334,277 results match your criteria Birth: Issues in Perinatal Care [Journal]


Systemic Arterial Hypertension in Childhood: A Challenge Related to the Increasing Survival of Very Low Birth Weight Preterm Infants.

Am J Perinatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Objective:  To verify the prevalence of systemic arterial hypertension (SAH) and to identify possible early predictors of SAH at ages 2 and 4 years in very low birth weight (VLBW) infants.

Study Design:  This is a prospective cohort study including inborn children with birth weight (BW) <1,500 g. Arterial blood pressure measurements were performed at 2 and 4 years. Read More

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December 2018

Prenatal thallium exposure and poor growth in early childhood: A prospective birth cohort study.

Environ Int 2018 Dec 8;123:224-230. Epub 2018 Dec 8.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, People's Republic of China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, People's Republic of China. Electronic address:

Background: Thallium (Tl) exposure remains a public health problem with potential impacts on humans. Studies have suggested that prenatal exposure to thallium may be associated with fetal growth, but no studies are known have explored its association with early childhood anthropometry.

Objective: To investigate the effects of prenatal Tl exposures on early child growth and development aged 0-2 years in a prospective birth cohort study. Read More

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December 2018

Brief reaching training with "sticky mittens" in preterm infants: Randomized controlled trial.

Hum Mov Sci 2018 Dec 8;63:138-147. Epub 2018 Dec 8.

Physical Therapy Section, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil. Electronic address:

Objective: To examine whether a brief reaching training with sticky mittens was effective to improve reaching behavior in newly reaching preterm infants.

Methods: In this randomized controlled trial, twenty four 5-month-old (±16-week-old corrected age) preterm infants were randomly allocated into experimental or control groups. Infants were assessed three times in a single session: pretraining (immediately before training), posttraining (immediately after training), and retention (4 min after the posttraining). Read More

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December 2018

Impact of maternal low-level cadmium exposure on glucose and lipid metabolism of the litter at different ages after weaning.

Chemosphere 2018 Nov 26;219:109-121. Epub 2018 Nov 26.

Univ. Grenoble Alpes, Inserm U1055, LBFA, 38000 Grenoble, France. Electronic address:

Cadmium (Cd) is a metal which may participate in the development of type II diabetes even if Cd exposure levels are mild. However, experimental studies focusing on daily environmentally relevant doses are scarce, particularly for glucose metabolism of the offspring of chronically exposed mothers. The aim is to measure the impact of maternal low level Cd exposure on glucose and lipid metabolism of offspring. Read More

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November 2018

Cross-border and domestic surrogacy in the UK context: an exploration of practical and legal decision-making.

Hum Fertil (Camb) 2018 Dec 11:1-12. Epub 2018 Dec 11.

b NGA Law and Brilliant Beginnings , London , UK.

This study aimed to explore UK intending parent's reasons for cross-border and domestic surrogacy, their preparations for the birth and the practical and legal challenges faced after the birth. An online survey was completed by 203 participants, of which 132 had a child born through surrogacy, 33 were in the process of surrogacy and 38 were planning a surrogacy arrangement. The most common reason for pursuing surrogacy in the UK was wanting a relationship with the surrogate (43%; n = 17) and for conducting surrogacy in the USA was because of a better legal framework (97%; n = 60). Read More

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December 2018

Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle-aged Caucasians: the Northern Finland Birth Cohort Eye study.

Acta Ophthalmol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.

Purpose: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle-aged Caucasians.

Methods: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured in the right eye using a semi-automated computer-assisted program. Read More

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December 2018
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Review shows that thyroid hormone substitution could benefit transient hypothyroxinaemia of prematurity but treatment strategies need to be clarified.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Neonatology, University Hospitals Leuven, KU, Leuven, Belgium.

Aim: Thyroid hormones are crucial for fetal and neonatal brain development. This paper provides an overview of the normal role of thyroid hormones in fetal brain development and the pathophysiology of transient hypothyroxinaemia of prematurity (THOP). It also discusses the diagnostic and therapeutic controversies around THOP and looks at directions for future research. Read More

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December 2018

Aerodigestive and communicative behaviors in anencephalic and hydranencephalic infants.

Birth Defects Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Linguistics, University of British Columbia, Vancouver, Canada.

The aerodigestive and communicative behaviors of anencephalic and hydranencephalic patients are assessed from literature sources and are compared with documented neural structures present in the brainstem, subcortical, and cortical regions of the brain. Much of the data analyzed corroborate previous neurological studies, which focus on central pattern generators and development in model organisms. However, findings suggest that further research is necessary to determine which components of these systems support these behaviors. Read More

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December 2018

Developmental defects of enamel in the deciduous incisors of infants born preterm: prospective cohort.

Oral Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Oral Health, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Objective: Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake, and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants.

Subjects And Methods: In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Read More

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December 2018

Trends and state variations in out-of-hospital births in the United States, 2004-2017.

Birth 2018 Dec 10. Epub 2018 Dec 10.

Community Health Sciences Department, Boston University School of Public Health, Boston, Massachusetts.

Background: Out-of-hospital births have been increasing in the United States, although past studies have found wide variations between states. Our purpose was to examine trends in out-of-hospital births, the risk profile of these births, and state differences in women's access to these births.

Methods: National birth certificate data from 2004 to 2017 were analyzed. Read More

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December 2018

Incidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital.

J Obstet Gynaecol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aim: To obtain the incidence of preterm premature rupture of membranes (PPROM) at Siriraj Hospital during 2012-2016 and to identify its possible risk factors in singleton pregnancies.

Methods: This study was a retrospective case-control study. The institutional ethical committee has approved the study. Read More

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December 2018

Anaemia in pregnancy among Aboriginal and Torres Strait Islander women of Far North Queensland: A retrospective cohort study.

Nutr Diet 2018 Nov;75(5):457-467

Centre for Chronic Disease Prevention, Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, Queensland, Australia.

Aim: Anaemia during pregnancy is common worldwide. In Australia between 7.1% and 11% of mothers have been reported to have anaemia in pregnancy. Read More

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November 2018
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Iron-fortified formula use in young children and association with socioeconomic factors in the French nationwide ELFE cohort.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Inserm, UMR1153, Centre de Recherche en Épidémiologie et Statistique Sorbonne Paris Cité (CRESS), équipe Épidémiologie Périnatale, Obstétricale et Pédiatrique (ÉPOPé) Labex GR-Ex, Paris, France.

Sacri A-S, de Lauzon-Guillain B, Dufourg M-D, Bois C, Charles M A, Chalumeau M. Iron-fortified formula use in young children and association with socioeconomic factors in the French nationwide ELFE cohort.

Aim: To study the rate of iron-fortified infant formula (IFF) use in young children in France and its association with socioeconomic factors. Read More

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December 2018

Model that predicted death or disabilities in premature infants was valid at seven years of age.

Acta Paediatr 2018 Dec 8. Epub 2018 Dec 8.

Neonatologist. 12 de Octubre University Hospital, Madrid, Spain.

Aim: Validated a model that used bronchopulmonary dysplasia (BPD), brain injuries measured using ultrasound and retinopathy of prematurity (ROP) to predict late death or disability in premature infants at seven years of age.

Methods: A retrospective study was performed at the 12 de Octubre Hospital neonatal unit in Madrid. A logistic model was applied to estimate the independent prognostic contribution of each morbidity and the effect that the combination of morbidities had on the seven-year outcomes. Read More

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December 2018

Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: waning and association with self-reported severity and duration of illness.

Influenza Other Respir Viruses 2018 Dec 9. Epub 2018 Dec 9.

Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, 0213, Oslo, Norway.

Background: A population-based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy.

Objectives: We studied maternal A(H1N1)pdm09-specific hemagglutination inhibition (HI)-titer levels and waning in women with influenza-like illness (ILI) in pregnancy compared to vaccinated women. Moreover, we studied the association between HI-titers and self-reported severity and duration of ILI. Read More

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December 2018

We need to treat pregnant women as adults: Women should be consented for an attempt at normal vaginal birth as for operative delivery, with risks and potential complications explained.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):701-703

Sydney Law School, University of Sydney, Sydney, New South Wales, Australia.

Since the mid-90s, Australian law has required doctors to disclose material risks of proposed treatment. Medical practitioners have had two decades to adapt, and, by and large, patient autonomy is acknowledged and respected by obtaining 'informed consent'. While problems with obtaining consent do surface in medico-legal litigation, practitioners are generally aware of the need to do so and usually comply with requirements. Read More

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December 2018

Vaginal delivery: An argument against requiring consent.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):704-706

ANU Medical School, ANU College of Health and Medicine, Canberra, Australian Capital Territory, Australia.

Birth by vaginal delivery is an evolutionary process refined over millennia to create a sustainable and safe method of human reproduction. A key argument against requiring consent for vaginal birth acknowledges that from an evolutionary point of view, vaginal delivery has successfully accompanied human development and remains the natural and default form of human birth. Concern has been raised by the Montgomery court case in the United Kingdom; however, the ruling does not mean consent is required for normal birth. Read More

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December 2018

A de novo 1p35.2 microdeletion including PUM1 identified in a patient with sporadic West syndrome.

Congenit Anom (Kyoto) 2018 Dec 10. Epub 2018 Dec 10.

Institute of Medical Genetics, Tokyo Women's Medical University, Tokyo, Japan.

Microdeletions in 1p35.2 region are rare and there are only two reports . Here, we report an additional patient with a de novo 1p35. Read More

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December 2018

[Is it Reasonable to Establish an Independently Managed Obstetric Unit in a Small Hospital and Does it Result in Measurable Changes in Quality of Maternity Care?]

Z Geburtshilfe Neonatol 2018 Dec 7. Epub 2018 Dec 7.

Geschäftsstelle Qualitätssicherung Hessen, GQH, Eschborn.

Introduction: An independently managed, specialty obstetric unit in a small hospital setting resulted in measurable changes in quality of maternity care.

Material And Methods: We present obstetric data from a level I (basic care) hospital in Frankfurt, Germany. We compare data from the mandatory state register collected in 2013, when the obstetric unit was under single management with the gynaecology department, with data collected in 2016 after the establishment of independent obstetric unit and a specialised service. Read More

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December 2018

Association between Caffeine Consumption in Pregnancy and Low Birth Weight and Preterm Birth in the birth Cohort of Ribeirão Preto.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):749-756. Epub 2018 Dec 7.

Department of Pediatrics, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Objective:  To describe caffeine consumption during pregnancy and its association with low birth weight (LBW) and preterm birth in the birth cohort of Ribeirão Preto, state of São Paulo, Brazil, in 2010.

Methods:  Cohort study, with descriptive and analytical approach. Data included 7,607 women and their newborns in Ribeirão Preto, state of São Paulo, Brazil. Read More

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December 2018
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Outcome of pregnancy in women with psoriatic arthritis compared to healthy controls.

Clin Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Centre for Prognosis Studies in the Rheumatic Diseases, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Objectives: The mean age at onset of psoriatic arthritis (PsA) ranges between the 4th-6th decades of life. However, little is known about fertility and pregnancy outcome in PsA patients. The aim of this study was to examine whether fertility and pregnancy outcome of PsA patients are different from healthy controls and to evaluate PsA and psoriasis disease activity perception during pregnancy and the year postpartum. Read More

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December 2018

N-Acetylcysteine protects against intrauterine growth retardation-induced intestinal injury via restoring redox status and mitochondrial function in neonatal piglets.

Eur J Nutr 2018 Dec 10. Epub 2018 Dec 10.

College of Animal Science and Technology, Nanjing Agricultural University, No. 1, Weigang Road, Nanjing, 210095, Jiangsu, People's Republic of China.

Purpose: Intrauterine growth retardation (IUGR) is detrimental to the intestinal development of neonates, yet satisfactory treatment strategies remain limited. This study was, therefore, conducted using neonatal piglets as a model to investigate the potential of N-acetylcysteine (NAC) to alleviate intestinal damage caused by IUGR.

Methods: Seven normal birth weight (NBW) and fourteen IUGR neonatal male piglets were selected and then fed a basal milk diet (NBW-CON and IUGR-CON groups) or a basal milk diet supplemented with 1. Read More

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December 2018

Childhood vaccination in Kenya: socioeconomic determinants and disparities among the Somali ethnic community.

Int J Public Health 2018 Dec 10. Epub 2018 Dec 10.

Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.

Objectives: Kenya has a significant refugee population, including large numbers of Somali migrants. This study examines the vaccination status of Kenyan children and sociodemographic predictors of vaccination, including Somali ethnicity.

Methods: Using the 2014 Kenyan Demographic and Health Survey, we calculated the proportion of non-vaccinated, under-vaccinated, and fully vaccinated children, defining full vaccination as one dose Bacille Calmette-Guerin, three doses polio, three doses pentavalent, and one dose measles. Read More

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December 2018
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Management and pregnancy outcomes of women with GCK-MODY enrolled in the US Monogenic Diabetes Registry.

Acta Diabetol 2018 Dec 11. Epub 2018 Dec 11.

Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Kovler Diabetes Center, University of Chicago, 5841 South Maryland Ave., MC 1027, Chicago, IL, 60637, USA.

Aims: GCK-MODY is characterized by mild hyperglycemia. Treatment is not required outside of pregnancy. During pregnancy, insulin treatment is recommended if second trimester fetal ultrasound monitoring shows macrosomia, suggesting the fetus has not inherited the GCK gene. Read More

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December 2018

Family structure, birth order, and aggressive behaviors among school-aged boys with attention deficit hyperactivity disorder (ADHD).

Soc Psychiatry Psychiatr Epidemiol 2018 Dec 7. Epub 2018 Dec 7.

Institute of Public Health, National Yang-Ming University, 155 Li-Nong St., Sec. 2 Beitou, Taipei, Taiwan.

Purpose: To evaluate the associations between family structure, birth order, and aggressive behaviors among school-aged boys with attention deficit hyperactivity disorder (ADHD).

Methods: We conducted a matched case-control study. Data were retrieved from medical records at a psychiatry center in northern Taiwan. Read More

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December 2018

A Randomized, Controlled Trial of the Impact of the Couple CARE for Parents of Newborns Program on the Prevention of Intimate Partner Violence and Relationship Problems.

Prev Sci 2018 Dec 7. Epub 2018 Dec 7.

Centers for Disease Control and Prevention, Atlanta, GA, USA.

Effective, accessible prevention programs are needed for adults at heightened risk for intimate partner violence (IPV). This parallel group randomized controlled trial examines whether such couples receiving the American version of Couple CARE for Parents of Newborns (CCP; Halford et al. 2009) following the birth of a child, compared with controls, report fewer first occurrences of clinically significant IPV, less frequent physical and psychological IPV, and improved relationship functioning. Read More

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December 2018

Therapeutic abortion and ectopic pregnancy: alternative sources for fetal stem cell research and therapy in Iran as an Islamic country.

Cell Tissue Bank 2018 Dec 7. Epub 2018 Dec 7.

Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Regenerative medicine as a background of stem cell research and therapy has a long history. A wide variety of diseases including Parkinson's disease, heart diseases, multiple sclerosis, spinal cord injury, diabetes mellitus and etc. are candidate to be treated using different types of stem cells. Read More

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December 2018
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The Effects of Group Prenatal Care on Infant Birthweight and Maternal Well-Being: A Randomized Controlled Trial.

Mil Med 2018 Dec 7. Epub 2018 Dec 7.

John Muir Physician Network Clinical Research Center, 2700 Grant St., Suite 202, Concord, CA.

Introduction: Group prenatal care models have been in use in the USA for over 20 years and have shown benefits in reducing rates of preterm birth and low birth weight infants in high-risk civilian populations. Group prenatal care has been widely implemented at military treatment facilities, despite a lack of high-quality evidence for improved perinatal outcomes in this population.

Materials And Methods: In this randomized, controlled trial, 129 patients at a military treatment facility received either traditional one-on-one prenatal care or group prenatal care using the CenteringPregnancy model. Read More

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December 2018

A potential role for GSK3beta in glucose-driven intrauterine catch-up growth in maternal obesity.

Endocrinology 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatrics and Adolescent Medicine, University Hospital of Cologne, Cologne, Germany.

Obesity and an unhealthy nutrition are on the rise and affect also women in childbearing age and hence, during pregnancy. Despite normal or even high birth weight the offspring suffers from long term metabolic risks. We hypothesized that fetal growth is disturbed during different intrauterine phases. Read More

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December 2018

Childhood cognition and age-related change in standing balance performance from mid to later life: findings from a British birth cohort.

J Gerontol A Biol Sci Med Sci 2018 Dec 8. Epub 2018 Dec 8.

MRC Unit for Lifelong Health and Ageing at UCL, London, UK.

Background: Cognitive processing plays a crucial role in the integration of sensory input and motor output that facilitates balance. However, whether balance ability in adulthood is influenced by cognitive pathways established in childhood is unclear, especially as no study has examined if these relationships change with age. We aimed to investigate associations between childhood cognition and age-related change in standing balance between mid and later life. Read More

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December 2018

Increased risk of malaria during the first year of life in small-birth-weight-for-gestational age infants: a longitudinal study in Benin.

J Infect Dis 2018 Dec 7. Epub 2018 Dec 7.

MERIT, IRD, Université Paris 5, Sorbonne Paris Cité, Paris, France.

Background: According to the DOHaD paradigm, the foetal period is one of the most vulnerable periods that may have profound effects on health later in life. Few studies have assessed the effect of small-birth-weight-for-gestational age (SGA), a proxy for foetal growth impairment, on the risk of malaria during infancy in Africa.

Methods: We used data from a cohort of 398 mother-child pairs, followed from early pregnancy to age one in Benin. Read More

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December 2018

Effect of dietary protein intake on energy utilization and feed efficiency of lactating sows.

J Anim Sci 2018 Dec 7. Epub 2018 Dec 7.

Animal Science, Faculty of Science and Technology, Aarhus University, Tjele, Denmark.

The objective of the current study was to quantify loss of energy in feces, urine, heat and milk, to evaluate feed efficiency and to evaluate optimal ratio of dietary CP to energy for lactating sows fed increasing dietary CP. A total of 72 sows were included in the experiment from d 2 after parturition until weaning at d 28. Sows were allocated to six dietary treatments formulated to be isocaloric (9. Read More

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December 2018

Bayesian hierarchical model for comparison of different nonlinear function and genetic parameter estimates of meat quails.

Poult Sci 2018 Dec 7. Epub 2018 Dec 7.

Department of Animal Science, Faculty of Agronomy Eliseu Maciel, Federal University of Pelotas, PO Box 354, 96010-900 Pelotas, RS, Brazil.

This study aimed to compare different nonlinear functions to describe the growth curve of European quails and to estimate growth curve parameters, (co)variance components, and genetic and systematic effects that affected the curve using a hierarchical Bayesian model that allows joint estimation. Three different models were fitted in the first stage (Gompertz, Logístic, and von Bertalanffy). The analyzed data set had 45,965 records of 6,838 meat quails selected for higher body weight at 42 d of age for 15 successive generations, weighed at birth, 7, 14, 21, 28, 35, and 42 d of age. Read More

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December 2018

Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies.

Ann Intern Med 2018 Dec 11. Epub 2018 Dec 11.

National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina (C.R.W., D.P.S.).

Background: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or specific tumor subtype has rarely been evaluated.

Objective: To characterize breast cancer risk in relation to recent childbirth. Read More

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December 2018

Physiology Symposium: Postnatal Consequences of Heat Stress During Fetal Development.

J Anim Sci 2018 Dec 10. Epub 2018 Dec 10.

Iowa State University Department of Animal Science, Ames, IA, 50011.

Postnatal heat stress negatively impacts pig productivity and well-being as animals attempt to manage the resultant strain response. This is especially true when postnatal heat stress is combined with production stressors (e.g. Read More

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December 2018

[Anual Report Epidemiology of gonorrohea (CIE 10: A54)].

Authors:
Karen Cáceres

Rev Chilena Infectol 2018 Aug;35(4):403-412

Departamento de Epidemiología, División de Planificación Sanitaria, Ministerio de Salud de Chile, Chile.

Gonorrhea is produced by the bacterium Neisseria gonorrhoeae, which is capable of infecting different types of mucous membranes depending on sexual practices. It is located preferably in the man's urethra and in the woman's cervix, also in the rectum and pharynx. Its main form of transmission is through unprotected sex and, occasionally, through the birth canal in newborns. Read More

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The acute abdomen in pregnancy and postpartum of a teenager woman. Case report.

Rom J Morphol Embryol 2018 ;59(3):939-943

Department of Pediatric Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of General Surgery, University of Medicine and Pharmacy of Craiova, Romania;

The acute abdomen with its many clinical aspects is not a condition that eludes pregnancy; acute appendicitis being the most frequently incriminated, but when it comes to its complication - peritonitis and the pregnant is a teenager, the cases cited in the literature are quite rare. We present the case of a 15-year-old teenager pregnant within 24 weeks admitted from the emergency department with the diagnosis of acute abdomen and operated for generalized peritonitis due to a perforated appendicitis. The microscopic analysis of the specimen indicated the presence of ulceration and extensive and deep and necrosis of the appendicle wall, the residual structures being dissected by a predominantly polymorphonuclear leukocytes inflammatory infiltrate associated with eosinophilic fibrinous deposits. Read More

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January 2018

Placental findings in pregnancies complicated with IUGR - histopathological and immunohistochemical analysis.

Rom J Morphol Embryol 2018 ;59(3):715-720

Department of Anesthesiology and Intensive Care, University of Medicine and Pharmacy of Craiova, Romania; Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Romania;

Objective: Placental lesions and placental ischemia are typical elements of intrauterine growth restriction (IUGR). The aim of this study is to analyze histological and immunohistochemical (IHC) changes in the placentas of IUGR fetuses.

Materials And Methods: In this prospective study, 126 placentas from small for gestational age (SGA) pregnancies (newborns with birth weight <10th percentile) that formed the study group and 31 placentas from pregnancies without SGA representing control group, were included. Read More

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January 2018

Opening the Blood-Brain Barrier and Improving the Efficacy of Temozolomide Treatments of Glioblastoma Using Pulsed, Focused Ultrasound with a Microbubble Contrast Agent.

Biomed Res Int 2018 11;2018:6501508. Epub 2018 Nov 11.

Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: To explore the effects of pulsed, focused, and microbubble contrast agent-enhanced ultrasonography (mCEUS) on blood-brain barrier (BBB) permeability and the efficacy temozolomide for glioblastoma.

Methods: Wistar rats (n = 30) were divided into three groups (n = 10 per group) to determine optimal CUES conditions for achieving BBB permeability, as assessed by ultrastructure transmission electron microscopy (TEM) and western blot assays for the tight junction protein claudin-5. Optimized mCEUS effects on BBB permeability were subsequently confirmed with Evans blue staining (2 groups of 10 rats). Read More

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November 2018

Wound Dehiscence after Posterior Sagittal Anorectoplasty in Children with Anorectal Malformations.

Biomed Res Int 2018 11;2018:2930783. Epub 2018 Nov 11.

Department of Paediatric Surgery, Skåne University Hospital, Department of Clinical Sciences, Paediatrics, Lund University, Lund, Sweden.

Aim Of The Study: To assess the frequency of and identify contributing factors to wound dehiscence after posterior sagittal anorectoplasty (PSARP) in children born with anorectal malformations (ARM).

Methods: Ethical approval was obtained (DNR 2017/191). Charts of all children with anorectal malformations (ARM) reconstructed with PSARP, limited PSARP, or PSARVUP at a tertiary centre of paediatric surgery between 2001 and 2016 were reviewed. Read More

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November 2018

Reinforcing kangaroo mother care uptake in resource limited settings.

Matern Health Neonatol Perinatol 2018 4;4:26. Epub 2018 Dec 4.

Pacific Medical College and Hospital, Udaipur, 313 001 India.

Background: The national and global coverage of kangaroo mother care (KMC) remains low. Hence, adjuncts to KMC may be necessary, especially on day1 of life when neonatal mortality is high. It is important to provide warmth and reduce mortality in preterm low birth weight (LBW) infants in the community/hospital setting. Read More

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December 2018

A novel intragenic deletion in in a Japanese patient with Dandy-Walker malformation.

Hum Genome Var 2019 5;6. Epub 2018 Dec 5.

8Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, 187-8551 Japan.

Dandy-Walker malformation (DWM) is a rare congenital malformation defined by hypoplasia of the cerebellar vermis and cystic dilatation of the fourth ventricle. Oligophrenin-1 is mutated in X-linked intellectual disability with or without cerebellar hypoplasia. Here, we report a Japanese DWM patient carrying a novel intragenic 13. Read More

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December 2018

Links between patient safety and fear of childbirth-A meta-study of qualitative research.

Nurs Open 2019 Jan 16;6(1):18-29. Epub 2018 Jul 16.

Department of Nursing and Health Sciences, Faculty of Health and Social Sciences, Centre for Women's, Family and Child Health University of South-Eastern Norway Kongsberg Norway.

Aim: To conduct a meta-study of qualitative empirical research to explore the links between patient safety and fear of childbirth in the maternity care context. The review questions were: How are patient safety and fear of childbirth described? and What are the links between patient safety and fear of childbirth in the maternity care context?

Design: Meta-study.

Data Sources: The CINAHL, Cochrane, PubMed, Webb of Science, Proquest and Medline (Ovid) electronic databases were searched for articles published between June 2000-June 2016. Read More

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January 2019

Effect of Vitamin E in Prevention of Intraventricular Hemorrhage in Preterm Neonates.

Int J Prev Med 2018 5;9:97. Epub 2018 Nov 5.

Department of Pediatrics, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Germinal matrix-intraventricular hemorrhage (IVH) is the most common brain hemorrhage in preterm neonates. The importance of this hemorrhage lies in its severe complications. There is no definite treatment for IVH in neonates; therefore, the prevention of IVH should be considered. Read More

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November 2018

User-friendly extraction and multistage tandem mass spectrometry based analysis of lipid-linked oligosaccharides in microalgae.

Plant Methods 2018 5;14:107. Epub 2018 Dec 5.

1UNIROUEN, Laboratoire Glyco-MEV EA4358, Normandie Univ, 76000 Rouen, France.

Background: Protein -glycosylation is initiated within the endoplasmic reticulum through the synthesis of a lipid-linked oligosaccharides (LLO) precursor. This precursor is then transferred on neo-synthesized proteins through the action of the oligosaccharyltransferase giving birth to glycoproteins. The -linked glycans bore by the glycoproteins are then processed into oligomannosides prior to the exit of the glycoproteins from the endoplasmic reticulum and its entrance into the Golgi apparatus. Read More

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December 2018

Postnatal Growth Restriction Is Reduced If Birth Weight Is Used for Nutritional Calculations in ELBW Infants.

Int J Pediatr 2018 11;2018:2045370. Epub 2018 Nov 11.

University of Health Sciences, Farmington, CT, USA.

Since fluid and nutrition needs and delivery in ELBW infants are calculated based on their body weights, there could be a measurable difference in fluid, nutrition, and protein intake calculations based on birth weight (BW) or current weight of the infant, especially in the first two weeks of life. Theoretically, the use of current daily weight (CW) for calculations may result in decreased fluid, nutrition, and protein delivery as well as a cumulative protein deficit (cPD) over the first two weeks of life until the infant regains birth weight. However, there have been no clinical studies comparing the clinical and nutritional impact of these two strategies is unknown. Read More

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November 2018

Association of Fatty Acid Ethyl Esters in Meconium of Neonates with Growth Deficits at Birth: a Prospective, Single-Centre Cohort Study.

J Korean Med Sci 2018 Dec 15;33(50):e318. Epub 2018 Nov 15.

Department of Psychiatry, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: In this prospective cohort study, we investigated the association between fatty acid ethyl esters (FAEEs) in meconium as biomarkers of prenatal ethanol exposure and growth deficits, as birth outcomes, that constitute several of the key cardinal features of fetal alcohol syndrome.

Methods: A total of 157 meconium samples were collected from enrolled infants within 24 hours of birth, and nine FAEEs were quantified using liquid chromatography/tandem mass spectrometry. The relationships between cumulative concentrations of nine species of FAEEs in meconium and birth parameters of growth (age-sex-specific centiles of head circumference [HC], weight, and length) and respective and combined birth outcomes of growth deficits (HC ≤ 10th centile, weight ≤ 10th centile, and length ≤ 10th centile) were determined. Read More

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December 2018
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How to Read a Research Paper: An Exercise Using a Study on Continuation vs. Discontinuation of Antidepressants during Pregnancy.

Indian J Psychol Med 2018 Nov-Dec;40(6):600-601

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

The ability to critically read a research paper is a skill that all postgraduate students and academicians require because the findings of a study must be interpreted in the context of its strengths and limitations. This article summarizes a recent study on continuation vs. discontinuation of antidepressants during pregnancy; preterm birth and low-birth weight were the outcomes of interest. Read More

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December 2018

First-Time Fathers' Experience of Support from Midwives in Maternity Clinics: An Interview Study.

Nurs Res Pract 2018 8;2018:9618036. Epub 2018 Nov 8.

School of Health and Education, University of Skövde, Skövde, Sweden.

Background: Research shows that first-time fathers want to take part in preparation for birth and parenthood but they describe being excluded by health professionals.

Aim: The aim of this study was to illustrate first-time fathers' experiences of support from midwives in maternity clinics as a step in the validation of "The Father Perceived-Professional-Support" (The FaPPS) scale.

Methods: A qualitative content analysis with an inductive and deductive approach was used; seven first-time fathers were strategically selected and interviewed. Read More

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November 2018