334,314 results match your criteria Birth Defects Research Part A: Clinical and Molecular Teratology[Journal]


Apgar Scoring System in Brazil's Live Births Records: Differences between Home and Hospital Births.

Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology and Oncology, Universidade de São Paulo, São Paulo, SP, Brazil.

Objective:  To promote informed choice for women and to compare home and hospital births in relation to the Apgar score.

Methods:  Mother's profile and Apgar score of naturally born infants (without forceps assistance) in Brazil between 2011 and 2015, in both settings-hospital or home-were collected from live birth records provided by the Informatics Department of the Unified Health System (DATASUS, in the Portuguese acronym). For the analysis, were included only data from low-risk deliveries, including gestational time between 37 and 41 weeks, singleton pregnancy, at least four visits of prenatal care, infants weighing between 2,500 g, and 4,000 g, mother age between 20-40 years old, and absence of congenital anomalies. Read More

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December 2018

Detecting moderate or complex congenital heart defects in adults from an electronic health records system.

J Am Med Inform Assoc 2018 Dec;25(12):1634-1642

Emory University School of Medicine, Atlanta, GA, USA.

Background: The prevalence of moderate or complex (moderate-complex) congenital heart defects (CHDs) among adults is increasing due to improved survival, but many patients experience lapses in specialty care or their CHDs are undocumented in the medical system. There is, to date, no efficient approach to identify this population.

Objective: To develop and assess the performance of a risk score to identify adults aged 20-60 years with undocumented specific moderate-complex CHDs from electronic health records (EHR). Read More

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December 2018
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Cumulative live birth rate prognosis based on the number of aspirated oocytes in previous ART cycles.

Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Kettegård Allé 26, Hvidovre, Denmark.

Study Question: Is the number of aspirated oocytes in the first ART cycle associated with the cumulative live birthrates (CLBR) in subsequent cycles?

Summary Answer: The number of aspirated oocytes in the first cycle was associated with CLBR in subsequent cycles. Previous treatment response predicts outcome in future cycles.

What Is Known Already: Previous reports have shown a positive association between the number of retrieved oocytes and live birthrate per fresh treatment cycle. Read More

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December 2018

Maternal Stress During Pregnancy Is Associated with Decreased Cortisol and Cortisone Levels in Neonatal Hair.

Horm Res Paediatr 2018 Dec 12:1-9. Epub 2018 Dec 12.

Department of Pediatric Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.

Background: Hair glucocorticoids (GCs) offer a retrospective view on chronic GC exposure. We assessed whether maternal pre- and postnatal stress was associated with neonatal and maternal hair GCs postpartum (pp).

Methods: On the first day pp 172 mother-infant pairs donated hair, of whom 67 had consulted a centre of expertise for psychiatric disorders during pregnancy. Read More

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December 2018

Evaluating the impact of meloxicam oral suspension administered at parturition on subsequent production, health, and culling in dairy cows: A randomized clinical field trial.

PLoS One 2018 12;13(12):e0209236. Epub 2018 Dec 12.

Solvet Animal Health, Calgary, Alberta, Canada.

Parturition is a painful event experienced by cows at the onset of lactation. This pain could lead to a reduced feed intake, altered metabolic and immunological status, and a host of other diseases that could seriously limit her productive herd lifespan. The objective of the current study was to assess the effect of administration of a single dose of oral meloxicam, a non-steroidal anti-inflammatory drug (NSAID), on the production and health status of cows during their lactation. Read More

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December 2018

Impact of surfactant administration through a thin catheter in the delivery room: A quality control chart analysis coupled with a propensity score matched cohort study in preterm infants.

PLoS One 2018 12;13(12):e0208252. Epub 2018 Dec 12.

Department of Pediatrics, University of Rennes 1,Rennes, France.

Introduction: Most infants born before 30 weeks gestational age (GA) develop respiratory distress syndrome soon after birth. Methods of surfactant administration that avoid ventilation have been recently introduced. The aim of this study was to evaluate the impact of implementing a new procedure of less invasive surfactant administration (LISA) and determine whether it is associated with an improvement in respiratory outcome. Read More

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December 2018

Decoupling environmental effects and host population dynamics for anthrax, a classic reservoir-driven disease.

PLoS One 2018 12;13(12):e0208621. Epub 2018 Dec 12.

Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, Florida, United States of America.

Quantitative models describing environmentally-mediated disease transmission rarely focus on the independent contribution of recruitment and the environment on the force of infection driving outbreaks. In this study we attempt to investigate the interaction between external factors and host's population dynamics in determining the outbreaks of some indirectly transmitted diseases. We first built deterministic and stochastic compartmental models based on anthrax which were parameterized using information from literature and complemented with field observations. Read More

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December 2018

Early-life environment and differences in costs of reproduction in a preindustrial human population.

PLoS One 2018 12;13(12):e0207236. Epub 2018 Dec 12.

Department of Biology, University of Turku, Turku, Finland.

Reproduction is predicted to trade-off with long-term maternal survival, but the survival costs often vary between individuals, cohorts and populations, limiting our understanding of this trade-off, which is central to life-history theory. One potential factor generating variation in reproductive costs is variation in developmental conditions, but the role of early-life environment in modifying the reproduction-survival trade-off has rarely been investigated. We quantified the effect of early-life environment on the trade-off between female reproduction and survival in pre-industrial humans by analysing individual-based life-history data for >80 birth cohorts collected from Finnish church records, and between-year variation in local crop yields, annual spring temperature, and infant mortality as proxies of early-life environment. Read More

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December 2018

Anemia at the time of delivery and its association with pregnancy outcomes: A study from a secondary care hospital in Haryana, India.

Indian J Public Health 2018 Oct-Dec;62(4):315-318

Assistant Professor, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.

Maternal anemia has been reportedly associated with increased risk of maternal and fetal morbidity and mortality. Adverse pregnancy outcomes such as preterm birth, low birth weight, and stillbirth have been reported to be associated with anemia. However, different studies have shown inconsistent results. Read More

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December 2018

Relationship between amikacin blood concentration and ototoxicity in low birth weight infants.

J Infect Chemother 2019 Jan 24;25(1):17-21. Epub 2018 Oct 24.

Department of Pharmacy, Yamanashi Prefectural Central Hospital, Yamanashi, 400-8506, Japan.

Amikacin (AMK) is used as empiric therapy for severe infections such as sepsis in low birth weight (LBW) infants. AMK administered once daily (OD) in adults is reported to be therapeutically effective and prevent side effects, however, evidence on AMK administration in LBW infants is limited, with no clear indications of effectiveness. We performed therapeutic drug monitoring analysis of 20 infants treated with AMK OD for severe infections such as bacteremia. Read More

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January 2019

Do immature and mature sibling oocytes recovered from stimulated cycles have the same reproductive potential?

Reprod Biomed Online 2018 Dec 6;37(6):667-676. Epub 2018 Oct 6.

IVF Laboratory, IVIRMA-Valencia, Valencia 46015, Spain; IVI Foundation, INCLIVA, Valencia 46026, Spain. Electronic address:

Research Question: How can laboratory and clinical outcomes of spontaneously, early maturing germinal-vesicle oocytes and sibling in-vivo-matured (metaphase II [MII]) oocytes be quantified and compared?

Design: A prospective, non-randomized intra-cohort study of oocytes from women aged 38 years or younger, with six or fewer MII oocytes and four or more germinal vesicles retrieved. No indication was identified for genetic tests or oocyte or embryo cryopreservation. The study was carried out at IVIRMA-Valencia. Read More

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December 2018

Testicular versus ejaculated spermatozoa for ICSI in patients without azoospermia: A systematic review.

Reprod Biomed Online 2018 Nov 6;37(5):573-580. Epub 2018 Oct 6.

Unit for Human Reproduction, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki Thessaloniki, Greece. Electronic address:

The use of testicular spermatozoa in men without azoospermia has been proposed as a means to increase the chances of pregnancy following assisted reproductive treatment. The purpose of this systematic review is to assess whether clinical outcomes are better when testicular rather than ejaculated spermatozoa are used for intracytoplasmic sperm injection in patients with abnormal semen parameters without azoospermia. A literature search identified four eligible studies out of 757 initially found. Read More

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November 2018

Factor X deficiency due to a compound heterozygosis between a new mutation (Gla72Asp) in exon 2 and an already known one (Gly154Arg) in exon 5: Factor X Mar del Plata 1).

Cardiovasc Hematol Disord Drug Targets 2018 Dec 11. Epub 2018 Dec 11.

Laboratorio de Hematologia, Sanatorio Allende y Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba. Argentina.

A compound heterozygote due to the association of a new mutation (Gla72Asp) with an already known mutation (Gly154Arg) of the FX gene is reported. The proposita is a 38 year old female who had a moderate bleeding tendency (menorrhagia, epistaxis, easy bruising). The proposita has never received substitution therapy but in the occasion of a uterine biopsy. Read More

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December 2018

Determination of Autoantibodies to Transglutaminase by Electrochemiluminescence (ECL) Assay.

Methods Mol Biol 2019 ;1901:197-203

Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, USA.

Appearance of autoantibodies to tissue transglutaminase (TGA) is the most reliable biomarker to identify celiac disease autoimmunity. A nonradioactive assay of determination of TGA was newly developed using electrochemiluminescence (ECL) technology. This ECL assay has been demonstrated to be more sensitive than current standard radio-binding assay (RBA) in detecting TGA and can detect TGA earlier among high-risk young children followed from birth. Read More

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January 2019

Previous Adverse Outcome of Term Pregnancy and Risk of Preterm Birth in Subsequent Pregnancy.

Matern Child Health J 2018 Dec 11. Epub 2018 Dec 11.

The California Preterm Birth Initiative, University of California, San Francisco, San Francisco, CA, USA.

Objective Evaluate risk of preterm birth (PTB, < 37 completed weeks' gestation) among a population of women in their second pregnancy with previous full term birth but other adverse pregnancy outcome. Methods The sample included singleton live born infants between 2007 and 2012 in a birth cohort file maintained by the California Office of Statewide Health Planning and Development. The sample was restricted to women with two pregnancies resulting in live born infants and first birth between 39 and 42 weeks' gestation. Read More

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December 2018

Adverse perinatal outcomes are associated with severe maternal morbidity and mortality: evidence from a national multicentre cross-sectional study.

Arch Gynecol Obstet 2018 Dec 11. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, School of Medicine, University of Campinas, Rua Alexander Fleming 101, Campinas, São Paulo, 13083-891, Brazil.

Purpose: To assess the association between maternal potentially life-threatening conditions (PLTC), maternal near miss (MNM), and maternal death (MD) with perinatal outcomes.

Methods: Cross-sectional study in 27 Brazilian referral centers from July, 2009 to June, 2010. All women presenting any criteria for PLTC and MNM, or MD, were included. Read More

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December 2018

Kyphectomy in neonates with meningomyelocele.

Childs Nerv Syst 2018 Dec 11. Epub 2018 Dec 11.

School of Medicine, Department of Neonatology, Celal Bayar University, Manisa, Turkey.

Purpose: Kyphosis is the most severe spinal deformity associated with meningomyelocele (MMC) and is seen in approximately 15% of neonates. Our purpose is to present our clinical experience, to discuss the technique and deformity correction in kyphectomy in neonates with MMC, and to assess its long-term outcomes.

Method: In this prospective study, the authors reviewed eight cases submitted to surgery between 2013 and 2015. Read More

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December 2018
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Impact of an In-House Pediatric Surgery Unit and Human Milk Centered Enteral Nutrition on Necrotizing Enterocolitis.

Biomed Res Int 2018 13;2018:5042707. Epub 2018 Nov 13.

EKO Children's Hospital, Oberhausen, Witten/Herdecke University, Germany.

The importance for mortality and morbidity of an in-house pediatric surgery unit for premature infants with necrotizing enterocolitis (NEC) remains undefined. Data on 389 consecutive very low birth weight infants with a birth weight <1250 g admitted between 2009 and 2014 was retrospectively analyzed in two almost identical neonatal intensive care units. Epidemiological data (n=172 and n=217, respectively) were comparable. Read More

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November 2018

Placental Circulation Intact Trial (PCI-T)-Resuscitation With the Placental Circulation Intact vs. Cord Milking for Very Preterm Infants: A Feasibility Study.

Front Pediatr 2018 27;6:364. Epub 2018 Nov 27.

Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital of Florence, Florence, Italy.

Preterm newborns receiving briefly delayed cord clamping or cord milking at birth have better neonatal outcomes. However, the time frame in which both these procedures are performed (< 60 s of life) is too short to explore the possible beneficial effects on early infant postnatal adaptation and outcomes of a prolonged transfusion strategy associated with neonatal respiration. We have designed a randomized, multicenter, controlled two-phase study: phase 1 to assess the feasibility of carrying out the protocol in a large randomized trial, and phase 2 to assess the efficacy of bedside assistance with intact placental circulation for 3 min in comparison to cord milking to improve outcome in the neonatal period; we present here the feasibility and safety phase of the study. Read More

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November 2018

A retrospective analysis of the follicle-stimulating hormone starting dose in expected normal responders undergoing their first fertilization cycle: proposed dose versus empiric dose.

Clin Exp Reprod Med 2018 Dec 30;45(4):183-188. Epub 2018 Nov 30.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Objective: The purpose of this retrospective study was to evaluate the appropriateness of various follicle-stimulating hormone (FSH) starting doses in expected normal responders based on the nomogram developed by La Marca et al.

Methods: A total of 117 first fertilization cycles performed from 2011 to 2017 were selected. All women were expected normal responders and used a recombinant FSH and flexible gonadotropin-releasing hormone antagonist protocol. Read More

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December 2018

Successful pregnancy after uterine artery embolization for uterine arterovenous malformation: a rare case report.

Int J Womens Health 2018 21;10:745-750. Epub 2018 Nov 21.

Università degli studi di Salerno - Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana", Salerno, Italy,

Objective: This paper reports on a rare case of pregnancy after uterine artery embolization (UAE) for uterine arteriovenous malformation (AVM). Debate exists about persistence of fertility in women after UAE. Adverse effects of this technique can modify both uterine echostructure, inducing necrosis and infarction, endometrial atrophy and uterine artery rupture, and ovarian reserve, causing persistent amenorrhea. Read More

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November 2018

Labor augmentation during birth and later cognitive ability in young adulthood.

Clin Epidemiol 2018 26;10:1765-1772. Epub 2018 Nov 26.

Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark,

Purpose: Synthetic oxytocin for labor augmentation during birth has been linked to negative neurodevelopment effects in children. We examined whether maternal labor augmentation was associated with lower cognitive ability in young adulthoods.

Patients And Methods: We identified 330,107 individuals (96. Read More

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November 2018

Slow growth and delayed maturation in a Critically Endangered insular flying fox ().

J Mammal 2018 Dec 21;99(6):1510-1521. Epub 2018 Sep 21.

The Hawkesbury institute for the Environment, Western Sydney University, Richmond, New South Wales, Australia.

Flying foxes (family Pteropodidae) have distinct life histories given their size, characterized by longevity, low reproductive output, and long gestation. However, they tend to decouple the age at which sexual maturity is reached from the age at which they reach adult dimensions. We examined growth, maturation, and reproduction in the Critically Endangered Christmas Island flying fox () to determine the timing of sex-specific life cycle events and patterns of growth. Read More

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December 2018

Postnatal induction of muscle fatty acid oxidation in mice differing in propensity to obesity: a role of pyruvate dehydrogenase.

Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Department of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.

Background/objective: Adaptation to the extrauterine environment depends on a switch from glycolysis to catabolism of fatty acids (FA) provided as milk lipids. We sought to learn whether the postnatal induction of muscle FA oxidation in mice could reflect propensity to obesity and to characterize the mechanisms controlling this induction.

Methods: Experiments were conducted using obesity-resistant A/J and obesity-prone C57BL/6J (B6) mice maintained at 30 °C, from 5 to 28 days after birth. Read More

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December 2018

The World Breastfeeding Trends Initiative: Implementation of the Global Strategy for Infant and Young Child Feeding in 84 countries.

J Public Health Policy 2018 Dec 11. Epub 2018 Dec 11.

IBFAN Africa, Pretoria, South Africa.

Breastfeeding could save the lives of more than 820,000 children and 20,000 women. Worldwide, despite evidence of the importance of both, only 42% women begin breastfeeding within an hour of birth, and 41% practice exclusive breastfeeding. In 2002, to mobilise action and support optimal breastfeeding, the World Health Assembly adopted the Global Strategy for Infant and Young Child Feeding. Read More

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December 2018

Neonatal intermittent hypoxemia events are associated with diagnosis of bronchopulmonary dysplasia at 36 weeks postmenstrual age.

Pediatr Res 2018 Dec 12. Epub 2018 Dec 12.

Division of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.

Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease and major pulmonary complication after premature birth. We have previously shown that increased intermittent hypoxemia (IH) events have been correlated to adverse outcomes and mortality in extremely premature infants. We hypothesize that early IH patterns are associated with the development of BPD. Read More

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December 2018

Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.

Proc Natl Acad Sci U S A 2018 Dec 11. Epub 2018 Dec 11.

Department of Genetics, St. Jude Children's Research Hospital, Memphis, TN 38105;

Frequent oxidative modification of the neural genome is a by-product of the high oxygen consumption of the nervous system. Rapid correction of oxidative DNA lesions is essential, as genome stability is a paramount determinant of neural homeostasis. Apurinic/apyrimidinic endonuclease 1 (APE1; also known as "APEX1" or "REF1") is a key enzyme for the repair of oxidative DNA damage, although the specific role(s) for this enzyme in the development and maintenance of the nervous system is largely unknown. Read More

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December 2018

GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells.

Blood Adv 2018 Dec;2(23):3553-3565

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD.

GATA2 deficiency is an inherited or sporadic genetic disorder characterized by distinct cellular deficiency, bone marrow failure, various infections, lymphedema, pulmonary alveolar proteinosis, and predisposition to myeloid malignancies resulting from heterozygous loss-of-function mutations in the gene. How heterozygous mutations affect human hematopoietic development or cause characteristic cellular deficiency and eventual hypoplastic myelodysplastic syndrome or leukemia is not fully understood. We used induced pluripotent stem cells (iPSCs) to study hematopoietic development in the setting of GATA2 deficiency. Read More

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December 2018

Validity of self-reported number of teeth in middle-aged Finnish adults: the Northern Finland Birth Cohort Study 1966.

BMC Oral Health 2018 Dec 11;18(1):210. Epub 2018 Dec 11.

Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, 90029, Oulu, Finland.

Background: We examined the validity of self-reported number of teeth in middle-aged adults by using representative cohort data to compare corresponding self-reported and clinical values.

Methods: This validity study is part of the representative 46-year-old follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966) Study. Mailed questionnaires (n = 5950) requested information on self-reported number of teeth and background variables (education, tooth brushing and smoking), while clinical oral health examinations (n = 1891) assessed the number of teeth (the 'gold standard'). Read More

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December 2018

Standardized outcome measures for pregnancy and childbirth, an ICHOM proposal.

BMC Health Serv Res 2018 Dec 11;18(1):953. Epub 2018 Dec 11.

International Consortium for Health Outcomes Measurement, Cambridge, MA, USA.

Background: Value-based health care aims to optimize the balance of patient outcomes and health care costs. To improve value in perinatal care using this strategy, standard outcomes must first be defined. The objective of this work was to define a minimum, internationally appropriate set of outcome measures for evaluating and improving perinatal care with a focus on outcomes that matter to women and their families. Read More

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December 2018

Maternal dietary consumption of legumes, vegetables and fruit during pregnancy, does it protect against small for gestational age?

BMC Pregnancy Childbirth 2018 Dec 11;18(1):486. Epub 2018 Dec 11.

Department of Health Sciences, University of Jaen, Campus de Las Lagunillas s n Edificio B3, 23071, Jaén, Spain.

Background: Different diets during pregnancy might have an impact on the health, reflected in the birthweight of newborns. The consumption of fruits and vegetables during pregnancy and the relationship with newborn health status have been studied by several authors. However, these studies have shown inconsistent results. Read More

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December 2018

Fatal postpartal dissection of all coronary arteries in an in vitro-fertilized woman.

J Cardiol Cases 2012 Apr 18;5(2):e73-e75. Epub 2012 Jan 18.

Service de Cardiologie, Hôpital Militaire de Tunis, Tunis, Tunisia.

Myocardial infarction complicates approximately 1 in 10,000 pregnancies [1]. Coronary artery dissection is the leading cause of pregnancy-related myocardial infarction during the postpartum period. Proposed etiologies include altered endocrine status, hemodynamic stress, eosinophilic inflammatory infiltrate, and disruption of vasa vasorum. Read More

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Systemic Arterial Hypertension in Childhood: A Challenge Related to the Increasing Survival of Very Low Birth Weight Preterm Infants.

Am J Perinatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Objective:  To verify the prevalence of systemic arterial hypertension (SAH) and to identify possible early predictors of SAH at ages 2 and 4 years in very low birth weight (VLBW) infants.

Study Design:  This is a prospective cohort study including inborn children with birth weight (BW) <1,500 g. Arterial blood pressure measurements were performed at 2 and 4 years. Read More

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December 2018

Prenatal thallium exposure and poor growth in early childhood: A prospective birth cohort study.

Environ Int 2018 Dec 8;123:224-230. Epub 2018 Dec 8.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, People's Republic of China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, People's Republic of China. Electronic address:

Background: Thallium (Tl) exposure remains a public health problem with potential impacts on humans. Studies have suggested that prenatal exposure to thallium may be associated with fetal growth, but no studies are known have explored its association with early childhood anthropometry.

Objective: To investigate the effects of prenatal Tl exposures on early child growth and development aged 0-2 years in a prospective birth cohort study. Read More

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December 2018

Brief reaching training with "sticky mittens" in preterm infants: Randomized controlled trial.

Hum Mov Sci 2018 Dec 8;63:138-147. Epub 2018 Dec 8.

Physical Therapy Section, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil. Electronic address:

Objective: To examine whether a brief reaching training with sticky mittens was effective to improve reaching behavior in newly reaching preterm infants.

Methods: In this randomized controlled trial, twenty four 5-month-old (±16-week-old corrected age) preterm infants were randomly allocated into experimental or control groups. Infants were assessed three times in a single session: pretraining (immediately before training), posttraining (immediately after training), and retention (4 min after the posttraining). Read More

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December 2018

Impact of maternal low-level cadmium exposure on glucose and lipid metabolism of the litter at different ages after weaning.

Chemosphere 2018 Nov 26;219:109-121. Epub 2018 Nov 26.

Univ. Grenoble Alpes, Inserm U1055, LBFA, 38000 Grenoble, France. Electronic address:

Cadmium (Cd) is a metal which may participate in the development of type II diabetes even if Cd exposure levels are mild. However, experimental studies focusing on daily environmentally relevant doses are scarce, particularly for glucose metabolism of the offspring of chronically exposed mothers. The aim is to measure the impact of maternal low level Cd exposure on glucose and lipid metabolism of offspring. Read More

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November 2018

Cross-border and domestic surrogacy in the UK context: an exploration of practical and legal decision-making.

Hum Fertil (Camb) 2018 Dec 11:1-12. Epub 2018 Dec 11.

b NGA Law and Brilliant Beginnings , London , UK.

This study aimed to explore UK intending parent's reasons for cross-border and domestic surrogacy, their preparations for the birth and the practical and legal challenges faced after the birth. An online survey was completed by 203 participants, of which 132 had a child born through surrogacy, 33 were in the process of surrogacy and 38 were planning a surrogacy arrangement. The most common reason for pursuing surrogacy in the UK was wanting a relationship with the surrogate (43%; n = 17) and for conducting surrogacy in the USA was because of a better legal framework (97%; n = 60). Read More

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December 2018

Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle-aged Caucasians: the Northern Finland Birth Cohort Eye study.

Acta Ophthalmol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.

Purpose: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle-aged Caucasians.

Methods: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured in the right eye using a semi-automated computer-assisted program. Read More

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December 2018
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Review shows that thyroid hormone substitution could benefit transient hypothyroxinaemia of prematurity but treatment strategies need to be clarified.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Neonatology, University Hospitals Leuven, KU, Leuven, Belgium.

Aim: Thyroid hormones are crucial for fetal and neonatal brain development. This paper provides an overview of the normal role of thyroid hormones in fetal brain development and the pathophysiology of transient hypothyroxinaemia of prematurity (THOP). It also discusses the diagnostic and therapeutic controversies around THOP and looks at directions for future research. Read More

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December 2018

Aerodigestive and communicative behaviors in anencephalic and hydranencephalic infants.

Birth Defects Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Linguistics, University of British Columbia, Vancouver, Canada.

The aerodigestive and communicative behaviors of anencephalic and hydranencephalic patients are assessed from literature sources and are compared with documented neural structures present in the brainstem, subcortical, and cortical regions of the brain. Much of the data analyzed corroborate previous neurological studies, which focus on central pattern generators and development in model organisms. However, findings suggest that further research is necessary to determine which components of these systems support these behaviors. Read More

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December 2018

Developmental defects of enamel in the deciduous incisors of infants born preterm: prospective cohort.

Oral Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Oral Health, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Objective: Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake, and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants.

Subjects And Methods: In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Read More

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December 2018

Trends and state variations in out-of-hospital births in the United States, 2004-2017.

Birth 2018 Dec 10. Epub 2018 Dec 10.

Community Health Sciences Department, Boston University School of Public Health, Boston, Massachusetts.

Background: Out-of-hospital births have been increasing in the United States, although past studies have found wide variations between states. Our purpose was to examine trends in out-of-hospital births, the risk profile of these births, and state differences in women's access to these births.

Methods: National birth certificate data from 2004 to 2017 were analyzed. Read More

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December 2018

Incidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital.

J Obstet Gynaecol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aim: To obtain the incidence of preterm premature rupture of membranes (PPROM) at Siriraj Hospital during 2012-2016 and to identify its possible risk factors in singleton pregnancies.

Methods: This study was a retrospective case-control study. The institutional ethical committee has approved the study. Read More

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December 2018

Anaemia in pregnancy among Aboriginal and Torres Strait Islander women of Far North Queensland: A retrospective cohort study.

Nutr Diet 2018 Nov;75(5):457-467

Centre for Chronic Disease Prevention, Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, Queensland, Australia.

Aim: Anaemia during pregnancy is common worldwide. In Australia between 7.1% and 11% of mothers have been reported to have anaemia in pregnancy. Read More

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November 2018
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Iron-fortified formula use in young children and association with socioeconomic factors in the French nationwide ELFE cohort.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Inserm, UMR1153, Centre de Recherche en Épidémiologie et Statistique Sorbonne Paris Cité (CRESS), équipe Épidémiologie Périnatale, Obstétricale et Pédiatrique (ÉPOPé) Labex GR-Ex, Paris, France.

Sacri A-S, de Lauzon-Guillain B, Dufourg M-D, Bois C, Charles M A, Chalumeau M. Iron-fortified formula use in young children and association with socioeconomic factors in the French nationwide ELFE cohort.

Aim: To study the rate of iron-fortified infant formula (IFF) use in young children in France and its association with socioeconomic factors. Read More

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December 2018

Model that predicted death or disabilities in premature infants was valid at seven years of age.

Acta Paediatr 2018 Dec 8. Epub 2018 Dec 8.

Neonatologist. 12 de Octubre University Hospital, Madrid, Spain.

Aim: Validated a model that used bronchopulmonary dysplasia (BPD), brain injuries measured using ultrasound and retinopathy of prematurity (ROP) to predict late death or disability in premature infants at seven years of age.

Methods: A retrospective study was performed at the 12 de Octubre Hospital neonatal unit in Madrid. A logistic model was applied to estimate the independent prognostic contribution of each morbidity and the effect that the combination of morbidities had on the seven-year outcomes. Read More

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December 2018

Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: waning and association with self-reported severity and duration of illness.

Influenza Other Respir Viruses 2018 Dec 9. Epub 2018 Dec 9.

Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, 0213, Oslo, Norway.

Background: A population-based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy.

Objectives: We studied maternal A(H1N1)pdm09-specific hemagglutination inhibition (HI)-titer levels and waning in women with influenza-like illness (ILI) in pregnancy compared to vaccinated women. Moreover, we studied the association between HI-titers and self-reported severity and duration of ILI. Read More

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December 2018

We need to treat pregnant women as adults: Women should be consented for an attempt at normal vaginal birth as for operative delivery, with risks and potential complications explained.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):701-703

Sydney Law School, University of Sydney, Sydney, New South Wales, Australia.

Since the mid-90s, Australian law has required doctors to disclose material risks of proposed treatment. Medical practitioners have had two decades to adapt, and, by and large, patient autonomy is acknowledged and respected by obtaining 'informed consent'. While problems with obtaining consent do surface in medico-legal litigation, practitioners are generally aware of the need to do so and usually comply with requirements. Read More

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December 2018

Vaginal delivery: An argument against requiring consent.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):704-706

ANU Medical School, ANU College of Health and Medicine, Canberra, Australian Capital Territory, Australia.

Birth by vaginal delivery is an evolutionary process refined over millennia to create a sustainable and safe method of human reproduction. A key argument against requiring consent for vaginal birth acknowledges that from an evolutionary point of view, vaginal delivery has successfully accompanied human development and remains the natural and default form of human birth. Concern has been raised by the Montgomery court case in the United Kingdom; however, the ruling does not mean consent is required for normal birth. Read More

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December 2018