.

Opinion Statement: The standard of care first-line therapy for patients with advanced biliary tract cancers eligible for treatment continues to be the combination of gemcitabine and cisplatin. Based on the promising results of a phase II study, an ongoing multi-institutional phase III study is assessing the benefit of adding nab-paclitaxel to the chemotherapy doublet, and appropriate patients should be considered for enrollment at participating centers. We would recommend early comprehensive genomic profiling of patients' tumors to identify potentially targetable aberrations with available therapies. Read More

Eur Radiol 2020 Jun 29. Epub 2020 Jun 29.

Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuaifuyuan No. 1, Wangfujing Street, Dongcheng District, Beijing, 100730, China.

Objective: To build a CT-based radiomics model to predict the pathological grade of bladder cancer (BCa) preliminarily.

Methods: Patients with surgically resected and pathologically confirmed BCa and who received CT urography (CTU) in our institution from October 2014 to September 2017 were retrospectively enrolled and randomly divided into training and validation groups. After feature extraction, we calculated the linear dependent coefficient between features to eliminate the collinearity. Read More

Spinal Cord Ser Cases 2020 Jun 29;6(1):55. Epub 2020 Jun 29.

Centre for Spinal Cord Injuries, BG Klinikum Hamburg, Hamburg, Germany.

Study Design: Retrospective descriptive study.

Objectives: To compare histopathological findings and the long-term course of SCI patients with bladder cancer found incidentally at the initial urological workup to those diagnosed with bladder cancer many years after the onset of SCI.

Setting: Spinal cord injury center in Germany. Read More

Urol Oncol 2020 Jun 27. Epub 2020 Jun 27.

Department of Urology, Seattle Cancer Care Alliance, University of Washington, Seattle, WA. Electronic address:

Actas Urol Esp 2020 Jun 26. Epub 2020 Jun 26.

Servicio de Urología, Consorci Corporació Sanitària Parc Taulí, Sabadell, Barcelona, España.

Objective: To evaluate the prevalence of preoperative anemia and its effect on oncological outcomes in patients undergoing radical cystectomy (RC) due to bladder cancer.

Material And Methods: Retrospective single-center study with 176 RCs between May 2008 and July 2018. Anemia was defined according to the WHO classification (male<130mg/dL, female<120mg/dL). Read More

J Endourol 2020 Jun 29. Epub 2020 Jun 29.

Spire Roding, Urology, Roding Lane South, London, United Kingdom of Great Britain and Northern Ireland, IG4 5PZ;

Introduction This exploratory retrospective analysis examined any potential prognostic role of pre-operative NLR for progression free survival (PFS) and time to endoscopically verified upper tract or bladder recurrence free survival (RFS), in upper tract urothelial cancer (UTUC) patients selected for endoscopic treatment with subsequent endo-surveillance. Patients and Methods Eligibility criteria were natural orifice endoscopically retrogradely treated low-risk and imperative UTUC patients treated between 2005-2019, with biopsy confirmed diagnosis and 12 months minimum follow-up. For PFS, optimal NLR cut-off value was derived by log-rank test. Read More

Int J Mol Sci 2020 Jun 24;21(12). Epub 2020 Jun 24.

Department of Genetics, Maria Sklodowska-Curie Institute-Oncology Center, 02-781 Warsaw, Poland.

Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Read More

Crit Rev Oncol Hematol 2020 Jun 15;153:103032. Epub 2020 Jun 15.

Department of Oncology, Affiliated Hospital of Weifang Medical University, 261031, Weifang, China. Electronic address:

Objective: Numerous studies have reported that patients with cancer seem to be more likely to be diagnosed with COVID-19. However, it is still unknown the prevalence of different types of cancer in patients with COVID-19. Therefore, this study will explore which type of cancer patients are more susceptible to the SARS-COX-2. Read More

Pract Radiat Oncol 2020 Jun 26. Epub 2020 Jun 26.

Royal Victoria Regional Health Centre, 201 Georgian Dr, Barrie, ON, Canada, L4M 6M2. Electronic address:

Purpose: Auto-contouring may reduce workload, inter-observer variation and time associated with manual contouring of organs at risk (OAR). Manual contouring remains the standard due in part to uncertainty around the time and workload savings after accounting for the review and editing of auto-contours. This preliminary study compares a standard manual contouring workflow with two auto-contouring workflows (atlas and deep learning) for contouring the bladder and rectum in prostate cancer patients. Read More

Rev Recent Clin Trials 2020 Jun 28. Epub 2020 Jun 28.

Department of Precision Medicine, University of Campania Luigi Vanvitelli, NA. Italy.

Background: In accordance with the scientific literature heavy alcohol consumption (>50g per day) represents a risk factor for several diseases development, including cancer. However, the oncogenic role of light alcohol drinking (<12,5g per day) is still unknown.

Objective: To assess the scientific knowledge about light alcohol consumption and the risk of malignancy onset. Read More

Cancer Biother Radiopharm 2020 Jun 27. Epub 2020 Jun 27.

Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, China.

LncRNA ELF3-AS1 has been characterized as an oncogenic lncRNA in bladder cancer and oral cancer, whereas its role in nonsmall cell lung cancer (NSCLC) is unknown. In this study, the authors observed that ELF3-AS1 was upregulated in NSCLC tissues in comparison with that in paired nontumor tissues collected from 68 NSCLC patients. High expression levels of ELF3-AS1 predicted the poor survival of NSCLC patients. Read More

J Endourol 2020 Jun 27. Epub 2020 Jun 27.

Institut Mutualiste Montsouris, 26953, Urology, Paris, Île-de-France, France;

Background: Minimally invasive cystectomy is being increasingly performed however, data comparing laparoscopic radical cystectomy (LRC) and robotic radical cystectomy (RRC) is scarce. We compared 30-day and 90-day Clavien-Dindo Classification(CDC) complications between patients undergoing LRC and RRC at our centre.

Materials And Methods: We retrospectively evaluated 300 patients who underwent minimally invasive radical cystectomy from January 2007 to July 2019 and grouped them into LRC (112 patients) and RRC (188 patients). Read More

J Cell Mol Med 2020 Jun 28. Epub 2020 Jun 28.

Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Growing evidence suggests that long non-coding RNAs (lncRNAs) are associated with carcinogenesis. LncRNA small nucleolar RNA host gene 3 (SNHG3) is up-regulated in various cancers and positively associated with poor prognosis of these cancers. However, the precise role of lncRNA SNHG3 in bladder cancer (Bca) remains unclear. Read More

FASEB J 2020 Jun 28. Epub 2020 Jun 28.

Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Clinical College of Anhui Medical University, Shenzhen, China.

Although renal cell carcinoma (RCC) is a common malignant urological cancer, its pathogenesis remains unclear. Previous studies have indicated that miR-140-5p acts as a tumor suppressor in various tumors, including bladder cancer, hepatocellular carcinoma, and gastric cancer, but its biological function in RCC remains unknown. In the present study, we found that miR-140-5p was upregulated in RCC tissues, whereas Krüppel-like factor 9 (KLF9) was downregulated and correlated inversely with miR-140-5p in RCC tissues. Read More

J Cell Mol Med 2020 Jun 28. Epub 2020 Jun 28.

Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

MiR-146a-5p in urine samples was recently reported to be possibly used as a prognostic marker for bladder cancer (BC). Interestingly, YAP1 and COX2 were both demonstrated to function as stem cell regulators in BC. Therefore, in this study, we aimed to establish the molecular mechanism underlying the role of miR-146a, YAP1 and COX2 in BC relapse. Read More

JNCI Cancer Spectr 2020 Jun 12;4(3):pkaa021. Epub 2020 Mar 12.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: Genome-wide association studies have identified common genetic risk variants in many loci associated with multiple cancers. We sought to systematically evaluate the utility of these risk variants in identifying high-risk individuals for eight common cancers.

Methods: We constructed polygenic risk scores (PRS) using genome-wide association studies-identified risk variants for each cancer. Read More

Biomed Res Int 2020 4;2020:9186546. Epub 2020 Jun 4.

College of Computer Science and Technology, Jilin University, Changchun, Jilin, China.

Bladder cancer (BLCA) is the fourth common cancer among males in the United States, which is also the fourth leading cause of cancer-related death in old males. BLCA has a high recurrence rate, with over 50% of patients which has at least one recurrence within five years. Due to the complexity of the molecular mechanisms and heterogeneous cancer feature, BLCA clinicians find it hard to make an efficient management decision as they lack reliable assessment of mortality risk. Read More

Biomed Res Int 2020 3;2020:5658904. Epub 2020 Jun 3.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Clinical trials based on FGFR mutation or amplification as a druggable target of FGFR inhibitors have produced disappointing clinical outcomes. Therefore, the identification of predictive biomarkers for FGFR-targeted agents has remained a crucial issue.

Methods: Expression profiles of FGFs and FGFRs in 8,111 patients with 24 types of solid tumors and 879 tumor cell lines along with drug sensitivity data were obtained and followed by integrative bioinformatics analysis. Read More

Front Oncol 2020 12;10:957. Epub 2020 Jun 12.

Department of Biochemistry and Molecular Biology, Institute of Glycobiology, Dalian Medical University, Dalian, China.

Bladder cancer is one of the most common malignant tumors of the urogenital system with high morbidity and mortality worldwide. Early diagnosis and personalized treatment are the keys to successful bladder cancer treatment. Due to high postoperative recurrence rates and poor prognosis, it is urgent to find suitable therapeutic targets and biomarkers. Read More

J Surg Case Rep 2020 Jun 19;2020(6):rjaa064. Epub 2020 Jun 19.

General Surgery Residency, Hospital Episcopal San Lucas, Ponce, Puerto Rico.

This is an unusual case report of 32-year-old Hispanic male who presented with an early-onset advanced stage colorectal cancer with an enterovesical fistula. A 32-year-old man presented to our institution referring suprapubic pain, urinary frequency, dysuria and tenesmus for several weeks suggesting Gouverneur's syndrome. Patient had been treated with oral antibiotics for his recurrent urinary tract infections without resolution. Read More

BMJ Case Rep 2020 Jun 28;13(6). Epub 2020 Jun 28.

Department of Cellular Pathology, Royal Free London NHS Foundation Trust, London, UK.

Synovial metastasis is a rare presentation with only a few reported cases in the published literature. A majority of cases of malignant synovitis have a primary lung or colorectal origin. It carries a poor prognosis with an average survival of approximately 5 months from diagnosis. Read More

Immunotherapy 2020 Jun 29. Epub 2020 Jun 29.

GU Medical Oncology, Inova Schar Cancer Institute, Fairfax, VA, USA.

Immune checkpoint inhibitor (ICI) therapy and therapeutic cancer vaccines have continued to demonstrate survival benefit and durable clinical response in patients with renal cell cancer, prostate cancer and bladder cancer, with limited responses in testicular cancer. The role of immunotherapy in combination with chemotherapy or other targeted therapies in the neo-adjuvant, adjuvant and metastatic setting is actively being explored. We describe the current immunotherapy-related treatment modalities approved for genitourinary cancers, focusing on immune checkpoint inhibitors, vaccines and other modalities, and highlight ongoing studies involving immunotherapy in these cancer types. Read More

Med Phys 2020 Jun 27. Epub 2020 Jun 27.

Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Purpose: To generate a series of physiologically plausible cervix CTVs by biomechanically modeling organ deformation as a consequence of bladder filling. This series can serve as planning CTVs for radiotherapy treatment of cervical cancer patients using a library of plans (LoP) strategy.

Methods: The model was constructed based on the full and empty bladder scans of 20 cervical cancer patients, for which the bladder, cervix, uterus and rectum were delineated. Read More

Eur Urol 2020 Jun 24. Epub 2020 Jun 24.

Department of Urology, Hospital Motol, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Urology Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria; Department of Urology, Weill Cornell Medical College, New York, NY, USA; Department of Urology, University of Texas Southwestern, Dallas, TX, USA; Institute for Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Context: The European Association of Urology (EAU) Guidelines Panel on Upper Urinary Tract Urothelial Carcinoma (UTUC) has prepared updated guidelines to aid clinicians in the current evidence-based management of UTUC and to incorporate recommendations into clinical practice.

Objective: To provide an overview of the EAU guidelines on UTUC as an aid to clinicians.

Evidence Acquisition: The recommendations provided in the current guidelines are based on a thorough review of available UTUC guidelines and articles identified following a systematic search of Medline. Read More