340,900 results match your criteria Birth: Issues in Perinatal Care [Journal]


Glucocorticoids and programming of the microenvironment in heart.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

L Zhang, Basic Sciences, Loma Linda University School of Medicine, Loma Linda, United States.

Glucocorticoids are primary stress hormones and can improve neonatal survival when given to pregnant women threatened by preterm birth or to preterm infants. It has become increasingly apparent that glucocorticoids, primarily through interacting with glucocorticoid receptors, play a critical role in late gestational cardiac maturation. Altered glucocorticoid actions contribute to the development and progression of heart disease. Read More

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http://dx.doi.org/10.1530/JOE-18-0672DOI Listing

Inherited risk plus prenatal insult caused malignant dysfunction in mesenteric arteries in adolescent SHR offspring.

PLoS One 2019 24;14(4):e0215994. Epub 2019 Apr 24.

Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China.

Prenatal hypoxia can induce cardiovascular diseases in the offspring. This study determined whether and how prenatal hypoxia may cause malignant hypertension and impaired vascular functions in spontaneous hypertension rat (SHR) offspring at adolescent stage. Pregnant SHR were placed in a hypoxic chamber (11% O2) or normal environment (21% O2) from gestational day 6 until birth. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215994PLOS

Socioeconomic inequality and determinants of postnatal home visits made by public health midwives: An analysis of the Sri Lanka Demographic and Health Survey.

PLoS One 2019 24;14(4):e0215816. Epub 2019 Apr 24.

Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.

Introduction: The impact of socioeconomic inequalities on health outcomes and service delivery is increasingly researched globally. This study assessed the overall and sector-wise socioeconomic inequality in postnatal home visits made by Public Health Midwives (PHMs) in Sri Lanka and decomposed the observed socioeconomic inequality into potential determinants.

Methods: Data from the Sri Lanka Demographic and Health Survey (SLDHS) 2006-07 were used. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215816PLOS

Adaptation of the Childbirth Experience Questionnaire (CEQ) in China: A multisite cross-sectional study.

PLoS One 2019 24;14(4):e0215373. Epub 2019 Apr 24.

Chinese Maternal and Child Health Association, Beijing, China.

Background: The childbirth experience of women represents a significant aspect of quality care. Due to the lack of a reliable Chinese language tool for assessing childbirth experiences, examples must be adapted from other countries. The aim of this study was to translate an English version of the Childbirth Experience Questionnaire (CEQ) into Chinese and adapt this tool to the Chinese context. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215373PLOS
April 2019
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Perinatal hepatitis B virus transmission in Lao PDR: A prospective cohort study.

PLoS One 2019 24;14(4):e0215011. Epub 2019 Apr 24.

Institut de recherche pour le développement (IRD, France), PHPT, Changklan, Muang, Chiang Mai, Thailand.

Background: Mother-to-child transmission of hepatitis B virus (HBV) is the main cause of new infections worldwide. We aimed at assessing the percentage of infants successfully immunized in two major hospitals in Vientiane, Lao PDR where HB immune globulin (HBIg) is not available.

Methods: We studied a prospective cohort of chronically HBV infected pregnant women and their infants until 6 months post-partum from January 2015 to March 2017. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215011PLOS
April 2019
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Exploring the power of bayesian birth-death skyline models to detect mass extinction events from phylogenies with only extant taxa.

Evolution 2019 Apr 24. Epub 2019 Apr 24.

Real Jardín Botánico (RJB), CSIC, Plaza de Murillo 2, 28014, Madrid, Spain.

Mass extinction events (MEEs), defined as significant losses of species diversity in significantly short time periods, have attracted the attention of biologists because of their link to major environmental change. MEEs have traditionally been studied through the fossil record, but the development of birth-death models has made it possible to detect their signature based on extant-taxa phylogenies. Most birth-death models consider MEEs as instantaneous events where a high proportion of species are simultaneously removed from the tree ("single pulse" approach), in contrast to the paleontological record, where MEEs have a time-duration. Read More

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http://dx.doi.org/10.1111/evo.13753DOI Listing

Should we treat every infant with a probiotic?

Authors:
Mark A Underwood

Minerva Pediatr 2019 Jun;71(3):253-262

Division of Neonatology, University of California Davis, Sacramento, CA, USA -

Intestinal dysbiosis is associated with a long list of both acute and chronic inflammatory diseases and appears to be increasing in developed countries over the last century with the introduction of antibiotics, changes in sanitation, formula feeding and cesarean sections. The evidence supporting prophylactic administration of probiotic microbes to very preterm infants for the prevention of necrotizing enterocolitis, late onset sepsis and death is strong. The evidence for benefit of probiotics in infantile colic is strong but limited to the L. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05526-9DOI Listing

Neonate with annular erythema on his face and scalp at birth.

Authors:

J Paediatr Child Health 2019 May;55(5):605-606

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http://dx.doi.org/10.1111/jpc.2_14424DOI Listing

Neonate with annular erythema on his face and scalp at birth.

J Paediatr Child Health 2019 May;55(5):604-605

Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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http://dx.doi.org/10.1111/jpc.1_14424DOI Listing

Correlating Infant Faecal Microbiota Composition and Human Milk Oligosaccharide Consumption by Microbiota of One-Month Old Breastfed Infants.

Mol Nutr Food Res 2019 Apr 24:e1801214. Epub 2019 Apr 24.

K. Borewicz, H. Smidt, Laboratory of Microbiology, Wageningen University & Research, Stippeneng 4, 6708 WE, Wageningen, the Netherlands.

Scope: Understanding biological functions of different free human milk oligosaccharides (HMOs) in shaping gastrointestinal tract microbiota during infancy is of great interest. We examined a link between HMOs in maternal milk and infant faecal microbiota composition and investigated the role of microbiota in degrading HMOs within the GI tract of healthy, breastfed, one-month old infants.

Methods And Results: Maternal breast milk and corresponding infant faeces originated from the KOALA Birth Cohort. Read More

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http://dx.doi.org/10.1002/mnfr.201801214DOI Listing

Parents' journey caring for a preterm infant until discharge from hospital based neonatal home care - a challenging process to cope with.

J Clin Nurs 2019 Apr 24. Epub 2019 Apr 24.

Department of Health Sciences, Faculty of Medicine, Lund University, Sweden.

Aims And Objectives: To present parents' lived experience of having a preterm infant cared for at the neonatal unit until discharge from hospital-based neonatal home care (HNHC).

Background: Becoming a parent to a preterm infant has been reported as an experience that may influence the parent's lifeworld also after discharge. Interventions have been implemented at the NICUs, e. Read More

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http://dx.doi.org/10.1111/jocn.14891DOI Listing

The Labor Progression Study (LaPS): The use of oxytocin augmentation during labor following Zhang's guideline and the WHO partograph in a cluster randomized trial.

Acta Obstet Gynecol Scand 2019 Apr 24. Epub 2019 Apr 24.

Department of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway.

Introduction: This study aims to investigate the use of oxytocin augmentation during labor in nulliparous women following Zhang's guideline or the WHO partograph.

Material And Methods: This is a secondary analysis of a cluster randomized controlled trial in 14 birth care units in Norway, randomly assigned to either the intervention group, which followed Zhang's guideline, or to the control group, which followed the WHO partograph, for labor progression. The participants were nulliparous women who had a singleton full-term fetus in a cephalic presentation and spontaneous onset of labor, denoted as group 1 in the Ten Group Classification System. Read More

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http://dx.doi.org/10.1111/aogs.13629DOI Listing
April 2019
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Mercury exposure of children living in Amazonian villages: influence of geographical location where they lived during prenatal and postnatal development.

An Acad Bras Cienc 2019 18;91(suppl 1):e20180097. Epub 2019 Apr 18.

Núcleo de Medicina Tropical, Universidade Federal do Pará, Avenida Generalíssimo Deodoro, 92, Umarizal, 66055-240 Belém, PA, Brazil.

Introduction: In some Amazonian river basins, hair mercury concentration is above the recommended levels. We evaluated the influence of birth geographical location in the hair mercury level of Amazonian riverine children.

Materials And Methods: Hair mercury concentration was measured in 219 children living in four Amazonian riverine communities: Tapajós River (São Luiz do Tapajós and Barreiras villages, n = 110), Tocantins River (Limoeiro do Ajurú village, n = 61), and Caeté River (Caratateua village, n = 48). Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0001-3765201920180097DOI Listing
April 2019
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Caesarean section improves neonatal outcomes only from 24 + 0 weeks for periviable breech but not for cephalic infants.

J Matern Fetal Neonatal Med 2019 Apr 24:1-11. Epub 2019 Apr 24.

a Mater Research Institute , University of Queensland , , South Brisbane, Australia.

Background: Although caesarean delivery at periviable gestations may minimise birth trauma it may not necessarily improve perinatal outcomes. The aim of this study was to assess the impact of mode of birth on outcomes for breech versus cephalic presentation at 22 + 0-25 + 6 weeks.

Methods: Retrospective study of single, nonanomalous infants at 22 + 0-25 + 6 weeks gestation born at a tertiary centre in Australia. Read More

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http://dx.doi.org/10.1080/14767058.2019.1611765DOI Listing

Trends in obstetric policies in cases of failed vacuum extraction in Japan.

J Matern Fetal Neonatal Med 2019 Apr 24:1-11. Epub 2019 Apr 24.

a Department of Obstetrics and Gynecology , Japanese Red Cross Katsushika Maternity Hospital , Tokyo.

Objective: In April 2008, the guidelines for obstetric practice in Japan have made the following recommendations: (1) do not use vacuum extraction (VE) for more than 20 minutes, and consider forceps delivery (FD) or an emergency cesarean section (CS) if necessary (20-minute VE trial rule), and (2) do not try VE more than 5 times, even if VE has been used for less than 20 minutes (5-time VE trial rule). The aims of the present study were to compare the obstetric policies related to failed VE before and after 2008.

Methods: We reviewed the obstetric records of all cases of VE in cases of singleton pregnancy with a neonatal birth weight ≥ 2500 g beyond 37 weeks' gestation at our hospital from April 2002 to March 2014. Read More

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http://dx.doi.org/10.1080/14767058.2019.1611767DOI Listing

Safe and sustained expression of human iduronidase after adeno-associated virus 9 intrathecal administration in infant rhesus monkeys.

Hum Gene Ther 2019 Apr 24. Epub 2019 Apr 24.

University of Pennsylvania, Gene Therapy Program , Suite 2000 TRL , 125 S. 31st Street , Philadelphia, Pennsylvania, United States , 19104.

Many neuropathic diseases cause early, irreversible neurologic deterioration, which warrants therapeutic intervention during the first months of life. In the case of mucopolysaccharidosis type I (MPS I), a recessive lysosomal storage disorder that results from a deficiency of the lysosomal enzyme, α-l-iduronidase (IDUA), one of the most promising treatment approaches is to restore enzyme expression through gene therapy. Specifically, administering neurotropic adeno-associated virus (AAV) encoding IDUA into the cerebrospinal fluid (CSF) via suboccipital administration has demonstrated remarkable efficacy in large animals. Read More

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http://dx.doi.org/10.1089/hum.2019.012DOI Listing

Expanding the phenotype for the recurrent p.Ala391Glu variant in FGFR3: Beyond crouzon syndrome and acanthosis nigricans.

Mol Genet Genomic Med 2019 Apr 23:e656. Epub 2019 Apr 23.

Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia.

Background: Craniosynostosis, or premature fusion of the skull sutures, is a group of disorders that can present in isolation (nonsyndromic) or be associated with other anomalies (syndromic). Delineation of syndromic craniosynostosis is confounded due to phenotypic overlap, variable expression as well as molecular heterogeneity. We report on an infant who presented at birth with multisuture synostosis, turribrachycephaly, midface hypoplasia, beaked nose, low set ears, a high palate and short squat appearing thumbs, and great toes without deviation. Read More

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http://dx.doi.org/10.1002/mgg3.656DOI Listing

Two novel ANK1 loss-of-function mutations in Chinese families with hereditary spherocytosis.

J Cell Mol Med 2019 Apr 23. Epub 2019 Apr 23.

Pediatrics Research Institute, Children's Hospital of Fudan University, Shanghai, China.

Hereditary spherocytosis (HS) is the most common inherited haemolytic anaemia disorder. ANK1 mutations account for most HS cases, but pathogenicity analysis and functional research have not been widely performed for these mutations. In this study, in order to confirm diagnosis, gene mutation was screened in two unrelated Chinese families with HS by a next-generation sequencing (NGS) panel and then confirmed by Sanger sequencing. Read More

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http://dx.doi.org/10.1111/jcmm.14343DOI Listing

Neurofibromatosis type 1 of the child increases birth weight.

Am J Med Genet A 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatology and Venereology, University of Turku, Turku, Finland.

Neurofibromatosis type 1 (NF1) is associated with reduced adult height, but there are no cohort studies on birth size. This retrospective study includes a cohort of 1,410 persons with NF1 and a matched comparison cohort from the general population. Figures for birth size were retrieved from the administrative registers of Finland, and the data were converted to standard deviation scores (SDS), defined as standard deviation difference to the reference population. Read More

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http://dx.doi.org/10.1002/ajmg.a.61161DOI Listing

The association between newborn screening analytes and childhood autism in a Texas Medicaid population, 2010-2012.

Am J Med Genet B Neuropsychiatr Genet 2019 Apr 24. Epub 2019 Apr 24.

Environmental Epidemiology and Disease Registries Section, Texas Department of State Health Services, Austin, Texas.

Autism (or autism spectrum disorder [ASD]) is an often disabling childhood neurologic condition of mostly unknown cause. It is commonly diagnosed at 3 or 4 years of age. We explored whether there was an association of any analytes measured by newborn screening tests with a later diagnosis of ASD. Read More

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http://dx.doi.org/10.1002/ajmg.b.32728DOI Listing

Internal podalic version for delivery of high floating head during cesarean section and neonatal outcome.

J Obstet Gynaecol Res 2019 Apr 24. Epub 2019 Apr 24.

Department of Pediatrics and Neonatology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Aim: To evaluate the technique of internal podalic version for delivery of high floating head during cesarean section as an alternative for other methods for its delivery and its effects on neonatal outcome.

Methods: This study used clinical randomized controlled study design. Three groups of patients each group has 50 patients who attended for elective cesarean section and found to have high floating head during operation, Group I: the babies were delivered by internal podalic version. Read More

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http://dx.doi.org/10.1111/jog.13979DOI Listing

Exposure to caring parenting and adult mental health in extremely low birthweight survivors.

J Paediatr Child Health 2019 Apr 23. Epub 2019 Apr 23.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.

Aim: Individuals born at extremely low birthweight (ELBW; <1000 g) are exposed to early adversities that increase the risk of mental health problems in later life. Caring parenting has been shown to offset the negative effects of early adversity in general population samples. However, the long-term impact of caring parenting on the mental health of preterm survivors in adulthood is not known. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jpc.14476
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http://dx.doi.org/10.1111/jpc.14476DOI Listing
April 2019
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Weight trajectories and disordered eating behaviours in 11- to 12-year-olds: A longitudinal study within the Danish National Birth Cohort.

Eur Eat Disord Rev 2019 Apr 23. Epub 2019 Apr 23.

Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Objective: To examine how childhood weight trajectories are associated with disordered eating behaviours (DEBs) in early adolescence.

Methods: Self-reports on DEBs (fasting, purging, and binge eating) were obtained from 18,337 children in the 11-year follow-up of the Danish National Birth Cohort. For this population, birth register information on gestational age and birth weight was categorized into the following: small, appropriate, and large for gestational age. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/erv.2680
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http://dx.doi.org/10.1002/erv.2680DOI Listing
April 2019
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Factors associated with women's desire for control of healthcare during childbirth: Psychometric analysis and construct validation.

Res Nurs Health 2019 Apr 23. Epub 2019 Apr 23.

Department of Psychology, University of Kansas, Lawrence, Kansas.

The desire for control of healthcare is a significant moderator of outcomes related to childbirth. Researchers have shown that a sense of control of healthcare during childbirth is strongly correlated with postpartum maternal well-being. The aims of this study were to examine (a) the psychometric characteristics of an instrument to assess women's desire for control of healthcare during childbirth, and (b) examine desire for control in relation to parity, medical complications of pregnancy, and women's choices of childbirth providers and setting. Read More

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http://dx.doi.org/10.1002/nur.21948DOI Listing

Integration of Traditional Birth Attendants into Mental Healthcare: A Multistakeholder Qualitative Study Exploration.

Biomed Res Int 2019 21;2019:8195267. Epub 2019 Mar 21.

Africa Mental Health Research and Training Foundation, Nairobi, Kenya.

Background: A significant number of people with common mental disorders are undiagnosed or undetected at primary healthcare facilities. The experience of traditional birth attendants (TBAs) in reassuring perinatal mothers could be utilized in maternal mental healthcare. The aim of this study was to gain insight into the feasibility of integrating TBAs into maternal mental healthcare using multiple stakeholder views. Read More

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http://dx.doi.org/10.1155/2019/8195267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448332PMC

Evaluation of Changes in Insulin Sensitivity in Prepubertal Small for Gestational Age Children Treated with Growth Hormone.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):14-21

Department of Pediatric Endocrinology, Dr. von Haunersches Children's Hospital, Ludwig-Maximilian-University of Munich, Lindwurmstr, Munich, Germany.

Background: Although growth hormone (GH) therapy for children born small for gestational age (SGA) has been approved for many years, there are still concerns about increasing their risk for insulin resistance and diabetes mellitus type 2. Monitoring of glucose homeostasis is therefore generally recommended, but there is no consensus on either the methods or consequences.

Methods And Aims: The aim of our study was to analyze the oral Glucose Tolerance Tests (oGTTs) which were performed yearly from baseline to 4 years of GH therapy in a collective of 93 SGA children, who were prepubertal during the whole follow-up. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_91_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446669PMC

Stretched Penile Length and Testicular Size from Birth to 18 Years in Boys from Western Maharashtra.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):3-8

Department of Growth and Pediatric Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.

Background: Genital stage and testicular volume examination and assessment are essential for assessment of growth puberty in boys. There is paucity of Indian data for penile and testicular parameters particularly in pubertal years.

Aim: The aim of this study is to present normative data for penile length, testicular volume, and testicular length from birth to 18 years in boys from western Maharashtra and to correlate these parameters with sexual maturity staging (SMR) (Tanner staging). Read More

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http://dx.doi.org/10.4103/ijem.IJEM_242_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446671PMC

A novel compound heterozygous variant of identified in a Japanese patient with Leigh syndrome.

Hum Genome Var 2019 19;6:19. Epub 2019 Apr 19.

1Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.

Leigh syndrome (LS) is a heterogeneous neurodegenerative disorder caused by mitochondrial dysfunction. Certain LS cases have mutations in , which encodes a short-chain enoyl-CoA hydratase involved in the metabolism of fatty acids and branched-chain amino acids in mitochondria. Using exome sequencing, we diagnosed a Japanese patient with LS and identified the patient as a compound heterozygote for a novel variant of , consisting of NM_004092. Read More

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http://dx.doi.org/10.1038/s41439-019-0050-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474858PMC

Profile of HBV Integration in the Plasma DNA of Hepatocellular Carcinoma Patients.

Curr Genomics 2019 Jan;20(1):61-68

1Jining Medical University, Jining, Shandong272067, China; 2Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, Shandong272067, China; 3Southern University of Science and Technology, Shenzhen518055, China; 4Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen518002, China; 5Center for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA; 6BGI College, University of Chinese Academy of Sciences, Shenzhen518083, China.

Background: Hepatitis B Viral (HBV) infection is one of the major causes of Hepatocellular Carcinoma (HCC). Mounting evidence had provided that the HBV integration might be a critical con-tributor of HCC carcinogenesis.

Objective And Methods: To explore the profile of HBV integration in the plasma DNA, the method of next-generation sequencing, HBV capture and bioinformatics had been employed to screen for HBV in-tegration sites in the plasma samples. Read More

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http://dx.doi.org/10.2174/1389202919666181002144336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446477PMC
January 2019

Effects of dietary arginine supplementation in pregnant mares on maternal metabolism, placental structure and function and foal growth.

Sci Rep 2019 Apr 23;9(1):6461. Epub 2019 Apr 23.

UMR BDR, INRA, ENVA, Université Paris Saclay, 78350 Jouy en Josas, France.

Foals born to primiparous mares are lighter and less mature than those born to multiparous dams. Factors driving this difference are not totally understood. Using 7 multiparous and 6 primiparous standardbred mares, we demonstrated that, in late gestation, primiparous mares were less insulin resistant compared to multiparous mares, and that their foals had reduced plasma amino-acid concentrations at birth compared to foals born to multiparous mares. Read More

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http://dx.doi.org/10.1038/s41598-019-42941-0DOI Listing

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Authors:
Leanne K Küpers Claire Monnereau Gemma C Sharp Paul Yousefi Lucas A Salas Akram Ghantous Christian M Page Sarah E Reese Allen J Wilcox Darina Czamara Anne P Starling Alexei Novoloaca Samantha Lent Ritu Roy Cathrine Hoyo Carrie V Breton Catherine Allard Allan C Just Kelly M Bakulski John W Holloway Todd M Everson Cheng-Jian Xu Rae-Chi Huang Diana A van der Plaat Matthias Wielscher Simon Kebede Merid Vilhelmina Ullemar Faisal I Rezwan Jari Lahti Jenny van Dongen Sabine A S Langie Tom G Richardson Maria C Magnus Ellen A Nohr Zongli Xu Liesbeth Duijts Shanshan Zhao Weiming Zhang Michelle Plusquin Dawn L DeMeo Olivia Solomon Joosje H Heimovaara Dereje D Jima Lu Gao Mariona Bustamante Patrice Perron Robert O Wright Irva Hertz-Picciotto Hongmei Zhang Margaret R Karagas Ulrike Gehring Carmen J Marsit Lawrence J Beilin Judith M Vonk Marjo-Riitta Jarvelin Anna Bergström Anne K Örtqvist Susan Ewart Pia M Villa Sophie E Moore Gonneke Willemsen Arnout R L Standaert Siri E Håberg Thorkild I A Sørensen Jack A Taylor Katri Räikkönen Ivana V Yang Katerina Kechris Tim S Nawrot Matt J Silver Yun Yun Gong Lorenzo Richiardi Manolis Kogevinas Augusto A Litonjua Brenda Eskenazi Karen Huen Hamdi Mbarek Rachel L Maguire Terence Dwyer Martine Vrijheid Luigi Bouchard Andrea A Baccarelli Lisa A Croen Wilfried Karmaus Denise Anderson Maaike de Vries Sylvain Sebert Juha Kere Robert Karlsson Syed Hasan Arshad Esa Hämäläinen Michael N Routledge Dorret I Boomsma Andrew P Feinberg Craig J Newschaffer Eva Govarts Matthieu Moisse M Daniele Fallin Erik Melén Andrew M Prentice Eero Kajantie Catarina Almqvist Emily Oken Dana Dabelea H Marike Boezen Phillip E Melton Rosalind J Wright Gerard H Koppelman Letizia Trevisi Marie-France Hivert Jordi Sunyer Monica C Munthe-Kaas Susan K Murphy Eva Corpeleijn Joseph Wiemels Nina Holland Zdenko Herceg Elisabeth B Binder George Davey Smith Vincent W V Jaddoe Rolv T Lie Wenche Nystad Stephanie J London Debbie A Lawlor Caroline L Relton Harold Snieder Janine F Felix

Nat Commun 2019 Apr 23;10(1):1893. Epub 2019 Apr 23.

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P < 1.06 x 10). Read More

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http://dx.doi.org/10.1038/s41467-019-09671-3DOI Listing

Immunization in pregnancy safety surveillance in low and middle-income countries- field performance and validation of novel case definitions.

Vaccine 2019 Apr 20. Epub 2019 Apr 20.

Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; African Leadership in Vaccinology Expertise (ALIVE), Faculty of Health Science, University of the Witwatersrand, South Africa.

Background: A globally standardized approach in high and low and middle-income countries (LMIC) to actively monitor the safety of vaccines for pregnant women during development and implementation phases is critical. Brighton Collaboration's (BC) Global Alignment of Immunization Safety Assessment in Pregnancy (GAIA) project has developed globally standardized case definitions (CDs) of key obstetric and neonatal terms for the assessment of safety of vaccines in pregnancy. CDs are categorized into levels of diagnostic certainty, facilitating their use in varied settings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193042
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http://dx.doi.org/10.1016/j.vaccine.2019.03.074DOI Listing
April 2019
1 Read

Increased expression of YAP is associated with decreased cell autophagy in the eutopic endometrial stromal cells of endometriosis.

Mol Cell Endocrinol 2019 Apr 20. Epub 2019 Apr 20.

Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China. Electronic address:

Basic research has shown that signal pathways play significant roles in the development and progression of endometriosis (EMS). We first reported that the Hippo-YAP (Yes-associated protein) pathway promotes cell proliferation and anti-apoptosis in endometrial stromal cells (ESCs) of EMS. Cell autophagy has been found to be involved in the endometrial regulation and the pathophysiology of EMS. Read More

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http://dx.doi.org/10.1016/j.mce.2019.04.012DOI Listing

Fetal Exposure to high levels of Maternal Glucocorticoids Alters Reelin Signaling in The Prefrontal Cortex of Rat Pups.

Int J Dev Neurosci 2019 Apr 20. Epub 2019 Apr 20.

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakornpathom, Thailand. Electronic address:

Maternal stress (MS) is associated with various neuropsychiatric disorders and cognitive impairment in the offspring. However, it is unclear how early life stress alters the pup's brain development and how it contributes to the pathology of neuropsychiatric disorders later in life. Reelin is a large extracellular matrix glycoprotein that plays essential roles in early brain development such as neural migration, synaptic development, and maturation. Read More

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http://dx.doi.org/10.1016/j.ijdevneu.2019.04.004DOI Listing

Asymmetry of Retinopathy of Prematurity Border in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity Study.

Ophthalmol Retina 2019 Mar 9;3(3):278-284. Epub 2018 Oct 9.

Division of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Purpose: To measure the location of the retinopathy of prematurity (ROP) border in a sample of premature infants developed ROP and to determine the location for predicting subsequent development of referral-warranted ROP (defined as stage 3 ROP, zone I ROP, or plus disease) or treated ROP.

Design: Secondary analysis of data from an observational cohort study, the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity study.

Participants: Infants with birth weight (BW) of less than 1251 g with at least 1 examination and imaging session at 34 weeks postmenstrual age (PMA) or younger with ROP not meeting referral-warranted ROP and at least 1 subsequent examination at 36 weeks PMA or older. Read More

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http://dx.doi.org/10.1016/j.oret.2018.10.003DOI Listing

[Etiology and genetic diagnosis of short stature in children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Apr;21(4):381-386

Graduate School of Hebei Medical University, Shijiazhuang 050017, China.

Objective: To study the etiology and genetic diagnosis of children with short stature.

Methods: A retrospective analysis was performed to study the etiological distribution and clinical features of 86 children with short stature.

Results: A total of 6 causes were observed in these children, among which idiopathic short stature (ISS, 41%) and growth hormone deficiency (GHD, 29%) were the most common causes, followed by genetic diseases (14%). Read More

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[Association of exposure to polycyclic aromatic hydrocarbons during pregnancy with autism spectrum disorder-related behaviors in toddlers: a birth cohort study].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Apr;21(4):332-336

Qingdao University, Qingdao, Shandong 266071, China.

Objective: To study the association of exposure to polycyclic aromatic hydrocarbons (PAH) during pregnancy and autism spectrum disorder (ASD)-related behaviors in toddlers.

Methods: A total of 348 toddlers who had accepted the measurement of PAH-DNA adduct in umbilical cord blood and evaluation of behavior problems at the age of 36 months were enrolled in this birth cohort study. Child Behavior Checklist (CBCL) and Autism Behavior Checklist (ABC) were used to evaluate behavior problems at the age of 36 months. Read More

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Primary care provider perceptions and experiences of implementing hepatitis C virus birth cohort testing: a qualitative formative evaluation.

BMC Health Serv Res 2019 Apr 23;19(1):236. Epub 2019 Apr 23.

Center for Healthcare Organization and Implementation Research, VA Boston Healthcare System, Boston, MA, USA.

Background: In 2014, the Department of Veterans Affairs (VA) adopted a screening test policy for hepatitis C virus (HCV) in all "Baby Boomers" - those born between 1945 and 1965. About 1 in 12 Veterans were estimated to be infected with HCV yet approximately 34% of the birth cohort remained untested. Early HCV diagnosis and successful antiviral treatment decrease the risk of onward transmission, cirrhosis, hepatocellular carcinoma, liver transplant, and death. Read More

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http://dx.doi.org/10.1186/s12913-019-4043-zDOI Listing

Anthropometric measurements can identify small for gestational age newborns: a cohort study in rural Tanzania.

BMC Pediatr 2019 Apr 23;19(1):120. Epub 2019 Apr 23.

Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3B, Building 07-11-56, 2200, Copenhagen, Denmark.

Background: Small-for-gestational-age (SGA) is associated with increased neonatal mortality and morbidity. In low and middle income countries an accurate gestational age is often not known, making the identification of SGA newborns difficult. Measuring foot length, chest circumference and mid upper arm circumference (MUAC) of the newborn have previously been shown to be reasonable methods for detecting low birth weight (< 2500 g) and prematurity (gestational age <  37 weeks). Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1500-0DOI Listing
April 2019
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Local people's views on the evidence-based skilled-maternal-care in Mfuwe, Zambia: a qualitative study.

Authors:
Choolwe Muzyamba

BMC Pregnancy Childbirth 2019 Apr 24;19(1):135. Epub 2019 Apr 24.

UNU MERIT, Boschstraat, 246211 AX, Maastricht, The Netherlands.

Background: There is growing demand for high quality evidence-based practice in the fight against negative maternal health outcomes in Sub-Saharan Africa (SSA). Zambia is one of the countries that has transposed this evidence-based approach by outlawing Traditional Birth Attendants (TBAs) and recommending exclusive skilled-care. There is division among scholars regarding the usefulness of this approach to maternal health in SSA in general. Read More

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http://dx.doi.org/10.1186/s12884-019-2282-yDOI Listing

The role of children and their socioeconomic resources for the risk of hospitalisation and mortality - a nationwide register-based study of the total Swedish population over the age 70.

BMC Geriatr 2019 Apr 23;19(1):114. Epub 2019 Apr 23.

Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, SE-171 77, Stockholm, Sweden.

Background: Previous studies have shown that mortality in old age is associated with both number of children and their socioeconomic resources. The underlying mechanisms are unclear, as well as when during the process of health deterioration the advantage of parents over non-parents arises. This study aims to examine how the number of children and their socioeconomic resources are associated with different health outcomes among their parents, namely the hazard for i) first hospitalisation, ii) re-admission, iii) mortality after first hospitalisation, and iv) overall mortality. Read More

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http://dx.doi.org/10.1186/s12877-019-1134-yDOI Listing

Disentangling the roles of maternal and paternal age on birth prevalence of down syndrome and other chromosomal disorders using a Bayesian modeling approach.

Authors:
James A Thompson

BMC Med Res Methodol 2019 Apr 23;19(1):82. Epub 2019 Apr 23.

College of Veterinary Medicine and Biomedical Science, Texas A&M University, College Station, TX, 77843-4475, USA.

Background: Multiple neonatal and pediatric disorders have been linked to older paternal ages. Combining these findings with the evidence that many men are having children at much later ages generates considerable public health concern. The risk of paternal age has been difficult to estimate and interpret because children often have parents whose ages are similar and likely to be confounded. Read More

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http://dx.doi.org/10.1186/s12874-019-0720-1DOI Listing

Poor Bifidobacterial Colonization Is Associated with Late Provision of Colostrum and Improved with Probiotic Supplementation in Low Birth Weight Infants.

Nutrients 2019 Apr 13;11(4). Epub 2019 Apr 13.

Department of Community Perinatal Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.

This study aimed to evaluate the association between bifidobacterial colonization in low birth weight infants and perinatal factors, including the timing of initial colostrum and the effect of probiotics on this colonization. In this non-randomized controlled trial, we enrolled 98 low-birth-weight infants from a neonatal intensive care unit (NICU) in Japan. Infants were divided into three groups: group N (no intervention), group H (received non-live bifidobacteria), and group L (received live bifidobacteria). Read More

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http://dx.doi.org/10.3390/nu11040839DOI Listing

The Role of p.Ser1105Ser (in Gene) and p.Arg548Leu (in Gene) with Disease Status of Vietnamese Patients with Congenital Nephrotic Syndrome: Benign or Pathogenic?

Medicina (Kaunas) 2019 Apr 12;55(4). Epub 2019 Apr 12.

L'Hôpital Français de Hanoi, Ministry of Health, 1, Phuong Mai str., Dongda, Hanoi 100000, Vietnam.

: Congenital nephrotic syndrome (CNS), a genetic disease caused by mutations in genes on autosomes, usually occurs in the first three months after birth. A number of genetic mutations in genes, which encode for the components of the glomerular filtration barrier have been identified. We investigated mutations in , , , and genes that relate to the disease in Vietnamese patients. Read More

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http://dx.doi.org/10.3390/medicina55040102DOI Listing

Surface Body Temperature of Full-Term Healthy Newborns Immediately after Birth-Pilot Study.

Int J Environ Res Public Health 2019 Apr 12;16(8). Epub 2019 Apr 12.

Department of Functional Anatomy and Biometry, Faculty of Physical Education and Health Promotion, University of Szczecin, al. Piastów 40b/6, 71-065 Szczecin, Poland.

The aim of the study was to perform an evaluation of chosen body surface temperatures in neonates immediately after birth, and to seek a relationship between those temperatures and the factors related both to the mother and newborn. The study included 74 healthy newborns. Maternal age, body weight, body mass index before pregnancy and on delivery day, birth and pregnancy order, newborn sex, birth weight, body length, pregnancy week on delivery, as well as newborn gasometric test results were collected. Read More

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http://dx.doi.org/10.3390/ijerph16081312DOI Listing

UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells.

Int J Mol Sci 2019 Apr 22;20(8). Epub 2019 Apr 22.

Laboratory of Hygienic Sciences, Kobe Pharmaceutical University, Kobe 658-8558, Japan.

UbiA prenyltransferase domain-containing protein 1 (UBIAD1) is a vitamin K biosynthetic enzyme. We previously showed the lethality of this enzyme in UBIAD1 knockout mice during the embryonic stage. However, the biological effects of UBIAD1 deficiency after birth remain unclear. Read More

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http://dx.doi.org/10.3390/ijms20081971DOI Listing

Neonatal Resuscitation with an Intact Cord: Current and Ongoing Trials.

Authors:
Anup C Katheria

Children (Basel) 2019 Apr 22;6(4). Epub 2019 Apr 22.

Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA 92123, USA.

Premature and full-term infants are at high risk of morbidities such as intraventricular hemorrhage or hypoxic-ischemic encephalopathy. The sickest infants at birth are the most likely to die and or develop intraventricular hemorrhage. Delayed cord clamping has been shown to reduce these morbidities, but is currently not provided to those infants that need immediate resuscitation. Read More

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http://dx.doi.org/10.3390/children6040060DOI Listing

Residential exposure to radon and DNA methylation across the lifecourse: an exploratory study in the ALSPAC birth cohort.

Wellcome Open Res 2019 15;4. Epub 2019 Apr 15.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Radon (and its decay products) is a known human carcinogen and the leading cause of lung cancer in never-smokers and the second in ever-smokers. The carcinogenic mechanism from radiation is a combination of genetic and epigenetic processes, but compared to the genetic mechanisms, epigenetic processes remain understudied in humans. This study aimed to explore associations between residential radon exposure and DNA methylation in the general population. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.14991.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426102.2PMC
April 2019
1 Read

Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth.

Fetal Diagn Ther 2019 Apr 23:1-10. Epub 2019 Apr 23.

Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia,

Objective: The aim of this study was to investigate the potential utility of serum HtrA1 and HtrA3, serine proteases that are highly expressed in the developing placenta, at 15 and 20 weeks of gestation for predicting later development of adverse pregnancy outcomes of preeclampsia (PE), gestational hypertension (GHT), preterm birth (PTB), and small for gestational age (SGA) birth.

Methods: This is a nested case control study of 665 samples (330 controls, 335 cases) from the Adelaide SCOPE cohort. The cases included were 92 PE, 71 GHT, 56 PTB, and 116 SGA. Read More

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http://dx.doi.org/10.1159/000497144DOI Listing

Anticholinergic Burden and Dry Mouth in Middle-Aged People.

JDR Clin Trans Res 2019 Apr 23:2380084419844511. Epub 2019 Apr 23.

1 Periodontology and Geriatric Dentistry, Unit of Oral Health Sciences Research, University of Oulu, Oulu, Finland.

Introduction: Anticholinergic burden refers to the cumulative effect of taking 1 or more drugs with anticholinergic properties. At the moment, little is known about the association between the anticholinergic burden and dry mouth.

Objectives: The objective of this article was to study, whether an anticholinergic burden is associated with dry mouth among middle-aged people. Read More

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http://dx.doi.org/10.1177/2380084419844511DOI Listing