361,695 results match your criteria Birth Defects Research Part C-embryo Today-reviews[Journal]


Influence of maternal region of birth on neonatal outcomes of babies born small.

Acta Paediatr 2020 May 27. Epub 2020 May 27.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.

Aim: To compare neonatal outcomes of Small for Gestational Age (SGA) infants born to South Asian (SA)-born women, and Australia New Zealand (ANZ)-born women.

Methods: Retrospective cohort study at a hospital network in Australia. Maternal and neonatal data was collected for infants born SGA between 2013-2017 to SA or ANZ-born women. Read More

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http://dx.doi.org/10.1111/apa.15375DOI Listing

Budget line items for immunization in 33 African countries.

Health Policy Plan 2020 May 27. Epub 2020 May 27.

International Budget Partnership, 750 First Street NE, Suite 700, Washington, DC 20002, USA.

When seeking to ensure financial sustainability of a health programme, existence of a line item in the Ministry of Health (MOH) budget is often seen as an essential, first step. We used immunization as a reference point for cross-country comparison of budgeting methods in Sub-Saharan African countries. Study objectives were to (1) verify the number and types of budget line items for immunization services, (2) compare budget execution with budgeted amounts and (3) compare values with annual immunization expenditures reported to WHO and UNICEF. Read More

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http://dx.doi.org/10.1093/heapol/czaa040DOI Listing

Associations of Maternal Prepregnancy Body Mass Index and Gestational Weight Gain With Physical Fitness in Childhood.

Pediatr Exerc Sci 2020 May 22:1-7. Epub 2020 May 22.

Harokopio University.

Purpose: To investigate the potential associations of maternal prepregnancy body mass index (mppBMI) and gestational weight gain (GWG) with physical fitness in children.

Methods: A random sample of 5125 children and their mothers was evaluated. The mothers provided data contained in their medical booklets and pregnancy ultrasound records. Read More

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http://dx.doi.org/10.1123/pes.2020-0004DOI Listing

Evidence and possible mechanisms of rare maternal-fetal transmission of SARS-CoV-2.

J Clin Virol 2020 May 18;128:104447. Epub 2020 May 18.

IDMIT, CEA, IMVA INSERM U1184, Université Paris Saclay, Fontenay aux Roses, France. Electronic address:

While SARS-CoV-2 infection has spread rapidly worldwide, data remains scarce about the natural history of infection in pregnant women and the risk of mother-to-fetal transmission. Current data indicates that viral RNA levels in maternal blood are low and there is no evidence of placental infection with SARS-CoV-2. Published reports to date suggest that perinatal transmission of SARSCoV- 2 can occur but is rare. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104447DOI Listing

The marathon of labour-Does regular exercise training influence course of labour and mode of delivery?: Secondary analysis from a randomized controlled trial.

Eur J Obstet Gynecol Reprod Biol 2020 May 12;251:8-13. Epub 2020 May 12.

Professor, Exercise Scientist, Physical Therapist, Norwegian School of Sports Sciences, Department of Sports Medicine, Norway. Electronic address:

Objectives: Today all pregnant women are recommended to participate in moderate intensity aerobic and resistance-based physical activity/exercise ≥150 min/week. However, there are still controversies and scant knowledge on the role of regular exercise on delivery outcomes, including mode of delivery and length of active labour. In addition, nutritional counselling have often been examined together with exercise, which may independently effect the outcomes. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.014DOI Listing

Glucocorticoids as Mediators of Adverse Outcomes of Prenatal Stress.

Trends Neurosci 2020 Jun 15;43(6):394-405. Epub 2020 Apr 15.

Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. Electronic address:

A number of prenatal experiences are associated with adverse outcomes after birth, ranging from cardiovascular problems to psychiatric disease. Prenatal stress is associated with neurodevelopmental alterations that persist after birth and manifest at the behavioral level, for example, increased fearfulness, and at the physiological one, that is, brain structural and functional changes. Understanding the mechanisms that drive these lasting effects may help in preventing long-term negative outcomes of prenatal stress. Read More

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http://dx.doi.org/10.1016/j.tins.2020.03.008DOI Listing

Using Systematic Anomalous Case Analysis to Examine Sexual and Reproductive Health Outcomes in the Philippines.

Stud Fam Plann 2020 May 27. Epub 2020 May 27.

The Philippines is characterized by sustained economic growth and political stability, yet sexual and reproductive health indicators have stalled or even worsened in recent decades. We employed an innovative, mixed-methods approach-Systematic Anomalous Case Analysis-to gain insights into these worsening trends by examining sexual and reproductive decision-making among a cohort of young adults in Metro Cebu, Philippines. We first analyzed longitudinal data (1998-2009) to predict reproductive outcomes (i. Read More

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http://dx.doi.org/10.1111/sifp.12115DOI Listing

Fetal -derived macrophages persist and sequentially maturate in ovaries after birth in mice.

Eur J Immunol 2020 May 27. Epub 2020 May 27.

Institute of Biomedicine, University of Turku, Turku, FI-20520, Finland.

Macrophages, which are highly diverse in different tissues, play a complex and vital role in tissue development, homeostasis and inflammation. The origin and heterogeneity of tissue-resident monocytes and macrophages in ovaries remains unknown. Here we identify three tissue-resident monocyte populations and five macrophage populations in the adult ovaries using high-dimensional single cell mass cytometry. Read More

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http://dx.doi.org/10.1002/eji.202048531DOI Listing

Corticosterone, adrenal, and the pituitary-gonadal axis in neonatal rats: Effect of maternal separation and hypoxia.

Endocrinology 2020 May 27. Epub 2020 May 27.

Endocrine Research Laboratory, Aurora St. Luke's Medical Center, Aurora Research Institute, Milwaukee, WI.

Hypoxia, a common stressor in prematurity, leads to sexually dimorphic, short and long-term effects on the adult hypothalamic-pituitary-adrenal (HPA) and -gonadal (HPG) axes. We hypothesized that these effects are due to stress-induced increases in testosterone during early postnatal life. We evaluated this phenomenon by systematically assessing the short-term effects of normoxic or hypoxic separation on male and female pups at birth, postnatal hours (H) 2, 4, and 8, and postnatal days (PD) 2-7. Read More

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http://dx.doi.org/10.1210/endocr/bqaa085DOI Listing

Optimizing Gestational Weight Gain, Birth Weight and Perinatal Outcomes among Pregnant Women at Risk of Hypertension in Pregnancy by Regular Monitoring of Weight Gain and Blood Pressure: Study Protocol for a Pilot Randomized Controlled Trial.

JMIR Res Protoc 2020 Apr 21. Epub 2020 Apr 21.

Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, BD.

Background: Hypertensive disorders of pregnancy (HDP), including preeclampsia, complicate 10% of all pregnancies, causing maternal and fetal morbidity and mortality. In Bangladesh, 24% of all maternal deaths are directly attributed to hypertensive causes. Conventional antenatal care (ANC) practices often delay in detecting or miss HDP, which makes the women vulnerable to their adverse consequences. Read More

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http://dx.doi.org/10.2196/16676DOI Listing

Internal Version Compared With Pushing for Delivery of Cephalic Second Twins.

Obstet Gynecol 2020 Jun;135(6):1435-1443

Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Service de Gynécologie Obstétrique, Université de Paris, INSERM, U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Research Center, Obstetrical, Perinatal and Pediatric Epidemiology Team, Assistance Publique-Hôpitaux de Paris, Maternité Port-Royal, DHU risques et grossesse, Clinical Research Unit of Paris Descartes Necker Cochin, APHP, Maternité Notre Dame de Bon Secours, Groupe Hospitalier Saint-Joseph, and Assistance Publique-Hôpitaux de Paris, Hôpital Antoine Béclère, Service de Gynécologie Obstétrique, Paris, Université Paris Sud, Le Kremlin Bicêtre, CHRU de Lille, Maternité Jeanne de Flandre, and Université de Lille 2, Lille, Assistance Publique-Hôpitaux de Paris, Hôpital Trousseau, Service de Gynécologie Obstétrique, and Université Pierre et Marie Curie, Paris, Centre Hospitalier Intercommunal de Poissy, Service de Gynécologie Obstétrique, Poissy, Université de Versailles Saint-Quentin-en-Yvelines, Versailles, CHU de Strasbourg, Hôpital Hautepierre, and Université de Strasbourg, Strasbourg, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service de Gynécologie Obstétrique, Le Kremlin Bicêtre, CHU de Bordeaux, Service de Gynécologie Obstétrique, and Université de Bordeaux, Bordeaux, CHU de Toulouse, Service de Gynécologie Obstétrique, and Université Toulouse III Paul Sabatier, Toulouse, and CHU de Nantes, Service de Gynécologie Obstétrique, CIC Mère enfant, INRA, UMR 1280 Physiologie des adaptations nutritionnelles, and Université de Nantes, Nantes, France.

Objective: To assess neonatal morbidity and mortality according to whether cephalic second twins were born after internal version followed by total breech extraction or after instructions to push. We hypothesized that interval version would result in shorter intertwin delivery intervals and lower cesarean delivery rates for the second twin and therefore better neonatal outcomes.

Methods: These planned analyses of the JUMODA (JUmeaux MODe d'Accouchement) cohort, a national prospective population-based study of twin deliveries, examined births of cephalic second twins after vaginal birth of the first twin at or after 32 weeks of gestation. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003862DOI Listing

Perioperative Use of Cefazolin and Indomethacin for Physical Examination-Indicated Cerclages to Improve Gestational Latency.

Obstet Gynecol 2020 Jun;135(6):1409-1416

Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Objective: To evaluate gestational latency in individuals who did and did not receive perioperative cefazolin and indomethacin after physical examination-indicated cerclage.

Methods: This is a retrospective cohort study of all pregnant women with a singleton gestation who underwent physical examination-indicated cerclage placement and delivered at Northwestern Memorial Hospital from 2009 to 2018. Physical examination-indicated cerclage was performed in the setting of painless cervical dilation of at least 1 cm between 16 0/7 and 23 6/7 weeks of gestation. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003874DOI Listing

Factors Associated With Maternal and Neonatal Interventions at the Threshold of Viability.

Obstet Gynecol 2020 Jun;135(6):1398-1408

Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, and the Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objective: To quantify the influence of maternal sociodemographic, medical, and pregnancy characteristics on decisions to offer or receive antepartum and neonatal interventions with deliveries occurring at 22-23 weeks of gestation.

Methods: This is a case-control study of U.S. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003875DOI Listing

Antenatal Corticosteroids and Outcomes in Preterm Twins.

Obstet Gynecol 2020 Jun;135(6):1387-1397

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, and the Divisions of Perinatology and Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, and the Department of Biostatistics and Bioinformatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.

Objective: To estimate whether improvement in outcomes from antenatal corticosteroid treatment in extremely and very preterm twins is similar to that observed in singletons, and to investigate whether antenatal corticosteroid treatment has different effects according to chorionicity or birth order.

Methods: This population-based study was based on an analysis of data collected by the Neonatal Research Network of Japan from 2003 to 2015 of neonates weighing 1,500 g or less at birth, from gestational ages of 24 0/7 to 31 6/7 weeks of gestation. After propensity score matching, univariate logistic and interaction analyses were performed to compare short-term (neonatal period) and medium-term (3 years of age) outcomes of the children of mothers who received antenatal corticosteroids with those of children of mothers who did not receive antenatal corticosteroids. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003881DOI Listing

Association of Prior Cesarean Delivery With Early Term Delivery and Neonatal Morbidity.

Obstet Gynecol 2020 Jun;135(6):1367-1376

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, and the Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objective: To assess whether a history of prior cesarean delivery is associated with an increased risk of earlier delivery timing and resultant neonatal morbidity.

Methods: We performed a population-based retrospective cohort study using U.S. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003878DOI Listing

Association of Immediate Postpartum Etonogestrel Implant Insertion and Venous Thromboembolism.

Obstet Gynecol 2020 Jun;135(6):1275-1280

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.

Objective: To estimate the rate of readmissions for postpartum venous thromboembolism (VTE) during the first 30 days postdelivery between women with and without the immediate postpartum insertion of the etonogestrel contraceptive implant.

Methods: The Nationwide Readmissions Database from 2016 was used to identify women with a singleton delivery, immediate postpartum insertion of the etonogestrel contraceptive implant, and readmission for VTE within 30 days of discharge. Those with a prior history of VTE or anticoagulant therapy were excluded. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003760DOI Listing

Association of High-Potency Cannabis Use With Mental Health and Substance Use in Adolescence.

JAMA Psychiatry 2020 May 27. Epub 2020 May 27.

Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Importance: Cannabis use is consistently linked to poorer mental health outcomes, and there is evidence that use of higher-potency cannabis increases these risks. To date, no studies have described the association between cannabis potency and concurrent mental health in a general population sample or addressed confounding using longitudinal data.

Objective: To explore the association between cannabis potency and substance use and mental health outcomes, accounting for preceding mental health and frequency of cannabis use. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2020.1035DOI Listing

Application of a Mathematical Model in Determining the Spread of the Rabies Virus: Simulation Study.

JMIR Med Inform 2020 May 27;8(5):e18627. Epub 2020 May 27.

College of Mathematics, Shanxi University of Technology, Taiyuan, China.

Background: Rabies is an acute infectious disease of the central nervous system caused by the rabies virus. The mortality rate of rabies is almost 100%. For some countries with poor sanitation, the spread of rabies among dogs is very serious. Read More

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http://dx.doi.org/10.2196/18627DOI Listing

The joy and duty of a marginal teratologist.

Authors:
John J Mulvihill

Birth Defects Res 2020 May 27. Epub 2020 May 27.

Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

On the occasion of this anniversary of the Society for Birth Defects Research and Prevention, I accept the invitation to offer personal reflections on the earlier days of the Society and the importance of the discipline. My focus is on what few contributions I have offered, but more, on the value of having the teratologist's perspective on other aspects of my career in medical genetics and genetic epidemiology. Treating my professional life as a development biologist (of which teratologists are a breed), I recount the institutions I have been at, but more importantly, the people I have been influenced by, more often than not accomplished teratologists. Read More

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http://dx.doi.org/10.1002/bdr2.1713DOI Listing

Sinus pericranii, skull defects, and structural brain anomalies in TRAF7-related disorder.

Birth Defects Res 2020 May 27. Epub 2020 May 27.

UOC Neurosurgery, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Background: Several somatic mutations in TRAF7 have been reported in cancers, whereas a few germline heterozygous mutations have been recently linked to a neurodevelopmental disorder, characterized by craniofacial dysmorphisms, congenital heart defects, and digital anomalies.

Cases: We report two subjects harboring de novo heterozygous missense variants in TRAF7, namely the recurrent 1964G>A(p.Arg655Gln) and the novel missense c. Read More

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http://dx.doi.org/10.1002/bdr2.1711DOI Listing

Clinical and basic research investigations into the long-term effects of prenatal opioid exposure on brain development.

J Neurosci Res 2020 May 27. Epub 2020 May 27.

Department of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV, USA.

Coincident with the opioid epidemic in the United States has been a dramatic increase in the number of children born with neonatal abstinence syndrome (NAS), a form of withdrawal resulting from opioid exposure during pregnancy. Many research efforts on NAS have focused on short-term care, including acute symptom treatment and weaning of the infants off their drug dependency prior to authorizing their release. However, investigations into the long-term effects of prenatal opioid exposure (POE) on brain development, from the cellular to the behavioral level, have not been as frequent. Read More

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http://dx.doi.org/10.1002/jnr.24642DOI Listing

"Resumption of Sexuality and Health Education in Postpartum Period: From Jordanian Health Care Professionals' Perspectives".

J Sex Marital Ther 2020 May 27:1-10. Epub 2020 May 27.

Faculty of Nursing, Adult Health Nursing Department, The Hashemite University, Zarqa, Jordan.

to explore Jordanian health care professionals' perspectives about sexual education after giving birth. a descriptive qualitative approach was used to address the study aim. A purposive sampling method was used to recruit seven midwives, 13 nurses and two obstetricians from three Primary Health Centres. Read More

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http://dx.doi.org/10.1080/0092623X.2020.1769242DOI Listing

GLOBAL Leukemia in Children 0-14 Statistics 2018, Incidence and Mortality and Human Development Index (HDI): GLOBOCAN Sources and Methods.

Asian Pac J Cancer Prev 2020 May 1;21(5):1487-1494. Epub 2020 May 1.

Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Objective: Cancer is the second leading cause of death in children under 15 and leukemia is the most common type of cancer in this age group.  The aim of the present study is to investigate the incidence and mortality of leukemia in children aged 0-14 years and its relationship with Human Development Index (HDI in different countries of the world.  Methods: Incidence and mortality rates were obtained from GLOBOCAN and Country's income from World Bank. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1487DOI Listing

Neonatal Refeeding Syndrome and Clinical Outcome in Extremely Low Birthweight Babies.

JPEN J Parenter Enteral Nutr 2020 May 26. Epub 2020 May 26.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Background: Refeeding syndrome (RS) following preterm birth has been linked to high intravenous (IV) protein intake in the presence of low electrolyte supply. In extremely low birthweight (ELBW) babies, we aimed to determine the incidence of RS in the 5 days after birth and associations with clinical outcomes, birth characteristics, growth and nutrition.

Method: We conducted a prospective cohort study of ELBW ProVIDe Trial participants in 6 New Zealand NICUs. Read More

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http://dx.doi.org/10.1002/jpen.1934DOI Listing

Body Composition of Very Low Birth Weight Infants Fed Fortified Human Milk: A Pilot Study.

JPEN J Parenter Enteral Nutr 2020 May 26. Epub 2020 May 26.

Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.

Background: Although donor milk is increasingly fed to preterm infants, the resultant quality of growth and body composition is unknown. The aim of this pilot study was to describe the body composition of very low birth weight infants fed human milk in the neonatal intensive care unit and explore the association between the proportion of donor human milk intake and fat-free and fat mass deposition.

Methods: Body composition of thirty preterm infants fed maternal and donor human milk was measured by air displacement plethysmography. Read More

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http://dx.doi.org/10.1002/jpen.1931DOI Listing

Management of antiphospholipid syndrome.

Authors:
Anisur Rahman

Clin Rheumatol 2020 May 26. Epub 2020 May 26.

Centre for Rheumatology Research, Division of Medicine, University College London, London, UK.

Antiphospholipid syndrome (APS) is an autoimmune disease characterised by vascular thrombosis and/or pregnancy morbidity in the presence of persistently positive serum tests for antiphospholipid antibodies. Management of APS centres on preventing these clinical events and in preventing chronic damage caused by these events. In patients with thrombotic APS, long-term anticoagulation is recommended in the majority of cases. Read More

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http://dx.doi.org/10.1007/s10067-020-05183-4DOI Listing

Defining information needs in neonatal resuscitation with work domain analysis.

J Clin Monit Comput 2020 May 26. Epub 2020 May 26.

School of Clinical Medicine, The University of Queensland, St Lucia, QLD, 4072, Australia.

Objective: To gain a deeper understanding of the information requirements of clinicians conducting neonatal resuscitation in the first 10 min after birth.

Background: During the resuscitation of a newborn infant in the first minutes after birth, clinicians must monitor crucial physiological adjustments that are relatively unobservable, unpredictable, and highly variable. Clinicians' access to information regarding the physiological status of the infant is also crucial to determining which interventions are most appropriate. Read More

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http://dx.doi.org/10.1007/s10877-020-00526-7DOI Listing

Early versus late fortification of breast milk in preterm infants: a systematic review and meta-analysis.

Eur J Pediatr 2020 May 27. Epub 2020 May 27.

Department of Pediatrics, All India Institute of Medical Sciences, Gorakhpur, India.

This systematic review and meta-analysis assessed the effects of early fortification (EF) versus late fortification (LF) of breast milk (BM) on growth of preterm infants. Randomized and quasi-randomized controlled trials (RCTs) dealing with the effects of EF versus LF on growth parameters, incidence of adverse events, and duration of hospital stay in preterm infants were included. Data were pooled using the RevMan 5. Read More

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http://dx.doi.org/10.1007/s00431-020-03677-6DOI Listing

Association between amount of dopamine and infections in extremely preterm infants.

Eur J Pediatr 2020 May 26. Epub 2020 May 26.

Department of Neonatal Medicine, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka, 594-1101, Japan.

This study aimed to assess the effect of dopamine on the development of infections after birth in extremely preterm infants. We retrospectively identified 258 extremely preterm infants (born at < 28 gestational weeks) between July 2009 and December 2018 in a tertiary neonatal intensive care unit (NICU). We extracted data on potential risk factors for infection, total amount of dopamine, and infection history during NICU stay for each infant. Read More

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http://dx.doi.org/10.1007/s00431-020-03676-7DOI Listing

Pregnancy and its Outcomes in Patients After Uterine Fibroid Embolization: A Systematic Review and Meta-Analysis.

Cardiovasc Intervent Radiol 2020 May 26. Epub 2020 May 26.

Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital, Tehran University of Medical Science, Tehran, Iran.

Uterine artery embolization (UAE) has been introduced for uterine fibroid treatment for two decades. Most of the patients are in reproductive age and many want future pregnancy. In this study, we will assess fertility, pregnancy and its outcomes in patients who have undergone UAE. Read More

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http://dx.doi.org/10.1007/s00270-020-02521-6DOI Listing

Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta.

Blood 2020 May 26. Epub 2020 May 26.

University Medical Center Utrecht, Netherlands.

The defined location of a stem cell within a niche regulates its fate, behavior and molecular identity via a complex extrinsic regulation far from being fully elucidated yet. To explore the molecular characteristics and key components of the aortic microenvironment, where the first hematopoietic stem cells (HSCs) are generated during development, we performed genome-wide RNA tomography sequencing on zebrafish, chicken, mouse and human embryos. The resulting anterior-posterior and dorsal-ventral transcriptional maps provided a powerful resource for exploring genes and regulatory pathways active in the aortic microenvironment. Read More

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http://dx.doi.org/10.1182/blood.2019004446DOI Listing

Non-invasive Respiratory Support of the Premature Neonate: From Physics to Bench to Practice.

Front Pediatr 2020 8;8:214. Epub 2020 May 8.

Department of Neonatology, Lerner College of Medicine, Pediatric Institute, Cleveland Clinic, Cleveland Clinic Foundation, Cleveland, OH, United States.

Premature births continue to rise globally with a corresponding increase in various morbidities among this population. Rates of respiratory distress syndrome and the consequent development of Bronchopulmonary Dysplasia (BPD) are highest among the extremely preterm infants. The majority of extremely low birth weight premature neonates need some form of respiratory support during their early days of life. Read More

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http://dx.doi.org/10.3389/fped.2020.00214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227410PMC

Novel Strategies to Reduce Pulmonary Hypertension in Infants With Bronchopulmonary Dysplasia.

Front Pediatr 2020 8;8:201. Epub 2020 May 8.

Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States.

Bronchopulmonary dysplasia (BPD) is a developmental lung disorder of preterm infants primarily caused by the failure of host defense mechanisms to prevent tissue injury and facilitate repair. This disorder is the most common complication of premature birth, and its incidence remains unchanged over the past few decades. Additionally, BPD increases long-term cardiopulmonary and neurodevelopmental morbidities of preterm infants. Read More

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http://dx.doi.org/10.3389/fped.2020.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225259PMC

Minimally Invasive Surfactant Administration for the Treatment of Neonatal Respiratory Distress Syndrome: A Multicenter Randomized Study in China.

Front Pediatr 2020 7;8:182. Epub 2020 May 7.

Department of Pediatrics, Peking University Third Hospital, Beijing, China.

Nasal continuous positive airway pressure (nCPAP) was recommended as the initial respiratory support for spontaneous breathing in infants with very low birth weight and neonatal respiratory distress syndrome (NRDS). Less invasive surfactant administration (LISA) and minimally invasive surfactant therapy (MIST) have been reported to reduce the incidence of bronchopulmonary dysplasia (BPD). This study aimed to explore the applicability of minimally invasive surfactant administration (MISA) in China. Read More

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http://dx.doi.org/10.3389/fped.2020.00182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221055PMC

Causal Attributions in an Australian Aboriginal Family With Marfan Syndrome: A Qualitative Study.

Front Genet 2020 7;11:461. Epub 2020 May 7.

Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.

Causal attributions are important determinants of how health threats are processed and affect health-related behaviors. To date, there has been no research on causal attributions in genetic conditions in Aboriginal Australians. Forty members of a large Aboriginal Australian family with Marfan syndrome (MFS) were invited to participate in an ethically approved study exploring causal attributions, including perceived causes of phenotypic variability within the family. Read More

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http://dx.doi.org/10.3389/fgene.2020.00461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221064PMC

Cumulative Live Birth Rates After the First ART Cycle Using Flexible GnRH Antagonist Protocol vs. Standard Long GnRH Agonist Protocol: A Retrospective Cohort Study in Women of Different Ages and Various Ovarian Reserve.

Front Endocrinol (Lausanne) 2020 8;11:287. Epub 2020 May 8.

Department of Obstetrics and Gynecology, Reproductive Medical Center, The Second Affiliated Hospital, Air Force Military Medical University, Xi'an, China.

To compare the cumulative live birth rates (cLBRs) after the first assisted reproductive technology (ART) cycle using flexible gonadotropin releasing hormone (GnRH)-antagonist protocol vs. standard long GnRH agonist protocol for controlled ovarian stimulation (COS) in infertile women with different ages and ovarian reserve. Women who underwent ART treatment at our center between June 1st, 2015 and December 31st, 2018 were screened. Read More

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http://dx.doi.org/10.3389/fendo.2020.00287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225261PMC

Effectiveness and Safety of a Clonidine Adhesive Patch for Children With Tic Disorders: Study in a Real-World Practice.

Front Neurol 2020 8;11:361. Epub 2020 May 8.

Department of Pharmacy, Evidence-Based Pharmacy Center, West China Second Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.

Real-world evidence includes data from retrospective/prospective observational studies and observational registries, and provides insights beyond those addressed by randomized controlled trials. This study aimed to evaluate the effectiveness and safety of a clonidine adhesive patch (CAP) for children with tic disorder (TD) in a real-world setting (RWS). This was an open-label, non-interventional, post-marketing, observational study in a RWS. Read More

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http://dx.doi.org/10.3389/fneur.2020.00361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225288PMC

Understanding nutrient-sensing at birth.

Authors:
Anna Kriebs

Nat Rev Endocrinol 2020 May 26. Epub 2020 May 26.

Associate Editor, Nature Communications, .

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http://dx.doi.org/10.1038/s41574-020-0373-5DOI Listing

Relationship between age at giving fortified powdered cow's milk and cessation of breastfeeding on the nutritional status of a Chilean child cohort followed from birth to 3 years of age.

Eur J Clin Nutr 2020 May 26. Epub 2020 May 26.

Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Background/objectives: To examine how much of the variation in weight-for-height (WHZ) z-scores were associated with age at which breastfeeding ceased and provision of fortified cow's milk (Leche Purita Fortificada, LPF) commenced in a cohort of children studied from birth to 3 years of age.

Subjects/methods: Longitudinal data were obtained from routine medical check-ups on 8373 children from nine Chilean counties through convenience sampling. WHZ z-scores were generated at six-monthly intervals using WHO 2006 standards from birth to 3 years old (seven measurements). Read More

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http://dx.doi.org/10.1038/s41430-020-0665-9DOI Listing

Inequalities in birth weight and maternal education: a time-series study from 1996 to 2013 in Brazil.

Sci Rep 2020 May 26;10(1):8707. Epub 2020 May 26.

Research and Graduate Studies Group, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, 90035-007, Brazil.

Maternal education represents one of the most important social determinants of inequality in birth weight (BW) in developing countries. The present study sought to investigate secular trends in health inequality considering the difference in mean BW between extremes of maternal educational attainment in Brazil. Using a time-series design, data from 6,452,551 live births which occurred in all Brazilian state capitals from 1996 to 2013 were obtained from the Information System on Live Births. Read More

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http://dx.doi.org/10.1038/s41598-020-65445-8DOI Listing

Paediatric cohort studies on lower respiratory diseases and their reporting quality: systematic review of the year 2018.

Eur Respir J 2020 May 26. Epub 2020 May 26.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

The paediatric respiratory research community uses cohort studies extensively. However, the landscape of these studies and their quality of reporting has not been assessed.We performed a systematic review of publications on cohort studies reporting on paediatric lower respiratory problems published in 2018. Read More

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http://dx.doi.org/10.1183/13993003.00168-2020DOI Listing

Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells.

Proc Natl Acad Sci U S A 2020 May 26. Epub 2020 May 26.

Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, 510515 Guangzhou, China;

Fine-resolution differentiation trajectories of adult human hematopoietic stem cells (HSCs) involved in the generation of red cells is critical for understanding dynamic developmental changes that accompany human erythropoiesis. Using single-cell RNA sequencing (scRNA-seq) of primary human terminal erythroid cells (CD34CD235a) isolated directly from adult bone marrow (BM) and umbilical cord blood (UCB), we documented the transcriptome of terminally differentiated human erythroblasts at unprecedented resolution. The insights enabled us to distinguish polychromatic erythroblasts (PolyEs) at the early and late stages of development as well as the different development stages of orthochromatic erythroblasts (OrthoEs). Read More

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http://dx.doi.org/10.1073/pnas.1915085117DOI Listing

Social inequalities in low birthweight outcomes in Sri Lanka: evidence from the Demographic and Health Survey 2016.

BMJ Open 2020 May 25;10(5):e037223. Epub 2020 May 25.

Department of Social Statistics and Demography, University of Southampton, Southampton, Hampshire, UK

Objective: To investigate social inequalities underlying low birthweight (LBW) outcomes in Sri Lanka.

Design: Cross-sectional study.

Setting: This study used the Sri Lanka Demographic and Health Survey 2016, the first such survey to cover the entire country since the Civil War ended in 2001. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-037223DOI Listing

Parenthood and pregnancy in Australians receiving treatment for end-stage kidney disease: protocol of a national study of perinatal and parental outcomes through population record linkage.

BMJ Open 2020 May 25;10(5):e036329. Epub 2020 May 25.

Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.

Introduction: Achieving parenthood is challenging in individuals receiving renal replacement therapy (RRT; dialysis or kidney transplantation) for end-stage kidney disease. Decision-making regarding parenthood in RRT recipients should be underpinned by robust data, yet there is limited data on parental factors that drive adverse health outcomes. Therefore, we aim to investigate the perinatal risks and outcomes in parents receiving RRT. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-036329DOI Listing

Impact of endometrial polyps detected during the follicular phase of intrauterine insemination treatments.

Reprod Biomed Online 2020 Mar 14. Epub 2020 Mar 14.

Universitair Ziekenhuis Brussel, Centre for Reproductive Medicine, Brussels, Belgium.

Research Question: Endometrial polyps are a frequent finding during fertility treatment. Although up to 27% of small polyps (<10 mm) regress spontaneously, there is clinical benefit to removing a polyp detected before intrauterine insemination (IUI), regardless of size. However, the clinical outcome of IUI following a new suspicion of a polyp during follicle tracking is unknown. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.03.004DOI Listing

Food insecurity and psychological distress in Inuit adolescents of Nunavik.

Public Health Nutr 2020 May 27:1-11. Epub 2020 May 27.

Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, Canada.

Objective: The present study aims at measuring the association between household food insecurity and psychological distress in adolescents in Inuit communities, concurrently and overtime from childhood to adolescence.

Design: The study used measures of internalising behaviours (anxiety, withdrawn attitude, somatic complaints and depression) as indicators of psychological distress during adolescence, a concurrent measure of household food insecurity in adolescence and an assessment of longitudinal patterns of household food insecurity from childhood to adolescence. We collected descriptive information at birth, childhood and adolescence on potential confounders. Read More

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http://dx.doi.org/10.1017/S1368980020000117DOI Listing

Validation of maternal recall on exclusive breastfeeding 12 months after childbirth.

Public Health Nutr 2020 May 27:1-7. Epub 2020 May 27.

Postgraduate Program in Epidemiology, Universidade Federal de Pelotas, CEP 96020-220Pelotas, RS, Brazil.

Objective: We aimed to assess the validity of maternal recall of exclusive breastfeeding (EBF) at 3 months obtained 12 months after childbirth.

Design: A population-based birth cohort study. The gold standard is maternal report of EBF at the age of 3 months (yes or no) and age of introduction of other foods in the infant's diet. Read More

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http://dx.doi.org/10.1017/S136898002000018XDOI Listing

Socioeconomic impacts of elimination of onchocerciasis in Abu-Hamed focus, northern Sudan: lessons after elimination.

BMC Res Notes 2020 May 26;13(1):256. Epub 2020 May 26.

Public and Tropical Health Programmes, University of Medical Sciences and Technology, Khartoum, Sudan.

Objectives: Onchocerciasis is one of the most devastating neglected tropical diseases and it is mostly prevalent in Africa. The disease has important heavy social and economic burdens on the infected populations including low productivity, unemployment, social isolation, and stigma. A cross-sectional study was implemented using a well-established questionnaire to investigate the socio-economic impacts of Onchocerciasis elimination in Abu-Hamed, River Nile State, Sudan in 2015; 512 participants in ten affected communities were interviewed. Read More

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http://dx.doi.org/10.1186/s13104-020-05101-6DOI Listing

Multilocus sequence typing characterizes diversity of Ureaplasma diversum strains, and intra-species variability induces different immune response profiles.

BMC Vet Res 2020 May 26;16(1):163. Epub 2020 May 26.

Universidade Estadual de Santa Cruz, Brazil, Jorge Amado Highway, Km 16, Salobrinho, Ilheus, Bahia, 45662-900, Brazil.

Background: Ureaplasma diversum is a pathogen found in the genital tract of cattle and associated with genital disorders such as infertility, placentitis, abortion, birth of weak calves, low sperm motility, seminal vesiculitis and epididymitis. There are few studies evaluating the genetic diversity of U. diversum strains and their influence on the immune response in cattle. Read More

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http://dx.doi.org/10.1186/s12917-020-02380-wDOI Listing

Effectiveness and safety of follitropin alfa (Ovaleap®) for ovarian stimulation using a GnRH antagonist protocol in real-world clinical practice: a multicenter, prospective, open, non-interventional assisted reproductive technology study.

Reprod Biol Endocrinol 2020 May 26;18(1):54. Epub 2020 May 26.

Kinderwunsch & Hormonzentrum Frankfurt - Am Palmengarten, Private Practice, Gräfstraße 97, 60487, Frankfurt, Germany.

Background: The use of recombinant human follicle-stimulating hormone (r-hFSH) in ovarian stimulation protocols for infertility treatment in assisted reproductive technology (ART) clinical practice is well established. More recent advancements include the availability of biosimilar r-hFSH products, which expand the choices available to healthcare practitioners and patients. Better understanding of how such a product contributes to routine clinical practice is valuable to help prescribers make informed treatment choices. Read More

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http://dx.doi.org/10.1186/s12958-020-00610-2DOI Listing