364,150 results match your criteria Birth: Issues in Perinatal Care [Journal]


Effect of Fentanyl Boluses on Cerebral Oxygenation and Hemodynamics in Preterm Infants: A Prospective Observational Study.

Neonatology 2020 Jul 8:1-8. Epub 2020 Jul 8.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Dalhousie University and IWK Health Center, Halifax, Nova Scotia, Canada.

Background: Fentanyl is a commonly used off-label medication for pain control and sedation in preterm infants. Yet, the effect of fentanyl on cerebral hemodynamics in preterm neonates remains unexplored.

Objective: To evaluate the effect of a bolus dose of fentanyl on the regional cerebral oxygen saturation (RcSO2), cerebral fractional tissue oxygen extraction (cFTOE) and left ventricular output (LVO) as compared with pre-administration baseline in preterm infants. Read More

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http://dx.doi.org/10.1159/000508555DOI Listing

Associations of prenatal heavy metals exposure with placental characteristics and birth weight in Hangzhou Birth Cohort: Multi-pollutant models based on elastic net regression.

Sci Total Environ 2020 Jun 30;742:140613. Epub 2020 Jun 30.

Department of Public Health, and Department of Reproductive Endocrinology of Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China; Bioelectromagnetics Laboratory, Institute of Environmental Health, Zhejiang University School of Public Health, Hangzhou, China. Electronic address:

Background: The human placenta is vulnerable to environmental pollutants, but the associations between exposure to multiple, correlated metals and placental characteristics have not been studied.

Methods: The current study population was derived from the Hangzhou Birth Cohort Study. Whole blood and urine samples were collected from mothers during 20-28 gestational week. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140613DOI Listing

Misoprostol attenuates neonatal cardiomyocyte proliferation through Bnip3, perinuclear calcium signaling, and inhibition of glycolysis.

J Mol Cell Cardiol 2020 Jul 5. Epub 2020 Jul 5.

Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Canada; Department of College Nursing in the Rady Faculty of Health Science, University of Manitoba, Winnipeg, Canada; The Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Theme, University of Manitoba, Winnipeg, Canada. Electronic address:

Systemic hypoxia resulting from preterm birth, altered lung development, and cyanotic congenital heart disease is known to impede the regulatory and developmental pathways in the neonatal heart. While the molecular mechanisms are still unknown, hypoxia induces aberrant cardiomyocyte proliferation, which may be initially adaptive, but can ultimately program the heart to fail in early life. Recent evidence suggests that the prostaglandin E1 analogue, misoprostol, is cytoprotective in the hypoxia-exposed neonatal heart by impacting alternative splicing of the Bcl-2 family member Bnip3, resulting in the generation of a variant lacking the third exon (Bnip3ΔExon3 or small Nip; sNip). Read More

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http://dx.doi.org/10.1016/j.yjmcc.2020.06.010DOI Listing

Associations of Birth Weight for Gestational Age with Child Health and Neurodevelopment among Term Infants: A Nationwide Japanese Population-Based Study.

J Pediatr 2020 Jul 5. Epub 2020 Jul 5.

Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Objective: To examine the association of specific Z-score categories of birth weight for gestational age (GA) with child health and neurodevelopment using a large nationwide survey in Japan, focusing on term infants.

Study Design: We included 36,321 children born in 2010. Hospitalization up to 66 months of age was used as an indicator of health status, and responses to questions about age-appropriate behaviors at 30 and 66 months of age were used to indicate neurobehavioral development. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.075DOI Listing

Regulatory T Cells Play a Role in a Subset of Idiopathic Preterm Labor/Birth and Adverse Neonatal Outcomes.

Cell Rep 2020 Jul;32(1):107874

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI 48201, USA; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA; Department of Computer Science, Wayne State University College of Engineering, Detroit, MI 48201, USA.

Regulatory T cells (Tregs) have been exhaustively investigated during early pregnancy; however, their role later in gestation is poorly understood. Herein, we report that functional Tregs are reduced at the maternal-fetal interface in a subset of women with idiopathic preterm labor/birth, which is accompanied by a concomitant increase in Tc17 cells. In mice, depletion of functional Tregs during late gestation induces preterm birth and adverse neonatal outcomes, which are rescued by the adoptive transfer of such cells. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107874DOI Listing

Birth Month and Influenza Vaccination in Children.

N Engl J Med 2020 07;383(2):184-185

Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1056/NEJMc2005928DOI Listing

House dust endotoxin, asthma and allergic sensitization through childhood into adolescence.

Clin Exp Allergy 2020 Jul 8. Epub 2020 Jul 8.

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.

Background: House dust endotoxin may have beneficial effects on allergic sensitization and asthma in children. Evidence is scarce for adolescents and most studies so far have been cross-sectional and limited to a single exposure measurement.

Objective: We assessed associations of house dust endotoxin with asthma and allergic sensitization from birth to age 17 years longitudinally taking into account exposure early in life and at primary school age. Read More

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http://dx.doi.org/10.1111/cea.13705DOI Listing

Perinatal and perioperative factors associated with mortality and an increased need for hospital care in infants with transposition of the great arteries: a nationwide 11-year population-based cohort.

Acta Obstet Gynecol Scand 2020 Jul 8. Epub 2020 Jul 8.

Department of Pediatric Cardiology, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Introduction: Newborns with transposition of the great arteries (d-TGA) need immediate care for an optimal outcome. This study comprised a nationwide 11-year population-based cohort of d-TGA infants, and assessed whether the implementation of a nationwide systematic fetal screening program, or other perinatal - or perioperative factors, are associated with mortality or an increased need for hospital care.

Material And Methods: The national cohort consisted of all live-born infants with simple d-TGA (TGA +/- small ventricular septal defect, n = 127) born in Finland during 2004-2014. Read More

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http://dx.doi.org/10.1111/aogs.13953DOI Listing

Growing up in Ancient Sardinia: Infant-toddler dietary changes revealed by the novel use of hydrogen isotopes (δ2H).

PLoS One 2020 8;15(7):e0235080. Epub 2020 Jul 8.

Department of Human Evolutionary Biology, Harvard University, Boston, Massachusetts, Unitied States of America.

Detailed information about the lives and deaths of children in antiquity is often in short supply. Childhood dietary histories are, however, recorded and maintained in the teeth of both juveniles and adults. Primary tooth dentinal collagen does not turn over, preserving a sequential record of dietary changes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235080PLOS

A National Measurement Framework to Assess and Improve Sickle Cell Care in 4 US Regions.

Public Health Rep 2020 Jul 8:33354920935068. Epub 2020 Jul 8.

50980 National Institute for Children's Health Quality, Boston, MA, USA.

Objectives: Coordinated measurement strategies are needed to inform collaborative approaches to improve access to and quality of care for persons with sickle cell disease (SCD). The objective of our study was to develop a multilevel measurement strategy to assess improvements in access to and quality of care for persons with SCD in 4 US regions.

Methods: From 2014 through 2017, regional grantees in the Sickle Cell Disease Treatment Demonstration Program collected administrative and patient-level electronic health record (EHR) data to assess quality improvement initiatives. Read More

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http://dx.doi.org/10.1177/0033354920935068DOI Listing

Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry.

Hypertension 2020 08 8;76(2):545-553. Epub 2020 Jul 8.

Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium (M.P., S.D.M., A. Pasquet, A. Persu).

Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15349DOI Listing

The Clustering of Adverse Childhood Experiences in the Avon Longitudinal Study of Parents and Children: Are Gender and Poverty Important?

J Interpers Violence 2020 Jul 8:886260520935096. Epub 2020 Jul 8.

University College London, UK.

Previous research has demonstrated a graded relationship between the number of Adverse Childhood Experiences reported (an ACE score) and child outcomes. However, ACE scores lack specificity and ignore the patterning of adversities, which are informative for interventions. The aim of the present study was to explore the clustering of ACEs and whether this clustering differs by gender or is predicted by poverty. Read More

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http://dx.doi.org/10.1177/0886260520935096DOI Listing

The Age-Specific Cervical Cancer Incidence Differs Between Human Papillomavirus Types: Implications for Predicting the Impact of Elimination Programs.

Am J Epidemiol 2020 Jul 8. Epub 2020 Jul 8.

Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden.

The elimination of cervical cancer rests on high efficacy of Human Papillomavirus (HPV) vaccines. The HPV type distribution among Invasive Cervical Cancer (ICC) is used to make predictions about the impact of eliminating different HPV types, but accumulating evidence of differences in age-specific cancer incidence by HPV type exists. We used one of the largest population-based series of HPV genotyping of ICCs (n = 2,850; Sweden, 2002-2011) to estimate the age-specific ICC incidence by HPV type and provide estimates of the cancer-protective impact of the removal of different HPV types. Read More

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http://dx.doi.org/10.1093/aje/kwaa121DOI Listing

Rapid Increase in Clearance of Phenobarbital in Neonates on Extracorporeal Membrane Oxygenation: A Pilot Retrospective Population Pharmacokinetic Analysis.

Pediatr Crit Care Med 2020 Jun 26. Epub 2020 Jun 26.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

Objectives: This study characterizes the changes in the pharmacokinetics of phenobarbital associated with extracorporeal membrane oxygenation treatment in neonates, to illustrate our findings and provide guidance on dosing.

Design: Retrospective pilot population pharmacokinetic analysis.

Setting: Neonatal ICU. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002402DOI Listing

Validation of assisted reproductive technology in the Medical Birth Registry of Norway versus the Norwegian Prescription Database.

Epidemiology 2020 Jun 24. Epub 2020 Jun 24.

Background: Increasing attention has been given the long-term effects of assisted reproductive technology (ART). This study assessed the validity and completeness of ART as registered in the Medical Birth Registry of Norway (MBRN) using drug prescription data from the Norwegian Prescription Database (NorPD) as reference.

Methods: In this nationwide registry validation study, we included all pregnancies recorded in the MBRN between 2005 and 2017. Read More

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http://dx.doi.org/10.1097/EDE.0000000000001228DOI Listing

Positive pressure ventilation in the weaning of preterm newborns.

Minerva Pediatr 2020 Jul 7. Epub 2020 Jul 7.

Health Institute Elpídio de Almeida, Paraíba, Brazil.

Background: Weaning from invasive mechanical ventilation (IMV) of preterm newborns (PTNB) is one of the critical stages of life support in the neonatal intensive care unit (NICU). Noninvasive positive pressure ventilation (NPPV) has been used to facilitate weaning from IMV and includes continuous positive airway pressure (CPAP) without or with inspiratory pressure support (Bilevel NPPV). Nevertheless, there is little information about their adherence and success rate during weaning process. Read More

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http://dx.doi.org/10.23736/S0026-4946.20.05677-7DOI Listing

Agnathia otocephaly: A case from the Katanga Copperbelt.

Birth Defects Res 2020 Jul 8. Epub 2020 Jul 8.

Center for Human Genetics, University Hospital, KU Leuven, Leuven, Belgium.

Background: Agnathia otocephaly is a rare craniofacial malformation complex characterised by absent/hypoplastic mandible, abnormally positioned ears meeting at level of neck. Besides mutations in two genes, PRRX1 and OTX2, a teratogenic cause has been suggested. A higher risk of congenital malformations has been associated with paternal work in mining in the Democratic Republic of the Congo's part of the Copperbelt. Read More

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http://dx.doi.org/10.1002/bdr2.1758DOI Listing

Head midline position for preventing the occurrence or extension of germinal matrix-intraventricular haemorrhage in preterm infants.

Cochrane Database Syst Rev 2020 Jul 7;7:CD012362. Epub 2020 Jul 7.

Department of Clinical Sciences Lund, Paediatrics, Lund University, Skåne University Hospital, Lund, Sweden.

Background: Head position during care may affect cerebral haemodynamics and contribute to the development of germinal matrix-intraventricular haemorrhage (GM-IVH) in very preterm infants. Turning the head toward one side may occlude jugular venous drainage while increasing intracranial pressure and cerebral blood volume. It is suggested that cerebral venous pressure is reduced and hydrostatic brain drainage improved if the infant is cared for in the supine 'head midline' position. Read More

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http://dx.doi.org/10.1002/14651858.CD012362.pub3DOI Listing

Comparisons of pregnancy outcomes between twin pregnancies with and without second trimester amniocentesis.

Prenat Diagn 2020 Jul 8. Epub 2020 Jul 8.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objective: To assess the amniocentesis-related pregnancy loss rate and preterm birth rate among twin pregnancies undergoing amniocentesis METHODS: A retrospective cohort study was conducted at a tertiary center. The study group included twin pregnancies undergoing amniocentesis during 16-22 weeks of gestation. The control group was those not undergoing amniocentesis. Read More

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http://dx.doi.org/10.1002/pd.5783DOI Listing

Evaluation of the fibulin 5 gene polymorphism as a factor related to the occurrence of pelvic organ prolapse.

Rev Assoc Med Bras (1992) 2020 May 3;66(5):680-686. Epub 2020 Jul 3.

Departamento de Ginecologia e Obstetrícia, Faculdade de medicina do ABC, Santo André, SP, Brasil.

OBJECTIVE Pelvic organ prolapse (POP) is a very frequent situation in our population that may lead to a significant decrease in patients' quality of life. Currently, we are looking for predictive factors for the development of POPs; thus, this study seeks to evaluate whether the Fibulin 5 polymorphism (FBLN5) is associated with the occurrence of POP. METHODS This is a cohort study with postmenopausal women who were divided into groups by POP stage: POP stages 0 and I (control group) and POP stages III and IV (case group). Read More

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http://dx.doi.org/10.1590/1806-9282.66.5.680DOI Listing

INCIDENCE OF SMALL FOR GESTATIONAL AGE NEONATES, ACCORDING TO THE FENTON AND INTERGROWTH-21ST CURVES IN A LEVEL II MATERNITY.

Rev Paul Pediatr 2021 3;39:e2019245. Epub 2020 Jul 3.

Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Objective: To compare the incidence of small for gestational age infants among late preterm and term newborns, using the Fenton and Intergrowth-21st curves.

Methods: Observational and retrospective study with newborns in a level II maternity. The study was approved by the Institution's Ethics Committee. Read More

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http://dx.doi.org/10.1590/1984-0462/2021/39/2019245DOI Listing

[Expenditures on childbirth care: a comparison of the 2004 and 2015 birth cohorts in Pelotas, Rio Grande do Sul State, Brazil].

Cad Saude Publica 2020 3;36(7):e00120019. Epub 2020 Jul 3.

Programa de Pós-graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, Brazil.

Although most childbirth care in Brazil is financed by the Brazilian Unified National Health System (SUS), there are out-of-pocket expenditures (private personal costs) involved in births. This study aims to compare maternal out-of-pocket expenditures in births of children from the Pelotas Birth Cohorts of 2004 and 2015. The study drew on information collected right after birth and at three months of age. Read More

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http://dx.doi.org/10.1590/0102-311x00120019DOI Listing

Microbiome of the first stool and overweight at age 3 years: A prospective cohort study.

Pediatr Obes 2020 Jul 7:e12680. Epub 2020 Jul 7.

PEDEGO Research Unit, Medical Research Center, University of Oulu, Oulu, Finland.

Background: Several reports have revealed that the first-pass meconium hosts a diverse microbiome, but its clinical significance is not known.

Objective: We designed a prospective population-based cohort study to evaluate whether the meconium microbiome predicts subsequent growth in children.

Methods: The study comprised 212 consecutive newborns with a meconium sample and a follow-up sample at 1 year of age. Read More

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http://dx.doi.org/10.1111/ijpo.12680DOI Listing

Associations of Breastfeeding, Maternal Smoking, and Birth Weight With Bone Density and Microarchitecture in Young Adulthood: a 25-Year Birth-Cohort Study.

J Bone Miner Res 2020 Jul 8. Epub 2020 Jul 8.

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.

We have found that early-life exposures are associated with areal bone mineral density (aBMD) at ages 8 and 16 years. This study aimed to assess whether these associations persist into young adulthood when peak bone mass (PBM) is achieved and extend this analysis to microarchitecture. Participants were followed from perinatal period to 25 years old (n = 201). Read More

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http://dx.doi.org/10.1002/jbmr.4044DOI Listing

Cash-based maternal health interventions can improve childhood vaccination-Evidence from India.

Health Econ 2020 Jul 7. Epub 2020 Jul 7.

Department of Economics, The Graduate Center, City University of New York, New York, New York, USA.

Childhood vaccination has lagged in countries like India, despite its demonstrated positive effects on health outcomes like infant mortality. At the same time, many conditional cash transfer programs have been effective in improving health outcomes. We estimate the effect of the world's largest maternal health program, Janani Suraksha Yojana (JSY, maternal protection scheme), on childhood vaccination in India. Read More

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http://dx.doi.org/10.1002/hec.4129DOI Listing

Limited agreement between clinical assessment of infant colour at birth and oxygen saturation in a hospital in Ethiopia.

Acta Paediatr 2020 Jul 7. Epub 2020 Jul 7.

Department of Woman's and Child's Health, University of Padua, Padua, Italy.

Aim: To evaluate the relationship between clinical assessment of infant colour and oxygen saturation at birth in a low-resource setting.

Methods: Classification of infant colour (cyanotic, pink or unclear) by midwives was compared to pulse-oximeter data at 60-90-120-300 seconds after birth in 60 neonates.

Results: Overall, oxygen saturation increased over time (p<0. Read More

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http://dx.doi.org/10.1111/apa.15463DOI Listing

High expression levels of pyrimidine metabolic rate-limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus datasets.

Purinergic Signal 2020 Jul 8. Epub 2020 Jul 8.

Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect, Fujian Maternity and Child Health Hospital,, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Reprogramming of metabolism is described in many types of cancer and is associated with the clinical outcomes. However, the prognostic significance of pyrimidine metabolism signaling pathway in lung adenocarcinoma (LUAD) is unclear. Using the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets, we found that the pyrimidine metabolism signaling pathway was significantly enriched in LUAD. Read More

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http://dx.doi.org/10.1007/s11302-020-09711-4DOI Listing

Impacts of a Home Visiting Program Enhanced with Content on Healthy Birth Spacing.

Matern Child Health J 2020 Jul 7. Epub 2020 Jul 7.

Mathematica, P.O. Box 2393, Princeton, NJ, 08543, USA.

Objectives: This study sought to determine the impact of Healthy Families Healthy Futures (HFHF) enhanced with Steps to Success (STS). HFHF is a structured home visiting program for teen parents in Houston that focuses on improving parenting skills and preventing child abuse. HFHF enhanced with STS includes content and activities aimed to reduce repeat pregnancies within 24 months after the first child's birth. Read More

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http://dx.doi.org/10.1007/s10995-020-02968-6DOI Listing

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals.

Arch Toxicol 2020 Jul 7. Epub 2020 Jul 7.

Division of Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.

Modern living challenges female reproductive health. We are witnessing a rise in reproductive disorders and drop in birth rates across the world. The reasons for these manifestations are multifaceted and most likely include continuous exposure to an ever-increasing number of chemicals. Read More

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http://dx.doi.org/10.1007/s00204-020-02834-yDOI Listing

Blood mitochondrial DNA levels remain elevated from birth to early life in children HIV-exposed uninfected exposed to combination antiretroviral therapy in utero.

J Infect Dis 2020 Jul 8. Epub 2020 Jul 8.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Background: Combination antiretroviral therapy (cART) during pregnancy prevents vertical transmission, but many antiretrovirals cross the placenta and several can affect mitochondria. Exposure to maternal HIV and/or cART could have long-term effects on children HIV-exposed uninfected (CHEU). Our objective was to compare blood mitochondrial DNA (mtDNA) content in CHEU and children HIV-unexposed uninfected (CHUU), at birth and in early life. Read More

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http://dx.doi.org/10.1093/infdis/jiaa410DOI Listing

Cohort Profile Update: The Isle of Wight Whole Population Birth Cohort (IOWBC).

Int J Epidemiol 2020 Jul 8. Epub 2020 Jul 8.

Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.

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http://dx.doi.org/10.1093/ije/dyaa068DOI Listing

Risk factors for women's non-utilization of decentralized primary health care facilities for postnatal care in rural western Ethiopia.

Ther Adv Reprod Health 2020 Jan-Dec;14:2633494120928340. Epub 2020 Jun 26.

Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, USA.

Objective: Evidence suggests postnatal care contributes to reductions in maternal mortality. In Ethiopia, the proportion of women who do not utilize postnatal care after birth is high and the frequency of postnatal checks falls short of the four visits recommended by World Health Organization. This study examined risk factors associated with non-utilization of decentralized local health facilities, namely, health posts, health centers, and a primary hospital, for postnatal care services in Gida Ayana in rural western Ethiopia. Read More

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http://dx.doi.org/10.1177/2633494120928340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323273PMC

Improving the coverage and accuracy of syphilis testing: The development of a novel rapid, point-of-care test for confirmatory testing of active syphilis infection and its early evaluation in China and South Africa.

EClinicalMedicine 2020 Jul 27;24:100440. Epub 2020 Jun 27.

Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia.

Background: Current point-of-care tests (POCT) for syphilis, based on the detection of (TP) total antibodies, have limited capacity in distinguishing between active and past/treated syphilis. We report the development and early evaluation of a new prototype POCT based on the detection of TP-IgA antibodies, a novel biomarker for active syphilis.

Methods: The TP-IgA POCT (index test) was developed in response to the World Health Organisation (WHO) target product profile (TPP) for a POCT for confirmatory syphilis testing. Read More

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http://dx.doi.org/10.1016/j.eclinm.2020.100440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327895PMC

First-year drug therapy of new-onset rheumatoid and undifferentiated arthritis: a nationwide register-based study.

BMC Rheumatol 2020 3;4:34. Epub 2020 Jul 3.

Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland.

Background: In this retrospective cohort study, we evaluated the drug therapies used for early rheumatoid (RA) and undifferentiated (UA) arthritis patients.

Methods: From a nationwide register maintained by the Social Insurance Institution, information on sex, date of birth, and date of special medicine reimbursement decision for all new Finnish RA and UA patients between 2011 and 14 were collected, and their DMARD (Disease Modifying Antirheumatic Drug) purchases during the first year after the diagnosis were analyzed.

Results: A total of 7338 patients with early RA (67. Read More

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http://dx.doi.org/10.1186/s41927-020-00127-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333434PMC

Maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes: A cross-sectional study.

Int J Reprod Biomed (Yazd) 2020 May 31;18(5):339-346. Epub 2020 May 31.

Shahid Sadougui Hospital, Shahid Sadougui University of Medical Sciences, and Health Services, Yazd, Iran.

Background: Pregnancy is a process associated with various metabolic and hormonal changes, and polycystic ovary syndrome (PCOS) can affect this process.

Objective: This study aimed to evaluate and compare the maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes.

Materials And Methods: In this cross-sectional study, 200 pregnant women with PCOS according to the 2003 ESHRE/ASRM criteria were categorized into four phenotype groups (A-D). Read More

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http://dx.doi.org/10.18502/ijrm.v13i5.7154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306059PMC

The fetal/placental weight ratio is associated with the incidence of atopic dermatitis in female infants during the first 14 months: The Hamamatsu Birth Cohort for Mothers and Children (HBC Study).

Int J Womens Dermatol 2020 Jun 5;6(3):176-181. Epub 2020 Mar 5.

Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Background: Among atopic diseases, atopic dermatitis is the most common allergic disease in children and influences both infantile and parental quality of life.

Objective: The present study investigated the sex-specific relationship between the fetal/placental weight ratio and The incidence of atopic dermatitis in infants during the first 14 months of life.

Methods: Study participants were 922 infants (462 female and 460 male) from singleton pregnancies enrolled in the Hamamatsu Birth Cohort for Mothers and Children (HBC Study) after the exclusion of 298 with missing data on atopic dermatitis. Read More

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http://dx.doi.org/10.1016/j.ijwd.2020.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330435PMC

Predicting Lung Health Trajectories for Survivors of Preterm Birth.

Front Pediatr 2020 19;8:318. Epub 2020 Jun 19.

Telethon Kids Institute, Perth, WA, Australia.

Rates of preterm birth (<37 weeks of gestation) are increasing worldwide. Improved perinatal care has markedly increased survival of very (<32 weeks gestation) and extremely (<28 weeks gestation) preterm infants, however, long term respiratory sequalae are common among survivors. Importantly, individual's lung function trajectories are determined early in life and tend to track over the life course. Read More

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http://dx.doi.org/10.3389/fped.2020.00318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316963PMC

First-Time Mothers' Enjoyment of Breastfeeding Correlates with Duration of Breastfeeding, Sense of Coherence, and Parental Couple and Child Relation: A Longitudinal Swedish Cohort Study.

Nurs Res Pract 2020 19;2020:8194389. Epub 2020 Jun 19.

School of Health Sciences, University of Skövde, Post Box 408, S 541 28, Skövde, Sweden.

Objectives: Many women do not reach their own breastfeeding goals regarding duration of breastfeeding. Different factors influence breastfeeding, and to learn more about breastfeeding within a multidimensional and longitudinal perspective, further research is needed. Therefore, the aim of the present study was to investigate diverse factors correlated with first-time mothers' enjoyment of breastfeeding and breastfeeding duration, between childbirth and two years after birth. Read More

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http://dx.doi.org/10.1155/2020/8194389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321520PMC

Hepatitis B virus infection and associated factors among pregnant women attending antenatal clinics in West Hararghe public hospitals, Oromia region, Ethiopia.

Pan Afr Med J 2020 18;35:128. Epub 2020 Apr 18.

College of Health and Medical Science, Haramaya University, Harar, Ethiopia.

Introduction: Globally, approximately 350-400 million persons are chronically infected with hepatitis B virus (HBV), over 65 million of whom are in Africa. One in four people with chronic hepatitis B develop serious health problems. Mother-to-child transmission (MTCT) is responsible for more than half of chronic infections. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.128.17645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320783PMC

Relationship between serum insulin and point-of-admission blood glucose of ill neonates at a tertiary health facility in Nigeria.

Pan Afr Med J 2020 8;35:106. Epub 2020 Apr 8.

Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria.

Introduction: Optimal glucose metabolism is important in neonatal survival especially in the first days of life. Insulin play a significant role in maintaining blood glucose homeostasis. This study set out to determine the serum insulin levels of ill neonates as related to their point-of-admission blood glucose estimation at the Wesley Guild Hospital, Ilesa, Nigeria. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.106.18929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320779PMC

Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway.

Front Immunol 2020 19;11:1123. Epub 2020 Jun 19.

Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Alternative complement pathway (AP) plays an important role in the development of sepsis, which is life threatening. Deficiency of factor H-related protein 1 (FHR-1), which is a regulator of AP, has been considered as a susceptible factor for atypical hemolytic uremic syndrome (aHUS) and other types of nephropathy when an inducer such as infection exists. However, the underlying mechanism of the disease development is largely unknown. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316958PMC

Mapping the Specific Pathways to Early-Onset Mental Health Disorders: The "Watch Me Grow for REAL" Study Protocol.

Front Psychiatry 2020 19;11:553. Epub 2020 Jun 19.

Faculty of Science, School of Psychology, University of Sydney, Sydney, NSW, Australia.

Background: From birth, the human propensity to selectively attend and respond to critical super-stimuli forms the basis of future socio-emotional development and health. In particular, the first super-stimuli to preferentially engage and elicit responses in the healthy newborn are the physical touch, voice and face/eyes of caregivers. From this grows selective attention and responsiveness to emotional expression, scaffolding the development of empathy, social cognition, and other higher human capacities. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319093PMC

Advances toward precision medicine for bipolar disorder: mechanisms & molecules.

Mol Psychiatry 2020 Jul 7. Epub 2020 Jul 7.

Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%, the effective treatment, and prevention of bipolar disorder represents an area of significant unmet medical need. While more than half a century has passed since the introduction of lithium into widespread use at the birth of modern psychopharmacology, that medication remains a mainstay for the acute treatment and prevention of recurrent mania/hypomania and depression that characterize bipolar disorder. However, the continued limited understanding of how lithium modulates affective behavior and lack of validated cellular and animal models have resulted in obstacles to discovering more effective mood stabilizers with fewer adverse side effects. Read More

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http://dx.doi.org/10.1038/s41380-020-0831-4DOI Listing

New-generation intravenous fat emulsions and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.

J Perinatol 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Background: Fat emulsion is an important component of parenteral nutrition in premature infants. However, intravenous fat emulsions (IVFE) was reported to be associated with some serious complications, such as bronchopulmonary dysplasia (BPD). Compared to conventional soybean oil-based IVFE, new-generation IVFE may protect against BPD but the results are conflicting. Read More

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http://dx.doi.org/10.1038/s41372-020-0716-zDOI Listing

Demystifying the factors associated with rural-urban gaps in severe acute malnutrition among under-five children in low- and middle-income countries: a decomposition analysis.

Sci Rep 2020 Jul 7;10(1):11172. Epub 2020 Jul 7.

Division of Health Sciences, Populations, Evidence and Technologies Group, University of Warwick, Coventry, UK.

What explains the underlying causes of rural-urban differentials in severe acute malnutrition (SAM) among under-five children is poorly exploited, operationalized, studied and understood in low- and middle-income countries (LMIC). We decomposed the rural-urban inequalities in the associated factors of SAM while controlling for individual, household, and neighbourhood factors using datasets from successive demographic and health survey conducted between 2010 and 2018 in 51 LMIC. The data consisted of 532,680 under-five children nested within 55,823 neighbourhoods across the 51 countries. Read More

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http://dx.doi.org/10.1038/s41598-020-67570-wDOI Listing

Factors associated with early opioid dispensing compared with NSAID and muscle relaxant dispensing after a work-related low back injury.

Occup Environ Med 2020 Jul 7. Epub 2020 Jul 7.

Institute for Work and Health, Toronto, Ontario, Canada.

Objectives: The objective of this historical cohort study was to determine the claimant and prescriber factors associated with receiving opioids at first postinjury dispense compared with non-steroidal anti-inflammatory drugs (NSAIDs) and skeletal muscle relaxants (SMRs) in a sample of workers' compensation claimants with low back pain (LBP) claims between 1998 and 2009 in British Columbia, Canada.

Methods: Administrative workers' compensation, prescription and healthcare data were linked. The association between claimant factors (sociodemographics, occupation, diagnosis, comorbidities, pre-injury prescriptions and healthcare) and prescriber factors (sex, birth year, specialty) with drug class(es) at first dispense (opioids vs NSAIDs/SMRs) was examined with multilevel multinomial logistic regression. Read More

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http://dx.doi.org/10.1136/oemed-2019-106380DOI Listing

Immediate parent-infant skin-to-skin study (IPISTOSS): study protocol of a randomised controlled trial on very preterm infants cared for in skin-to-skin contact immediately after birth and potential physiological, epigenetic, psychological and neurodevelopmental consequences.

BMJ Open 2020 Jul 6;10(7):e038938. Epub 2020 Jul 6.

Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.

Introduction: In Scandinavia, 6% of infants are born preterm, before 37 gestational weeks. Instead of continuing in the in-utero environment, maturation needs to occur in a neonatal unit with support of vital functions, separated from the mother's warmth, nutrition and other benefits. Preterm infants face health and neurodevelopment challenges that may also affect the family and society at large. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-038938DOI Listing