362,202 results match your criteria Birth defects research. Part C Embryo today : reviews[Journal]


Hypothyroxinemia Detected at 4 Weeks of Life in Preterm Infants Born at Less than 30 Weeks of Gestation.

Am J Perinatol 2020 Jun 4. Epub 2020 Jun 4.

Department of Pediatrics, University of Iowa, Iowa City, Iowa.

Objective:  Data on free thyroxine (FT4) concentrations beyond first 2 weeks of preterm infants are limited. This study was aimed to describe the association between perinatal characteristics and FT4 concentrations and the incidence of hypothyroxinemia at 4 weeks.

Study Design:  Retrospective analysis of serum thyroid function tests at 4 weeks in preterm infants <30 weeks of gestation. Read More

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http://dx.doi.org/10.1055/s-0040-1712168DOI Listing

Home Birth in the Era of COVID-19: Counseling and Preparation for Pregnant Persons Living with HIV.

Am J Perinatol 2020 Jun 4. Epub 2020 Jun 4.

Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

With the coronavirus disease 2019 (COVID-19) pandemic in the United States, a majority of states have instituted "shelter-in-place" policies effectively quarantining individuals-including pregnant persons-in their homes. Given the concern for COVID-19 acquisition in health care settings, pregnant persons with high-risk pregnancies-such as persons living with HIV (PLHIV)-are increasingly investigating the option of a home birth. Although we strongly recommend hospital birth for PLHIV, we discuss our experience and recommendations for counseling and preparation of pregnant PLHIV who may be considering home birth or at risk for unintentional home birth due to the pandemic. Read More

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http://dx.doi.org/10.1055/s-0040-1712513DOI Listing

Changes in peripheral muscle oxygenation measured with near-infrared spectroscopy in preterm neonates within the first 24 hours after birth.

Physiol Meas 2020 Jun 4. Epub 2020 Jun 4.

Department of Paediatrics Division of Neonatology, Karl Franzens Universitaet Graz, 8036 Graz, Graz, AUSTRIA.

Background: Near-infrared spectroscopy (NIRS) combined with venous occlusions enables peripheral-muscle oxygenation and perfusion monitoring. Aim of the present exploratory observational study was to evaluate peripheral-muscle oxygenation and perfusion during the first 24 hours after birth in stable preterm neonates.

Methods: Secondary outcome parameters of prospective observational studies were analysed. Read More

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http://dx.doi.org/10.1088/1361-6579/ab998bDOI Listing

Pregnancy outcomes and postpartum relapse rates in women with RRMS treated with alemtuzumab in the phase 2 and 3 clinical development program over 16 years.

Mult Scler Relat Disord 2020 May 6;43:102146. Epub 2020 May 6.

University of Cambridge, Cambridge, United Kingdom. Electronic address:

Background: Relapsing-remitting multiple sclerosis (RRMS) is frequently diagnosed in women of reproductive age. Because the use of disease-modifying therapies (DMTs) early in the disease course is increasing, it is important to evaluate the safety of DMTs in pregnant women and their developing fetuses. Alemtuzumab, approved for the treatment of relapsing forms of MS, is administered as 2 courses of 12 mg/day on 5 consecutive days at baseline and on 3 consecutive days 12 months later. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102146DOI Listing

Pathophysiologic mechanisms by which adenomyosis predisposes to postpartum haemorrhage and other obstetric complications.

Med Hypotheses 2020 May 13;143:109833. Epub 2020 May 13.

Department of Molecular and Developmental Medicine, University of Siena, Italy.

Adenomyosis is characterized by the presence of ectopic endometrium within the myometrium. This features lead to structural changes in the surrounding myometrium and endometrium resulting also in functional changes. Alterations in the myometrium are suspected to lead to defective remodeling of spiral arteries during the early stages of decidualization resulting in altered vascular resistance and defective placentation. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109833DOI Listing

Duration of labor among women with hypertensive disorders of pregnancy; A Swedish register cohort study.

Eur J Obstet Gynecol Reprod Biol 2020 May 20;251:114-118. Epub 2020 May 20.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Center for Clinical Research, Uppsala University, Falun, Sweden.

Objective: Preeclampsia is a severe obstetric complication affecting 2-8% of pregnancies. There is a common belief that women with preeclampsia experience a shorter duration of labor, where it is thought that increased inflammation that occurs with the disease facilitates labor. However, little evidence exists to support or refute this. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.024DOI Listing

Inpatient Hospital Outcomes and its Association with Insurance Type among Pediatric Neurosurgery Trauma Patients.

World Neurosurg 2020 Jun 1. Epub 2020 Jun 1.

Division of Pediatric Neurosurgery, Joe DiMaggio Children's Hospital, 1150 N 35(th) Ave., Hollywood, FL 33021, USA. Electronic address:

Objective: The aim of this study was to assess the association of insurance status and inpatient hospital outcomes among a nationally representative population of pediatric trauma neurosurgery patients.

Methods: The 2006, 2009, and 2012 Healthcare Cost and Utilization Project Kids' Inpatient Database was queried for all pediatric neurosurgery patients (birth through 17 years) with primary ICD-9-CM procedure codes for trauma or hematoma.

Results: Self-pay patients were 2. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.214DOI Listing

Seeing birth in a new light: The transformational effect of exposure to homebirth for hospital-based midwives.

Midwifery 2020 May 23;88:102755. Epub 2020 May 23.

Burnet Institute, Melbourne, VIC 3004, Australia.

Objective: The aim of the study was to explore hospital-based midwives' experiences of providing publicly-funded homebirth services in Australia.

Design: A qualitative descriptive study using a constructivist grounded theory methodology was undertaken.

Setting: Five different states or territories of Australia where publicly-funded homebirth services were operating. Read More

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http://dx.doi.org/10.1016/j.midw.2020.102755DOI Listing

Cadmium exposure during prenatal development causes progesterone disruptors in multiple generations via steroidogenic enzymes in rat ovarian granulosa cells.

Ecotoxicol Environ Saf 2020 Jun 1;201:110765. Epub 2020 Jun 1.

Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environmental Factors and Cancer, Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Xueyan Road No. 1, Minhou Coudslanty, Fuzhou, 350108, China. Electronic address:

Exposure to the heavy metal cadmium (Cd) in the environment is linked to adverse health. To fully understand the adverse effects of this important endocrine-disrupting compound (EDC) requires studies that address multigenerational effects and epigenetic mechanisms. The present study orally dosed pregnant SD rats with Cd from gestation day 1 until birth. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110765DOI Listing

Ethnic Disparities in Hospitalisation for COVID-19 in England: The Role of Socioeconomic Factors, Mental Health, and Inflammatory and Pro-inflammatory Factors in a Community-based Cohort Study.

Brain Behav Immun 2020 Jun 1. Epub 2020 Jun 1.

Department of Epidemiology and Public Health, University College London, UK.

Background: Differentials in COVID-19 hospitalisations and mortality according to ethnicity have been reported but their origin is uncertain. We examined the role of socioeconomic, mental health, and pro-inflammatory factors in a community-based sample.

Methods: We used data on 340,966 men and women (mean age 56. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.05.074DOI Listing

Prenatal Ethanol Exposure Increases Susceptibility to Depression- and Anxiety-like Behavior in Adult Female Offspring and its Underlying Mechanism.

Reprod Toxicol 2020 Jun 1. Epub 2020 Jun 1.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address:

Epidemiological investigations have found that maternal alcohol intake increases the risk of mental illness in offspring. Our study investigated changes of depression- and anxiety-like behaviors in adult offspring caused by prenatal ethanol exposure (PEE) and explored the potential mechanism. After Wistar rats were intragastrically administered ethanol at a dose of 4 g/kg·d on the 9-20th days of pregnancy, the offspring were given 21 days of chronic unpredictable mild stress (CUMS) starting from the 9th week after birth. Read More

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http://dx.doi.org/10.1016/j.reprotox.2020.05.015DOI Listing

Breast Milk Modulates Transgenerational Immune Inheritance.

Cell 2020 Jun 1. Epub 2020 Jun 1.

Maurice Müller Laboratories (Department for BioMedical Research), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3008 Bern, Switzerland. Electronic address:

ROR-γt regulatory T cells (Tregs) of the colon can prevent excessive inflammation but also delay pathogen clearance. How these cells are regulated has remained elusive. In this issue of Cell, Ramanan et al. Read More

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http://dx.doi.org/10.1016/j.cell.2020.05.030DOI Listing

Generational differences in the ranking pathways of top 100 ranked golfers.

J Sports Sci 2020 Jun 4:1-7. Epub 2020 Jun 4.

School of Kinesiology and Health Science, York University , Toronto, Canada.

The Official World Golf Ranking (OWGR) offers a rich data source that may be used by golf National Sporting Organisations (NSOs) to inform the allocation of human and financial capital. Golf has undergone many changes over the past few decades, thus before rankings data can be used for benchmarking purposes it is crucial to appraise its temporal stability. This study aimed to determine whether the ranking pathways of top 100 golfers have changed over time. Read More

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http://dx.doi.org/10.1080/02640414.2020.1769814DOI Listing

Night-sleep Duration Trajectories and Behavior in Preschoolers: Results from a Prospective Birth Cohort Study.

Behav Sleep Med 2020 Jun 4:1-13. Epub 2020 Jun 4.

Université de Paris, CRESS, INSERM , Paris, France.

Background: Short sleep duration is associated with concomitant behavioral difficulties, but the longitudinal association between sleep duration and later behavior in early childhood remains unclear. The aim was to study the association between sleep duration trajectories throughout preschool and behavior at age 5-6 years.

Participants: 1021 children of the French birth-cohort EDEN were included in this study. Read More

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http://dx.doi.org/10.1080/15402002.2020.1773467DOI Listing

Prematurity-related knowledge among mothers and fathers of very preterm infants.

J Clin Nurs 2020 Jun 4. Epub 2020 Jun 4.

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.

Objective: Empowering parents as health promoters may contribute to decrease the costs associated with prematurity. In Portugal, 8% and 1% of the births occurring in 2018 were preterm and very preterm, respectively. This study aimed to assess prematurity-related knowledge with regard to its prevalence, causes and consequences, according to sociodemographic, obstetric and offspring's characteristics, among mothers and fathers of very preterm infants. Read More

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http://dx.doi.org/10.1111/jocn.15361DOI Listing

Long-term motor and cognitive function in the children of women with inflammatory bowel disease.

J Crohns Colitis 2020 Jun 4. Epub 2020 Jun 4.

Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts and Harvard Medical School, Boston.

Introduction: Research on long-term outcomes of children exposed to inflammatory bowel disease (IBD) in utero is lacking. Maternal inflammation, IBD medications or other factors may increase the risk of developmental disabilities in the offspring.

Methods: We used the Danish National Birth Cohort, an ongoing prospective study that includes 100,419 pregnancies of 92,274 women, in conjunction with the Danish National Registries, to evaluate cognitive and motor development of the children of women with and without IBD. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjaa106DOI Listing

A modelling approach to estimate the prevalence of treatment-resistant schizophrenia in the United States.

PLoS One 2020 4;15(6):e0234121. Epub 2020 Jun 4.

Health Economics & Epidemiology Statistics, Department of Data Science, H Lundbeck A/S, Valby, Denmark.

Introduction: Schizophrenia is a condition that places a significant burden on individuals with the condition, their family, and society. A large proportion of those treated for schizophrenia do not experience treatment response and are referred to as having "treatment-resistant schizophrenia" (TRS). Expert opinion has long held that the prevalence of TRS among individuals with schizophrenia is 30%, but the basis of this estimate is unclear. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234121PLOS

Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review.

PLoS One 2020 4;15(6):e0234187. Epub 2020 Jun 4.

Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.

Background: COVID-19 has created an extraordinary global health crisis. However, with limited understanding of the effects of COVID-19 during pregnancy, clinicians and patients are forced to make uninformed decisions.

Objectives: To systematically evaluate the literature and report the maternal and neonatal outcomes associated with COVID-19. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234187PLOS

The elements of success in a comprehensive state-wide program to safely reduce the rate of preterm birth.

PLoS One 2020 4;15(6):e0234033. Epub 2020 Jun 4.

Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.

Background: In 2014, a whole-of-population and multi-faceted preterm birth prevention program was introduced in Western Australia with the single aim of safely lowering the rate of preterm birth. The program included new clinical guidelines, print and social media, and a dedicated new clinic. In the first full calendar year the rate of preterm birth fell by 7. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234033PLOS

High rate of partner violence during pregnancy in eastern Ethiopia: Findings from a facility-based study.

PLoS One 2020 4;15(6):e0233907. Epub 2020 Jun 4.

Research Centre for Generational Health and Ageing, Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.

Introduction: Intimate partner violence during pregnancy can contribute to maternal mortality and morbidity by limiting women's ability to receive maternal health services including antenatal care and skilled delivery care. In Ethiopia, evidence regarding intimate partner violence during pregnancy is limited, and no previous studies have been conducted in the Harari region. Therefore, this study aimed to investigate the prevalence and associated factors of intimate partner violence during pregnancy among women who had given birth in public hospitals in Harari regional state, eastern Ethiopia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233907PLOS

Effects of dexamethasone on foetal Doppler flow velocimetry.

J Obstet Gynaecol 2020 Jun 4:1-5. Epub 2020 Jun 4.

Obstetrics and Gynacology Department, Menouf General Hospital, Shebin El-Kom, Egypt.

Corticosteroid administration before anticipated preterm birth is a well known antenatal therapy available to improve newborn outcomes. Doppler studies of maternal and foetal vessels provide a way to understand how corticosteroid affects and improves foetal respiratory outcome. This study was registered on 8th of October, 2017 by Menoufia Faculty of Medicine Board with registration number 222-2-10-2017. Read More

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http://dx.doi.org/10.1080/01443615.2020.1742677DOI Listing

Hypogastric artery ligation in postpartum haemorrhage: a ten-year experience at a tertiary care centre.

J Obstet Gynaecol 2020 Jun 4:1-5. Epub 2020 Jun 4.

Department of Gynecology and Obstetrics, Medical Faculty of Dicle University, Diyarbakir, Turkey.

This study investigated patients who underwent bilateral hypogastric artery ligation (BHAL) due to postpartum haemorrhage (PPH). Patients who underwent BHAL because of PPH following a conservative treatment were included in this study. Placental abnormalities were referred to as placenta accreta. Read More

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http://dx.doi.org/10.1080/01443615.2020.1755623DOI Listing

[Therapeutic advances in neonatology].

Rev Med Liege 2020 May;75(5-6):415-419

Service de Néonatologie, CHU Liège, Belgique.

In this article, we will review major therapeutic advances in neonatology over the past ten years. We will discuss the antenatal administration of magnesium sulfate, the interest of hypothermia in the context of hypoxic ischaemic encephalopathy, the benefits and modalities of placental transfusion, less invasive techniques for ventilation and administration of the surfactant, possibilities to fortify breast milk and the concept of developmental care. These therapeutic advances are sometimes based on new therapeutics, sometimes on new concepts and, sometimes, on new less invasive techniques. Read More

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[Therapeutic revolution in the treatment of aortic stenosis : transcatheter aortic valve implantation (TAVI )].

Rev Med Liege 2020 May;75(5-6):300-303

Service de Cardiologie, CHU Liège, Belgique.

Eighteen years after the birth of the concept, TAVI (Transcatheter Aortic Valve Implantation) has established itself as the treatment of choice for symptomatic patients with severe aortic valve stenosis at high surgical risk. Unlike surgical prosthesis, the benefit of which has been validated in observational studies, indications for TAVI are now based on the results of large randomized trials. The TAVI revolution continues today with the miniaturization of the equipment, the development of new closure systems, the availability of a wider range of prosthesis sizes and the growing experience of operators, all contributing to the widening of indications to lower risk patients. Read More

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Untargeted Metabolomics Screen of Mid-pregnancy Maternal Serum and Autism in Offspring.

Autism Res 2020 Jun 4. Epub 2020 Jun 4.

Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, Emory University, Atlanta, Georgia, USA.

Discovering pathophysiologic networks in a blood-based approach may help to generate valuable tools for early treatment or preventive measures in autism. To date targeted or untargeted metabolomics approaches to identify metabolic features and pathways affecting fetal neurodevelopment have rarely been applied to pregnancy samples, that is, an early period potentially relevant for the development of autism spectrum disorders (ASD). We conducted a population-based study relying on autism diagnoses retrieved from California Department of Developmental Services record. Read More

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http://dx.doi.org/10.1002/aur.2311DOI Listing

The strange case of less C-sections: Hospital ownership, market concentration, and DRG-tariff regulation.

Health Econ 2020 Jun 4. Epub 2020 Jun 4.

Department of Economics and Finance, Universitá Cattolica del Sacro Cuore, Rome, Italy.

We evaluate the relationship between hospital ownership and responses to a policy providing large financial incentives for vaginal deliveries and financial disincentives for C-sections. We compare for-profit, nonprofit, and public hospitals operating in a public health care system organized according to the quasi-market model. We first theoretically show that hospital ownership matters insofar different hospitals are characterized by different ethical preferences. Read More

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http://dx.doi.org/10.1002/hec.4110DOI Listing

Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.

FASEB J 2020 Jun 4. Epub 2020 Jun 4.

Department of Cell Biology, Graduate School of Medicine, Osaka University, Suita, Japan.

Intestinal epithelial cells (IECs) are not only responsible for the digestion and absorption of dietary substrates but also function as a first line of host defense against commensal and pathogenic luminal bacteria. Disruption of the epithelial layer causes malnutrition and enteritis. Rab6 is a small GTPase localized to the Golgi, where it regulates anterograde and retrograde transport by interacting with various effector proteins. Read More

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http://dx.doi.org/10.1096/fj.202000028RDOI Listing

Methoxyacetic acid inhibits histone deacetylase and impairs axial elongation morphogenesis of mouse gastruloids in a retinoic acid signaling-dependent manner.

Birth Defects Res 2020 Jun 4. Epub 2020 Jun 4.

Developmental and Reproductive Biology Graduate Program, Institute for Biogenesis Research, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii, USA.

Background: Teratogenic potential has been linked to various industrial compounds. Methoxyacetic acid (MAA) is a primary metabolite of the widely used organic solvent and plasticizer, methoxyethanol and dimethoxyethyl phthalate, respectively. Studies using model animals have shown that MAA acts as the proximate teratogen that causes various malformations in developing embryos. Read More

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http://dx.doi.org/10.1002/bdr2.1712DOI Listing

Response of preterm infants with transient hypothyroxinemia of prematurity to the thyrotropin-releasing hormone stimulation test is characterized by a delayed decrease in thyroid stimulating hormone after the peak.

Clin Endocrinol (Oxf) 2020 Jun 4. Epub 2020 Jun 4.

Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawaramachi, Shogoin, Sakyo-ku, Kyoto-City, Kyoto, 606-8507, Japan.

Objectives: We evaluated the response to the thyrotropin-releasing hormone (TRH) stimulation test in very low birth weight (VLBW) infants to elucidate the etiology of transient hypothyroxinemia of prematurity (THOP).

Design And Methods: We performed TRH stimulation tests on 43 VLBW infants. Subjects were divided into two groups; a THOP group (N=11; basal TSH < 15 mU/L and basal FT4 ≤ 0. Read More

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http://dx.doi.org/10.1111/cen.14260DOI Listing

Gestational sleep deprivation is associated with higher offspring BMI and blood pressure.

Sleep 2020 Jun 4. Epub 2020 Jun 4.

University of Southern California, Department of Preventive Medicine, Division of Environmental Health, Los Angeles, California, USA.

Study Objectives: The objective of this study was to evaluate the association between gestational sleep deprivation and childhood adiposity and cardio metabolic profile.

Methods: Data were used from two population-based birth cohorts (Rhea study and Amsterdam Born Children and their Development study). A total of 3,608 pregnant women and their children were followed up until the age of 11 years. Read More

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http://dx.doi.org/10.1093/sleep/zsaa110DOI Listing

Incontinentia pigmenti: multisistemic genodermatosis.

Bol Med Hosp Infant Mex 2020 ;77(3):112-118

Servicio de Dermatología, Instituto Nacional de Pediatría, Ciudad de México, México.

Incontinentia pigmenti is an X-linked genodermatosis generally lethal in males; thus, it presents almost exclusively in females. It is caused by a loss-of-function mutation in the IKBKG (inhibitor of kappa polypeptide gene enhancer in B cells, kinase gamma) gene that prevents the NFкβ (nuclear factor kappa-light-chain-enhancer of activated B cells) protein from migrating to the nucleus to begin the transcription of factors that amplify the immune response and prevent apoptosis. Consequently, mutant cells become vulnerable to apoptosis when exposed to cytokines and, in turn, lead to vaso-occlusion and ischemia of tissues, such as the skin, the central nervous system and the retina. Read More

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http://dx.doi.org/10.24875/BMHIM.19000173DOI Listing
January 2020

Retinopathy of prematurity, frequency and risk factors in very low birth weight infants.

Bol Med Hosp Infant Mex 2020 ;77(3):135-141

Dirección General. Instituto Nacional de Perinatología, Ciudad de México, México.

Background: Retinopathy of prematurity (ROP) is the principal cause of blindness during childhood. The objective of this study was to analyze the frequency of ROP and risk factors associated with ROP in a cohort of very low birth weight infants.

Methods: A cases (ROP) and controls (no ROP) study of infants less than 1500 g was conducted. Read More

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http://dx.doi.org/10.24875/BMHIM.19000203DOI Listing
January 2020

Adaptation and Acceptability of a Digitally Delivered Intervention for Parents of Very Low Birth Weight Infants.

Nurs Res 2020 Jun 1. Epub 2020 Jun 1.

Department of Pediatrics, Rush University Medical Center, Chicago, IL Department of Pediatrics, Rush University Medical Center, Chicago, IL Rush University Medical Center, Chicago, IL Rush University Medical Center, Chicago, IL Rush University Medical Center, Chicago, IL.

Background: Very low birth weight infants (VLBW) are at elevated risk for behavioral problems as early as the second year of life. The purpose of this feasibility study was to evaluate the adaptation and acceptability of an existing digitally delivered behavioral parent training (BPT) program-the ezParent program, with the addition of weekly coaching calls-for parents of former VLBW infants in their second year of life.

Objectives: To assess the adaptation of ezParent for this population, we assessed parent access and use of ezParent and coaching calls; parent learning of strategies from ezParent; and changes in parenting practices or child behavior after using ezParent plus coaching calls. Read More

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http://dx.doi.org/10.1097/NNR.0000000000000445DOI Listing

Missed Nursing Care During Labor and Birth and Exclusive Breastfeeding During Hospitalization for Childbirth.

MCN Am J Matern Child Nurs 2020 May 28. Epub 2020 May 28.

Dr. Kathleen Rice Simpson is a Perinatal Clinical Nurse Specialist (Volunteer), Mercy Hospital Saint Louis, Saint Louis, MO. Dr. Simpson can be reached via email at Dr. Audrey Lyndon is a Professor and Assistant Dean for Clinical Research, NYU Rory Meyers College of Nursing, New York, NY. Dr. Joanne Spetz is a Professor, Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco, CA. Dr. Caryl L. Gay is a Research Specialist, Department of Family Health Care Nursing, University of California San Francisco School of Nursing, San Francisco, CA. Dr. Gay L. Landstrom is the System Chief Nursing Officer, Trinity Health, Livonia, MI.

Purpose: The purpose of this study was to determine associations between missed nursing care and nurse staffing during labor and birth, and exclusive breast milk feeding at hospital discharge.

Study Design And Methods: Labor and birth nurses in three states were surveyed about missed nursing care and their maternity units' adherence to the AWHONN (2010) nurse staffing guidelines for care during labor and birth, using the Perinatal Misscare Survey. Nursing responses were aggregated to the hospital level and estimated associations between missed nursing care, nurse staffing, and hospitals' exclusive breast milk feeding rates were measured using The Joint Commission's Perinatal Care Measure (PC-05). Read More

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http://dx.doi.org/10.1097/NMC.0000000000000644DOI Listing

Endometrioma surgery is associated with increased risk of subsequent assisted reproductive technology cycle cancellation; a retrospective cohort study.

J Obstet Gynaecol 2020 Jun 4:1-4. Epub 2020 Jun 4.

Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey.

The aim of this study was to assess the effect of laparoscopic removal of endometrioma on assisted reproductive technology (ART) outcome. A retrospective cohort study was conducted at a university hospital between January 2014 and December 2017. The ART group consisted of 26 women who underwent 44 ART cycles in the presence of ovarian endometrioma and the surgery group consisted of 53 women who underwent 58 ART cycles after laparoscopic removal of ovarian endometrioma/s. Read More

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http://dx.doi.org/10.1080/01443615.2020.1754366DOI Listing

Assessment of Energy and Protein Requirements in Relation to Nitrogen Kinetics, Nutrition, and Clinical Outcomes in Infants Receiving Early Enteral Nutrition Following Cardiopulmonary Bypass.

JPEN J Parenter Enteral Nutr 2020 Jun 4. Epub 2020 Jun 4.

Clinical Physiology Laboratory, Capital Institute of Pediatrics, Graduate School of Peking Union Medical College, Beijing, China.

Background: Nutrition therapies in children with congenital heart disease (CHD) after cardiopulmonary bypass (CPB) is crucial, but energy and protein requirements remain undefined. We assessed energy and protein requirements, with nitrogen kinetics and clinical outcomes, in infants with complex CHD following CPB.

Methods: Infants were randomized to control (1. Read More

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http://dx.doi.org/10.1002/jpen.1863DOI Listing

Evaluation of predictive value of biochemical markers for adverse obstetrics outcomes in pregnancies complicated by cholestasis.

Ginekol Pol 2020 ;91(5):269-276

Department of Reproduction, Chair of Obstetrics, Gynaecology, and Gynaecological Oncology, Poznan University of Medical Sciences, Poland.

Objectives: Intrahepatic cholestasis of pregnancy (ICP) is significantly more often associated with an abnormal perinatal outcome compared to a group of healthy pregnant women. The aim of the study was to analyse the correlation between the adverse perinatal outcome and the biochemical parameters in pregnancy complicated by cholestasis, and to assess their predictive value for neonatal complications.

Material And Methods: Eighty-six patients with ICP were divided into 3 groups according to their fasting serum bile acid level [group I n = 60, 10-39. Read More

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http://dx.doi.org/10.5603/GP.2020.0051DOI Listing
January 2020

Developmental Outcomes of Children Born with Neonatal Abstinence Syndrome (NAS): A Scoping Review.

Phys Occup Ther Pediatr 2020 Jun 4:1-14. Epub 2020 Jun 4.

School of Rehabilitation Therapy, Queen's University, Kingston, Ontario, Canada.

The purpose of this scoping review is to provide an overview of developmental outcomes of children diagnosed with neonatal abstinence syndrome (NAS). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework was used to guide this scoping review. A comprehensive search of CINAHL, MEDLINE, EMBASE, Web of Science, and PsycINFO was conducted using search terms related to NAS and developmental areas. Read More

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http://dx.doi.org/10.1080/01942638.2020.1766637DOI Listing

Cerebroplacental ratio (CPR) and reduced fetal movement: predicting neonatal outcomes.

J Matern Fetal Neonatal Med 2020 Jun 4:1-6. Epub 2020 Jun 4.

Faculty of Medicine, University of Exeter, Exeter, UK.

The aim of this study was to evaluate the role of cerebroplacental ratio (CPR) in term pregnancies with reduced fetal movements (RFM) and appropriate for gestational age (AGA)fetuses to predict poor neonatal outcomes. A prospective cohort study was performed on 150 singleton pregnancies with gestational age of 37-41 weeks and multiple episodes of RFM (case group) and 150 pregnancies within the same criteria only without RFM (control group). Both groups had appropriate for gestational age (AGA)fetuses. Read More

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http://dx.doi.org/10.1080/14767058.2020.1774544DOI Listing

Clinical effectiveness of position management and manual rotation of the fetal position with a U-shaped birth stool for vaginal delivery of a fetus in a persistent occiput posterior position.

J Int Med Res 2020 Jun;48(6):300060520924275

Department of Obstetrics, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China.

Objective: To examine the effects of position management, manual rotation of the fetal position, and using a U-shaped birth stool in primiparous women with a fetus in a persistent occiput posterior position.

Methods: This was a prospective pilot study of women who delivered at Gansu Provincial Maternity and Child-care Hospital between January and June 2018. The women were divided into the position management ([PM] position management, manual rotation of fetal position, use of a U-shaped birth stool at different stages, and routine nursing) and control groups (position selected by women and routine nursing). Read More

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http://dx.doi.org/10.1177/0300060520924275DOI Listing

The effect of mother's β-thalassemia minor on placental histology and neonatal outcomes.

J Matern Fetal Neonatal Med 2020 Jun 4:1-8. Epub 2020 Jun 4.

Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

β-thalassemia is a prevalent disease in Iran. The adverse effects of anemia on placental and neonatal outcomes have previously been shown. Women require additional iron during pregnancy and the anemia of women with β-thalassemia may adversely affect the neonatal outcome and increase placental abnormalities. Read More

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http://dx.doi.org/10.1080/14767058.2020.1774540DOI Listing

Multiple-dose versus single-dose gonadotropin-releasing hormone agonist after first in vitro fertilization failure associated with luteal phase deficiency: A randomized controlled trial.

Authors:
Danni Qu Yuan Li

J Int Med Res 2020 Jun;48(6):300060520926026

Medical Center for Human Reproduction, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Objective: To evaluate the efficacy and safety of multiple- versus single-dose gonadotropin-releasing hormone agonist (GnRH-a) addition to luteal phase support (LPS), in patients with a first in vitro fertilization (IVF) failure associated with luteal phase deficiency (LPD).

Methods: Eighty patients with a first IVF failure associated with LPD were randomly assigned into single-dose and multiple-dose GnRH-a groups. In the second IVF attempt, patients in the single-dose group were given standard LPS plus a single dose of GnRH-a 6 days after oocyte retrieval. Read More

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http://dx.doi.org/10.1177/0300060520926026DOI Listing

Validity and Reproducibility of a Semi-Quantitative Food-Frequency Questionnaire Designed to Measure the Nutrient Intakes of Canadian South Asian Infants at 12 Months of Age.

Can J Diet Pract Res 2020 Jun 4:1-9. Epub 2020 Jun 4.

Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON.

Validated methods to assess diet of non-European infants are sparse. We assessed the validity and reliability of a semi-quantitative food-frequency questionnaire (FFQ) for South Asian infants in Canada. We developed an 80-item FFQ to assess infant nutrient intake in the South Asian Birth Cohort study (START). Read More

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http://dx.doi.org/10.3148/cjdpr-2020-011DOI Listing

Maternal Anaemia in Pregnancy: A Significantly Greater Risk Factor for Anaemia in Australian Aboriginal Children than Low Birth Weight or Prematurity.

Matern Child Health J 2020 Jun 3. Epub 2020 Jun 3.

Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

Objectives: To identify maternal and perinatal risk factors associated with childhood anaemia.

Methods: A retrospective cohort study was conducted in three remote Katherine East Aboriginal communities in Northern Territory, Australia. Children born 2004-2014 in Community A and 2010-2014 in Community B and C, and their respective mothers were recruited into the study. Read More

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http://dx.doi.org/10.1007/s10995-020-02913-7DOI Listing

Travel Time to Title X Facilities and Teenage Birth Rates in North Carolina.

Matern Child Health J 2020 Jun 3. Epub 2020 Jun 3.

Department of Geography, University of North Carolina at Chapel Hill, CB #3220, Carolina Hall, Chapel Hill, NC, 27599, USA.

Objectives: In the United States, Title X facilities are understood to be an effective starting point for improving teenagers' reproductive health outcomes, including unintended pregnancy. We investigate geographic accessibility of Title X facilities and the relationship between geographic accessibility of Title X facilities and teenage birth rates in the state of North Carolina (NC).

Methods: Vehicular travel time from each ZCTA to its nearest Title X facility was calculated using a geographic information system and summarized as the indicator of geographic accessibility. Read More

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http://dx.doi.org/10.1007/s10995-020-02908-4DOI Listing

The ovulation trigger-OPU time interval of different ovarian protocols in ART: a retrospective study.

Arch Gynecol Obstet 2020 Jun 3. Epub 2020 Jun 3.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China.

Purpose: To explore the trends of oocyte and pregnancy outcomes over the ovulation trigger-OPU (oocyte pickup) time interval in four mainly used COH protocols.

Methods: This retrospective study was conducted between January 2013 and July 2018. The IVF/ICSI cycles of the patients with normal ovarian reserve were included. Read More

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http://dx.doi.org/10.1007/s00404-020-05568-5DOI Listing

Heterogeneous Associations Between Obesity and Reproductive-Related Factors and Specific Breast Cancer Subtypes Among Hong Kong Chinese Women.

Horm Cancer 2020 Jun 3. Epub 2020 Jun 3.

JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, SAR, China.

Previous studies reported heterogeneous associations between obesity and reproductive-related breast cancer risk factors and breast cancer intrinsic subtypes; however, few studies have been conducted in Asian populations. Here, we aimed to examine whether risks associated with established breast cancer risk factors varied by breast cancer subtypes in Chinese women. We conducted a hospital-based case-control study in Hong Kong, including a total of 2169 Chinese women. Read More

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http://dx.doi.org/10.1007/s12672-020-00386-2DOI Listing

Etiology, clinical findings and laboratory parameters in neonates with acute bacterial meningitis.

Iran J Microbiol 2020 Apr;12(2):89-97

Department of Midwifery, Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.

Background And Objectives: Neonatal meningitis is one of the most important and serious neonatal infections with a high mortality and morbidity rate. The present study aimed to investigate the causes, clinical signs, laboratory parameters and mortality rates in newborns with bacterial meningitis.

Materials And Methods: This cross-sectional study was performed on 468 neonates aged 2-28 days admitted to NICU in Ghaem Hospital Mashhad, Iran by available sampling method during 2009-2018. Read More

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Birth weight, cardiometabolic risk factors and effect modification of physical activity in children and adolescents: pooled data from 12 international studies.

Int J Obes (Lond) 2020 Jun 3. Epub 2020 Jun 3.

Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.

Objectives: Low and high birth weight is associated with higher levels of cardiometabolic risk factors and adiposity in children and adolescents, and increases the risk of cardiovascular diseases, obesity, and early mortality later in life. Moderate-to-vigorous physical activity (MVPA) is associated with lower cardiometabolic risk factors and may mitigate the detrimental consequences of high or low birth weight. Thus, we examined whether MVPA modified the associations between birth weight and cardiometabolic risk factors in children and adolescents. Read More

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http://dx.doi.org/10.1038/s41366-020-0612-9DOI Listing

Fetal macrosomia in a Hispanic/Latinx predominant cohort and altered expressions of genes related to placental lipid transport and metabolism.

Int J Obes (Lond) 2020 Jun 3. Epub 2020 Jun 3.

Department of Obstetrics and Gynecology, Howard University College of Medicine, Washington, DC, 20059, USA.

Introduction: Fetal overgrowth, termed fetal macrosomia when birth weight is >4000 g, is the major concern in the treatment of gestational diabetes mellitus (GDM). However, to date, the underlying mechanisms of fetal macrosomia have not been understood completely. Placental lipid metabolism is emerging as a critical player in fetal growth. Read More

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http://dx.doi.org/10.1038/s41366-020-0610-yDOI Listing