340,791 results match your criteria Birth Defects Research Part A-clinical And Molecular Teratology[Journal]


Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA.

DNA methylation acts at the interface of genetic and environmental factors relevant for autism spectrum disorder (ASD). Placenta, normally discarded at birth, is a potentially rich source of DNA methylation patterns predictive of ASD in the child. Here, we performed whole methylome analyses of placentas from a prospective study MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) of high-risk pregnancies. Read More

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http://dx.doi.org/10.1093/hmg/ddz084DOI Listing

Postnatal Development of Mice with Combined Genetic Depletions of Lamin A/C, Emerin and Lamina-associated Polypeptide 1.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine.

Mutations in LMNA encoding lamin A/C and EMD encoding emerin cause cardiomyopathy and muscular dystrophy. Lmna null mice develop these disorders and have a lifespan of 7-8 weeks. Emd null mice show no overt pathology and have normal skeletal muscle but with regeneration defects. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/hmg/ddz082DOI Listing
April 2019
1 Read

Maternal Glycemic Control in Type 1 Diabetes and the Risk for Preterm Birth: A Population-Based Cohort Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Karolinska Institutet, Stockholm, Sweden, and Statens Serum Institut, Copenhagen, Denmark (B.P.).

Background: Maternal type 1 diabetes (T1D) has been linked to preterm birth and other adverse pregnancy outcomes. How these risks vary with glycated hemoglobin (or hemoglobin A1c [HbA1c]) levels is unclear.

Objective: To examine preterm birth risk according to periconceptional HbA1c levels in women with T1D. Read More

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http://dx.doi.org/10.7326/M18-1974DOI Listing

Association between child marriage and utilization of maternal health care services in India: Evidence from a nationally representative cross-sectional survey.

Midwifery 2019 Apr 18;75:66-71. Epub 2019 Apr 18.

Department of Geography, University of Gour Banga, Malda 732103, West Bengal, India.

Objective: In an effort to improve utilization of maternal health care services, age at marriage of girls has gain very little attention by the policy maker and programmer. Studies have indicated that child marriage has serious negative consequences on maternal health. Moreover, there is a paucity of research on explaining the links between child marriage and maternal health care utilization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02666138193009
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http://dx.doi.org/10.1016/j.midw.2019.04.007DOI Listing
April 2019
1 Read

The association between metformin therapy and risk of gynecological cancer in patients: Two meta-analyses.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:33-41. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Recently, metformin, first-line drug for type 2 diabetes, has been reported to treat some gynecological tumors. However, these epidemiological studies have never been formally summarized. Considering a single study may lack the power to provide reliable conclusion, we performed two meta-analyses with different indicators to assess metformin's role in reducing the risk of gynecological cancers. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.029DOI Listing

Impact of maternal depression trajectories on offspring socioemotional competences at age 11: 2004 Pelotas Birth Cohort.

J Affect Disord 2019 Mar 22;253:8-17. Epub 2019 Mar 22.

Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo, 455, 2nd floor, Sao Paulo, SP, CEP 01246-903, Brazil; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.

Background: Maternal depression is associated with impairments in child behavioural and emotional development, although the effect of exposure to maternal depression until adolescence is underexplored in most studies. This longitudinal study examined the association between maternal depressive symptoms trajectories and offspring socioemotional competences at age 11.

Methods: We included 3,437 11-year-old adolescents from the 2004 Pelotas Birth Cohort Study. Read More

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http://dx.doi.org/10.1016/j.jad.2019.03.072DOI Listing

Abdominal Pain in Children Develops With Age and Increases With Psychosocial Factors.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Div of Pediatrics, Dept of Clinical and Experimental Medicine, Linköping university SE 58185 Linköping, Sweden; Crown Princess Victoria Children´s Hospital, Region Östergötland, Linköping, Sweden.

Background & Aims: Functional gastrointestinal disorders are highly prevalent, cause significant suffering, and are costly to society. Pain is a central feature of 2 of the most common functional gastrointestinal disorders-irritable bowel syndrome and functional dyspepsia. Although these disorders have been well studied in adults, their etiology is poorly understood. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.036DOI Listing

The development of a theory-based eHealth app prototype to promote oral health during prenatal care visits.

Transl Behav Med 2019 Apr 22. Epub 2019 Apr 22.

Nudgently, LLC, Eugene, OR, USA.

Poor maternal oral health during pregnancy is associated with adverse maternal and child outcomes, including preterm birth and early childhood caries. Subsequently, professional associations have developed prenatal oral health guidelines, but significant gaps exist in implementing guidelines into clinical practice. The purpose of this study was to develop and test the usability of an innovative, theory-driven, eHealth application ("app") to facilitate prenatal providers' (nurse practitioners and midwives) implementation of oral health promotion during prenatal care visits. Read More

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http://dx.doi.org/10.1093/tbm/ibz047DOI Listing

Incidence and recurrence risk of low birth weight in Northern Tanzania: A registry based study.

PLoS One 2019 22;14(4):e0215768. Epub 2019 Apr 22.

Department of Epidemiology and Biostatistics, Institute of Public Health, Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Background: Low birth weight (LBW) is an important indicator of newborn survival. It is associated with higher risk of morbidity, mortality and long-term health consequences. Little has been done on incidence and recurrence risk of LBW in developing countries including Tanzania. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215768PLOS
April 2019
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Impact of abnormal sperm morphology on live birth rates following intrauterine insemination.

J Urol 2019 Apr 22:101097JU0000000000000288. Epub 2019 Apr 22.

Department of Urology, University of Miami , Miami , Florida.

Purpose: To evaluate live birth rates and prevalence of congenital anomalies for couples undergoing Intrauterine Insemination (IUI) with abnormal sperm morphology (<4% normal forms).

Materials & Methods: We retrospectively reviewed IUI outcomes from January 2012 to March 2015. Patients who were found to have an ultrasound confirmed clinical pregnancy were contacted to determine live birth rates and prevalence of congenital abnormalities. Read More

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http://dx.doi.org/10.1097/JU.0000000000000288DOI Listing

Influence of the Urban Exposome on Birth Weight.

Environ Health Perspect 2019 Apr;127(4):47007

4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health & Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France.

Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life.

Objective: We evaluated the association of the urban exposome with birth weight. Read More

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http://dx.doi.org/10.1289/EHP3971DOI Listing

Pregnancy and offspring outcomes after artificial insemination with donor sperm: A retrospective analysis of 1805 treatment cycles performed in Northwest China.

Medicine (Baltimore) 2019 Apr;98(16):e14975

First Clinical Medical College, Lanzhou University.

Artificial insemination with donor sperm (AID) is a widely used procedure, but its success rate in China remains uncharacterized. This study investigated the factors associated with occurrence of clinical pregnancy and live birth and evaluated the birth outcomes in the offspring after AID in Northwest China.We retrospectively reviewed the results of 1805 AID courses in 1046 couples during 2006-2015. Read More

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http://dx.doi.org/10.1097/MD.0000000000014975DOI Listing

The presentation of neuroendocrine self-peptides in the thymus: an essential event for individual life and vertebrate survival.

Ann N Y Acad Sci 2019 Apr 22. Epub 2019 Apr 22.

GIGA Institute, University of Liège, Liège-Sart Tilman, Belgium.

Confirming Burnet's early hypothesis, elimination of self-reactive T cells in the thymus was demonstrated in the late 1980s, and an important question immediately arose about the nature of the self-peptides expressed in the thymus. Many genes encoding neuroendocrine-related and tissue-restricted antigens (TRAs) are transcribed in thymic epithelial cells (TECs). They are then processed for presentation by proteins of the major histocompatibility complex (MHC) expressed by TECs and thymic dendritic cells. Read More

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http://dx.doi.org/10.1111/nyas.14089DOI Listing

Prostaglandin E receptors differentially regulate the output of proinflammatory cytokines in myometrial cells from term pregnant women.

Sheng Li Xue Bao 2019 Apr;71(2):248-260

Department of Physiology, Navy Military Medical University (Second Military Medical University), Shanghai 200433, China.

Prostaglandin (PG) E plays critical roles during pregnancy and parturition. Emerging evidence indicates that human labour is an inflammatory event. We sought to investigate the effect of PGE on the output of proinflammatory cytokines in cultured human uterine smooth muscle cells (HUSMCs) from term pregnant women and elucidate the role of subtypes of PGE receptors (EP, EP, EP and EP). Read More

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Air pollution and Autism in Denmark.

Environ Epidemiol 2018 Dec;2(4)

Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.

Background: Previous autism spectrum disorder (ASD) and air pollution studies focused on pregnancy exposures, but another vulnerable period is immediate postnatally. Here, we examined early life exposures to air pollution from the pre- to the postnatal period and ASD/ASD subtypes in the Danish population.

Methods: With Danish registers, we conducted a nationwide case-control study of 15,387 children with ASD born 1989-2013 and 68,139 population controls matched by birth year and sex identified from the birth registry. Read More

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http://dx.doi.org/10.1097/EE9.0000000000000028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474375PMC
December 2018

One year outcome of high-risk newborn infants discharged from the neonatal care unit of the National Maternal and Child Health Center in Cambodia.

Heliyon 2019 Apr 9;5(4):e01446. Epub 2019 Apr 9.

Bureau of International Health Cooperation, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo 162-8655, Japan.

Background: In the National Maternal and Child Health Center in Cambodia, about 7,500 newborn infants are born every year. Around 10% of them are admitted to the neonatal care unit. After recovery from the acute phase that presented neonatal care unit admissions, they are discharged even if they are very low birth weight infants, but there is no official follow-up system available after discharge. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183210
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http://dx.doi.org/10.1016/j.heliyon.2019.e01446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458445PMC
April 2019
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[External anthropometric measurement and pelvimetry among nulliparous women in Lubumbashi: risk factors and predictive score of mechanical dystocia].

Pan Afr Med J 2018 2;31:69. Epub 2018 Oct 2.

Département de Gynécologie-Obstétrique, Faculté de Médecine, Université de Lubumbashi, Lubumbashi, République Démocratique du Congo.

Introduction: Maternal and perinatal morbi-mortality is higher in most of sub-Saharan Africa compared to the rest of the world. All women at risk for mechanical dystocia should be screened before labor and referred to a better equipped Hospital for childbirth. This would reduce morbi-mortality. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.69.16014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457727PMC
October 2018

A cross-sectional study of traditional practices affecting maternal and newborn health in rural Nigeria.

Pan Afr Med J 2018 28;31:64. Epub 2018 Sep 28.

Department of Obstetrics and Gynaecology, Ahmadu Bello University, Zaria, Nigeria.

Introduction: Certain traditional practices which have negative effects on maternal and child health continue to be practiced in sub-Saharan African countries. A survey was carried out in a rural village in Nigeria to understand the scale and range of these practices.

Methods: This was a cross-sectional study in which trained interviewers administered pre-tested questionnaires on child-bearing women using questionnaires embedded on android devices. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.64.15880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457866PMC
September 2018

[Real macrodactylia affecting the nerves].

Pan Afr Med J 2018 27;31:61. Epub 2018 Sep 27.

Service de Radiologie, CHU Mohammed VII, 20100 Oujda, Maroc.

Real macrodactylia is a rare congenital abnormality of unknown etiology, characterized by excessive growth of the anatomical structures of one or several rays of the hand. It is usually isolated and causes a fibrofatty infiltration mainly involving the palm. It can be caused by embryonic or neurogenic abnormalities with or without nerve involvement according to whether macrodactylia has led to an increase in the volume of a major nerve, more often the median. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.61.15303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457725PMC
September 2018

Measuring Heterogeneity in Preferences over the Sex of Children.

Authors:
Johannes Norling

J Dev Econ 2018 Nov 5;135:199-221. Epub 2018 Jul 5.

Department of Economics, Mount Holyoke College.

This paper introduces a model-based approach for measuring heterogeneity in sex preferences using birth history records. The approach identifies the combinations of preferences over the sex and number of children that best explain observed childbearing. Empirical estimates indicate that a majority of parents in Africa, Asia, and the Americas consider the sex of children when making childbearing decisions. Read More

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http://dx.doi.org/10.1016/j.jdeveco.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469715PMC
November 2018

Evolution of size-dependent intraspecific competition predicts body size scaling of metabolic rate.

Funct Ecol 2019 Mar 20;33(3):479-490. Epub 2018 Dec 20.

Institute for Biodiversity and Ecosystem Dynamics University of Amsterdam Amsterdam The Netherlands.

Growth in body size is accompanied by changes in foraging capacity and metabolic costs, which lead to changes in competitive ability during ontogeny. The resulting size-dependent competitive asymmetry influences population dynamics and community structure, but it is not clear whether natural selection leads to asymmetry in intraspecific competition.We address this question by using a size-structured consumer-resource model, in which the strength and direction of competitive asymmetry between different consumer individuals depends on the scaling of maximum ingestion and maintenance metabolism with consumer body size. Read More

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http://dx.doi.org/10.1111/1365-2435.13253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472492PMC

Chronic pain, pain severity and analgesia use in Australian women of reproductive age.

Women Birth 2019 Apr 7;32(2):e272-e278. Epub 2018 Jul 7.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Electronic address:

Background: The increasing prevalence and adverse outcomes associated with opioid analgesia use in women of reproductive age have become a significant public health issue internationally, with use during pregnancy potentially affecting maternal and infant health outcomes.

Objective: This study aims to provide national estimates of chronic pain, pain severity and analgesia use in Australian women of reproductive age by pregnancy status.

Method: Data were obtained from the Australian Bureau of Statistics 2011-12 National Health Survey (n=20,426). Read More

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http://dx.doi.org/10.1016/j.wombi.2018.06.013DOI Listing

Perspectives and experiences of healthcare professionals regarding the medicalisation of pregnancy and childbirth.

Women Birth 2019 Apr 7;32(2):e173-e181. Epub 2018 Jul 7.

Department of Sociology, Faculty of Arts, University of Maribor, Koroška cesta 160, 2000 Maribor, Slovenia.

Background: Pregnancy and childbirth hold broader cultural and societal implications and entail more than simply a natural event. Today, these otherwise natural phenomena are driven by the development of surveillance medicine in a risk-averse society. This affects how both healthcare professionals and women perceive medicalisation and is influencing changes in clinical practice surrounding childbirth. Read More

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http://dx.doi.org/10.1016/j.wombi.2018.06.018DOI Listing

Fetal movement frequency and the effect of associated perinatal factors: Multicenter study.

Women Birth 2019 Apr 28;32(2):127-130. Epub 2018 Jun 28.

Perinatal Center, Shiga University of Medical Science, Japan.

Background: Decreased fetal movements are associated with adverse perinatal outcomes, including stillbirth. Delayed maternal visits to a health care provider after perceiving decreased fetal movements are frequently observed in stillbirths. Informing pregnant women of the normal range of fetal movement frequency is essential in their earlier visits in order to prevent stillbirth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18715192183021
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http://dx.doi.org/10.1016/j.wombi.2018.06.010DOI Listing

Impedance to blood flow in the umbilical arteries and infant survival in twin-to-twin transfusion syndrome.

Ultrasound Obstet Gynecol 2019 Apr 22. Epub 2019 Apr 22.

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX.

Objective: This study compares infant survival according to patterns of impedance to blood flow in the umbilical arteries (UA) among patients with twin-to-twin transfusion syndrome (TTTS).

Methods: This retrospective study included women who underwent laser surgery for TTTS between January 2012 and May 2018 at a single institution. Absolute Inter-twin difference in umbilical artery pulsatility index (DUAPI) was measured prior to laser surgery. Read More

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http://dx.doi.org/10.1002/uog.20298DOI Listing

Prediction of adverse perinatal outcomes by fetal biometry: a comparison of customized and population-based standards.

Ultrasound Obstet Gynecol 2019 Apr 22. Epub 2019 Apr 22.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS).

Objective: To compare the predictive ability of estimated fetal weight (EFW) percentiles, according to seven growth standards, to detect fetuses at risk for adverse perinatal outcomes.

Methods: This retrospective cohort study included 3,437 African-American women. Population-based (Hadlock, INTERGROWTH-21st, WHO, FMF), ethnic specific (NICHD), customized (GROW) and African American customized (PRB/NICHD) growth standards were applied to the last available scan prior to delivery. Read More

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http://dx.doi.org/10.1002/uog.20299DOI Listing

Post-traumatic stress disorder and hypertensive disorders of pregnancy among military women.

Paediatr Perinat Epidemiol 2019 Apr 21. Epub 2019 Apr 21.

College of Public Health, University of South Florida, Tampa, Florida.

Background: Women are more likely to develop post-traumatic stress disorder (PTSD) than men. Limited research exists evaluating the risk of hypertensive disorders of pregnancy (HDP) among military women with PTSD.

Methods: We conducted a retrospective cohort study using US Department of Defense (DoD) data comprised of all active-duty women giving birth to their first, liveborn singleton infant using DoD-sponsored health insurance from 1 January 2004 to 31 December 2008 (n = 34 176). Read More

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http://dx.doi.org/10.1111/ppe.12546DOI Listing

Neonatal Vitamin A Supplementation and Vitamin A Status Are Associated with Gut Microbiome Composition in Bangladeshi Infants in Early Infancy and at 2 Years of Age.

J Nutr 2019 Apr 22. Epub 2019 Apr 22.

Nutrition Department.

Background: Infancy is a crucial period for establishing the intestinal microbiome. This process may be influenced by vitamin A (VA) status because VA affects intestinal immunity and epithelial integrity, factors that can, in turn, modulate microbiome development.

Objectives: The aim of this study was to determine if neonatal VA supplementation (VAS) affected the abundance of Bifidobacterium, a beneficial commensal, or of Proteobacteria, a phylum containing enteric pathogens, in early (6-15 wk) or late (2 y) infancy. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxz034DOI Listing

Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial among Pregnant Women of Rural Bangladesh.

J Nutr 2019 Apr 22. Epub 2019 Apr 22.

Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Background: Antenatal multiple micronutrient (MM) supplementation improves birth outcomes relative to iron-folic acid (IFA) in developing countries, but limited data exist on its impact on pregnancy micronutrient status.

Objective: We assessed the efficacy of a daily MM (15 nutrients) compared with IFA supplement, each providing approximately 1 RDA of nutrients and given beginning at pregnancy ascertainment, on late pregnancy micronutrient status of women in rural Bangladesh. Secondarily, we explored other contributors to pregnancy micronutrient status. Read More

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http://dx.doi.org/10.1093/jn/nxz046DOI Listing

A way for in vitro/ex vivo egg production in mammals.

Authors:
Kanako Morohaku

J Reprod Dev 2019 Apr 20. Epub 2019 Apr 20.

Institute of Agriculture, School of Science and Technology, Division of Animal Science, Shinshu University, Nagano 399-4598, Japan.

Eggs are female germ cells that are required for producing offspring through sexual reproduction. In mammals, eggs are produced in the ovary and ovulated into the oviduct. It is well known that over 99% of eggs are degenerated without ovulation, so that many studies have attempted in vitro folliculogenesis to produce many eggs in different species for a few decades. Read More

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http://dx.doi.org/10.1262/jrd.2019-024DOI Listing

A case of functioning gonadotroph adenoma in a reproductive aged woman.

Endocr J 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, The University of Tokyo Hospital, Tokyo 1138655, Japan.

A 34-year-old woman presented our hospital with complaint of irregular menstruation and abnormal uterine bleeding lasting for a month. After her second parturition at the age of 27, her menstrual cycle had been regular, but it suddenly became irregular at the age of 30. Transvaginal ultrasound revealed the presence of ovarian mass, and the patient underwent diagnostic laparoscopic surgery. Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0066DOI Listing

Prevalence and etiology of elbow flexion contractures in brachial plexus birth injury: A scoping review.

J Pediatr Rehabil Med 2019 ;12(1):75-86

Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada.

Purpose: To synthesize the evidence on the prevalence and etiology of elbow flexion contractures secondary to brachial plexus birth injury (BPBI).

Methods: Using Arksey and O'Malley's scoping review framework, MEDLINE, EMBASE, PsycINFO, and CINAHL databases were searched, followed by a comprehensive grey literature search. Articles and abstracts of studies of all level of evidence on the prevalence, natural history, clinical presentation, etiology, and treatment of elbow flexion contractures in BPBI were included. Read More

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http://dx.doi.org/10.3233/PRM-180535DOI Listing
January 2019

Fetal growth retardation and hemorheological predictors of oxygen delivery in hypertensive vs normotensive pregnant women.

Clin Hemorheol Microcirc 2019 Apr 16. Epub 2019 Apr 16.

U1046 INSERM, UMR 9214 CNRS « Physiopathologie & Médecine Expérimentale du Cœur et des Muscles - PHYMEDEXP », Unité d'Explorations Métaboliques (CERAMM), Université de Montpellier, Département de Physiologie Clinique, Hôpital Lapeyronie CHRU Montpellier, France.

Physiological modifications of blood rheology during pregnancy and their alterations in pregnant hypertensive women have been extensively studied in the 1980's. Since vascular resistance is higher in hypertensive pregnant women whose newborns are small-for gestational-age (SGA), we investigated in a personal database if growth retardation of newborns is related to the oxygen delivery index (ratio hematocrit/blood viscosity) and to the difference between hematocrit (Hct) and the prediction of its optimal valued based on Quemada's equation. A sample of 38 hypertensive pregnant women (age 29 yr±1) was compared with 64 controls matched for age and gestational age, studied at 35±1 weeks gestation, extracted from a larger series of 162 pregnant women. Read More

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http://dx.doi.org/10.3233/CH-199002DOI Listing

Molecular characteristics and association analysis with litter size trait for porcine KLK7 gene.

Authors:
Lu Dan Liu Yonggang

Anim Biotechnol 2019 Apr 21:1-5. Epub 2019 Apr 21.

c Key Laboratory of Animal Nutrition and Feed of Yunnan Province , Yunnan Agricultural University , Kunming , China.

Kallikrein-related peptidase 7(KLK7) is a tumor-related gene. In this study, the full-length coding sequence of porcine KLK7 gene was cloned through RT-PCR. Sequence analysis revealed that the pig KLK7 gene encodes a protein of 257 amino acids which has high homology with the KLK7 protein of six species: polar bear (95%), Weddell seal(94%), dog (92%), Pacific walrus (95%), domestic cat (92%), and Amur tiger (91%). Read More

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http://dx.doi.org/10.1080/10495398.2019.1604379DOI Listing

A review of reproductive outcomes of women with two consecutive miscarriages and no living child.

J Obstet Gynaecol 2019 Apr 22:1-6. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology , University College Cork , Cork , Ireland.

The definition of recurrent miscarriage ranges from two miscarriages according to the American Society for Reproductive Medicine and the European Society of Human Reproduction and Embryology, to three consecutive pregnancy losses as defined by the Royal College of Obstetricians and Gynaecologists. Recent guidelines emphasise the need for further research on the effect of various recurrent miscarriage definitions on diagnosis, treatment and prognosis. Our study examines the management and pregnancy outcomes of nulliparous women attending Cork University Maternity Hospital's Pregnancy Loss Clinic, between 2009 and 2014, with their second consecutive first-trimester miscarriage. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
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http://dx.doi.org/10.1080/01443615.2019.1576600DOI Listing
April 2019
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Understanding Barriers to Uptake of 17 alpha-hydroxyprogesterone caproate (17-OHP) in Women with History of preterm Birth.

J Matern Fetal Neonatal Med 2019 Apr 21:1-11. Epub 2019 Apr 21.

e Denver Health and Hospital Authority , Women's Care Clinic , Denver , Colorado , USA.

Background: Premature birth is responsible for approximately 38% of infant deaths as well as a host of complications, including abnormal lung development, infection, and long-term disabilities. For women with a history of spontaneous preterm birth in a singleton pregnancy, use of 17 alpha-hydroxyprogesterone caproate (17-OHP) can reduce the risk of a recurrent preterm birth by up to 42%. However, less than half of eligible women currently receive 17-OHP. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610736DOI Listing

Low grade intraventricular hemorrhage of preterm infants: neurodevelopmental and motor outcome.

J Matern Fetal Neonatal Med 2019 Apr 21:1-11. Epub 2019 Apr 21.

a National and Kapodistrian University of Athens , Medical School , Athens , Greece.

Intraventricular hemorrhage (IVH) is a main complication of prematurity, inversely associated with gestational age and birth weight. Low-grade IVH (I and II), diagnosed by cranial ultrasound, had long been considered rather not to affect neurodevelopmental and motor outcome, a view challenged by several literature reports. However, diversity in studies design, periods of subjects' collection, cohort characteristics, demographic data, maternal or neonatal comorbidities, neuroimaging methods, evaluation tools, short-or-long-term follow-up by the same or different examiners, as well as other parameters and confounders make comparisons among reports very difficult, not allowing solid conclusions. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610741DOI Listing

Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term.

J Matern Fetal Neonatal Med 2019 Apr 21:1-11. Epub 2019 Apr 21.

a Perinatology Research Branch , Division of Obstetrics and Maternal Fetal Medicine , Division of Intramural Research , Eunice Kennedy Shriver National Institute of Child Health and Human Development , National Institutes of Health , U. S. Department of Health and Human Services , Bethesda , Maryland, and Detroit, Michigan, USA.

Objective: Pyroptosis is an inflammatory form of programed cell death that is mediated by the activation of the inflammasome and depends on the pore-forming function of gasdermin D. Therefore, the detection of gasdermin D represents in vivo evidence of pyroptosis. We recently showed that there is intra-amniotic inflammasome activation in spontaneous labor at term; however, evidence of pyroptosis is lacking. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610740DOI Listing

Maternal periconceptional body mass index and risk for neural tube defects: results from a large cohort study in China.

J Matern Fetal Neonatal Med 2019 Apr 22:1-7. Epub 2019 Apr 22.

a Institute of Reproductive and Child Health , Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China , Beijing , P. R. China.

Background: Case-control studies have consistently suggested an association between pre- or periconceptional maternal obesity and an increased risk for neural tube defects (NTDs). Few studies have examined the association between body mass index (BMI) and NTDs using measured weight and height. We examined this association in a large cohort study in China. Read More

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http://dx.doi.org/10.1080/14767058.2019.1606192DOI Listing

Use of gestational surrogates for women with Eisenmenger syndrome: a cost-effectiveness analysis.

J Matern Fetal Neonatal Med 2019 Apr 21:1-181. Epub 2019 Apr 21.

a Department of Obstetrics & Gynecology , Oregon Health & Sciences University , Portland , Oregon , USA.

Objective: Eisenmenger syndrome is regarded as a contraindication to pregnancy, with therapeutic abortion recommended in the event of unintended pregnancy. However, women with Eisenmenger syndrome continue to desire and attempt pregnancy despite grave risks to their own health. This study compares the costs and outcomes of pregnancy in women with Eisenmenger syndrome to the use of gestational surrogates in their pregnancies. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1610734DOI Listing

[Dose-response relationship between maternal hemoglobin concentration and preterm birth, in pregnant women].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):471-474

Department of Epidemiology and Health Statistic, School of Public Health, Guangxi Medical University, Nanning 530021, China.

To investigate the dose-response relationship between hemoglobin concentration and preterm birth, during pregnancy. With Zhuang ethnicity, a total of 12 780 pregnant women and their infants that admitted to Wuming、Pingguo、Jingxi、Debao、Longan and Tiandong hospitals, were recruited, in Guangxi Zhuang Autonomous Region, from January 2015 to December 2017. Non-conditional logistic regression method was used to analyze the effect of anemia on preterm birth during pregnancy. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.019DOI Listing
April 2019
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[Genetic analysis and prenatal diagnosis of Duchenne or Becker muscular dystrophy].

Zhonghua Fu Chan Ke Za Zhi 2019 Apr;54(4):226-231

Genetic Testing Center, Qingdao Women and Children's Hospital, Qingdao 266034, China.

To explore the mutation characteristics of DMD gene in patients with Duchenne or Becker muscular dystrophy and female carriers, to provide effective prenatal diagnosis. Samples were collected from 94 male patients clinically diagnosed with Duchenne or Becker muscular dystrophy and 121 corresponding female relatives from Qingdao Women and Childrens Hospital from June 2011 to October 2018. Multiplex ligation-dependent probe amplification (MLPA) was used to detect their DMD gene, and 23 high risk pregnants were performed prenatal diagnosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.04.003DOI Listing

[Study of genetic etiology in fetuses with severely short limbs in the first and second trimester using whole exome sequencing].

Zhonghua Fu Chan Ke Za Zhi 2019 Apr;54(4):221-225

Department of Obstetrics and Gynecology, Chinese PLA General Hospital, Beijing 100853, China.

To investigate pathogenic genes related to the phenotype of fetus with severely short limbs in the first and second trimester by whole exome sequencing (WES). Thirteen fetuses with severely short limbs detected by ultrasonography in the first and second trimester admitted in Chinese PLA General Hospital from September 2016 to June 2018 were collected. All cases were performed induced abortion, 6 of which were carried out karyotype analysis of amniotic fluid at the same time. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.04.002DOI Listing

Clomiphene citrate and neural tube defects: a meta-analysis of controlled observational studies.

BJOG 2019 Apr 21. Epub 2019 Apr 21.

Service Hospitalo-Universitaire de Pharmaco-Toxicologie, Hospices Civils de Lyon, France.

Background: At the end of the 80's several studies have suggested a potential increased risk of neural tube defects (NTDs) with ovulation induction/fertility drugs, especially with clomiphene citrate (CC). A previous meta-analysis of observational studies evaluating the risk of NTDs associated with the use of CC performed in 1995 found a risk ratio of 1.08 (95% confidence intervals (CI) 0. Read More

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http://dx.doi.org/10.1111/1471-0528.15800DOI Listing

Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study.

BJOG 2019 Apr 21. Epub 2019 Apr 21.

Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Objective: To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.

Design: Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS).

Settings: Rural New Hampshire, US. Read More

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http://dx.doi.org/10.1111/1471-0528.15799DOI Listing

Influenza and pertussis vaccination of women during pregnancy in Victoria, 2015-2017.

Med J Aust 2019 Apr 21. Epub 2019 Apr 21.

Monash University, Melbourne, VIC.

Objectives: To assess variations by time of year and hospital in the uptake of influenza and pertussis vaccinations by pregnant women in Victoria; to identify factors associated with vaccination uptake.

Design, Setting: Retrospective analysis of data in the Victorian Perinatal Data Collection (VPDC), a population surveillance system for obstetric conditions, procedures, and pregnancy and birth outcomes.

Participants: Women whose pregnancies ended in a live or stillbirth during July 2015 - June 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50125
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http://dx.doi.org/10.5694/mja2.50125DOI Listing
April 2019
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The Swedish Neonatal Quality Register (SNQ) - contents, completeness and validity.

Acta Paediatr 2019 Apr 21. Epub 2019 Apr 21.

Swedish Neonatal Quality Register (SNQ).

Aim: To describe the Swedish Neonatal Quality Register (SNQ) and to determine its completeness and agreement with other registers.

Methods: SNQ collects data for infants admitted to neonatal units during the first four postnatal weeks. Completeness and registers' agreement were determined crosslinking SNQ data with Swedish population registers (the Inpatient, Medical Birth and Cause of Death Registers) for a study period of five years. Read More

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http://dx.doi.org/10.1111/apa.14823DOI Listing

Micronutrient status and leukocyte telomere length in school-age Colombian children.

Eur J Nutr 2019 Apr 20. Epub 2019 Apr 20.

Department of Epidemiology, University of Michigan School of Public Health, Room 5507 SPH II, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.

Purpose: Leukocyte telomere length (LTL) is a biomarker of inflammation and oxidative stress that predicts chronic disease risk. Nutritional factors are related to LTL in adulthood, but these associations are not well characterized in children. We examined whether micronutrient status biomarkers were associated with LTL in school-age children. Read More

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http://dx.doi.org/10.1007/s00394-019-01966-xDOI Listing

Children Born to Mothers with Rash During Zika Virus Epidemic in Brazil: First 18 Months of Life.

J Trop Pediatr 2019 Apr 21. Epub 2019 Apr 21.

Faculdade de Medicina, Universidade Federal Fluminense, RJ 24.033-900, Brazil.

Objective: To better understand the clinical spectrum and course of congenital Zika syndrome (CZS) during the first 18 months of life of children whose mothers had rash during pregnancy.

Methods: This longitudinal observational study evaluated the clinical progress from birth until 18 months of life of children of mothers who developed rash during or up to 3 months before gestation. Maternal rash occurred from November 2015 to May 2017. Read More

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https://academic.oup.com/tropej/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/tropej/fmz019DOI Listing
April 2019
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