Search Our Scientific Publications & Authors

Drug Resist Updat 2019 Apr 9;43:10-28. Epub 2019 Apr 9.

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, United States. Electronic address:

Recent advances in the treatment of various cancers have resulted in the adaptation of several novel immunotherapeutic strategies. Notably, the recent intervention through immune checkpoint inhibitors has resulted in significant clinical responses and prolongation of survival in patients with several therapy-resistant cancers (melanoma, lung, bladder, etc.). Read More

Urol J 2019 Apr 20. Epub 2019 Apr 20.

Department of Urology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Purpose: Biochemical failure after radical prostatectomy has been defined based on retrospective studies in men who underwent RP for localized prostate cancer. Nevertheless, retrospective strategy and possibility of extra-prostatic extension overshadowed the accurateness of the aforementioned cut-off value. To define a more precise PSA nadir value, we estimated serum PSA after cystoprostatectomy in cases with bladder urothelial cancer and no evidence of prostate cancer. Read More

Bioorg Chem 2019 Apr 11;88:102925. Epub 2019 Apr 11.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India. Electronic address:

Cisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways which finally lead to apoptosis. However, side effects and drug resistance are the two inherent challenges of cisplatin which limit its application and effectiveness. Read More

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Chirurgie Cancérologique Gynécologique et du Sein, Paris, France; Université Paris Descartes, INSERM UMR-S 747, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France. Electronic address:

Objectives: Lynch syndrome (LS) is a hereditary predisposition to cancers, first of all, colo-rectal and endometrial cancers in women. Although recommended, gynecologic screening has never proven its benefit. Prophylactic surgery can be consider once the parental project is completed. Read More

Gene 2019 Apr 16. Epub 2019 Apr 16.

Department of Ultrasonography, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China. Electronic address:

Background: Chronic inflammatory microenvironment has been shown to play a key role in initiating tumorigenesis and facilitating malignant progression. Primary tumors surrounded with and infiltrated by tumor-associated macrophages (TAMs) significantly promote the epithelial-to-mesenchymal transition (EMT) and distant metastasis in urothelial bladder cancer.

Methods: In this study, we aimed to explore the potential of targeting TAMs for the treatment of malignant bladder cancer. Read More

Exp Cell Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastrointestinal Surgery, Qingyuan People's Hospital, The Six Affiliated Hosptial of Guangzhou Medical University, Qingyuan City, 511518, China. Electronic address:

CSTP1, a recently identified protein phosphotase, is frequently repressed in bladder cancers. Previous results showed that CSTP1 over-expression inhibited cell cycle progression and promoted apoptosis through dephosphorylating Akt kinase at Ser473 site in bladder cancer cells, but the mechanisms how CSTP1 exerted tumor suppressive activity remains unclear. In this study, we analyzed the gene expression profile changes that affected by CSTP1 overexpression by microarray, and reported that CSTP1 decreased IL-6 expression/secretion in bladder cancer cells and re-expression of IL-6 abrogated CSTP1's tumor suppressive activity. Read More

PLoS One 2019 19;14(4):e0215770. Epub 2019 Apr 19.

Departments of Medicine and Biochemistry & the Stony Brook Cancer Center at Stony Brook University, Stony Brook, New York, United States of America.

The purpose of this study was to determine the profile of bioactive sphingolipids in xenograft mouse tissues of head and neck squamous cell carcinoma. We utilized UHPLC-MS/MS to determine the profile of full set of ceramides, sphingosine, and sphingosine 1-phosphate in this xenograft mouse model. The tissues isolated and investigated were from brain, lung, heart, liver, spleen, kidney, bladder, tumors and blood. Read More

Clin Exp Pharmacol Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Acibadem University, İstanbul, Turkey.

In this review article, we hypothesize that Hepatitis B Virus Vaccine (HBV-V) and certain antigens of Hepatitis B Virus (HBV)-could act as anticancer immunoadjuvants in addition to their role of preventing HBV-associated liver cancer. Evidence suggests that in animal breast cancer and melanoma models, combining hepatitis B-surface antigen (HBsAg) with other cancer antigens resulted in enhanced antitumor activity. HBsAg shares antigenic mimicry with healthy and malignant cells including squamous epithelia, thymic epithelia, bladder- and colon cancer cells. Read More

Front Genet 2019 2;10:270. Epub 2019 Apr 2.

Division of Biomedical Engineering, University of Saskatchewan Saskatoon, SK Canada.

Complex diseases are known to be associated with disease genes. Uncovering disease-gene associations is critical for diagnosis, treatment, and prevention of diseases. Computational algorithms which effectively predict candidate disease-gene associations prior to experimental proof can greatly reduce the associated cost and time. Read More

Indian J Radiol Imaging 2019 Jan-Mar;29(1):40-46

Department of Liver Transplantation and Hepato Pancreatico Biliary Surgery, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, India.

Aims And Objectives: To evaluate the outcome of preoperative portal vein embolization (PVE) using N-butyl cyanoacrylate (NBCA) for change in future liver remnant (FLR) volume, biochemical changes, and procedure-related complications. The factors affecting FLR hypertrophy and the rate of resection was also evaluated for this cohort.

Materials And Methods: From 2012 to 2017, PVE utilizing NBCA mixed with lipiodol (1:4) was performed using percutaneous approach in 28 patients with hepatobiliary malignancies with low FLR. Read More

Indian J Urol 2019 Apr-Jun;35(2):121-128

Department of Urology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Introduction: We present the short-term voiding patterns and functional and urodynamic outcomes of W-shaped ileal orthotopic neobladder (ONB) following radical cystectomy (RC).

Materials And Methods: Forty-one patients who underwent RC and W-shaped ONB creation between July 2015 and January 2018 were enrolled. Data were analyzed in terms of voiding patterns, urodynamic findings, and functional outcomes at 6 months after surgery. Read More

Cancer Commun (Lond) 2019 Apr 18;39(1):19. Epub 2019 Apr 18.

Department of Urology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, P. R. China.

Background: Radical cystectomy and urinary diversion remains the standard surgical treatment for patients with muscle-invasive or high-risk or recurrent non-muscle-invasive bladder cancer. Although this approach prolongs patient survival remarkably, there are postoperative complications associated with urinary diversion. This study aimed to assess the efficacy of modified ileal conduit surgery for reducing early and late stoma- and ureteroileal anastomosis-related complications, as compared with conventional ileal conduit urinary diversion. Read More

J Exp Clin Cancer Res 2019 Apr 18;38(1):169. Epub 2019 Apr 18.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China.

Background: FGFR3 plays an important role in the development of bladder cancer (BCa). Hsa_circ_0068871 is a circRNA generated from several exons of FGFR3. However, the potential functional role of hsa_circ_0068871 in BCa remains largely unknown. Read More

BMC Infect Dis 2019 Apr 18;19(1):331. Epub 2019 Apr 18.

Department of Medical Microbiology and Immunology, University of California - Davis, University of California Davis Medical Center, Sacramento, CA, USA.

Background: Prosthetic joint infections remain a significant cause of morbidity and are frustrating for patients and physicians alike. Unusual causes of infection may be seen in selected circumstances and a high index of suspicion and a careful history are required to ensure an accurate and timely diagnosis can be made.

Case Presentation: We present a case of Mycobacterium bovis prosthetic joint infection secondary to intravesicular Bacillus Calmette-Guérin (BCG) treatment for prior bladder cancer definitively identified by spoligotyping. Read More

BMC Urol 2019 Apr 18;19(1):24. Epub 2019 Apr 18.

Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Background: To investigate the prognostic risk factors and postoperative recurrence of bladder cancer in patients with upper urinary tract urothelial carcinomas (UTUCs).

Methods: Data of 439 UTUC patients were retrospectively analyzed. Follow-up and analysis of smoking effects, consumption of traditional Chinese medicine containing aristolochic acid, history of bladder cancer, age, sex, presence or absence of diabetes mellitus (DM), metformin use, tumor characteristics (number, location, stage, grade), and open or laparoscopic surgery on the prognosis of UTUCs were performed. Read More

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

H Reis, Institute of Pathology , University of Essen-Duisburg, Essen, Germany.

Recently, a neuroendocrine-like molecular subtype has been discovered in muscle-invasive urothelial bladder cancer (BC). Chromogranin A (CGA) is a widely used tissue and serum marker in neuroendocrine tumors. Our aim was to evaluate serum CGA (sCGA) concentrations and their associations with clinical and follow-up data in BC and renal cell carcinoma (RCC). Read More

IEEE J Biomed Health Inform 2019 Apr 16. Epub 2019 Apr 16.

Systematic identification of miRNA prognostic signature can help decipher the effects of biomarkers in cancer treatment. A number of previous studies have only characterized a single miRNA as a promising prognostic biomarker. There is currently a trend towards combining several miRNAs as a panel of prognostic signatures, but few attempt to explain the mechanism of miRNA combination. Read More

Cancer Immunol Immunother 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Objectives: Advanced age and female sex have been associated with worse outcomes in patients undergoing radical cystectomy for muscle-invasive bladder cancer. A reduced immune response has been implicated as a mechanism. The objective of our study was to analyze the expression patterns of various cellular proteins active in bladder cancer immune pathways, and assess the correlation between age, sex, and the expression of these immune markers. Read More

J Transl Int Med 2019 Mar 29;7(1):29-33. Epub 2019 Mar 29.

Department of Urology, School of Medicine, University of Thessaly, Larissa, Greece.

Liver cirrhosis is a major risk factor for increased mortality and morbidity in patients undergoing non-hepatic surgery with overall mortality rates as high as 45-50%. However, cirrhotic patients are often in need of surgical procedures including urological surgeries like cystectomies for muscle invasive bladder cancer. Data on the prognosis of these patients undergoing cystectomy for bladder cancer are scarce in the literature. Read More

Chin J Cancer Res 2019 Feb;31(1):49-66

Cancer Res 2019 Apr 17. Epub 2019 Apr 17.

Computational Medicine Center, Thomas Jefferson University

tRNA-derived fragments (tRFs) are a class of potent regulatory RNAs. We mined the datasets from The Cancer Genome Atlas representing 32 cancer types with a deterministic and exhaustive pipeline for tRNA fragments. We found that mitochondrial tRNAs contribute disproportionally more tRFs than the nuclear ones. Read More

AJR Am J Roentgenol 2019 Apr 17:1-8. Epub 2019 Apr 17.

1 Department of Radiology, Amiens University Hospital, Ave Rene Laennec, Amiens, France 80054.

The purpose of this study was to evaluate whether dual-energy CT follow-up of kidney transplant recipients performed with only two contrast-enhanced phases and reconstructed material maps has the same diagnostic efficiency as triphasic conventional CT in detection and characterization of atypical renal cysts and renal masses. In a retrospective study, 175 renal transplant patients underwent dual-energy CT as part of their follow-up (monoenergetic unenhanced, late contrast-enhanced, and tubular contrast-enhanced dual-energy phases). An unenhanced virtual series and material separation maps were reconstructed. Read More

Colorectal Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands.

Introduction: Patients undergoing resectional surgery for enterovesical fistulas generally have an in-dwelling urinary catheter postoperatively to prevent a recurrent fistula. The aim of this study was to assess the place of a postoperative cystogram after such surgery, when it should be performed and for how long the bladder should be drained after surgery.

Methods: A retrospective single centre study of all patients undergoing ileocaecal or sigmoid resection for surgery for enterovesical fistula with the primary endpoint of recurrent urinary fistula. Read More

World J Urol 2019 Apr 16. Epub 2019 Apr 16.

Department of Urology and Renal Transplantation, La Conception University Hospital, APHM, Aix-Marseille University, 13005, Marseille, France.

Purpose: There have recent reports in the literature of increased rates of bladder recurrence (BR) after radical nephroureterectomy (RNU) when diagnostic flexible ureteroscopy (DFU) was performed before RNU. The technical heterogeneity of DFU was a major bias in these studies. Our purpose was to evaluate the impact of a standardized DFU technique before RNU on the risk of BR. Read More

World J Urol 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.

Background: Basophils, eosinophils and monocytes may be involved in BCG-induced immune responses and be associated with outcomes of bladder cancer patients receiving intravesical BCG. Our objective was to explore the association of baseline counts of basophils, eosinophils and monocytes with outcomes of patients with high-grade T1 bladder cancer receiving a standard course of intravesical BCG.

Methods: We retrospectively reviewed medical records of patients with primary T1 HG/G3 bladder cancer. Read More

World J Surg 2019 Apr 16. Epub 2019 Apr 16.

Colorectal Cancer Unit, Department of Surgery, Zealand University Hospital, Roskilde, Sygehusvej 10, 4000, Roskilde, Denmark.

Background: Early catheter removal is essential to enhance postoperative mobilization and recovery, but may carry a risk of urinary retention. This study aimed to evaluate a standardized regimen for early postoperative catheter removal and re-catheterization in patients undergoing elective laparoscopic colorectal cancer surgery within an optimal ERAS setting.

Methods: This was a single-center prospective study of patients undergoing elective minimally invasive colorectal resection and postoperative catheter removal within 24 h, with a re-catheterization threshold of 800 ml bladder volume. Read More

NPJ Precis Oncol 2019 15;3:11. Epub 2019 Apr 15.

Biocruces-Bizkaia Health Research Institute, Barakaldo, Spain.

Anti-PTEN monoclonal antibodies (mAb) are arising as important tools for immunohistochemistry (IHC) and protein quantification routine analysis in clinical oncology. Although an effort has been made to document the reliability of tumor tissue section immunostaining by anti-PTEN mAb, and to standardize their IHC use in research and in the clinical practice, the precise topological and biochemical definition of the epitope recognized by each mAb has been conventionally overlooked. In this study, six commercial anti-PTEN mAb have been validated and characterized for sensitivity and specificity by IHC and FISH, using a set of prostate and urothelial bladder tumor specimens, and by immunoblot, using PTEN positive and PTEN negative human cell lines. Read More

Cell Death Discov 2019 11;5:87. Epub 2019 Apr 11.

3Cancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), PO Box 34110, Doha, Qatar.

The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tumor cells. In the current study, we observed that several cancer cell lines, e. Read More

Mol Cancer Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Indiana University School of Medicine

Functional modeling of normal breast epithelial hierarchy and stromal-epithelial cell interactions have been difficult due to inability to obtain sufficient stem-progenitor-mature epithelial and stromal cells. Recently reported epithelial reprogramming assay has partially overcome this limitation, but cross contamination of cells from the feeder layer is a concern. The purpose of this study was to develop a feeder-layer independent inexpensive method to propagate multiple cell types from limited tissue resources. Read More

J Clin Med 2019 Apr 15;8(4). Epub 2019 Apr 15.

Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea.

C1QBP (Complement Component 1 Q Subcomponent-Binding Protein), a multicompartmental protein, participates in various cellular processes, including mRNA splicing, ribosome biogenesis, protein synthesis in mitochondria, apoptosis, transcriptional regulation, and infection processes of viruses. The correlation of C1QBP expression with patient survival and molecular function of C1QBP in relation to cancer progression has not been comprehensively studied. Therefore, we sought to systematically investigate the expression of C1QBP to evaluate the change of C1QBP expression and the relationship with patient survival and affected pathways in breast, lung, colon, and bladder cancers as well as lymphoma. Read More

Eur J Cancer Care (Engl) 2019 Apr 16:e13039. Epub 2019 Apr 16.

School of Nursing and Midwifery, Oxford Brookes University, Oxford, UK.

Objective: Written information can be an essential source of support in the promotion of lifestyle changes after a cancer diagnosis. This study aimed to identify and assess the quality of available online patient information materials (PIMs) in relation to diet and nutrition for patients with pelvic cancer.

Methods: The online sources of the National Health Service, cancer centres and charitable organisations throughout the UK were searched. Read More

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(4):803-810

College of Chinese Medicine,School of Traditional Chinese Pharmacy,China Pharmaceutical University Nanjing 211198,China.

To mine and discover the active components of " Coptidis Rhizome-Magnoliae Officinalis Cortex( C&M) " based on the network pharmacology,integrate and analyze the potential targets and mechanisms. The TCMSP database was used to screen active ingredients. TTD and Drug Bank databases were used to predict the potential targets by referring to relevant literature,and the pathway annotation technology was used to enrich and analyze the active ingredients and potential targets of " C&M". Read More

Oncol Lett 2019 May 12;17(5):4437-4442. Epub 2019 Mar 12.

Department of Emergency, Hunan Provincial People's Hospital, Changsha, Hunan 410005, P.R. China.

Changes in the expression of miR-490-5p, miR-148a-3p and miR-608 in bladder cancer tissues were studied. A total of 30 patients with bladder cancer who had surgical resection in the Hunan Provincial People's Hospital (Changsha, China) from April 2015 to August 2016 were selected. RT-qPCR was used to detect the expression levels of miR-490-5p, miR-148a-3p and miR-608. Read More

Exp Ther Med 2019 May 18;17(5):4273-4278. Epub 2019 Mar 18.

Department of Urology Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei College of Arts and Sciences, Xiangyang, Hubei 441021, P.R. China.

MicroRNAs (miRs) are widely involved in regulating tumor development and progression. miR-758-3p has been reported to suppress the progression of various cancer types, including hepatocellular carcinoma. However, whether miR-758-3p has a role in bladder cancer (BC) has not been previously reported, and was thus investigated in the present study. Read More

Exp Ther Med 2019 May 20;17(5):4213-4222. Epub 2019 Mar 20.

Center for Cell Therapy, Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan R.O.C.

Bladder cancer is one of the most common types of malignant tumor worldwide. Current treatments, including chemo-/radiotherapy, only have limited efficacy on bladder cancer progression. Honokiol is an active component of with multiple biological effects that may provide promising health benefits. Read More

Clin Chem 2019 Apr 15. Epub 2019 Apr 15.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong

Background: The current diagnosis and monitoring of bladder cancer are heavily reliant on cystoscopy, an invasive and costly procedure. Previous efforts in urine-based detection of bladder cancer focused on targeted approaches that are predicated on the tumor expressing specific aberrations. We aimed to noninvasively detect bladder cancer by the genome-wide assessment of methylomic and copy number aberrations (CNAs). Read More

Clin Cancer Res 2019 Apr 15. Epub 2019 Apr 15.

Medical Oncology, Georgetown University

Background: NRG1 gene fusions are rare but potentially actionable oncogenic drivers present in some solid tumors. Details regarding the incidence of these gene rearrangements are lacking. Here, we assessed the incidence of NRG1 fusions across multiple tumor types and described fusion partners. Read More

Cancer Immunol Res 2019 Apr 15. Epub 2019 Apr 15.

Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg

Muscle-invasive bladder cancer (MIBC) represents approximately two-thirds of invasive urothelial bladder cancers (UBCs) and has high morbidity and mortality. Men are over 3-fold more frequently affected by UBC than women. Despite intensive efforts to improve patient treatment and outcome, two-thirds of patients with UBC will have a recurrence or disease progression within 5 years. Read More

Eur Urol 2019 Apr 12. Epub 2019 Apr 12.

Division of Urology, Department of Surgical Sciences, San Giovanni Battista Hospital, University of Studies of Torino, Turin, Italy. Electronic address:

J Food Drug Anal 2019 Apr 7;27(2):460-474. Epub 2019 Jan 7.

Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Liver Research Center, Chang Gung Memorial Hospital at Linkou, Gueishan, Taoyuan, 33305, Taiwan; Department of Cell and Molecular Biology, Chang Gung University, Guishan, Taoyuan, 33302, Taiwan; Research Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.

Metabolomics is considered an effective approach for understanding metabolic responses in complex biological systems. Accordingly, it has attracted increasing attention for biomarker discovery, especially in cancer. In this study, we used a non-invasive method to evaluate four urine metabolite biomarker candidates-o-phosphoethanolamine, 3-amio-2-piperidone, uridine and 5-hydroxyindoleactic acid-for their potential as bladder cancer diagnostic biomarkers. Read More

J Food Drug Anal 2019 Apr 27;27(2):387-403. Epub 2018 Oct 27.

Division of Urology, Department of Surgery, LinKou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Prostate, bladder and kidney cancer are the three most common types of genitourinary cancer in the world. Of these, prostate and bladder cancers are within the top 10 most common cancers in men. Notably, kidney cancer causes no obvious symptoms in the early stages. Read More

Technol Cancer Res Treat 2019 01;18:1533033819844483

1 The Department of Urology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Prophylactic intravesical chemotherapy can decrease bladder cancer recurrence rate after nephroureterectomy for upper tract urothelial carcinoma. We aimed to compare the effect of different prophylactic intravesical chemotherapy regimens in bladder recurrence-free survival. From 2000 to 2016, a total of 270 patients treated with radical nephroureterectomy at both institutions were enrolled. Read More

Cancers (Basel) 2019 Apr 4;11(4). Epub 2019 Apr 4.

Department of Urology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.

The histone demethylase Ubiquitously Transcribed Tetratricopeptide Repeat Protein X-Linked (UTX/KDM6A) demethylates H3K27me2/3 at genes and enhancers and is often inactivated by mutations in urothelial carcinoma (UC). The consequences of its inactivation are however poorly understood. We have investigated the consequences of moderate UTX overexpression across a range of UC cell lines with or without mutations in or its interaction partners and in a normal control cell line. Read More

Urology 2019 Apr 12. Epub 2019 Apr 12.

Department of Pathology, Hospital University La Fe, Valencia, Spain. Electronic address:

Objetives: To assess if 'tumour budding' (TB) behaves as a poor prognostic factor in muscle-invasive bladder carcinoma (MIBC). TB is the presence of tumour cells isolated or in small groups of fewer than five cells located at the tumour invasion front.

Material And Methods: Retrospective study of 106 patients with MIBC who underwent radical cystectomy. Read More

Urology 2019 Apr 12. Epub 2019 Apr 12.

University of California, San Diego, San Diego, CA, USA; VA Center of Excellence for Stress and Mental Health, San Diego, CA, USA. Electronic address:

Objective: To evaluate the genetic and environmental relationship among prostatitis and other urological conditions, including benign prostatic hyperplasia (BPH) and prostate cancer (CaP), a classical twin design and biometric modeling was used. While prostatitis - characterized by pain and voiding symptoms, no clear etiology, and functional and quality of life impairments - co-occurs with other urinary conditions, the degree of shared overlapping etiological processes among them remains unclear. We examined the contribution of genetic and environmental factors to these conditions and the etiology of their associations at the level of genetic and environmental influences. Read More

J Vis Exp 2019 Mar 29(145). Epub 2019 Mar 29.

Department of Urology, Northwestern University Feinberg School of Medicine;

Murine bladder tumor models are critical for the evaluation of new therapeutic options. Bladder tumors induced with the N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) carcinogen are advantageous over cell line-based models because they closely replicate the genomic profiles of human tumors, and, unlike cell models and xenografts, they provide a good opportunity for the study of immunotherapies. However, bladder tumor generation is heterogeneous; therefore, an accurate assessment of tumor burden is needed before randomization to experimental treatment. Read More

Biomed Res Int 2019 10;2019:9681863. Epub 2019 Mar 10.

Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.

Abnormal expression of noncoding RNA molecules such as circRNA plays an important role in the development of malignant tumors. circRNAs are stable in structure and can be useful as ideal tumor markers. Advanced bladder cancer has poor treatment options and prognosis. Read More

FEBS Open Bio 2019 Apr 21;9(4):693-706. Epub 2019 Feb 21.

Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.

Histone lysine methyltransferases (HMT) comprise a subclass of epigenetic regulators; dysregulation of these enzymes affects gene expression, which may lead to tumorigenesis. Here, we performed an integrated analysis of 50 HMTs in bladder cancer and found intrinsic links between copy number alterations, mutations, gene expression levels, and clinical outcomes. Through integrative analysis, we identified six HMT genes (,,,,, and ) that may play a key role in the development and progression of bladder cancer. Read More

Dis Markers 2019 7;2019:4586405. Epub 2019 Mar 7.

Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, No. 23, Pingjiang Road, Hexi District, Tianjin 300211, China.

Purpose: To compare the expression level of apelin in muscle-invasive bladder cancer and matched paracarcinoma tissues and investigate the relationship between apelin and clinical prognosis in the patients.

Methods: To assess apelin expression by using immunohistochemical method compared with bladder tumors and matched paracarcinoma tissues. Subsequently, the correlation of apelin expression with the clinicopathological features of bladder cancer patients was analyzed. Read More

Evid Based Complement Alternat Med 2019 11;2019:6374940. Epub 2019 Mar 11.

Department of Urology, Goethe-University, Frankfurt am Main, Germany.

The natural compound curcumin exerts antitumor properties in vitro, but its clinical application is limited due to low bioavailability. Light exposure in skin and skin cancer cells has been shown to improve curcumin bioavailability; thus, the object of this investigation was to determine whether light exposure might also enhance curcumin efficacy in bladder cancer cell lines. RT112, UMUC3, and TCCSUP cells were preincubated with low curcumin concentrations (0. Read More