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    Bilateral Testicular Loss due to Dog Bite in a Child.
    APSP J Case Rep 2017 May-Jun;8(3):20. Epub 2017 May 1.
    Department of Urology, Kobe Children's Hospital, Kobe, Japan.
    Although animal bites are common, genital trauma caused by animal bites is rare. Here we report a case of bilateral testicular loss in an infant due to a dog bite. The patient was bitten by a friend's dog while his mother was intoxicated and, therefore, did not receive immediate medical attention. Read More

    Soft Tissue Management in Facial Trauma.
    Semin Plast Surg 2017 May;31(2):73-79
    Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.
    The management of soft tissue injury after facial trauma poses unique challenges to the plastic surgeon, given the specialized nature of facial tissue and the aesthetic importance of the face. The general principles of trauma management and wound care are applied in all cases. The management of severe injuries to the face is discussed in relation to the location and the mechanism of injury. Read More

    Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Clinacanthus nutans (Burm. f.) Lindau: A comprehensive review.
    J Ethnopharmacol 2017 May 8. Epub 2017 May 8.
    Pharmacy, School of Medicine, University of Tasmania, 7001 Hobart, Tasmania, Australia.
    Ethnopharmacological Relevance: Clinacanthus nutans (Burm. f.) Lindau, a widely used medicinal plant, is extensively grown in tropical Asia and Southeast Asian countries. Read More

    Human fatalities caused by animal attacks: A six-year autopsy study.
    Med Leg J 2017 Jan 1:25817217707166. Epub 2017 Jan 1.
    1 Dept. of Forensic Medicine and Toxicology, Indira Gandhi Govt. Medical College & Hospital, Nagpur, India.
    Deaths caused by animal attacks in urban as well as rural areas are rising. With dwindling forest cover and with more interaction of animals with humans in day-to-day life, we need to understand the reasons, manner and causes of these fatal events. We studied 151 cases of fatal animal/human conflicts and in particular, the manner and mechanism of causation of injuries with respect to different types of animals. Read More

    Laboratory Animal Bite Anaphylaxis-A National Survey: Part 1: Case Series and Review of the Literature.
    J Occup Environ Med 2017 Apr 20. Epub 2017 Apr 20.
    Division of Occupational and Environmental Medicine, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.
    Objective: This study documents previously unreported cases of laboratory animal bite anaphylaxis in animal laboratory facilities in the United States.

    Methods: An online survey was e-mailed to designated institutional officials at laboratory animal facilities identified by the National Institutes of Health Office of Laboratory Animal Welfare.

    Results: One hundred ninety eight organizations responded and 15 organizations indicated that workers had experienced anaphylaxis following an animal bite. Read More

    Efficacy and user acceptability of transfluthrin-treated sisal and hessian decorations for protecting against mosquito bites in outdoor bars.
    Parasit Vectors 2017 Apr 20;10(1):197. Epub 2017 Apr 20.
    Environmental Health and Ecological Sciences Department, Ifakara Health Institute, Off Mlabani Passage, Ifakara, P.O Box 53, Morogoro, United Republic of Tanzania.
    Background: A number of mosquito vectors bite and rest outdoors, which contributes to sustained residual malaria transmission in endemic areas. Spatial repellents are thought to create a protective "bubble" within which mosquito bites are reduced and may be ideal for outdoor use. This study builds on previous studies that proved efficacy of transfluthrin-treated hessian strips against outdoor biting mosquitoes. Read More

    Thromboelastography Utilization in Delayed Recurrent Coagulopathy after Severe Eastern Diamondback Rattlesnake Envenomation.
    Am Surg 2017 Apr;83(4):332-336
    Venomous snakebites are fairly common in the United States and can present with a wide range of symptoms. A 48-year-old man presented after Eastern Diamondback rattlesnake envenomation. His hospital course was complicated by right leg compartment syndrome and delayed recurrent coagulopathy, requiring multiple doses of Crotalidae Polyvalent Immune Fab (CroFab) antivenom and transfusions. Read More

    Tick-host conflict: immunoglobulin E antibodies to tick proteins in patients with anaphylaxis to tick bite.
    Oncotarget 2017 Mar;8(13):20630-20644
    SaBio, Instituto de Investigación de Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, Ciudad Real, Spain.
    Tick-borne infectious diseases and allergies are a growing problem worldwide. Tick bite allergy has been associated with the direct effect of immunoglobulin E (IgE) response to tick salivary antigens, or secondary to the induction of allergy to red meat consumption through IgE antibodies against the carbohydrate α-Gal (Gal α 1-3Gal β 1-(3)4GlcNAc-R). However, despite the growing burden of this pathology, the proteins associated with anaphylaxis to tick bite have not been characterized. Read More

    Defining the complex phenotype of severe systemic loxoscelism using a large electronic health record cohort.
    PLoS One 2017 19;12(4):e0174941. Epub 2017 Apr 19.
    Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America.
    Objective: Systemic loxoscelism is a rare illness resulting from the bite of the recluse spider and, in its most severe form, can lead to widespread hemolysis, coagulopathy, and death. We aim to describe the clinical features and outcomes of the largest known cohort of individuals with moderate to severe loxoscelism.

    Methods: We performed a retrospective, cross sectional study from January 1, 1995, to December 31, 2015, at a tertiary-care academic medical center, to determine individuals with clinical records consistent with moderate to severe loxoscelism. Read More

    Community-based survey during rabies outbreaks in Rangjung town, Trashigang, eastern Bhutan, 2016.
    BMC Infect Dis 2017 Apr 17;17(1):281. Epub 2017 Apr 17.
    Regional Livestock Development Centre, Department of Livestock, Khangma, Trashigang, Bhutan.
    Background: Rabies is a highly fatal disease transmitted through the bite of a rabid animal. Human deaths can be prevented by prompt administering of rabies vaccine and rabies immunoglobulin following the exposure. An assessment of community knowledge, awareness and practices on rabies is important during outbreak to understand their preparedness and target educational messages and response activities by the rapid response team. Read More

    Arthropod Envenomation in North America.
    Emerg Med Clin North Am 2017 May;35(2):355-375
    Section of Emergency Medicine, University of Chicago, Chicago, IL, USA.
    Arthropods (phylum Arthopoda) account for a higher percentage of morbidity and mortality to humans than do mammalian bites, snake bites, or marine envenomation. They are ubiquitous in domestic dwellings, caves, and campsites and in wilderness settings such as deserts, forests, and lakes. Although arthropods are most intrusive during warmer months, many are active throughout the winter, particularly indoors. Read More

    North American Snake Envenomation.
    Emerg Med Clin North Am 2017 May;35(2):339-354
    Division of Medical Toxicology, Department of Emergency Medicine, UC San Diego Health, 200 West Arbor Drive # 8676, San Diego, CA 92103, USA.
    Native US snakes that produce clinically significant envenomation can be divided into 2 groups, crotalids and elapids. The crotalids include rattlesnakes, cottonmouths, and copperheads. Crotalid envenomation can result in significant local tissue damage as well as thrombocytopenia and coagulopathy. Read More

    Zika Virus: Common Questions and Answers.
    Am Fam Physician 2017 Apr;95(8):507-513
    Centers for Disease Control and Prevention, Atlanta, GA, USA.
    Since local mosquito-borne transmission of Zika virus was first reported in Brazil in early 2015, the virus has spread rapidly, with active transmission reported in at least 61 countries and territories worldwide, including the United States. Zika virus infection during pregnancy is a cause of microcephaly and other severe brain anomalies. The virus is transmitted primarily through the bite of an infected Aedes mosquito, but other routes of transmission include sexual, mother-to-fetus during pregnancy, mother-to-infant at delivery, laboratory exposure, and, possibly, transfusion of blood products. Read More

    Bacteremia caused by Bergeyella zoohelcum in an infective endocarditis patient: case report and review of literature.
    BMC Infect Dis 2017 Apr 12;17(1):271. Epub 2017 Apr 12.
    Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
    Background: Bergeyella zoohelcum is an aerobic, Gram-negative bacterium that is frequently isolated from the upper respiratory tract of dogs, cats and other mammals. Clinically, B. zoohelcum has been reported causing cellulitis, tenosynovitis, leg abscess and septicemia, which is closely connected with animal bites. Read More

    Preparation and neutralization efficacy of IgY antibodies raised against Deinagkistrodon acutus venom.
    J Venom Anim Toxins Incl Trop Dis 2017 4;23:22. Epub 2017 Apr 4.
    Animal Toxin Group, Chongqing Key Laboratory of Animal Biology, Chongqing Engineering Research Center of Bioactive Substances, Engineering Research Center of Active Substances and Biotechnology, Ministry of Education, College of Life Science, Chongqing, 401331 China.
    Background: The five-paced pit viper (Deinagkistrodon acutus), endemic to China and northern Vietnam, is responsible for most snakebites in the Chinese territory. Antivenom produced from horses is the main treatment for snakebites, but it may cause numerous clinical side effects and have other disadvantages involved in their production such as the welfare of animals. The present study was conducted aiming to develop an alternative antibody (IgY) from the egg yolk of leghorn chickens immunized with snake venom. Read More

    Successful strategies implemented towards the elimination of canine rabies in the Western Hemisphere.
    Antiviral Res 2017 Jul 4;143:1-12. Epub 2017 Apr 4.
    Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, 30329 GA, USA.
    Almost all cases of human rabies result from dog bites, making the elimination of canine rabies a global priority. During recent decades, many countries in the Western Hemisphere have carried out large-scale dog vaccination campaigns, controlled their free-ranging dog populations and enforced legislation for responsible pet ownership. This article reviews progress in eliminating canine rabies from the Western Hemisphere. Read More

    Unusual Aetiology of Pasteurella canis Biovar 2 Causing Dacryocystitis in HIV Patient: A Case Report and Review of Literature.
    J Clin Diagn Res 2017 Feb 1;11(2):DD01-DD03. Epub 2017 Feb 1.
    Senior Resident, Department of Microbiology, All India Institute of Medical Sciences , Raipur, Chhattisgarh, India .
    Pasteurella species are zoonotic bacterial pathogens implicated very infrequently in various human infections following animal bites or licks usually of dogs and cats. This case report described a rare clinical presentation of dacryocystitis caused by P.canis in a Human Immunodeficiency Virus (HIV) positive young male patient involved in caring of cattle. Read More

    Animal Bite Injuries in Children: Review of Literature and Case Series.
    Int J Clin Pediatr Dent 2017 Jan-Mar;10(1):67-72. Epub 2017 Feb 27.
    Assistant Professor,Department of Oral and Maxillofacial Surgery, Postgraduate Institute of Dental Sciences, Rohtak, Haryana, India.
    Introduction: Maxillofacial region in children is particularly vulnerable to animal bite injuries. These injuries may range from insignificant scratches to life-threatening neck and facial injuries. Children are the common victims, particularly of dog bites. Read More

    In Vitro Activity of Pexiganan and 10 Comparator Antimicrobials against 234 Isolates, Including 93 Pasteurella Species and 50 Anaerobic Bacterial Isolates Recovered from Animal Bite Wounds.
    Antimicrob Agents Chemother 2017 Jun 24;61(6). Epub 2017 May 24.
    R. M. Alden Research Laboratory, Culver City, California, USA.
    Animal bite wounds affect more than 5 million Americans annually, resulting in 300,000 emergency department visits, 10,000 hospitalizations, and an untold number of physician office visits. Various forms of topical therapy are empirically self-employed by many patients prior to seeking medical attention. Pexiganan, a 22-amino-acid synthetic cationic analogue of the peptide magainin II, acts by selectively damaging bacterial cell membranes. Read More

    Ticks and Tick Bites Presenting as "Funny Moles": A Review of Different Presentations and a Focus on Tick-borne Diseases.
    J Clin Aesthet Dermatol 2017 Mar 1;10(3):46-50. Epub 2017 Mar 1.
    Veterans Affairs Medical Center, Brooklyn, New York.
    Purpose: To describe a man with an adherent tick mimicking a melanoma, summarize the salient features of this condition, and review other cases of ticks mistaken for dermatoses. Background: Ticks are obligatory ectoparasites. Disease-causing ticks belong to two families: Ixodidae (hard ticks) and Argasidae (soft ticks). Read More

    Hot water immersion v icepacks for treating the pain of Chironex fleckeri stings: a randomised controlled trial.
    Med J Aust 2017 Apr;206(6):258-261
    Menzies School of Health, Royal Darwin Hospital, Darwin, NT.
    Objective: To investigate the effectiveness of hot water immersion for relieving the pain of major box jellyfish (Chironex fleckeri) stings.Design, interventions: Open label, randomised controlled trial comparing the effects of hot water immersion (45°C) and icepacks.Setting, participants: 42 patients with suspected C. Read More

    Repellent effect of microencapsulated essential oil in lotion formulation against mosquito bites.
    J Vector Borne Dis 2017 Jan-Mar;54(1):44-53
    Medical Entomology Unit, Institute of Medical Research, Kuala Lumpur, Malaysia.
    Background & Objectives: Many essential oils have been reported as natural sources of insect repellents; however, due to high volatility, they present low repellent effect. Formulation technique by using microencapsulation enables to control the volatility of essential oil and thereby extends the duration of repellency. In this study, the effectiveness of microencapsulated essential oils of Alpinia galanga, Citrus grandis and C. Read More

    Atypical Mycobacterial Infections of the Upper Extremity: Becoming More Atypical?
    Hand (N Y) 2017 Mar 7;12(2):188-192. Epub 2016 Jul 7.
    University of Texas Medical Branch, Galveston, USA.
    Background: Atypical mycobacterial infections are uncommon and characterized by a chronic, indolent course before diagnosis. Historically, these infections are associated with marine-related injury and/or immune dysfunction. Our institution has successfully diagnosed and treated an increasing number of these infections. Read More

    Application of diet theory reveals context-dependent foraging preferences in an herbivorous coral reef fish.
    Oecologia 2017 May 23;184(1):127-137. Epub 2017 Mar 23.
    Department of Biology and Marine Biology, Center for Marine Science, University of North Carolina Wilmington, 601 S. College Road, Wilmington, NC, 28401, USA.
    Dietary preferences of grazers can drive spatial variability in top-down control of autotroph communities, because diet composition may depend on the relative availability of autotroph species. On Caribbean coral reefs, parrotfish grazing is important in limiting macroalgae, but parrotfish dietary preferences are poorly understood. We applied diet-switching analysis to quantify the foraging preferences of the redband parrotfish (Sparisoma aurofrenatum). Read More

    Experimental demonstration of the possible role of Acanthamoeba polyphaga in the infection and disease progression in Buruli Ulcer (BU) using ICR mice.
    PLoS One 2017 22;12(3):e0172843. Epub 2017 Mar 22.
    Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
    The transmission of Buruli ulcer (BU), caused by Mycobacterium ulcerans (MU), remains puzzling although a number of hypothesis including through bites of infected aquatic insects have been proposed. We report the results of experiments using ICR mice that give credence to our hypothesis that Acanthamoeba species may play a role in BU transmission. We cocultured MU N2 and MU 1615 which expresses red fluorescent protein (RFP) and Acanthamoeba polyphaga (AP), and confirmed infected AP by Ziehl-Neelsen (ZN) staining. Read More

    [The Vulnerable Heel of Achilles: Intratendinous Abscess Following a Cat Bite].
    Z Orthop Unfall 2017 Mar 16. Epub 2017 Mar 16.
    Klinik für Unfallchirurgie und Orthopädie, BG Klinikum Unfallkrankenhaus Berlin.
    An 83-year-old patient suffered a cat bite dorsally to the Achilles tendon. In the further course, he developed an isolated intratendinous abscess of the Achilles tendon, which was surgically revised twice and subsequently healed with antibiotic treatment. In Germany, about 40,000 bite injuries of different origins occur annually. Read More

    Management and modeling approaches for controlling raccoon rabies: The road to elimination.
    PLoS Negl Trop Dis 2017 Mar 16;11(3):e0005249. Epub 2017 Mar 16.
    United States Department of Agriculture, National Wildlife Research Center, Fort Collins, Colorado, United States of America.
    Rabies is an ancient viral disease that significantly impacts human and animal health throughout the world. In the developing parts of the world, dog bites represent the highest risk of rabies infection to people, livestock, and other animals. However, in North America, where several rabies virus variants currently circulate in wildlife, human contact with the raccoon rabies variant leads to the highest per capita population administration of post-exposure prophylaxis (PEP) annually. Read More

    Molecular (ticks) and serological (humans) study of Crimean-Congo hemorrhagic fever virus in the Iberian Peninsula, 2013-2015.
    Enferm Infecc Microbiol Clin 2017 Mar 10. Epub 2017 Mar 10.
    Centro de Rickettsiosis y Enfermedades Transmitidas por Artrópodos Vectores, Departamento de Enfermedades Infecciosas, Hospital San Pedro-CIBIR, Logroño, Spain. Electronic address:
    Introduction: Crimean-Congo hemorrhagic fever (CCHF) is a viral disease, mainly transmitted through tick bite, of great importance in Public Health. In Spain, Crimean-Congo hemorrhagic fever virus (CCHFV) was detected for the first time in 2010 in Hyalomma lusitanicum ticks collected from deer in Cáceres. The aim of this study was to investigate the presence of CCHFV in ticks from Cáceres, and from other Spanish areas, and to evaluate the presence of antibodies against the virus in individuals exposed to tick bites. Read More

    Knowledge, attitudes and practices regarding rabies risk in community members and healthcare professionals: Pétionville, Haiti, 2013.
    Epidemiol Infect 2017 Jun 14;145(8):1624-1634. Epub 2017 Mar 14.
    Centers for Disease Control and Prevention,Division of High-Consequence Pathogens and Pathology,Atlanta,GA,USA.
    Haiti has the highest human rabies burden in the Western Hemisphere. There is no published literature describing the public's perceptions of rabies in Haiti, information that is critical to developing effective interventions and government policies. We conducted a knowledge, attitudes and practices survey of 550 community members and 116 health professionals in Pétionville, Haiti in 2013 to understand the perception of rabies in these populations. Read More

    A Human Case of Zoonotic Dog Tapeworm, Dipylidium caninum (Eucestoda: Dilepidiidae), in China.
    Korean J Parasitol 2017 Feb 28;55(1):61-64. Epub 2017 Feb 28.
    Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, China.
    We described a human case of zoonotic dog tapeworm, Dipylidium caninum (Eucestoda: Dilepidiidae), rarely occurring in China. The mother of a 17 month-old boy noted the appearance of small white and active worms over a month period in her son's feces, but the boy was asymptomatic except mild diarrhea. We observed 3 tapeworm proglottids resembling cucumber seeds in his stool sample. Read More

    Injecting rabies immunoglobulin (RIG) into wounds only: A significant saving of lives and costly RIG.
    Hum Vaccin Immunother 2017 Apr 22;13(4):762-765. Epub 2017 Feb 22.
    c WHO- Collaborating Centre for Research and Training on Zoonoses , Faculty of Medicine and King Chulalongkorn Memorial Hospital, Chulalongkorn University , Bangkok , Thailand.
    An increasing number of dog bite victims were being presented to public hospitals in Himachal Pradesh in 2014 amidst virtual non availability of any rabies immunoglobulin (RIG). Only a small quantity of equine rabies immunoglobulin (eRIG) was available from the government owned Central Research Institute (CRI) Kasauli. This available eRIG was used in 269 patients as an emergency response and only for local infiltration of severe bite wounds by suspected rabid dogs. Read More

    What kills everyone, gives a high for some-Recreational Snake Envenomation.
    Asian J Psychiatr 2017 Feb 21;25:106-108. Epub 2016 Oct 21.
    Centre for Addiction Medicine, Department of Psychiatry, National Institute of Mental Health Neurosciences, Bangalore, 560029, India. Electronic address:
    There are multiple reports of recreational snake envenomation describing psychotropic effects in absence of any adverse effects. This is in contradiction with known effects of snake venom. We report a case of a young male who subjected himself to repeated envenomation by a snake purported to be 'Indian Cobra' and experienced a 'high'. Read More

    Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners.
    Molecules 2017 Feb 24;22(3). Epub 2017 Feb 24.
    Faculty of Chemistry, University of Belgrade, Studentski trg 16, P.O. Box 51, 11158 Belgrade, Serbia.
    Malaria is a severe and life-threatening disease caused by Plasmodium parasites that are spread to humans through bites of infected Anopheles mosquitoes. Here, we report on the efficacy of aminoquinolines coupled to benzothiophene and thiophene rings in inhibiting Plasmodium falciparum parasite growth. Synthesized compounds were evaluated for their antimalarial activity and toxicity, in vitro and in mice. Read More

    American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
    Allergy Asthma Proc 2017 Mar;38(2):121-129
    Background: Few data exist regarding the use of venom immunotherapy (VIT) in specific high-risk chronic medical conditions and pregnancy, and in young children.

    Methods: A Web-based survey was sent to American Academy of Asthma Allergy & Immunology members to explore their VIT experience in potential high-risk medical conditions and pregnancy, and in young children. Major problems were defined as "activation of underlying disease and/or VIT not well tolerated (systemic adverse events) and/or VIT discontinued for medical reasons. Read More

    Coagulopathy and extensive local swelling following Green pit viper (Trimeresurus trigonocephalus) envenoming in Sri Lanka.
    Toxicon 2017 Apr 16;129:95-99. Epub 2017 Feb 16.
    Medical Unit, Provincial General Hospital, Ratnapura, Sri Lanka.
    Trimeresurus trigonocephalus (Sri Lankan Green pit viper) is a moderately venomous arboreal snake endemic to Sri Lanka. Even though, its bites are not uncommon, published reports of such cases are limited to three in literature. We report three cases of coagulopathy following Green pit viper bites and treatment with fresh frozen plasma. Read More

    What influences the home range size of free-roaming domestic dogs?
    Epidemiol Infect 2017 May 16;145(7):1339-1350. Epub 2017 Feb 16.
    Sydney School of Veterinary Science,The University of Sydney,Australia.
    In many regions of the world domestic dogs are free roaming and live in close relationship with humans. These free-roaming domestic dogs (FRDD) can cause public health problems such as dog bites and transmission of infectious diseases. To effectively control diseases transmitted by FRDD, knowledge on the dogs' behaviour is required. Read More

    GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci.
    Hum Mol Genet 2017 Apr;26(7):1391-1406
    Pfizer WRD, Human Genetics and Computational Biomedicine, The Portway Building, Granta Park, Cambridge CB21 6GS, UK.
    Understanding the interaction between humans and mosquitoes is a critical area of study due to the phenomenal burdens on public health from mosquito-transmitted diseases. In this study, we conducted the first genome-wide association studies (GWAS) of self-reported mosquito bite reaction size (n = 84,724), itchiness caused by bites (n = 69,057), and perceived attractiveness to mosquitoes (n = 16,576). In total, 15 independent significant (P < 5×10-8) associations were identified. Read More

    Presumptive risk factors for monkeypox in rural communities in the Democratic Republic of the Congo.
    PLoS One 2017 13;12(2):e0168664. Epub 2017 Feb 13.
    US Centers for Disease Control and Prevention, Poxvirus and Rabies Branch, Atlanta, Georgia, United States of America.
    Monkeypox virus (MPXV), a close relative of Variola virus, is a zoonotic virus with an unknown reservoir. Interaction with infected wildlife, bites from peri-domestic animals, and bushmeat hunting are hypothesized routes of infection from wildlife to humans. Using a Risk Questionnaire, performed in monkeypox-affected areas of rural Democratic Republic of the Congo, we describe the lifestyles and demographics associated with presumptive risk factors for MPXV infection. Read More

    An ethanol extract of Aster yomena (Kitam.) Honda inhibits lipopolysaccharide-induced inflammatory responses in murine RAW 264.7 macrophages.
    Biosci Trends 2017 Mar 7;11(1):85-94. Epub 2017 Feb 7.
    Department of Biochemistry, Dongeui University College of Korean Medicine.
    Aster yomena (Kitam.) Honda has been widely used as a traditional herbal medicine for centuries to treat cough, asthma, insect bites, etc. Recent reports indicate that A. Read More

    A Plasmodium vivax Plasmid DNA- and Adenovirus-Vectored Malaria Vaccine Encoding Blood-Stage Antigens AMA1 and MSP142 in a Prime/Boost Heterologous Immunization Regimen Partially Protects Aotus Monkeys against Blood-Stage Challenge.
    Clin Vaccine Immunol 2017 Apr 5;24(4). Epub 2017 Apr 5.
    Naval Medical Research Center, Silver Spring, Maryland, USA
    Malaria is caused by parasites of the genus Plasmodium, which are transmitted to humans by the bites of Anopheles mosquitoes. After the elimination of Plasmodium falciparum, it is predicted that Plasmodium vivax will remain an important cause of morbidity and mortality outside Africa, stressing the importance of developing a vaccine against P. vivax malaria. Read More

    Genetic parameters of insect bite hypersensitivity in the Old Grey Kladruber horse.
    J Anim Sci 2017 Jan;95(1):53-58
    The objective of this study was to assess the genetic parameters of insect bite hypersensitivity (IBH) in the Old Grey Kladruber horse, an original Czech warmblood horse breed. Insect bite hypersensitivity is a recurrent allergic skin disease affecting horses worldwide. Its etiology is multifactorial. Read More

    The burden of trauma at a district hospital in Malawi.
    Trop Doct 2017 Jan 1:49475517690333. Epub 2017 Jan 1.
    4 Professor of Orthopaedics and Head of Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
    Trauma disproportionately affects low- and middle-income countries, many of which do not have the surveillance systems required to design effective prevention and treatment strategies. The aim of this study was to establish such a system at a district hospital in Malawi. Data on all trauma patients presenting to Mulanje District Hospital from 14 April 2013 to 30 December 2014 were collected using a form based on the core minimum data points for injuries recommended by the World Health Organization and an injury severity assessment. Read More

    Use of polyvalent equine anti-viper serum to treat delayed coagulopathy due to suspected Sistrurus miliarius streckeri envenomation in two children.
    Clin Toxicol (Phila) 2017 Jun 6;55(5):326-331. Epub 2017 Feb 6.
    a Oklahoma Center for Poison and Drug Information , Oklahoma City , OK , USA.
    Background: Western Pygmy Rattlesnake (WPR) envenomation reportedly causes refractory and persistent coagulopathy when treated with CroFab(®) (Crotalidae Polyvalent Immune Fab). We report two cases where polyvalent equine anti-viper serum (AntivipmynTRI(®)) was used to treat recurrent coagulopathy in children.

    Case Details: The first patient was a 16-month-old male who was bitten by a confirmed WPR. Read More

    Household exposure and animal-bite surveillance following human rabies detection in Southern Ghana.
    Pan Afr Med J 2016 1;25(Suppl 1):12. Epub 2016 Oct 1.
    Ghana Health Service, Accra, Ghana.
    Introduction: Rabies remains a neglected tropical zoonotic disease with 100% case fatality rate and estimated 6,000 global mortality annually, and yet vaccine preventable. In Ghana, rabies outbreaks receive poor response. We investigated rabies in a 5-year old boy to find the source of infection, identify exposed persons for post-exposure prophylaxis and describe animal-bite surveillance in Manya-Krobo District of Ghana. Read More

    Trombiculiasis in domestic goats and humans in the state of Maranhão, Brazil.
    Rev Bras Parasitol Vet 2017 Jan-Mar;26(1):104-109. Epub 2017 Jan 26.
    Laboratório de Parasitologia, Instituto Butantan, São Paulo, SP, Brasil.
    Trombiculiasis is an infestation caused by larval mites (chiggers) of the family Trombiculidae. Here, we provide the first report on parasitism by the chigger species Eutrombicula alfreddugesi (Oudemans) and Eutrombicula batatas (Linnaeus) in goats and humans on farms in the state of Maranhão, northeastern Brazil. Severe itching and dermatitis caused by the chiggers' bites were seen. Read More

    Oncolytic Adenoviral Delivery of an EGFR-Targeting T-cell Engager Improves Antitumor Efficacy.
    Cancer Res 2017 Apr 31;77(8):2052-2063. Epub 2017 Jan 31.
    ProCure Program, IDIBELL-Institut Català d'Oncologia, L'Hospitalet de Llobregat, Spain.
    Antiviral immune responses present a major hurdle to the efficacious use of oncolytic adenoviruses as cancer treatments. Despite the existence of a highly immunosuppressive tumor environment, adenovirus-infected cells can nonetheless be efficiently cleared by infiltrating cytotoxic T lymphocytes (CTL) without compromising tumor burden. In this study, we tested the hypothesis that tumor-infiltrating T cells could be more effectively activated and redirected by oncolytic adenoviruses that were armed with bispecific T-cell-engager (BiTE) antibodies. Read More

    Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus.
    Parasit Vectors 2017 Jan 31;10(1):51. Epub 2017 Jan 31.
    Departament of Biochemistry and Immunology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, 14049-900, Brazil.
    Background: Ticks attach to and penetrate their hosts' skin and inactivate multiple components of host responses in order to acquire a blood meal. Infestation loads with the cattle tick, Rhipicephalus microplus, are heritable: some breeds carry high loads of reproductively successful ticks, whereas in others, few ticks feed and reproduce efficiently.

    Methods: In order to elucidate the mechanisms that result in the different outcomes of infestations with cattle ticks, we examined global gene expression and inflammation induced by tick bites in skins from one resistant and one susceptible breed of cattle that underwent primary infestations with larvae and nymphs of R. Read More

    Mandatory desexing of dogs: one step in the right direction to reduce the risk of dog bite? A systematic review.
    Inj Prev 2017 Jan 27. Epub 2017 Jan 27.
    School of Animal & Veterinary Sciences, University of Adelaide, Roseworthy, South Australia, Australia.
    Introduction: Preventing dog bites is an intractable problem given the complex dog bite injury environment. Desexing of dogs has the opportunity of creating a safer injury environment, given the potential links between desexing and behaviour change in dogs.

    Methods: A systematic review of the literature was conducted to examine the evidence for desexing of dogs to reduce dog bite risk within a population health paradigm. Read More

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