6 results match your criteria Bladder[Journal]

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Comparison of 2D and 3D ultrasound methods to measure serial bladder volumes during filling: Steps toward development of non-invasive ultrasound urodynamics.

Bladder (San Franc) 2018 4;5(1). Epub 2018 Jan 4.

Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA.

Objectives: Non-invasive methods to objectively characterize overactive bladder (OAB) and other forms of voiding dysfunction using real-time ultrasound are currently under development but require accurate and precise serial measurements of bladder volumes during filling. This study's objective was to determine the most accurate and precise ultrasound-based method of quantifying serial bladder volumes during urodynamics (UD).

Methods: Twelve female participants with OAB completed an extended UD procedure with the addition of serial bladder ultrasound images captured once per minute. Read More

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January 2018
16 Reads

Effect of filling rate on cystometric parameters in young and middle aged mice.

Bladder (San Franc) 2017 27;4(1). Epub 2017 Feb 27.

Laboratory of Voiding Dysfunction, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

Objectives: To investigate the effect of changing the bladder filling rate during cystometry in younger (2-3 months) and older (13-14 months) C57BL/6J male mice.

Methods: Cystometry was performed on mice under anesthesia. Voiding cycles were established in each mouse at a pump delivery rate of 17 μl/min. Read More

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http://dx.doi.org/10.14440/bladder.2017.88DOI Listing
February 2017
11 Reads

Sex differences in the MB49 syngeneic, murine model of bladder cancer.

Bladder (San Franc) 2016;3(1). Epub 2016 Feb 26.

Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Ave., MSC 504, Charleston, SC 29425, USA.

Objective: The MB49 syngeneic, murine model of bladder cancer has been widely used for more than 35 years. In humans, bladder cancer is one third as prevalent in women as in men, with a trend toward lower prevalence in parous compared to nulliparous women. Our objective was to determine if the MB49 bladder cancer model reproduces the sex differences observed in humans, and to determine its sensitivity to testosterone and the pregnancy hormone, human chorionic gonadotropin (hCG). Read More

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http://dx.doi.org/10.14440/bladder.2016.73DOI Listing
February 2016
6 Reads

Role of consolidative surgical therapy in patients with locally advanced or regionally metastatic bladder cancer.

Bladder (San Franc) 2016 ;3(2)

Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

The effect of radical cystectomy and extended pelvic lymph node dissection (RC/PLND) on the survival of patients with locally advanced and/or regionally metastatic bladder cancer is unknown. However, emerging evidence suggests that there may be survival benefit to a subset of select patients with this disease who demonstrate a response to chemotherapy. This article will review the current literature on the role of RC/PLND in the consolidative treatment of locally advanced and regionally metastatic bladder cancer. Read More

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http://dx.doi.org/10.14440/bladder.2016.89DOI Listing
January 2016
3 Reads

Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation.

Bladder (San Franc) 2015;2(2). Epub 2015 Jul 17.

Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA.

Objective: The second messenger cAMP is involved in both β3 adrenoceptor (β3-AR) mediated detrusor relaxation and the kinetics of Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Here we characterized the effect HCN channel activation and possible interaction with β3-AR in bladder.

Materials And Methods: Bladder tissues from Sprague-Dawley rats and Human organ donors were obtained for studying species-specific expression of HCN channels by real-time qPCR and Western Blot. Read More

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http://dx.doi.org/10.14440/bladder.2015.44DOI Listing
July 2015
13 Reads

The human urothelial tight junction: claudin 3 and the ZO-1α switch.

Bladder (San Franc) 2015;2(1):e9

Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York, York YO10 5DD, United Kingdom.

Objective: Tight junctions are multicomponent structures, with claudin proteins defining paracellular permeability. Claudin 3 is a candidate for the exceptional "tightness" of human urothelium, being localised to the terminal tight junction (TJ) of superficial cells. Our aim was to determine whether claudin 3 plays an instigating and/or a functional role in the urothelial TJ. Read More

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http://dx.doi.org/10.14440/bladder.2015.33DOI Listing
January 2015
21 Reads
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